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Works (26)
Updated: October 1st, 2024 05:03
2024 journal article
MARCKS Inhibition Alters Bovine Neutrophil Responses to <i>Salmonella</i> Typhimurium
BIOMEDICINES, 12(2).
author keywords: neutrophils; Salmonella; MARCKS; respiratory burst; migration; phagocytosis
TL;DR:
This study demonstrates that MARCKS inhibition attenuated STm-induced neutrophil adhesion and chemotaxis and enhanced neutrophil phagocytosis and respiratory burst in response to STm, the first report describing the role of MARCKS protein in neutrophil antibacterial responses.
(via Semantic Scholar)
open access via www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 22, 2024
2024 article
Pathogenic diversification of the gut commensal <i>Providencia alcalifaciens</i> via acquisition of a second type III secretion system
Klein, J. A., Predeus, A. V., Greissl, A. R., Clark-Herrera, M. M., Cruz, E., Cundiff, J. A., … Knodler, L. A. (2024, September 10). INFECTION AND IMMUNITY.
author keywords: type III secretion; virulence; pathogenesis; enteric bacteria; diarrhea
Source: Web Of Science
Added: September 23, 2024
2023 article
Nonredundant Dimethyl Sulfoxide Reductases Influence Salmonella enterica Serotype Typhimurium Anaerobic Growth and Virulence
Cruz, E., Haeberle, A. L., Westerman, T. L., Durham, M. E., Suyemoto, M. M., Knodler, L. A., & Elfenbein, J. R. (2023, February 1). INFECTION AND IMMUNITY.
author keywords: DMSO; Salmonella; anaerobic metabolism; bovine ileal loop model; dimethyl sulfoxide; murine infection; type 3 secretion system
MeSH headings : Animals; Virulence; Anaerobiosis; Type III Secretion Systems / metabolism; Dimethyl Sulfoxide / pharmacology; Dimethyl Sulfoxide / metabolism; Serogroup; Oxidoreductases / metabolism; Salmonella typhimurium; Mammals
TL;DR:
It is demonstrated that an S. enterica serotype Typhimurium mutant with loss of function in all three putative DMSO reductases (ΔdmsA3) poorly colonizes the mammalian intestine when the microbiota is intact and when inflammation is absent, and suggest D MSO is a physiologically relevant electron acceptor that supports S. entersica fitness in the gut.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: March 13, 2023
2021 journal article
Sulfate Import in Salmonella Typhimurium Impacts Bacterial Aggregation and the Respiratory Burst in Human Neutrophils
INFECTION AND IMMUNITY, 89(6).
author keywords: Salmonella; cysteine metabolism; flagellar motility; neutrophils; respiratory burst
MeSH headings : Cysteine / metabolism; Flagella / physiology; Genes, Bacterial; Host-Pathogen Interactions / immunology; Humans; Mutation; Neutrophils / immunology; Neutrophils / metabolism; Respiratory Burst / immunology; Salmonella Infections / immunology; Salmonella Infections / microbiology; Salmonella typhimurium / physiology; Sulfates / metabolism; Type III Secretion Systems / genetics; Type III Secretion Systems / metabolism
TL;DR:
It is demonstrated that Salmonella Typhimurium has numerous mechanisms to limit the magnitude of the neutrophil respiratory burst, and this data further inform the understanding of howSalmonella may alter human neutrophIL antimicrobial defenses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021
2021 journal article
YeiE Regulates Motility and Gut Colonization in Salmonella enterica Serotype Typhimurium
MBIO, 12(3).
author keywords: Salmonella; flagellar gene regulation; gastrointestinal infection; host-pathogen interactions; transcriptional regulation
MeSH headings : Animals; Bacterial Proteins / genetics; Cattle; Female; Flagella / genetics; Flagella / physiology; Gastrointestinal Microbiome; Gene Expression; Gene Expression Regulation, Bacterial; Mice; Mice, Inbred C57BL; Movement; Salmonella Infections, Animal / microbiology; Salmonella typhimurium / genetics; Salmonella typhimurium / metabolism; Salmonella typhimurium / pathogenicity; Serogroup; Virulence
TL;DR:
It is indicated that YeiE promotes virulence by enhancing cell motility, thereby providing a new regulatory control point for flagellar expression in Salmonella Typhimurium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 27, 2021
2020 journal article
Comparative Genomics of Atypical Enteropathogenic Escherichia coli from Kittens and Children Identifies Bacterial Factors Associated with Virulence in Kittens
INFECTION AND IMMUNITY, 89(3).
author keywords: enteropathogenic E. coli; EPEC; animal model; phylogenetic analysis
MeSH headings : Adolescent; Animals; Cats / genetics; Child; Child, Preschool; Enteropathogenic Escherichia coli / genetics; Escherichia coli Infections / genetics; Escherichia coli Infections / microbiology; Escherichia coli Proteins / genetics; Female; Genetic Variation; Genomics; Humans; Infant; Infant, Newborn; Male; Serogroup; Serotyping; Virulence / genetics
TL;DR:
Kittens are identified as a host for aEPEC where intestinal epithelial colonization was associated with diarrheal disease and death and may provide a needed comparative animal model for the study of aEP EC pathogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 15, 2021
2020 journal article
Genetic Determinants of Salmonella Resistance to the Biofilm-Inhibitory Effects of a Synthetic 4-Oxazolidinone Analog
Applied and Environmental Microbiology, 86(20).
Ed(s): M. Kivisaar
author keywords: Salmonella; antimicrobial resistance; biofilm; genetics
MeSH headings : Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Drug Resistance, Bacterial / genetics; Oxazolidinones / pharmacology; Salmonella typhimurium / drug effects; Salmonella typhimurium / genetics
TL;DR:
The results of this study suggest that JJM-ox-3-70 inhibits biofilm formation by indirect inhibition of extracellular matrix production that may be linked to disruption of flagellar motility.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: November 16, 2020
2020 journal article
Linearized Siderophore Products Secreted via MacAB Efflux Pump Protect Salmonella enterica Serovar Typhimurium from Oxidative Stress
MBIO, 11(3).
author keywords: MacAB; Salmonella; multidrug efflux pump; siderophores
MeSH headings : ATP-Binding Cassette Transporters / genetics; ATP-Binding Cassette Transporters / metabolism; Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Biological Transport; Cattle; Enterobactin / analogs & derivatives; Enterobactin / metabolism; Female; Hydrogen Peroxide / pharmacology; Iron / metabolism; Mice; Mice, Inbred C57BL; Oxidative Stress; Peptide Biosynthesis, Nucleic Acid-Independent; Peptide Synthases / genetics; Reactive Oxygen Species / metabolism; Salmonella typhimurium / genetics; Salmonella typhimurium / metabolism; Siderophores / metabolism
TL;DR:
A new pathway used by Salmonella Typhimurium to detoxify extracellular reactive oxygen species using a multidrug efflux pump (MacAB) to secrete a linear siderophore, a metabolite of enterobactin, is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 12, 2020
2019 journal article
Disease features of equine coronavirus and enteric salmonellosis are similar in horses
Journal of Veterinary Internal Medicine, 33(2), 912–917.
author keywords: colic; equine coronavirus; fever; salmonella
MeSH headings : Animals; Betacoronavirus 1 / isolation & purification; Blood Cell Count / veterinary; Blood Chemical Analysis / veterinary; Communicable Diseases, Emerging; Coronavirus Infections / diagnosis; Coronavirus Infections / veterinary; Diagnosis, Differential; Feces / microbiology; Female; Horse Diseases / diagnosis; Horse Diseases / microbiology; Horses; Male; Retrospective Studies; Salmonella / isolation & purification; Salmonella Infections, Animal / diagnosis
TL;DR:
Equine coronavirus and Salmonella infections share clinical features, suggesting both diseases should be differential diagnoses for horses with fever and enteric clinical signs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: April 22, 2019
2019 journal article
Evaluation of vaporized hydrogen peroxide sterilization on the in vitro efficacy of meropenem-impregnated polymethyl methacrylate beads
AMERICAN JOURNAL OF VETERINARY RESEARCH, 80(1), 45–50.
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Horse Diseases / drug therapy; Horse Diseases / microbiology; Horses; Hydrogen Peroxide; In Vitro Techniques; Meropenem / pharmacology; Meropenem / therapeutic use; Microspheres; Osteomyelitis / drug therapy; Osteomyelitis / microbiology; Osteomyelitis / veterinary; Polymethyl Methacrylate / chemistry; Staphylococcal Infections / drug therapy; Staphylococcal Infections / microbiology; Staphylococcal Infections / veterinary; Staphylococcus aureus / drug effects; Sterilization / methods
TL;DR:
In vitro antimicrobial efficacy of M-PMMA beads was retained following VHP sterilization and the duration of antimicrobial elution in solid and liquid media did not differ significantly between unsterilization and VHP-sterilized M- PMMA beads.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 20, 2020
2019 article
Salmonella enterica
Knodler, L. A., & Elfenbein, J. R. (2019, November). TRENDS IN MICROBIOLOGY, Vol. 27, pp. 964–965.
MeSH headings : Animals; Humans; Phylogeny; Salmonella Infections / microbiology; Salmonella enterica / classification; Salmonella enterica / physiology
TL;DR:
This datasheet on Salmonella enterica covers Identity, Distribution, Hosts/Species Affected, and how to protect yourself and your family against infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: October 28, 2019
2018 journal article
Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10
CELL REPORTS, 23(12), 3525–3536.
MeSH headings : Adaptation, Physiological; Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacterial Secretion Systems; HeLa Cells; Host-Pathogen Interactions; Humans; Interleukin-10 / biosynthesis; Intracellular Space / microbiology; Mice, Inbred C57BL; Mutation / genetics; STAT3 Transcription Factor / metabolism; Salmonella enterica / growth & development; Salmonella enterica / pathogenicity; Salmonella enterica / physiology; Signal Transduction; Transcription, Genetic; Virulence
TL;DR:
RNA-seq of cells infected with either ΔsarA or wild-type S. Typhimurium revealed that SarA activates STAT3 transcriptional targets and contributes to intracellular replication in vitro and bacterial load at systemic sites in mice, demonstrating that Salmonella has evolved mechanisms for activating an important anti-inflammatory pathway.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
The Salmonella type-3 secretion system-1 and flagellar motility influence the neutrophil respiratory burst
PLOS ONE, 13(9).
MeSH headings : Fimbriae, Bacterial / physiology; Genotype; Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology; Humans; Interleukin-8 / pharmacology; Neutrophils / cytology; Neutrophils / metabolism; Neutrophils / microbiology; Reactive Oxygen Species / metabolism; Respiratory Burst / drug effects; Salmonella / genetics; Salmonella / metabolism; Type III Secretion Systems / drug effects; Type III Secretion Systems / metabolism
TL;DR:
It is demonstrated that both the type-3 secretion system-1 and flagellar motility, which are established virulence factors in enteric salmonellosis, also appear to directly influence the magnitude of the neutrophil respiratory burst in response to STm in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018
2016 journal article
Novel Two-Step Hierarchical Screening of Mutant Pools Reveals Mutants under Selection in Chicks
INFECTION AND IMMUNITY, 84(4), 1226–1238.
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Chickens; Evolution, Molecular; Gene Deletion; Gene Expression Regulation, Bacterial / physiology; Oligonucleotide Array Sequence Analysis; Poultry Diseases / microbiology; Salmonella Infections, Animal / microbiology; Salmonella typhimurium / genetics; Selection, Genetic
TL;DR:
A hierarchical screening strategy to interrogate large portions of the genome during infection of animals using pools of mutants of low complexity identified six genes not previously known to be needed during infection in chicks, and one of these suggests an important role for formate metabolism during infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Multicopy single-stranded DNA directs intestinal colonization of enteric pathogens
PLoS Genetics, 11(9).
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Systemic and anti-nociceptive effects of prolonged lidocaine, ketamine, and butorphanol infusions alone and in combination in healthy horses
BMC Veterinary Research, 10(Suppl 1), S6.
MeSH headings : Analgesics / administration & dosage; Analgesics / pharmacology; Anesthetics, Local / administration & dosage; Anesthetics, Local / pharmacology; Animals; Butorphanol / administration & dosage; Butorphanol / pharmacology; Drug Therapy, Combination; Gastrointestinal Motility / drug effects; Horses; Ketamine / administration & dosage; Ketamine / pharmacology; Lidocaine / administration & dosage; Lidocaine / pharmacology; Narcotic Antagonists / administration & dosage; Narcotic Antagonists / pharmacology; Nociception / drug effects
TL;DR:
Drug combinations containing butorphanol cause an apparent delay in gastrointestinal transit in healthy horses without substantially affecting somatic nociception at the doses studied.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2013 journal article
Novel Determinants of Intestinal Colonization of Salmonella enterica Serotype Typhimurium Identified in Bovine Enteric Infection
Infection and Immunity, 81(11), 4311–4320.
Ed(s): F. Fang
MeSH headings : Animals; Cattle; Cattle Diseases / microbiology; Disease Models, Animal; Gastroenteritis / microbiology; Gastroenteritis / veterinary; Gene Deletion; Genetic Complementation Test; Genetic Testing; Salmonella Infections, Animal / microbiology; Salmonella typhimurium / genetics; Salmonella typhimurium / pathogenicity; Virulence Factors / genetics; Virulence Factors / metabolism
TL;DR:
The genes identified in this study represent an exciting new class of virulence determinants for further mechanistic study to elucidate the strategies employed by Salmonella to survive within the small intestines of cattle.
(via Semantic Scholar)
Source: Crossref
Added: July 27, 2019
2012 journal article
Effect of butorphanol on thermal nociceptive threshold in healthy pony foals
Equine Veterinary Journal, 45(4), 503–506.
author keywords: horse; analgesia; somatic pain; behaviour; foal
MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacology; Animals; Butorphanol / administration & dosage; Butorphanol / pharmacology; Cross-Over Studies; Horse Diseases / etiology; Horse Diseases / prevention & control; Horses; Hot Temperature / adverse effects; Pain / etiology; Pain / prevention & control; Pain / veterinary; Pain Measurement / methods; Pain Measurement / veterinary
TL;DR:
Butorphanol shows analgesic potential in foals for management of somatic painful conditions and significantly increased thermal nociceptive threshold in neonatal and older foals without apparent adverse behavioural effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2012 journal article
Prevalence of gastric and duodenal ulceration in 691 nonsurviving foals (1995-2006)
Equine Veterinary Journal, 44, 76–79.
author keywords: horse; foal; gastric ulcer; antacid; retrospective; disease prevalence
MeSH headings : Animals; Duodenal Ulcer / epidemiology; Duodenal Ulcer / pathology; Duodenal Ulcer / veterinary; Florida / epidemiology; Horse Diseases / epidemiology; Horse Diseases / pathology; Horses; Prevalence; Retrospective Studies; Stomach Ulcer / epidemiology; Stomach Ulcer / pathology; Stomach Ulcer / veterinary
TL;DR:
The prevalence of ulcers in foals, although low, has remained stable over time and did not appear to be related to hospital-wide antacid medication use in neonates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2011 journal article
Pathology in Practice
Journal of the American Veterinary Medical Association, 238(11), 1417–1419.
MeSH headings : Animals; Desulfovibrionaceae Infections / pathology; Desulfovibrionaceae Infections / veterinary; Enteritis / pathology; Enteritis / veterinary; Fatal Outcome; Horse Diseases / pathology; Horses; Lawsonia Bacteria; Male
Source: Crossref
Added: July 27, 2019
2011 journal article
Systemic Effects of a Prolonged Continuous Infusion of Ketamine in Healthy Horses
Journal of Veterinary Internal Medicine, 25(5), 1134–1137.
author keywords: Analgesia; Behavior; Gastrointestinal; Motility
MeSH headings : Analgesics / administration & dosage; Analgesics / pharmacology; Animals; Feces; Female; Gastrointestinal Motility / drug effects; Gastrointestinal Transit / drug effects; Horses / metabolism; Horses / physiology; Infusions, Intravenous / veterinary; Ketamine / administration & dosage; Ketamine / pharmacology; Male
TL;DR:
Ketamine CRI delayed gastrointestinal transit time in healthy horses without effect on vital parameters and behavior scores and no significant differences detected between treatments in vital signs or gastrointestinal borborygmi.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2010 journal article
The Effects of Deferoxamine Mesylate on Iron Elimination after Blood Transfusion in Neonatal Foals
Journal of Veterinary Internal Medicine, 24(6), 1475–1482.
author keywords: Iron chelation; Neonatal isoerythrolysis
MeSH headings : Anemia, Hemolytic, Autoimmune / therapy; Anemia, Hemolytic, Autoimmune / veterinary; Animals; Animals, Newborn; Blood Transfusion / veterinary; Deferoxamine / therapeutic use; Female; Hemosiderosis / drug therapy; Hemosiderosis / veterinary; Horse Diseases / therapy; Horses; Iron / blood; Iron / metabolism; Male; Siderophores / therapeutic use
TL;DR:
Deferoxamine enhances urinary iron elimination and decreases hepatic iron accumulation after blood transfusion in foals and increases hematological, biochemical, and iron metabolism variables.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2009 journal article
Effect of detomidine on visceral and somatic nociception and duodenal motility in conscious adult horses
Veterinary Anaesthesia and Analgesia, 36(2), 162–172.
author keywords: alpha-2-adrenoreceptor agonist; analgesia; equine; sedation
MeSH headings : Animals; Area Under Curve; Dose-Response Relationship, Drug; Duodenum / drug effects; Female; Gastrointestinal Motility / drug effects; Half-Life; Horses / physiology; Hot Temperature; Hypnotics and Sedatives / pharmacology; Imidazoles / pharmacokinetics; Imidazoles / pharmacology; Male; Pain / drug therapy
TL;DR:
The lack of somatic anti-nociception as determined by TT testing may be related to the marked decrease in skin temperature, likely caused by peripheral vasoconstriction and the low temperature cut-off of the testing device.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2009 journal article
Pathology In Practice
Journal of the American Veterinary Medical Association, 235(4), 381–383.
MeSH headings : Animals; Diagnosis, Differential; Fatal Outcome; Female; Herpesviridae; Herpesviridae Infections / pathology; Herpesviridae Infections / veterinary; Horse Diseases / pathology; Horses; Inclusion Bodies, Viral; Intranuclear Inclusion Bodies; Lung Diseases, Interstitial / pathology; Lung Diseases, Interstitial / veterinary; Pulmonary Fibrosis / pathology; Pulmonary Fibrosis / veterinary
Source: Crossref
Added: July 27, 2019
2008 journal article
Effect of acepromazine, butorphanol, or N-butylscopolammonium bromide on visceral and somatic nociception and duodenal motility in conscious horses
American Journal of Veterinary Research, 69(5), 579–585.
MeSH headings : Acepromazine / pharmacology; Animals; Body Temperature / drug effects; Butorphanol / pharmacology; Butylscopolammonium Bromide / pharmacology; Duodenum / drug effects; Duodenum / physiology; Female; Gastrointestinal Motility / drug effects; Heart Rate / drug effects; Horses / physiology; Male; Muscarinic Antagonists / pharmacology; Pain Measurement / drug effects; Pain Measurement / methods; Pain Measurement / veterinary; Random Allocation; Respiration / drug effects
TL;DR:
Each drug caused predictable changes in sedation and vital signs, but consistent anti-nociceptive effects were not evident.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
2008 journal article
Hypoglycemia and Hyperlactatemia Associated with Lymphoma in an Angus Cow
Journal of Veterinary Internal Medicine, 22(6), 1441–1443.
MeSH headings : Animals; Cattle; Cattle Diseases / metabolism; Female; Hypoglycemia / complications; Hypoglycemia / veterinary; Lactates / blood; Lymphoma / complications; Lymphoma / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: July 27, 2019
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