Works (48)

Updated: March 6th, 2026 09:19

2026 article

It's a Gas: Bioconjugation With Vapor‐Phase Reagents

Ding, Y., Ohata, J., & Ball, Z. T. (2026, February 21). Chemistry - A European Journal.

By: Y. Ding*, J. Ohata n & Z. Ball*

topics (OpenAlex): Chemical Synthesis and Analysis; Click Chemistry and Applications; Biochemical and Structural Characterization
Source: NC State University Libraries
Added: March 4, 2026

2025 article

A histochemical approach to activity-based copper sensing reveals cuproplasia-dependent vulnerabilities in cancer

Messina, M. S., Torrente, L., Pezacki, A. T., Humpel, H. I., Li, E. L., Miller, S. G., … Chang, C. J. (2025, January 15). Proceedings of the National Academy of Sciences, Vol. 122.

By: M. Messina*, L. Torrente*, A. Pezacki*, H. Humpel*, E. Li*, S. Miller*, O. Verdejo-Torres*, T. Padilla-Benavides* ...

author keywords: activity- based sensing; histochemical copper probe; transition metal signaling; cancer metabolism; antioxidant regulation
MeSH headings : Copper / metabolism; Humans; Cell Line, Tumor; Neoplasms / metabolism; Neoplasms / pathology; Puromycin / pharmacology; Puromycin / analogs & derivatives; Homeostasis; NF-E2-Related Factor 2 / metabolism; Cell Proliferation
topics (OpenAlex): Molecular Sensors and Ion Detection; Trace Elements in Health; Drug Transport and Resistance Mechanisms
Sources: Web Of Science, NC State University Libraries
Added: February 17, 2025

2025 article

Catalysis in Chemical Modification of Proteins

Ishizawa, S., Fujimura, K., Oisaki, K., Sato, S., & Ohata, J. (2025, April 7). ChemCatChem, Vol. 4.

author keywords: Bioorganic chemistry; Protein modifications; Proteins
topics (OpenAlex): Chemical Synthesis and Analysis
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 28, 2025

2025 article

Catalytic Serine Labeling in Nonaqueous, Acidic Media

Ishizawa, S., Uzoewulu, C. P., Iwakura, Y., Koirala, A., Sato, S., & Ohata, J. (2025, January 22). Chemistry - A European Journal, Vol. 2.

By: S. Ishizawa n, C. Uzoewulu n, Y. Iwakura n, A. Koirala n, S. Sato* & J. Ohata n

MeSH headings : Catalysis; Serine / chemistry; Carboxylic Acids / chemistry; Acylation; Proteins / chemistry; Alcohols / chemistry; Solvents / chemistry; Hydrogen-Ion Concentration
topics (OpenAlex): Chemical Synthesis and Analysis; Click Chemistry and Applications; Peptidase Inhibition and Analysis
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6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 11, 2025

2025 article

InP-Based Quantum Dots as Photosensitizers in Photodynamic Antimicrobial Materials

Chen, L., Jiang, C., Scholle, F., Meo, A. E., Ohata, J., Gorman, C. B., & Ghiladi, R. A. (2025, January 16). ACS Applied Bio Materials, Vol. 1.

By: L. Chen n, C. Jiang*, F. Scholle n, A. Meo n, J. Ohata n, C. Gorman n, R. Ghiladi n

author keywords: indium phosphide; quantum dot; photodynamictherapy; photosensitizer; singlet oxygen
MeSH headings : Quantum Dots / chemistry; Photosensitizing Agents / pharmacology; Photosensitizing Agents / chemistry; Photosensitizing Agents / chemical synthesis; Indium / chemistry; Indium / pharmacology; Materials Testing; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / chemical synthesis; Photochemotherapy; Phosphines / chemistry; Phosphines / pharmacology; Particle Size; Microbial Sensitivity Tests; Biocompatible Materials / chemistry; Biocompatible Materials / pharmacology; Biocompatible Materials / chemical synthesis; Methicillin-Resistant Staphylococcus aureus / drug effects; Humans
topics (OpenAlex): Biosensors and Analytical Detection; Photodynamic Therapy Research Studies; Advanced Photocatalysis Techniques
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7. Affordable and Clean Energy (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 16, 2025

2025 article

Prebiotic Roles of Formaldehyde as an Activating Agent and a Building Block in Solid-State Peptide Modification

Thuan, J. C., Koirala, A., Pirez, J., & Ohata, J. (2025, September 18). ACS Bio & Med Chem Au, Vol. 9.

By: J. Thuan n, A. Koirala n, J. Pirez n & J. Ohata n

author keywords: prebiotic chemistry; chemical evolution; mechanochemistry; formaldehyde; diketopiperazine; dehydroalanine; peptide
topics (OpenAlex): Origins and Evolution of Life; Enzyme Structure and Function; Microbial Metabolic Engineering and Bioproduction
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 18, 2025

2025 article

Tryptophan Bioconjugation through Auxiliary Boron-Accelerated, Additive-Free Friedel–Crafts Alkylation

Uzoewulu, C. P., Joyner, E. C., Thuan, J. C., Rose, K., Colella, B. M., Nizam, Z. M., … Ohata, J. (2025, December 19). JACS Au, Vol. 12.

By: C. Uzoewulu n, E. Joyner n, J. Thuan n, K. Rose n, B. Colella n, Z. Nizam n, S. Ishizawa n, Y. Meguro*, M. Enomoto*, J. Ohata n

topics (OpenAlex): Organoboron and organosilicon chemistry; Click Chemistry and Applications; Cyclopropane Reaction Mechanisms
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: December 21, 2025

2024 article

Catalysis in Protein Bioconjugation

Ishizawa, S., Fujimura, K., Oisaki, K., Sato, S., & Ohata, J. (2024, December 26).

topics (OpenAlex): Monoclonal and Polyclonal Antibodies Research; Click Chemistry and Applications
Source: ORCID
Added: December 27, 2024

2024 article

Catalytic Serine Labeling in Nonaqueous, Acidic Media

Ishizawa, S., Uzoewulu, C., Iwakura, Y., Koirala, A., Sato, S., & Ohata, J. (2024, September 27).

By: S. Ishizawa n, C. Uzoewulu n, Y. Iwakura n, A. Koirala n, S. Sato* & J. Ohata n

topics (OpenAlex): Chemical Synthesis and Analysis
Source: ORCID
Added: October 1, 2024

2024 article

Contextual Analysis of Scientific Publications for Advancing Writing Skills (CASPArS): Self-Learning for Science Writing Using Top Scientists’ Literature

Ohata, J., Martin, J. D., & Ison, A. (2024, December 6). Journal of Chemical Education, Vol. 12.

By: J. Ohata n, J. Martin n & A. Ison n

author keywords: Audience: General Public; Pedagogy: Communication/Writing; Topic: Learning Theories
topics (OpenAlex): Educational Methods and Impacts
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4. Quality Education (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: December 7, 2024

2024 article

Contextual Analysis of Scientific Publications for Advancing writing Skills (CASPArS): Self-Learning for Science Writing Using Top Scientists’ Literature

Ohata, J., Martin, J. D., & Ison, A. (2024, May 27).

By: J. Ohata n, J. Martin n & A. Ison n

topics (OpenAlex): Innovative Teaching and Learning Methods; Education and Critical Thinking Development
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4. Quality Education (OpenAlex)
Source: ORCID
Added: June 1, 2024

2024 article

Fluoroalcohols for chemical modification of biomolecules

Nuruzzaman, M., Nizam, Z. M., & Ohata, J. (2024, August 1). Tetrahedron Chem.

By: M. Nuruzzaman n, Z. Nizam n & J. Ohata n

topics (OpenAlex): Click Chemistry and Applications; Chemical Synthesis and Analysis; Fluorine in Organic Chemistry
Source: ORCID
Added: August 8, 2024

2024 article

Friedel-Crafts Reactions for Biomolecular Chemistry

Ohata, J. (2024, March 12).

By: J. Ohata n

topics (OpenAlex): Chemical Synthesis and Analysis; Click Chemistry and Applications
Source: ORCID
Added: March 15, 2024

2024 article

Friedel–Crafts reactions for biomolecular chemistry

Ohata, J. (2024, January 1). Organic & Biomolecular Chemistry, Vol. 4.

By: J. Ohata n

MeSH headings : Alkylation; Acylation; Proteins / chemistry; Amino Acids / chemistry; Amino Acids / chemical synthesis; Carbohydrates / chemistry; Carbohydrates / chemical synthesis; Fatty Acids / chemistry; Lipids / chemistry; Nucleosides / chemistry; Nucleosides / chemical synthesis; Peptides / chemistry; Peptides / chemical synthesis
topics (OpenAlex): Chemical Synthesis and Analysis; Click Chemistry and Applications; Carbohydrate Chemistry and Synthesis
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 22, 2024

2024 article

Hexafluoroisopropanol as a Bioconjugation Medium of Ultrafast, Tryptophan-Selective Catalysis

Nuruzzaman, M., Colella, B. M., Uzoewulu, C. P., Meo, A. E., Gross, E. J., Ishizawa, S., … Ohata, J. (2024, February 29). Journal of the American Chemical Society, Vol. 2.

By: M. Nuruzzaman n, B. Colella n, C. Uzoewulu n, A. Meo n, E. Gross n, S. Ishizawa n, S. Sana*, H. Zhang* ...

MeSH headings : Tryptophan; Proteins / chemistry; Peptides; Catalysis; Hydrocarbons, Fluorinated; Propanols
topics (OpenAlex): Peptidase Inhibition and Analysis; Click Chemistry and Applications; Monoclonal and Polyclonal Antibodies Research
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Sources: Web Of Science, NC State University Libraries
Added: March 18, 2024

2024 article

Redox-neutral, metal-free tryptophan labeling of polypeptides in hexafluoroisopropanol (HFIP)

Nuruzzaman, M., Colella, B. M., Nizam, Z. M., Cho, I. J. H., Zagorski, J., & Ohata, J. (2024, January 1). RSC Chemical Biology, Vol. 8.

By: M. Nuruzzaman n, B. Colella n, Z. Nizam n, I. Cho n, J. Zagorski n & J. Ohata n

topics (OpenAlex): Chemical Synthesis and Analysis; Fluorine in Organic Chemistry; Click Chemistry and Applications
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 8, 2024

2023 article

Chemical labeling strategies using biomolecule-compatible, nonaqueous media

Ohata, J. (2023, January 1). [Data Management Plan]. DMPTool.]. California Digital Library.

By: J. Ohata n

topics (OpenAlex):
Source: ORCID
Added: September 28, 2023

2023 article

Iron-sensitive protein conjugates formed with a Wittig reaction precursor in ionic liquid

Nizam, Z. M., Stowe, A. M., Mckinney, J. K., & Ohata, J. (2023, January 1). Chemical Communications, Vol. 59, pp. 12160–12163.

By: Z. Nizam n, A. Stowe n, J. Mckinney n & J. Ohata n

topics (OpenAlex): RNA and protein synthesis mechanisms; Carbohydrate Chemistry and Synthesis; Glycosylation and Glycoproteins Research
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 25, 2023

2023 article

Iron-sensitive protein conjugates formed with a Wittig reaction precursor in ionic liquid

CHEMICAL COMMUNICATIONS, Vol. 9.

By: Z. Nizam, A. Stowe, J. Mckinney & J. Ohata

topics (OpenAlex):
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Sources: Web Of Science, NC State University Libraries
Added: October 10, 2023

2023 article

Small-Molecule CO2 Donors Accelerate Three-Component Peptide/Protein Bioconjugation with Alkylazides and Phosphines in Ionic Liquids

Ohata, J., & Colella, B. M. (2023, November 16). Synlett, Vol. 12.

By: J. Ohata n & B. Colella n

author keywords: multicomponent reaction; CO2 donor; peptide; protein; amine; azide; phosphine
topics (OpenAlex): Click Chemistry and Applications; Peptidase Inhibition and Analysis; Chemical Synthesis and Analysis
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 2, 2024

2022 article

A puromycin-dependent activity-based sensing probe for histochemical staining of hydrogen peroxide in cells and animal tissues

Hoshi, K., Messina, M. S., Ohata, J., Chung, C. Y.-S., & Chang, C. J. (2022, May 13). Nature Protocols, Vol. 5.

By: K. Hoshi*, M. Messina*, J. Ohata n, C. Chung* & C. Chang*

MeSH headings : Animals; Fluorescent Dyes / chemistry; Hydrogen Peroxide / analysis; Mice; Oxidation-Reduction; Signal Transduction; Staining and Labeling
topics (OpenAlex): Molecular Sensors and Ion Detection; Advanced biosensing and bioanalysis techniques; Analytical Chemistry and Sensors
TL;DR: An optimized two-step, one-pot protocol for synthesizing Peroxymycin-1, an activity-based histochemical probe for hydrogen peroxide detection in fixed cell and mouse tissue samples with improved yields over the originally reported procedure. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 15, 2022

2022 article

Correction to “An Ionic Liquid Medium Enables Development of a Phosphine-Mediated Amine–Azide Bioconjugation Method”

El-Shaffey, H. M., Gross, E. J., Hall, Y. D., & Ohata, J. (2022, May 14). Correction to “An Ionic Liquid Medium Enables Development of a Phosphine-Mediated Amine–Azide Bioconjugation Method.” Journal of the American Chemical Society, Vol. 5.

By: H. El-Shaffey, E. Gross, Y. Hall & J. Ohata*

topics (OpenAlex): Click Chemistry and Applications; Chemical Synthesis and Analysis; Innovative Microfluidic and Catalytic Techniques Innovation
Source: ORCID
Added: May 15, 2022

2022 article

Correction: Site-specific DNA functionalization through the tetrazene-forming reaction in ionic liquids

Ishizawa, S., Tumurkhuu, M., Gross, E. J., & Ohata, J. (2022, January 1). Chemical Science, Vol. 6.

By: S. Ishizawa n, M. Tumurkhuu n, E. Gross n & J. Ohata n

topics (OpenAlex): Click Chemistry and Applications; Innovative Microfluidic and Catalytic Techniques Innovation; Molecular Junctions and Nanostructures
TL;DR: The non-traditional medium-promoted labeling strategy described here provides an alternative design paradigm for future development of chemical tools for applications involving DNA functionalization. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022

2022 article

Phosphine-Mediated Three-Component Bioconjugation of Amino- and Azidosaccharides in Ionic Liquids

Ohata, J., Hall, Y., Uzoewulu, C., Nizam, Z., Ishizawa, S., & El-Shaffey, H. (2022, April 17).

topics (OpenAlex): Click Chemistry and Applications; Cancer Research and Treatments
Source: ORCID
Added: April 20, 2022

2022 article

Phosphine-mediated three-component bioconjugation of amino- and azidosaccharides in ionic liquids

Hall, Y. D., Uzoewulu, C. P., Nizam, Z. M., Ishizawa, S., El-Shaffey, H. M., & Ohata, J. (2022, January 1). Chemical Communications, Vol. 8.

By: Y. Hall n, C. Uzoewulu n, Z. Nizam n, S. Ishizawa n, H. El-Shaffey n & J. Ohata n

MeSH headings : Carbohydrates; Ionic Liquids / chemistry; Phosphines
topics (OpenAlex): Carbohydrate Chemistry and Synthesis; Click Chemistry and Applications; Glycosylation and Glycoproteins Research
TL;DR: This report has developed a bioconjugation strategy for labeling of carbohydrate derivatives through a phosphine-mediated three-component coupling reaction in an ionic liquid medium. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 2, 2022

2022 article

Site-specific DNA functionalization through the tetrazene-forming reaction in ionic liquids

Ishizawa, S., Tumurkhuu, M., Gross, E. J., & Ohata, J. (2022, January 1). Chemical Science, Vol. 1.

By: S. Ishizawa n, M. Tumurkhuu n, E. Gross n & J. Ohata n

topics (OpenAlex): Click Chemistry and Applications; Advanced biosensing and bioanalysis techniques; Chemical Synthesis and Analysis
TL;DR: The non-traditional medium-promoted labeling strategy described here provides an alternative design paradigm for future development of chemical tools for applications involving DNA functionalization. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 26, 2022

2022 article

Translation of a Phosphine- and Azide-Based Reaction to Chemical Modification of Biomolecules in Ionic Liquid

Ohata, J., & Uzoewulu, C. P. (2022, July 24). Synlett, Vol. 7.

By: J. Ohata* & C. Uzoewulu*

author keywords: bioconjugation; ionic liquid; amine; azide; phosphine; phosphazide; iminophosphorane
topics (OpenAlex): Click Chemistry and Applications; Chemical Synthesis and Analysis; Carbohydrate Chemistry and Synthesis
TL;DR: This Synpact article describes the pursuit of using an ionic liquid as a nonaqueous reaction medium to conduct phosphine- and azide-based bioconjugation reactions. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: July 25, 2022

2022 article

Translation of a phosphine- and azide-based reaction to chemical modification of biomolecules in ionic liquid

Uzoewulu, C., & Ohata, J. (2022, July 10).

By: C. Uzoewulu n & J. Ohata n

topics (OpenAlex): Click Chemistry and Applications; Biochemical and Molecular Research; Chemical Synthesis and Analysis
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UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: July 11, 2022

2021 article

An Ionic Liquid Medium Enables Development of a Phosphine-Mediated Amine–Azide Bioconjugation Method

El-Shaffey, H. M., Gross, E. J., Hall, Y. D., & Ohata, J. (2021, August 13). Journal of the American Chemical Society, Vol. 8.

By: H. El-Shaffey n, E. Gross n, Y. Hall n & J. Ohata n

topics (OpenAlex): Click Chemistry and Applications; Chemical Synthesis and Analysis; Innovative Microfluidic and Catalytic Techniques Innovation
TL;DR: It is demonstrated that an aprotic ionic liquid serves as a novel reaction solvent for protein bioconjugation without noticeable loss of the biomolecule functions. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 14, 2021

2021 article

Linear Hydrocarbon Chain Growth from a Molecular Diruthenium Carbide Platform

Ohata, J., Teramoto, A., Fujita, H., Takemoto, S., & Matsuzaka, H. (2021, September 15). Journal of the American Chemical Society, Vol. 9.

By: J. Ohata*, A. Teramoto*, H. Fujita*, S. Takemoto* & H. Matsuzaka*

topics (OpenAlex): Organometallic Complex Synthesis and Catalysis; Catalysts for Methane Reforming; Catalysis for Biomass Conversion
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 16, 2021

2021 article

Site-Specific DNA Functionalization through the Tetrazene-Forming Reaction in Ionic Liquids

Ishizawa, S., Tumurkhuu, M., Gross, E., & Ohata, J. (2021, September 13). (Vol. 9). Vol. 9.

topics (OpenAlex): Click Chemistry and Applications; Advanced biosensing and bioanalysis techniques; Chemical Synthesis and Analysis
Source: ORCID
Added: September 14, 2021

2021 article

Site-Specific DNA Functionalization through the Tetrazene-Forming Reaction in Ionic Liquids

Ishizawa, S., Tumurkhuu, M., Gross, E., & Ohata, J. (2021, September 13). (Vol. 9). Vol. 9.

topics (OpenAlex): Click Chemistry and Applications; Advanced biosensing and bioanalysis techniques; Chemical Synthesis and Analysis
Source: ORCID
Added: February 2, 2022

2020 article

An Activity-Based Methionine Bioconjugation Approach To Developing Proximity-Activated Imaging Reporters

Ohata, J., Krishnamoorthy, L., Gonzalez, M. A., Xiao, T., Iovan, D. A., Toste, F. D., … Chang, C. J. (2020, January 7). ACS Central Science, Vol. 6, pp. 32–40.

By: J. Ohata*, L. Krishnamoorthy*, M. Gonzalez*, T. Xiao*, D. Iovan*, F. Toste*, E. Miller*, C. Chang*

topics (OpenAlex): bioluminescence and chemiluminescence research; Click Chemistry and Applications; Molecular Sensors and Ion Detection
TL;DR: Application of PAIR to activity-based CaM detection provides a method for imaging integrated calcium activity in both in vitro cell and in vivo zebrafish models and can be potentially generalized to target a broader range of analytes by pairing appropriate activity- based protein probes with protein detection reagents in a proximity-driven manner. (via Semantic Scholar)
Source: ORCID
Added: December 16, 2020

2019 article

Activity-Based Sensing Methods for Monitoring the Reactive Carbon Species Carbon Monoxide and Formaldehyde in Living Systems

Ohata, J., Bruemmer, K. J., & Chang, C. J. (2019, September 5). Accounts of Chemical Research.

By: J. Ohata*, K. Bruemmer* & C. Chang*

MeSH headings : Animals; Carbon Monoxide / metabolism; Formaldehyde / metabolism; Humans; Molecular Probe Techniques
topics (OpenAlex): Heme Oxygenase-1 and Carbon Monoxide; Sulfur Compounds in Biology; Neuroscience of respiration and sleep
TL;DR: This Account summarizes work from the laboratory on the development of new chemical tools to monitor two important one-carbon RCS, CO and FA, through activity-based sensing (ABS), where the unique chemical reactivities of these small and transient analytes are leveraged, rather than lock-and-key binding considerations, for selective detection. (via Semantic Scholar)
Source: ORCID
Added: December 16, 2020

2019 article

An Activity-Based Methionine Bioconjugation Approach to Developing Proximity-Activated Imaging Reporters

Ohata, J., Krishnamoorthy, L., Gonzalez, M., Xiao, T., Iovan, D., Toste, F. D., … Chang, C. (2019, October 16).

By: J. Ohata*, L. Krishnamoorthy*, M. Gonzalez*, T. Xiao*, D. Iovan*, F. Toste*, E. Miller*, C. Chang*

topics (OpenAlex): Click Chemistry and Applications; bioluminescence and chemiluminescence research; Biotin and Related Studies
Source: ORCID
Added: October 22, 2021

2019 article

Rapid nickel(ii)-promoted cysteine S-arylation with arylboronic acids

Hanaya, K., Ohata, J., Miller, M. K., Mangubat-Medina, A. E., Swierczynski, M. J., Yang, D. C., … Ball, Z. T. (2019, January 1). Chemical Communications.

topics (OpenAlex): Click Chemistry and Applications; Sulfur-Based Synthesis Techniques; Chemical Synthesis and Analysis
TL;DR: This work demonstrates an operationally-simple cysteine arylation reaction 2-nitro-substituted arylboronic acids, promoted by a simple nickel(ii) salt, which exhibits strikingly fast reaction rates under physiological conditions in purely aqueous media with excellent selectivity toward Cysteine residues. (via Semantic Scholar)
Source: ORCID
Added: December 16, 2020

2018 article

A Naturally Encoded Dipeptide Handle for Bioorthogonal Chan–Lam Coupling

Ohata, J., Zeng, Y., Segatori, L., & Ball, Z. T. (2018, February 8). Angewandte Chemie International Edition, Vol. 57, pp. 4015–4019.

By: J. Ohata*, Y. Zeng*, L. Segatori* & Z. Ball*

author keywords: bioinorganic chemistry; copper; protein modifications; pyroglutamate; transition metals
topics (OpenAlex): Click Chemistry and Applications; Chemical Synthesis and Analysis; Biochemical and Structural Characterization
TL;DR: It is reported that pyroglutamate amide N-H bonds exhibit bioorthogonal copper-catalyzed Chan-Lam coupling at pyrogLutamate-histidine dipeptide sequences, allowing specific bioconjugation at a minimalist dipePTide tag. (via Semantic Scholar)
Source: ORCID
Added: December 16, 2020

2018 article

A Three‐Component Organometallic Tyrosine Bioconjugation

Ohata, J., Miller, M. K., Mountain, C. M., Vohidov, F., & Ball, Z. T. (2018, January 22). Angewandte Chemie International Edition, Vol. 57, pp. 2827–2830.

By: J. Ohata*, M. Miller*, C. Mountain*, F. Vohidov* & Z. Ball*

author keywords: arenes; bioinorganic chemistry; protein modifications; rhodium; transition metals
MeSH headings : Animals; Boronic Acids / chemical synthesis; Boronic Acids / chemistry; Catalysis; Cattle; Cell Line; Fluorescent Dyes / chemical synthesis; Fluorescent Dyes / chemistry; Humans; Models, Molecular; Oxidation-Reduction; Peptides / chemical synthesis; Peptides / chemistry; Proteins / chemical synthesis; Proteins / chemistry; Rhodium / chemistry; Salts / chemistry; Tyrosine / chemical synthesis; Tyrosine / chemistry
topics (OpenAlex): Click Chemistry and Applications; Peptidase Inhibition and Analysis; Chemical Synthesis and Analysis
TL;DR: An organometallic bioconjugation, employing rhodium(III) salts, to link boronic acids with tyrosine residues by an arene complex is described, allowing incorporation of useful functionalities, such as affinity handles or fluorophores. (via Semantic Scholar)
Source: ORCID
Added: December 16, 2020

2018 article

Metallvermittelte Funktionalisierung natürlicher Peptide und Proteine: Biokonjugation mit Übergangsmetallen

Ohata, J., Martin, S. C., & Ball, Z. T. (2018, September 25). Angewandte Chemie, Vol. 131, pp. 6238–6264.

By: J. Ohata*, S. Martin* & Z. Ball*

topics (OpenAlex): Chemical Synthesis and Analysis; Click Chemistry and Applications; Peptidase Inhibition and Analysis
Source: ORCID
Added: December 16, 2020

2018 article

Metal‐Mediated Functionalization of Natural Peptides and Proteins: Panning for Bioconjugation Gold

Ohata, J., Martin, S. C., & Ball, Z. T. (2018, September 25). Angewandte Chemie International Edition, Vol. 58, pp. 6176–6199.

By: J. Ohata*, S. Martin* & Z. Ball*

author keywords: bioinorganic chemistry; metalation; peptides; protein modification; transition metals
MeSH headings : Alkylation; Amino Acids / chemistry; Catalysis; Coordination Complexes / chemistry; Gold / chemistry; Metals / chemistry; Oxidation-Reduction; Peptides / chemistry; Peptides / metabolism; Proteins / chemistry; Proteins / metabolism
topics (OpenAlex): Click Chemistry and Applications; Chemical Synthesis and Analysis; Biochemical and Structural Characterization
TL;DR: Metal-based methods as well as their reactivity and selectivity for the functionalization of natural proteins and peptides for bioconjugation are examined. (via Semantic Scholar)
Source: ORCID
Added: December 16, 2020

2018 article

Rhodium at the chemistry–biology interface

Ohata, J., & Ball, Z. T. (2018, January 1). Dalton Transactions.

By: J. Ohata* & Z. Ball*

MeSH headings : Animals; Catalysis; Chemistry, Pharmaceutical; DNA / drug effects; Humans; Molecular Structure; Organometallic Compounds / chemical synthesis; Organometallic Compounds / chemistry; Organometallic Compounds / pharmacology; Proteins / antagonists & inhibitors; Proteins / metabolism; Rhodium / chemistry; Rhodium / pharmacology; Structure-Activity Relationship
topics (OpenAlex): Chemical Reactions and Isotopes; Amino Acid Enzymes and Metabolism; Pharmacological Effects and Toxicity Studies
TL;DR: A brief review of recent advances in the use of rhodium complexes in biological contexts, including medicinal chemistry, protein science, and chemical biology, highlights both structure- and reactivity-driven approaches to biological probes and discusses how coordination environment affects molecular properties in a biological environment. (via Semantic Scholar)
Source: ORCID
Added: December 16, 2020

2017 article

A Hexa-rhodium Metallopeptide Catalyst for Site-Specific Functionalization of Natural Antibodies

Ohata, J., & Ball, Z. T. (2017, August 16). Journal of the American Chemical Society, Vol. 139, pp. 12617–12622.

By: J. Ohata* & Z. Ball*

MeSH headings : Antibodies / chemistry; Catalysis; Humans; Immunoconjugates / chemistry; Metalloproteins / chemistry; Peptides / chemistry; Rhodium / chemistry; Spectrometry, Fluorescence; Tandem Mass Spectrometry
topics (OpenAlex): Monoclonal and Polyclonal Antibodies Research; Chemical Synthesis and Analysis; Click Chemistry and Applications
TL;DR: It is demonstrated that cooperative activity of a multimetallic metallopeptide enables efficient site-specific antibody functionalization, based on molecular recognition of the constant Fc region, which opens a new opportunity for quick and easy production of well-defined antibody conjugates from a variety of antibody sequence and species of origin. (via Semantic Scholar)
Source: ORCID
Added: December 16, 2020

2017 article

Ascorbate as a pro-oxidant: mild N-terminal modification with vinylboronic acids

Ohata, J., & Ball, Z. T. (2017, January 1). Chemical Communications, Vol. 53, pp. 1622–1625.

By: J. Ohata* & Z. Ball*

topics (OpenAlex): Click Chemistry and Applications; Peptidase Inhibition and Analysis; Chemical Synthesis and Analysis
TL;DR: This mild and selective aqueous reactivity enables selective single-modification of the B chain of human insulin with vinylboronate reagents. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: December 16, 2020

2016 article

Histidine-Directed Arylation/Alkenylation of Backbone N–H Bonds Mediated by Copper(II)

Ohata, J., Minus, M. B., Abernathy, M. E., & Ball, Z. T. (2016, June 2). Journal of the American Chemical Society, Vol. 138, pp. 7472–7475.

MeSH headings : Alkenes / chemistry; Boronic Acids / chemistry; Catalysis; Copper / chemistry; Histidine / chemistry; Hydrocarbons, Aromatic / chemistry; Hydrogen Bonding; Models, Molecular; Nitrogen / chemistry; Oxidation-Reduction; Thyrotropin-Releasing Hormone / chemistry
topics (OpenAlex): Click Chemistry and Applications; Chemical Synthesis and Analysis
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: December 16, 2020

2015 article

Convenient analysis of protein modification by chemical blotting with fluorogenic “click” reagents

Ohata, J., Vohidov, F., & Ball, Z. T. (2015, January 1). Molecular BioSystems, Vol. 11, pp. 2846–2849.

By: J. Ohata*, F. Vohidov* & Z. Ball*

MeSH headings : Alkynes / chemistry; Animals; Azides / chemistry; Cattle; Click Chemistry / methods; Fluorescent Dyes / chemistry; Fluorescent Dyes / metabolism; Peptides / chemistry; Peptides / metabolism; Protein Processing, Post-Translational; Serum Albumin, Bovine / metabolism
topics (OpenAlex): Click Chemistry and Applications; Monoclonal and Polyclonal Antibodies Research; Advanced Biosensing Techniques and Applications
TL;DR: Direct visualization of bioorthogonal alkyne or azide handles using fluorogenic azide-alkyne cycloaddition conducted on the surface of a blot membrane is conducted, and sensitivity similar to current commercially available fluorescence imaging methods is possible. (via Semantic Scholar)
Source: ORCID
Added: December 16, 2020

2015 article

Luminogenic iridium azide complexes

Ohata, J., Vohidov, F., Aliyan, A., Huang, K., Martí, A. A., & Ball, Z. T. (2015, January 1). Chemical Communications, Vol. 51, pp. 15192–15195.

By: J. Ohata*, F. Vohidov*, A. Aliyan*, K. Huang*, A. Martí* & Z. Ball*

MeSH headings : Azides / chemical synthesis; Azides / chemistry; Cell Line, Tumor; Coordination Complexes / chemical synthesis; Coordination Complexes / chemistry; Fluorescent Dyes / chemical synthesis; Fluorescent Dyes / chemistry; Humans; Iridium / chemistry; Phenanthrolines / chemical synthesis; Triazoles / chemistry
topics (OpenAlex): Click Chemistry and Applications; Advanced biosensing and bioanalysis techniques; bioluminescence and chemiluminescence research
TL;DR: The synthesis and characterization of luminogenic, bioorthogonal iridium probes is described, and a simple, modular synthesis via 5-azidophenanthroline allows structural variation and allows optimization of cell labeling. (via Semantic Scholar)
Source: ORCID
Added: December 16, 2020

2015 article

Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors

Vohidov, F., Knudsen, S. E., Leonard, P. G., Ohata, J., Wheadon, M. J., Popp, B. V., … Ball, Z. T. (2015, January 1). Chemical Science, Vol. 6, pp. 4778–4783.

topics (OpenAlex): Ferrocene Chemistry and Applications; Metal complexes synthesis and properties; Chemical Synthesis and Analysis
TL;DR: Specific, designed histidine–rhodium interactions allow a metallopeptide to bind Lyn kinase with nanomolar affinity and to activate kinase activity. (via Semantic Scholar)
Source: ORCID
Added: December 16, 2020

2014 article

A Diruthenium μ-Carbido Complex That Shows Singlet-Carbene-like Reactivity

Takemoto, S., Ohata, J., Umetani, K., Yamaguchi, M., & Matsuzaka, H. (2014, November 3). Journal of the American Chemical Society, Vol. 136, pp. 15889–15892.

By: S. Takemoto*, J. Ohata*, K. Umetani*, M. Yamaguchi* & H. Matsuzaka*

topics (OpenAlex): N-Heterocyclic Carbenes in Organic and Inorganic Chemistry; Catalytic Cross-Coupling Reactions; Organometallic Complex Synthesis and Catalysis
Source: ORCID
Added: December 16, 2020

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