Works (5)

Updated: July 5th, 2023 15:35

2022 journal article

The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia

MSPHERE, 7(2).

By: A. Reed n, J. Fletcher n, Y. Huang *, R. Thanissery n, A. Rivera n, R. Parsons n, A. Stewart  n, D. Kountz* ...

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: Clostridioides difficile; hydroxyproline; amino acids; Clostridia; Stickland reaction; colonization resistance; Stickland fermentation
MeSH headings : Animals; Clostridioides; Clostridioides difficile / genetics; Clostridium; Clostridium Infections / metabolism; Hydroxyproline / chemistry; Hydroxyproline / metabolism; Mice; Peptide Hydrolases; Proline / metabolism
Source: Web Of Science
Added: July 5, 2022

2021 journal article

Clostridioides difficile exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiota


By: J. Fletcher n, C. Pike n, R. Parsons n, A. Rivera n, M. Foley n, M. McLaren n , S. Montgomery *, C. Theriot n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
MeSH headings : Animals; Anti-Bacterial Agents / adverse effects; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacterial Toxins / genetics; Bacterial Toxins / immunology; Bacterial Toxins / metabolism; Bacteroides / drug effects; Bacteroides / metabolism; Clostridioides difficile / genetics; Clostridioides difficile / immunology; Clostridioides difficile / metabolism; Clostridium Infections / immunology; Clostridium Infections / microbiology; Clostridium Infections / pathology; Disease Models, Animal; Extracellular Matrix / metabolism; Female; Gastrointestinal Microbiome / drug effects; Gastrointestinal Microbiome / immunology; Gene Expression Regulation, Bacterial / immunology; Host-Pathogen Interactions / genetics; Host-Pathogen Interactions / immunology; Humans; Intestinal Mucosa / immunology; Intestinal Mucosa / microbiology; Intestinal Mucosa / pathology; Male; Matrix Metalloproteinases / metabolism; Mice; Nutrients / metabolism; Proteolysis; RNA, Bacterial / genetics; RNA, Bacterial / isolation & purification; RNA-Seq; Sigma Factor / genetics; Sigma Factor / immunology; Sigma Factor / metabolism; Transcriptome / immunology
Sources: Web Of Science, ORCID
Added: January 20, 2021

2019 article

Human fecal metabolomic profiling could inform Clostridioides difficile infection diagnosis and treatment

Theriot, C. M., & Fletcher, J. R. (2019, September 3). JOURNAL OF CLINICAL INVESTIGATION, Vol. 129, pp. 3539–3541.

By: C. Theriot* & J. Fletcher*

MeSH headings : Clostridioides difficile; Clostridium Infections; Diarrhea; Feces; Humans; Microbiota
Source: Web Of Science
Added: September 30, 2019

2018 journal article

Bacterial lipoproteins and other factors released by Francisella tularensis modulate human neutrophil lifespan: Effects of a TLR1 SNP on apoptosis inhibition


By: L. Kinkead*, L. Whitmore*, J. McCracken*, J. Fletcher*, B. Ketelsen*, J. Kaufman*, B. Jones*, D. Weiss *, J. Barker*, L. Allen *

co-author countries: United States of America πŸ‡ΊπŸ‡Έ
author keywords: apoptosis; lipoproteins; neutrophils; SNP; TLR2; tularaemia
MeSH headings : Apoptosis / physiology; Bacterial Proteins / metabolism; Francisella tularensis / genetics; Francisella tularensis / metabolism; Humans; Lipoproteins / metabolism; Macrophages / metabolism; Macrophages / microbiology; Macrophages / physiology; Neutrophils / metabolism; Neutrophils / microbiology; Neutrophils / physiology; Polymorphism, Single Nucleotide / genetics; Toll-Like Receptor 1 / genetics; Tularemia / metabolism; Tularemia / microbiology; Virulence / genetics; Virulence Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Shifts in the Gut Metabolome and Clostridium difficile Transcriptome throughout Colonization and Infection in a Mouse Model

MSPHERE, 3(2).

By: J. Fletcher n, S. Erwin n , C. Lanzas n  & C. Theriot n

co-author countries: United States of America πŸ‡ΊπŸ‡Έ

Contributors: J. Fletcher n, S. Erwin n , C. Lanzas n  & C. Theriot n

author keywords: Clostridium difficile; amino acids; intestinal colonization; metabolomics; peptides; transcriptomics
MeSH headings : Amino Acids, Branched-Chain / metabolism; Animals; Anti-Bacterial Agents / administration & dosage; Carbohydrate Metabolism; Cecum / microbiology; Clostridioides difficile / metabolism; Clostridium Infections / metabolism; Clostridium Infections / microbiology; Female; Gastrointestinal Microbiome; Gene Expression Profiling; Male; Mass Spectrometry; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Peptide Hydrolases / genetics; Proline / metabolism; Sequence Analysis, RNA; Transcriptome
Sources: Web Of Science, ORCID
Added: August 6, 2018