Works (15)

Updated: July 5th, 2023 16:02

2013 journal article

Extrauterine Listeriosis in the gravid mouse influences embryonic growth and development

PLoS One, 8(8).

By: M. Suyemoto, T. Hamrick, P. Spears, J. Horton, I. Washington, E. Havell, L. Borst, P. Orndorff

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Identification and Characterization of Two Bordetella avium Gene Products Required for Hemagglutination

INFECTION AND IMMUNITY, 78(6), 2370–2376.

By: L. Temple*, D. Miyamoto*, M. Mehta*, C. Capitini*, S. Von Stetina*, H. Barnes n, V. Christensen n, J. Horton n, P. Spears n, P. Orndorff n

MeSH headings : Animals; Antibodies, Bacterial / immunology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bordetella avium / pathogenicity; Cell Adhesion; Cells, Cultured; DNA Transposable Elements; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Epithelial Cells / microbiology; Erythrocytes / microbiology; Gene Order; Guinea Pigs; Hemagglutination; Hemagglutinins / genetics; Hemagglutinins / metabolism; Molecular Sequence Data; Mutagenesis, Insertional; Poultry Diseases / microbiology; Sequence Analysis, DNA; Sequence Deletion; Trachea / microbiology; Turkeys
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

A Listeria monocytogenes mutant defective in bacteriophage attachment is attenuated in orally inoculated mice and impaired in enterocyte intracellular growth

INFECTION AND IMMUNITY, 76(9), 4046–4054.

By: P. Spears n, M. Suyemoto n, A. Palermo n, J. Horton n, T. Hamrick*, E. Havell n, P. Orndorff n

MeSH headings : Animals; Bacterial Adhesion; Bacteriophages / physiology; DNA Transposable Elements; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Enterocytes / microbiology; Female; Genetic Complementation Test; Glycosyltransferases / genetics; Listeria monocytogenes / pathogenicity; Listeria monocytogenes / virology; Listeriosis / microbiology; Liver / microbiology; Mice; Mice, Inbred A; Molecular Sequence Data; Mutagenesis, Insertional; Receptors, Virus / genetics; Sequence Analysis, DNA; Spleen / microbiology; Survival Analysis; Viral Plaque Assay; Virulence; Virulence Factors / genetics; Virus Attachment
TL;DR: Interestingly, the glcV lesion, while preventing phage attachment, did not alter the mutant's ability to bind to cultured mouse enterocyte monolayers, rather, the mutation appeared to alter a subsequent step in intracellular replication measured by a reduction in plaque-forming efficiency and plaque size. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

The effect of preharvest calcium loading on tenderness of beef longissimus, supraspinatus and semitendinosus muscle

JOURNAL OF MUSCLE FOODS, 17(2), 155–164.

By: D. Hanson n, C. Calkins* & J. Horton*

TL;DR: CP drench, prior to harvest, may decrease shear force in beef longissimus muscle, andSerum calcium levels were higher and higher in muscle calcium or WBS values were detected among the treatments for semitendinosus and supraspinatus muscles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Effects of high dietary calcium propionate and dietary cation-anion balance on calcium metabolism and longissimus muscle tenderness in finishing steers

Professional Animal Scientists, 19(6), 424.

By: J. Spears*, T. Engle*, W. Platter*, K. Lloyd*, K. Belk* & J. Horton n

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Influence of extracellular bactericidal agents on bacteria within macrophages

INFECTION AND IMMUNITY, 71(2), 1016–1019.

By: T. Hamrick n, A. Diaz n, E. Havell n, . Horton n & P. Orndorff n

MeSH headings : Adhesins, Escherichia coli / metabolism; Animals; Anti-Bacterial Agents / pharmacology; Bacteriophage lambda / pathogenicity; Drug Resistance, Bacterial; Escherichia coli / drug effects; Escherichia coli / growth & development; Escherichia coli / virology; Fimbriae Proteins / metabolism; Gentamicins / pharmacology; Macrophages, Peritoneal / microbiology; Mice; Mice, Inbred BALB C; Phagocytosis
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Influence of pregnancy on the pathogenesis of listeriosis in mice inoculated intragastrically

INFECTION AND IMMUNITY, 71(9), 5202–5209.

By: T. Hamrick n, . Horton n, P. Spears n, E. Havell n, I. Smoak n & P. Orndorff n

MeSH headings : Animals; Base Sequence; Colon / microbiology; Colony Count, Microbial; DNA, Bacterial / genetics; Enterocytes / microbiology; Female; Listeria monocytogenes / genetics; Listeria monocytogenes / isolation & purification; Listeria monocytogenes / pathogenicity; Listeriosis / complications; Listeriosis / etiology; Liver / microbiology; Mice; Mutagenesis, Insertional; Pregnancy; Pregnancy Complications, Infectious / etiology; Risk Factors; Spleen / microbiology; Virulence / genetics
TL;DR: The ability of the 4nonb strain to produce a lethal infection in pregnant animals did not correlate with an increased incidence or level of liver and spleen colonization over that in nonpregnant females, but the lethality rate did correlate well with the rate at which embryos and their surrounding decidual covering became infected, suggesting that intrauterine infection could be responsible for the increased disease severity in the gravid females. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

The product of the fimI gene is necessary for Escherichia coli type 1 pilus biosynthesis

JOURNAL OF BACTERIOLOGY, 185(16), 5007–5011.

By: M. Valenski n, S. Harris n, P. Spears n, . Horton n & P. Orndorff n

MeSH headings : Adhesins, Escherichia coli / genetics; Adhesins, Escherichia coli / metabolism; Alleles; Escherichia coli / genetics; Escherichia coli / metabolism; Fimbriae Proteins / genetics; Fimbriae Proteins / metabolism; Fimbriae, Bacterial / metabolism; Frameshift Mutation; Genetic Complementation Test; Molecular Sequence Data; Mutagenesis, Insertional; Mutagenesis, Site-Directed
TL;DR: FimI has a required role in normal pilus biosynthesis and site-directed mutagenesis indicated that it produced polarity-like effects not seen with an in-frame fimI deletion mutation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Characterization of Escherichia coli type 1 pilus mutants with altered binding specificities

JOURNAL OF BACTERIOLOGY, 183(13), 4099–4102.

By: S. Harris n, P. Spears n, E. Havell n, T. Hamrick n, . Horton n & P. Orndorff n

MeSH headings : Adhesins, Bacterial / genetics; Adhesins, Bacterial / metabolism; Adhesins, Escherichia coli; Alleles; Chromosomes, Bacterial; Escherichia coli / physiology; Fimbriae Proteins; Fimbriae, Bacterial / genetics; Fimbriae, Bacterial / metabolism; Molecular Sequence Data; Mutation; Phenotype; Plasmids; Recombination, Genetic
TL;DR: PCR mutagenesis and a unique enrichment scheme were used to obtain two mutants, each with a single lesion in fimH, the chromosomal gene that encodes the adhesin protein (FimH) of Escherichia coli type 1 pili that were noteworthy in part because both were altered in the normal range of cell types bound by FimH. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Formation of antibiotic, biodegradable polymers by processing with Irgasan DP300R (Triclosan) and its inclusion compound with beta-cyclodextrin

Journal of Applied Polymer Science, 82(2), 300–309.

By: J. Lu n, M. Hill n, M. Hood n, D. Greeson n, J. Horton n, P. Orndorff n, A. Herndon n, A. Tonelli n

UN Sustainable Development Goal Categories
Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

p-nitrobenzoic acid alpha(2u) nephropathy in 13-week studies is not associated with renal carcinogenesis in 2-year feed studies

Toxicologic Pathology, 29(5), 507–513.

By: K. Williams n, J. Dunnick*, J. Horton*, A. Greenwell*, S. Eldridge*, M. Elwell*, R. Sills*

MeSH headings : Administration, Oral; Alpha-Globulins / analysis; Alpha-Globulins / metabolism; Animals; Carcinogenicity Tests; Cell Division / drug effects; Diet; Dose-Response Relationship, Drug; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / ultrastructure; Female; Hyalin / metabolism; Hyalin / ultrastructure; Immunohistochemistry; Kidney / drug effects; Kidney / metabolism; Kidney Diseases / chemically induced; Kidney Diseases / metabolism; Kidney Diseases / pathology; Kidney Tubules, Proximal / drug effects; Kidney Tubules, Proximal / metabolism; Kidney Tubules, Proximal / ultrastructure; Male; Microscopy, Electron; Nitrobenzoates / administration & dosage; Nitrobenzoates / toxicity; Rats; Rats, Inbred F344; Sex Factors
TL;DR: The minimal severity of nephropathy suggests that the degree of cytotoxicity was below the threshold, which would contribute to the development of renal tumors at 2 years. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Experimental Salmonella typhi infection in the domestic pig, Sus scrofa domestica

MICROBIAL PATHOGENESIS, 29(2), 121–126.

By: E. Metcalf*, G. Almond n, P. Routh n, . Horton n, R. Dillman n & P. Orndorff n

author keywords: Salmonella; typhi; choleraesuis; pig; tonsil; typhoid fever
MeSH headings : Animals; Disease Models, Animal; Female; Humans; Palatine Tonsil / microbiology; Salmonella / growth & development; Salmonella / pathogenicity; Salmonella Infections, Animal / microbiology; Salmonella typhi / growth & development; Salmonella typhi / pathogenicity; Swine; Swine Diseases / microbiology; Typhoid Fever / microbiology; Virulence
TL;DR: The observation of tonsillar involvement was consistent with former observations of S. choleraesuis and S. typhimurium infections in swine and supports a role for the tonsil in all porcine salmonella infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Genetic characterization of Escherichia coli type 1 pilus adhesin mutants and identification of a novel binding phenotype

JOURNAL OF BACTERIOLOGY, 182(14), 4012–4021.

By: T. Hamrick n, S. Harris n, P. Spears n, E. Havell n, . Horton n, P. Russell n, P. Orndorff n

MeSH headings : Adhesins, Bacterial / genetics; Adhesins, Escherichia coli; Animals; Bacterial Adhesion / genetics; Base Sequence; Chromosome Mapping; Erythrocytes / microbiology; Escherichia coli / genetics; Escherichia coli / pathogenicity; Fimbriae Proteins; Guinea Pigs; Hemagglutination Tests; Macrophages / microbiology; Mice; Molecular Sequence Data; Phenotype; Point Mutation
TL;DR: Temperature shift experiments revealed that new FimH biosynthesis was required for the phenotypic change, and a temperature-sensitive (ts) fimH mutant that agglutinated guinea pig erythrocytes but not at 42 degrees C was chosen for further study. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Host and bacterial factors involved in the innate ability of mouse macrophages to eliminate internalized unopsonized Escherichia coli

INFECTION AND IMMUNITY, 68(1), 125–132.

MeSH headings : Adhesins, Bacterial / immunology; Adhesins, Escherichia coli; Animals; Cell Line; Cytotoxicity, Immunologic; Escherichia coli / immunology; Fimbriae Proteins; Macrophages, Peritoneal / immunology; Macrophages, Peritoneal / microbiology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Phagocytosis; Species Specificity
TL;DR: Host and bacterial factors involved in the nonopsonic phagocytosis and killing of Escherichia coli K-12 by mouse macrophages were examined to better understand genetic and cellular factors that influence innate immunity and there was no correlation between the bacteriocidal effectiveness of amacrophage population and the number of bacteria bound per macrophage. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Formation of antibiotic, biodegradable/bioabsorbable polymers by processing with neomycin sulfate and its inclusion compound with beta-cyclodextrin

JOURNAL OF APPLIED POLYMER SCIENCE, 74(4), 937–947.

By: L. Huang n, H. Taylor n, M. Gerber n, P. Orndorff n, . Horton n & A. Tonelli n

TL;DR: Since an antibiotic, bioabsorbable suture does not require surgical removal, implanting an inclusion compound in the suture might allow the slow release of antibiotic, thereby guarding against postsurgical infection and also protecting the antibiotic from degradation during the melt-spinning process used to make the sutures. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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