Jamie Nosbisch
College of Sciences
Works (2)
Updated: July 5th, 2023 14:43
2022 journal article
A kinetic model of phospholipase C-?1 linking structure-based insights to dynamics of enzyme autoinhibition and activation
JOURNAL OF BIOLOGICAL CHEMISTRY, 298(5).
MeSH headings : Animals; Carrier Proteins / metabolism; Isoenzymes / metabolism; Kinetics; Mammals / metabolism; Phospholipase C gamma / genetics; Phospholipase C gamma / metabolism; Phosphorylation; Protein-Tyrosine Kinases / metabolism; Type C Phospholipases / metabolism; src Homology Domains / genetics
TL;DR:
A structure-based kinetic model of PLC-γ1 is introduced, considering interactions of its regulatory Src homology 2 (SH2) domains and perturbation of those dynamics upon phosphorylation of Tyr783, a hallmark of activation.
(via Semantic Scholar)
open access via www.ncbi.nlm.nih.gov (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022
2020 journal article
Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing
PLOS COMPUTATIONAL BIOLOGY, 16(4).
MeSH headings : Animals; Chemotaxis / physiology; Diglycerides / metabolism; Fibroblasts / metabolism; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Models, Theoretical; Myristoylated Alanine-Rich C Kinase Substrate / metabolism; Phosphatidic Acids / metabolism; Phosphatidic Acids / physiology; Phospholipase D / metabolism; Phosphorylation; Platelet-Derived Growth Factor / metabolism; Protein Kinase C / metabolism; Protein Kinase C / physiology; Signal Transduction / physiology; Type C Phospholipases / metabolism; Type C Phospholipases / physiology
TL;DR:
In simulations of wound invasion, efficient collective migration is achieved with thresholds for chemotaxis matching those of polarization in the reaction-diffusion models, and increasing DAG kinase activity can enhance the robustness of DAG/active PKC polarization with respect to chemoattractant concentration while decreasing their whole-cell levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020
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