Jamie Nosbisch

College of Sciences

Works (2)

Updated: July 5th, 2023 14:43

2022 journal article

A kinetic model of phospholipase C-?1 linking structure-based insights to dynamics of enzyme autoinhibition and activation


By: J. Nosbisch n, J. Bear* & J. Haugh n

MeSH headings : Animals; Carrier Proteins / metabolism; Isoenzymes / metabolism; Kinetics; Mammals / metabolism; Phospholipase C gamma / genetics; Phospholipase C gamma / metabolism; Phosphorylation; Protein-Tyrosine Kinases / metabolism; Type C Phospholipases / metabolism; src Homology Domains / genetics
TL;DR: A structure-based kinetic model of PLC-γ1 is introduced, considering interactions of its regulatory Src homology 2 (SH2) domains and perturbation of those dynamics upon phosphorylation of Tyr783, a hallmark of activation. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: June 20, 2022

2020 journal article

Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing


By: J. Nosbisch n, A. Rahman n, K. Mohan n, T. Elston*, J. Bear* & J. Haugh n

MeSH headings : Animals; Chemotaxis / physiology; Diglycerides / metabolism; Fibroblasts / metabolism; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Models, Theoretical; Myristoylated Alanine-Rich C Kinase Substrate / metabolism; Phosphatidic Acids / metabolism; Phosphatidic Acids / physiology; Phospholipase D / metabolism; Phosphorylation; Platelet-Derived Growth Factor / metabolism; Protein Kinase C / metabolism; Protein Kinase C / physiology; Signal Transduction / physiology; Type C Phospholipases / metabolism; Type C Phospholipases / physiology
TL;DR: In simulations of wound invasion, efficient collective migration is achieved with thresholds for chemotaxis matching those of polarization in the reaction-diffusion models, and increasing DAG kinase activity can enhance the robustness of DAG/active PKC polarization with respect to chemoattractant concentration while decreasing their whole-cell levels. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: May 26, 2020

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