Works (15)

Updated: December 22nd, 2023 05:00

2023 journal article

Characterizing Adeno-Associated Virus Capsids with Both Denaturing and Intact Analysis Methods

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 34(12), 2811–2821.

By: J. Ryan*, M. Kostelic*, C. Hsieh*, J. Powers n, C. Aspinwall*, J. Dodds*, J. Schiel, M. Marty*, E. Baker*

Source: Web Of Science
Added: December 18, 2023

2023 journal article

Using Multidimensional Separations to Distinguish Isomeric Amino Acid-Bile Acid Conjugates and Assess Their Presence and Perturbations in Model Systems

ANALYTICAL CHEMISTRY, 95(41), 15357–15366.

By: A. Stewart n, M. Foley n, M. Dougherty*, S. Mcgill*, A. Gulati*, E. Gentry*, L. Hagey*, P. Dorrestein* ...

TL;DR: This work analyzed 8 core bile acids synthetically conjugated with 22 proteinogenic and nonproteogenic amino acids totaling 176 MCBAs and created an in-house extended bile acid library that was applied to healthy mice dosed with antibiotics and humans having fecal microbiota transplantation (FMT) to assess the MCBA presence and changes in the gut before and after each perturbation. (via Semantic Scholar)
Source: Web Of Science
Added: October 30, 2023

2022 journal article

Characterization of compositional variability in petroleum substances

FUEL, 317.

By: A. Roman-Hubers*, A. Cordova*, A. Rohde*, W. Chiu*, T. McDonald*, F. Wright*, J. Dodds n, E. Baker n, I. Rusyn*

author keywords: UVCB; Registration; Variability; IMS-MS
Sources: Web Of Science, ORCID
Added: May 10, 2022

2022 article

Combining Isotopologue Workflows and Simultaneous Multidimensional Separations to Detect, Identify, and Validate Metabolites in Untargeted Analyses

Dodds, J. N., Wang, L., Patti, G. J., & Baker, E. S. (2022, January 28). ANALYTICAL CHEMISTRY, Vol. 1.

By: J. Dodds n, L. Wang*, G. Patti* & E. Baker n

MeSH headings : Chromatography, Liquid; Ion Mobility Spectrometry; Metabolomics / methods; Tandem Mass Spectrometry; Workflow
TL;DR: The analytical utility of incorporating ion mobility spectrometry (IMS) as an additional separation mechanism into standard LC-MS/MS isotopologue workflows is evaluated to highlight the enhanced separation space and increased annotation confidence afforded by IMS for metabolic characterization and provide a unique perspective for future developments in isotopically labeled MS experiments. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: March 14, 2022

2022 journal article

High-Resolution Demultiplexing (HRdm) Ion Mobility Spectrometry-Mass Spectrometry for Aspartic and Isoaspartic Acid Determination and Screening

ANALYTICAL CHEMISTRY, 94(16), 6191–6199.

By: K. Butler n, J. Dodds n, T. Flick*, I. Campuzano* & E. Baker n

MeSH headings : Chromatography, Liquid; Ion Mobility Spectrometry / methods; Isoaspartic Acid / analysis; Mass Spectrometry / methods; Peptides
TL;DR: The rapid high-throughput HRdm DTIMS-MS method was presented to present the first application of HRdm for isoAsp and Asp assessment and demonstrate screening capabilities for isomeric peptides in complex samples, resulting in a workflow highly suitable for biopharmaceutical research needs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: May 23, 2022

2022 journal article

Temporal chemical composition changes in water below a crude oil slick irradiated with natural sunlight

MARINE POLLUTION BULLETIN, 185.

By: A. Roman-Hubers*, C. Aeppli*, J. Dodds n, E. Baker n, K. McFarlin*, D. Letinski*, L. Zhao*, D. Mitchell* ...

author keywords: Oil; Photodegradation; Photooxidation; Petroleomics; Toxicity; Spill
MeSH headings : Petroleum; Sunlight; Water; Petroleum Pollution; Seawater
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID
Added: February 20, 2023

2022 journal article

Uncovering PFAS and Other Xenobiotics in the Dark Metabolome Using Ion Mobility Spectrometry, Mass Defect Analysis, and Machine Learning

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 56(12), 9133–9143.

By: M. Foster n, M. Rainey*, C. Watson*, J. Dodds n, K. Kirkwood n, F. Fernandez*, E. Baker n

author keywords: xenobiotics; per- and polyfluoroalkyl substances; ion mobility spectrometry; mass spectrometry; mass defect; machine learning; PFAS
MeSH headings : Fluorocarbons; Humans; Ion Mobility Spectrometry / methods; Machine Learning; Metabolome; Xenobiotics
TL;DR: A xenobiotic structural annotation workflow using ion mobility spectrometry coupled with MS (IMS-MS), mass defect filtering, and machine learning to uncover potential xenobiotics classes and species in large metabolomic feature lists is evaluated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: July 5, 2022

2021 review

From Pesticides to Per- and Polyfluoroalkyl Substances: An Evaluation of Recent Targeted and Untargeted Mass Spectrometry Methods for Xenobiotics

[Review of ]. ANALYTICAL CHEMISTRY, 93(1), 641–656.

By: J. Dodds n, N. Alexander n, K. Kirkwood n, M. Foster n, Z. Hopkins n, D. Knappe n, E. Baker n

MeSH headings : Fluorocarbons / analysis; Mass Spectrometry; Xenobiotics / analysis
Sources: Web Of Science, ORCID
Added: February 4, 2021

2021 journal article

Improving the Speed and Selectivity of Newborn Screening Using Ion Mobility Spectrometry-Mass Spectrometry

ANALYTICAL CHEMISTRY, 93(51), 17094–17102.

By: J. Dodds n & E. Baker n

MeSH headings : Biomarkers; High-Throughput Screening Assays; Humans; Infant, Newborn; Ion Mobility Spectrometry; Mass Spectrometry; Neonatal Screening
TL;DR: The utility of ion mobility spectrometry (IMS) to enhance the accuracy of MS assays for primary (tier 1) screening is explored and the results suggest that ∼400 IMS resolving power would be required to confidently assess most NBS biomarkers of interest in dried blood spots (DBSs) that currently require follow-up testing. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: February 7, 2022

2021 article

Utilizing ion mobility spectrometry-mass spectrometry for the characterization and detection of persistent organic pollutants and their metabolites

Aly, N. A., Dodds, J. N., Luo, Y.-S., Grimm, F. A., Foster, M. K., Rusyn, I., & Baker, E. S. (2021, October 20). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 10.

By: N. Aly*, J. Dodds n, Y. Luo*, F. Grimm*, M. Foster n, I. Rusyn*, E. Baker n

author keywords: Ion Mobility Spectrometry; Pesticides; Pharmaceuticals; PFAS
MeSH headings : Environmental Monitoring / methods; Humans; Ion Mobility Spectrometry / methods; Mass Spectrometry / methods; Persistent Organic Pollutants / chemistry; Persistent Organic Pollutants / metabolism; Pesticides / analysis; Pesticides / metabolism; Pharmaceutical Preparations / analysis; Pharmaceutical Preparations / metabolism; Polychlorinated Biphenyls / analysis; Polychlorinated Biphenyls / metabolism
TL;DR: This study characterized 64 compounds including parent per- and polyfluoroalkyl substances, pesticides, polychlorinated biphenyls, industrial chemicals, and pharmaceuticals and personal care products, in addition to their metabolites and/or degradants, using ion mobility spectrometry coupled with MS (IMS-MS) as a potential rapid screening technique. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: November 1, 2021

2020 journal article

Rapid Characterization of Emerging Per- and Polyfluoroalkyl Substances in Aqueous Film-Forming Foams Using Ion Mobility Spectrometry-Mass Spectrometry

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 54(23), 15024–15034.

MeSH headings : Fluorocarbons / analysis; Ion Mobility Spectrometry; Tandem Mass Spectrometry; Water; Water Pollutants, Chemical / analysis
TL;DR: This work demonstrates that LC-IMS-MS-enabled untargeted analysis of complex formulations, followed by feature identification using data-processing algorithms, can be used for rapid exposure characterization of known and putative PFAS during fire suppression-related contamination events. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: January 19, 2021

2020 journal article

Temporal and spatial analysis of per and polyfluoroalkyl substances in surface waters of Houston ship channel following a large-scale industrial fire incident

Environmental Pollution, 265(B), 115009.

By: N. Aly*, Y. Luo*, Y. Liu*, G. Casillas*, T. McDonald*, J. Kaihatu*, M. Jun*, N. Ellis ...

MeSH headings : Drinking Water / analysis; Fires; Fluorocarbons / analysis; Texas; Water Pollutants, Chemical / analysis
TL;DR: A major peak in the level of many PFAS is found in the days and weeks after the ITC incident and a gradual decline over several months with patterns consistent with the tide- and wave-associated water movements. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 31, 2020

2019 article

Challenges in Identifying the Dark Molecules of Life

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 12, Vol. 12, pp. 177–199.

By: M. Eugenia Monge*, J. Dodds n, E. Baker n, A. Edison* & F. Fernandez*

Contributors: M. Monge*, J. Dodds n, E. Baker n, A. Edison* & F. Fernaacutendez

author keywords: metabolomics; metabolite identification; chromatography; ion mobility; tandem mass spectrometry; nuclear magnetic resonance spectroscopy
MeSH headings : Animals; Chromatography, Liquid / methods; Humans; Ion Mobility Spectrometry / methods; Magnetic Resonance Spectroscopy / methods; Mass Spectrometry / methods; Metabolome; Metabolomics / methods
TL;DR: The state-of-the-art in metabolite identification with specific applications in metabolomics is critically discussed and how technologies such as mass spectrometry, ion mobility, chromatography, and nuclear magnetic resonance currently contribute to this challenging task. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: July 1, 2019

2019 journal article

Ion Mobility Spectrometry: Fundamental Concepts, Instrumentation, Applications, and the Road Ahead

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 30(11), 2185–2195.

By: J. Dodds n & E. Baker n

Contributors: J. Dodds n & E. Baker n

author keywords: Ion mobility spectrometry; IMS; Untargeted metabolomics; Mass spectrometry
TL;DR: This critical insight aims to clarify some common misconceptions for new users in the community pertaining to the fundamental concepts of the various IMS instrumental platforms, while addressing the strengths and shortcomings associated with each. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: November 25, 2019

2019 review

Ion mobility spectrometry and the omics: Distinguishing isomers, molecular classes and contaminant ions in complex samples

[Review of ]. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 116, 292–299.

By: K. Burnum-Johnson*, X. Zheng*, J. Dodds n, J. Ash n, D. Fourches n, C. Nicora*, J. Wendler*, T. Metz* ...

Contributors: K. Burnum-Johnson*, X. Zheng*, J. Dodds n, J. Ash n, D. Fourches n, C. Nicora*, J. Wendler*, T. Metz* ...

author keywords: Ion mobility spectrometry; Mass spectrometry; Omics; Proteomics; Lipidomics; Metabolomics; Glycomics; Exposomics
TL;DR: Ion mobility spectrometry has shown great utility in salvaging molecular information for low abundance molecules of interest when high concentration contaminant ions are present in the sample by reducing detector suppression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: July 1, 2019

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