@article{whelchel_palerme_tou_ward_2023, title={Retrospective evaluation of the etiology and clinical characteristics of peripheral edema in dogs}, ISSN={["1939-1676"]}, DOI={10.1111/jvim.16815}, abstractNote={AbstractBackgroundThe prevalence and clinical characteristics of different etiologies of peripheral edema in dogs are unknown.Hypothesis/ObjectivesTo determine the prevalence of different etiologies of peripheral edema, describe clinical characteristics that vary among etiologies, and report survival times.AnimalsFive hundred twenty‐seven dogs with peripheral edema.MethodsRetrospective medical record review. Differences in clinical variables among etiology groups were assessed by Kruskal‐Wallis testing with post hoc pairwise Dunn's testing and Chi‐square testing with Monte Carlo simulation.ResultsThe most common etiologies of peripheral edema in dogs were vasculitis (n = 193, 37%), lymphatic/venous obstruction (LVO; 114, 22%), and hypoalbuminemia (94, 18%). Right‐sided congestive heart failure (R‐CHF) was uncommon (25, 5%). Edema was localized in 377 (72%) dogs and generalized in 142 (27%) dogs, and hypoalbuminemia was more likely to cause generalized edema compared to LVO or vasculitis (P < .0001). Concurrent abdominal effusion (155, 29%) was more common than pleural (77, 15%) or pericardial (12, 2%) effusion. Abdominal and pleural effusion occurred more commonly in dogs with hypoalbuminemia or R‐CHF compared to LVO or vasculitis (P < .0001).Conclusions and Clinical ImportanceDistribution of edema, concurrent cavitary effusions, and clinicopathological data can help predict the underlying etiology of peripheral edema in dogs.}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Whelchel, Bradley D. and Palerme, Jean-Sebastien and Tou, Sandy P. and Ward, Jessica L.}, year={2023}, month={Jul} }
 @article{ames_vaden_atkins_palerme_langston_grauer_shropshire_bove_webb_2022, title={Prevalence of aldosterone breakthrough in dogs receiving renin-angiotensin system inhibitors for proteinuric chronic kidney disease}, ISSN={["1939-1676"]}, DOI={10.1111/jvim.16573}, abstractNote={AbstractBackgroundThe influence of aldosterone breakthrough (ABT) on proteinuria reduction during renin‐angiotensin system (RAS) inhibition for spontaneous proteinuric chronic kidney disease (CKDP) has not been determined in dogs.ObjectivesDetermine whether ABT occurs in dogs with CKDP and if it is associated with decreased efficacy in proteinuria reduction during RAS inhibitor treatment.AnimalsFifty‐six client‐owned dogs with CKDP and 31 healthy client‐owned dogs.MethodsProspective, multicenter, open‐label clinical trial. Dogs were treated with an angiotensin‐converting enzyme inhibitor or angiotensin receptor blocker alone or in combination at the attending clinician's discretion and evaluated at 5 time points over 6 months. Healthy dogs were used to determine the urine aldosterone‐to‐creatinine ratio cutoff that defined ABT. The relationship of ABT (present at ≥50% of visits) and proteinuria outcome (≥50% reduction in urine protein‐to‐creatinine ratio from baseline at ≥50% of subsequent visits) was evaluated. Mixed effects logistic regression was used to evaluate the relationship between clinical variables and outcomes (either successful proteinuria reduction or ABT).ResultsThirty‐six percent (20/56) of dogs had successful proteinuria reduction. Between 34% and 59% of dogs had ABT, depending on the definition used. Aldosterone breakthrough was not associated with proteinuria outcome. Longer duration in the study was associated with greater likelihood of successful proteinuria reduction (P = .002; odds ratio, 1.6; 95% confidence interval [CI], 1.2‐2.2).Conclusions and Clinical ImportanceAldosterone breakthrough was common in dogs receiving RAS inhibitors for CKDp but was not associated with proteinuria outcome.}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Ames, Marisa K. and Vaden, Shelly L. and Atkins, Clarke E. and Palerme, Jean-Sebastien and Langston, Catherine E. and Grauer, Gregory F. and Shropshire, Sarah and Bove, Christina and Webb, Tracy}, year={2022}, month={Nov} }
 @article{palerme_pan_parsons_kathariou_ward_jacob_2016, title={Isolation and characterization of atypical Listeria monocytogenes associated with a canine urinary tract infection}, volume={28}, ISSN={1040-6387 1943-4936}, url={http://dx.doi.org/10.1177/1040638716661381}, DOI={10.1177/1040638716661381}, abstractNote={Listeria monocytogenes, a well-described cause of encephalitis and abortion in ruminants and of food-borne illness in humans, is rarely associated with disease in companion animals. A case of urinary tract infection associated with an atypical, weakly hemolytic L. monocytogenes strain is described in a diabetic dog. The serotype of the L. monocytogenes isolate was determined to be 1/2a (3a), with the multilocus genotyping pattern 2.72_1/2a. A nucleotide substitution (Gly145Asp) was detected at residue 145 in the promoter prfA region. This residue is within the critical helix-turn-helix motif of PrfA. The source of the L. monocytogenes strain remains unknown, and the dog recovered after a 4-week course of cephalexin (30 mg/kg orally twice daily).}, number={5}, journal={Journal of Veterinary Diagnostic Investigation}, publisher={SAGE Publications}, author={Palerme, Jean-Sébastien and Pan, Po Ching and Parsons, Cameron T. and Kathariou, Sophia and Ward, Todd J. and Jacob, Megan E.}, year={2016}, month={Aug}, pages={604–607} }
 @article{meichner_palerme_neel_2014, title={Pathology in Practice Diagnosis and case summary: LGL lymphoma in a cat}, volume={244}, ISSN={["1943-569X"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84891698834&partnerID=MN8TOARS}, DOI={10.2460/javma.244.2.167}, abstractNote={A 9-year-old 4.59-kg (10.1-lb) spayed female domestic longhair cat was reevaluated 6 weeks after suspected cholangitis and subsequent sepsis were diagnosed.Although bacteriologic cultures of bile samples were not performed at that time, results of bacteriologic cultures of blood samples were positive for Escherichia coli that was resistant to most commonly used antimicrobials.Following discharge from the hospital, the cat' s condition initially improved with supportive treatment consisting of nutritional support via an esophageal feeding tube as well as SC administration of meropenem a and oral application of ondansetron hydrochloride b and lactulose.c These treatments were ongoing at the time of reevaluation.Within the days before the reevaluation, the cat was lethargic, with a waxing and waning appetite, polydipsia, and a 1-day episode of hematuria and pollakiuria.The cat was kept indoors}, number={2}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Meichner, Kristina and Palerme, Jean-Sebastien and Neel, Jennifer Anne}, year={2014}, month={Jan}, pages={167–169} }
 @article{palerme_brown_marks_birkenheuer_2013, title={Splenosystemic Shunts in Cats: A Retrospective of 33 Cases (2004-2011)}, volume={27}, ISSN={["1939-1676"]}, DOI={10.1111/jvim.12188}, abstractNote={BackgroundPortosystemic shunts are uncommonly reported in cats. The majority of reports describe congenital shunts in young cats originating from the left gastric vein. Although they are only rarely reported, acquired portosystemic shunts in cats appear to be more variable in their anatomic location.Hypothesis/ObjectiveTo describe the signalment and disease conditions found in cats with splenosystemic shunts.AnimalsThirty‐three client‐owned cats with documented splenosystemic shunts.Materials and MethodsRetrospective study. All cats with vascular communications between the splenic and left renal veins or the splenic vein and caudal vena cava diagnosed ultrasonographically between 2004 and 2011 were included. Collected data included age, breed, sex, presenting complaints, clinicopathologic data, as well as clinical diagnosis when available.ResultsSplenosystemic shunts were identified in 1.3% of the cats that had an abdominal ultrasound performed during the study period. Older, spayed female cats were found to be significantly overrepresented when compared with the total population of cats having undergone ultrasound over the same time period. A large proportion of cats (42%) had a hepatopathy with the potential for associated portal hypertension.Conclusions and Clinical ImportanceNeither the signalment of cats in this report nor the anatomy of their portovascular anomalies shared similarities with those cats previously identified with single‐vessel shunts. The relevance and etiology of these newly described splenosystemic shunts remain elusive and warrantsfurther investigation.}, number={6}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Palerme, J-S. and Brown, J. C. and Marks, S. L. and Birkenheuer, A. J.}, year={2013}, month={Nov}, pages={1347–1353} }