Works (1099)

Updated: April 4th, 2024 17:58

2023 journal article

An artificial intelligence-assisted physiologically-based pharmacokinetic model to predict nanoparticle delivery to tumors in mice

JOURNAL OF CONTROLLED RELEASE, 361, 53–63.

author keywords: Artificial intelligence; Machine learning; Physiologically based pharmacokinetic; modeling; Nanomedicine; Drug delivery; Nanotechnology
TL;DR: An AI-assisted physiologically based pharmacokinetic (PBPK) model is established by integrating an AI-based quantitative structure-activity relationship (QSAR) model with a PBPK model to simulate tumor-targeted delivery efficiency (DE) and biodistribution of various NPs. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 7, 2023

2023 journal article

Development and application of an interactive generic physiologically based pharmacokinetic (igPBPK) model for adult beef cattle and lactating dairy cows to estimate tissue distribution and edible tissue and milk withdrawal intervals for per- and polyfluoroalkyl substances (PFAS)

FOOD AND CHEMICAL TOXICOLOGY, 181.

author keywords: Per-and polyfluoroalkyl substances (PFAS); Chemical residue; Interactive generic physiologically based pharmacokinetic (igPBPK) modeling; Withdrawal interval; Food safety; Risk assessment
Source: Web Of Science
Added: November 20, 2023

2023 journal article

Development of machine learning algorithms to estimate maximum residue limits for veterinary medicines

FOOD AND CHEMICAL TOXICOLOGY, 179.

author keywords: Unestablished MRL; Veterinary drugs; Machine learning; International market and trade; Published commodity (animal organ); Data resampling techniques
TL;DR: This study demonstrates unestablished MRLs can be reliably predicted for under-represented food commodity groups using machine learning (ML) and provides the first study to apply ML algorithms in regulatory food animal medicine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: September 25, 2023

2023 journal article

Meta-Analysis of Nanoparticle Distribution in Tumors and Major Organs in Tumor-Bearing Mice

ACS NANO, 17(20), 19810–19831.

author keywords: Nanoparticle; Tumor delivery; Tissue distribution; Cancer; Nanomedicine
TL;DR: An updated version of “Nano-Tumor Database” is reported, which increases the number of time-dependent concentration data sets for different nanoparticles (NPs) in tumors from the previous version of 376 data sets to 534 data sets with 2345 data points from 297 studies published from 2005 to 2021. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 10, 2023

2022 journal article

A web-based interactive physiologically based pharmacokinetic (iPBPK) model for meloxicam in broiler chickens and laying hens

FOOD AND CHEMICAL TOXICOLOGY, 168.

By: L. Yuan*, W. Chou*, E. Richards*, L. Tell*, R. Baynes n, J. Davis*, J. Riviere n, Z. Lin*

author keywords: Meloxicam; Food Animal Residue Avoidance Databank (FARAD); Physiologically based pharmacokinetic (PBPK) modeling; Broiler chicken; Laying hen; Food safety
MeSH headings : Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chickens; Eggs; Female; Internet; Meloxicam
TL;DR: The model provides a useful and flexible tool for risk assessment and management of residues for meat and eggs from chickens treated with meloxicam and will serve as a basis for extrapolation to other NSAID drugs and other poultry species to aid animal-derived food safety assessment. (via Semantic Scholar)
Source: Web Of Science
Added: December 12, 2022

2022 article

An Interactive Generic Physiologically Based Pharmacokinetic (igPBPK) Modeling Platform to Predict Drug Withdrawal Intervals in Cattle and Swine: A Case Study on Flunixin, Florfenicol, and Penicillin G

Chou, W.-C., Tell, L. A., Baynes, R. E., Davis, J. L., Maunsell, F. P., Riviere, J. E., & Lin, Z. (2022, June 1). TOXICOLOGICAL SCIENCES.

author keywords: drug residue; Food Animal Residue Avoidance Databank (FARAD); food safety; interactive generic physiologically based pharmacokinetic (igPBPK) model; withdrawal interval (WDI)
MeSH headings : Animals; Cattle; Clonixin / analogs & derivatives; Drug Residues / analysis; Drugs, Generic; Models, Biological; Penicillin G / pharmacokinetics; Swine; Thiamphenicol / analogs & derivatives
TL;DR: A user-friendly generic PBPK platform that can predict tissue residues and estimate WDIs for multiple drugs including flunixin, florfenicol, and penicillin G in cattle and swine is developed and provides a basis for extrapolating to other drugs and species. (via Semantic Scholar)
Source: Web Of Science
Added: June 20, 2022

2022 article

Mechanisms of toxicity and residue considerations of rodenticide exposure in food Animals-a FARAD perspective

Mercer, M. A., Davis, J. L., Riviere, J. E., Baynes, R. E., Tell, L. A., Jaberi-Douraki, M., … Lin, Z. (2022, March 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 260, pp. 514–523.

MeSH headings : Animals; Drug Residues; Rodenticides / toxicity
TL;DR: T Food Animal Residue Avoidance Databank (FARAD) frequently receives requests for withdrawal interval recommendations following inadvertent exposure of food animals to various environmental contaminants and pesticides such as rodenticides. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: March 28, 2022

2022 journal article

Predicting Nanoparticle Delivery to Tumors Using Machine Learning and Artificial Intelligence Approaches

INTERNATIONAL JOURNAL OF NANOMEDICINE, 17, 1365–1379.

By: Z. Lin, W. Chou, Y. Cheng*, C. He*, N. Monteiro-Riviere n & J. Riviere n

Contributors: Z. Lin, W. Chou, Y. Cheng*, C. He*, N. Monteiro-Riviere n & J. Riviere n

author keywords: artificial intelligence; machine learning; physiologically based pharmacokinetic modeling; nanomedicine; drug delivery; nanotechnology
MeSH headings : Artificial Intelligence; Humans; Machine Learning; Nanoparticles; Neoplasms / drug therapy; Neural Networks, Computer
TL;DR: The deep neural network model adequately predicted the delivery efficiency of different NPs to different tumors and it outperformed all other machine learning methods; including random forest, support vector machine, linear regression, and bagged model methods. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 30, 2022

2022 review

Toxicokinetics, dose-response, and risk assessment of nanomaterials: Methodology, challenges, and future perspectives

[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 14(6).

By: Q. Chen*, J. Riviere n & Z. Lin*

author keywords: dose-response assessment; nanomaterials; nanoparticles; risk assessment; toxicokinetics
MeSH headings : Animals; Humans; Toxicokinetics; Risk Assessment; Nanostructures / toxicity; Nanomedicine; Tissue Distribution
TL;DR: This article reviews the methods for conducting toxicokinetics, hazard identification, dose-response, exposure, and risk assessment studies of nanomaterials, identify the knowledge gaps, and discuss the challenges remaining and provides the rationale behind the appropriate design ofnanomaterial plasma toxicokinetic and tissue distribution studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: December 19, 2022

2022 journal article

Update on withdrawal intervals following extralabel use of procaine penicillin G in cattle and swine

Journal of the American Veterinary Medical Association, 260(1), 50–55.

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Cattle; Drug Residues; Penicillin G Procaine / therapeutic use; Swine
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 7, 2022

2021 content posted

Data-driven methodology for discovery and response to pulmonary symptomology in hypertension through AI and machine learning: Application to COVID-19 related pharmacovigilance

By: X. Xu*, J. Kawakami*, N. Millagaha Gedara*, J. Riviere n, E. Meyer*, G. Wyckoff*, M. Jaberi-Douraki*

Source: Crossref
Added: August 12, 2021

2021 journal article

Development and Application of an interactive Physiologically Based Pharmacokinetic (iPBPK) Model to Predict Oxytetracycline Tissue Distribution and Withdrawal Intervals in Market-Age Sheep and Goats

Toxicological Sciences, 183(2), 253–268.

By: M. Riad*, R. Baynes n, L. Tell*, J. Davis*, F. Maunsell*, J. Riviere n, Z. Lin*

author keywords: drug residue; Food Animal Residue Avoidance Databank (FARAD); food safety; interactive physiologically based pharmacokinetic (iPBPK) model; oxytetracycline; withdrawal interval (WDI)
MeSH headings : Animals; Anti-Bacterial Agents; Drug Residues / analysis; Goats; Models, Biological; Oxytetracycline; Sheep; Tissue Distribution
TL;DR: This iPBPK model provides a useful tool to estimate WDIs for OTC after extralabel use in small ruminants to ensure food safety and serves as a basis for extrapolation to other tetracycline drugs and other food animals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science
Added: August 12, 2021

2021 journal article

Honey bee medicine for veterinarians and guidance for avoiding violative chemical residues in honey

Journal of the American Veterinary Medical Association, 259(8), 860–873.

By: E. Richards*, L. Tell*, J. Davis*, R. Baynes n, Z. Lin*, F. Maunsell*, J. Riviere n, M. Jaberi-Douraki*, K. Martin*, G. Davidson n

MeSH headings : Animals; Bees; Honey; Humans; Veterinarians
TL;DR: People have long recognized and appreciated honey bees for their important role in pollinating commercial crops while also providing natural products for use in the food, cosmetic, and pharmaceutical industries. (via Semantic Scholar)
Source: NC State University Libraries
Added: May 21, 2022

2021 chapter

Percutaneous Absorption of Chemical Mixtures

In N. Dragićević (Ed.), Percutaneous Absorption (5th ed., pp. 305–314).

By: J. Riviere*

Ed(s): N. Dragićević

Source: Crossref
Added: August 12, 2021

2021 review

Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part II: Chicken and turkey

[Review of ]. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 44(4), 423–455.

By: Y. Wang*, M. Li*, L. Tell*, R. Baynes n, J. Davis*, T. Vickroy*, J. Riviere n, Z. Lin*

author keywords: blood flow; Food Animal Residue Avoidance Databank (FARAD); food safety; organ weight; physiologically based pharmacokinetic (PBPK) model
Source: Web Of Science
Added: December 21, 2020

2021 journal article

Pulmonary adverse drug event data in hypertension with implications on COVID-19 morbidity

SCIENTIFIC REPORTS, 11(1).

By: M. Jaberi-Douraki, E. Meyer, J. Riviere*, N. Gedara, J. Kawakami, G. Wyckoff, X. Xu*

MeSH headings : Angiotensin Receptor Antagonists / adverse effects; Angiotensin-Converting Enzyme Inhibitors / adverse effects; Antihypertensive Agents / adverse effects; COVID-19 / epidemiology; Comorbidity; Hospital Mortality; Humans; Hypertension / drug therapy; Hypertension / epidemiology; Indoles / adverse effects; Quinapril / adverse effects; Retrospective Studies; COVID-19 Drug Treatment
TL;DR: This study suggests that specific members of the ACEI antihypertensive class (quinapril and trandolapril) have a significantly higher cluster of pulmonary ADEs. (via Semantic Scholar)
Source: Web Of Science
Added: July 26, 2021

2020 journal article

A study to assess the correlation between plasma, oral fluid and urine concentrations of flunixin meglumine with the tissue residue depletion profile in finishing-age swine

BMC Veterinary Research, 16(1).

By: J. Bates*, L. Karriker*, S. Rajewski*, Z. Lin*, R. Gehring*, M. Li*, J. Riviere*, J. Coetzee*

author keywords: Flunixin meglumine; Food safety; Pharmacokinetics; Physiologically based pharmacokinetic (PBPK) model; Swine; Tissue residue
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / urine; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Clonixin / urine; Food Contamination / analysis; Pork Meat / analysis; Saliva / chemistry; Sus scrofa / physiology
TL;DR: Results indicate untreated pigs can be exposed to flunixin by shared housing with FM-treated pigs due to environmental contamination, and the PBPK model adequately correlated plasma, oral fluid and urine concentrations of flunxin with residue depletion profiles in liver, kidney, and muscle of finishing-age pigs, especially within 24 h after dosing. (via Semantic Scholar)
Source: Crossref
Added: August 13, 2021

2020 conference paper

Development and application of an interactive physiological based pharmacokinetic (iPBPK) model interface to estimate withdrawal intervals for penicillin G in cattle and swine

The Toxicologist, 174(1), 458.

By: Z. Lin, M. Li, R. Baynes, L. Tell, J. Davis, T. Vickroy, J. Riviere

Event: 59th Society of Toxicology annual meeting & ToxExpo at Anaheim, California on March 15-19, 2020

Source: NC State University Libraries
Added: August 13, 2021

2020 journal article

Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach

ACS Nano, 14(3), 3075–3095.

Contributors: Y. Cheng*, C. He*, J. Riviere*, N. Monteiro-Riviere* & Z. Lin*

author keywords: advanced material; drug delivery; nanomedicine; nanoparticle; physiologically based pharmacokinetic modeling; tissue biothstribution; tumor delivery
MeSH headings : Animals; Disease Models, Animal; Drug Carriers / chemistry; Drug Delivery Systems; Gold / administration & dosage; Gold / chemistry; Gold / pharmacokinetics; Injections, Intravenous; Male; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Neoplasms / chemistry; Neoplasms / metabolism; Tissue Distribution
TL;DR: The potential causes of this poor delivery efficiency were explored using the more mechanistic PBPK perspective applied to a subset of gold nanoparticles and it was found that low delivery efficiency was associated with low distribution and permeability coefficients at the tumor site. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: March 5, 2020

2020 journal article

Pharmacovigilance in patients with diabetes: A data-driven analysis identifying specific RAS antagonists with adverse pulmonary safety profiles that have implications for COVID-19 morbidity and mortality

Journal of the American Pharmacists Association, 60(6), e145–e152.

By: E. Stafford, J. Riviere*, X. Xu, J. Kawakami, G. Wyckoff & M. Jaberi-Douraki

MeSH headings : Angiotensin Receptor Antagonists / adverse effects; Angiotensin Receptor Antagonists / therapeutic use; Angiotensin-Converting Enzyme 2 / metabolism; Angiotensin-Converting Enzyme Inhibitors / adverse effects; Angiotensin-Converting Enzyme Inhibitors / therapeutic use; COVID-19 / complications; COVID-19 / metabolism; COVID-19 / mortality; China / epidemiology; Diabetes Mellitus / drug therapy; Diabetes Mellitus / metabolism; Diabetic Nephropathies / complications; Diabetic Nephropathies / metabolism; Diabetic Nephropathies / prevention & control; Humans; Morbidity / trends; Pharmacovigilance; Prevalence; Renin-Angiotensin System / drug effects; Respiratory System / drug effects; Respiratory System / metabolism; SARS-CoV-2
TL;DR: It is suggested that pharmacists and clinicians will need to consider specific medication’s adverse event profile, particularly captopril, and how this profile may affect infections and other acute disease states that alter pulmonary function, such as COVID-19. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 12, 2021

2020 journal article

Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part 1: Cattle and Swine

The Toxicologist, 174(1), 461.

By: M. Li, Y. Wang, L. Tell, R. Baynes, J. Davis, T. Vickroy, J. Riviere, Z. Lin

Event: 59th Society of Toxicology annual meeting & ToxExpo at Anaheim, California on March 15-19, 2020

Source: NC State University Libraries
Added: August 13, 2021

2020 review

Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and swine

[Review of ]. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 43(5), 385–420.

By: Z. Lin*, M. Li*, Y. Wang*, L. Tell*, R. Baynes n, J. Davis*, T. Vickroy*, J. Riviere n

author keywords: blood flow; food safety; organ weight; physiologically based pharmacokinetic model; withdrawal interval
MeSH headings : Animals; Cattle / physiology; Drug Residues; Models, Biological; Pharmaceutical Preparations / metabolism; Pharmacokinetics; Swine / physiology
TL;DR: These compiled data provide a comprehensive physiological parameter database for developing PBPK models of chemicals in cattle and swine to support animal‐derived food safety assessment and provide a basis to compile data in other food animal species, including goats, sheep, chickens, and turkeys. (via Semantic Scholar)
Source: Web Of Science
Added: August 31, 2020

2020 journal article

Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part III: Sheep and goat

Journal of Veterinary Pharmacology and Therapeutics, 44(4), 456–477.

author keywords: blood flow; food animal residue avoidance databank; food safety; organ weight; physiologically based pharmacokinetic model
MeSH headings : Animals; Cattle; Chickens; Goats; Models, Biological; Organ Size; Sheep; Swine
Source: Crossref
Added: August 13, 2021

2020 conference paper

Physiologically based pharmacokinetic modeling and simulation of nanoparticle delivery to tumors in mice

The Toxicologist, 174(1), 460.

By: Y. Cheng, C. He, J. Riviere, N. Monteiro-Riviere & Z. Lin

Event: 59th Society of Toxicology annual meeting & ToxExpo at Anaheim, California on March 15-19, 2020

Source: NC State University Libraries
Added: August 13, 2021

2019 journal article

An integrated experimental and physiologically based pharmacokinetic modeling study of penicillin G in heavy sows

Journal of Veterinary Pharmacology and Therapeutics, 42(4), 461–475.

By: M. Li*, C. Mainquist‐Whigham*, L. Karriker*, L. Wulf*, D. Zeng*, R. Gehring*, J. Riviere*, J. Coetzee*, Z. Lin*

author keywords: extralabel withdrawal interval; food safety; heavy sow; physiologically based pharmacokinetic (PBPK) model; procaine penicillin G (PPG); tissue residue
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Body Weight; Computer Simulation; Dose-Response Relationship, Drug; Drug Residues; Female; Models, Biological; Penicillin G / administration & dosage; Penicillin G / pharmacokinetics; Swine / blood; Swine / metabolism; Swine / urine
TL;DR: The results showed that antemortem testing of urine provided potential correlation with tissue residue levels and provided a tool to predict proper withdrawal intervals after extralabel use of penicillin G in heavy sows, thereby helping safety assessment of sow-derived meat products. (via Semantic Scholar)
Source: Crossref
Added: August 13, 2021

2019 conference paper

Assessing delivery efficiency of nanoparticles to tumors in tumor-bearing mice using a physiologically based pharmacokinetic modeling and simulation approach

The Toxicologist, 168(1), 476–477,

By: Y. Cheng, J. Riviere, N. Monteiro-Riviere & Z. Lin

Event: 58th Society of Toxicology annual meeting & ToxExpo at Baltimore, Maryland on March 10-14, 2019

Source: NC State University Libraries
Added: August 13, 2021

2019 journal article

Development and application of a population physiologically based pharmacokinetic model for florfenicol and its metabolite florfenicol amine in cattle

FOOD AND CHEMICAL TOXICOLOGY, 126, 285–294.

By: F. Yang n, Z. Lin*, J. Riviere n & R. Baynes n

author keywords: Physiologically based pharmacokinetic (PBPK) model; Withdrawal interval; Florfenicol; Florfenicol amine; Cattle
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Cattle; Cattle Diseases / drug therapy; China; Chromatography, High Pressure Liquid; Drug Administration Routes; Drug Residues / analysis; Drug Residues / metabolism; Drug Residues / pharmacokinetics; Kidney / drug effects; Liver / drug effects; Models, Biological; Thiamphenicol / administration & dosage; Thiamphenicol / analogs & derivatives; Thiamphenicol / analysis; Thiamphenicol / metabolism; Thiamphenicol / pharmacokinetics
TL;DR: A population physiologically based pharmacokinetic (PBPK) model to predict the concentrations of FF and its metabolite, florfenicol amine, in cattle after four different routes of administration, and to calculate and compare the withdrawal intervals (WDIs) with approved withdrawal times based on different marker residues and their MRLs or tolerances. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: April 15, 2019

2019 journal article

Extralabel drug use in wildlife and game animals

Journal of the American Veterinary Medical Association, 255(5), 555–568.

By: M. Clapham*, K. Martin*, J. Davis*, R. Baynes n, Z. Lin*, T. Vickroy*, J. Riviere n, L. Tell*

MeSH headings : Animals; Animals, Wild; Off-Label Use / veterinary
TL;DR: Wildlife or game animals will refer to free-ranging nondomesticated mammals, reptiles, and bird species as well as animals that are confined or farm raised and subsequently hunted for personal consumption or slaughtered for commercial purposes and thus are considered food-producing animals. (via Semantic Scholar)
Source: Crossref
Added: August 13, 2021

2019 conference paper

Integration of Food Animal Residue Avoidance Databank (FARAD) Empirical Methods for Drug Withdrawal Interval Determination with a Mechanistic Population-Based Interactive Physiologically Based Pharmacokinetic (iPBPK) Modeling Platform: Example for Flunixin Meglumine Administration

The Toxicologist, 168(1), 191.

By: M. Li, Y. Cheng, J. Chittenden, R. Baynes, L. Tell, J. Davis, T. Vickroy, J. Riviere, Z. Lin

Event: 58th Society of Toxicology annual meeting & ToxExpo at Baltimore, Maryland on March 10-14, 2019

Source: NC State University Libraries
Added: August 13, 2021

2019 journal article

Integration of Food Animal Residue Avoidance Databank (FARAD) empirical methods for drug withdrawal interval determination with a mechanistic population-based interactive physiologically based pharmacokinetic (iPBPK) modeling platform: example for flunixin meglumine administration

Archives of Toxicology, 93(7), 1865–1880.

By: M. Li*, Y. Cheng*, J. Chittenden n, R. Baynes n, L. Tell*, J. Davis*, T. Vickroy*, J. Riviere n, Z. Lin*

author keywords: Flunixin; Interactive physiologically based pharmacokinetic (iPBPK) model; Food safety; Drug residues; Withdrawal intervals (WDIs); Food Animal Residue Avoidance Databank (FARAD)
MeSH headings : Animals; Animals, Domestic / metabolism; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Databases, Factual; Drug Residues / pharmacokinetics; Food Contamination / analysis; Food Contamination / prevention & control; Food Safety / methods; Models, Biological; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: A new PBPK model for both cattle and swine after administration of flunixin meglumine was developed and it can be applied to develop new models for other drugs in other food animal species, thereby facilitating the application of P BPK modeling in WDI estimation and food safety assessment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science
Added: August 12, 2019

2019 journal article

Making Sense of Pharmacovigilance and Drug Adverse Event Reporting: Comparative Similarity Association Analysis Using AI Machine Learning Algorithms in Dogs and Cats

Topics in Companion Animal Medicine, 37, 100366.

By: X. Xu*, R. Mazloom*, A. Goligerdian*, J. Staley*, M. Amini*, G. Wyckoff*, J. Riviere*, M. Jaberi-Douraki*

author keywords: similarity association; drug adverse events; artificial intelligence; pharmacovigilance machine learning algorithms; graphical LASSO; companion animals
MeSH headings : Algorithms; Animals; Artificial Intelligence; Cats; Dogs; Drug Combinations; Drug-Related Side Effects and Adverse Reactions / veterinary; Ivermectin / adverse effects; Ivermectin / analogs & derivatives; Machine Learning; Macrolides / adverse effects; Pharmacovigilance
TL;DR: A comparative analysis of ADEs based on an artificial intelligence (AI) approach for the 5 robust similarity methods revealed high ADE associations for 2 drugs used in dogs and cats, and showed that the cosine method significantly outperformed all the other methods by correctly detecting and validating ADEs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 13, 2021

2019 journal article

Novel Data Sharing Agreement to Accelerate Big Data Translational Research Projects in the One Health Sphere

Topics in Companion Animal Medicine, 37, 100367.

By: J. Staley*, R. Mazloom*, P. Lowe*, C. Newsum*, M. Jaberi-Douraki*, J. Riviere*, G. Wyckoff*

author keywords: data sharing; one health; public-private partnership; data analysis; legal issues; translational research; big data
MeSH headings : Animals; Big Data; Data Anonymization; Health Insurance Portability and Accountability Act; Humans; Information Dissemination / methods; One Health; Translational Research, Biomedical / organization & administration; United States
TL;DR: The 1DATA Project examined and overcome some of the barriers to sharing data generated by researchers and clinicians working with for-profit companies, and the ways those obstacles can be surmounted via a novel form of Master Sharing Agreement are discussed. (via Semantic Scholar)
Source: Crossref
Added: August 13, 2021

2019 book

Science Breakthroughs to Advance Food and Agricultural Research by 2030

In SCIENCE BREAKTHROUGHS TO ADVANCE FOOD AND AGRICULTURAL RESEARCH BY 2030 (pp. 1–228).

By: D. Allison, C. Brown, L. Goddard, M. Guerinot, J. Jansson, L. Jaykus, H. Jensen, R. Khosla ...

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 24, 2020

2018 conference paper

A general physiologically-based pharmacokinetic model for gold nanoparticles of different sizes with multiple administration routes in rats

The Toxicologist, 162(1), 526.

By: Y. Cheng, J. Riviere, N. Monteiro-Riviere, W. Kreyling & Z. Lin

Event: 57th Society of Toxicology annual meeting and ToxExpo at San Antonio, Texas on March 11-15, 2018

Source: NC State University Libraries
Added: August 13, 2021

2018 chapter

Absorption, Distribution, Metabolism, and Elimination

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 8–40). Ames, Iowa: Wiley-Blackwell.

By: J. Riviere

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: August 13, 2021

2018 chapter

Aminoglycoside Antibiotics

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 877–902). Ames, Iowa: Wiley-Blackwell.

By: M. Papich & J. Riviere

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: August 13, 2021

2018 chapter

Antiarrhythmic Agents

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 537–552). Ames, Iowa: Wiley-Blackwell.

By: K. Meurs & J. Riviere

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: August 13, 2021

2018 conference paper

Application of population physiologically-based pharmacokinetic model for penicillin G in dairy cows to facilitate food safety assessment

The Toxicologist, 162(1), 526.

By: M. Li, R. Gehring, J. Riviere & Z. Lin

Event: 57th Society of Toxicology annual meeting at San Antonio, Texas on March 11-15, 2018

Source: NC State University Libraries
Added: August 13, 2021

2018 journal article

Automation and applications of the tolerance limit method in estimating meat withdrawal periods for veterinary drugs

COMPUTERS AND ELECTRONICS IN AGRICULTURE, 146, 125–135.

By: O. Udiani n, S. Mason*, G. Smith n, D. Mzyk n, R. Gehring*, L. Tell*, J. Riviere n, R. Baynes n

author keywords: Withdrawal time calculator; R studio; Maximum residue limit; Tolerance; US FDA
TL;DR: A novel program provides a platform to calculate a withdrawal period recommendation for any drug in any class of animal for various regulatory body standards and could be very helpful in cases of extra-label drug use in food animals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2018 chapter

Chemical Residues in Tissues of Food Animals

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 1469–1480). Ames, Iowa: Wiley-Blackwell.

By: J. Riviere

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: August 13, 2021

2018 journal article

Consequences of fipronil exposure in egg-laying hens

Journal of the American Veterinary Medical Association, 253(1), 57–60.

By: E. Stafford n, L. Tell, Z. Lin*, J. Davis*, T. Vickroy*, J. Riviere*, R. Baynes n

MeSH headings : Animal Feed / analysis; Animals; Chickens / metabolism; Europe; Female; Food Contamination / prevention & control; Food Safety; Ovum / metabolism; Pesticides / adverse effects; Pyrazoles / adverse effects
TL;DR: Concerns with fipronil use or exposure in poultry and the difficulties associated with developing data-driven meat or egg withdrawal intervals are explained. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 6, 2018

2018 chapter

Dermatopharmacology: Drugs Acting Locally on the Skin

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 1278–1301). Ames, Iowa: Wiley-Blackwell.

By: J. Riviere & R. Marsella

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: August 13, 2021

2018 chapter

Dosage Forms and Veterinary Feed Directives

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 1459–1464). Ames, Iowa: Wiley-Blackwell.

By: G. Smith & J. Riviere

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: August 13, 2021

2018 journal article

Editorial

Journal of Veterinary Pharmacology and Therapeutics, 41(3), 355–355.

By: J. Riviere n

MeSH headings : Editorial Policies; Periodicals as Topic; Veterinary Medicine
Sources: Web Of Science, Crossref
Added: August 6, 2018

2018 article

Extralabel drug use in small ruminants

Martin, K. L., Clapham, M. O., Davis, J. L., Baynes, R. E., Lin, Z., Vickroy, T. W., … Tell, L. A. (2018, October 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 253, pp. 1001–1009.

By: K. Martin*, M. Clapham*, J. Davis*, R. Baynes n, Z. Lin*, T. Vickroy*, J. Riviere n, L. Tell

MeSH headings : Animals; Drug Residues; Goat Diseases / drug therapy; Goats; Legislation, Drug; Off-Label Use; Sheep; Sheep Diseases / drug therapy; United States; United States Food and Drug Administration; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: The purpose of this digest is to update a previous FARAD Digest2 concerning small ruminants and provide veterinarians with summary information regarding ELDU in smallRuminants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 16, 2018

2018 conference paper

Impact of natural compounds on dermal absorption for consumer products and their computational prediction

The Toxicologist, 162(1), 179.

By: J. Riviere

Event: 57th Society of Toxicology annual meeting & ToxExpo at San Antonio, Texas on March 11-15, 2018

Source: NC State University Libraries
Added: August 13, 2021

2018 journal article

Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed-effects to characterize and quantify variability in drug pharmacokinetics

Journal of Veterinary Pharmacology and Therapeutics, 41(2), 171–183.

By: C. Bon*, P. Toutain*, D. Concordet, R. Gehring*, T. Martin-Jimenez*, J. Smith*, L. Pelligand*, M. Martinez* ...

author keywords: covariates; nonlinear mixed effects; population pharmacokinetics; sparse sampling; veterinary medicine
MeSH headings : Animal Diseases / drug therapy; Animals; Models, Theoretical; Nonlinear Dynamics; Pharmacokinetics
TL;DR: Nonlinear mixed effects (NLME) have been purposely designed to characterize the sources of variability in drug disposition and response and can be used to explore the impact of population-associated variables on the relationship between drug administration, systemic exposure, and the levels of drug residues in tissues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 13, 2021

2018 journal article

Modeling gold nanoparticle biodistribution after arterial infusion into perfused tissue: effects of surface coating, size and protein corona

Nanotoxicology, 12(10), 1093–1112.

By: J. Riviere*, M. Jaberi-Douraki*, J. Lillich*, T. Azizi*, H. Joo*, K. Choi*, R. Thakkar*, N. Monteiro-Riviere*

Contributors: J. Riviere*, M. Jaberi-Douraki*, J. Lillich*, T. Azizi*, H. Joo*, K. Choi*, R. Thakkar*, N. Monteiro-Riviere*

author keywords: Biodistribution; gold nanoparticles; cell uptake; skin; pharmacokinetics; nanoparticle vascular distribution
MeSH headings : Animals; Epigastric Arteries; Female; Free Tissue Flaps; Gold / administration & dosage; Gold / chemistry; Gold / pharmacokinetics; Humans; Infusions, Intra-Arterial; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Models, Biological; Nanomedicine; Particle Size; Perfusion; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / chemistry; Skin / blood supply; Skin / metabolism; Surface Properties; Swine; Thioctic Acid / chemistry; Tissue Distribution
TL;DR: These studies paralleled previous in vitro cell culture studies using the same AuNP in human endothelial and renal proximal tubule cells, hepatocytes, keratinocytes, showing BPEI-AuNP having the greatest uptake, although the presence of a PPC did not reduce IPPSF biodistribution as in the cellculture studies. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: June 27, 2019

2018 chapter

Pharmacokinetics

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 41–64). Ames, Iowa: Wiley-Blackwell.

By: J. Riviere

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: August 13, 2021

2018 journal article

Probabilistic Physiologically Based Pharmacokinetic Model for Penicillin G in Milk From Dairy Cows Following Intramammary or Intramuscular Administrations

Toxicological Sciences, 164(1), 85–100.

By: M. Li*, R. Gehring*, J. Riviere* & Z. Lin*

author keywords: PBPK modeling; dairy cows; food safety; drug residue; Food Animal Residue Avoidance Databank (FARAD); penicillin
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Cattle; Drug Residues / analysis; Female; Food Contamination / analysis; Injections, Intramuscular; Mammary Glands, Animal / metabolism; Meat / analysis; Milk / chemistry; Models, Biological; Penicillin G / administration & dosage; Penicillin G / pharmacokinetics
TL;DR: The current PBPK model can help predict milk discard interval for penicillin following extralabel use through IM and IMM administrations and showed that even 4 times label dose did not lead to violative tissue residues in healthy dairy cows with IMM infusions. (via Semantic Scholar)
Source: Crossref
Added: August 13, 2021

2018 journal article

Probabilistic risk assessment of gold nanoparticles after intravenous administration by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling

Nanotoxicology, 12(5), 453–469.

By: Y. Cheng*, J. Riviere*, N. Monteiro-Riviere* & Z. Lin*

Contributors: Y. Cheng*, J. Riviere*, N. Monteiro-Riviere* & Z. Lin*

author keywords: Gold nanoparticle; computational nanotoxicology; physiologically based pharmacokinetic modeling; probabilistic risk assessment
MeSH headings : Administration, Intravenous; Animals; Bayes Theorem; Gold / administration & dosage; Gold / pharmacokinetics; Gold / toxicity; Humans; Metal Nanoparticles / toxicity; Models, Biological; Monte Carlo Method; Risk Assessment
TL;DR: The results suggest that under the highest dosing level employed in existing animal studies (worst-case scenario), AuNPs coated with branched polyethylenimine (BPEI) would likely induce ∼90–100% cellular death, implying high cytotoxicity compared to <10% cell death induced by low-to-medium animal dosing levels, which are commonly used in animal studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, ORCID
Added: June 27, 2019

2018 conference paper

Probabilistic risk assessment of gold nanoparticles by integrating in vitro and in vivo toxicity with physiologically-based pharmacokinetic modeling

The Toxicologist, 162(1), 526.

By: Z. Lin, Y. Cheng, J. Riviere & N. Monteiro-Riviere

Event: 57th Society of Toxicology annual meeting and ToxExpo at San Antonio, Texas on March 11-15, 2018

Source: NC State University Libraries
Added: August 13, 2021

2018 chapter

Tetracycline Antibiotics

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 858–876). Ames, Iowa: Wiley-Blackwell.

By: M. Papich & J. Riviere

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: August 13, 2021

2018 journal article

Variation in fluoroquinolone pharmacodynamic parameter values among isolates of two bacterial pathogens of bovine respiratory disease

Scientific Reports, 8(1).

By: X. Wen*, R. Gehring*, J. Riviere*, B. Lubbers*, T. Gaire*, B. Wyche*, B. Fox*, V. Quichocho*, V. Volkova*

MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Bovine Respiratory Disease Complex / drug therapy; Bovine Respiratory Disease Complex / microbiology; Cattle; Fluoroquinolones / pharmacology; Fluoroquinolones / therapeutic use; Mannheimia haemolytica / drug effects; Mannheimia haemolytica / genetics; Mannheimia haemolytica / isolation & purification; Microbial Sensitivity Tests; Models, Biological; Pasteurella multocida / drug effects; Pasteurella multocida / genetics; Pasteurella multocida / isolation & purification; Phenotype
TL;DR: Investigating the fluoroquinolone enrofloxacin PD against different isolates of two bovine respiratory disease pathogens found variability in the PD parameters Hill-coefficient and Emax may impact the strain’s properties such as growth potential, which can have clinical implications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 13, 2021

2018 book

Veterinary Pharmacology and Therapeutics

(10th ed.). Ames, Iowa: Wiley-Blackwell.

Jim Riviere

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: August 13, 2021

2018 chapter

Veterinary Pharmacology: An Introduction to the Discipline

In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 3–7). Ames, Iowa: Wiley-Blackwell.

By: J. Riviere & M. Papich

Ed(s): J. Riviere & M. Papich

Source: NC State University Libraries
Added: August 13, 2021

2017 journal article

Avoiding violative flunixin meglumine residues in cattle and swine

Journal of the American Veterinary Medical Association, 250(2), 182–189.

By: P. Sidhu*, R. Gehring*, D. Mzyk n, T. Marmulak*, L. Tell, R. Baynes n, T. Vickroy*, J. Riviere*

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / chemistry; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Clonixin / analogs & derivatives; Clonixin / chemistry; Clonixin / pharmacokinetics; Drug Residues / pharmacokinetics; Swine
TL;DR: In the United States, NSAIDs are among the most frequently administered drugs for analgesia in cattle; however, such use is considered extralabel and must be in accordance with AMDUCA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2017 journal article

Biocorona formation on gold nanoparticles modulates human proximal tubule kidney cell uptake, cytotoxicity and gene expression

Toxicology in Vitro, 42, 150–160.

By: M. Ortega*, J. Riviere*, K. Choi* & N. Monteiro-Riviere*

author keywords: Gold nanoparticles; Human proximal tubule cells; Protein corona; Cellular uptake; Gene expression; Mechanisms of toxicity
MeSH headings : Cells, Cultured; Cytokines / metabolism; Gene Expression / drug effects; Gold / administration & dosage; Gold / chemistry; Gold / toxicity; Humans; Kidney Tubules, Proximal / cytology; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Plasma / chemistry; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / chemistry; Serum Albumin / chemistry; Thioctic Acid / chemistry
TL;DR: These studies clearly showed reduced uptake and cytotoxicity, as well as differentiated gene expression of AuNP with PCs, questioning the utility of in vitro studies using bare NP to assess in vivo effects, suggesting the relative safety of PEG and LA-AuNP as nanomedicine constructs. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: June 27, 2019

2017 journal article

Biological Surface Adsorption Index of Nanomaterials: Modelling Surface Interactions of Nanomaterials with Biomolecules

Advances in Experimental Medicine and Biology, 947, 207–253.

By: R. Chen* & J. Riviere*

author keywords: Nanoparticles; Surface interactions; BSAI; Bicorona; Physicochemistry; In situ characterization
MeSH headings : Adsorption; Environment; Models, Biological; Models, Theoretical; Nanostructures / chemistry; Nanotechnology / methods; Surface Properties
TL;DR: This chapter demonstrates the importance of the adsorption of surrounding molecules onto the surface of nanomaterials by forming biocorona and thus impact the bio-identity and fate of those materials. (via Semantic Scholar)
Source: Web Of Science
Added: February 5, 2022

2017 journal article

Considerations for extralabel drug use in calves

Journal of the American Veterinary Medical Association, 250(11), 1275–1282.

By: D. Mzyk*, R. Gehring, L. Tell, T. Vickroy, J. Riviere*, G. Ragan, R. Baynes*, G. Smith*

MeSH headings : Animals; Animals, Newborn; Cattle; Drug Labeling; Drug Residues; Food Contamination; Meat; Milk; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: The purpose of this digest is to provide veterinarians with a summary of the considerations for ELDU in both beef and dairy calves as well as calves intended for veal production. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 chapter

Dermatotoxicology: Computational approaches to predicting absorption of complex topical chemical mixtures

In S. Ekins (Ed.), Computational Toxicology (2nd ed., pp. 269–290). New York: John Wiley.

By: J. Riviere & J. Chittenden

Ed(s): S. Ekins

Source: NC State University Libraries
Added: February 5, 2022

2017 journal article

Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment

Food and Chemical Toxicology, 107, 74–87.

By: M. Li*, R. Gehring*, J. Riviere* & Z. Lin*

author keywords: Physiologically based pharmacokinetic (PBPK) model; Food safety; Food animal residue avoidance databank (FARAD); Penicillin; Drug residue; Extralabel withdrawal interval
MeSH headings : Animals; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacokinetics; Cattle; Drug Residues / chemistry; Drug Residues / pharmacokinetics; Food Safety; Kidney / chemistry; Liver / chemistry; Meat / analysis; Models, Biological; Muscle, Skeletal / chemistry; Penicillin G / chemistry; Penicillin G / pharmacokinetics; Swine
TL;DR: A physiologically based pharmacokinetic (PBPK) model is developed to predict drug residues in edible tissues and estimate extended withdrawal intervals for penicillin G in swine and cattle to aid food safety assessment and provide a framework for extrapolation to other food animal species. (via Semantic Scholar)
Source: Crossref
Added: October 1, 2021

2017 journal article

Guide to FARAD resources: historical and future perspectives

Journal of the American Veterinary Medical Association, 250(10), 1131–1139.

By: J. Riviere*, L. Tell, R. Baynes*, T. Vickroy & R. Gehring

MeSH headings : Animal Husbandry; Animals; Consumer Product Safety; Databases, Factual; Drug Residues; Food Contamination; Meat; United States; United States Department of Agriculture
TL;DR: The program has dramatically evolved since its inception in terms of data resources, outreach, quantitative tools used to estimate WDIs, precision of estimates, and methods implemented to disseminate information. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science
Added: August 6, 2018

2017 journal article

Modulation of topical chemical absorption by 14 natural compounds: a quantitative structure permeation (QSPR) analysis of components often found in topical preparations

Cutaneous and Ocular Toxicology, 36(3), 237–252.

By: F. Muhammad, M. Jaberi-Douraki, D. de Sousa & J. Riviere

Source: NC State University Libraries
Added: February 5, 2022

2017 chapter

Multi-Walled Carbon Nanotube Exposure Alters Protein Expression in Human Keratinocytes

In Nanomedicine in Cancer (pp. 461–485).

By: F. Witzmann & N. Monteiro-Riviere

Source: Crossref
Added: December 24, 2021

2017 journal article

Nano in-vitro cellular uptake simulator (NICUS): a model to quantitate nanomaterial endocytosis kinetics and intracellular dose

The Toxicologist, 156, 303.

By: Z. Lin, M. Jaberi-Douraki, N. Monteiro-Riviere & J. Riviere

Source: NC State University Libraries
Added: February 5, 2022

2017 journal article

NanoEHS beyond toxicity – focusing on biocorona

Environmental Science: Nano, 4(7), 1433–1454.

TL;DR: New opportunities concerning nano-biomolecular interactions beyond the scope of toxicity are highlighted, which presents vast new opportunities for screening beneficial material properties and designing greener products from bottom up. (via Semantic Scholar)
Source: Crossref
Added: October 1, 2021

2017 journal article

Performance Assessment and Translation of Physiologically Based Pharmacokinetic Models From acslX to Berkeley Madonna, MATLAB, and R Language: Oxytetracycline and Gold Nanoparticles As Case Examples

Toxicological Sciences, 158(1), 23–35.

By: Z. Lin*, M. Jaberi-Douraki*, C. He*, S. Jin*, R. Yang*, J. Fisher*, J. Riviere*

author keywords: acslX; Berkeley Madonna; MATLAB; PBPK modeling; R language
MeSH headings : Animals; Dogs; Gold / blood; Gold / chemistry; Gold / pharmacokinetics; Metal Nanoparticles / chemistry; Models, Biological; Oxytetracycline / blood; Oxytetracycline / pharmacokinetics; Swine; Tissue Distribution
TL;DR: This tutorial helps beginners learn PBPK modeling, provides suggestions for selecting a suitable tool for future projects, and may lead to the transition from acslX to alternative modeling tools. (via Semantic Scholar)
Source: Crossref
Added: October 1, 2021

2017 journal article

Pharmacokinetics of Mequindox and Its Marker Residue 1,4-Bisdesoxymequindox in Swine Following Multiple Oral Gavage and Intramuscular Administration: An Experimental Study Coupled with Population Physiologically Based Pharmacokinetic Modeling

Journal of Agricultural and Food Chemistry, 65(28), 5768–5777.

author keywords: food safety; mequindox; physiologically based pharmacokinetic (PBPK) modeling; quinoxaline-N,N-dioxide antibiotics; swine
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Drug Residues / pharmacokinetics; Injections, Intramuscular; Liver / metabolism; Quinoxalines / administration & dosage; Quinoxalines / pharmacokinetics; Swine; Tissue Distribution; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: A flow-limited physiologically based pharmacokinetic (PBPK) model can be used to predict depletion kinetic profiles and tissue residues of MEQ's marker residue M1 in swine and as a foundation for scaling to other quinoxaline-N,N-dioxide antibiotics and to other animal species. (via Semantic Scholar)
Source: Crossref
Added: October 1, 2021

2017 journal article

Surface chemistry of gold nanoparticles determines the biocorona composition impacting cellular uptake, toxicity and gene expression profiles in human endothelial cells

Nanotoxicology, 11(4), 507–519.

By: P. Chandran*, J. Riviere* & N. Monteiro-Riviere*

Contributors: P. Chandran*, J. Riviere* & N. Monteiro-Riviere*

author keywords: Biocorona; gold nanoparticles; surface chemistry; endothelial cells; mechanistic toxicology
MeSH headings : Albumins / metabolism; Cell Survival / drug effects; Circular Dichroism; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Gold / chemistry; Gold / toxicity; Human Umbilical Vein Endothelial Cells; Humans; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Particle Size; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / metabolism; Proteomics; Surface Properties; Transcriptome / drug effects
TL;DR: NP surface chemistry is shown to play the dominant role over size in determining the biocorona composition, which in turn modulates cell uptake, and biological responses, consequently defining the potential safety and efficacy of nanoformulations. (via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: April 29, 2021

2017 journal article

Zinc Oxide Nanoparticle–Poly I:C RNA Complexes: Implication as Therapeutics against Experimental Melanoma

Molecular Pharmaceutics, 14(3), 614–625.

By: M. Ramani, M. Mudge*, R. Morris*, Y. Zhang, S. Warcholek, M. Hurst*, J. Riviere*, R. DeLong*

author keywords: zinc oxide nanoparticles (ZnO-NPs); poly I:C RNA (pIC); binding parameters; antimelanoma; immunology
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Biomarkers, Tumor / metabolism; Cell Death / drug effects; Cell Line, Tumor; Humans; Interferon-gamma / metabolism; Interleukin-6 / metabolism; MAP Kinase Kinase 4 / metabolism; Melanoma, Experimental / drug therapy; Melanoma, Experimental / metabolism; Mice; Mice, Inbred BALB C; Nanoparticles / administration & dosage; Poly I-C / pharmacology; Proto-Oncogene Proteins c-akt / metabolism; RNA / pharmacology; Zinc Oxide / pharmacology
TL;DR: High throughput proteomics analysis revealed zinc oxide and poly I:C-specific and combinational patterns that suggested possible utility as an anticancer and immunotherapeutic strategy against melanoma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: October 1, 2021

2016 journal article

A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles

Nanomedicine, 11(2), 107–119.

By: Z. Lin*, N. Monteiro-Riviere*, R. Kannan* & J. Riviere*

Contributors: Z. Lin*, N. Monteiro-Riviere*, R. Kannan* & J. Riviere*

author keywords: biodistribution; computational nanotoxicology; endocytosis; nanomaterials; PBPK modeling; physiologically based pharmacokinetic modeling; phagocytosis; toxicokinetics
MeSH headings : Animals; Cell Survival / drug effects; Computer Simulation; Dose-Response Relationship, Drug; Environmental Exposure / adverse effects; Gold / pharmacokinetics; Gold / toxicity; Humans; Metabolic Clearance Rate; Mice; Models, Biological; Nanoparticles / toxicity; Rats; Species Specificity; Swine; Tissue Distribution; Toxicity Tests / methods
TL;DR: These results partially explain the current low translation rate of nanotechnology-based drug delivery systems from mice to humans and may be applied to other nanomaterials and provides guidance to design future translational studies. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID, NC State University Libraries
Added: April 29, 2021

2016 journal article

A new voyage begins: welcoming new editors and the launching of Pharmacokinetic Reports

Journal of Veterinary Pharmacology and Therapeutics, 39, 317.

By: J. Riviere

Source: NC State University Libraries
Added: February 5, 2022

2016 journal article

A physiological based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice

Nanotoxicology, 10, 162–172.

By: Z. Lin, N. Monteiro-Riviere & J. Riviere

Source: NC State University Libraries
Added: February 5, 2022

2016 journal article

Assessment of penetrant and vehicle mixture properties on transdermal permeability using a mixed effect pharmacokinetic model of ex vivo porcine skin

Biopharmaceutics & Drug Disposition, 37(7), 387–396.

By: J. Chittenden n & J. Riviere*

author keywords: quantitative structure property relationship; transdermal permeability; vehicle mixture; ex vivo; mixed-effect model
MeSH headings : Administration, Cutaneous; Animals; Models, Biological; Permeability; Pharmaceutical Preparations / metabolism; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption; Swine
TL;DR: A mixed effect, pharmacokinetic tissue model was used to model finite dose, transdermal, absorption data from IPPSF experiments for 12 penetrants dosed in up to 10 different vehicles and was able to identify permeability constant, while accounting for between and within unit variability, across the entire data set. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018

2016 journal article

Biological and environmental surface interactions of nanomaterials: characterization, modeling, and prediction

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 9(3), e1440.

By: R. Chen* & J. Riviere*

MeSH headings : Animals; Biocompatible Materials; Biomedical Research; Humans; Mice; Models, Theoretical; Molecular Dynamics Simulation; Nanostructures; Structure-Activity Relationship; Surface Properties
TL;DR: To quantitatively decipher these physicochemical surface interactions, computational methods can be used for either analyses of large amounts of experimental characterization data, or theoretical prediction of the interactions, and consequent biological behavior in the body after administration. (via Semantic Scholar)
Source: Crossref
Added: September 30, 2021

2016 conference paper

Biological surface adsorption index: environmental applications and parallel molecular dynamics simulations

Proceedings of 8th International Nanotoxicology Conference, 72.

By: R. Chen, J. Comer & J. Riviere

Event: 8th International Nanotoxicology Conference

Source: NC State University Libraries
Added: February 5, 2022

2016 conference paper

Caveats to making in vitro to in vivo and interspecies extrapolations of nanoparticle biological interactions using in silico computational modeling

The 51st Midwest Regional Meeting of the American Chemical Society, 47.

By: J. Riviere

Event: 51st Midwest Regional Meeting of the American Chemical Society at Orlando, FL

Source: NC State University Libraries
Added: February 5, 2022

2016 journal article

Estimation of tulathromycin depletion in plasma and milk after subcutaneous injection in lactating dairy goats using a nonlinear mixed-effect pharmacokinetic modeling approach

BMC Veterinary Research, 12(258).

By: Z. Lin, M. Cuneo, J. Rowe, M. Li, L. Tell, S. Allison, J. Carlson, J. Riviere, R. Gehring

Source: NC State University Libraries
Added: February 5, 2022

2016 journal article

Exploring Post-Treatment Reversion of Antimicrobial Resistance in Enteric Bacteria of Food Animals as a Resistance Mitigation Strategy

Foodborne Pathogens and Disease, 13(11), 610–617.

By: V. Volkova*, B. KuKanich* & J. Riviere*

author keywords: pre-harvest food safety; antimicrobial use in livestock; antimicrobial resistance in bacteria of animal origin; antimicrobial resistance ecology; population pharmacokinetics
MeSH headings : Animals; Anti-Infective Agents / adverse effects; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / therapeutic use; Drug Residues / standards; Drug Residues / toxicity; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae / drug effects; Enterobacteriaceae / growth & development; Enterobacteriaceae / isolation & purification; Enterobacteriaceae Infections / drug therapy; Enterobacteriaceae Infections / microbiology; Enterobacteriaceae Infections / prevention & control; Enterobacteriaceae Infections / veterinary; Escherichia coli / drug effects; Escherichia coli / growth & development; Escherichia coli / isolation & purification; Escherichia coli Infections / drug therapy; Escherichia coli Infections / microbiology; Escherichia coli Infections / prevention & control; Escherichia coli Infections / veterinary; Evidence-Based Practice; Feces / microbiology; Food Contamination / prevention & control; Food Safety; Foodborne Diseases / drug therapy; Foodborne Diseases / microbiology; Foodborne Diseases / prevention & control; Guidelines as Topic; Humans; Livestock / growth & development; Livestock / microbiology; Secondary Prevention / standards; Tissue Distribution
TL;DR: It is hypothesize that it is possible to define the distribution of the time period after treatment within which resistance to the administered drug, and possibly other drugs in case of coselection, in fecal bacteria of the treated animals returns to the background pre-treatment levels. (via Semantic Scholar)
Source: Crossref
Added: October 1, 2021

2016 journal article

Health concerns and management of select veterinary drug residues

Food and Chemical Toxicology, 88, 112–122.

By: R. Baynes n, K. Dedonder*, L. Kissell n, D. Mzyk n, T. Marmulak*, G. Smith n, L. Tell*, R. Gehring*, J. Davis n, J. Riviere*

author keywords: Drug; Veterinary; Residue; Adverse; Livestock
MeSH headings : Animals; Carcinogens; Drug Residues / adverse effects; Humans; Veterinary Drugs / chemistry; Veterinary Drugs / metabolism; Veterinary Drugs / pharmacokinetics
TL;DR: The aim of this manuscript is to review the potential adverse health effects in humans if exposed to residues of selected veterinary drugs used in food-producing animals and how regulatory and independent organizations manage the risk of these veterinary drugs based on data from human health risk assessments. (via Semantic Scholar)
Sources: Crossref, ORCID
Added: February 24, 2020

2016 journal article

Human food safety implications of variation in food animal drug metabolism

Scientific Reports, 6(27907).

By: Z. Lin, C. Vahl & J. Riviere

Source: NC State University Libraries
Added: February 5, 2022

2016 journal article

Influence of some plant extracts on the transdermal absorption and penetration of marker residues

Cutaneous and Ocular Toxicology, 30, 1–7.

By: F. Muhammad, J. Wiley & J. Riviere

Source: NC State University Libraries
Added: February 5, 2022

2016 journal article

Limitation of MIC as sole metric of pharmacodynamic response across the range of antimicrobial susceptibility within a single bacterial species

Scientific Reports, 6(37907).

By: X. Wen, R. Gehring, A. Stallbaumer & J. Riviere

Source: NC State University Libraries
Added: February 5, 2022

2016 journal article

Mathematical modeling and simulation in animal health – Part II : principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment

Journal of Veterinary Pharmacology and Therapeutics, 39(5), 421–438.

By: Z. Lin*, R. Gehring*, J. Mochel*, T. Lavé* & J. Riviere*

MeSH headings : Animals; Food Safety / methods; Models, Statistical; Pharmacokinetics; Veterinary Medicine / methods; Veterinary Medicine / statistics & numerical data
TL;DR: This review provides a comprehensive summary of PBPK modeling principles, model development methodology, and the current applications in veterinary medicine, with a focus on predictions of drug tissue residues and withdrawal times in food-producing animals. (via Semantic Scholar)
Source: Crossref
Added: October 1, 2021

2016 journal article

Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics

Journal of Veterinary Pharmacology and Therapeutics, 39(3), 213–223.

By: J. Riviere*, J. Gabrielsson*, M. Fink* & J. Mochel*

MeSH headings : Animals; Computer Simulation; Models, Biological; Veterinary Drugs / pharmacokinetics
TL;DR: Concepts and approaches to modeling and simulation based on solid physiological and pharmacological principles as well as adhering to the limitations that are fundamental to applying mathematical and statistical models to biological systems are introduced. (via Semantic Scholar)
Source: Crossref
Added: October 1, 2021

2016 journal article

Mechanistic Toxicity Assessment of Hexahydroisohumulone in Canine Hepatocytes, Renal Proximal Tubules, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells

International Journal of Veterinary Health Science & Research, 4(2), 88–103.

By: K. Choi, J. Koci, M. Ortega, B. Jeffery, J. Riviere* & N. Monteiro Riviere

TL;DR: Investigating organ-specific oxidative stress and the molecular mechanism of toxicity using the pathway-focused DNA array of the hop ingredient hexahydroisohumulone with canine hepatocytes, canine proximal tubule cells, bone marrow-derived mesenchymal stem cells and enterocyte-like cells provides insight into genes altered with HEX exposure and the cell-type specific responses in dogs. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 29, 2021

2016 journal article

Mechanistic toxicity assessment of hexahydroisohumulone in canine hepatocytes, renal proximal tubules, and enterocyte like-cells

The Toxicologist, 150, 487.

By: K. Choi, J. Koci, M. Ortega, B. Jeffery, J. Riviere & N. Monteiro-Riviere

Source: NC State University Libraries
Added: February 5, 2022

2016 journal article

Modulation of Chemical Dermal Absorption by 14 Natural Products: A Quantitative Structure Permeation (QSPR) Analysis of Components Often Found in Topical Cosmeceuticals

Cutaneous and Ocular Toxicology, 36(3), 237–252.

By: F. Muhammad*, M. Jaberi-Douraki*, D. de Souza & J. Riviere*

author keywords: Absorption; compounds of natural origin; mathematical modeling; mixtures; QSPR; skin
MeSH headings : Administration, Topical; Animals; Biological Products / chemistry; Biological Products / pharmacology; Caffeine / chemistry; Caffeine / pharmacokinetics; Cosmetics / chemistry; Cosmetics / pharmacokinetics; Female; In Vitro Techniques; Models, Biological; Permeability; Quantitative Structure-Activity Relationship; Salicylic Acid / chemistry; Salicylic Acid / pharmacokinetics; Skin / metabolism; Skin Absorption / drug effects; Swine
TL;DR: Modulation of dermal absorption of model components often found in topical preparations by a set of 14 compounds of natural origin using a flow through in vitro porcine skin diffusion system confirms that some natural products incorporated into topical formulations will enhance absorption of other components which could affect their safety and efficacy profiles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: February 5, 2022

2016 journal article

Observations on macrolide resistance in field isolates collected from bovine respiratory disease cases

Veterinary Microbiology, 192, 186–193.

By: K. DeDonder, D. Harhay, M. Apley, B. Lubbers, M. Clawson, G. Schuller, G. Harhay, B. White ...

Source: NC State University Libraries
Added: February 5, 2022

2016 journal article

Oxidative stress response in canine in vitro liver, kidney and intestinal models with seven potential dietary ingredients

Toxicology Letters, 241, 49–59.

By: K. Choi*, M. Ortega*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

Contributors: K. Choi*, M. Ortega*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

author keywords: In vitro canine culture systems; Multiple organ-derived cells; Dietary ingredients; Organ-specific oxidative stress
MeSH headings : Animals; Antioxidants / chemistry; Antioxidants / pharmacology; Bone Marrow Cells / drug effects; Bone Marrow Cells / metabolism; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Food; Food Analysis; Hepatocytes / drug effects; Intestinal Mucosa / metabolism; Intestines / drug effects; Kidney / drug effects; Kidney / metabolism; Kidney Tubules, Proximal / cytology; Kidney Tubules, Proximal / drug effects; Liver / drug effects; Liver / metabolism; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Oxidants / toxicity; Oxidative Stress / drug effects
TL;DR: The results suggest that organ-specific responses to oxidative stress by these potential prooxidant compounds may implicate a mechanism of their toxicities. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021

2016 journal article

Pharmacokinetics and tissue elimination of flunixin in veal calves

American Journal of Veterinary Research, 77(6), 634–640.

By: L. Kissell n, P. Brinson n, R. Gehring*, L. Tell, S. Wetzlich*, R. Baynes n, J. Riviere*, G. Smith n

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / chemistry; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Cattle / blood; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / chemistry; Clonixin / metabolism; Clonixin / pharmacokinetics; Drug Residues; Half-Life; Liver / chemistry; Muscle, Skeletal / chemistry; Muscle, Skeletal / metabolism
TL;DR: Results indicated that a slaughter withdrawal interval of several weeks may be necessary to ensure that violative tissue residues of flunixin are not detected in veal calves treated with that drug. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 conference paper

Physiological based pharmacokinetic (PBPK) modeling of nanomaterials: Why is quantitation and anatomical / physiological reality so important?

Proceedings of 8th International Nanotoxicology Conference, 385.

By: J. Riviere

Event: 8th International Nanotoxicology Conference

Source: NC State University Libraries
Added: February 5, 2022

2016 chapter

Potential mechanism of toxicity of hexahydroisohumulone in an in vitro canine model

Presented at the WINNS 2016 – Growing Science in Pet Nutrition.

By: B. Jeffrey, N. Monteiro-Riviere, D. Mitchel, K. Choi, K. Koci & J. Riviere

Event: WINNS 2016 – Growing Science in Pet Nutrition

Source: NC State University Libraries
Added: February 5, 2022

2016 conference paper

Predicting and modeling in vivo nanoparticle biodistribution: caveats to making in vitro and rodent interspecies extrapolations

11th International Particle Toxicology Conference, 54.

By: J. Riviere & N. Monteiro-Riviere

Event: 11th International Particle Toxicology Conference

Source: NC State University Libraries
Added: February 5, 2022

2016 journal article

Protein corona modulation of hepatocyte uptake and molecular mechanisms of gold nanoparticle toxicity

Nanotoxicology, 11(1), 64–75.

By: K. Choi*, J. Riviere* & N. Monteiro-Riviere*

Contributors: K. Choi*, J. Riviere* & N. Monteiro-Riviere*

author keywords: Gold nanoparticles; human hepatocytes; cell uptake; cytochrome P450; mechanisms of action
MeSH headings : Albumins / chemistry; Blood Proteins / chemistry; Cell Survival / drug effects; Dose-Response Relationship, Drug; Gene Expression Profiling; Gold / chemistry; Gold / metabolism; Gold / toxicity; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / metabolism; Reactive Oxygen Species / metabolism; Transcriptome / drug effects
TL;DR: Human hepatic uptake of 40 and 80 nm AuNP with branched polyethylenimine (BPEI), lipoic acid (LA) and polyethylene glycol (PEG) coatings as well as human plasma protein (HP) and human serum albumin (HSA) coronas was investigated to better understanding of the dramatic effect of protein coronas (PC) on AuNP cellular uptake, cytotoxicity and their underlying molecular mechanisms of action. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 27, 2021

2016 journal article

Protocol for diversion of confirmed positive bulk raw milk tankers to calf ranches – A review of the Pharmacokinetics of tetracyclines and sulfonamides in veal calves

Animal Health Research Reviews, 17(2), 127–136.

By: K. DeDonder*, R. Gehring*, L. Tell* & J. Riviere*

author keywords: tetracycline; chlortetracycline; oxytetracycline; sulfonamide; veal; residue; discard milk
MeSH headings : Animals; Anti-Bacterial Agents; Cattle / metabolism; Drug Residues; Milk / chemistry; Sulfonamides / pharmacokinetics; Tetracyclines / chemistry; Tetracyclines / pharmacokinetics
TL;DR: The suggested withdrawal interval of 20 days will ensure that no veal calves will test positive for residues from being fed this milk, and will provide a residue avoidance strategy for TTC and sulfonamide residues in veal. (via Semantic Scholar)
Source: Crossref
Added: October 1, 2021

2016 journal article

Quantification of nanoparticle pesticide adsorption: computational approaches based on experimental data

Nanotoxicology, 10(8), 1118–1128.

By: R. Chen*, Y. Zhang*, N. Monteiro-Riviere* & J. Riviere*

Contributors: R. Chen*, Y. Zhang*, N. Monteiro-Riviere* & J. Riviere*

author keywords: BSAI; in situ characterization; nanoparticles; pesticide; surface physicochemistry
MeSH headings : Adsorption; Models, Theoretical; Nanoparticles / analysis; Nanoparticles / chemistry; Neural Networks, Computer; Pesticides / analysis; Pesticides / chemistry; Principal Component Analysis; Surface Properties
TL;DR: The first attempt of the application of such quantitative measures toward environmental endpoints by analyzing the interactions of a selected group of nanomaterials with a variety of pesticides was made and quantitative computational approaches support theApplication of BSAI modeling in the area of environmental contamINANt detection and remediation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021

2016 journal article

Residue concerns following exposure to livestock to oil and petroleum products

Journal of the American Veterinary Medical Association, 248, 145–146.

By: K. DeDonder, R. Gehring, J. Riviere, R. Baynes, L. Tell & T. Vickroy

Source: NC State University Libraries
Added: February 5, 2022

2016 journal article

Screening and Confirmatory Analyses of Flunixin in Tissues and Bodily Fluids after Intravenous or Intramuscular Administration to Cull Dairy Cows with or without Lipopolysaccharide Challenge

Journal of Agricultural and Food Chemistry, 64(1), 336–345.

By: W. Shelver*, D. Smith*, L. Tell*, R. Baynes n, J. Schroeder* & J. Riviere*

author keywords: flunixin; ELISA; route of administration; concentration; food safety
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Cattle Diseases / blood; Cattle Diseases / drug therapy; Cattle Diseases / metabolism; Cattle Diseases / urine; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Drug Residues / pharmacokinetics; Female; Injections, Intramuscular; Kidney / chemistry; Kidney / metabolism; Liver / chemistry; Liver / metabolism; Milk / chemistry; Muscles / chemistry; Muscles / metabolism; Tissue Distribution
TL;DR: The ratio of urinary flunixin and 5-hydroxy flunxin may be useful for predicting disruption of metabolism caused by disease or other factors potentially leading to violative liver and milk violative residues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018

2016 chapter

The effects of vehicle mixtures on transdermal absorption: thermodynamics, mechanism, assessment and prediction

In N. Dragicevic-Curic & H. I. Maibach (Eds.), Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin: Methodology and General Considerations (pp. 95–118). New York: Springer.

By: J. Chittenden & J. Riviere

Ed(s): N. Dragicevic-Curic & H. Maibach

Source: NC State University Libraries
Added: February 5, 2022

2016 journal article

Toxicological effects of pet food ingredients on canine bone marrow-derived mesenchymal stem cells and enterocyte-like cells

Journal of Applied Toxicology, 36(2), 189–198.

By: M. Ortega*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

Contributors: M. Ortega*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

author keywords: canine; bone marrow stem cells; enterocyte like cells; adult stem cell differentiation; essential oils; cytotoxicity; mesenchymal stem cells; in vitro
MeSH headings : Acrolein / analogs & derivatives; Acrolein / toxicity; Animal Feed / toxicity; Animals; Bone Marrow / drug effects; Citric Acid / toxicity; Clove Oil / toxicity; Cytotoxins / toxicity; Dogs; Enterocytes / drug effects; Eugenol / toxicity; Ginger / toxicity; Guanosine Monophosphate / toxicity; Inosine Monophosphate / toxicity; Mesenchymal Stem Cells / drug effects; Oils, Volatile / toxicity; Pets; Plant Oils / toxicity; Plant Roots / toxicity; Sorbose / toxicity; Thymol / toxicity
TL;DR: These studies provide a baseline against which differential toxicity of dietary feed ingredients can be assessed in vitro for direct effects on canine cells and demonstrate differential toxicity in differentiated cells that represent gastrointestinal epithelial cells. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021

2015 journal article

A Framework for Meta-Analysis of Veterinary Drug Pharmacokinetic Data Using Mixed Effect Modeling

Journal of Pharmaceutical Sciences, 104(4), 1230–1239.

By: M. Li*, R. Gehring*, Z. Lin* & J. Riviere*

author keywords: meta-analysis; nonlinear mixed-effect modeling; pharmacokinetics; population pharmacokinetics; veterinary medicine; drug depletion; drug withdrawal time; clearance; distribution; formulation
MeSH headings : Animals; Computer Simulation; Data Mining; Databases, Factual; Humans; Meta-Analysis as Topic; Models, Biological; Models, Statistical; Nonlinear Dynamics; Reproducibility of Results; Species Specificity; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: The overriding strength of meta-analysis applied to this field is that robust statistical analysis of the diverse sparse data sets inherent to veterinary medicine applications can be accomplished, thereby allowing population inferences to be made. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: Crossref
Added: December 24, 2021

2015 journal article

Canine renal proximal tubule cells as an in vitro model for toxicity assessment of pet food ingredients

The Toxicologist, 144, 490.

By: J. Koci, B. Jeffery, J. Riviere & N. Monteiro-Riviere

Source: NC State University Libraries
Added: February 5, 2022

2015 journal article

Comparative In Vitro Cytotoxicity of 20 Potential Food Ingredients in Canine Liver, Kidney, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells

Applied In Vitro Toxicology, 1(4), 276–288.

By: N. Monteiro-Riviere*, M. Ortega*, K. Choi*, J. Koci*, Z. Lin*, B. Jeffery, J. Riviere*

TL;DR: Dose–response cytotoxicity studies and LC50 using alamar blue assays are reported for seven additional compounds: denatonium benzoate, eucalyptol, hexahydro isohumulone, tetrahydroisohumULone, green tea catechin extract, epigallocatechin gallate, and sodium copper chlorophyllin. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: April 30, 2021

2015 journal article

Comparison of pharmacokinetics and milk elimination of flunixin in healthy cows and cows with mastitis

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 246(1), 118–125.

By: L. Kissell n, T. Leavens n, R. Baynes n, J. Riviere n & G. Smith n

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Cephalosporins / therapeutic use; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Female; Mastitis, Bovine / drug therapy; Mastitis, Bovine / metabolism; Milk / chemistry
TL;DR: Pharmacokinetics and elimination of flunixin and 5-hydroxy flunxin in milk differed between mastitic and healthy cows, resulting in violative residues, which may partially explain the high number of fl unixin residues reported in beef and dairy cattle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Determination of thermodynamic solubility of active pharmaceutical ingredients for veterinary species: a new USP general chapter

Pharmacopeial Forum, 41(3).

By: M. Apley, G. Crist, V. Fellner, M. Gonzalez, R. Hunter, M. Martinez, J. Messenheimer, S. Modric ...

Source: NC State University Libraries
Added: February 5, 2022

2015 journal article

Development and Application of a Multiroute Physiologically Based Pharmacokinetic Model for Oxytetracycline in Dogs and Humans

Journal of Pharmaceutical Sciences, 104(1), 233–243.

By: Z. Lin*, M. Li*, R. Gehring* & J. Riviere*

author keywords: oxytetracycline; physiologically based pharmacokinetic (PBPK) modeling; dogs; tetracycline antibiotics; Food Animal Residue Avoidance Databank (FARAD); computational ADME; mathematical model; pharmacokinetics; in silico modeling; disposition
MeSH headings : Administration, Oral; Animals; Animals, Inbred Strains; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Computational Biology; Computer Simulation; Databases, Pharmaceutical; Dogs; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular; Injections, Intravenous; Kidney / metabolism; Models, Biological; Oxytetracycline / administration & dosage; Oxytetracycline / blood; Oxytetracycline / metabolism; Oxytetracycline / pharmacokinetics; Pharmacology, Clinical / methods; Physiology, Comparative / methods; Renal Elimination; Reproducibility of Results; Species Specificity; Tissue Distribution; Veterinary Medicine / methods
TL;DR: A permeability-limited multiroute physiologically based pharmacokinetic model developed in dogs can be used to predict plasma and tissue concentrations to aid in designing optimal therapeutic regimens with OTC in veterinary, and potentially, human medicine; and as a foundation for scaling to other tetracycline antibiotics and to other animal species. (via Semantic Scholar)
Source: Crossref
Added: October 1, 2021

2015 conference paper

Development of a physiologically-relevant multivariate nanoparticle molecular interaction fingerprint

Presented at the 250th American Chemical Society National Meeting, Boston, MA.

By: J. Riviere

Event: 250th American Chemical Society National Meeting at Boston, MA

Source: NC State University Libraries
Added: February 5, 2022

2015 journal article

Differential effects of some natural compounds on the transdermal absorption and penetration of caffeine and salicylic acid

International Journal of Pharmaceutics, 483(1-2), 151–157.

By: F. Muhammad* & J. Riviere*

author keywords: Natural substance; Skin; Penetration; Drugs
MeSH headings : Animals; Biological Products / chemistry; Biological Products / pharmacology; Caffeine / chemistry; Caffeine / pharmacokinetics; Carbon Radioisotopes; Diffusion; Dose-Response Relationship, Drug; Female; Molecular Structure; Permeability / drug effects; Salicylic Acid / chemistry; Salicylic Acid / pharmacokinetics; Skin Absorption / drug effects; Structure-Activity Relationship; Swine
TL;DR: The results emphasize the differential effects of natural substances on the transdermal penetration of hydrophilic (caffeine) and hydrophobic (salicylic acid) drugs. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 24, 2021

2015 journal article

Egg residue considerations during the treatment of backyard poultry

Journal of the American Veterinary Medical Association, 247(12), 1388–1395.

By: T. Marmulak, L. Tell, R. Gehring, R. Baynes*, T. Vickroy & J. Riviere*

MeSH headings : Animal Feed; Animal Husbandry; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Chickens; Drug Residues; Eggs / analysis; Poultry Diseases / drug therapy; Turkeys; United States; United States Food and Drug Administration
TL;DR: The purpose of this digest was to provide US veterinarians guidance on the responsible treatment of backyard poultry flocks and information regarding the depletion of drug residues in eggs from hens treated with various drugs in an extralabel manner is sparse or lacking. (via Semantic Scholar)
Sources: Crossref, Web Of Science
Added: August 6, 2018

2015 journal article

Estimation of residue depletion of cyadox and its marker residue in edible tissues of pigs using physiologically based pharmacokinetic modeling

Food Additives & Contaminants: Part A, 32(12), 2002–2017.

By: L. Huang*, Z. Lin*, X. Zhou*, M. Zhu*, R. Gehring*, J. Riviere*, Z. Yuan*

author keywords: cyadox; 1,4-bisdesoxycyadox; PBPK modelling; tissue depletion; residue prediction; sensitivity analysis; Monte Carlo analysis
MeSH headings : Adipose Tissue / chemistry; Adipose Tissue / metabolism; Animal Feed / analysis; Animals; Anti-Infective Agents / isolation & purification; Anti-Infective Agents / metabolism; Anti-Infective Agents / pharmacokinetics; Biotransformation; Chromatography, Liquid; Drug Residues / isolation & purification; Drug Residues / metabolism; Food Analysis / methods; Kidney / chemistry; Kidney / metabolism; Liver / chemistry; Liver / metabolism; Models, Statistical; Monte Carlo Method; Muscle, Skeletal / chemistry; Muscle, Skeletal / metabolism; Quinoxalines / isolation & purification; Quinoxalines / metabolism; Quinoxalines / pharmacokinetics; Swine; Tandem Mass Spectrometry; Veterinary Drugs / isolation & purification; Veterinary Drugs / metabolism; Veterinary Drugs / pharmacokinetics
TL;DR: A PBPK model was developed to simultaneously describe the depletion in pigs of the food animal antimicrobial agent cyadox, and its marker residue 1,4-bisdesoxycyadox (BDCYA). (via Semantic Scholar)
Source: Web Of Science
Added: February 5, 2022

2015 journal article

Excretory, Secretory, and Tissue Residues after Label and Extra-label Administration of Flunixin Meglumine to Saline- or Lipopolysaccharide-Exposed Dairy Cows

Journal of Agricultural and Food Chemistry, 63(19), 4893–4901.

By: D. Smith*, W. Shelver*, R. Baynes n, L. Tell*, R. Gehring*, M. Li*, T. Dutko, J. Schroeder*, G. Herges*, J. Riviere*

author keywords: dairy; extra-label; flunixin; holstein; liver; metabolite ratio; milk; residue
MeSH headings : Adipose Tissue / chemistry; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / analysis; Clonixin / pharmacokinetics; Drug Labeling; Drug Residues / analysis; Drug Residues / pharmacokinetics; Female; Inflammation / chemically induced; Inflammation / drug therapy; Kidney / chemistry; Lipopolysaccharides / adverse effects; Liver / chemistry; Milk / chemistry; Muscle, Skeletal / chemistry; Sodium Chloride / administration & dosage; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: Flunixin meglumine administered by either intravenous infusion or intramuscular injection at 24 h intervals may be related to LPS inhibition of flunixIn metabolism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science
Added: August 6, 2018

2015 conference paper

Flunixin urine residues in culled dairy cows and its relevance to food safety and environmental concern

Presented at the 250th American Chemical Society National Meeting, Boston, MA.

By: W. Shelver, D. Smith, L. Tell, R. Baynes, J. Schroeder & J. Riviere

Event: 250th American Chemical Society National Meeting at Boston, MA

Source: NC State University Libraries
Added: February 5, 2022

2015 journal article

Gold and silver nanoparticle interactions with human proteins: impact and implications in biocorona formation

Journal of Materials Chemistry B, 3(10), 2075–2082.

By: A. Sasidharan*, J. Riviere* & N. Monteiro-Riviere*

Contributors: A. Sasidharan*, J. Riviere* & N. Monteiro-Riviere*

TL;DR: Findings suggest that irrespective of NP surface chemistry or chemical composition, corona proteins at their physiological concentrations interact rather differently; wherein HSA and IgG coronas adsorbed strongly on the NP surface and kept both Au and AgNP well dispersed, while fibrinogen caused rapid, strong and irreversible agglomeration. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID, NC State University Libraries
Added: May 3, 2021

2015 journal article

In vitro safety assessment of food ingredients in canine renal proximal tubule cells

Toxicology in Vitro, 29(2), 289–298.

By: J. Koči*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

Contributors: J. Koči*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

author keywords: Food ingredients; Canine; Proximal tubule cells; Lemongrass oil; Gene expression; Metabolic pathway
MeSH headings : Acrolein / analogs & derivatives; Acrolein / toxicity; Aminophenols / toxicity; Animals; Cell Survival / drug effects; Citric Acid / toxicity; Dogs; Eugenol / toxicity; Food Safety; Gene Expression Profiling; Ginger; Guanosine Monophosphate / toxicity; Humans; Inosine Monophosphate / toxicity; Kidney Tubules, Proximal / cytology; Oils, Volatile / toxicity; Plant Extracts / toxicity; Plant Oils / toxicity; Plant Roots; Sorbose / toxicity; Terpenes / toxicity; Thymol / toxicity; Thymus Plant; Toxicity Tests / methods; Xylitol / toxicity
TL;DR: Viability assays along with mechanistic studies in the CPTC model may serve as a valuable in vitro toxicity screening tool. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 3, 2021

2015 journal article

Interaction of silver and gold nanoparticles with protein biocorona formation and its impact on cellular toxicity

International Journal of Toxicology, 34, 78–79.

By: N. Monteiro-Riviere, A. Sasidharan, R. Chen & J. Riviere

Source: NC State University Libraries
Added: February 5, 2022

2015 journal article

Nanoparticle surface characterization and clustering through concentration-dependent surface adsorption modeling

The Toxicologist, 144, 66.

By: R. Chen, Y. Zhang, F. Sahneh, C. Scoglio, W. Wohlleben, A. Haase, N. Monteiro-Riviere, J. Riviere

Source: NC State University Libraries
Added: February 5, 2022

2015 journal article

Pharmacokinetics and pharmacodynamics of gamithromycin in pulmonary epithelial lining fluid in naturally occurring bovine respiratory disease in multisource commingled feedlot cattle

Journal of Veterinary Pharmacology and Therapeutics, 39(2), 157–166.

By: K. DeDonder*, M. Apley*, M. Li*, R. Gehring*, D. Harhay*, B. Lubbers*, B. White*, S. Capik* ...

MeSH headings : Animals; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Area Under Curve; Body Fluids / chemistry; Body Fluids / metabolism; Bovine Respiratory Disease Complex / drug therapy; Bovine Respiratory Disease Complex / metabolism; Cattle; Epithelium / chemistry; Epithelium / metabolism; Lung; Macrolides / metabolism; Macrolides / pharmacokinetics; Macrolides / therapeutic use; Microbial Sensitivity Tests; Models, Biological
TL;DR: Findings indicate that higher PK/PD indices were predictive of positive treatment outcomes in feeder cattle diagnosed with bovine respiratory disease and treated with gamithromycin at the label dose. (via Semantic Scholar)
Sources: Crossref, Web Of Science
Added: October 2, 2021

2015 journal article

Pharmacokinetics of metallic nanoparticles

WIREs Nanomedicine and Nanobiotechnology, 7(2), 189–217.

Contributors: Z. Lin*, N. Monteiro-Riviere* & J. Riviere*

MeSH headings : Animals; Humans; Metal Nanoparticles / chemistry; Models, Biological; Pharmacokinetics
TL;DR: Physiologically based pharmacokinetic models for gold/dendrimer composite nanodevices, AgNPs, and TiO2 NP models have been developed in rats and extrapolated to humans to support risk assessment and nanomedicine applications. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021

2015 journal article

Predicting Adsorption Affinities of Small Molecules on Carbon Nanotubes Using Molecular Dynamics Simulation

ACS Nano, 9(12), 11761–11774.

author keywords: nanoparticles; free-energy calculations; surface physicochemistry; virtual screening; benzene derivatives; graphene; surface functionalization; aromatic
TL;DR: The authors' simulations suggest that polyvinylpyrrolidone conjugation gives the highest affinity for atrazine-substantially greater than that of graphenic carbon alone-and may be useful as a nanomaterial for delivery or sequestration of atrazin. (via Semantic Scholar)
Source: Crossref
Added: December 24, 2021

2015 journal article

Predicting the impact of biocorona formation kinetics on interspecies extrapolations of nanoparticle biodistribution modeling

Nanomedicine, 10(1), 25–33.

Contributors: F. Sahneh*, C. Scoglio*, N. Monteiro-Riviere* & J. Riviere*

author keywords: allometry; biocorona; interspecies extrapolation; in vitro-in vivo correlation; nanomaterials; nanoparticle biodistribution
MeSH headings : Animals; Humans; Kinetics; Mice; Models, Theoretical; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Pharmacokinetics; Rats; Surface Properties; Tissue Distribution
TL;DR: While engineered NPs can successfully reach target cells in rodent models, the results may be different in humans due to the fact that the longer circulation time allows for further biocorona evolution. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021

2015 journal article

Prediction and comparison of size-dependent biodistribution of polyethylene glycol-coated gold nanoparticles in adult mice: a physiologically based pharmacokinetic model

The Toxicologist, 144, 65.

By: Z. Lin, N. Monteiro-Riviere & J. Riviere

Source: NC State University Libraries
Added: February 5, 2022

2015 journal article

Quantification of vehicle mixture effects on in vitro transdermal chemical flux using a random process diffusion model

Journal of Controlled Release, 217, 74–81.

By: J. Chittenden n & J. Riviere*

author keywords: Transdermal absorption; Chemical mixture; QSPR; Skin permeability; Mathematical modeling; In vitro model
MeSH headings : 1-Octanol / chemistry; Animals; Diffusion; Models, Biological; Molecular Weight; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / metabolism; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption; Swine; Water / chemistry
TL;DR: This analysis improved on previous work, finding a more parsimonious model with higher predictability, while still identifying the mixture refractive index as a key descriptor in predicting vehicle effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science
Added: August 6, 2018

2015 journal article

Safety assessment of pet food ingredients using cryopreserved canine hepatocytes-based in vitro assays

The Toxicologist, 144, 20.

By: K. Choi, J. Riviere & N. Monteiro-Riviere

Source: NC State University Libraries
Added: February 5, 2022

2015 journal article

Safety assessment of potential food ingredients in canine hepatocytes

Food and Chemical Toxicology, 78, 105–115.

By: L. Zhang*, J. Koci*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

Contributors: L. Zhang*, J. Koci*, B. Jeffery, J. Riviere* & N. Monteiro-Riviere*

MeSH headings : Acetaminophen / toxicity; Acrolein / analogs & derivatives; Acrolein / toxicity; Aflatoxin B1 / toxicity; Animal Feed / standards; Animals; Cell Line; Cell Survival / drug effects; Dogs; Down-Regulation; Eugenol / toxicity; Food Analysis; Food Safety; Ginger / chemistry; Ginger / toxicity; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Lethal Dose 50; Oils, Volatile / toxicity; Plant Extracts / toxicity; Plant Oils / toxicity; Plant Roots / chemistry; Plant Roots / toxicity; Rats; Terpenes / toxicity; Thymol / toxicity; Up-Regulation; Xylitol / toxicity
TL;DR: In vitro assays such as this may be useful for hazard assessment of food ingredients for altered hepatic function, which CYP and heat shock most affected. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021

2015 journal article

Toxicokinetic approaches to improving accuracy of drug withdrawal times in food producing animals to avoid toxic violative tissue residues

International Journal of Toxicology, 34, 78.

By: J. Riviere, Z. Lin & M. Li

Source: NC State University Libraries
Added: February 5, 2022

2014 journal article

A pharmacokinetic modeling framework for interspecies extrapolation of nanoparticle biodistribution taking into account biocorona dynamics independent of species-specific disposition processes

Toxicologist, 138, 211.

By: J. Riviere, F. Sahneh, C. Scoglio & N. Monteiro-Riviere

Source: NC State University Libraries
Added: May 21, 2022

2014 journal article

Antimicrobial Agents in Veterinary Medicine

Journal of Veterinary Pharmacology and Therapeutics, 37(1), 1–1.

By: J. Riviere* & J. Fink-Gremmels

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacteria / drug effects; Bacterial Infections / drug therapy; Bacterial Infections / veterinary; Drug Resistance, Bacterial; Drug Utilization / standards
Source: Crossref
Added: December 24, 2021

2014 conference paper

Canine renal proximal tubule cells as an in vitro model for toxicity assessment of pet food ingredients

Central States Society of Toxicology Annual Meeting, 49.

By: J. Koci, B. Jeffery, J. Riviere & N. Monteiro-Riviere

Source: NC State University Libraries
Added: May 27, 2022

2014 chapter

Dermal Exposure and Absorption of Chemicals and Nanomaterials

In Reference Module in Biomedical Sciences.

By: J. Riviere* & N. Monteiro-Riviere*

Sources: Crossref, NC State University Libraries
Added: May 30, 2021

2014 chapter

Dermatoxicity of nanomaterials

In B. Fadeel (Ed.), Handbook of Safety Assessment of Nanomaterials: From Toxicology Testing to Personalized Medicine (pp. 439–459). Singapore: Pan Stanford.

By: N. Monteiro-Riviere & J. Riviere

Ed(s): B. Fadeel

Source: NC State University Libraries
Added: May 27, 2022

2014 journal article

Development of a Mixed-Effect Pharmacokinetic Model for Vehicle Modulated In Vitro Transdermal Flux of Topically Applied Penetrants

JOURNAL OF PHARMACEUTICAL SCIENCES, 103(3), 1002–1012.

By: J. Chittenden n, J. Brooks n & J. Riviere*

author keywords: transdermal drug delivery; skin; passive diffusion; transport; mathematical model; in vitro models; formulation vehicle; diffusion
MeSH headings : Administration, Cutaneous; Algorithms; Animals; Diffusion; Dimethylpolysiloxanes / chemistry; In Vitro Techniques; Models, Biological; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / analysis; Pharmaceutical Preparations / chemistry; Pharmaceutical Vehicles / chemistry; Pharmacokinetics; Reproducibility of Results; Skin Absorption; Sus scrofa
TL;DR: A mixed effects modeling framework was used so that models can be estimated with as few parameters as possible, while also quantifying variability and accounting for correlation in the data. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus)

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 31(9), 1506–1521.

By: T. Leavens n, L. Tell*, L. Kissell n, G. Smith n, D. Smith*, S. Wagner*, W. Shelver*, H. Wu n ...

author keywords: flunixin; PBPK models; withdrawal intervals; route of administration; cattle (Bos taurus)
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle / blood; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Drug Residues; Liver / chemistry; Liver / metabolism; Milk / chemistry; Models, Biological; Sensitivity and Specificity; Software; Uncertainty
TL;DR: A physiologically based pharmacokinetic (PBPK) model was developed to predict plasma, liver and milk concentrations of flunixin in cattle following intravenous, intramuscular or subcutaneous administration for use as a tool to determine factors that may affect the withdrawal time. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 conference paper

Differential effects of some natural compounds on the transdermal penetration of caffeine and salicylic acid

Central States Society of Toxicology Annual Meeting, 52.

By: F. Muhammad & J. Riviere

Source: NC State University Libraries
Added: May 27, 2022

2014 conference paper

Impact and implications of gold nanoparticle interactions with human serum proteins and biocorona formation

Central States Society of Toxicology Annual Meeting, 19.

By: S. Sasidharan, J. Riviere & N. Monteiro-Riviere

Source: NC State University Libraries
Added: May 27, 2022

2014 chapter

Importance of veterinary drug residues

In R. Baynes & J. E. Riviere (Eds.), Strategies for Reducing Drug and Chemical Residues in Food Animals: International Approaches to Residue Avoidance, Management and Testing (pp. 1–8,). New York: Wiley.

By: R. Baynes & J. Riviere

Ed(s): R. Baynes & J. Riviere

Source: NC State University Libraries
Added: May 21, 2022

2014 journal article

In silico models to predict dermal absorption from complex agrochemical formulations

SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 25(7), 565–588.

By: K. Guth n, J. Riviere n, J. Brooks n, M. Dammann*, E. Fabian*, B. Ravenzwaay*, M. Schaefer-Korting, R. Landsiedel*

author keywords: dermal absorption; mixture; quantitative structure permeability relationship (QSPR); risk assessment; agrochemicals
MeSH headings : Agrochemicals / pharmacokinetics; Animals; Complex Mixtures / pharmacokinetics; Computer Simulation; Humans; Linear Models; Models, Biological; Quantitative Structure-Activity Relationship; Rats; Skin / metabolism; Skin Absorption
TL;DR: Application of this in silico prediction model would reduce animal and non-animal testings when used for the optimization of formulations in early developmental stages, or would simplify the registration process, if accepted for read-across. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

In silico models to predict dermal absorption from complex agrochemical formulations

SAR and QSAR in Environmental Research, 6, 1–24.

By: K. Guth, J. Riviere, J. Brooks, M. Schaefer-Korting, M. Dammann, J. Fabian, B. Van Ravenzwaay, R. Landsiedal

Source: NC State University Libraries
Added: February 5, 2022

2014 journal article

In vitro safety assessment of pet food ingredients on canine primary renal tubule cell lines

Toxicologist, 138, 81.

By: J. Koci, B. Jeffery, J. Riviere & N. Monteiro-Riviere

Source: NC State University Libraries
Added: May 21, 2022

2014 journal article

Interspecies Mixed-Effect Pharmacokinetic Modeling of Penicillin G in Cattle and Swine

Antimicrobial Agents and Chemotherapy, 58(8), 4495–4503.

By: M. Li*, R. Gehring*, L. Tell*, R. Baynes n, Q. Huang* & J. Riviere*

MeSH headings : Age Factors; Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Body Weight; Cattle; Humans; Injections, Intramuscular; Injections, Intravenous; Kidney / chemistry; Kidney / metabolism; Liver / chemistry; Liver / metabolism; Meat / analysis; Models, Statistical; Muscle, Skeletal / chemistry; Muscle, Skeletal / metabolism; Penicillin G / blood; Penicillin G / pharmacokinetics; Species Specificity; Swine
TL;DR: This study established a robust model of penicillin for a large and diverse population of food-producing animals which could be applied to other antibiotics and species in future analyses. (via Semantic Scholar)
Sources: Crossref, Web Of Science
Added: August 6, 2018

2014 journal article

Interspecies allometric meta-analysis of the comparative pharmacokinetics of 85 drugs across veterinary and laboratory animal species

Journal of Veterinary Pharmacology and Therapeutics, 38(3), 214–226.

By: Q. Huang, R. Gehring, L. Tell, M. Li & J. Riviere n

Event: American Conference on Pharmacometrics at Las Vegas, NV

MeSH headings : Animals; Humans; Species Specificity; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: The results showed that 77% and 88% of drugs displayed significant correlations between total systemic clearance (CL) and volume of distribution at steady status (Vss) vs. body weight (P < 0.05) on a log-log scale, respectively. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 24, 2021

2014 conference paper

Interspecies and in vitro / in vivo extrapolation of nanoparticle biodistribution involving protein corona formation

Proceedings of the 7th International Nanotoxicology Conference, 31.

By: L. Riviere

Event: 7th International Nanotoxicology Conference at Antalya, Turkey

Source: NC State University Libraries
Added: May 21, 2022

2014 journal article

Nanoparticle Surface Characterization and Clustering through Concentration-Dependent Surface Adsorption Modeling

ACS Nano, 8(9), 9446–9456.

By: R. Chen, Y. Zhang, F. Darabi Sahneh, C. Scoglio, W. Wohlleben*, A. Haase*, N. Monteiro-Riviere*, J. Riviere*

Contributors: R. Chen, Y. Zhang, F. Darabi Sahneh, C. Scoglio, W. Wohlleben*, A. Haase*, N. Monteiro-Riviere*, J. Riviere*

author keywords: BSAI; nanoparticles; nanomedicine; nanotoxicology surface physicochemistry; in situ characterization
MeSH headings : Adsorption; Models, Molecular; Nanoparticles / chemistry; Surface Properties
TL;DR: The approach beyond the application of five descriptors in the original BSAI to address the concentration dependence of the descriptors, enabling better prediction of the adsorption profile and more accurate categorization of nanomaterials based on their surface properties is advanced. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: June 12, 2021

2014 conference paper

Nanoparticle surface characterization and clustering through concentration-dependent surface adsorption modeling

Central States Society of Toxicology Annual Meeting, 46.

By: R. Chen, Y. Zhang, F. Sahneh, C. Scoglio, W. Wohlleben, A. Haase, N. Monteiro-Riviere, J. Riviere

Source: NC State University Libraries
Added: May 27, 2022

2014 chapter

Pharmacokinetics and biodistribution of nanomaterials

In N. A. Monteiro-Riviere & C. L. Tran (Eds.), Nanotoxicology (2nd ed., pp. 135–152). New York: Informa.

By: J. Riviere

Ed(s): N. Monteiro-Riviere & C. Tran

Source: NC State University Libraries
Added: May 27, 2022

2014 conference paper

Pharmacokinetics and pharmacodynamics of gamithromycin in pulmonary epithelial lining fluid 9PLF) in naturally occurring bovine respiratory disease in multi-sourced commingled feedlot cattle

Presented at the 7th International Conference on Antimicrobial Agents in Veterinary Medicine, Berlin, Germany.

By: K. DeDonder, M. Apley, D. Harhaz, R. Gehring, B. Lubbers, B. KuKanich, J. Riviere, R. Tessnan

Event: 7th International Conference on Antimicrobial Agents in Veterinary Medicine at Berlin, Germany

Source: NC State University Libraries
Added: May 21, 2022

2014 journal article

Pharmacokinetics, tissue distribution, and excretion of nomegestrol acetate in female rats

European Journal of Drug Metabolism and Pharmacokinetics, 40(4), 435–442.

By: Q. Huang*, X. Chen, Y. Zhu*, L. Cao* & J. Riviere*

author keywords: Nomegestrol acetate; NOMAC; Pharmacokinetics; Tissue distribution; Excretion; HPLC
MeSH headings : Animals; Bile / drug effects; Bile / metabolism; Feces; Female; Liver / drug effects; Liver / metabolism; Megestrol / pharmacokinetics; Megestrol / urine; Norpregnadienes / pharmacokinetics; Norpregnadienes / urine; Rats; Rats, Sprague-Dawley; Tissue Distribution / drug effects; Tissue Distribution / physiology
TL;DR: NOMAC had a widespread distribution in tissues, including ovary, pituitary, and hypothalamus, which are main target tissues where NOMAC inhibits ovulation. (via Semantic Scholar)
Source: Crossref
Added: December 24, 2021

2014 chapter

Physiologically based nanomaterial pharmacokinetic (PBNK) models

In B. Fadeel (Ed.), Handbook of Safety Assessment of Nanomaterials: From Toxicology Testing to Personalized Medicine (pp. 243–264). Singapore: Pan Stanford.

By: J. Riviere

Ed(s): B. Fadeel

Source: NC State University Libraries
Added: May 27, 2022

2014 conference paper

Prediction and comparison of size-dependent biodistribution of polyethylene glycol-coated gold nanoparticles in adult mice: a physiologically based pharmacokinetic model

Central States Society of Toxicology Annual Meeting, 50.

By: Z. Lin, N. Monteiro-Riviere & J. Riviere

Source: NC State University Libraries
Added: May 27, 2022

2014 journal article

Prediction of formulation effects on dermal absorption of topically applied ectoparasiticides dosed in vitro on canine and porcine skin using a mixture-adjusted quantitative structure permeability relationship

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 37(5), 435–444.

By: J. Riviere n, J. Brooks n, W. Collard*, J. Deng*, G. Rose*, S. Mahabir*, D. Merritt*, A. Marchiondo*

MeSH headings : Administration, Topical; Animals; Chemical Phenomena; Dogs; Insecticides / pharmacokinetics; Models, Biological; Permeability; Skin / drug effects; Skin Absorption / physiology; Swine; Tissue Culture Techniques
TL;DR: These studies clearly showed that the permeation of topical ectoparasiticides could be well predicted using QSPeR models that account for both the physical-chemical properties of the penetrant and formulation components. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 chapter

Risk management of chemical contaminants in livestock

In R. Baynes & J. E. Riviere (Eds.), Strategies for Reducing Drug and Chemical Residues in Food Animals: International Approaches to Residue Avoidance, Management and Testing (pp. 303–312). New York: Wiley.

By: J. Baynes & J. Riviere

Ed(s): R. Baynes & J. Riviere

Source: NC State University Libraries
Added: May 21, 2022

2014 conference paper

Safety assessment of pet food ingredients using cryopreserved canine hepatocytes-based in vitro assays

Central States Society of Toxicology, 47.

By: K. Choi, B. Jeffery, J. Riviere & N. Monteiro-Riviere

Event: Central States Society of Toxicology

Source: NC State University Libraries
Added: May 21, 2022

2014 journal article

Safety assessment of potential food ingredients on canine primary hepatocytes

Toxicologist, 138, 420.

By: L. Zhang, B. Jeffery, J. Riviere & N. Monteiro-Riviere

Source: NC State University Libraries
Added: May 21, 2022

2014 conference paper

Silver and gold metal nanoparticle-protein interactions: Role of physiochemical properties

Proceedings of the 7th International Nanotoxicology Conference, 245–246.

By: N. Monteiro-Riviere, A. Sasidharan, R. Chen & J. Riviere

Event: 7th International Nanotoxicology Conference at Antalya, Turkey

Source: NC State University Libraries
Added: May 21, 2022

2014 chapter

The Food Animal Residue Avoidance databank: An example of risk management of veterinary drug residues

In R. Baynes & J. E. Riviere (Eds.), Strategies for Reducing Drug and Chemical Residues in Food Animals: International Approaches to Residue Avoidance, Management and Testing (pp. 289–302). New York: Wiley.

By: T. Vickroy, R. Baynes, L. Tell & J. Riviere

Ed(s): R. Baynes & J. Riviere

Source: NC State University Libraries
Added: May 21, 2022

2014 journal article

The application of allometric scaling principles to predict pharmacokinetic parameters across species

Expert Opinion on Drug Metabolism & Toxicology, 10(9), 1241–1253.

By: Q. Huang & J. Riviere*

author keywords: allometric scaling; clearance; comparative pharmacology; elimination half-life; interspecies pharmacokinetics; veterinary medicine; volume of distribution
MeSH headings : Animals; Dose-Response Relationship, Drug; Humans; Models, Theoretical; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Pharmacokinetics; Species Specificity; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR: Although interspecies allometric scaling needs further refinements and has limitations, it is still a potential tool and rational option for the estimate of pharmacokinetic parameters in species for which there are no data available or to better interpret preclinical efficacy and safety trials. (via Semantic Scholar)
Source: Crossref
Added: December 24, 2021

2014 conference paper

Toxicological effect of a pet food ingredient on canine bone marrow derived mesenchymal stem cells and enterocyte-like cells

Central States Society of Toxicology Annual Meeting, 53.

By: M. Ortega, B. Jeffery, J. Riviere & N. Monteiro-Riviere

Source: NC State University Libraries
Added: May 27, 2022

2014 journal article

Understanding the dynamic behavior of the protein corona and its influence on the physiochemical composition of silver nanoparticles

Toxicologist, 138, 211.

By: A. Sasidharan, R. Chen, J. Riviere & N. Monteiro-Riviere

Source: NC State University Libraries
Added: May 21, 2022

2013 journal article

A dynamically integrative PKPD model to predict the efficacy of marbofloxacin treatment regimen for bovine Manheima hemolytica infection

PAGE, 22, 153,

By: R. Gehring, M. Apley & J. Riviere

Source: NC State University Libraries
Added: July 29, 2022

2013 journal article

Animal Health Modeling and Simulation Society (AHM&S): A new society promoting model-based approaches for a better integration and understanding of quantitative pharmacology in veterinary science

PAGE, 22, 143,

By: M. Fink, J. Mochel, J. Gabrielsson, W. Collard, R. Gehring, C. Laffont-Rouset, Y. Liu, T. Martin-Jimenez ...

Source: NC State University Libraries
Added: June 17, 2022

2013 journal article

Animal Health Modeling and Simulation Society (AHM&S): A new society promoting model-based approaches in veterinary pharmacology

Journal of Veterinary Pharmacology and Therapeutics, 36, 417–419.

By: J. Mochel, J. Gabrielsson, W. Collard, M. Fink, R. Gehring, C. Laffont, Y. Liu, T. Martin-Jimenez ...

Source: NC State University Libraries
Added: May 27, 2022

2013 journal article

Assessing vehicle effects on skin absorption of non-volatile compounds using membrane-coated fiber arrays

Cutaneous and Ocular Toxicology, 32(4), 283–289.

By: D. Karadzovska n & J. Riviere*

author keywords: Absorption; chemical mixtures; membrane-coated fiber; skin
MeSH headings : Acrylic Resins / chemistry; Caffeine / chemistry; Cortisone / chemistry; Diclofenac / chemistry; Dimethylpolysiloxanes / chemistry; Ethanol / chemistry; Mannitol / chemistry; Membranes, Artificial; Polyethylene Glycols / chemistry; Salicylic Acid / chemistry; Skin Absorption; Testosterone / chemistry; Volatilization; Water / chemistry
TL;DR: The MCF array is not suitable to describe the vehicle effects on skin absorption of non-volatile compounds, and its potential use as a formulation screening technique is disputes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: December 24, 2021

2013 journal article

Assessing vehicle effects on skin absorption using artificial membrane assays

European Journal of Pharmaceutical Sciences, 50(5), 569–576.

By: D. Karadzovska n & J. Riviere*

author keywords: Skin; Parallel artificial membrane permeability assays (PAMPAS); Isopropyl myristate; Certramides; Strat-M (TM); Dermal/percutaneous absorption
MeSH headings : Animals; Biological Assay; Caffeine / chemistry; Caffeine / metabolism; Cortisone / chemistry; Cortisone / metabolism; Diclofenac / chemistry; Diclofenac / metabolism; Ethanol / chemistry; In Vitro Techniques; Mannitol / chemistry; Mannitol / metabolism; Membranes, Artificial; Propylene Glycol / chemistry; Quantitative Structure-Activity Relationship; Salicylic Acid / chemistry; Salicylic Acid / metabolism; Skin / metabolism; Skin Absorption; Swine; Testosterone / chemistry; Testosterone / metabolism; Water / chemistry
TL;DR: Three artificial membranes were evaluated for their ability to predict the skin permeability of caffeine, cortisone, diclofenac sodium, mannitol, salicylic acid and testosterone applied in propylene glycol, water and ethanol as unsaturated and saturated concentrations and identified different physicochemical factors influencing the absorption process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Crossref
Added: December 24, 2021

2013 conference paper

Assessment of drug-vehicle interactions seen in topical delivery using three PAMPA artificial membrane systems.

Riviere, J. E., & Karadzovska, D. (2013, July 21). Presented at the 40th Annual Meeting & Exposition of the Controlled Release Society.

By: J. Riviere & D. Karadzovska

Event: 40th Annual Meeting & Exposition of the Controlled Release Society on July 21-24, 2013

Source: NC State University Libraries
Added: June 17, 2022

2013 journal article

Biological Surface Adsorption Index (BSAI): A molecular signature for nanomaterial interactions

Toxicologist, 132, 517.

By: J. Riviere

Source: NC State University Libraries
Added: May 27, 2022

2013 conference paper

Comparison of ELISA and LC MS/MS for the measurement of flunixin plasma concentration in beef cattle after intravenous and subcutaneous administration

Shelver, W. L., Tell, L. A., Wagner, S., Wetzlich, S. E., Baynes, R. E., & Riviere, J. E. (2013, August 25). Presented at the 127th AOAC Annual Meeting & Exposition, Chicago, IL.

By: W. Shelver, L. Tell, S. Wagner, S. Wetzlich, R. Baynes & J. Riviere

Event: 127th AOAC Annual Meeting & Exposition at Chicago, IL on August 25-28, 2013

Source: NC State University Libraries
Added: June 17, 2022

2013 journal article

Comparison of ELISA and LC-MS/MS for the Measurement of Flunixin Plasma Concentrations in Beef Cattle after Intravenous and Subcutaneous Administration

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61(11), 2679–2686.

By: W. Shelver*, L. Tell*, S. Wagner*, S. Wetzlich*, R. Baynes n, J. Riviere n, D. Smith*

author keywords: cattle; flunixin; ELISA; pharmacokinetics; elimination; administration; concentration
MeSH headings : Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Cattle; Chromatography, High Pressure Liquid / methods; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / blood; Enzyme-Linked Immunosorbent Assay / methods; Injections, Intravenous; Tandem Mass Spectrometry / methods; Veterinary Drugs / administration & dosage; Veterinary Drugs / blood
TL;DR: Quantitative immunoassay was a satisfactory method of flunixin analysis and it would be difficult to differentiate routes of administration in healthy beef cattle based on the plasma elimination profile of fl unixin after IV or SC administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 conference paper

Comparison of flunixin pharmacokinetic and milk elimination in healthy cows and cows with mastitis

Proceedings of the 18th American Academy of Veterinary Pharmacology and Therapeutics Biennial Symposium. Presented at the 18th American Academy of Veterinary Pharmacology and Therapeutics Biennial Symposium, Potomac, MD.

By: L. Kissel, G. Smith, T. Leavens, R. Baynes & J. Riviere

Event: 18th American Academy of Veterinary Pharmacology and Therapeutics Biennial Symposium at Potomac, MD

Source: NC State University Libraries
Added: May 27, 2022

2013 journal article

Computational approaches and metrics needed for formulating biologically realistic nanomaterial pharmacokinetic models

Computational Science & Discovery, 6(1).

By: J. Riviere*, C. Scoglio, F. Sahneh & N. Monteiro-Riviere

Source: NC State University Libraries
Added: June 3, 2022

2013 report

Developing a global curriculum for regulators

[Discussion Paper]. https://nam.edu/wp-content/uploads/2015/06/BGH-GlobalCurriculum.pdf

By: C. Preston, S. Azatyans, T. Bell, K. Bond, J. Bradsher, M. Brumfield, G. Buckely, T. Hughes ...

Source: NC State University Libraries
Added: June 3, 2022

2013 journal article

Dynamics of nanoparticle-protein corona complex. Analytical results from population balance equations

PlosOne, 8, 64690.

By: F. Sahneh*, C. Scoglio* & J. Riviere*

MeSH headings : Humans; Kinetics; Models, Statistical; Nanoparticles / chemistry; Nonlinear Dynamics; Particle Size; Protein Binding; Proteins / chemistry; Surface Properties
TL;DR: The dynamics of biocorona formation constitute vital aspect of interactions between nanoparticles and living organisms, and modeling results for in vitro systems to better predict behavior for in vivo systems are modeled. (via Semantic Scholar)
Source: Web Of Science
Added: May 27, 2022

2013 journal article

FARAD Digest: Effects of new sampling protocols on procaine penicillin G withdrawal intervals for cattle

Journal of the American Veterinary Medical Association, 243(10), 1408–1412,

By: K. DeDonder, R. Gehring, R. Baynes, L. Tell, T. Vickroy, M. Apley, J. Riviere

Source: NC State University Libraries
Added: June 3, 2022

2013 conference paper

Food Safety: The interaction of pharmacometrics and veterinary medicine

Population Approach Group in Europe (PAGE) 2013 meeting, 20–21.

By: J. Riviere

Source: NC State University Libraries
Added: May 27, 2022

2013 conference paper

Impact of nanoparticle protein corona on assessing in vitro cellular uptake of silver nanoparticles into human epidermal keratinocytes. 40th Annual Mtg

Monteiro-Riviere, N. A., Samberg, M., Oldenburg, S., & Riviere, J. E. (2013, July 21). Presented at the 40th Annual Meeting & Exposition of the Controlled Release Society, Honolulu, Hawaii.

By: N. Monteiro-Riviere, M. Samberg, S. Oldenburg & J. Riviere

Event: 40th Annual Meeting & Exposition of the Controlled Release Society at Honolulu, Hawaii on July 21-24, 2013

Source: NC State University Libraries
Added: June 17, 2022

2013 conference paper

In silico models for dermal absorption from complex formulations

Guth, K., Riviere, J., Brooks, J., Schafer-Korting, M., Dammann, M., Fabian, E., … Landsiedel, R. (2013, September). Presented at the 15th Congress of European Society for Alternatives to Animal Testing (EUSAAT), Linz, Austria.

By: K. Guth, J. Riviere, J. Brooks, M. Schafer-Korting, M. Dammann, E. Fabian, B. van Ravenzwaay, R. Landsiedel

Event: 15th Congress of European Society for Alternatives to Animal Testing (EUSAAT) at Linz, Austria

Source: NC State University Libraries
Added: May 27, 2022

2013 journal article

In silico models for dermal absorption from complex formulations

Naunyn-Schmiedelberg’s Archives of Pharmacology, 386, 29.

By: K. Guth, J. Riviere, J. Brooks, M. Schafer-Korting, M. Dammann, E. Fabian, B. Ravenzwaay, R. Landsiedel

Source: NC State University Libraries
Added: May 27, 2022

2013 journal article

Limitations of MIC as the sole criterion in antimicrobial drug dosage regimen design: The need for full characterization of antimicrobial pharmacodynamic profile especially for drug-resistant organisms

The Veterinary Journal, 198(1), 15–18.

By: R. Gehring* & J. Riviere*

MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / pharmacology; Bacteria / drug effects; Drug Resistance, Bacterial; Microbial Sensitivity Tests / methods; Microbial Sensitivity Tests / veterinary; Models, Biological
TL;DR: The conventional measure of a target pathogen’s sensitivity to an antimicrobial drug is the minimum concentration that will inhi-bit visible growth in vitro after overnight incubation (MIC), which is based on exposure of bacterial cultures to serial dilutions of anti-microbial concentrations. (via Semantic Scholar)
Source: Crossref
Added: December 24, 2021

2013 journal article

Modeling the effect of experimental variables on the in vitro permeation of six model compounds across porcine skin

International Journal of Pharmaceutics, 443(1-2), 58–67.

By: D. Karadzovska n, J. Brooks n & J. Riviere*

author keywords: Quantitative structure-permeability; relationships (QSPeRs); Experimental variables; Mixture factor; Steady-state flux; Percutaneous absorption
MeSH headings : Animals; Drug Carriers; Female; Hydrogen Bonding; In Vitro Techniques; Models, Biological; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Quantitative Structure-Activity Relationship; Regression Analysis; Skin / metabolism; Skin Absorption; Swine
TL;DR: Development and statistical validation of QSPeR models that incorporate the effects of penetrant, vehicle, and experimental conditions such as dose volume (finite/infinite), and saturation level (saturated/unsaturated). (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018

2013 conference paper

Nanomaterial pharmacokinetics and biodistribution: Can in vitro data quantitatively predict in vivo?

Riviere, J. E., & Monteiro-Riviere, N. A. (2013, October 28). Presented at the 6th International Symposium on Nanotechnology, Occupational and Environmental Health., Nagoya, Japan.

By: J. Riviere & N. Monteiro-Riviere

Event: 6th International Symposium on Nanotechnology, Occupational and Environmental Health. at Nagoya, Japan on October 28-31, 2013

Source: NC State University Libraries
Added: June 17, 2022

2013 journal article

Occurrence of flunixin residues in bovine milk samples from the USA

Food Additives & Contaminants: Part A, 30(9), 1513–1516.

By: L. Kissell n, R. Baynes n, J. Riviere* & G. Smith n

author keywords: flunixin; milk residues; UPLC-MS; CHARM((R)); milk; food safety
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Cattle; Chromatography, High Pressure Liquid; Clonixin / analogs & derivatives; Clonixin / analysis; Clonixin / metabolism; Dairying / legislation & jurisprudence; Drug Residues / analysis; Enzyme-Linked Immunosorbent Assay; Food Contamination / legislation & jurisprudence; Food Handling; Food Inspection / legislation & jurisprudence; Guideline Adherence; Legislation, Food; Milk / chemistry; Milk / standards; Spectrometry, Mass, Electrospray Ionization; Transportation; United States; United States Department of Agriculture; United States Food and Drug Administration
TL;DR: The results of this study indicate that flunixin residues in milk are possible, and regulatory agencies should be aware that such residues can occur, and should consider incorporating or expanding flunxin screening tests as part of routine drug monitoring in milk. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Of mice, men and nanoparticle biocoronas: are in vitro to in vivo correlations and interspecies extrapolations realistic?

Nanomedicine, 8(9), 1357–1359.

By: J. Riviere*

author keywords: biocorona; biodistribution; in vitro-in vivo correlation; interspecies extrapolation; nanoparticle; pharmacokinetics; protein corona
MeSH headings : Drug Delivery Systems; Humans; Lipids / administration & dosage; Lipids / chemistry; Nanoparticles / administration & dosage; Nanoparticles / chemistry; RNA, Small Interfering / administration & dosage; RNA, Small Interfering / chemistry
TL;DR: These issues have not been adequately considered by the nanomedicine or nanotoxicology commu­ nity, and are even ignored in current risk assess­ ment paradigms, yet are crucial for making biologically meaningful extrapolations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure (OpenAlex)
Source: Crossref
Added: December 24, 2021

2013 journal article

Oxidative Stress and Dermal Toxicity of Iron Oxide Nanoparticles In Vitro

CELL BIOCHEMISTRY AND BIOPHYSICS, 67(2), 461–476.

By: A. Murray*, E. Kisin*, A. Inman n, S. Young*, M. Muhammed*, T. Burks*, A. Uheida*, A. Tkach* ...

Contributors: A. Murray*, E. Kisin*, A. Inman n, S. Young*, M. Muhammed*, T. Burks*, A. Uheida*, A. Tkach* ...

author keywords: Nanoparticles; Skin exposure; Ultraviolet radiation; Iron oxide
MeSH headings : Biological Transport; Cell Survival / drug effects; Cytokines / metabolism; Glutathione / metabolism; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; L-Lactate Dehydrogenase / metabolism; Magnetite Nanoparticles / chemistry; Magnetite Nanoparticles / toxicity; NF-kappa B / metabolism; Oxidative Stress / drug effects; Particle Size; Skin / cytology; Skin / drug effects; Transcription Factor AP-1 / metabolism
TL;DR: Data indicate that co-exposure to UVB and SPIONs was associated with induction of oxidative stress and release of inflammatory mediators, verifying the need to thoroughly evaluate the adverse effects of UVB when evaluating dermal toxicity of engineered NPs on skin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 review

Predicting skin permeability from complex vehicles

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 65(2), 265–277.

By: D. Karadzovska n, J. Brooks n, N. Monteiro-Riviere n & J. Riviere n

Contributors: D. Karadzovska n, J. Brooks n, N. Monteiro-Riviere n & J. Riviere n

author keywords: Chemical mixtures; Formulations; Percutaneous/dermal absorption; Quantitative structure-permeation relationship (QSPR); QSAR; Linear free energy relationships (LFER); Mixture factor; Topical drug delivery enhancers
MeSH headings : Animals; Drug Delivery Systems; Humans; Linear Energy Transfer; Models, Theoretical; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Pharmaceutical Vehicles / chemistry; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption
TL;DR: This review highlights the progress made in predicting skin permeability from complex vehicles by extending the use of quantitative structure-permeation relationship (QSPR) models based on linear free energy relationships (LFER) to predict dermal absorption from complex mixtures with the inclusion of significant molecular descriptors such as a mixture factor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Prediction of flunixin tissue residue concentrations in livers from diseased cattle

Food and Chemical Toxicology, 62, 876–879.

By: H. Wu, R. Baynes*, L. Tell & J. Riviere*

author keywords: Flunixin; Population pharmacokinetics; Tissue residue; Monte Carlo simulation
TL;DR: The objective of this analysis was to explore how the changes in pharmacokinetic (PK) parameters that may be associated with diseased animals affect the predicted liver residue of flunixin in cattle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018

2013 journal article

Protein binding effects cellular uptake of silver nanoparticles in human cells

Toxicologist, 132, 283–284.

By: N. Monteiro-Riviere, A. Inman, M. Samburg, S. Oldenburg & J. Riviere

Source: NC State University Libraries
Added: May 27, 2022

2013 journal article

Protein binding modulates the cellular uptake of silver nanoparticles into human cells: Implications for in vitro to in vivo extrapolations?

TOXICOLOGY LETTERS, 220(3), 286–293.

By: N. Monteiro-Riviere n, M. Samberg n, S. Oldenburg* & J. Riviere n

Contributors: N. Monteiro-Riviere n, M. Samberg n, S. Oldenburg* & J. Riviere n

author keywords: Protein corona; Protein binding of nanoparticles; Cellular uptake of silver nanoparticles; Albumin cell uptake; Transferrin cell uptake; IgG cell uptake
MeSH headings : Humans; Immunoglobulin G / metabolism; Keratinocytes / metabolism; Metal Nanoparticles / chemistry; Microscopy, Electron, Transmission; Protein Binding; Serum Albumin / metabolism; Silver / metabolism; Transferrin / metabolism
TL;DR: NP association with different serum proteins, purportedly forming different protein coronas, significantly modulates Ag uptake into HEK compared to native NP uptake, suggesting caution in extrapolating in vitro uptake data to predict behavior in vivo where the nature of the protein corona may determine patterns of cellular uptake, and thus biodistribution, biological activity and toxicity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 conference paper

Protein corona effects silver nanoparticle uptake in human cells

Presented at the 4th Annual Nanofronteirs Symposium, Columbia, MO.

By: N. Monteiro-Riviere, M. Samberg, S. Oldenburg & J. Riviere

Event: 4th Annual Nanofronteirs Symposium at Columbia, MO

Source: NC State University Libraries
Added: June 17, 2022

2013 conference paper

Skin exposure to nanomaterials: Should we be concerned?

The 6th International Symposium on Nanotechnology, Occupational and Environmental Health, 48. Nagoya, Japan.

By: N. Monteiro-Riviere & J. Riviere

Source: NC State University Libraries
Added: May 27, 2022

2013 journal article

Solubility criteria for veterinary drugs: Workshop report

Pharm. Forum, 39(3).

By: M. Apley, B. Crist, M. Gonzalez, R. Hunter, M. Martinez, S. Modric, M. Papich, F. Parr, J. Riviere, M. Marques

Source: NC State University Libraries
Added: May 27, 2022

2013 conference paper

The application of modeling and simulation for animal health (therapeutics): Gaps, challenges and opportunities

Proceedings of the 18th American Academy of Veterinary Pharmacology and Therapeutics Biennial Symposium. Presented at the 18th American Academy of Veterinary Pharmacology and Therapeutics Biennial Symposium, Potomac, MD.

By: J. Riviere

Event: 18th American Academy of Veterinary Pharmacology and Therapeutics Biennial Symposium at Potomac, MD

Source: NC State University Libraries
Added: May 27, 2022

2013 chapter

Transforming the animal health regulatory system for the 21st century. The Institute of Computational Comparative Medicine and the Animal Health Regulatory Science Initiative

In Proceedings One Hundred and Seventeenth Annual Meeting of the United States Animal Health Association (p. 136). https://www.usaha.org/upload/Proceedings/USAHAProceedings-2013-117th.pdf

By: R. Gehring & J. Riviere

Event: 107th Annual Meeting of the United States Animal Health Association at San Diego, CA on October 17-23, 2013

Source: NC State University Libraries
Added: June 17, 2022

2013 journal article

Use of population pharmacokinetic modeling and Monte Carlo simulation to capture individual animal variability in the prediction of flunixin withdrawal times in cattle

Journal of Veterinary Pharmacology and Therapeutics, 36(3), 248–257.

By: H. Wu n, R. Baynes n, T. Leavens n, L. Tell* & J. Riviere*

MeSH headings : Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle / blood; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Computer Simulation; Drug Administration Routes; Drug Residues / pharmacokinetics; Female; Liver / metabolism; Male; Models, Biological; Monte Carlo Method
TL;DR: This study questions the use of small groups of healthy animals to determine WDTs for drugs intended for administration to large diverse populations and may warrant a reevaluation of the current procedure for establishing WDT to prevent violative residues of flunixin. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Vasomodulation Influences on the Transdermal Delivery of Ibuprofen

Journal of Pharmaceutical Sciences, 102(11), 4072–4078.

By: S. Carter*, Z. Zhu*, G. Varadi*, A. Veves* & J. Riviere*

author keywords: transdermal delivery; ibuprofen; vasodilation; blood flow; skin; permeation enhancer; formulation vehicle; pharmacokinetics
MeSH headings : Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Ibuprofen / administration & dosage; Ibuprofen / blood; Ibuprofen / pharmacokinetics; Papaverine / pharmacology; Permeability / drug effects; Rabbits; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Tolazoline / administration & dosage; Tolazoline / pharmacology; Vasodilator Agents / administration & dosage; Vasodilator Agents / pharmacology
TL;DR: Transdermal formulations of ibuprofen containing low concentrations of tolazoline or papaverine increased plasma ib uprofen levels in the presence of passive PE components, and vasodilator enhancement to ibUprofen delivery was evaluated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: December 24, 2021

2013 journal article

What to do about unsafe medicines?

British Medical Journal, 347, 5064,

By: G. Buckley, J. Riviere* & L. Gostin*

MeSH headings : Drug Industry / legislation & jurisprudence; Drug Industry / standards; Female; Humans; Male; Patient Education as Topic; Patient Safety / legislation & jurisprudence; Prescription Drugs / standards; Quality Assurance, Health Care
TL;DR: Because buyers cannot be aware of deceit in the sale of drugs, regulators need to balance the scales. (via Semantic Scholar)
Source: Web Of Science
Added: May 27, 2022

2012 journal article

A Novel Long-Acting Transdermal Fentanyl Solution for Dogs

Journal of Veterinary Pharmacology and Therapeutics, 35(Supplement 2), 1.

Jim Riviere

Ed(s): J. Riviere

Source: NC State University Libraries
Added: June 17, 2022

2012 chapter

Absorption

In E. Hodgson (Ed.), Pesticide Biotransformation and Disposition (pp. 25–52). New York: Elsevier.

By: R. Baynes & J. Riviere

Ed(s): E. Hodgson

Source: NC State University Libraries
Added: June 17, 2022

2012 journal article

Acute vascular effects of nanoparticle infusion in isolated perfused skin

Nanomedicine: Nanotechnology, Biology and Medicine, 8(4), 428–431.

By: J. Riviere n, T. Leavens n, J. Brooks n & N. Monteiro-Riviere n

Contributors: J. Riviere n, T. Leavens n, J. Brooks n & N. Monteiro-Riviere n

author keywords: Nanoparticles; Vascular toxicity; In vitro; Biodistribution
MeSH headings : Animals; Female; Perfusion; Quantum Dots; Skin / blood supply; Skin / pathology; Skin / physiopathology; Sus scrofa; Vascular Resistance / drug effects
TL;DR: Specific nanoparticle infusions were demonstrated to be associated with significant acute vascular physiological effects, and these observations suggest certain nanoparticles infusions may beassociated with acute vascular physiologic effects that merit further attention. (via Semantic Scholar)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Acute vascular effects of nanoparticle infusion in isolated perfused skin

[Poster]. Toxicologist, 126, 18. https://www.toxicology.org/pubs/docs/Tox/2012Tox.pdf

By: J. Riviere, T. Leavens, J. Brooks & N. Monteiro-Riviere

Event: 51st Annual Meeting and ToxExpo at San Francisco, CA on March 11-15, 2012

Source: NC State University Libraries
Added: June 17, 2022

2012 journal article

Challenges obtaining a biowaiver for topical veterinary dosage forms

Journal of Veterinary Pharmacology and Therapeutics, 35(SUPPL. 1), 103–114.

By: R. Baynes n, J. Riviere n, T. Franz, N. Monteiro Riviere n, P. Lehman, M. Peyrou*, P. Toutain*

Contributors: R. Baynes n, J. Riviere n, T. Franz, N. Monteiro-Riviere n, P. Lehman, M. Peyrou*, P. Toutain*

MeSH headings : Administration, Topical; Animals; Dosage Forms; Drug Administration Routes; Legislation, Drug; Species Specificity; Therapeutic Equivalency; Veterinary Drugs / administration & dosage; Veterinary Drugs / chemistry; Veterinary Drugs / pharmacokinetics
TL;DR: The focus of this paper is to address several of the challenges associated with determining the BE of these locally acting drugs and critically examine the current technological advances that can act as a surrogate for clinical trials. (via Semantic Scholar)
Sources: Crossref, Web Of Science, ORCID
Added: August 6, 2018

2012 chapter

Dermal Toxicity

In R. Gupta (Ed.), Veterinary Toxicology: Basic and Clinical Principles (2nd ed., pp. 337–350,). New York: Elsevier.

By: F. Muhammad & J. Riviere

Ed(s): R. Gupta

Source: NC State University Libraries
Added: June 17, 2022

2012 journal article

Development of a physiologically based pharmacokinetic model to predict tulathromycin distribution in goats

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(2), 121–131.

By: T. Leavens n, L. Tell*, K. Clothier*, R. Griffith*, R. Baynes n & J. Riviere n

MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Computer Simulation; Disaccharides / blood; Disaccharides / pharmacokinetics; Goats / blood; Goats / metabolism; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Models, Biological; Sensitivity and Specificity; Software; Tissue Distribution
TL;DR: The developed model and compilation of physiological parameters for goats provide initial tools that can be used as a basis for predicting withdrawal times of drugs in this minor species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 chapter

Distribution and Pharmacokinetic Models

In E. Hodgson (Ed.), Pesticide Biotransformation and Disposition (pp. 117–148). New York: Elsevier.

By: R. Baynes, K. Dix & J. Riviere

Ed(s): E. Hodgson

Source: NC State University Libraries
Added: June 17, 2022

2012 journal article

Effect of eight different nanoparticles of different sizes and shapes on human epidermal keratinocytes

[Conference abstract]. Journal of Investigative Dermatology, 132(S1), S52.

By: N. Monteiro-Riviere, A. Inman, S. Mathur, M. Muhammed, B. Fadeel & J. Riviere

Source: NC State University Libraries
Added: June 17, 2022

2012 book

Ensuring Safe Foods and Medical Products through Strong Regulatory Systems Abroad

https://nap.nationalacademies.org/catalog/13296/ensuring-safe-foods-and-medical-products-through-stronger-regulatory-systems-abroad

Jim Riviere

Ed(s): J. Riviere & G. Buckley

Source: NC State University Libraries
Added: June 17, 2022

2012 journal article

Evaluation of factors important in modeling plasma concentrations of tetracycline hydrochloride administered in water in swine

AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(10), 1641–1649.

By: S. Mason n, G. Almond*, J. Riviere* & R. Baynes*

TL;DR: The factors found to be of importance, combined with knowledge of the individual pharmacokinetic and chemical properties of medications currently approved for administration in water, may be useful in more prudent administration of approved medications administered to swine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Experimental factors affecting in vitro absorption of six model compounds across porcine skin

Toxicology in Vitro, 26(7), 1191–1198.

By: D. Karadzovska, J. Brooks* & J. Riviere*

author keywords: Dermal absorption/penetration; Diffusion cells; Saturated; Unsaturated; Finite; Infinite; Albumin
MeSH headings : Administration, Cutaneous; Animals; Cattle; Diffusion; Female; In Vitro Techniques; Models, Biological; Permeability / drug effects; Serum Albumin, Bovine / metabolism; Skin / drug effects; Skin / metabolism; Skin Absorption; Swine; Xenobiotics / administration & dosage; Xenobiotics / pharmacokinetics
TL;DR: The overall results emphasize the importance of experimental design and confirm previous findings that identified dose volume, saturation level and vehicle as the main sources of variation in the in vitro assessment of dermal absorption, whilst diffusion cell model and the presence/absence of BSA in the receptor phase had minimal effect. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018

2012 journal article

In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps

JOURNAL OF APPLIED TOXICOLOGY, 32(11), 913–919.

By: T. Leavens n, N. Monteiro-Riviere n, A. Inman n, J. Brooks n, S. Oldenburg* & J. Riviere n

Contributors: T. Leavens n, N. Monteiro-Riviere n, A. Inman n, J. Brooks n, S. Oldenburg* & J. Riviere n

author keywords: silver nanoparticles; biodistribution; skin
MeSH headings : Animals; Metal Nanoparticles / chemistry; Nanoparticles / chemistry; Perfusion; Silver / chemistry; Silver / pharmacokinetics; Skin / metabolism; Swine / metabolism; Tissue Distribution
TL;DR: The objective of the present study was to quantify the local biodistribution of two types of Ag nanoparticles, Ag‐citrate and Ag‐silica, in the isolated perfused porcine skin flap (IPPSF), and found no detectable elimination of Ag from the system. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2012 conference paper

In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps

[Poster]. Toxicologist, 126, 17. https://www.toxicology.org/pubs/docs/Tox/2012Tox.pdf

By: T. Leavens, N. Monteiro-Riviere, A. Inman, J. Brooks, S. Oldenburg & J. Riviere

Event: 51st Annual Meeting and ToxExpo at San Francisco, CA on March 11-15, 2012

Source: NC State University Libraries
Added: June 17, 2022

2012 journal article

LACK OF HYDROXYLATED FULLERENE TOXICITY AFTER INTRAVENOUS ADMINISTRATION TO FEMALE SPRAGUE-DAWLEY RATS

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 75(7), 367–373.

By: N. Monteiro-Riviere n, K. Linder n, A. Inman n, J. Saathoff n, X. Xia n & J. Riviere n

Contributors: N. Monteiro-Riviere n, K. Linder n, A. Inman n, J. Saathoff n, X. Xia n & J. Riviere n

MeSH headings : Animals; Blood Chemical Analysis; Drug Administration Schedule; Female; Fullerenes / administration & dosage; Fullerenes / chemistry; Fullerenes / toxicity; Injections, Intravenous; Liver / drug effects; Lymphocytes / drug effects; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / toxicity; Rats; Rats, Sprague-Dawley; Thymus Gland / drug effects; Toxicity Tests, Acute; Urinalysis
TL;DR: These experiments suggest that this fullerol was well tolerated after iv administration to rats, and no clinically significant chemistry changes were observed after treatment. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 conference paper

Mapping the surface adsorption forces of nanomaterials in biological systems

Presented at the NIEHS Nanotechnology Health Implications Research Consortium Meeting, Research Triangle Park, NC.

By: J. Riviere, X. Xia & N. Monteiro-Riviere

Event: NIEHS Nanotechnology Health Implications Research Consortium Meeting at Research Triangle Park, NC on January 26-27, 2012

Source: NC State University Libraries
Added: July 29, 2022

2012 chapter

Nanoscale feed ingredients and animal and human health

In J. Fink-Gremmels (Ed.), Animal feed contamination : effects on livestock and food safety (pp. 540–553). Philadelphia, PA: Woodhead Publishing.

By: J. Riviere

Ed(s): J. Fink-Gremmels

Source: NC State University Libraries
Added: June 17, 2022

2012 conference paper

Pharmacokinetics and milk elimination of flunixin in dairy cattle following different routes of administration

Waltman, L., Smith, G. W., Leavens, T. L., Baynes, R. E., & Riviere, J. E. (2012, June 3). Abstract presented at the 27th World Buiatrics Congress, Lisbon, Portugal.

By: L. Waltman, G. Smith, T. Leavens, R. Baynes & J. Riviere

Event: 27th World Buiatrics Congress at Lisbon, Portugal on June 3-8, 2012

Source: NC State University Libraries
Added: June 17, 2022

2012 journal article

Pharmacokinetics and tissue elimination of tulathromycin following subcutaneous administration in meat goats

AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(10), 1634–1640.

By: J. Romanet*, G. Smith*, T. Leavens*, R. Baynes*, S. Wetzlich, J. Riviere*, L. Tell

MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Disaccharides / blood; Disaccharides / pharmacokinetics; Female; Goats / blood; Goats / metabolism; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Injections, Subcutaneous / veterinary; Male; Tandem Mass Spectrometry / veterinary; Time Factors; Tissue Distribution
TL;DR: The tissue depletion profile of tulathromycin was determined and an appropriate slaughter withdrawal interval in meat goats after multiple SC injections of the drug was determined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 conference paper

Pharmacokinetics and tissue elimination of tulathromycin following subcutaneous administration in meat goats

Smith, G. W., Romanet, J. L., Leavens, T. L., Tell, L. A., Baynes, R. E., & Riviere, J. E. (2012, June). Abstract presented at the 27th World Buiatrics Congress, Lisbon, Portugal.

By: G. Smith, J. Romanet, T. Leavens, L. Tell, R. Baynes & J. Riviere

Event: 27th World Buiatrics Congress at Lisbon, Portugal on June 3-8, 2012

Source: NC State University Libraries
Added: June 17, 2022

2012 journal article

Plasma pharmacokinetics and milk residues of flunixin and 5-hydroxy flunixin following different routes of administration in dairy cattle

Journal of Dairy Science, 95(12), 7151–7157.

By: L. Kissell n, G. Smith n, T. Leavens n, R. Baynes n, H. Wu n & J. Riviere n

author keywords: flunixin; residue; pharmacology
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / analysis; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / analysis; Clonixin / blood; Clonixin / pharmacokinetics; Drug Residues / analysis; Female; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Injections, Subcutaneous / veterinary; Milk / chemistry
TL;DR: Cattle that received FLU by the approved (intravenous) route consistently eliminated the drug before the approved withdrawal times; however, residues can persist beyond these approved times following intramuscular or subcutaneous administration. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020

2012 chapter

Potential Health Risks of Nanoparticles

In Q. Huang (Ed.), Nanotechnology in the Food, Beverage and Nutraceutical Industries (pp. 40–55). Cambridge: Woodhead Publishing.

By: J. Riviere

Ed(s): Q. Huang

Source: NC State University Libraries
Added: June 17, 2022

2012 journal article

Quantum dot penetration into viable human skin

NANOTOXICOLOGY, 6(2), 173–185.

By: T. Prow*, N. Monteiro-Riviere n, A. Inman n, J. Grice*, X. Chen*, X. Zhao*, W. Sanchez*, A. Gierden* ...

Contributors: T. Prow*, N. Monteiro-Riviere n, A. Inman n, J. Grice*, X. Chen*, X. Zhao*, W. Sanchez*, A. Gierden* ...