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Works (1101)
Updated: December 11th, 2024 05:01
2024 article
Development of a physiologically based pharmacokinetic model for flunixin in cattle and swine following dermal exposure
Wu, X., Chen, Q., Chou, W.-C., Maunsell, F. P., Tell, L. A., Baynes, R. E., … Lin, Z. (2024, November 12). TOXICOLOGICAL SCIENCES, Vol. 11.
author keywords: flunixin meglumine; cattle; swine; physiologically based pharmacokinetic (PBPK) modeling; food safety; risk assessment; computational toxicology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2024
2024 journal article
Predicting tissue distribution and tumor delivery of nanoparticles in mice using machine learning models
JOURNAL OF CONTROLLED RELEASE, 374, 219–229.
author keywords: Nanoparticles; Artificial intelligence; Machine learning; Nanomedicine; Drug delivery; Biodistribution; Quantitative structure-activity relationship; (QSAR); Deep neural network model
open access via doi.org (publisher)
Sources: Web Of Science, NC State University Libraries
Added: September 3, 2024
2023 journal article
An artificial intelligence-assisted physiologically-based pharmacokinetic model to predict nanoparticle delivery to tumors in mice
JOURNAL OF CONTROLLED RELEASE, 361, 53–63.
author keywords: Artificial intelligence; Machine learning; Physiologically based pharmacokinetic; modeling; Nanomedicine; Drug delivery; Nanotechnology
TL;DR:
An AI-assisted physiologically based pharmacokinetic (PBPK) model is established by integrating an AI-based quantitative structure-activity relationship (QSAR) model with a PBPK model to simulate tumor-targeted delivery efficiency (DE) and biodistribution of various NPs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 7, 2023
2023 journal article
Development and application of an interactive generic physiologically based pharmacokinetic (igPBPK) model for adult beef cattle and lactating dairy cows to estimate tissue distribution and edible tissue and milk withdrawal intervals for per- and polyfluoroalkyl substances (PFAS)
FOOD AND CHEMICAL TOXICOLOGY, 181.
author keywords: Per-and polyfluoroalkyl substances (PFAS); Chemical residue; Interactive generic physiologically based pharmacokinetic (igPBPK) modeling; Withdrawal interval; Food safety; Risk assessment
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 20, 2023
2023 journal article
Development of machine learning algorithms to estimate maximum residue limits for veterinary medicines
FOOD AND CHEMICAL TOXICOLOGY, 179.
author keywords: Unestablished MRL; Veterinary drugs; Machine learning; International market and trade; Published commodity (animal organ); Data resampling techniques
TL;DR:
This study demonstrates unestablished MRLs can be reliably predicted for under-represented food commodity groups using machine learning (ML) and provides the first study to apply ML algorithms in regulatory food animal medicine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 25, 2023
2023 journal article
Meta-Analysis of Nanoparticle Distribution in Tumors and Major Organs in Tumor-Bearing Mice
ACS NANO, 17(20), 19810–19831.
author keywords: Nanoparticle; Tumor delivery; Tissue distribution; Cancer; Nanomedicine
TL;DR:
An updated version of “Nano-Tumor Database” is reported, which increases the number of time-dependent concentration data sets for different nanoparticles (NPs) in tumors from the previous version of 376 data sets to 534 data sets with 2345 data points from 297 studies published from 2005 to 2021.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 10, 2023
2022 journal article
A web-based interactive physiologically based pharmacokinetic (iPBPK) model for meloxicam in broiler chickens and laying hens
FOOD AND CHEMICAL TOXICOLOGY, 168.
author keywords: Meloxicam; Food Animal Residue Avoidance Databank (FARAD); Physiologically based pharmacokinetic (PBPK) modeling; Broiler chicken; Laying hen; Food safety
MeSH headings : Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chickens; Eggs; Female; Internet; Meloxicam
TL;DR:
The model provides a useful and flexible tool for risk assessment and management of residues for meat and eggs from chickens treated with meloxicam and will serve as a basis for extrapolation to other NSAID drugs and other poultry species to aid animal-derived food safety assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 12, 2022
2022 article
An Interactive Generic Physiologically Based Pharmacokinetic (igPBPK) Modeling Platform to Predict Drug Withdrawal Intervals in Cattle and Swine: A Case Study on Flunixin, Florfenicol, and Penicillin G
Chou, W.-C., Tell, L. A., Baynes, R. E., Davis, J. L., Maunsell, F. P., Riviere, J. E., & Lin, Z. (2022, June 1). TOXICOLOGICAL SCIENCES, Vol. 6.
author keywords: drug residue; Food Animal Residue Avoidance Databank (FARAD); food safety; interactive generic physiologically based pharmacokinetic (igPBPK) model; withdrawal interval (WDI)
MeSH headings : Animals; Cattle; Clonixin / analogs & derivatives; Drug Residues / analysis; Drugs, Generic; Models, Biological; Penicillin G / pharmacokinetics; Swine; Thiamphenicol / analogs & derivatives
TL;DR:
A user-friendly generic PBPK platform that can predict tissue residues and estimate WDIs for multiple drugs including flunixin, florfenicol, and penicillin G in cattle and swine is developed and provides a basis for extrapolating to other drugs and species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 20, 2022
2022 article
Mechanisms of toxicity and residue considerations of rodenticide exposure in food Animals-a FARAD perspective
Mercer, M. A., Davis, J. L., Riviere, J. E., Baynes, R. E., Tell, L. A., Jaberi-Douraki, M., … Lin, Z. (2022, March 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 260, pp. 514–523.
MeSH headings : Animals; Drug Residues; Rodenticides / toxicity
TL;DR:
T Food Animal Residue Avoidance Databank (FARAD) frequently receives requests for withdrawal interval recommendations following inadvertent exposure of food animals to various environmental contaminants and pesticides such as rodenticides.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 28, 2022
2022 journal article
Predicting Nanoparticle Delivery to Tumors Using Machine Learning and Artificial Intelligence Approaches
INTERNATIONAL JOURNAL OF NANOMEDICINE, 17, 1365–1379.
Contributors: Z. Lin n, W. Chou *, Y. Cheng *, C. He *, N. Monteiro-Riviere n & n
author keywords: artificial intelligence; machine learning; physiologically based pharmacokinetic modeling; nanomedicine; drug delivery; nanotechnology
MeSH headings : Artificial Intelligence; Humans; Machine Learning; Nanoparticles; Neoplasms / drug therapy; Neural Networks, Computer
TL;DR:
The deep neural network model adequately predicted the delivery efficiency of different NPs to different tumors and it outperformed all other machine learning methods; including random forest, support vector machine, linear regression, and bagged model methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 30, 2022
2022 review
Toxicokinetics, dose-response, and risk assessment of nanomaterials: Methodology, challenges, and future perspectives
[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 14(6).
author keywords: dose-response assessment; nanomaterials; nanoparticles; risk assessment; toxicokinetics
MeSH headings : Animals; Humans; Toxicokinetics; Risk Assessment; Nanostructures / toxicity; Nanomedicine; Tissue Distribution
TL;DR:
This article reviews the methods for conducting toxicokinetics, hazard identification, dose-response, exposure, and risk assessment studies of nanomaterials, identify the knowledge gaps, and discuss the challenges remaining and provides the rationale behind the appropriate design ofnanomaterial plasma toxicokinetic and tissue distribution studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: December 19, 2022
2021 content posted
Data-driven methodology for discovery and response to pulmonary symptomology in hypertension through AI and machine learning: Application to COVID-19 related pharmacovigilance
Source: Crossref
Added: August 12, 2021
2021 journal article
Development and Application of an interactive Physiologically Based Pharmacokinetic (iPBPK) Model to Predict Oxytetracycline Tissue Distribution and Withdrawal Intervals in Market-Age Sheep and Goats
Toxicological Sciences, 183(2), 253–268.
author keywords: drug residue; Food Animal Residue Avoidance Databank (FARAD); food safety; interactive physiologically based pharmacokinetic (iPBPK) model; oxytetracycline; withdrawal interval (WDI)
MeSH headings : Animals; Anti-Bacterial Agents; Drug Residues / analysis; Goats; Models, Biological; Oxytetracycline; Sheep; Tissue Distribution
TL;DR:
This iPBPK model provides a useful tool to estimate WDIs for OTC after extralabel use in small ruminants to ensure food safety and serves as a basis for extrapolation to other tetracycline drugs and other food animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 12, 2021
2021 journal article
Honey bee medicine for veterinarians and guidance for avoiding violative chemical residues in honey
Journal of the American Veterinary Medical Association, 259(8), 860–873.
MeSH headings : Animals; Bees; Honey; Humans; Veterinarians
TL;DR:
People have long recognized and appreciated honey bees for their important role in pollinating commercial crops while also providing natural products for use in the food, cosmetic, and pharmaceutical industries.
(via Semantic Scholar)
Source: NC State University Libraries
Added: May 21, 2022
2021 chapter
Percutaneous Absorption of Chemical Mixtures
In N. Dragićević (Ed.), Percutaneous Absorption (5th ed., pp. 305–314).
Ed(s): N. Dragićević
Source: Crossref
Added: August 12, 2021
2021 journal article
Pulmonary adverse drug event data in hypertension with implications on COVID-19 morbidity
SCIENTIFIC REPORTS, 11(1).
MeSH headings : Angiotensin Receptor Antagonists / adverse effects; Angiotensin-Converting Enzyme Inhibitors / adverse effects; Antihypertensive Agents / adverse effects; COVID-19 / epidemiology; Comorbidity; Hospital Mortality; Humans; Hypertension / drug therapy; Hypertension / epidemiology; Indoles / adverse effects; Quinapril / adverse effects; Retrospective Studies; COVID-19 Drug Treatment
TL;DR:
This study suggests that specific members of the ACEI antihypertensive class (quinapril and trandolapril) have a significantly higher cluster of pulmonary ADEs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 26, 2021
2021 journal article
Update on withdrawal intervals following extralabel use of procaine penicillin G in cattle and swine
Journal of the American Veterinary Medical Association, 260(1), 50–55.
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Cattle; Drug Residues; Penicillin G Procaine / therapeutic use; Swine
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 7, 2022
2020 journal article
A study to assess the correlation between plasma, oral fluid and urine concentrations of flunixin meglumine with the tissue residue depletion profile in finishing-age swine
BMC Veterinary Research, 16(1).
author keywords: Flunixin meglumine; Food safety; Pharmacokinetics; Physiologically based pharmacokinetic (PBPK) model; Swine; Tissue residue
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / urine; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Clonixin / urine; Food Contamination / analysis; Pork Meat / analysis; Saliva / chemistry; Sus scrofa / physiology
TL;DR:
Results indicate untreated pigs can be exposed to flunixin by shared housing with FM-treated pigs due to environmental contamination, and the PBPK model adequately correlated plasma, oral fluid and urine concentrations of flunxin with residue depletion profiles in liver, kidney, and muscle of finishing-age pigs, especially within 24 h after dosing.
(via Semantic Scholar)
Source: Crossref
Added: August 13, 2021
2020 conference paper
Development and application of an interactive physiological based pharmacokinetic (iPBPK) model interface to estimate withdrawal intervals for penicillin G in cattle and swine
The Toxicologist, 174(1), 458.
Event: 59th Society of Toxicology annual meeting & ToxExpo at Anaheim, California on March 15-19, 2020
Source: NC State University Libraries
Added: August 13, 2021
2020 journal article
Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach
ACS Nano, 14(3), 3075–3095.
Contributors: Y. Cheng *, C. He *, *, N. Monteiro-Riviere* & Z. Lin *
author keywords: advanced material; drug delivery; nanomedicine; nanoparticle; physiologically based pharmacokinetic modeling; tissue biothstribution; tumor delivery
MeSH headings : Animals; Disease Models, Animal; Drug Carriers / chemistry; Drug Delivery Systems; Gold / administration & dosage; Gold / chemistry; Gold / pharmacokinetics; Injections, Intravenous; Male; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Neoplasms / chemistry; Neoplasms / metabolism; Tissue Distribution
TL;DR:
The potential causes of this poor delivery efficiency were explored using the more mechanistic PBPK perspective applied to a subset of gold nanoparticles and it was found that low delivery efficiency was associated with low distribution and permeability coefficients at the tumor site.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: March 5, 2020
2020 journal article
Pharmacovigilance in patients with diabetes: A data-driven analysis identifying specific RAS antagonists with adverse pulmonary safety profiles that have implications for COVID-19 morbidity and mortality
Journal of the American Pharmacists Association, 60(6), e145–e152.
MeSH headings : Angiotensin Receptor Antagonists / adverse effects; Angiotensin Receptor Antagonists / therapeutic use; Angiotensin-Converting Enzyme 2 / metabolism; Angiotensin-Converting Enzyme Inhibitors / adverse effects; Angiotensin-Converting Enzyme Inhibitors / therapeutic use; COVID-19 / complications; COVID-19 / metabolism; COVID-19 / mortality; China / epidemiology; Diabetes Mellitus / drug therapy; Diabetes Mellitus / metabolism; Diabetic Nephropathies / complications; Diabetic Nephropathies / metabolism; Diabetic Nephropathies / prevention & control; Humans; Morbidity / trends; Pharmacovigilance; Prevalence; Renin-Angiotensin System / drug effects; Respiratory System / drug effects; Respiratory System / metabolism; SARS-CoV-2
TL;DR:
It is suggested that pharmacists and clinicians will need to consider specific medication’s adverse event profile, particularly captopril, and how this profile may affect infections and other acute disease states that alter pulmonary function, such as COVID-19.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 12, 2021
2020 journal article
Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part 1: Cattle and Swine
The Toxicologist, 174(1), 461.
Event: 59th Society of Toxicology annual meeting & ToxExpo at Anaheim, California on March 15-19, 2020
Source: NC State University Libraries
Added: August 13, 2021
2020 review
Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and swine
[Review of ]. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 43(5), 385–420.
author keywords: blood flow; food safety; organ weight; physiologically based pharmacokinetic model; withdrawal interval
MeSH headings : Animals; Cattle / physiology; Drug Residues; Models, Biological; Pharmaceutical Preparations / metabolism; Pharmacokinetics; Swine / physiology
TL;DR:
These compiled data provide a comprehensive physiological parameter database for developing PBPK models of chemicals in cattle and swine to support animal‐derived food safety assessment and provide a basis to compile data in other food animal species, including goats, sheep, chickens, and turkeys.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 31, 2020
2020 review
Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part II: Chicken and turkey
[Review of ]. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 44(4), 423–455.
author keywords: blood flow; Food Animal Residue Avoidance Databank (FARAD); food safety; organ weight; physiologically based pharmacokinetic (PBPK) model
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 21, 2020
2020 journal article
Physiological parameter values for physiologically based pharmacokinetic models in food‐producing animals. Part III: Sheep and goat
Journal of Veterinary Pharmacology and Therapeutics, 44(4), 456–477.
author keywords: blood flow; food animal residue avoidance databank; food safety; organ weight; physiologically based pharmacokinetic model
MeSH headings : Animals; Cattle; Chickens; Goats; Models, Biological; Organ Size; Sheep; Swine
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Crossref, ORCID
Added: August 13, 2021
2020 conference paper
Physiologically based pharmacokinetic modeling and simulation of nanoparticle delivery to tumors in mice
The Toxicologist, 174(1), 460.
Event: 59th Society of Toxicology annual meeting & ToxExpo at Anaheim, California on March 15-19, 2020
Source: NC State University Libraries
Added: August 13, 2021
2019 journal article
An integrated experimental and physiologically based pharmacokinetic modeling study of penicillin G in heavy sows
Journal of Veterinary Pharmacology and Therapeutics, 42(4), 461–475.
author keywords: extralabel withdrawal interval; food safety; heavy sow; physiologically based pharmacokinetic (PBPK) model; procaine penicillin G (PPG); tissue residue
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Body Weight; Computer Simulation; Dose-Response Relationship, Drug; Drug Residues; Female; Models, Biological; Penicillin G / administration & dosage; Penicillin G / pharmacokinetics; Swine / blood; Swine / metabolism; Swine / urine
TL;DR:
The results showed that antemortem testing of urine provided potential correlation with tissue residue levels and provided a tool to predict proper withdrawal intervals after extralabel use of penicillin G in heavy sows, thereby helping safety assessment of sow-derived meat products.
(via Semantic Scholar)
Source: Crossref
Added: August 13, 2021
2019 conference paper
Assessing delivery efficiency of nanoparticles to tumors in tumor-bearing mice using a physiologically based pharmacokinetic modeling and simulation approach
The Toxicologist, 168(1), 476–477,
Event: 58th Society of Toxicology annual meeting & ToxExpo at Baltimore, Maryland on March 10-14, 2019
Source: NC State University Libraries
Added: August 13, 2021
2019 journal article
Development and application of a population physiologically based pharmacokinetic model for florfenicol and its metabolite florfenicol amine in cattle
FOOD AND CHEMICAL TOXICOLOGY, 126, 285–294.
author keywords: Physiologically based pharmacokinetic (PBPK) model; Withdrawal interval; Florfenicol; Florfenicol amine; Cattle
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Cattle; Cattle Diseases / drug therapy; China; Chromatography, High Pressure Liquid; Drug Administration Routes; Drug Residues / analysis; Drug Residues / metabolism; Drug Residues / pharmacokinetics; Kidney / drug effects; Liver / drug effects; Models, Biological; Thiamphenicol / administration & dosage; Thiamphenicol / analogs & derivatives; Thiamphenicol / analysis; Thiamphenicol / metabolism; Thiamphenicol / pharmacokinetics
TL;DR:
A population physiologically based pharmacokinetic (PBPK) model to predict the concentrations of FF and its metabolite, florfenicol amine, in cattle after four different routes of administration, and to calculate and compare the withdrawal intervals (WDIs) with approved withdrawal times based on different marker residues and their MRLs or tolerances.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 15, 2019
2019 journal article
Extralabel drug use in wildlife and game animals
Journal of the American Veterinary Medical Association, 255(5), 555–568.
MeSH headings : Animals; Animals, Wild; Off-Label Use / veterinary
TL;DR:
Wildlife or game animals will refer to free-ranging nondomesticated mammals, reptiles, and bird species as well as animals that are confined or farm raised and subsequently hunted for personal consumption or slaughtered for commercial purposes and thus are considered food-producing animals.
(via Semantic Scholar)
Source: Crossref
Added: August 13, 2021
2019 conference paper
Integration of Food Animal Residue Avoidance Databank (FARAD) Empirical Methods for Drug Withdrawal Interval Determination with a Mechanistic Population-Based Interactive Physiologically Based Pharmacokinetic (iPBPK) Modeling Platform: Example for Flunixin Meglumine Administration
The Toxicologist, 168(1), 191.
Event: 58th Society of Toxicology annual meeting & ToxExpo at Baltimore, Maryland on March 10-14, 2019
Source: NC State University Libraries
Added: August 13, 2021
2019 journal article
Integration of Food Animal Residue Avoidance Databank (FARAD) empirical methods for drug withdrawal interval determination with a mechanistic population-based interactive physiologically based pharmacokinetic (iPBPK) modeling platform: example for flunixin meglumine administration
Archives of Toxicology, 93(7), 1865–1880.
author keywords: Flunixin; Interactive physiologically based pharmacokinetic (iPBPK) model; Food safety; Drug residues; Withdrawal intervals (WDIs); Food Animal Residue Avoidance Databank (FARAD)
MeSH headings : Animals; Animals, Domestic / metabolism; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Databases, Factual; Drug Residues / pharmacokinetics; Food Contamination / analysis; Food Contamination / prevention & control; Food Safety / methods; Models, Biological; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
A new PBPK model for both cattle and swine after administration of flunixin meglumine was developed and it can be applied to develop new models for other drugs in other food animal species, thereby facilitating the application of P BPK modeling in WDI estimation and food safety assessment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 12, 2019
2019 journal article
Making Sense of Pharmacovigilance and Drug Adverse Event Reporting: Comparative Similarity Association Analysis Using AI Machine Learning Algorithms in Dogs and Cats
Topics in Companion Animal Medicine, 37, 100366.
author keywords: similarity association; drug adverse events; artificial intelligence; pharmacovigilance machine learning algorithms; graphical LASSO; companion animals
MeSH headings : Algorithms; Animals; Artificial Intelligence; Cats; Dogs; Drug Combinations; Drug-Related Side Effects and Adverse Reactions / veterinary; Ivermectin / adverse effects; Ivermectin / analogs & derivatives; Machine Learning; Macrolides / adverse effects; Pharmacovigilance
TL;DR:
A comparative analysis of ADEs based on an artificial intelligence (AI) approach for the 5 robust similarity methods revealed high ADE associations for 2 drugs used in dogs and cats, and showed that the cosine method significantly outperformed all the other methods by correctly detecting and validating ADEs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 13, 2021
2019 journal article
Novel Data Sharing Agreement to Accelerate Big Data Translational Research Projects in the One Health Sphere
Topics in Companion Animal Medicine, 37, 100367.
author keywords: data sharing; one health; public-private partnership; data analysis; legal issues; translational research; big data
MeSH headings : Animals; Big Data; Data Anonymization; Health Insurance Portability and Accountability Act; Humans; Information Dissemination / methods; One Health; Translational Research, Biomedical / organization & administration; United States
TL;DR:
The 1DATA Project examined and overcome some of the barriers to sharing data generated by researchers and clinicians working with for-profit companies, and the ways those obstacles can be surmounted via a novel form of Master Sharing Agreement are discussed.
(via Semantic Scholar)
Source: Crossref
Added: August 13, 2021
2018 conference paper
A general physiologically-based pharmacokinetic model for gold nanoparticles of different sizes with multiple administration routes in rats
The Toxicologist, 162(1), 526.
Event: 57th Society of Toxicology annual meeting and ToxExpo at San Antonio, Texas on March 11-15, 2018
Source: NC State University Libraries
Added: August 13, 2021
2018 chapter
Absorption, Distribution, Metabolism, and Elimination
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 8–40). Ames, Iowa: Wiley-Blackwell.
Ed(s): & M. Papich
Source: NC State University Libraries
Added: August 13, 2021
2018 chapter
Aminoglycoside Antibiotics
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 877–902). Ames, Iowa: Wiley-Blackwell.
Ed(s): & M. Papich
Source: NC State University Libraries
Added: August 13, 2021
2018 chapter
Antiarrhythmic Agents
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 537–552). Ames, Iowa: Wiley-Blackwell.
Ed(s): & M. Papich
Source: NC State University Libraries
Added: August 13, 2021
2018 conference paper
Application of population physiologically-based pharmacokinetic model for penicillin G in dairy cows to facilitate food safety assessment
The Toxicologist, 162(1), 526.
Event: 57th Society of Toxicology annual meeting at San Antonio, Texas on March 11-15, 2018
Source: NC State University Libraries
Added: August 13, 2021
2018 journal article
Automation and applications of the tolerance limit method in estimating meat withdrawal periods for veterinary drugs
COMPUTERS AND ELECTRONICS IN AGRICULTURE, 146, 125–135.
author keywords: Withdrawal time calculator; R studio; Maximum residue limit; Tolerance; US FDA
TL;DR:
A novel program provides a platform to calculate a withdrawal period recommendation for any drug in any class of animal for various regulatory body standards and could be very helpful in cases of extra-label drug use in food animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2018 chapter
Chemical Residues in Tissues of Food Animals
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 1469–1480). Ames, Iowa: Wiley-Blackwell.
Ed(s): & M. Papich
Source: NC State University Libraries
Added: August 13, 2021
2018 journal article
Consequences of fipronil exposure in egg-laying hens
Journal of the American Veterinary Medical Association, 253(1), 57–60.
MeSH headings : Animal Feed / analysis; Animals; Chickens / metabolism; Europe; Female; Food Contamination / prevention & control; Food Safety; Ovum / metabolism; Pesticides / adverse effects; Pyrazoles / adverse effects
TL;DR:
Concerns with fipronil use or exposure in poultry and the difficulties associated with developing data-driven meat or egg withdrawal intervals are explained.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2018 chapter
Dermatopharmacology: Drugs Acting Locally on the Skin
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 1278–1301). Ames, Iowa: Wiley-Blackwell.
Ed(s): & M. Papich
Source: NC State University Libraries
Added: August 13, 2021
2018 chapter
Dosage Forms and Veterinary Feed Directives
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 1459–1464). Ames, Iowa: Wiley-Blackwell.
Ed(s): & M. Papich
Source: NC State University Libraries
Added: August 13, 2021
2018 journal article
Editorial
Journal of Veterinary Pharmacology and Therapeutics, 41(3), 355–355.
MeSH headings : Editorial Policies; Periodicals as Topic; Veterinary Medicine
Sources: Web Of Science, Crossref
Added: August 6, 2018
2018 article
Extralabel drug use in small ruminants
Martin, K. L., Clapham, M. O., Davis, J. L., Baynes, R. E., Lin, Z., Vickroy, T. W., … Tell, L. A. (2018, October 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 253, pp. 1001–1009.
MeSH headings : Animals; Drug Residues; Goat Diseases / drug therapy; Goats; Legislation, Drug; Off-Label Use; Sheep; Sheep Diseases / drug therapy; United States; United States Food and Drug Administration; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
The purpose of this digest is to update a previous FARAD Digest2 concerning small ruminants and provide veterinarians with summary information regarding ELDU in smallRuminants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018
2018 book
Handbook of Comparative Pharmacokinetics and Residues of Veterinary Antimicrobials
TL;DR:
This unique publication represents data from the FARAD (Food Animal Residue Avoidance Databank) databank, established by the authors under the auspices of the U.D.A. and contains significant amounts of previously unavailable information.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2018 conference paper
Impact of natural compounds on dermal absorption for consumer products and their computational prediction
The Toxicologist, 162(1), 179.
Event: 57th Society of Toxicology annual meeting & ToxExpo at San Antonio, Texas on March 11-15, 2018
Source: NC State University Libraries
Added: August 13, 2021
2018 journal article
Modeling gold nanoparticle biodistribution after arterial infusion into perfused tissue: effects of surface coating, size and protein corona
Nanotoxicology, 12(10), 1093–1112.
Contributors: *, M. Jaberi-Douraki *, J. Lillich*, T. Azizi *, H. Joo*, K. Choi*, R. Thakkar*, N. Monteiro-Riviere*
author keywords: Biodistribution; gold nanoparticles; cell uptake; skin; pharmacokinetics; nanoparticle vascular distribution
MeSH headings : Animals; Epigastric Arteries; Female; Free Tissue Flaps; Gold / administration & dosage; Gold / chemistry; Gold / pharmacokinetics; Humans; Infusions, Intra-Arterial; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Models, Biological; Nanomedicine; Particle Size; Perfusion; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / chemistry; Skin / blood supply; Skin / metabolism; Surface Properties; Swine; Thioctic Acid / chemistry; Tissue Distribution
TL;DR:
These studies paralleled previous in vitro cell culture studies using the same AuNP in human endothelial and renal proximal tubule cells, hepatocytes, keratinocytes, showing BPEI-AuNP having the greatest uptake, although the presence of a PPC did not reduce IPPSF biodistribution as in the cellculture studies.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: June 27, 2019
2018 chapter
Pharmacokinetics
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 41–64). Ames, Iowa: Wiley-Blackwell.
Ed(s): & M. Papich
Source: NC State University Libraries
Added: August 13, 2021
2018 journal article
Probabilistic Physiologically Based Pharmacokinetic Model for Penicillin G in Milk From Dairy Cows Following Intramammary or Intramuscular Administrations
Toxicological Sciences, 164(1), 85–100.
author keywords: PBPK modeling; dairy cows; food safety; drug residue; Food Animal Residue Avoidance Databank (FARAD); penicillin
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Cattle; Drug Residues / analysis; Female; Food Contamination / analysis; Injections, Intramuscular; Mammary Glands, Animal / metabolism; Meat / analysis; Milk / chemistry; Models, Biological; Penicillin G / administration & dosage; Penicillin G / pharmacokinetics
TL;DR:
The current PBPK model can help predict milk discard interval for penicillin following extralabel use through IM and IMM administrations and showed that even 4 times label dose did not lead to violative tissue residues in healthy dairy cows with IMM infusions.
(via Semantic Scholar)
Source: Crossref
Added: August 13, 2021
2018 journal article
Probabilistic risk assessment of gold nanoparticles after intravenous administration by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling
Nanotoxicology, 12(5), 453–469.
Contributors: Y. Cheng *, *, N. Monteiro-Riviere* & Z. Lin *
author keywords: Gold nanoparticle; computational nanotoxicology; physiologically based pharmacokinetic modeling; probabilistic risk assessment
MeSH headings : Administration, Intravenous; Animals; Bayes Theorem; Gold / administration & dosage; Gold / pharmacokinetics; Gold / toxicity; Humans; Metal Nanoparticles / toxicity; Models, Biological; Monte Carlo Method; Risk Assessment
TL;DR:
The results suggest that under the highest dosing level employed in existing animal studies (worst-case scenario), AuNPs coated with branched polyethylenimine (BPEI) would likely induce ∼90–100% cellular death, implying high cytotoxicity compared to <10% cell death induced by low-to-medium animal dosing levels, which are commonly used in animal studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, ORCID
Added: June 27, 2019
2018 conference paper
Probabilistic risk assessment of gold nanoparticles by integrating in vitro and in vivo toxicity with physiologically-based pharmacokinetic modeling
The Toxicologist, 162(1), 526.
Event: 57th Society of Toxicology annual meeting and ToxExpo at San Antonio, Texas on March 11-15, 2018
Source: NC State University Libraries
Added: August 13, 2021
2018 book
Science Breakthroughs to Advance Food and Agricultural Research by 2030
In SCIENCE BREAKTHROUGHS TO ADVANCE FOOD AND AGRICULTURAL RESEARCH BY 2030 (pp. 1–228).
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 24, 2020
2018 chapter
Tetracycline Antibiotics
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 858–876). Ames, Iowa: Wiley-Blackwell.
Ed(s): & M. Papich
Source: NC State University Libraries
Added: August 13, 2021
2018 journal article
Variation in fluoroquinolone pharmacodynamic parameter values among isolates of two bacterial pathogens of bovine respiratory disease
Scientific Reports, 8(1).
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Bovine Respiratory Disease Complex / drug therapy; Bovine Respiratory Disease Complex / microbiology; Cattle; Fluoroquinolones / pharmacology; Fluoroquinolones / therapeutic use; Mannheimia haemolytica / drug effects; Mannheimia haemolytica / genetics; Mannheimia haemolytica / isolation & purification; Microbial Sensitivity Tests; Models, Biological; Pasteurella multocida / drug effects; Pasteurella multocida / genetics; Pasteurella multocida / isolation & purification; Phenotype
TL;DR:
Investigating the fluoroquinolone enrofloxacin PD against different isolates of two bovine respiratory disease pathogens found variability in the PD parameters Hill-coefficient and Emax may impact the strain’s properties such as growth potential, which can have clinical implications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 13, 2021
2018 book
Veterinary Pharmacology and Therapeutics
(10th ed.). Ames, Iowa: Wiley-Blackwell.
Ed(s): & M. Papich
Source: NC State University Libraries
Added: August 13, 2021
2018 chapter
Veterinary Pharmacology: An Introduction to the Discipline
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (10th ed., pp. 3–7). Ames, Iowa: Wiley-Blackwell.
Ed(s): & M. Papich
Source: NC State University Libraries
Added: August 13, 2021
2017 journal article
Avoiding violative flunixin meglumine residues in cattle and swine
Journal of the American Veterinary Medical Association, 250(2), 182–189.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / chemistry; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Clonixin / analogs & derivatives; Clonixin / chemistry; Clonixin / pharmacokinetics; Drug Residues / pharmacokinetics; Swine
TL;DR:
In the United States, NSAIDs are among the most frequently administered drugs for analgesia in cattle; however, such use is considered extralabel and must be in accordance with AMDUCA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2017 journal article
Biocorona formation on gold nanoparticles modulates human proximal tubule kidney cell uptake, cytotoxicity and gene expression
Toxicology in Vitro, 42, 150–160.
author keywords: Gold nanoparticles; Human proximal tubule cells; Protein corona; Cellular uptake; Gene expression; Mechanisms of toxicity
MeSH headings : Cells, Cultured; Cytokines / metabolism; Gene Expression / drug effects; Gold / administration & dosage; Gold / chemistry; Gold / toxicity; Humans; Kidney Tubules, Proximal / cytology; Metal Nanoparticles / administration & dosage; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Plasma / chemistry; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / chemistry; Serum Albumin / chemistry; Thioctic Acid / chemistry
TL;DR:
These studies clearly showed reduced uptake and cytotoxicity, as well as differentiated gene expression of AuNP with PCs, questioning the utility of in vitro studies using bare NP to assess in vivo effects, suggesting the relative safety of PEG and LA-AuNP as nanomedicine constructs.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: June 27, 2019
2017 journal article
Biological Surface Adsorption Index of Nanomaterials: Modelling Surface Interactions of Nanomaterials with Biomolecules
Advances in Experimental Medicine and Biology, 947, 207–253.
author keywords: Nanoparticles; Surface interactions; BSAI; Bicorona; Physicochemistry; In situ characterization
MeSH headings : Adsorption; Environment; Models, Biological; Models, Theoretical; Nanostructures / chemistry; Nanotechnology / methods; Surface Properties
TL;DR:
This chapter demonstrates the importance of the adsorption of surrounding molecules onto the surface of nanomaterials by forming biocorona and thus impact the bio-identity and fate of those materials.
(via Semantic Scholar)
Source: Web Of Science
Added: February 5, 2022
2017 journal article
Considerations for extralabel drug use in calves
Journal of the American Veterinary Medical Association, 250(11), 1275–1282.
MeSH headings : Animals; Animals, Newborn; Cattle; Drug Labeling; Drug Residues; Food Contamination; Meat; Milk; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
The purpose of this digest is to provide veterinarians with a summary of the considerations for ELDU in both beef and dairy calves as well as calves intended for veal production.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 chapter
Dermatotoxicology: Computational approaches to predicting absorption of complex topical chemical mixtures
In S. Ekins (Ed.), Computational Toxicology (2nd ed., pp. 269–290). New York: John Wiley.
Ed(s): S. Ekins
Source: NC State University Libraries
Added: February 5, 2022
2017 journal article
Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment
Food and Chemical Toxicology, 107, 74–87.
author keywords: Physiologically based pharmacokinetic (PBPK) model; Food safety; Food animal residue avoidance databank (FARAD); Penicillin; Drug residue; Extralabel withdrawal interval
MeSH headings : Animals; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacokinetics; Cattle; Drug Residues / chemistry; Drug Residues / pharmacokinetics; Food Safety; Kidney / chemistry; Liver / chemistry; Meat / analysis; Models, Biological; Muscle, Skeletal / chemistry; Penicillin G / chemistry; Penicillin G / pharmacokinetics; Swine
TL;DR:
A physiologically based pharmacokinetic (PBPK) model is developed to predict drug residues in edible tissues and estimate extended withdrawal intervals for penicillin G in swine and cattle to aid food safety assessment and provide a framework for extrapolation to other food animal species.
(via Semantic Scholar)
Source: Crossref
Added: October 1, 2021
2017 journal article
Guide to FARAD resources: historical and future perspectives
Journal of the American Veterinary Medical Association, 250(10), 1131–1139.
MeSH headings : Animal Husbandry; Animals; Consumer Product Safety; Databases, Factual; Drug Residues; Food Contamination; Meat; United States; United States Department of Agriculture
TL;DR:
The program has dramatically evolved since its inception in terms of data resources, outreach, quantitative tools used to estimate WDIs, precision of estimates, and methods implemented to disseminate information.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Mathematical modeling and simulation in animal health. Part III: Using nonlinear mixed-effects to characterize and quantify variability in drug pharmacokinetics
Journal of Veterinary Pharmacology and Therapeutics, 41(2), 171–183.
author keywords: covariates; nonlinear mixed effects; population pharmacokinetics; sparse sampling; veterinary medicine
MeSH headings : Animal Diseases / drug therapy; Animals; Models, Theoretical; Nonlinear Dynamics; Pharmacokinetics
TL;DR:
Nonlinear mixed effects (NLME) have been purposely designed to characterize the sources of variability in drug disposition and response and can be used to explore the impact of population-associated variables on the relationship between drug administration, systemic exposure, and the levels of drug residues in tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 13, 2021
2017 journal article
Modulation of topical chemical absorption by 14 natural compounds: a quantitative structure permeation (QSPR) analysis of components often found in topical preparations
Cutaneous and Ocular Toxicology, 36(3), 237–252.
Source: NC State University Libraries
Added: February 5, 2022
2017 chapter
Multi-Walled Carbon Nanotube Exposure Alters Protein Expression in Human Keratinocytes
In Nanomedicine in Cancer (pp. 461–485).
Source: Crossref
Added: December 24, 2021
2017 journal article
Nano in-vitro cellular uptake simulator (NICUS): a model to quantitate nanomaterial endocytosis kinetics and intracellular dose
The Toxicologist, 156, 303.
Source: NC State University Libraries
Added: February 5, 2022
2017 journal article
NanoEHS beyond toxicity – focusing on biocorona
Environmental Science: Nano, 4(7), 1433–1454.
TL;DR:
New opportunities concerning nano-biomolecular interactions beyond the scope of toxicity are highlighted, which presents vast new opportunities for screening beneficial material properties and designing greener products from bottom up.
(via Semantic Scholar)
Source: Crossref
Added: October 1, 2021
2017 journal article
Performance Assessment and Translation of Physiologically Based Pharmacokinetic Models From acslX to Berkeley Madonna, MATLAB, and R Language: Oxytetracycline and Gold Nanoparticles As Case Examples
Toxicological Sciences, 158(1), 23–35.
author keywords: acslX; Berkeley Madonna; MATLAB; PBPK modeling; R language
MeSH headings : Animals; Dogs; Gold / blood; Gold / chemistry; Gold / pharmacokinetics; Metal Nanoparticles / chemistry; Models, Biological; Oxytetracycline / blood; Oxytetracycline / pharmacokinetics; Swine; Tissue Distribution
TL;DR:
This tutorial helps beginners learn PBPK modeling, provides suggestions for selecting a suitable tool for future projects, and may lead to the transition from acslX to alternative modeling tools.
(via Semantic Scholar)
Source: Crossref
Added: October 1, 2021
2017 journal article
Pharmacokinetics of Mequindox and Its Marker Residue 1,4-Bisdesoxymequindox in Swine Following Multiple Oral Gavage and Intramuscular Administration: An Experimental Study Coupled with Population Physiologically Based Pharmacokinetic Modeling
Journal of Agricultural and Food Chemistry, 65(28), 5768–5777.
author keywords: food safety; mequindox; physiologically based pharmacokinetic (PBPK) modeling; quinoxaline-N,N-dioxide antibiotics; swine
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Drug Residues / pharmacokinetics; Injections, Intramuscular; Liver / metabolism; Quinoxalines / administration & dosage; Quinoxalines / pharmacokinetics; Swine; Tissue Distribution; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
A flow-limited physiologically based pharmacokinetic (PBPK) model can be used to predict depletion kinetic profiles and tissue residues of MEQ's marker residue M1 in swine and as a foundation for scaling to other quinoxaline-N,N-dioxide antibiotics and to other animal species.
(via Semantic Scholar)
Source: Crossref
Added: October 1, 2021
2017 journal article
Surface chemistry of gold nanoparticles determines the biocorona composition impacting cellular uptake, toxicity and gene expression profiles in human endothelial cells
Nanotoxicology, 11(4), 507–519.
Contributors: P. Chandran *, * & N. Monteiro-Riviere*
author keywords: Biocorona; gold nanoparticles; surface chemistry; endothelial cells; mechanistic toxicology
MeSH headings : Albumins / metabolism; Cell Survival / drug effects; Circular Dichroism; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Gold / chemistry; Gold / toxicity; Human Umbilical Vein Endothelial Cells; Humans; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Particle Size; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / metabolism; Proteomics; Surface Properties; Transcriptome / drug effects
TL;DR:
NP surface chemistry is shown to play the dominant role over size in determining the biocorona composition, which in turn modulates cell uptake, and biological responses, consequently defining the potential safety and efficacy of nanoformulations.
(via Semantic Scholar)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2017 journal article
Zinc Oxide Nanoparticle–Poly I:C RNA Complexes: Implication as Therapeutics against Experimental Melanoma
Molecular Pharmaceutics, 14(3), 614–625.
author keywords: zinc oxide nanoparticles (ZnO-NPs); poly I:C RNA (pIC); binding parameters; antimelanoma; immunology
MeSH headings : Animals; Antineoplastic Agents / pharmacology; Biomarkers, Tumor / metabolism; Cell Death / drug effects; Cell Line, Tumor; Humans; Interferon-gamma / metabolism; Interleukin-6 / metabolism; MAP Kinase Kinase 4 / metabolism; Melanoma, Experimental / drug therapy; Melanoma, Experimental / metabolism; Mice; Mice, Inbred BALB C; Nanoparticles / administration & dosage; Poly I-C / pharmacology; Proto-Oncogene Proteins c-akt / metabolism; RNA / pharmacology; Zinc Oxide / pharmacology
TL;DR:
High throughput proteomics analysis revealed zinc oxide and poly I:C-specific and combinational patterns that suggested possible utility as an anticancer and immunotherapeutic strategy against melanoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: October 1, 2021
2016 journal article
A new voyage begins: welcoming new editors and the launching of Pharmacokinetic Reports
Journal of Veterinary Pharmacology and Therapeutics, 39, 317.
Source: NC State University Libraries
Added: February 5, 2022
2016 journal article
A physiological based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice
Nanotoxicology, 10, 162–172.
Source: NC State University Libraries
Added: February 5, 2022
2016 journal article
Assessment of penetrant and vehicle mixture properties on transdermal permeability using a mixed effect pharmacokinetic model of ex vivo porcine skin
Biopharmaceutics & Drug Disposition, 37(7), 387–396.
author keywords: quantitative structure property relationship; transdermal permeability; vehicle mixture; ex vivo; mixed-effect model
MeSH headings : Administration, Cutaneous; Animals; Models, Biological; Permeability; Pharmaceutical Preparations / metabolism; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption; Swine
TL;DR:
A mixed effect, pharmacokinetic tissue model was used to model finite dose, transdermal, absorption data from IPPSF experiments for 12 penetrants dosed in up to 10 different vehicles and was able to identify permeability constant, while accounting for between and within unit variability, across the entire data set.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018
2016 journal article
Biological and environmental surface interactions of nanomaterials: characterization, modeling, and prediction
Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 9(3), e1440.
MeSH headings : Animals; Biocompatible Materials; Biomedical Research; Humans; Mice; Models, Theoretical; Molecular Dynamics Simulation; Nanostructures; Structure-Activity Relationship; Surface Properties
TL;DR:
To quantitatively decipher these physicochemical surface interactions, computational methods can be used for either analyses of large amounts of experimental characterization data, or theoretical prediction of the interactions, and consequent biological behavior in the body after administration.
(via Semantic Scholar)
Source: Crossref
Added: September 30, 2021
2016 conference paper
Biological surface adsorption index: environmental applications and parallel molecular dynamics simulations
Proceedings of 8th International Nanotoxicology Conference, 72.
Event: 8th International Nanotoxicology Conference
Source: NC State University Libraries
Added: February 5, 2022
2016 conference paper
Caveats to making in vitro to in vivo and interspecies extrapolations of nanoparticle biological interactions using in silico computational modeling
The 51st Midwest Regional Meeting of the American Chemical Society, 47.
Event: 51st Midwest Regional Meeting of the American Chemical Society at Orlando, FL
Source: NC State University Libraries
Added: February 5, 2022
2016 journal article
Estimation of tulathromycin depletion in plasma and milk after subcutaneous injection in lactating dairy goats using a nonlinear mixed-effect pharmacokinetic modeling approach
BMC Veterinary Research, 12(258).
Source: NC State University Libraries
Added: February 5, 2022
2016 journal article
Exploring Post-Treatment Reversion of Antimicrobial Resistance in Enteric Bacteria of Food Animals as a Resistance Mitigation Strategy
Foodborne Pathogens and Disease, 13(11), 610–617.
author keywords: pre-harvest food safety; antimicrobial use in livestock; antimicrobial resistance in bacteria of animal origin; antimicrobial resistance ecology; population pharmacokinetics
MeSH headings : Animals; Anti-Infective Agents / adverse effects; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / therapeutic use; Drug Residues / standards; Drug Residues / toxicity; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae / drug effects; Enterobacteriaceae / growth & development; Enterobacteriaceae / isolation & purification; Enterobacteriaceae Infections / drug therapy; Enterobacteriaceae Infections / microbiology; Enterobacteriaceae Infections / prevention & control; Enterobacteriaceae Infections / veterinary; Escherichia coli / drug effects; Escherichia coli / growth & development; Escherichia coli / isolation & purification; Escherichia coli Infections / drug therapy; Escherichia coli Infections / microbiology; Escherichia coli Infections / prevention & control; Escherichia coli Infections / veterinary; Evidence-Based Practice; Feces / microbiology; Food Contamination / prevention & control; Food Safety; Foodborne Diseases / drug therapy; Foodborne Diseases / microbiology; Foodborne Diseases / prevention & control; Guidelines as Topic; Humans; Livestock / growth & development; Livestock / microbiology; Secondary Prevention / standards; Tissue Distribution
TL;DR:
It is hypothesize that it is possible to define the distribution of the time period after treatment within which resistance to the administered drug, and possibly other drugs in case of coselection, in fecal bacteria of the treated animals returns to the background pre-treatment levels.
(via Semantic Scholar)
Source: Crossref
Added: October 1, 2021
2016 journal article
Health concerns and management of select veterinary drug residues
Food and Chemical Toxicology, 88, 112–122.
author keywords: Drug; Veterinary; Residue; Adverse; Livestock
MeSH headings : Animals; Carcinogens; Drug Residues / adverse effects; Humans; Veterinary Drugs / chemistry; Veterinary Drugs / metabolism; Veterinary Drugs / pharmacokinetics
TL;DR:
The aim of this manuscript is to review the potential adverse health effects in humans if exposed to residues of selected veterinary drugs used in food-producing animals and how regulatory and independent organizations manage the risk of these veterinary drugs based on data from human health risk assessments.
(via Semantic Scholar)
Sources: Crossref, ORCID
Added: February 24, 2020
2016 journal article
Human food safety implications of variation in food animal drug metabolism
Scientific Reports, 6(27907).
Source: NC State University Libraries
Added: February 5, 2022
2016 journal article
Influence of some plant extracts on the transdermal absorption and penetration of marker residues
Cutaneous and Ocular Toxicology, 30, 1–7.
Source: NC State University Libraries
Added: February 5, 2022
2016 journal article
Limitation of MIC as sole metric of pharmacodynamic response across the range of antimicrobial susceptibility within a single bacterial species
Scientific Reports, 6(37907).
Source: NC State University Libraries
Added: February 5, 2022
2016 journal article
Mathematical modeling and simulation in animal health – Part II : principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment
Journal of Veterinary Pharmacology and Therapeutics, 39(5), 421–438.
MeSH headings : Animals; Food Safety / methods; Models, Statistical; Pharmacokinetics; Veterinary Medicine / methods; Veterinary Medicine / statistics & numerical data
TL;DR:
This review provides a comprehensive summary of PBPK modeling principles, model development methodology, and the current applications in veterinary medicine, with a focus on predictions of drug tissue residues and withdrawal times in food-producing animals.
(via Semantic Scholar)
Source: Crossref
Added: October 1, 2021
2016 journal article
Mechanistic Toxicity Assessment of Hexahydroisohumulone in Canine Hepatocytes, Renal Proximal Tubules, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells
International Journal of Veterinary Health Science & Research, 4(2), 88–103.
TL;DR:
Investigating organ-specific oxidative stress and the molecular mechanism of toxicity using the pathway-focused DNA array of the hop ingredient hexahydroisohumulone with canine hepatocytes, canine proximal tubule cells, bone marrow-derived mesenchymal stem cells and enterocyte-like cells provides insight into genes altered with HEX exposure and the cell-type specific responses in dogs.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 29, 2021
2016 journal article
Mechanistic toxicity assessment of hexahydroisohumulone in canine hepatocytes, renal proximal tubules, and enterocyte like-cells
The Toxicologist, 150, 487.
Source: NC State University Libraries
Added: February 5, 2022
2016 journal article
Modulation of Chemical Dermal Absorption by 14 Natural Products: A Quantitative Structure Permeation (QSPR) Analysis of Components Often Found in Topical Cosmeceuticals
Cutaneous and Ocular Toxicology, 36(3), 237–252.
author keywords: Absorption; compounds of natural origin; mathematical modeling; mixtures; QSPR; skin
MeSH headings : Administration, Topical; Animals; Biological Products / chemistry; Biological Products / pharmacology; Caffeine / chemistry; Caffeine / pharmacokinetics; Cosmetics / chemistry; Cosmetics / pharmacokinetics; Female; In Vitro Techniques; Models, Biological; Permeability; Quantitative Structure-Activity Relationship; Salicylic Acid / chemistry; Salicylic Acid / pharmacokinetics; Skin / metabolism; Skin Absorption / drug effects; Swine
TL;DR:
Modulation of dermal absorption of model components often found in topical preparations by a set of 14 compounds of natural origin using a flow through in vitro porcine skin diffusion system confirms that some natural products incorporated into topical formulations will enhance absorption of other components which could affect their safety and efficacy profiles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: February 5, 2022
2016 journal article
Observations on macrolide resistance in field isolates collected from bovine respiratory disease cases
Veterinary Microbiology, 192, 186–193.
Source: NC State University Libraries
Added: February 5, 2022
2016 journal article
Pharmacokinetics and tissue elimination of flunixin in veal calves
American Journal of Veterinary Research, 77(6), 634–640.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / chemistry; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Cattle / blood; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / chemistry; Clonixin / metabolism; Clonixin / pharmacokinetics; Drug Residues; Half-Life; Liver / chemistry; Muscle, Skeletal / chemistry; Muscle, Skeletal / metabolism
TL;DR:
Results indicated that a slaughter withdrawal interval of several weeks may be necessary to ensure that violative tissue residues of flunixin are not detected in veal calves treated with that drug.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 conference paper
Physiological based pharmacokinetic (PBPK) modeling of nanomaterials: Why is quantitation and anatomical / physiological reality so important?
Proceedings of 8th International Nanotoxicology Conference, 385.
Event: 8th International Nanotoxicology Conference
Source: NC State University Libraries
Added: February 5, 2022
2016 chapter
Potential mechanism of toxicity of hexahydroisohumulone in an in vitro canine model
Presented at the WINNS 2016 – Growing Science in Pet Nutrition.
Event: WINNS 2016 – Growing Science in Pet Nutrition
Source: NC State University Libraries
Added: February 5, 2022
2016 conference paper
Predicting and modeling in vivo nanoparticle biodistribution: caveats to making in vitro and rodent interspecies extrapolations
11th International Particle Toxicology Conference, 54.
Event: 11th International Particle Toxicology Conference
Source: NC State University Libraries
Added: February 5, 2022
2016 journal article
Protein corona modulation of hepatocyte uptake and molecular mechanisms of gold nanoparticle toxicity
Nanotoxicology, 11(1), 64–75.
Contributors: K. Choi*, * & N. Monteiro-Riviere*
author keywords: Gold nanoparticles; human hepatocytes; cell uptake; cytochrome P450; mechanisms of action
MeSH headings : Albumins / chemistry; Blood Proteins / chemistry; Cell Survival / drug effects; Dose-Response Relationship, Drug; Gene Expression Profiling; Gold / chemistry; Gold / metabolism; Gold / toxicity; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Polyethylene Glycols / chemistry; Polyethyleneimine / chemistry; Protein Corona / metabolism; Reactive Oxygen Species / metabolism; Transcriptome / drug effects
TL;DR:
Human hepatic uptake of 40 and 80 nm AuNP with branched polyethylenimine (BPEI), lipoic acid (LA) and polyethylene glycol (PEG) coatings as well as human plasma protein (HP) and human serum albumin (HSA) coronas was investigated to better understanding of the dramatic effect of protein coronas (PC) on AuNP cellular uptake, cytotoxicity and their underlying molecular mechanisms of action.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 27, 2021
2016 journal article
Protocol for diversion of confirmed positive bulk raw milk tankers to calf ranches – A review of the Pharmacokinetics of tetracyclines and sulfonamides in veal calves
Animal Health Research Reviews, 17(2), 127–136.
author keywords: tetracycline; chlortetracycline; oxytetracycline; sulfonamide; veal; residue; discard milk
MeSH headings : Animals; Anti-Bacterial Agents; Cattle / metabolism; Drug Residues; Milk / chemistry; Sulfonamides / pharmacokinetics; Tetracyclines / chemistry; Tetracyclines / pharmacokinetics
TL;DR:
The suggested withdrawal interval of 20 days will ensure that no veal calves will test positive for residues from being fed this milk, and will provide a residue avoidance strategy for TTC and sulfonamide residues in veal.
(via Semantic Scholar)
Source: Crossref
Added: October 1, 2021
2016 journal article
Quantification of nanoparticle pesticide adsorption: computational approaches based on experimental data
Nanotoxicology, 10(8), 1118–1128.
Contributors: R. Chen *, Y. Zhang *, N. Monteiro-Riviere* & *
author keywords: BSAI; in situ characterization; nanoparticles; pesticide; surface physicochemistry
MeSH headings : Adsorption; Models, Theoretical; Nanoparticles / analysis; Nanoparticles / chemistry; Neural Networks, Computer; Pesticides / analysis; Pesticides / chemistry; Principal Component Analysis; Surface Properties
TL;DR:
The first attempt of the application of such quantitative measures toward environmental endpoints by analyzing the interactions of a selected group of nanomaterials with a variety of pesticides was made and quantitative computational approaches support theApplication of BSAI modeling in the area of environmental contamINANt detection and remediation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2016 journal article
Residue concerns following exposure to livestock to oil and petroleum products
Journal of the American Veterinary Medical Association, 248, 145–146.
Source: NC State University Libraries
Added: February 5, 2022
2016 chapter
The effects of vehicle mixtures on transdermal absorption: thermodynamics, mechanism, assessment and prediction
In N. Dragicevic-Curic & H. I. Maibach (Eds.), Percutaneous Penetration Enhancers Drug Penetration Into/Through the Skin: Methodology and General Considerations (pp. 95–118). New York: Springer.
Ed(s): N. Dragicevic-Curic & H. Maibach
Source: NC State University Libraries
Added: February 5, 2022
2015 journal article
A Framework for Meta-Analysis of Veterinary Drug Pharmacokinetic Data Using Mixed Effect Modeling
Journal of Pharmaceutical Sciences, 104(4), 1230–1239.
author keywords: meta-analysis; nonlinear mixed-effect modeling; pharmacokinetics; population pharmacokinetics; veterinary medicine; drug depletion; drug withdrawal time; clearance; distribution; formulation
MeSH headings : Animals; Computer Simulation; Data Mining; Databases, Factual; Humans; Meta-Analysis as Topic; Models, Biological; Models, Statistical; Nonlinear Dynamics; Reproducibility of Results; Species Specificity; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
The overriding strength of meta-analysis applied to this field is that robust statistical analysis of the diverse sparse data sets inherent to veterinary medicine applications can be accomplished, thereby allowing population inferences to be made.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
Source: Crossref
Added: December 24, 2021
2015 journal article
A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles
Nanomedicine, 11(2), 107–119.
Contributors: Z. Lin *, N. Monteiro-Riviere* , R. Kannan * & *
author keywords: biodistribution; computational nanotoxicology; endocytosis; nanomaterials; PBPK modeling; physiologically based pharmacokinetic modeling; phagocytosis; toxicokinetics
MeSH headings : Animals; Cell Survival / drug effects; Computer Simulation; Dose-Response Relationship, Drug; Environmental Exposure / adverse effects; Gold / pharmacokinetics; Gold / toxicity; Humans; Metabolic Clearance Rate; Mice; Models, Biological; Nanoparticles / toxicity; Rats; Species Specificity; Swine; Tissue Distribution; Toxicity Tests / methods
TL;DR:
These results partially explain the current low translation rate of nanotechnology-based drug delivery systems from mice to humans and may be applied to other nanomaterials and provides guidance to design future translational studies.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID, NC State University Libraries
Added: April 29, 2021
2015 journal article
Canine renal proximal tubule cells as an in vitro model for toxicity assessment of pet food ingredients
The Toxicologist, 144, 490.
Source: NC State University Libraries
Added: February 5, 2022
2015 journal article
Comparative In Vitro Cytotoxicity of 20 Potential Food Ingredients in Canine Liver, Kidney, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells
Applied In Vitro Toxicology, 1(4), 276–288.
TL;DR:
Dose–response cytotoxicity studies and LC50 using alamar blue assays are reported for seven additional compounds: denatonium benzoate, eucalyptol, hexahydro isohumulone, tetrahydroisohumULone, green tea catechin extract, epigallocatechin gallate, and sodium copper chlorophyllin.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, NC State University Libraries
Added: April 30, 2021
2015 journal article
Determination of thermodynamic solubility of active pharmaceutical ingredients for veterinary species: a new USP general chapter
Pharmacopeial Forum, 41(3).
Source: NC State University Libraries
Added: February 5, 2022
2015 conference paper
Development of a physiologically-relevant multivariate nanoparticle molecular interaction fingerprint
Presented at the 250th American Chemical Society National Meeting, Boston, MA.
Event: 250th American Chemical Society National Meeting at Boston, MA
Source: NC State University Libraries
Added: February 5, 2022
2015 journal article
Differential effects of some natural compounds on the transdermal absorption and penetration of caffeine and salicylic acid
International Journal of Pharmaceutics, 483(1-2), 151–157.
author keywords: Natural substance; Skin; Penetration; Drugs
MeSH headings : Animals; Biological Products / chemistry; Biological Products / pharmacology; Caffeine / chemistry; Caffeine / pharmacokinetics; Carbon Radioisotopes; Diffusion; Dose-Response Relationship, Drug; Female; Molecular Structure; Permeability / drug effects; Salicylic Acid / chemistry; Salicylic Acid / pharmacokinetics; Skin Absorption / drug effects; Structure-Activity Relationship; Swine
TL;DR:
The results emphasize the differential effects of natural substances on the transdermal penetration of hydrophilic (caffeine) and hydrophobic (salicylic acid) drugs.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 24, 2021
2015 journal article
Egg residue considerations during the treatment of backyard poultry
Journal of the American Veterinary Medical Association, 247(12), 1388–1395.
MeSH headings : Animal Feed; Animal Husbandry; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Chickens; Drug Residues; Eggs / analysis; Poultry Diseases / drug therapy; Turkeys; United States; United States Food and Drug Administration
TL;DR:
The purpose of this digest was to provide US veterinarians guidance on the responsible treatment of backyard poultry flocks and information regarding the depletion of drug residues in eggs from hens treated with various drugs in an extralabel manner is sparse or lacking.
(via Semantic Scholar)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Estimation of residue depletion of cyadox and its marker residue in edible tissues of pigs using physiologically based pharmacokinetic modeling
Food Additives & Contaminants: Part A, 32(12), 2002–2017.
author keywords: cyadox; 1,4-bisdesoxycyadox; PBPK modelling; tissue depletion; residue prediction; sensitivity analysis; Monte Carlo analysis
MeSH headings : Adipose Tissue / chemistry; Adipose Tissue / metabolism; Animal Feed / analysis; Animals; Anti-Infective Agents / isolation & purification; Anti-Infective Agents / metabolism; Anti-Infective Agents / pharmacokinetics; Biotransformation; Chromatography, Liquid; Drug Residues / isolation & purification; Drug Residues / metabolism; Food Analysis / methods; Kidney / chemistry; Kidney / metabolism; Liver / chemistry; Liver / metabolism; Models, Statistical; Monte Carlo Method; Muscle, Skeletal / chemistry; Muscle, Skeletal / metabolism; Quinoxalines / isolation & purification; Quinoxalines / metabolism; Quinoxalines / pharmacokinetics; Swine; Tandem Mass Spectrometry; Veterinary Drugs / isolation & purification; Veterinary Drugs / metabolism; Veterinary Drugs / pharmacokinetics
TL;DR:
A PBPK model was developed to simultaneously describe the depletion in pigs of the food animal antimicrobial agent cyadox, and its marker residue 1,4-bisdesoxycyadox (BDCYA).
(via Semantic Scholar)
Source: Web Of Science
Added: February 5, 2022
2015 journal article
Excretory, Secretory, and Tissue Residues after Label and Extra-label Administration of Flunixin Meglumine to Saline- or Lipopolysaccharide-Exposed Dairy Cows
Journal of Agricultural and Food Chemistry, 63(19), 4893–4901.
author keywords: dairy; extra-label; flunixin; holstein; liver; metabolite ratio; milk; residue
MeSH headings : Adipose Tissue / chemistry; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / analysis; Clonixin / pharmacokinetics; Drug Labeling; Drug Residues / analysis; Drug Residues / pharmacokinetics; Female; Inflammation / chemically induced; Inflammation / drug therapy; Kidney / chemistry; Lipopolysaccharides / adverse effects; Liver / chemistry; Milk / chemistry; Muscle, Skeletal / chemistry; Sodium Chloride / administration & dosage; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
Flunixin meglumine administered by either intravenous infusion or intramuscular injection at 24 h intervals may be related to LPS inhibition of flunixIn metabolism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 conference paper
Flunixin urine residues in culled dairy cows and its relevance to food safety and environmental concern
Presented at the 250th American Chemical Society National Meeting, Boston, MA.
Event: 250th American Chemical Society National Meeting at Boston, MA
Source: NC State University Libraries
Added: February 5, 2022
2015 journal article
Gold and silver nanoparticle interactions with human proteins: impact and implications in biocorona formation
Journal of Materials Chemistry B, 3(10), 2075–2082.
Contributors: A. Sasidharan *, * & N. Monteiro-Riviere*
TL;DR:
Findings suggest that irrespective of NP surface chemistry or chemical composition, corona proteins at their physiological concentrations interact rather differently; wherein HSA and IgG coronas adsorbed strongly on the NP surface and kept both Au and AgNP well dispersed, while fibrinogen caused rapid, strong and irreversible agglomeration.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID, NC State University Libraries
Added: May 3, 2021
2015 journal article
Interaction of silver and gold nanoparticles with protein biocorona formation and its impact on cellular toxicity
International Journal of Toxicology, 34, 78–79.
Source: NC State University Libraries
Added: February 5, 2022
2015 journal article
Mathematical modeling and simulation in animal health. Part I: Moving beyond pharmacokinetics
Journal of Veterinary Pharmacology and Therapeutics, 39(3), 213–223.
MeSH headings : Animals; Computer Simulation; Models, Biological; Veterinary Drugs / pharmacokinetics
TL;DR:
Concepts and approaches to modeling and simulation based on solid physiological and pharmacological principles as well as adhering to the limitations that are fundamental to applying mathematical and statistical models to biological systems are introduced.
(via Semantic Scholar)
Source: Crossref
Added: October 1, 2021
2015 journal article
Nanoparticle surface characterization and clustering through concentration-dependent surface adsorption modeling
The Toxicologist, 144, 66.
Source: NC State University Libraries
Added: February 5, 2022
2015 journal article
Oxidative stress response in canine in vitro liver, kidney and intestinal models with seven potential dietary ingredients
Toxicology Letters, 241, 49–59.
Contributors: K. Choi*, M. Ortega*, B. Jeffery, * & N. Monteiro-Riviere*
author keywords: In vitro canine culture systems; Multiple organ-derived cells; Dietary ingredients; Organ-specific oxidative stress
MeSH headings : Animals; Antioxidants / chemistry; Antioxidants / pharmacology; Bone Marrow Cells / drug effects; Bone Marrow Cells / metabolism; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Food; Food Analysis; Hepatocytes / drug effects; Intestinal Mucosa / metabolism; Intestines / drug effects; Kidney / drug effects; Kidney / metabolism; Kidney Tubules, Proximal / cytology; Kidney Tubules, Proximal / drug effects; Liver / drug effects; Liver / metabolism; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Oxidants / toxicity; Oxidative Stress / drug effects
TL;DR:
The results suggest that organ-specific responses to oxidative stress by these potential prooxidant compounds may implicate a mechanism of their toxicities.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2015 journal article
Pharmacokinetics and pharmacodynamics of gamithromycin in pulmonary epithelial lining fluid in naturally occurring bovine respiratory disease in multisource commingled feedlot cattle
Journal of Veterinary Pharmacology and Therapeutics, 39(2), 157–166.
MeSH headings : Animals; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / therapeutic use; Area Under Curve; Body Fluids / chemistry; Body Fluids / metabolism; Bovine Respiratory Disease Complex / drug therapy; Bovine Respiratory Disease Complex / metabolism; Cattle; Epithelium / chemistry; Epithelium / metabolism; Lung; Macrolides / metabolism; Macrolides / pharmacokinetics; Macrolides / therapeutic use; Microbial Sensitivity Tests; Models, Biological
TL;DR:
Findings indicate that higher PK/PD indices were predictive of positive treatment outcomes in feeder cattle diagnosed with bovine respiratory disease and treated with gamithromycin at the label dose.
(via Semantic Scholar)
Sources: Crossref, Web Of Science
Added: October 2, 2021
2015 journal article
Predicting Adsorption Affinities of Small Molecules on Carbon Nanotubes Using Molecular Dynamics Simulation
ACS Nano, 9(12), 11761–11774.
author keywords: nanoparticles; free-energy calculations; surface physicochemistry; virtual screening; benzene derivatives; graphene; surface functionalization; aromatic
TL;DR:
The authors' simulations suggest that polyvinylpyrrolidone conjugation gives the highest affinity for atrazine-substantially greater than that of graphenic carbon alone-and may be useful as a nanomaterial for delivery or sequestration of atrazin.
(via Semantic Scholar)
Source: Crossref
Added: December 24, 2021
2015 journal article
Prediction and comparison of size-dependent biodistribution of polyethylene glycol-coated gold nanoparticles in adult mice: a physiologically based pharmacokinetic model
The Toxicologist, 144, 65.
Source: NC State University Libraries
Added: February 5, 2022
2015 journal article
Quantification of vehicle mixture effects on in vitro transdermal chemical flux using a random process diffusion model
Journal of Controlled Release, 217, 74–81.
author keywords: Transdermal absorption; Chemical mixture; QSPR; Skin permeability; Mathematical modeling; In vitro model
MeSH headings : 1-Octanol / chemistry; Animals; Diffusion; Models, Biological; Molecular Weight; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / metabolism; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption; Swine; Water / chemistry
TL;DR:
This analysis improved on previous work, finding a more parsimonious model with higher predictability, while still identifying the mixture refractive index as a key descriptor in predicting vehicle effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018
2015 journal article
Safety assessment of pet food ingredients using cryopreserved canine hepatocytes-based in vitro assays
The Toxicologist, 144, 20.
Source: NC State University Libraries
Added: February 5, 2022
2015 journal article
Safety assessment of potential food ingredients in canine hepatocytes
Food and Chemical Toxicology, 78, 105–115.
Contributors: L. Zhang *, J. Koci *, B. Jeffery, * & N. Monteiro-Riviere*
MeSH headings : Acetaminophen / toxicity; Acrolein / analogs & derivatives; Acrolein / toxicity; Aflatoxin B1 / toxicity; Animal Feed / standards; Animals; Cell Line; Cell Survival / drug effects; Dogs; Down-Regulation; Eugenol / toxicity; Food Analysis; Food Safety; Ginger / chemistry; Ginger / toxicity; Hepatocytes / drug effects; Hepatocytes / metabolism; Humans; Lethal Dose 50; Oils, Volatile / toxicity; Plant Extracts / toxicity; Plant Oils / toxicity; Plant Roots / chemistry; Plant Roots / toxicity; Rats; Terpenes / toxicity; Thymol / toxicity; Up-Regulation; Xylitol / toxicity
TL;DR:
In vitro assays such as this may be useful for hazard assessment of food ingredients for altered hepatic function, which CYP and heat shock most affected.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021
2015 journal article
Screening and Confirmatory Analyses of Flunixin in Tissues and Bodily Fluids after Intravenous or Intramuscular Administration to Cull Dairy Cows with or without Lipopolysaccharide Challenge
Journal of Agricultural and Food Chemistry, 64(1), 336–345.
author keywords: flunixin; ELISA; route of administration; concentration; food safety
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Cattle Diseases / blood; Cattle Diseases / drug therapy; Cattle Diseases / metabolism; Cattle Diseases / urine; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Drug Residues / pharmacokinetics; Female; Injections, Intramuscular; Kidney / chemistry; Kidney / metabolism; Liver / chemistry; Liver / metabolism; Milk / chemistry; Muscles / chemistry; Muscles / metabolism; Tissue Distribution
TL;DR:
The ratio of urinary flunixin and 5-hydroxy flunxin may be useful for predicting disruption of metabolism caused by disease or other factors potentially leading to violative liver and milk violative residues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Toxicokinetic approaches to improving accuracy of drug withdrawal times in food producing animals to avoid toxic violative tissue residues
International Journal of Toxicology, 34, 78.
Source: NC State University Libraries
Added: February 5, 2022
2015 journal article
Toxicological effects of pet food ingredients on canine bone marrow-derived mesenchymal stem cells and enterocyte-like cells
Journal of Applied Toxicology, 36(2), 189–198.
Contributors: M. Ortega*, B. Jeffery, * & N. Monteiro-Riviere*
author keywords: canine; bone marrow stem cells; enterocyte like cells; adult stem cell differentiation; essential oils; cytotoxicity; mesenchymal stem cells; in vitro
MeSH headings : Acrolein / analogs & derivatives; Acrolein / toxicity; Animal Feed / toxicity; Animals; Bone Marrow / drug effects; Citric Acid / toxicity; Clove Oil / toxicity; Cytotoxins / toxicity; Dogs; Enterocytes / drug effects; Eugenol / toxicity; Ginger / toxicity; Guanosine Monophosphate / toxicity; Inosine Monophosphate / toxicity; Mesenchymal Stem Cells / drug effects; Oils, Volatile / toxicity; Pets; Plant Oils / toxicity; Plant Roots / toxicity; Sorbose / toxicity; Thymol / toxicity
TL;DR:
These studies provide a baseline against which differential toxicity of dietary feed ingredients can be assessed in vitro for direct effects on canine cells and demonstrate differential toxicity in differentiated cells that represent gastrointestinal epithelial cells.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 29, 2021
2014 journal article
A pharmacokinetic modeling framework for interspecies extrapolation of nanoparticle biodistribution taking into account biocorona dynamics independent of species-specific disposition processes
Toxicologist, 138, 211.
Source: NC State University Libraries
Added: May 21, 2022
2014 journal article
Antimicrobial Agents in Veterinary Medicine
Journal of Veterinary Pharmacology and Therapeutics, 37(1), 1–1.
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bacteria / drug effects; Bacterial Infections / drug therapy; Bacterial Infections / veterinary; Drug Resistance, Bacterial; Drug Utilization / standards
Source: Crossref
Added: December 24, 2021
2014 conference paper
Canine renal proximal tubule cells as an in vitro model for toxicity assessment of pet food ingredients
Central States Society of Toxicology Annual Meeting, 49.
Source: NC State University Libraries
Added: May 27, 2022
2014 journal article
Comparison of pharmacokinetics and milk elimination of flunixin in healthy cows and cows with mastitis
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 246(1), 118–125.
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Cephalosporins / therapeutic use; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Female; Mastitis, Bovine / drug therapy; Mastitis, Bovine / metabolism; Milk / chemistry
TL;DR:
Pharmacokinetics and elimination of flunixin and 5-hydroxy flunxin in milk differed between mastitic and healthy cows, resulting in violative residues, which may partially explain the high number of fl unixin residues reported in beef and dairy cattle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 chapter
Dermal Exposure and Absorption of Chemicals and Nanomaterials
In Reference Module in Biomedical Sciences.
Sources: Crossref, NC State University Libraries
Added: May 30, 2021
2014 chapter
Dermatoxicity of nanomaterials
In B. Fadeel (Ed.), Handbook of Safety Assessment of Nanomaterials: From Toxicology Testing to Personalized Medicine (pp. 439–459). Singapore: Pan Stanford.
Ed(s): B. Fadeel
Source: NC State University Libraries
Added: May 27, 2022
2014 journal article
Development and Application of a Multiroute Physiologically Based Pharmacokinetic Model for Oxytetracycline in Dogs and Humans
Journal of Pharmaceutical Sciences, 104(1), 233–243.
author keywords: oxytetracycline; physiologically based pharmacokinetic (PBPK) modeling; dogs; tetracycline antibiotics; Food Animal Residue Avoidance Databank (FARAD); computational ADME; mathematical model; pharmacokinetics; in silico modeling; disposition
MeSH headings : Administration, Oral; Animals; Animals, Inbred Strains; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Computational Biology; Computer Simulation; Databases, Pharmaceutical; Dogs; Dose-Response Relationship, Drug; Humans; Injections, Intramuscular; Injections, Intravenous; Kidney / metabolism; Models, Biological; Oxytetracycline / administration & dosage; Oxytetracycline / blood; Oxytetracycline / metabolism; Oxytetracycline / pharmacokinetics; Pharmacology, Clinical / methods; Physiology, Comparative / methods; Renal Elimination; Reproducibility of Results; Species Specificity; Tissue Distribution; Veterinary Medicine / methods
TL;DR:
A permeability-limited multiroute physiologically based pharmacokinetic model developed in dogs can be used to predict plasma and tissue concentrations to aid in designing optimal therapeutic regimens with OTC in veterinary, and potentially, human medicine; and as a foundation for scaling to other tetracycline antibiotics and to other animal species.
(via Semantic Scholar)
Source: Crossref
Added: October 1, 2021
2014 journal article
Development of a Mixed-Effect Pharmacokinetic Model for Vehicle Modulated In Vitro Transdermal Flux of Topically Applied Penetrants
JOURNAL OF PHARMACEUTICAL SCIENCES, 103(3), 1002–1012.
author keywords: transdermal drug delivery; skin; passive diffusion; transport; mathematical model; in vitro models; formulation vehicle; diffusion
MeSH headings : Administration, Cutaneous; Algorithms; Animals; Diffusion; Dimethylpolysiloxanes / chemistry; In Vitro Techniques; Models, Biological; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / analysis; Pharmaceutical Preparations / chemistry; Pharmaceutical Vehicles / chemistry; Pharmacokinetics; Reproducibility of Results; Skin Absorption; Sus scrofa
TL;DR:
A mixed effects modeling framework was used so that models can be estimated with as few parameters as possible, while also quantifying variability and accounting for correlation in the data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus)
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 31(9), 1506–1521.
author keywords: flunixin; PBPK models; withdrawal intervals; route of administration; cattle (Bos taurus)
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle / blood; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Drug Residues; Liver / chemistry; Liver / metabolism; Milk / chemistry; Models, Biological; Sensitivity and Specificity; Software; Uncertainty
TL;DR:
A physiologically based pharmacokinetic (PBPK) model was developed to predict plasma, liver and milk concentrations of flunixin in cattle following intravenous, intramuscular or subcutaneous administration for use as a tool to determine factors that may affect the withdrawal time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 conference paper
Differential effects of some natural compounds on the transdermal penetration of caffeine and salicylic acid
Central States Society of Toxicology Annual Meeting, 52.
Source: NC State University Libraries
Added: May 27, 2022
2014 conference paper
Impact and implications of gold nanoparticle interactions with human serum proteins and biocorona formation
Central States Society of Toxicology Annual Meeting, 19.
Source: NC State University Libraries
Added: May 27, 2022
2014 chapter
Importance of veterinary drug residues
In R. Baynes & J. E. Riviere (Eds.), Strategies for Reducing Drug and Chemical Residues in Food Animals: International Approaches to Residue Avoidance, Management and Testing (pp. 1–8,). New York: Wiley.
Ed(s): R. Baynes &
Source: NC State University Libraries
Added: May 21, 2022
2014 journal article
In silico models to predict dermal absorption from complex agrochemical formulations
SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 25(7), 565–588.
author keywords: dermal absorption; mixture; quantitative structure permeability relationship (QSPR); risk assessment; agrochemicals
MeSH headings : Agrochemicals / pharmacokinetics; Animals; Complex Mixtures / pharmacokinetics; Computer Simulation; Humans; Linear Models; Models, Biological; Quantitative Structure-Activity Relationship; Rats; Skin / metabolism; Skin Absorption
TL;DR:
Application of this in silico prediction model would reduce animal and non-animal testings when used for the optimization of formulations in early developmental stages, or would simplify the registration process, if accepted for read-across.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
In silico models to predict dermal absorption from complex agrochemical formulations
SAR and QSAR in Environmental Research, 6, 1–24.
Source: NC State University Libraries
Added: February 5, 2022
2014 journal article
In vitro safety assessment of food ingredients in canine renal proximal tubule cells
Toxicology in Vitro, 29(2), 289–298.
Contributors: J. Koči *, B. Jeffery, * & N. Monteiro-Riviere*
author keywords: Food ingredients; Canine; Proximal tubule cells; Lemongrass oil; Gene expression; Metabolic pathway
MeSH headings : Acrolein / analogs & derivatives; Acrolein / toxicity; Aminophenols / toxicity; Animals; Cell Survival / drug effects; Citric Acid / toxicity; Dogs; Eugenol / toxicity; Food Safety; Gene Expression Profiling; Ginger; Guanosine Monophosphate / toxicity; Humans; Inosine Monophosphate / toxicity; Kidney Tubules, Proximal / cytology; Oils, Volatile / toxicity; Plant Extracts / toxicity; Plant Oils / toxicity; Plant Roots; Sorbose / toxicity; Terpenes / toxicity; Thymol / toxicity; Thymus Plant; Toxicity Tests / methods; Xylitol / toxicity
TL;DR:
Viability assays along with mechanistic studies in the CPTC model may serve as a valuable in vitro toxicity screening tool.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: May 3, 2021
2014 journal article
In vitro safety assessment of pet food ingredients on canine primary renal tubule cell lines
Toxicologist, 138, 81.
Source: NC State University Libraries
Added: May 21, 2022
2014 journal article
Interspecies Mixed-Effect Pharmacokinetic Modeling of Penicillin G in Cattle and Swine
Antimicrobial Agents and Chemotherapy, 58(8), 4495–4503.
MeSH headings : Age Factors; Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Body Weight; Cattle; Humans; Injections, Intramuscular; Injections, Intravenous; Kidney / chemistry; Kidney / metabolism; Liver / chemistry; Liver / metabolism; Meat / analysis; Models, Statistical; Muscle, Skeletal / chemistry; Muscle, Skeletal / metabolism; Penicillin G / blood; Penicillin G / pharmacokinetics; Species Specificity; Swine
TL;DR:
This study established a robust model of penicillin for a large and diverse population of food-producing animals which could be applied to other antibiotics and species in future analyses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Interspecies allometric meta-analysis of the comparative pharmacokinetics of 85 drugs across veterinary and laboratory animal species
Journal of Veterinary Pharmacology and Therapeutics, 38(3), 214–226.
Event: American Conference on Pharmacometrics at Las Vegas, NV
MeSH headings : Animals; Humans; Species Specificity; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
The results showed that 77% and 88% of drugs displayed significant correlations between total systemic clearance (CL) and volume of distribution at steady status (Vss) vs. body weight (P < 0.05) on a log-log scale, respectively.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: December 24, 2021
2014 conference paper
Interspecies and in vitro / in vivo extrapolation of nanoparticle biodistribution involving protein corona formation
Proceedings of the 7th International Nanotoxicology Conference, 31.
Event: 7th International Nanotoxicology Conference at Antalya, Turkey
Source: NC State University Libraries
Added: May 21, 2022
2014 journal article
Nanoparticle Surface Characterization and Clustering through Concentration-Dependent Surface Adsorption Modeling
ACS Nano, 8(9), 9446–9456.
Contributors: R. Chen, Y. Zhang, F. Darabi Sahneh, C. Scoglio, W. Wohlleben *, A. Haase *, N. Monteiro-Riviere* , *
author keywords: BSAI; nanoparticles; nanomedicine; nanotoxicology surface physicochemistry; in situ characterization
MeSH headings : Adsorption; Models, Molecular; Nanoparticles / chemistry; Surface Properties
TL;DR:
The approach beyond the application of five descriptors in the original BSAI to address the concentration dependence of the descriptors, enabling better prediction of the adsorption profile and more accurate categorization of nanomaterials based on their surface properties is advanced.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: June 12, 2021
2014 conference paper
Nanoparticle surface characterization and clustering through concentration-dependent surface adsorption modeling
Central States Society of Toxicology Annual Meeting, 46.
Source: NC State University Libraries
Added: May 27, 2022
2014 chapter
Pharmacokinetics and biodistribution of nanomaterials
In N. A. Monteiro-Riviere & C. L. Tran (Eds.), Nanotoxicology (2nd ed., pp. 135–152). New York: Informa.
Ed(s): N. Monteiro-Riviere & C. Tran
Source: NC State University Libraries
Added: May 27, 2022
2014 conference paper
Pharmacokinetics and pharmacodynamics of gamithromycin in pulmonary epithelial lining fluid 9PLF) in naturally occurring bovine respiratory disease in multi-sourced commingled feedlot cattle
Presented at the 7th International Conference on Antimicrobial Agents in Veterinary Medicine, Berlin, Germany.
Event: 7th International Conference on Antimicrobial Agents in Veterinary Medicine at Berlin, Germany
Source: NC State University Libraries
Added: May 21, 2022
2014 journal article
Pharmacokinetics of metallic nanoparticles
WIREs Nanomedicine and Nanobiotechnology, 7(2), 189–217.
Contributors: Z. Lin *, N. Monteiro-Riviere* & *
MeSH headings : Animals; Humans; Metal Nanoparticles / chemistry; Models, Biological; Pharmacokinetics
TL;DR:
Physiologically based pharmacokinetic models for gold/dendrimer composite nanodevices, AgNPs, and TiO2 NP models have been developed in rats and extrapolated to humans to support risk assessment and nanomedicine applications.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021
2014 journal article
Pharmacokinetics, tissue distribution, and excretion of nomegestrol acetate in female rats
European Journal of Drug Metabolism and Pharmacokinetics, 40(4), 435–442.
author keywords: Nomegestrol acetate; NOMAC; Pharmacokinetics; Tissue distribution; Excretion; HPLC
MeSH headings : Animals; Bile / drug effects; Bile / metabolism; Feces; Female; Liver / drug effects; Liver / metabolism; Megestrol / pharmacokinetics; Megestrol / urine; Norpregnadienes / pharmacokinetics; Norpregnadienes / urine; Rats; Rats, Sprague-Dawley; Tissue Distribution / drug effects; Tissue Distribution / physiology
TL;DR:
NOMAC had a widespread distribution in tissues, including ovary, pituitary, and hypothalamus, which are main target tissues where NOMAC inhibits ovulation.
(via Semantic Scholar)
Source: Crossref
Added: December 24, 2021
2014 chapter
Physiologically based nanomaterial pharmacokinetic (PBNK) models
In B. Fadeel (Ed.), Handbook of Safety Assessment of Nanomaterials: From Toxicology Testing to Personalized Medicine (pp. 243–264). Singapore: Pan Stanford.
Ed(s): B. Fadeel
Source: NC State University Libraries
Added: May 27, 2022
2014 journal article
Predicting the impact of biocorona formation kinetics on interspecies extrapolations of nanoparticle biodistribution modeling
Nanomedicine, 10(1), 25–33.
Contributors: F. Sahneh *, C. Scoglio *, N. Monteiro-Riviere* & *
author keywords: allometry; biocorona; interspecies extrapolation; in vitro-in vivo correlation; nanomaterials; nanoparticle biodistribution
MeSH headings : Animals; Humans; Kinetics; Mice; Models, Theoretical; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Pharmacokinetics; Rats; Surface Properties; Tissue Distribution
TL;DR:
While engineered NPs can successfully reach target cells in rodent models, the results may be different in humans due to the fact that the longer circulation time allows for further biocorona evolution.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: April 30, 2021
2014 conference paper
Prediction and comparison of size-dependent biodistribution of polyethylene glycol-coated gold nanoparticles in adult mice: a physiologically based pharmacokinetic model
Central States Society of Toxicology Annual Meeting, 50.
Source: NC State University Libraries
Added: May 27, 2022
2014 journal article
Prediction of formulation effects on dermal absorption of topically applied ectoparasiticides dosed in vitro on canine and porcine skin using a mixture-adjusted quantitative structure permeability relationship
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 37(5), 435–444.
MeSH headings : Administration, Topical; Animals; Chemical Phenomena; Dogs; Insecticides / pharmacokinetics; Models, Biological; Permeability; Skin / drug effects; Skin Absorption / physiology; Swine; Tissue Culture Techniques
TL;DR:
These studies clearly showed that the permeation of topical ectoparasiticides could be well predicted using QSPeR models that account for both the physical-chemical properties of the penetrant and formulation components.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 chapter
Risk management of chemical contaminants in livestock
In R. Baynes & J. E. Riviere (Eds.), Strategies for Reducing Drug and Chemical Residues in Food Animals: International Approaches to Residue Avoidance, Management and Testing (pp. 303–312). New York: Wiley.
Ed(s): R. Baynes &
Source: NC State University Libraries
Added: May 21, 2022
2014 conference paper
Safety assessment of pet food ingredients using cryopreserved canine hepatocytes-based in vitro assays
Central States Society of Toxicology, 47.
Event: Central States Society of Toxicology
Source: NC State University Libraries
Added: May 21, 2022
2014 journal article
Safety assessment of potential food ingredients on canine primary hepatocytes
Toxicologist, 138, 420.
Source: NC State University Libraries
Added: May 21, 2022
2014 conference paper
Silver and gold metal nanoparticle-protein interactions: Role of physiochemical properties
Proceedings of the 7th International Nanotoxicology Conference, 245–246.
Event: 7th International Nanotoxicology Conference at Antalya, Turkey
Source: NC State University Libraries
Added: May 21, 2022
2014 chapter
The Food Animal Residue Avoidance databank: An example of risk management of veterinary drug residues
In R. Baynes & J. E. Riviere (Eds.), Strategies for Reducing Drug and Chemical Residues in Food Animals: International Approaches to Residue Avoidance, Management and Testing (pp. 289–302). New York: Wiley.
Ed(s): R. Baynes &
Source: NC State University Libraries
Added: May 21, 2022
2014 journal article
The application of allometric scaling principles to predict pharmacokinetic parameters across species
Expert Opinion on Drug Metabolism & Toxicology, 10(9), 1241–1253.
author keywords: allometric scaling; clearance; comparative pharmacology; elimination half-life; interspecies pharmacokinetics; veterinary medicine; volume of distribution
MeSH headings : Animals; Dose-Response Relationship, Drug; Humans; Models, Theoretical; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Pharmacokinetics; Species Specificity; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
Although interspecies allometric scaling needs further refinements and has limitations, it is still a potential tool and rational option for the estimate of pharmacokinetic parameters in species for which there are no data available or to better interpret preclinical efficacy and safety trials.
(via Semantic Scholar)
Source: Crossref
Added: December 24, 2021
2014 conference paper
Toxicological effect of a pet food ingredient on canine bone marrow derived mesenchymal stem cells and enterocyte-like cells
Central States Society of Toxicology Annual Meeting, 53.
Source: NC State University Libraries
Added: May 27, 2022
2014 journal article
Understanding the dynamic behavior of the protein corona and its influence on the physiochemical composition of silver nanoparticles
Toxicologist, 138, 211.
Source: NC State University Libraries
Added: May 21, 2022
2013 journal article
A dynamically integrative PKPD model to predict the efficacy of marbofloxacin treatment regimen for bovine Manheima hemolytica infection
PAGE, 22, 153,
Source: NC State University Libraries
Added: July 29, 2022
2013 journal article
Animal Health Modeling and Simulation Society (AHM&S): A new society promoting model-based approaches for a better integration and understanding of quantitative pharmacology in veterinary science
PAGE, 22, 143,
Source: NC State University Libraries
Added: June 17, 2022
2013 journal article
Animal Health Modeling and Simulation Society (AHM&S): A new society promoting model-based approaches in veterinary pharmacology
Journal of Veterinary Pharmacology and Therapeutics, 36, 417–419.
Source: NC State University Libraries
Added: May 27, 2022
2013 journal article
Assessing vehicle effects on skin absorption of non-volatile compounds using membrane-coated fiber arrays
Cutaneous and Ocular Toxicology, 32(4), 283–289.
author keywords: Absorption; chemical mixtures; membrane-coated fiber; skin
MeSH headings : Acrylic Resins / chemistry; Caffeine / chemistry; Cortisone / chemistry; Diclofenac / chemistry; Dimethylpolysiloxanes / chemistry; Ethanol / chemistry; Mannitol / chemistry; Membranes, Artificial; Polyethylene Glycols / chemistry; Salicylic Acid / chemistry; Skin Absorption; Testosterone / chemistry; Volatilization; Water / chemistry
TL;DR:
The MCF array is not suitable to describe the vehicle effects on skin absorption of non-volatile compounds, and its potential use as a formulation screening technique is disputes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: December 24, 2021
2013 journal article
Assessing vehicle effects on skin absorption using artificial membrane assays
European Journal of Pharmaceutical Sciences, 50(5), 569–576.
author keywords: Skin; Parallel artificial membrane permeability assays (PAMPAS); Isopropyl myristate; Certramides; Strat-M (TM); Dermal/percutaneous absorption
MeSH headings : Animals; Biological Assay; Caffeine / chemistry; Caffeine / metabolism; Cortisone / chemistry; Cortisone / metabolism; Diclofenac / chemistry; Diclofenac / metabolism; Ethanol / chemistry; In Vitro Techniques; Mannitol / chemistry; Mannitol / metabolism; Membranes, Artificial; Propylene Glycol / chemistry; Quantitative Structure-Activity Relationship; Salicylic Acid / chemistry; Salicylic Acid / metabolism; Skin / metabolism; Skin Absorption; Swine; Testosterone / chemistry; Testosterone / metabolism; Water / chemistry
TL;DR:
Three artificial membranes were evaluated for their ability to predict the skin permeability of caffeine, cortisone, diclofenac sodium, mannitol, salicylic acid and testosterone applied in propylene glycol, water and ethanol as unsaturated and saturated concentrations and identified different physicochemical factors influencing the absorption process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Crossref
Added: December 24, 2021
2013 conference paper
Assessment of drug-vehicle interactions seen in topical delivery using three PAMPA artificial membrane systems.
Riviere, J. E., & Karadzovska, D. (2013, July 21). Presented at the 40th Annual Meeting & Exposition of the Controlled Release Society.
Event: 40th Annual Meeting & Exposition of the Controlled Release Society on July 21-24, 2013
Source: NC State University Libraries
Added: June 17, 2022
2013 journal article
Biological Surface Adsorption Index (BSAI): A molecular signature for nanomaterial interactions
Toxicologist, 132, 517.
Source: NC State University Libraries
Added: May 27, 2022
2013 conference paper
Comparison of ELISA and LC MS/MS for the measurement of flunixin plasma concentration in beef cattle after intravenous and subcutaneous administration
Shelver, W. L., Tell, L. A., Wagner, S., Wetzlich, S. E., Baynes, R. E., & Riviere, J. E. (2013, August 25). Presented at the 127th AOAC Annual Meeting & Exposition, Chicago, IL.
Event: 127th AOAC Annual Meeting & Exposition at Chicago, IL on August 25-28, 2013
Source: NC State University Libraries
Added: June 17, 2022
2013 journal article
Comparison of ELISA and LC-MS/MS for the Measurement of Flunixin Plasma Concentrations in Beef Cattle after Intravenous and Subcutaneous Administration
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61(11), 2679–2686.
author keywords: cattle; flunixin; ELISA; pharmacokinetics; elimination; administration; concentration
MeSH headings : Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Cattle; Chromatography, High Pressure Liquid / methods; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / blood; Enzyme-Linked Immunosorbent Assay / methods; Injections, Intravenous; Tandem Mass Spectrometry / methods; Veterinary Drugs / administration & dosage; Veterinary Drugs / blood
TL;DR:
Quantitative immunoassay was a satisfactory method of flunixin analysis and it would be difficult to differentiate routes of administration in healthy beef cattle based on the plasma elimination profile of fl unixin after IV or SC administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 conference paper
Comparison of flunixin pharmacokinetic and milk elimination in healthy cows and cows with mastitis
Proceedings of the 18th American Academy of Veterinary Pharmacology and Therapeutics Biennial Symposium. Presented at the 18th American Academy of Veterinary Pharmacology and Therapeutics Biennial Symposium, Potomac, MD.
Event: 18th American Academy of Veterinary Pharmacology and Therapeutics Biennial Symposium at Potomac, MD
Source: NC State University Libraries
Added: May 27, 2022
2013 journal article
Computational approaches and metrics needed for formulating biologically realistic nanomaterial pharmacokinetic models
Computational Science & Discovery, 6(1).
Source: NC State University Libraries
Added: June 3, 2022
2013 report
Developing a global curriculum for regulators
[Discussion Paper]. https://nam.edu/wp-content/uploads/2015/06/BGH-GlobalCurriculum.pdf
Source: NC State University Libraries
Added: June 3, 2022
2013 journal article
Dynamics of nanoparticle-protein corona complex. Analytical results from population balance equations
PlosOne, 8, 64690.
MeSH headings : Humans; Kinetics; Models, Statistical; Nanoparticles / chemistry; Nonlinear Dynamics; Particle Size; Protein Binding; Proteins / chemistry; Surface Properties
TL;DR:
The dynamics of biocorona formation constitute vital aspect of interactions between nanoparticles and living organisms, and modeling results for in vitro systems to better predict behavior for in vivo systems are modeled.
(via Semantic Scholar)
Source: Web Of Science
Added: May 27, 2022
2013 journal article
FARAD Digest: Effects of new sampling protocols on procaine penicillin G withdrawal intervals for cattle
Journal of the American Veterinary Medical Association, 243(10), 1408–1412,
Source: NC State University Libraries
Added: June 3, 2022
2013 conference paper
Food Safety: The interaction of pharmacometrics and veterinary medicine
Population Approach Group in Europe (PAGE) 2013 meeting, 20–21.
Source: NC State University Libraries
Added: May 27, 2022
2013 conference paper
Impact of nanoparticle protein corona on assessing in vitro cellular uptake of silver nanoparticles into human epidermal keratinocytes. 40th Annual Mtg
Monteiro-Riviere, N. A., Samberg, M., Oldenburg, S., & Riviere, J. E. (2013, July 21). Presented at the 40th Annual Meeting & Exposition of the Controlled Release Society, Honolulu, Hawaii.
Event: 40th Annual Meeting & Exposition of the Controlled Release Society at Honolulu, Hawaii on July 21-24, 2013
Source: NC State University Libraries
Added: June 17, 2022
2013 conference paper
In silico models for dermal absorption from complex formulations
Guth, K., Riviere, J., Brooks, J., Schafer-Korting, M., Dammann, M., Fabian, E., … Landsiedel, R. (2013, September). Presented at the 15th Congress of European Society for Alternatives to Animal Testing (EUSAAT), Linz, Austria.
Event: 15th Congress of European Society for Alternatives to Animal Testing (EUSAAT) at Linz, Austria
Source: NC State University Libraries
Added: May 27, 2022
2013 journal article
In silico models for dermal absorption from complex formulations
Naunyn-Schmiedelberg’s Archives of Pharmacology, 386, 29.
Source: NC State University Libraries
Added: May 27, 2022
2013 journal article
Limitations of MIC as the sole criterion in antimicrobial drug dosage regimen design: The need for full characterization of antimicrobial pharmacodynamic profile especially for drug-resistant organisms
The Veterinary Journal, 198(1), 15–18.
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacokinetics; Anti-Infective Agents / pharmacology; Bacteria / drug effects; Drug Resistance, Bacterial; Microbial Sensitivity Tests / methods; Microbial Sensitivity Tests / veterinary; Models, Biological
TL;DR:
The conventional measure of a target pathogen’s sensitivity to an antimicrobial drug is the minimum concentration that will inhi-bit visible growth in vitro after overnight incubation (MIC), which is based on exposure of bacterial cultures to serial dilutions of anti-microbial concentrations.
(via Semantic Scholar)
Source: Crossref
Added: December 24, 2021
2013 journal article
Modeling the effect of experimental variables on the in vitro permeation of six model compounds across porcine skin
International Journal of Pharmaceutics, 443(1-2), 58–67.
author keywords: Quantitative structure-permeability; relationships (QSPeRs); Experimental variables; Mixture factor; Steady-state flux; Percutaneous absorption
MeSH headings : Animals; Drug Carriers; Female; Hydrogen Bonding; In Vitro Techniques; Models, Biological; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Quantitative Structure-Activity Relationship; Regression Analysis; Skin / metabolism; Skin Absorption; Swine
TL;DR:
Development and statistical validation of QSPeR models that incorporate the effects of penetrant, vehicle, and experimental conditions such as dose volume (finite/infinite), and saturation level (saturated/unsaturated).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018
2013 conference paper
Nanomaterial pharmacokinetics and biodistribution: Can in vitro data quantitatively predict in vivo?
Riviere, J. E., & Monteiro-Riviere, N. A. (2013, October 28). Presented at the 6th International Symposium on Nanotechnology, Occupational and Environmental Health., Nagoya, Japan.
Event: 6th International Symposium on Nanotechnology, Occupational and Environmental Health. at Nagoya, Japan on October 28-31, 2013
Source: NC State University Libraries
Added: June 17, 2022
2013 journal article
Occurrence of flunixin residues in bovine milk samples from the USA
Food Additives & Contaminants: Part A, 30(9), 1513–1516.
author keywords: flunixin; milk residues; UPLC-MS; CHARM((R)); milk; food safety
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Cattle; Chromatography, High Pressure Liquid; Clonixin / analogs & derivatives; Clonixin / analysis; Clonixin / metabolism; Dairying / legislation & jurisprudence; Drug Residues / analysis; Enzyme-Linked Immunosorbent Assay; Food Contamination / legislation & jurisprudence; Food Handling; Food Inspection / legislation & jurisprudence; Guideline Adherence; Legislation, Food; Milk / chemistry; Milk / standards; Spectrometry, Mass, Electrospray Ionization; Transportation; United States; United States Department of Agriculture; United States Food and Drug Administration
TL;DR:
The results of this study indicate that flunixin residues in milk are possible, and regulatory agencies should be aware that such residues can occur, and should consider incorporating or expanding flunxin screening tests as part of routine drug monitoring in milk.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Of mice, men and nanoparticle biocoronas: are in vitro to in vivo correlations and interspecies extrapolations realistic?
Nanomedicine, 8(9), 1357–1359.
author keywords: biocorona; biodistribution; in vitro-in vivo correlation; interspecies extrapolation; nanoparticle; pharmacokinetics; protein corona
MeSH headings : Drug Delivery Systems; Humans; Lipids / administration & dosage; Lipids / chemistry; Nanoparticles / administration & dosage; Nanoparticles / chemistry; RNA, Small Interfering / administration & dosage; RNA, Small Interfering / chemistry
TL;DR:
These issues have not been adequately considered by the nanomedicine or nanotoxicology commu nity, and are even ignored in current risk assess ment paradigms, yet are crucial for making biologically meaningful extrapolations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(OpenAlex)
Source: Crossref
Added: December 24, 2021
2013 journal article
Prediction of flunixin tissue residue concentrations in livers from diseased cattle
Food and Chemical Toxicology, 62, 876–879.
author keywords: Flunixin; Population pharmacokinetics; Tissue residue; Monte Carlo simulation
TL;DR:
The objective of this analysis was to explore how the changes in pharmacokinetic (PK) parameters that may be associated with diseased animals affect the predicted liver residue of flunixin in cattle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Protein binding effects cellular uptake of silver nanoparticles in human cells
Toxicologist, 132, 283–284.
Source: NC State University Libraries
Added: May 27, 2022
2013 journal article
Protein binding modulates the cellular uptake of silver nanoparticles into human cells: Implications for in vitro to in vivo extrapolations?
TOXICOLOGY LETTERS, 220(3), 286–293.
Contributors: N. Monteiro-Riviere n , M. Samberg n, S. Oldenburg* & n
author keywords: Protein corona; Protein binding of nanoparticles; Cellular uptake of silver nanoparticles; Albumin cell uptake; Transferrin cell uptake; IgG cell uptake
MeSH headings : Humans; Immunoglobulin G / metabolism; Keratinocytes / metabolism; Metal Nanoparticles / chemistry; Microscopy, Electron, Transmission; Protein Binding; Serum Albumin / metabolism; Silver / metabolism; Transferrin / metabolism
TL;DR:
NP association with different serum proteins, purportedly forming different protein coronas, significantly modulates Ag uptake into HEK compared to native NP uptake, suggesting caution in extrapolating in vitro uptake data to predict behavior in vivo where the nature of the protein corona may determine patterns of cellular uptake, and thus biodistribution, biological activity and toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 conference paper
Protein corona effects silver nanoparticle uptake in human cells
Presented at the 4th Annual Nanofronteirs Symposium, Columbia, MO.
Event: 4th Annual Nanofronteirs Symposium at Columbia, MO
Source: NC State University Libraries
Added: June 17, 2022
2013 conference paper
Skin exposure to nanomaterials: Should we be concerned?
The 6th International Symposium on Nanotechnology, Occupational and Environmental Health, 48. Nagoya, Japan.
Source: NC State University Libraries
Added: May 27, 2022
2013 journal article
Solubility criteria for veterinary drugs: Workshop report
Pharm. Forum, 39(3).
Source: NC State University Libraries
Added: May 27, 2022
2013 conference paper
The application of modeling and simulation for animal health (therapeutics): Gaps, challenges and opportunities
Proceedings of the 18th American Academy of Veterinary Pharmacology and Therapeutics Biennial Symposium. Presented at the 18th American Academy of Veterinary Pharmacology and Therapeutics Biennial Symposium, Potomac, MD.
Event: 18th American Academy of Veterinary Pharmacology and Therapeutics Biennial Symposium at Potomac, MD
Source: NC State University Libraries
Added: May 27, 2022
2013 chapter
Transforming the animal health regulatory system for the 21st century. The Institute of Computational Comparative Medicine and the Animal Health Regulatory Science Initiative
In Proceedings One Hundred and Seventeenth Annual Meeting of the United States Animal Health Association (p. 136). https://www.usaha.org/upload/Proceedings/USAHAProceedings-2013-117th.pdf
Event: 107th Annual Meeting of the United States Animal Health Association at San Diego, CA on October 17-23, 2013
Source: NC State University Libraries
Added: June 17, 2022
2013 journal article
Vasomodulation Influences on the Transdermal Delivery of Ibuprofen
Journal of Pharmaceutical Sciences, 102(11), 4072–4078.
author keywords: transdermal delivery; ibuprofen; vasodilation; blood flow; skin; permeation enhancer; formulation vehicle; pharmacokinetics
MeSH headings : Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Ibuprofen / administration & dosage; Ibuprofen / blood; Ibuprofen / pharmacokinetics; Papaverine / pharmacology; Permeability / drug effects; Rabbits; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Tolazoline / administration & dosage; Tolazoline / pharmacology; Vasodilator Agents / administration & dosage; Vasodilator Agents / pharmacology
TL;DR:
Transdermal formulations of ibuprofen containing low concentrations of tolazoline or papaverine increased plasma ib uprofen levels in the presence of passive PE components, and vasodilator enhancement to ibUprofen delivery was evaluated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: December 24, 2021
2013 journal article
What to do about unsafe medicines?
British Medical Journal, 347, 5064,
MeSH headings : Drug Industry / legislation & jurisprudence; Drug Industry / standards; Female; Humans; Male; Patient Education as Topic; Patient Safety / legislation & jurisprudence; Prescription Drugs / standards; Quality Assurance, Health Care
TL;DR:
Because buyers cannot be aware of deceit in the sale of drugs, regulators need to balance the scales.
(via Semantic Scholar)
Source: Web Of Science
Added: May 27, 2022
2012 journal article
A Novel Long-Acting Transdermal Fentanyl Solution for Dogs
Journal of Veterinary Pharmacology and Therapeutics, 35(Supplement 2), 1.
Ed(s):
Source: NC State University Libraries
Added: June 17, 2022
2012 chapter
Absorption
In E. Hodgson (Ed.), Pesticide Biotransformation and Disposition (pp. 25–52). New York: Elsevier.
Ed(s): E. Hodgson
Source: NC State University Libraries
Added: June 17, 2022
2012 journal article
Acute vascular effects of nanoparticle infusion in isolated perfused skin
Nanomedicine: Nanotechnology, Biology and Medicine, 8(4), 428–431.
Contributors: n, T. Leavens n , J. Brooks n & N. Monteiro-Riviere n
author keywords: Nanoparticles; Vascular toxicity; In vitro; Biodistribution
MeSH headings : Animals; Female; Perfusion; Quantum Dots; Skin / blood supply; Skin / pathology; Skin / physiopathology; Sus scrofa; Vascular Resistance / drug effects
TL;DR:
Specific nanoparticle infusions were demonstrated to be associated with significant acute vascular physiological effects, and these observations suggest certain nanoparticles infusions may beassociated with acute vascular physiologic effects that merit further attention.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2012 journal article
Acute vascular effects of nanoparticle infusion in isolated perfused skin
[Poster]. Toxicologist, 126, 18. https://www.toxicology.org/pubs/docs/Tox/2012Tox.pdf
Event: 51st Annual Meeting and ToxExpo at San Francisco, CA on March 11-15, 2012
Source: NC State University Libraries
Added: June 17, 2022
2012 journal article
Challenges obtaining a biowaiver for topical veterinary dosage forms
Journal of Veterinary Pharmacology and Therapeutics, 35(SUPPL. 1), 103–114.
Contributors: R. Baynes n , n, T. Franz, N. Monteiro-Riviere n , P. Lehman, M. Peyrou *, P. Toutain *
MeSH headings : Administration, Topical; Animals; Dosage Forms; Drug Administration Routes; Legislation, Drug; Species Specificity; Therapeutic Equivalency; Veterinary Drugs / administration & dosage; Veterinary Drugs / chemistry; Veterinary Drugs / pharmacokinetics
TL;DR:
The focus of this paper is to address several of the challenges associated with determining the BE of these locally acting drugs and critically examine the current technological advances that can act as a surrogate for clinical trials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 chapter
Dermal Toxicity
In R. Gupta (Ed.), Veterinary Toxicology: Basic and Clinical Principles (2nd ed., pp. 337–350,). New York: Elsevier.
Ed(s): R. Gupta
Source: NC State University Libraries
Added: June 17, 2022
2012 chapter
Distribution and Pharmacokinetic Models
In E. Hodgson (Ed.), Pesticide Biotransformation and Disposition (pp. 117–148). New York: Elsevier.
Ed(s): E. Hodgson
Source: NC State University Libraries
Added: June 17, 2022
2012 journal article
Effect of eight different nanoparticles of different sizes and shapes on human epidermal keratinocytes
[Conference abstract]. Journal of Investigative Dermatology, 132(S1), S52.
Source: NC State University Libraries
Added: June 17, 2022
2012 book
Ensuring Safe Foods and Medical Products through Strong Regulatory Systems Abroad
https://nap.nationalacademies.org/catalog/13296/ensuring-safe-foods-and-medical-products-through-stronger-regulatory-systems-abroad
Ed(s): & G. Buckley
Source: NC State University Libraries
Added: June 17, 2022
2012 journal article
Evaluation of factors important in modeling plasma concentrations of tetracycline hydrochloride administered in water in swine
AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(10), 1641–1649.
TL;DR:
The factors found to be of importance, combined with knowledge of the individual pharmacokinetic and chemical properties of medications currently approved for administration in water, may be useful in more prudent administration of approved medications administered to swine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Experimental factors affecting in vitro absorption of six model compounds across porcine skin
Toxicology in Vitro, 26(7), 1191–1198.
author keywords: Dermal absorption/penetration; Diffusion cells; Saturated; Unsaturated; Finite; Infinite; Albumin
MeSH headings : Administration, Cutaneous; Animals; Cattle; Diffusion; Female; In Vitro Techniques; Models, Biological; Permeability / drug effects; Serum Albumin, Bovine / metabolism; Skin / drug effects; Skin / metabolism; Skin Absorption; Swine; Xenobiotics / administration & dosage; Xenobiotics / pharmacokinetics
TL;DR:
The overall results emphasize the importance of experimental design and confirm previous findings that identified dose volume, saturation level and vehicle as the main sources of variation in the in vitro assessment of dermal absorption, whilst diffusion cell model and the presence/absence of BSA in the receptor phase had minimal effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018
2012 journal article
In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps
JOURNAL OF APPLIED TOXICOLOGY, 32(11), 913–919.
Contributors: T. Leavens n , N. Monteiro-Riviere n , A. Inman n, J. Brooks n, S. Oldenburg* & n
author keywords: silver nanoparticles; biodistribution; skin
MeSH headings : Animals; Metal Nanoparticles / chemistry; Nanoparticles / chemistry; Perfusion; Silver / chemistry; Silver / pharmacokinetics; Skin / metabolism; Swine / metabolism; Tissue Distribution
TL;DR:
The objective of the present study was to quantify the local biodistribution of two types of Ag nanoparticles, Ag‐citrate and Ag‐silica, in the isolated perfused porcine skin flap (IPPSF), and found no detectable elimination of Ag from the system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 conference paper
In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps
[Poster]. Toxicologist, 126, 17. https://www.toxicology.org/pubs/docs/Tox/2012Tox.pdf
Event: 51st Annual Meeting and ToxExpo at San Francisco, CA on March 11-15, 2012
Source: NC State University Libraries
Added: June 17, 2022
2012 journal article
LACK OF HYDROXYLATED FULLERENE TOXICITY AFTER INTRAVENOUS ADMINISTRATION TO FEMALE SPRAGUE-DAWLEY RATS
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 75(7), 367–373.
Contributors: N. Monteiro-Riviere n , K. Linder n, A. Inman n, J. Saathoff n, X. Xia n & n
MeSH headings : Animals; Blood Chemical Analysis; Drug Administration Schedule; Female; Fullerenes / administration & dosage; Fullerenes / chemistry; Fullerenes / toxicity; Injections, Intravenous; Liver / drug effects; Lymphocytes / drug effects; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / toxicity; Rats; Rats, Sprague-Dawley; Thymus Gland / drug effects; Toxicity Tests, Acute; Urinalysis
TL;DR:
These experiments suggest that this fullerol was well tolerated after iv administration to rats, and no clinically significant chemistry changes were observed after treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2012 conference paper
Mapping the surface adsorption forces of nanomaterials in biological systems
Presented at the NIEHS Nanotechnology Health Implications Research Consortium Meeting, Research Triangle Park, NC.
Event: NIEHS Nanotechnology Health Implications Research Consortium Meeting at Research Triangle Park, NC on January 26-27, 2012
Source: NC State University Libraries
Added: July 29, 2022
2012 chapter
Nanoscale feed ingredients and animal and human health
In J. Fink-Gremmels (Ed.), Animal feed contamination : effects on livestock and food safety (pp. 540–553). Philadelphia, PA: Woodhead Publishing.
Ed(s): J. Fink-Gremmels
Source: NC State University Libraries
Added: June 17, 2022
2012 journal article
Oxidative Stress and Dermal Toxicity of Iron Oxide Nanoparticles In Vitro
CELL BIOCHEMISTRY AND BIOPHYSICS, 67(2), 461–476.
Contributors: A. Murray*, E. Kisin*, A. Inman n, S. Young*, M. Muhammed *, T. Burks*, A. Uheida*, A. Tkach*
author keywords: Nanoparticles; Skin exposure; Ultraviolet radiation; Iron oxide
MeSH headings : Biological Transport; Cell Survival / drug effects; Cytokines / metabolism; Glutathione / metabolism; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; L-Lactate Dehydrogenase / metabolism; Magnetite Nanoparticles / chemistry; Magnetite Nanoparticles / toxicity; NF-kappa B / metabolism; Oxidative Stress / drug effects; Particle Size; Skin / cytology; Skin / drug effects; Transcription Factor AP-1 / metabolism
TL;DR:
Data indicate that co-exposure to UVB and SPIONs was associated with induction of oxidative stress and release of inflammatory mediators, verifying the need to thoroughly evaluate the adverse effects of UVB when evaluating dermal toxicity of engineered NPs on skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 conference paper
Pharmacokinetics and milk elimination of flunixin in dairy cattle following different routes of administration
Waltman, L., Smith, G. W., Leavens, T. L., Baynes, R. E., & Riviere, J. E. (2012, June 3). Abstract presented at the 27th World Buiatrics Congress, Lisbon, Portugal.
Event: 27th World Buiatrics Congress at Lisbon, Portugal on June 3-8, 2012
Source: NC State University Libraries
Added: June 17, 2022
2012 journal article
Pharmacokinetics and tissue elimination of tulathromycin following subcutaneous administration in meat goats
AMERICAN JOURNAL OF VETERINARY RESEARCH, 73(10), 1634–1640.
MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Disaccharides / blood; Disaccharides / pharmacokinetics; Female; Goats / blood; Goats / metabolism; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Injections, Subcutaneous / veterinary; Male; Tandem Mass Spectrometry / veterinary; Time Factors; Tissue Distribution
TL;DR:
The tissue depletion profile of tulathromycin was determined and an appropriate slaughter withdrawal interval in meat goats after multiple SC injections of the drug was determined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 conference paper
Pharmacokinetics and tissue elimination of tulathromycin following subcutaneous administration in meat goats
Smith, G. W., Romanet, J. L., Leavens, T. L., Tell, L. A., Baynes, R. E., & Riviere, J. E. (2012, June). Abstract presented at the 27th World Buiatrics Congress, Lisbon, Portugal.
Event: 27th World Buiatrics Congress at Lisbon, Portugal on June 3-8, 2012
Source: NC State University Libraries
Added: June 17, 2022
2012 journal article
Plasma pharmacokinetics and milk residues of flunixin and 5-hydroxy flunixin following different routes of administration in dairy cattle
Journal of Dairy Science, 95(12), 7151–7157.
author keywords: flunixin; residue; pharmacology
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / analysis; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / analysis; Clonixin / blood; Clonixin / pharmacokinetics; Drug Residues / analysis; Female; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Injections, Subcutaneous / veterinary; Milk / chemistry
TL;DR:
Cattle that received FLU by the approved (intravenous) route consistently eliminated the drug before the approved withdrawal times; however, residues can persist beyond these approved times following intramuscular or subcutaneous administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 chapter
Potential Health Risks of Nanoparticles
In Q. Huang (Ed.), Nanotechnology in the Food, Beverage and Nutraceutical Industries (pp. 40–55). Cambridge: Woodhead Publishing.
Ed(s): Q. Huang
Source: NC State University Libraries
Added: June 17, 2022
2012 review
Predicting skin permeability from complex vehicles
[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 65(2), 265–277.
Contributors: D. Karadzovska n, J. Brooks n, N. Monteiro-Riviere n & n
author keywords: Chemical mixtures; Formulations; Percutaneous/dermal absorption; Quantitative structure-permeation relationship (QSPR); QSAR; Linear free energy relationships (LFER); Mixture factor; Topical drug delivery enhancers
MeSH headings : Animals; Drug Delivery Systems; Humans; Linear Energy Transfer; Models, Theoretical; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Pharmaceutical Vehicles / chemistry; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption
TL;DR:
This review highlights the progress made in predicting skin permeability from complex vehicles by extending the use of quantitative structure-permeation relationship (QSPR) models based on linear free energy relationships (LFER) to predict dermal absorption from complex mixtures with the inclusion of significant molecular descriptors such as a mixture factor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Solubility criteria for veterinary drugs
Pharmacopeial Forum, 38(4), 44–54. https://www.usp.org/sites/default/files/usp/document/our-work/chemical-medicines/pf39-4_vet.pdf
Source: NC State University Libraries
Added: June 17, 2022
2012 journal article
The effect of formulations and experimental conditions on in vitro human skin permeation—Data from updated EDETOX database
International Journal of Pharmaceutics, 434(1-2), 280–291.
author keywords: QSAR; Skin; Dermal; Permeation; Absorption; In vitro; Decision tree; Finite dosing; Occlusion; Hydration
MeSH headings : Data Mining; Databases, Factual; Humans; Models, Biological; Models, Statistical; Permeability; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / metabolism; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption
TL;DR:
The work resulted in statistically valid models for estimation of the skin flux from varying experimental conditions, including relevant real-world mixture exposure scenarios, which will aid assessment of the utility of dermal absorption data collected under different conditions with broad implications on transdermal delivery research.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2012 conference paper
Toxicity assessment of citrate biopure silver and silica-coated silver in human skin cells
Toxicologist, 126, 146. https://www.toxicology.org/pubs/docs/Tox/2012Tox.pdf
Event: 51st Annual Meeting and ToxExpo at San Francisco, CA on March 11-15, 2012
Source: NC State University Libraries
Added: June 17, 2022
2012 conference paper
Toxicity assessment of eight nanoparticles in human epidermal keratinocytes
[Poster]. Toxicologist, 126, 146. https://www.toxicology.org/pubs/docs/Tox/2012Tox.pdf
Event: 51st Annual Meeting and ToxExpo at San Francisco, CA on March 11-15, 2012
Source: NC State University Libraries
Added: June 17, 2022
2012 journal article
Use of population pharmacokinetic modeling and Monte Carlo simulation to capture individual animal variability in the prediction of flunixin withdrawal times in cattle
Journal of Veterinary Pharmacology and Therapeutics, 36(3), 248–257.
MeSH headings : Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Cattle / blood; Clonixin / administration & dosage; Clonixin / analogs & derivatives; Clonixin / pharmacokinetics; Computer Simulation; Drug Administration Routes; Drug Residues / pharmacokinetics; Female; Liver / metabolism; Male; Models, Biological; Monte Carlo Method
TL;DR:
This study questions the use of small groups of healthy animals to determine WDTs for drugs intended for administration to large diverse populations and may warrant a reevaluation of the current procedure for establishing WDT to prevent violative residues of flunixin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 conference paper
Vehicle effects on the absorption of finite and infinite saturated doses of caffeine, mannitol, and testosterone in porcine skin.
[Poster Session]. Toxicologist, 126, 123. https://www.toxicology.org/pubs/docs/Tox/2012Tox.pdf
Event: 51st Annual Meeting and ToxExpo at San Francisco, CA on March 11-15, 2012
Source: NC State University Libraries
Added: June 17, 2022
2011 chapter
Absorption, penetration and cutaneous toxicity of jet fuel and hydrocarbon components
In M. Witten, E. Zeiger, & G. D. Ritchie (Eds.), Jet Fuel Toxicology (pp. 119–134). Boca Raton, FL.: CRC Press:
Ed(s): M. Witten, E. Zeiger & G. Ritchie
Source: NC State University Libraries
Added: June 17, 2022
2011 book
Comparative Pharmacokinetics: Principles, Techniques and Applications
(2nd ed.). Chichester, West Sussex, UK: Wiley-Blackwell.
Source: NC State University Libraries
Added: June 17, 2022
2011 book
Comparative pharmacokinetics principles, techniques, and applications
TL;DR:
Introduction principles of drug movement in the body absorption distribution renal elimination hepatic biotransformation and biliary excretion compartmental and noncompartmental models nonlinear models physiological models dosage regimens applied to clinical pharmacokinetics dosage adjustment in renal diseases interspecies extrapolations tissue residues and withdrawal times.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2011 conference paper
Dermal penetration of UVB-damaged skin by titanium- and zinc oxide nanoparticles in sunscreen formulations
[Poster]. Naunyn-Schmiedebergs Archives of Pharmacology, 383(S1), 101.
Event: 77th Annual Meeting Deutsche Gesellschaft für Experimentelle und Klinische Pharmakologie und Toxikologie e.V. at Frankfurt am Main, Germany on March 30 - April 1, 2011
Source: NC State University Libraries
Added: June 17, 2022
2011 journal article
Development of a physiologically based pharmacokinetic model to predict tulathromycin distribution in goats
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(2), 121–131.
MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Computer Simulation; Disaccharides / blood; Disaccharides / pharmacokinetics; Goats / blood; Goats / metabolism; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Models, Biological; Sensitivity and Specificity; Software; Tissue Distribution
TL;DR:
The developed model and compilation of physiological parameters for goats provide initial tools that can be used as a basis for predicting withdrawal times of drugs in this minor species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 conference paper
Development of physiologically based pharmacokinetic (PBPK) model to predict tulathromycin distribution in goats
[Abstract]. The Toxicologist, 120(2), 153. https://www.toxicology.org/pubs/docs/Tox/2011Tox.pdf
Event: 50th Anniversary Annual Meeting and ToxExpo at Washington, D.C. on March 6-10, 2011
Source: NC State University Libraries
Added: June 17, 2022
2011 conference paper
Evaluation of toxicity and inflammation in three different hydroxylated fullerenes (C60(OH)x inhuman cells
[Abstract]. The Toxicologist, 120(2), 251. https://www.toxicology.org/pubs/docs/Tox/2011Tox.pdf
Event: 50th Anniversary Annual Meeting and ToxExpo at Washington, D.C. on March 6-10, 2011
Source: NC State University Libraries
Added: June 17, 2022
2011 conference paper
In vitro evaluation of the effects of dose, receptor fluid, and vehicle on the absorption of five physiochemically different compounds in porcine skin
[Abstract]. The Toxicologist, 120, 136. https://www.toxicology.org/pubs/docs/Tox/2011Tox.pdf
Event: 50th Anniversary Annual Meeting and ToxExpo at Washington, D.C. on March 6-10, 2011
Source: NC State University Libraries
Added: June 17, 2022
2011 journal article
In vitro toxicity assessment of three hydroxylated fullerenes in human skin cells
TOXICOLOGY IN VITRO, 25(8), 2105–2112.
Contributors: J. Saathoff n, A. Inman n, X. Xia n, n & N. Monteiro-Riviere n
author keywords: Hydroxylated fullerenes; Fullerenes; Cytotoxicity; Skin cells; Keratinocytes; Nanoparticles
MeSH headings : Biological Transport; Cell Survival; Cells, Cultured; Fullerenes / chemistry; Fullerenes / metabolism; Fullerenes / toxicity; Humans; Hydroxylation; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Microscopy, Electron, Transmission; Photoelectron Spectroscopy; Spectrometry, Fluorescence
TL;DR:
Results suggest that different hydroxylation of fullerenes caused no cytotoxicity or inflammation up to 8.55 μg/ml, and suggest that extrapolation across similar NP will be dependent upon surface chemistry and concentration which may affect the degree of agglomeration and thus biological effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 conference paper
Iron oxide nanoparticles cause oxidative stress and dermal toxicity
[Abstract]. The Toxicologist, 120(2), 444. https://www.toxicology.org/pubs/docs/Tox/2011Tox.pdf
Event: 50th Anniversary Annual Meeting and ToxExpo at Washington, D.C. on March 6-10, 2011
Source: NC State University Libraries
Added: June 17, 2022
2011 journal article
Mapping the Surface Adsorption Forces of Nanomaterials in Biological Systems
ACS NANO, 5(11), 9074–9081.
Contributors: X. Xia n, N. Monteiro-Riviere n , S. Mathur *, X. Song *, L. Xiao*, S. Oldenberg*, B. Fadeel *, n
author keywords: engineered nanomaterials; surface adsorption; risk assessment; nanotoxicology; nanomedicine; nanomaterial characterization
MeSH headings : Adsorption; Biology; Nanostructures / chemistry; Surface Properties
TL;DR:
The BSAI nanodescriptors are intrinsic properties of nanomaterials useful for quantitative structure-activity relationship (QSAR) model development and could open a quantitative avenue in predictive nanomedicine development, risk assessment, and safety evaluation of nanmaterials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Pet food safety: a shared concern
BRITISH JOURNAL OF NUTRITION, 106, S78–S84.
author keywords: Salmonella enterica; Melamine; Mycotoxins; Microbiological safety; Chemical safety; Toxicology; Analytical methods
MeSH headings : Animal Diseases / etiology; Animal Diseases / prevention & control; Animal Feed / analysis; Animal Feed / microbiology; Animals; Cost-Benefit Analysis; Food Analysis; Food Contamination / prevention & control; Food Microbiology / standards; Pets; Safety; Toxicity Tests / economics
TL;DR:
The following summary provides an introduction to the issues, challenges and new tools being developed to ensure that commercial pet foods are both nutritious and safe.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Pharmacokinetics of tulathromycin after single and multiple subcutaneous injections in domestic goats (Capra aegagrus hircus)
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 34(5), 448–454.
MeSH headings : Aging; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Disaccharides / administration & dosage; Disaccharides / blood; Disaccharides / pharmacokinetics; Drug Administration Schedule; Female; Goats / blood; Half-Life; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Male
TL;DR:
Overall, pharmacokinetic parameters in goats are similar to those reported in cattle and swine, and tulathromycin may prove a useful drug for treating respiratory disease in goats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 conference paper
Predicting skin permeability from complex chemical mixtures: The impact of biologuical skin model system on quantitative structure permeability relationships (QSPR
[Abstract]. The Toxicologist, 120(2), 136. https://www.toxicology.org/pubs/docs/Tox/2011Tox.pdf
Event: 50th Anniversary Annual Meeting and ToxExpo at Washington, D.C. on March 6-10, 2011
Source: NC State University Libraries
Added: June 17, 2022
2011 journal article
Quantum dot penetration into viable human skin
NANOTOXICOLOGY, 6(2), 173–185.
Contributors: T. Prow *, N. Monteiro-Riviere n , A. Inman n, J. Grice *, X. Chen *, X. Zhao *, W. Sanchez*, A. Gierden*
author keywords: Nanoparticles; exposure; nanotoxicology; surface chemistry
MeSH headings : Diffusion Chambers, Culture; Female; Humans; Hydrogen-Ion Concentration; Microscopy, Confocal; Nanoparticles; Particle Size; Polyethylene Glycols / metabolism; Polyethylene Glycols / pharmacology; Quantum Dots; Skin / chemistry; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Tissue Culture Techniques
TL;DR:
Systematic studies probing the effects of nanoparticle surface modification and formulation pH are important in nanotoxicology and nanomedicine and this study uses laser-scanning fluorescence confocal microscopy to evaluate nanoparticle penetration in viable excised human skin that was intact or tape-stripped.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 journal article
Safety Evaluation of Sunscreen Formulations Containing Titanium Dioxide and Zinc Oxide Nanoparticles in UVB Sunburned Skin: An In Vitro and In Vivo Study
TOXICOLOGICAL SCIENCES, 123(1), 264–280.
Contributors: N. Monteiro-Riviere n , K. Wiench *, R. Landsiedel *, S. Schulte *, A. Inman n & n
author keywords: sunscreens; sunburn skin; titanium dioxide (TiO2); zinc oxide (ZnO); nanoparticles; skin penetration
MeSH headings : Animals; Erythema / etiology; Erythema / pathology; Erythema / prevention & control; In Vitro Techniques; Metal Nanoparticles / radiation effects; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Particle Size; Skin / drug effects; Skin / pathology; Skin / radiation effects; Skin / ultrastructure; Sunburn / drug therapy; Sunburn / etiology; Sunburn / pathology; Sunscreening Agents / pharmacokinetics; Sunscreening Agents / toxicity; Swine / physiology; Titanium / pharmacokinetics; Titanium / radiation effects; Titanium / toxicity; Ultraviolet Rays / adverse effects; Zinc Oxide / pharmacokinetics; Zinc Oxide / radiation effects; Zinc Oxide / toxicity
TL;DR:
UVB-damaged skin slightly enhanced TiO(2) NP or ZnO NP penetration in sunscreen formulations but no transdermal absorption was detected.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2011 conference paper
Skin pH effects the penetration of quantum dot nanoparticles in porcine skin
[Abstract]. The Toxicologist, 120(2), 462. https://www.toxicology.org/pubs/docs/Tox/2011Tox.pdf
Event: 50th Anniversary Annual Meeting and ToxExpo at Washington, D.C. on March 6-10, 2011
Source: NC State University Libraries
Added: June 17, 2022
2011 journal article
Terpene effects on penetration of nanoparticles in human skin
[Abstract]. The Toxicologist, 120(2), 462. https://www.toxicology.org/pubs/docs/Tox/2011Tox.pdf
Event: 50th Anniversary Annual Meeting and ToxExpo at Washington, D.C. on March 6-10, 2011
Source: NC State University Libraries
Added: June 17, 2022
2011 journal article
Tulathromycin assay validation and tissue residues after single and multiple subcutaneous injections in domestic goats (Capra aegagrus hircus)
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(2), 113–120.
MeSH headings : Adipose Tissue; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Disaccharides / administration & dosage; Disaccharides / blood; Disaccharides / pharmacokinetics; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Residues; Female; Goats / metabolism; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Infusions, Subcutaneous; Kidney; Liver; Lung; Male; Muscle, Skeletal; Reproducibility of Results; Tissue Distribution
TL;DR:
It is demonstrated that tissue levels in goats are very similar to those seen in swine and cattle, and below limit of quantification in injection site and lung by day 18 and in liver, kidney, muscle, and fat at all time points.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
A time to change: update on methods and manuscript topics appropriate for the journal of veterinary pharmacology and therapeutics
Journal of Veterinary Pharmacology and Therapeutics, 33(5), 415–415.
Source: Crossref
Added: December 24, 2021
2010 chapter
Absorption
In R. I. Krieger (Ed.), Hayes' handbook of pesticide toxicology (3rd ed., Vol. 1, pp. 877–892). New York: Academic Press.
Ed(s): R. Krieger
Source: NC State University Libraries
Added: July 29, 2022
2010 journal article
An index for characterization of nanomaterials in biological systems
Nature Nanotechnology, 5(9), 671–675.
Contributors: X. Xia n, N. Monteiro-Riviere n & n
MeSH headings : Adsorption; Hormones / chemistry; Models, Chemical; Nanostructures / chemistry; Nanotubes, Carbon / chemistry; Proteins / chemistry; Small Molecule Libraries / chemistry; Steroids / chemistry
TL;DR:
The method successfully predicted the adsorption of various small molecules onto carbon nanotubes, and the nanodescriptors can be used to develop pharmacokinetic and safety assessment models for nanomaterials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2010 chapter
Basic Principles Involved in Quantifying the Dermal Absorption of Topically Applied Chemicals
In N. A. Monteiro-Riviere (Ed.), Toxicology of the Skin (pp. 43–54). New York, NY: Informa Healthcare.
Ed(s): N. Monteiro-Riviere
Source: NC State University Libraries
Added: August 20, 2022
2010 conference paper
Biological Surface Adsorption Index: A novel metric to characterize nanomaterial interaction in biological systems
SETAC North America 31st Annual Meeting Abstract Book, 60.
Event: 31st Annual Meeting, Society of Environmental Toxicology and Chemistry at Portland, OR on November 7-11, 2010
Source: NC State University Libraries
Added: June 17, 2022
2010 conference paper
Biological surface activity index: A novel metric to characterize nanomaterial interactions in biological systems
[Abstract]. The Toxicologist, 114(S1), 61–62. https://www.toxicology.org/pubs/docs/Tox/2010Tox.pdf
Event: 49th Annual Meeting and ToxExpo at Salt Lake City, UT on March 7-11, 2010
Source: NC State University Libraries
Added: June 17, 2022
2010 conference paper
Characterization of the surface adsorption properties of multiwalled carbon nanotubes in biological conditions via quantitative structure activity relationship (QSAR
[Abstract]. The Toxicologist, 114(S1), 170. https://www.toxicology.org/pubs/docs/Tox/2010Tox.pdf
Event: 49th Annual Meeting and ToxExpo at Salt Lake City, UT on March 7-11, 2010
Source: NC State University Libraries
Added: July 22, 2022
2010 chapter
Dermal absorption modeling
In M. Lazaridis & I. Colbeck (Eds.), Human exposure to pollutants via dermal absorption and inhalation (pp. 237–249). Dordrecht, the Netherlands: Springer.
Ed(s): M. Lazaridis & I. Colbeck
Source: NC State University Libraries
Added: June 17, 2022
2010 chapter
Dermal chemical mixtures
In M. M. Mumtaz (Ed.), Principles and Practice of Mixture Toxicology (pp. 273–300). Weinheim, Germany: Wiley-VCH Verlag.
Ed(s): M. Mumtaz
Source: NC State University Libraries
Added: June 17, 2022
2010 journal article
Determination of a wider chemical space can improve estimates of skin permeability
[Abstract]. The Toxicologist, 114(S1), 109. https://www.toxicology.org/pubs/docs/Tox/2010Tox.pdf
Event: 49th Annual Meeting and ToxExpo at Salt Lake City, UT on March 7-11, 2010
Source: NC State University Libraries
Added: June 17, 2022
2010 journal article
Disposition of melamine residues in blood and milk from dairy goats exposed to an oral bolus of melamine
FOOD AND CHEMICAL TOXICOLOGY, 48(8-9), 2542–2546.
author keywords: Triazines; Melamine; Ruminants; Pharmacokinetics
MeSH headings : Animals; Chromatography, High Pressure Liquid; Dairying; Female; Food Contamination; Goats / metabolism; Half-Life; Linear Models; Mass Spectrometry; Milk / chemistry; Tissue Distribution; Triazines / blood; Triazines / pharmacokinetics
TL;DR:
The pharmacokinetics of melamine in ruminants is not predictive from monogastrics and milk from similarly exposed animals should be condemned for at least 4days after the last exposure to avoid violation of proposed MRLs or safe levels for milk.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles
TOXICOLOGY LETTERS, 197(1), 1–6.
Contributors: T. Leavens n , X. Xia n, H. Lee n, N. Monteiro-Riviere n , J. Brooks n & n
author keywords: nC(60); Isolated perfused porcine skin flaps; Pharmacokinetics; In vitro; Nanoparticles; Skin
MeSH headings : Animals; Arteries / metabolism; Colloids; Female; Fullerenes / pharmacokinetics; Immunoglobulin G / metabolism; Models, Animal; Nanoparticles / ultrastructure; Skin / metabolism; Swine; Tissue Distribution; Veins / metabolism
TL;DR:
Based on the apparent volume of distribution, the low extraction during the perfusion, and the high percentage recovery following the washout phase, there was limited distribution of fullerene nanoparticles from the vascular space into the extracellular space and negligible intracellular uptake of nC(60) in this system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2010 conference paper
Formulation effects across veterinary species
Proceedings of the AAVPT/ECVPT/EAVPT Workshop on Bioequivalence Issues in Veterinary Medicine, 135–167.
Event: 2010 AAVPT/EAVPT/ECVPT bioequivalence workshop at Potomac, MD
Source: NC State University Libraries
Added: August 20, 2022
2010 conference paper
In vitro penetration studies of four sunscreen formulations containing titanium and zinc nanoparticles in UVB-damaged skin
[Abstract]. The Toxicologist, 114(S1), 439. https://www.toxicology.org/pubs/docs/Tox/2010Tox.pdf
Event: 49th Annual Meeting and ToxExpo at Salt Lake City, UT on March 7-11, 2010
Source: NC State University Libraries
Added: June 17, 2022
2010 conference paper
In vivo and in vitro assessment of UVB damaged skin with sunscreen formulation containing titanium and zinc nanoparticles
[Abstract]. Proceedings: International Conference and Workshop on Biological Barriers, 114(S1), 73. https://www.toxicology.org/pubs/docs/Tox/2010Tox.pdf
Event: 8th International Conference and Workshop on Biological Barriers at Saarland University, Saarbrücken, Germany on March 21 - April 1, 2010
Source: NC State University Libraries
Added: June 17, 2022
2010 journal article
Intrinsic biological property of colloidal fullerene nanoparticles (nC(60)): Lack of lethality after high dose exposure to human epidermal and bacterial cells
TOXICOLOGY LETTERS, 197(2), 128–134.
Contributors: X. Xia n, N. Monteiro-Riviere n & n
author keywords: Water-soluble fullerenes; Nanotoxicity; Fullerene nanoparticles; Bacteria toxicity; Human epidermal keratinocytes
MeSH headings : Bacillus subtilis / drug effects; Epidermal Cells; Escherichia coli / drug effects; Fullerenes / chemistry; Fullerenes / toxicity; Humans; Keratinocytes / drug effects; Microbial Sensitivity Tests; Nanoparticles / chemistry; Nanoparticles / toxicity; Particle Size; Toxicity Tests
TL;DR:
A novel method for preparing nC60 nanoparticles that does not use THF solvent, but provides nC 60 with an average particle size of 43.8 nm and a yield approximately 100 times higher than the THF method is reported, confirming the prior non-toxic reports when using nC50 prepared with non-THF methods.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2010 journal article
Modelling the effect of mixture components on permeation through skin
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 398(1-2), 28–32.
author keywords: Skin; QSAR; Formulation; Mixture; Permeation; Penetration
MeSH headings : Administration, Cutaneous; Animals; Permeability / drug effects; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / metabolism; Quantitative Structure-Activity Relationship; Skin Absorption / drug effects; Skin Absorption / physiology; Swine
TL;DR:
The findings show that compounds formulated in vehicles with small boiling and melting point gaps will be expected to have higher permeation through skin, compared with compounds in the common skin permeability datasets used in QSAR.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 chapter
New Technologies for Application to Veterinary Medicine
In F. Cunningham, J. Elliott, & P. Lees (Eds.), Comparative and Veterinary Pharmacology (pp. 191–210).
Ed(s): F. Cunningham, J. Elliott & P. Lees
author keywords: Future; Nanotechnology; Pharmacokinetics; Pharmacology; Toxicology; Veterinary medicine
MeSH headings : Animals; Drug Evaluation, Preclinical / methods; Drug Therapy / trends; Drug Therapy / veterinary; Drug Therapy, Computer-Assisted / methods; Drug Therapy, Computer-Assisted / veterinary; Humans; Microfluidics; Nanotechnology / trends; Pharmacogenetics / trends; Pharmacology / trends; Veterinary Medicine / trends
TL;DR:
In this chapter, the potential effects of six transforming technologies on veterinary therapeutics are examined: continued advances in computer technology, microfluidics, nanotechnology, high-throughput screening, control and targeted drug delivery and pharmacogenomics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 13, 2021
2010 conference paper
Novel ingredients: Assuring safety and sustainability
Pet Nutrition- Art or Science?, 30. https://kipdf.com/pet-nutrition-art-or-science_5aca65cc1723dd39f4b51698.html
Event: Waltham International Nutritional Sciences Symposium at Cambridge, UK on September 16-18, 2010
Source: NC State University Libraries
Added: July 22, 2022
2010 conference paper
Pharmacokinetics of melamine in a ruminant model
[Abstract]. The Toxicologist, 114(S1), 247. https://www.toxicology.org/pubs/docs/Tox/2010Tox.pdf
Event: 49th Annual Meeting and ToxExpo at Salt Lake City, UT on March 7-11, 2010
Source: NC State University Libraries
Added: June 17, 2022
2010 journal article
Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats
RESEARCH IN VETERINARY SCIENCE, 90(3), 477–479.
author keywords: Tulathromycin; Goats; Pharmacokinetics; Respiratory disease; Antibiotics
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Disaccharides / administration & dosage; Disaccharides / blood; Disaccharides / pharmacokinetics; Goats / blood; Goats / metabolism; Half-Life; Heterocyclic Compounds / administration & dosage; Heterocyclic Compounds / blood; Heterocyclic Compounds / pharmacokinetics; Injections, Subcutaneous / veterinary; Tandem Mass Spectrometry / veterinary
TL;DR:
The pharmacokinetics of tulathromycin after a single 2.5 mg/kg SC injection in goats were very similar to what has been previously reported in cattle.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 conference paper
Pharmacokinetics of tulathromycin following subcutaneous administration in meat goats
Smith, G., Tell, L., Baynes, R., & Riviere, J. (2010, November 14). Presented at the 26th World Buiatrics Congress, Santiago, Chile.
Event: 26th World Buiatrics Congress at Santiago, Chile
Source: NC State University Libraries
Added: July 22, 2022
2010 journal article
Predicting Skin Permeability from Complex Chemical Mixtures: Dependency of Quantitative Structure Permeation Relationships on Biology of Skin Model Used
TOXICOLOGICAL SCIENCES, 119(1), 224–232.
author keywords: chemical mixtures; percutaneous; dermal absorption; quantitative structure-activity relationships (QSAR); QSPR; skin permeability; in vitro models; pesticide risk assessment
MeSH headings : Animals; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Environmental Pollutants / chemistry; Environmental Pollutants / pharmacokinetics; In Vitro Techniques; Models, Biological; Permeability; Predictive Value of Tests; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption; Sus scrofa
TL;DR:
The findings suggest that a QSPR model for estimating percutaneous absorption as a function of chemical mixture composition is possible and that the nature of the Q SPR model selected is dependent upon the biological level of the in vitro test system used, both findings having significant implications when dermal absorption data are used for in vivo risk assessments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 conference paper
Predicting skin absorption from chemical mixtures utilizing simple quantitative structure permeability relationships and a mixture factor
Riviere, J. E., & Brooks, J. D. (2010, April 7). Presented at the 12th International Conference on Perspectives in Percutaneous Penetration, La Grande Motte, France.
Event: 12th International Conference on Perspectives in Percutaneous Penetration at La Grande Motte, France on April 7-10, 2010
Source: NC State University Libraries
Added: August 20, 2022
2010 conference paper
Predicting skin permeability: Incorporation of chemical mixture effects in simple quantitative structure permeability relationships (QSPeRs). The Toxicologist.114
[Abstract]. The Toxicologist, 114(S1), 107. https://www.toxicology.org/pubs/docs/Tox/2010Tox.pdf
Event: 49th Annual Meeting and ToxExpo at Salt Lake City, UT on March 7-11, 2011
Source: NC State University Libraries
Added: June 17, 2022
2010 conference paper
Prediction of dermal absorption from complex chemical mixtures.
Proceedings: International Conference and Workshop on Biological Barriers, 95.
Event: 8th International Conference and Workshop on Biological Barriers at Saarland University, Saarbrücken, Germany on March 21 - April 1, 2010
Source: NC State University Libraries
Added: June 17, 2022
2010 journal article
Risks associated with melamine and related triazine contamination of food
Emerging Health Threats Journal, 3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3167660/
Source: NC State University Libraries
Added: June 17, 2022
2010 dataset
Riviere and Brooks pig skin flow-through [data file]
Source: NC State University Libraries
Added: August 6, 2018
2010 conference paper
Safety implications of the skin penetration of nanoparticles
Monteiro-Riviere, N. A., Zhang, L., Inman, A. O., Samberg, M. E., Xia, X. R., & Riviere, J. E. (2010, April 7). Presented at the 12th International Conference: Perspectives Percutaneous Penetration, La Grande Motte, France.
Event: 12th International Conference: Perspectives Percutaneous Penetration at La Grande Motte, France on April 7-10, 2010
Source: NC State University Libraries
Added: June 17, 2022
2010 journal article
Surfactant Effects on Skin Absorption of Model Organic Chemicals: Implications for Dermal Risk Assessment Studies
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 73(11), 725–737.
MeSH headings : Administration, Cutaneous; Alkanesulfonic Acids / pharmacology; Animals; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Drug Interactions; Female; Membranes, Artificial; Organic Chemicals / pharmacokinetics; Risk Assessment; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Skin Absorption / physiology; Sodium Dodecyl Sulfate / pharmacology; Solubility; Surface-Active Agents / pharmacology; Surgical Flaps; Swine; Water / chemistry
TL;DR:
The inert three-fiber MCF array predicted absorptive fluxes seen in the ex vivo IPPSF, suggesting lack of any biological effects of the surfactants on skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 chapter
Toxicokinetics: Dermal Exposure and Absorption of Chemicals and Nanomaterials
In C. A. McQueen (Ed.), Comprehensive Toxicology (2nd ed., Vol. 1, pp. 111–122). Oxford: Elsevier.
Ed(s): C. McQueen
Source: NC State University Libraries
Added: June 17, 2022
2010 journal article
Validated models for predicting skin penetration from different vehicles
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 41(5), 612–616.
author keywords: Skin; Penetration; QSAR; Permeation; Formulation; Mixture
MeSH headings : Administration, Cutaneous; Animals; Caffeine / chemistry; Codeine / chemistry; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Models, Chemical; Models, Statistical; Molecular Structure; Octanols / chemistry; Permeability; Pharmaceutical Vehicles / chemistry; Quantitative Structure-Activity Relationship; Skin / metabolism; Skin Absorption / physiology; Swine; Testosterone / chemistry
TL;DR:
The aim of this Quantitative Structure Activity Relationship (QSAR) study was to develop a statistically validated model for the prediction of skin permeability coefficients of compounds dissolved in different vehicles and to help with the elucidation of the mechanisms involved in the permeation process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 chapter
Absorption, Distribution, Metabolism and Elimination
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 11–46). Ames, Iowa: Wiley-Blackwell.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: July 29, 2022
2009 chapter
Aminoglycoside Antibiotics
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 915–944). Ames, Iowa: Wiley-Blackwell.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: July 29, 2022
2009 chapter
Antiseptics/Disinfectants
In J. E. Riviere & M. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 819–834). Ames, Iowa: Wiley-Blackwell.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: July 22, 2022
2009 conference paper
Application of physiological based pharmacokinetic (PBPK) models to predict nanomaterial tissue distribution
Proceedings of the 6th International Key Symposium, 77.
Event: 6th International Key Symposium at Stockholm, Sweden
Source: NC State University Libraries
Added: March 26, 2023
2009 chapter
Chemical Residues in Tissues of Food Animals
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 1453–1462). Ames, Iowa: Wiley-Blackwell.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: July 29, 2022
2009 chapter
Chloramphenicol and Derivatives, Macrolides, Lincosamides, and Miscellaneous Antibiotics.
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 945–982). Ames, Iowa: Wiley-Blackwell.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: July 29, 2022
2009 journal article
Comparison of Quantum Dot Biodistribution with a Blood-Flow-Limited Physiologically Based Pharmacokinetic Model
Nano Letters, 9(2), 794–799.
Contributors: H. Lee n, T. Leavens n, S. Mason n, N. Monteiro-Riviere n & n
MeSH headings : Animals; Hemodynamics; Mice; Models, Biological; Organ Specificity; Pharmacokinetics; Quantum Dots; Rats; Tissue Distribution
TL;DR:
The physiologically based pharmacokinetic model predicted the experimentally observed persistence of QDs in tissues but not early time profiles or different QD biodistribution, suggesting more complex models will be needed to better predict QD biodiversity in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2009 conference paper
Comparison of quantum dot biodistribution with blood flow-limited physiologically based pharmacokinetic model
[Poster]. The Toxicologist, 108(S1), 149, https://www.toxicology.org/pubs/docs/Tox/2009Tox.pdf
Event: 48th Annual Meeting and ToxExpo at Baltimore, MD on March 15-19, 2009
Source: NC State University Libraries
Added: July 29, 2022
2009 chapter
Cutaneous Toxicology
In B. Ballentyne, T. Marrs, & T. Syversen (Eds.), General and Applied Toxicology (3rd ed., pp. 1003–1015). Chichester, West Sussex, UK: Wiley.
Ed(s): B. Ballentyne, T. Marrs & T. Syversen
Source: NC State University Libraries
Added: July 29, 2022
2009 journal article
Dermal Permeation of Biocides and Aromatic Chemicals in Three Generic Formulations of Metalworking Fluids
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 72(13), 832–841.
MeSH headings : Animals; Complex Mixtures / chemistry; Disinfectants / chemistry; Disinfectants / pharmacokinetics; Hydrocarbons, Aromatic / chemistry; Hydrocarbons, Aromatic / pharmacokinetics; Metallurgy; Occupational Exposure; Permeability; Skin Absorption / drug effects; Swine
TL;DR:
Data from this study show that permeation of chemicals is higher in a generic synthetic MWF when compared to a soluble oil MWF, which indicates that a solubleOil MWF may be safer than a syntheticMWF in regard to dermal permeations of chemicals to allow for an increased potential of systemic toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 chapter
Dermatopharmacology: Drugs Acting Locally on the Skin
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 1273–1294). Ames, Iowa: Wiley-Blackwell.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: July 29, 2022
2009 journal article
Determination of the effective dermal penetration barrier pH of porcine skin
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 32(4), 407–410.
MeSH headings : Animals; Hydrogen-Ion Concentration; Linear Models; Models, Biological; Nitrophenols / pharmacokinetics; Organophosphates / pharmacokinetics; Pentachlorophenol / pharmacokinetics; Skin / chemistry; Skin / metabolism; Skin Absorption / physiology; Swine; Triazines / pharmacokinetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 conference paper
Determination of the operational barrier pH of porcine skin
[Poster]. The Toxicologist, 108(S1), 22. https://www.toxicology.org/pubs/docs/Tox/2009Tox.pdf
Event: 48th Annual Meeting and ToxExpo at Baltimore, MD on March 15-19, 2009
Source: NC State University Libraries
Added: July 29, 2022
2009 chapter
Dosage Forms and Veterinary Feed Directives
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 1439–1444). Ames, Iowa: Wiley-Blackwell.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: July 29, 2022
2009 journal article
Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle
Journal of the American Veterinary Medical Association, 234(2), 245–248.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / pharmacokinetics; Cattle; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Female; Infusions, Parenteral / veterinary; Lactation; Mammary Glands, Animal / metabolism; Mastitis, Bovine / drug therapy; Mastitis, Bovine / metabolism; Metabolic Clearance Rate; Milk / chemistry; Prospective Studies; Tylosin / administration & dosage; Tylosin / analogs & derivatives; Tylosin / analysis; Tylosin / pharmacokinetics
TL;DR:
Findings indicated that tilmicosin should not be administered by the intramammary route in lactating dairy cows, and milk from all glands of any cows accidentally treated should be discarded for a minimum of 82 days following intramamsary administration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 chapter
Fluoroquinolones Antimicrobial Drugs
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 983–1012). Ames, Iowa: Wiley-Blackwell.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: July 29, 2022
2009 book review
Genomics in Drug Discovery and Development
(D. Semizarov & E. Blomme, Eds.) [Review of ]. Veterinary Journal, 181(2), 205.
Ed(s): D. Semizarov & E. Blomme
Source: NC State University Libraries
Added: July 22, 2022
2009 conference paper
Impacts of lipophilicity and solvent effects on skin absorption of nanomaterials
US Environmental Protection Agency-Interagency Nanotechnology Implications Grantees Workshop, 4.
Event: US Environmental Protection Agency-Interagency Nanotechnology Implications Grantees Workshop on November 9-10, 2009
Source: NC State University Libraries
Added: August 20, 2022
2009 journal article
Interaction of nanomaterials with skin: Aspects of absorption and biodistribution
Nanotoxicology, 3(3), 188–193.
Contributors: N. Monteiro-Riviere n & n
author keywords: Absorption; biodistribution; nanomaterials; penetration; skin; drug delivery; cosmetics; exposure; nanomedicine
TL;DR:
Research is beginning to be conducted to define the mechanistic framework describing nanomaterials biodistribution using pharmacokinetic models, suggesting that absorption is minimal, yet particle characteristics and species differences exist.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 chapter
Lactam Antibiotics
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 865–894). Ames, Iowa: Wiley-Blackwell.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: July 29, 2022
2009 chapter
Pharmacokinetics
In J. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 47–74). Ames, Iowa: Wiley-Blackwell.
Ed(s): & M. Papich
Source: NC State University Libraries
Added: July 22, 2022
2009 article
Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots (vol 1, pg 26, 2008)
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, Vol. 1, pp. 685–685.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Pharmacology of tetracycline water medication in swine
JOURNAL OF ANIMAL SCIENCE, 87(10), 3179–3186.
author keywords: pharmacokinetics; plasma concentration; swine; tetracycline; water medication
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Biological Availability; Dose-Response Relationship, Drug; Male; Microbial Sensitivity Tests / veterinary; Random Allocation; Swine / metabolism; Tetracycline / administration & dosage; Tetracycline / blood; Tetracycline / pharmacokinetics; Tetracycline / urine
TL;DR:
The study showed that tetracycline oral bioavailability is very small and the dose response curve shows that concentrations of plasma tetrACYcline increase linearly, yet not in a 1 to 1 ratio, to the direct increase in water medication dose.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 book
Safety of Dietary Supplements for Horses, Dogs and Cats
https://nap.nationalacademies.org/catalog/12461/safety-of-dietary-supplements-for-horses-dogs-and-cats
Source: NC State University Libraries
Added: July 29, 2022
2009 journal article
Selection of Appropriate Training Set of Chemicals for Modeling Dermal Permeability Using Uniform Coverage Design
QSAR & COMBINATORIAL SCIENCE, 28(11-12), 1478–1486.
author keywords: Skin absorption; LSER; Diverse chemical selection; QSAR; Modeling; Medicinal chemistry; Toxicology
TL;DR:
Graphical plot of the principal components demonstrated that currently used training set of chemicals have narrow representation of parent dataset whereas the selected training set have appropriate representation in terms of chemical space.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Skin penetration and kinetics of pristine fullerenes (C-60) topically exposed in industrial organic solvents
TOXICOLOGY AND APPLIED PHARMACOLOGY, 242(1), 29–37.
Contributors: X. Xia n, N. Monteiro-Riviere n & n
author keywords: Dermal absorption; Stratum corneum; Nanomaterials; Fullerenes; Solvent effects; Nanotoxicity
MeSH headings : Algorithms; Animals; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Fullerenes / pharmacokinetics; Fullerenes / toxicity; Occupational Exposure / adverse effects; Particle Size; Skin / chemistry; Skin / pathology; Skin Absorption; Solvents / chemistry; Swine
TL;DR:
The solvent effects on the stratum corneum absorption of C60 were consistent with those observed in vivo; in vitro flow-through diffusion cell experiments were conducted in pig skin and fullerenes were not detected in the receptor solutions by 24 h.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2009 chapter
Sulfonamides and potentiated sulfonamides
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 835–864). Ames, Iowa: Wiley-Blackwell.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: July 29, 2022
2009 chapter
Tetracyclines
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 895–914). Ames, Iowa: Wiley-Blackwell.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: July 29, 2022
2009 article
Update on drugs prohibited from extralabel use in food animals
Davis, J. L., Smith, G. W., Baynes, R. E., Tell, L. A., Webb, A. I., & Riviere, J. E. (2009, September 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 235, pp. 528–534.
MeSH headings : Animals; Animals, Domestic; Food / standards; Legislation, Drug; Legislation, Veterinary; United States; Veterinary Drugs
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 conference paper
Uptake of C60 fullerene nanoparticles in isolated perfused porcine skin flaps
[Poster]. The Toxicologist, 108(S1), 149. https://www.toxicology.org/pubs/docs/Tox/2009Tox.pdf
Event: 48th Annual Meeting and ToxExpo at Baltimore, MD on March 15-19, 2009
Source: NC State University Libraries
Added: July 29, 2022
2009 conference paper
Use of a physiologically based pharmacokinetic (PBPK) model to predict tissue disposition in pigs fed melamine
The Toxicologist, 108(S1), 100. https://www.toxicology.org/pubs/docs/Tox/2009Tox.pdf
Event: 48th Annual Meeting and ToxExpo at Baltimore, MD on March 15-19, 2009
Source: NC State University Libraries
Added: August 20, 2022
2009 book
Veterinary Pharmacology and Therapeutics (Chinese edition)
(9th ed.). Ames, IA: Wiley-Blackwell.
Ed(s): & M. Papich
Source: NC State University Libraries
Added: August 20, 2022
2009 chapter
Veterinary Pharmacology: An Introduction to the Discipline
In J. E. Riviere & M. G. Papich (Eds.), Veterinary Pharmacology and Therapeutics (9th ed., pp. 5–10). Ames, Iowa: Wiley-Blackwell.
Ed(s): J. Riviere & M. Papich
Source: NC State University Libraries
Added: July 22, 2022
2008 journal article
A physiologically based pharmacokinetic model linking plasma protein binding interactions with drug disposition
RESEARCH IN VETERINARY SCIENCE, 86(2), 293–301.
author keywords: Physiologically based pharmacokinetic; model (PBPK); Drug-drug interaction; Plasma protein binding; Sulfamethazine; Flunixin meglumine
MeSH headings : Animals; Anti-Infective Agents / blood; Anti-Infective Agents / pharmacokinetics; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Blood Proteins / metabolism; Chromatography, High Pressure Liquid; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / pharmacokinetics; Drug Interactions; Drug Therapy, Combination; Female; Models, Biological; Pharmacokinetics; Protein Binding; Sulfamethazine / blood; Sulfamethazine / pharmacokinetics; Swine / blood; Swine / metabolism; Tissue Distribution
TL;DR:
A physiologically based pharmacokinetic model was developed that links plasma protein binding interactions to drug disposition for SMZ and FLU in swine and predicted a sustained decrease in total drug and a temporary increase in free drug concentration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 article
A solvatochromatic approach to quantifying formulation effects on dermal permeability
SAR AND QSAR IN ENVIRONMENTAL RESEARCH, Vol. 19, pp. 615–630.
author keywords: mixtures; skin; membrane-coated fiber; solvation energy
MeSH headings : Animals; Ethanol / metabolism; Models, Theoretical; Permeability / drug effects; Phenol / metabolism; Skin Physiological Phenomena; Solvents / metabolism; Swine; Toxicology / methods; Water / metabolism
TL;DR:
This research demonstrated that formulation-specific strength coefficients predicted changes in the dermal permeability of phenolic compounds when formulated with commercial metal-working fluid formulations or 50% ethanol and that these effects can be modeled within the context of a linear solvation energy relationship (LSER).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 chapter
Animal skin morphology and dermal absorption
In M. S. Roberts & K. A. Walters (Eds.), Dermal absorption and toxicity assessment (2nd ed., pp. 17–35). New York: Informa Healthcare.
Ed(s): M. Roberts & K. Walters
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Application of linear solvation energy relationships to a custom-made polyaniline solid-phase microextraction fiber and three commercial fibers
JOURNAL OF CHROMATOGRAPHY A, 1188(2), 108–117.
author keywords: polyaniline; solid-phase microextraction; biocides; linear solvation energy relationships; metal core fiber; partition coefficients
MeSH headings : Acrylic Resins / chemistry; Aniline Compounds / chemistry; Dimethylpolysiloxanes / chemistry; Disinfectants / chemistry; Microscopy, Electron, Scanning; Polyethylene Glycols / chemistry; Reproducibility of Results; Solid Phase Microextraction / methods; Thermodynamics
TL;DR:
The LSER study showed that the system properties having the greatest influence on log K were ease of cavity formation and hydrogen bond donating ability, and showed that all four fibers offer a unique environment for solute partitioning.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 conference paper
Comparative aspects of topical delivery
Proceedings of 9th Annual Skin Forum, London, 17.
Event: 9th Annual Skin Forum at London, England, United Kingdom on May 26-27, 2008
Source: NC State University Libraries
Added: July 29, 2022
2008 conference paper
Comparative effects of surfactants (SLS and LAS) on the dermal absorption of a series of compounds in isolated perfused skin
[Abstract]. The Toxicologist, 102(S1), 320. https://www.toxicology.org/pubs/docs/Tox/2008Tox.pdf
Event: 47th Annual Meeting and ToxExpo at Seattle, WA on March 16-20, 2008
Source: NC State University Libraries
Added: July 29, 2022
2008 conference paper
Comparative species differences in dermal absorption. Exploiting the similarities and differences for veterinary and human health applications
Proceedings of the 35th Annual Meeting Controlled Release Society. Presented at the 35th Annual Meeting and Exposition of the Controlled Release Society, New York, NY.
Event: 35th Annual Meeting and Exposition of the Controlled Release Society at New York, NY on July 12-16, 2008
Source: NC State University Libraries
Added: July 29, 2022
2008 conference paper
Disposition of melamine in pigs
[Abstract]. The Toxicologist, 102(S1), 98. https://www.toxicology.org/pubs/docs/Tox/2008Tox.pdf
Event: 47th Annual Meeting and ToxExpo at Seattle, WA on March 16-20, 2008
Source: NC State University Libraries
Added: July 29, 2022
2008 conference paper
Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cows
Proceedings 41st Annual Convention, American Association of Bovine Practitioners, 41, 230.
Event: Proceedings of the Forty-First Annual Conference, American Association of Bovine Practitioners at Charlotte, NC on September 25-27, 2008
TL;DR:
The purpose of this study was to determine the elimination kinetics of tilmicosin in milk following an intramammary infusion so an appropriate proper milk withdrawal interval could be determined.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 20, 2022
2008 journal article
Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic model
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 51(3), 324–331.
author keywords: PBPK; melamine; rat; porcine; meat withdrawal time; feed contaminants
MeSH headings : Animal Feed / adverse effects; Animal Feed / analysis; Animals; Drug Administration Schedule; Drug Residues / analysis; Food Contamination / prevention & control; Male; Meat Products; Models, Biological; Rats; Rats, Inbred F344; Reproducibility of Results; Resins, Synthetic / pharmacokinetics; Swine; Time Factors; Triazines / pharmacokinetics
TL;DR:
A physiologically based pharmacokinetic model for melamine was developed for rats and extrapolated to pigs, providing evidence of the usefulness in species extrapolation over a range of dosing scenarios and can be used to protect the food supply after accidental exposure in the face of little in the target species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 journal article
FARAD digest - Extralabel use of nonsteroidal anti-inflammatory drugs in cattle
Journal of the American Veterinary Medical Association, 232(5), 697–701.
Source: NC State University Libraries
Added: August 6, 2018
2008 conference paper
Ion-Paring Effects on skin absorption of charged nanoparticles
[Abstract]. The Toxicologist, 102(S1), 211. https://www.toxicology.org/pubs/docs/Tox/2008Tox.pdf
Event: 47th Annual Meeting and ToxExpo at Seattle, WA on March 16-20, 2008
Source: NC State University Libraries
Added: July 29, 2022
2008 conference paper
Modeling the effect of mixture components on the skin penetration
Proceedings of 9th Annual Skin Forum, 54.
Event: 9th Annual Skin Forum at London
Source: NC State University Libraries
Added: March 26, 2023
2008 chapter
Percutaneous absorption of complex chemical mixtures
In Marzulli and Maibach's dermatotoxicology (7th ed.) (pp. 63–70). New York: Taylor and Francis.
Source: NC State University Libraries
Added: August 6, 2018
2008 conference paper
Pharmacokinetic modeling and implications of periodicity in arterial extraction of quantum dot nanoparticles
[Abstract]. The Toxicologist, 102(S1), 287. https://www.toxicology.org/pubs/docs/Tox/2008Tox.pdf
Event: 47th Annual Meeting and ToxExpo at Seattle, WA on March 16-20, 2008
Source: NC State University Libraries
Added: July 29, 2022
2008 conference paper
Pharmacokinetics and pharmacokinetic modeling of quantum dots in skin
[Abstract]. The Toxicologist, 102(S1), 406. https://www.toxicology.org/pubs/docs/Tox/2008Tox.pdf
Event: 47th Annual Meeting and ToxExpo at Seattle, WA on March 16-20, 2008
Source: NC State University Libraries
Added: July 29, 2022
2008 conference paper
Pharmacokinetics of nanomaterials: Is it different from chemicals or drugs?
Proceedings Nano-Tox 2008, 24/61.
Event: 2nd International Conference on Nanotoxicology, NANOTOX 2008 at Zurich, Switzerland on September 7-10, 2008
Source: NC State University Libraries
Added: July 29, 2022
2008 review
Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots
[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 1(1), 26–34.
MeSH headings : Animals; Fullerenes / pharmacokinetics; Humans; Metabolic Clearance Rate; Mononuclear Phagocyte System / metabolism; Nanotubes, Carbon; Quantum Dots; Tissue Distribution
TL;DR:
This review focuses on the disposition of carbon based fullerenes and nanotubes, as well as quantum dots (QD) after parenteral administration to primarily rodents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 conference paper
Predicting chemical absorption from complex chemical mixtures
Proceedings of the Atlantic Coast Symposium on the Mathematical Sciences in Biology and Biomedicine. Presented at the Atlantic Coast Symposium on the Mathematical Sciences in Biology and Biomedicine, North Carolina State University, Raleigh, NC.
Event: Atlantic Coast Symposium on the Mathematical Sciences in Biology and Biomedicine at North Carolina State University, Raleigh, NC on April 26-28, 2008
Source: NC State University Libraries
Added: July 29, 2022
2008 journal article
Quantification of chemical mixture interactions modulating dermal absorption using a multiple membrane fiber array
CHEMICAL RESEARCH IN TOXICOLOGY, 21(3), 591–599.
MeSH headings : Algorithms; Chemical Phenomena; Chemistry, Physical; Complex Mixtures / toxicity; Energy Transfer; Ethanol; Membranes, Artificial; Models, Biological; Regression Analysis; Skin Absorption / drug effects; Solvents
TL;DR:
The utility of a three-membrane-coated fiber array to adequately predict changes in dermal permeability when skin is exposed to mixtures containing either a surfactant or a solvent is demonstrated and some insight is provided into the nature of the physiochemical interactions that modulate dermal absorptions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 conference paper
Should physiological-based pharmacokinetic models become de riguer for veterinary antimicrobial studies?
Book of Abstracts: International Conference on Antimicrobial Agents in Veterinary Medicine, 27.
Event: 4th International Conference on Antimicrobial Agents in Veterinary Medicine at Prague, Czech Republic on August 24-28, 2008
Source: NC State University Libraries
Added: December 30, 2022
2008 chapter
Solvent and vehicle effects on the skin
In M. S. Roberts & K. A. Walters (Eds.), Dermal Absorption and Toxicity Assessment (2nd ed., pp. 433–447). New York: Informa Healthcare.
Ed(s): M. Roberts & K. Walters
Source: NC State University Libraries
Added: July 29, 2022
2008 chapter
Solvents and vehicle effects on the skin
In M. S. Roberts & K. A. Walters (Eds.), Dermal absorption and toxicity assessment. (2nd ed.) (pp. 433–447). New York: Informa Healthcare.
Ed(s): M. Roberts & K. Walters
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Sulfamethazine water medication pharmacokinetics and contamination in a commercial pig production unit
JOURNAL OF FOOD PROTECTION, 71(3), 584–589.
MeSH headings : Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / pharmacokinetics; Chromatography, High Pressure Liquid / methods; Consumer Product Safety; Dose-Response Relationship, Drug; Drug Residues / analysis; Food Contamination / analysis; Half-Life; Humans; Metabolic Clearance Rate; Pilot Projects; Sulfamethazine / administration & dosage; Sulfamethazine / pharmacokinetics; Swine / metabolism; Water / chemistry
TL;DR:
Plasma levels in pigs treated with an oral bolus, which is equivalent to the total drug consumed within a 24-h period, achieved therapeutic concentrations and noncompartmental-based pharmacokinetic model parameters were consistent with previously published values in swine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2008 conference paper
The 2007 pet food related toxic nephropathy in dogs and cats.
[Abstract]. The Toxicologist, 102(S1), 129. https://www.toxicology.org/pubs/docs/Tox/2008Tox.pdf
Event: 47th Annual Meeting and ToxExpo at Seattle, WA on March 16-20, 2008
Source: NC State University Libraries
Added: July 29, 2022
2008 conference paper
Use of a multi-fiber approach to quantify chemical mixture interactions modulating dermal absorption
[Abstract]. The Toxicologist, 102(S1), 319. https://www.toxicology.org/pubs/docs/Tox/2008Tox.pdf
Event: 47th Annual Meeting and ToxExpo at Seattle, WA on March 16-20, 2008
Source: NC State University Libraries
Added: July 29, 2022
2008 book
Veterinary pharmacology and therapeutics
Ames, IA: Blackwell Publishing.
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
A system coefficient approach for quantitative assessment of the solvent effects on membrane absorption from chemical mixtures
SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 18(5-6), 579–593.
Contributors: X. Xia n, R. Baynes n , N. Monteiro-Riviere n & n
author keywords: membrane absorption; chemical mixtures; solvent effects; system coefficient approach; solute descriptors
MeSH headings : Absorption; Dimethylpolysiloxanes / chemistry; Dimethylpolysiloxanes / metabolism; Kinetics; Membranes, Artificial; Models, Biological; Models, Chemical; Quantitative Structure-Activity Relationship; Regression Analysis; Silicones / chemistry; Silicones / metabolism; Solvents / chemistry
TL;DR:
A system coefficient approach is proposed for quantitative assessment of the solvent effects on membrane absorption from chemical mixtures using Polydimethylsiloxane membrane-coated fibres and 32 probe compounds to demonstrate the proposed approach.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber array
TOXICOLOGY AND APPLIED PHARMACOLOGY, 221(3), 320–328.
Contributors: X. Xia n, R. Baynes n , N. Monteiro-Riviere n & n
author keywords: skin permeability; predictive model; membrane-coated fiber; distribution coefficients; percutaneous absorption
MeSH headings : Algorithms; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Forecasting; Humans; Membranes, Artificial; Models, Biological; Organic Chemicals / chemistry; Organic Chemicals / pharmacokinetics; Permeability; Pharmaceutical Preparations / chemistry; Pharmaceutical Preparations / metabolism; Reproducibility of Results; Skin / metabolism; Skin Absorption / drug effects; Structure-Activity Relationship
TL;DR:
The MCF array approach is an experimentally based, high throughput approach that provides high prediction confidence and does not require literature data nor molecular structure information in contrast to the existing predictive models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 conference paper
Biodistribution of quantum dot nanoparticles in isolated perfused skin and in flow-through diffusion cells
The 2nd InternationalNanotoxicology Conference, 17.
Event: 2nd InternationalNanotoxicology Conference at San Servolo Servizi,Venice, Italy
Source: NC State University Libraries
Added: March 26, 2023
2007 journal article
Biodistribution of quantum dot nanoparticles in perfused skin: Evidence of coating dependency and periodicity in arterial extraction
NANO LETTERS, 7(9), 2865–2870.
Contributors: H. Lee n, M. Imran n, N. Monteiro-Riviere n , V. Colvin n, W. Yu n & J. Rivlere
MeSH headings : Animals; Arteries / chemistry; Coated Materials, Biocompatible / chemistry; Diffusion; Perfusion; Quantum Dots; Skin / blood supply; Skin / chemistry; Skin Absorption / physiology; Swine; Tissue Distribution
TL;DR:
Both QD had a unique periodicity in arterial extraction never observed with drug infusions, suggesting a potentially important nanomaterial behavior that could affect systemic disposition.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 journal article
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework
Toxicology and Applied Pharmacology, 222(1), 122–128.
MeSH headings : Adaptation, Physiological; Animals; Biology; Dose-Response Relationship, Drug; Humans; Stress, Physiological; Terminology as Topic
TL;DR:
This article offers a set of recommendations that scientists believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2007 article
Current update on drugs for game bird species
Needham, M. L., Webb, A. I., Baynes, R. E., Riviere, J. E., Craigmill, A. L., & Tell, L. A. (2007, November 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 231, pp. 1506–1508.
MeSH headings : Animals; Animals, Domestic; Animals, Wild; Bird Diseases / drug therapy; Birds; Consumer Product Safety; Drug Residues / analysis; Drug Utilization Review; Food Contamination / prevention & control; Legislation, Drug; Legislation, Veterinary; Meat / standards; Species Specificity; United States; United States Food and Drug Administration; Veterinary Drugs / pharmacokinetics; Veterinary Drugs / therapeutic use
TL;DR:
The purpose of this digest is to familiarize veterinarians with the few drugs that are approved for use in game birds and to provide information on the status of ELDU in these species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 conference paper
Custom made pani fiber to assess dermal partitioning and absorption of biocides
The Toxicologist, 96(S1), 433. https://www.toxicology.org/pubs/docs/Tox/2007Tox.pdf
Event: 46th Annual Meeting and ToxExpo at Charlotte, NC on March 25-29, 2007
Source: NC State University Libraries
Added: August 20, 2022
2007 article
Dermal toxicity
VETERINARY TOXICOLOGY: BASIC AND CLINICAL PRINCIPLES, pp. 263–276.
TL;DR:
Skin is an essential and dynamic organ that performs important functions including thermoregulation and preventing insensible water loss and has important metabolic, immunological, and neurosensory properties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 conference paper
Determination of biologically relevant physical chemical parameters of JP-8 hydrocarbons using the membrane coated fiber array
Presented at the AFOSR Jet Fuel Toxicology Workshop, Tucson, AZ.
Event: AFOSR Jet Fuel Toxicology Workshop at Tucson, AZ
Source: NC State University Libraries
Added: August 20, 2022
2007 conference paper
Development of a toxicokinetic model to quantitate quantum dot distribution in isolated perfused skin
Toxicity of Nanomaterials, International Congress of Toxicology, PW11, 251.
Event: ICT XI, 2007: Toxicology: Discovery Serving Society at Montreal, QC, Canada
Source: NC State University Libraries
Added: September 23, 2022
2007 conference paper
Distribution of quantum dot nanoparticles in isolated perfused skin
The Toxicologist, 96(S1), 290. https://www.toxicology.org/pubs/docs/Tox/2007Tox.pdf
Event: 46th Annual Meeting and ToxExpo at Charlotte, NC on March 25-29, 2006
Source: NC State University Libraries
Added: August 20, 2022
2007 conference paper
Estimating safe withdrawal times for drugs given to food-producing animnals using PBPK modeling and Monte Carlo analysis
The Toxicologist, 96(S1), 222. https://www.toxicology.org/pubs/docs/Tox/2007Tox.pdf
Event: 46th Annual Meeting and ToxExpo at Charlotte, NC on March 25-29, 2007
Source: NC State University Libraries
Added: August 20, 2022
2007 conference paper
Incorporation of complex chemical mixture effects into a QSAR model of dermal absorption
The Toxicologist, 96(S1), 433. https://www.toxicology.org/pubs/docs/Tox/2007Tox.pdf
Event: 46th Annual Meeting and ToxExpo at Charlotte, NC on March 25-29, 2007
Source: NC State University Libraries
Added: August 20, 2022
2007 journal article
Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes
JOURNAL OF APPLIED TOXICOLOGY, 28(4), 543–553.
Contributors: A. Inman n, N. Monteiro-Riviere n & n
author keywords: jet fuel; JP-8; skin toxicity; S-8; NF-kappa B; parthenolide; isohelenin; substance P; SB 203580; recombinant human IL-10
MeSH headings : Alkanes / toxicity; Anti-Inflammatory Agents / metabolism; Anti-Inflammatory Agents / pharmacology; Cell Survival / drug effects; Cells, Cultured; Cytokines / metabolism; Humans; Hydrocarbons / toxicity; Imidazoles / pharmacology; Interleukin-10 / metabolism; Irritants / toxicity; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; NF-kappa B / antagonists & inhibitors; NF-kappa B / metabolism; Protein Kinase Inhibitors / pharmacology; Pyridines / pharmacology; Recombinant Proteins / metabolism; Sesquiterpenes / pharmacology; Substance P / metabolism; Time Factors
TL;DR:
This study shows that inhibiting NF‐κB, which appears to play a role in cytokine production in HC‐exposed HEK in vitro, may reduce the inflammatory effect of HC in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2007 chapter
Isolated perfused porcine skin flap
In K. P. Wilhelm, H. Zhai, & H. I. Maibach (Eds.), Marzulli and Maibach’s Dermatotoxicology (7th ed., pp. 347–358). New York: Taylor and Francis.
Ed(s): K. Wilhelm, H. Zhai & H. Maibach
Source: NC State University Libraries
Added: August 20, 2022
2007 journal article
Managing canine obesity: a new therapeutic approach
Journal of Veterinary Pharmacology and Therapeutics, 30(Suppl.).
Source: NC State University Libraries
Added: August 6, 2018
2007 conference paper
Markov chain model for quantitating dermal absorption from complex mixtures
The Toxicologist, 96(S1), 433. https://www.toxicology.org/pubs/docs/Tox/2007Tox.pdf
Event: 46th Annual Meeting and ToxExpo at Charlotte, NC on March 25-27, 2007
Source: NC State University Libraries
Added: August 20, 2022
2007 journal article
Membrane-coated fiber array approach for predicting skin permeability of chemical mixtures from different vehicles
Toxicological Sciences, 99(1), 153–161.
TL;DR:
The results suggested that the experimentally based MCF array approach can be used to predict skin absorption from chemical mixtures in different vehicles or formulations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2007 journal article
Naïve averaged, naïve pooled, and population pharmacokinetics of orally administered marbofloxacin in juvenile harbor seals
Journal of the American Veterinary Medical Association, 230(3), 390–395.
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid / methods; Chromatography, High Pressure Liquid / veterinary; Enzyme Inhibitors / pharmacokinetics; Female; Fluoroquinolones / pharmacokinetics; Male; Metabolic Clearance Rate; Models, Biological; Phoca / blood; Quinolones / pharmacokinetics
TL;DR:
Values of pharmacokinetic variables were similar regardless of the analytic method used and Naïve averaged and naïve pooled analysis appeared to yield a better fit to the population, but nonlinear mixed-effects modeling yielded a betterfit for individual seals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2007 journal article
Partitioning behavior of aromatic components in jet fuel into diverse membrane-coated fibers
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 70(22), 1879–1887.
MeSH headings : 1-Octanol / chemistry; Acrylic Resins / chemistry; Culture Media / chemistry; Dimethylpolysiloxanes / chemistry; Ethanol / chemistry; Humans; Hydrocarbons, Aromatic / chemistry; Hydrocarbons, Aromatic / metabolism; Membranes, Artificial; Models, Biological; Polyethylene Glycols / chemistry; Skin Absorption; Water / chemistry
TL;DR:
It is demonstrated that a single or multiple set of MCF fibers may be used as a surrogate for octanol/water systems and skin to assess partitioning behavior of nine aromatic components frequently formulated with jet fuels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 conference paper
Pharmaco-kinetic modeling of quantum dot nanoparticle biodistribution in isolated perfused skin
The 2nd International Nanotoxicology Conference, 14.
Event: 2nd International Nanotoxicology Conference at San Servolo Servizi,Venice, Italy
Source: NC State University Libraries
Added: March 26, 2023
2007 journal article
Pharmacokinetic-Pharmacodynamic modeling of morphine in dogs.
Journal of Veterinary Internal Medicine, 21(3), 617.
Source: NC State University Libraries
Added: August 20, 2022
2007 journal article
Pharmacokinetics of melamine in pigs following intravenous administration
Food and Chemical Toxicology, 46(3), 1196–1200.
MeSH headings : Animals; Chromatography, High Pressure Liquid; Infusions, Intravenous; Kidney / metabolism; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Swine; Triazines / administration & dosage; Triazines / blood; Triazines / pharmacokinetics
TL;DR:
The pharmacokinetic parameters for melamine obtained in pigs are comparable to the only mammalian study in rats and suggests that melamine is readily cleared by the kidney and there is unlikely to be significant tissue binding.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2007 chapter
Pharmacokinetics of nanomaterials
In Nanotoxicology: characterization, dosing and health effects (pp. 127–152). New York: Informa.
Source: NC State University Libraries
Added: August 6, 2018
2007 conference paper
Pharmacokinetics of skin distribution of quantum dot nanoparticles in isolated perfused skin
The Toxicologist, 96(S1), 290. https://www.toxicology.org/pubs/docs/Tox/2007Tox.pdf
Event: 46th Annual Meeting and ToxExpo at Charlotte, NC on March 25-29, 2007
Source: NC State University Libraries
Added: August 20, 2022
2007 article
Physiologically based pharmacokinetic modeling
VETERINARY TOXICOLOGY: BASIC AND CLINICAL PRINCIPLES, pp. 42–50.
TL;DR:
Physiologically based pharmacokinetic (PBPK) models are mathematical simulations of physiological processes that determine the rate and extent of xenobiotic chemical absorption, distribution, metabolism, and excretion that can be used for predicting internal doses at target organs and tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Predicting dermal permeability of biocides in commercial cutting fluids using a LSER approach
Toxicology Letters, 175(1-3), 34–43.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2007 conference paper
Predicting skin penetration and interaction with JP-8
Presented at the Air Force Office of Scientific Research (AFOSR) Fuels Toxicology Workshop, Tucson, AZ.
Event: Air Force Office of Scientific Research (AFOSR) Fuels Toxicology Workshop at Tucson, AZ
Source: NC State University Libraries
Added: August 20, 2022
2007 conference paper
Predicting skin permeability of molecules from chemical mixtures using an inert membrane-coated fiber array
The Toxicologist, 96(S1), 433. https://www.toxicology.org/pubs/docs/Tox/2007Tox.pdf
Event: 46th Annual Meeting and ToxExpo at Charlotte, NC on March 25-29, 2007
Source: NC State University Libraries
Added: August 20, 2022
2007 article
Prediction of dermal absorption from complex chemical mixtures: incorporation of vehicle effects and interactions into a QSPR framework
SAR AND QSAR IN ENVIRONMENTAL RESEARCH, Vol. 18, pp. 31–44.
author keywords: dermal absorption; chemical mixtures; QSAR; LFER
MeSH headings : Administration, Topical; Animals; Complex Mixtures / administration & dosage; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Dermis / metabolism; In Vitro Techniques; Models, Biological; Models, Chemical; Permeability; Pharmaceutical Vehicles / chemistry; Pharmaceutical Vehicles / pharmacokinetics; Quantitative Structure-Activity Relationship; Skin Absorption; Swine / metabolism; Toxicology / methods
TL;DR:
This work has explored using hybrid QSPR equations describing individual compound penetration based on the molecular descriptors for the compound modified by a mixture factor which accounts for the physicochemical properties of the vehicle/mixture components.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 report
Quantitating the absorption, partitioning and toxicity of hydrocarbon components of JP-8 jet fuel
(Center for Chemical Toxicology Research and Pharmacokinetics Grant No. FA9550-04-1-0376; pp. 1–11,).
Source: NC State University Libraries
Added: August 6, 2018
2007 conference paper
The effect of inhibitors on jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes
The Toxicologist, 96(S1), 429. https://www.toxicology.org/pubs/docs/Tox/2007Tox.pdf
Event: 46th Annual Meeting and ToxExpo at Charlotte, NC on March 25-29, 2007
Source: NC State University Libraries
Added: August 20, 2022
2007 journal article
The future of veterinary therapeutics: A glimpse towards 2030
The Veterinary Journal, 174(3), 462–471.
author keywords: pharmacology; toxicology; future; veterinary medicine
MeSH headings : Animal Diseases / drug therapy; Animals; Pharmacology / trends; Veterinary Drugs; Veterinary Medicine / trends
TL;DR:
The effect of six transforming technologies (continued advances in computer technology, microfluidics, nanotechnology, high-throughput screening, control and targeted drug delivery, pharmacogenomics) on veterinary therapeutics is examined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2007 journal article
Variables influencing interactions of untargeted quantum dot nanoparticles with skin cells and identification of biochemical modulators
NANO LETTERS, 7(5), 1344–1348.
Contributors: J. Ryman-Rasmussen n, n & N. Monteiro-Riviere n
MeSH headings : Amines / metabolism; Carboxylic Acids / metabolism; Cells, Cultured; Nanoparticles; Polyethylene Glycols / metabolism; Quantum Dots; Skin / cytology; Skin / metabolism
TL;DR:
Biochemical inhibitors were identified that attenuate and potentiate QD-NHEK interactions that are important for understanding and controlling interactions of untargeted QD with cells.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 conference paper
A physiologically based pharmacokinetic model of parathion dermal absorption
Toxicological Sciences, 90(S1), 165. https://www.toxicology.org/pubs/docs/Tox/2006Tox.pdf
Event: 45th Annual Meeting of the Society of Toxicology at San Diego, CA on March 5-9, 2006
Source: NC State University Libraries
Added: August 20, 2022
2006 journal article
Application of risk assessment and management principles to the extralabel use of drugs in food-producing animals
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 29(1), 5–14.
MeSH headings : Animals; Decision Trees; Drug Labeling; Drug Residues / adverse effects; Europe; Humans; Legislation, Food; Meat / analysis; Risk Assessment; United States; Veterinary Drugs / administration & dosage; Veterinary Drugs / adverse effects; Veterinary Drugs / analysis
TL;DR:
This review describes how risk assessment principles can be extended to evaluate the risks posed by different classes of extralabel drug use and risk management practices in the United States and Europe are summarized and contrasted to illustrate the application of these principles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 conference paper
Barriers to Drug Absorption – Species Differences
2nd Joint AAPS/AAVPT/CRS Workshop. Presented at the 2nd Joint AAPS/AAVPT/CRS Workshop, San Antonio, TX.
Event: 2nd Joint AAPS/AAVPT/CRS Workshop at San Antonio, TX
Source: NC State University Libraries
Added: March 26, 2023
2006 book
Biological Concepts and Techniques in Toxicology: An Integrated Approach
New York: Taylor Francis.
Ed(s):
Source: NC State University Libraries
Added: August 20, 2022
2006 book
Biological concepts and techniques in toxicology : an integrated approach
TL;DR:
This book presents a risk-based approach to Foods Derived for Genetically Engineered Animals and the Biological Basis of Experimental Toxicity of Jet Propulsion Fuel-8 and discusses Quantitative Structure-Toxicity Relationships Using Chemodescripts and Biodescriptors.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Cluster analysis of the dermal permeability and stratum corneum/solvent partitioning of ten chemicals in twenty-four chemical mixtures in porcine skin
SKIN PHARMACOLOGY AND PHYSIOLOGY, 19(4), 198–206.
author keywords: hierarchical clustering; K-means clustering; skin permeability; stratum corneum partitioning
MeSH headings : Animals; Cluster Analysis; Dermis / metabolism; Epidermis / metabolism; Female; In Vitro Techniques; Permeability; Skin Absorption; Skin Physiological Phenomena; Solubility; Solvents / chemistry; Swine
TL;DR:
The consistent influence of the inclusion of propylene glycol in the solvent system supports the hypothesis that over-saturation due to solvent evaporation has a marked effect on permeability, and the potential of using cluster analysis of large datasets to identify consistent solvent and chemical mixture effects is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 conference paper
Continued studies of nanoparticle interactions with skin
Abstracts of the 2006 U.S. EPA, NSF and NIOSH STAR Nanotechnology Environmental Implications Progress Review, 12–13. Washington, D.C.: U.S. Environmental Protection Agency, Office of Research and Development.
Source: NC State University Libraries
Added: December 10, 2022
2006 book
Dermal Absorption Models in Toxicology and Pharmacology
Boca Raton: Taylor Francis/CRC Press.
Ed(s):
Source: NC State University Libraries
Added: August 20, 2022
2006 book
Dermal absorption models in toxicology and pharmacology
(p. ). Boca Raton: Taylor Francis/CRC Press.
Source: NC State University Libraries
Added: August 6, 2018
2006 chapter
Dermal absorption/toxicity of organophosphates and carbamates
In Toxicology of organophosphates and carbamate pesticides (pp. 411–422).
TL;DR:
A similar conclusion was derived from analysis of how data are used in making pesticide risk assessments, where the authors concluded that the inability to match a specific exposure scenario to available data led to overestimation of absorption, and thus, risk.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2006 chapter
Dermatotoxicology: Computational risk assessment
In Computational toxicology: risk assessment for pharmaceutical and environmental chemicals (pp. 677–692).
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Editorial: A time of change!
Journal of Veterinary Pharmacology and Therapeutics, 29(1), 1.
Source: NC State University Libraries
Added: August 20, 2022
2006 journal article
Exploration of population diversity using probabilistic modelling incorporated into a physiologic based pharmacokinetic model
Journal of Veterinary Pharmacology and Therapeutics, 29(S1), 260–261.
Source: NC State University Libraries
Added: December 10, 2022
2006 article
Extralabel use of penicillin in food animals
Payne, M. A., Craigmill, A., Riviere, J. E., & Webb, A. I. (2006, November 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 229, pp. 1401–1403.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 chapter
In vivo models
In J. E. Riviere (Ed.), Dermal Absorption Models in Toxicology and Pharmacology (pp. 47–68). Boca Raton, FL.: Taylor and Francis.
Ed(s):
Source: NC State University Libraries
Added: August 6, 2018
2006 conference paper
Inert multiple membrane-coated fibers predict dermal absorption of chemicals form mixtures
Toxicological Sciences, 90(S1), 171. https://www.toxicology.org/pubs/docs/Tox/2006Tox.pdf
Event: 45th Annual Meeting of the Society of Toxicology at San Diego, CA on March 5-9, 2006
Source: NC State University Libraries
Added: August 20, 2022
2006 chapter
Introduction and Overview
In J. E. Riviere (Ed.), Biological Concepts and Techniques in Toxicology. (pp. 1–3). New York: Taylor Francis.
Ed(s):
Source: NC State University Libraries
Added: August 6, 2018
2006 conference paper
Multi-walled carbon nanotube exposure in human keratinocytes: proteomic analysis
Witzmann, F. A., Hong, S. M., Inman, A. O., Riviere, J. E., Niemanich, R. J., Wang, Y. Y., & Monteiro-Riviere, N. A. (2006, February). Presented at the First International Conference on Nanotoxicology: Biomedical Aspects, Miami, FL.
Event: First International Conference on Nanotoxicology: Biomedical Aspects at Miami, FL. on February 14, 2006
Source: NC State University Libraries
Added: July 29, 2022
2006 conference paper
Partitioning behavior of selective aromatic and aliphatic jet fuel components across membranes
Toxicological Sciences, 90(S1), 171. https://www.toxicology.org/pubs/docs/Tox/2006Tox.pdf
Event: 45th Annual Meeting of the Society of Toxicology at San Diego, CA on March 5-9, 2006
Source: NC State University Libraries
Added: August 20, 2022
2006 journal article
Penetration of intact skin by quantum dots with diverse physicochemical properties
TOXICOLOGICAL SCIENCES, 91(1), 159–165.
Contributors: J. Ryman-Rasmussen n, n & N. Monteiro-Riviere n
author keywords: quantum dots; semiconductor nanocrystals; skin; nanomaterials; nanotoxicology
MeSH headings : Animals; Female; Microscopy, Confocal; Quantum Theory; Skin Absorption; Spectrometry, Fluorescence; Swine
TL;DR:
It is shown that quantum dots of different sizes, shapes, and surface coatings can penetrate intact skin at an occupationally relevant dose within the span of an average-length work day, suggesting that skin is surprisingly permeable to nanomaterials with diverse physicochemical properties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 chapter
Percutaneous absorption of chemical mixtures
In Dermal absorption models in toxicology and pharmacology (pp. 281–301). New York: Taylor and Francis / CRC Press.
Source: NC State University Libraries
Added: August 6, 2018
2006 chapter
Perfused skin models
In J. E. Riviere (Ed.), Dermal Absorption Models in Toxicology and Pharmacology (pp. 27–45). Boca Raton, FL.: Taylor and Francis.
Ed(s):
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Pharmacokinetic modeling of dermal absorption
Journal of Veterinary Pharmacology and Therapeutics, 29(S1), 244–245.
Source: NC State University Libraries
Added: August 6, 2018
2006 conference paper
Pharmacokinetic modeling of dermal absorption
Journal of Veterinary Pharmacology and Therapeutics, 29(S1), 244–245.
Source: NC State University Libraries
Added: August 20, 2022
2006 journal article
Pharmacokinetics of flunixin meglumine in swine after intravenous dosing
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 29(5), 437–440.
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Clonixin / analogs & derivatives; Clonixin / blood; Clonixin / metabolism; Clonixin / pharmacokinetics; Half-Life; Injections, Intravenous; Metabolic Clearance Rate; Protein Binding; Swine
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Regression method of the hydrophobicity for determining octanol/water partition ruler approach coefficients of very hydrophobic compounds
CHEMOSPHERE, 66(6), 1086–1093.
author keywords: octanol/water partition coefficient; hydrophobic compound; indirect method; regression method; hydrophobicity
MeSH headings : Calibration; Dimethylpolysiloxanes; Hydrophobic and Hydrophilic Interactions; Kinetics; Methanol; Models, Chemical; Octanols; Polychlorinated Biphenyls / chemistry; Regression Analysis; Silicones; Water
TL;DR:
A regression method was developed for the hydrophobicity ruler approach, which is an indirect method for determining the octanol/water partition coefficients of very hydrophobic compounds by regression of the absorption data sampled before the partition equilibrium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Skin penetration of fullerene substituted amino acids and their interactions with human epidermal keratinocytes
Toxicological Sciences, 90(S1), 168.
Source: NC State University Libraries
Added: August 20, 2022
2006 conference paper
Skin penetration, cellular uptake, cytotoxicity, and inflammatory potential of quantum dots
Toxicological Sci, 90(S1), 168, https://www.toxicology.org/pubs/docs/Tox/2006Tox.pdf
Event: 45th Annual Meeting of the Society of Toxicology at San Diego, CA
Source: NC State University Libraries
Added: August 20, 2022
2006 conference paper
Skin penetration, cellular uptake, cytotoxicity, proteomic analyses, and inflammatory potential of fullerenes, multi-walled carbon nanotubes and quantum dots
Monteiro-Riviere, N. A., Yang, J., Inman, A. O., Ryman-Rasmussen, J., Barron, A. R., Wang, Y. Y., … Riviere, J. E. (2006, January). Presented at the First International Conference on Nanotoxicology: Biomedical Aspects, Miami, FL.
Event: First International Conference on Nanotoxicology: Biomedical Aspects at Miami, FL. on January 31, 2006
Source: NC State University Libraries
Added: July 29, 2022
2006 journal article
Skin penetration, cytotoxicity, proteomic analyses, and inflammatory potential of nanomaterials; fullerenes, multi-walled carbon nanotubes and quantum dots
Journal of Veterinary Pharmacology and Therapeutics, 29(Sup. 1), 196–197.
Source: NC State University Libraries
Added: August 6, 2018
2006 conference paper
Skin penetration, cytotoxicity, proteomic analysis, and inflammatory potential of nanomaterials: Fullerines, multi-walled carbon nanotubes and quantum dots
Journal of veterinary pharmacology and therapeutics, 29(S1), 196–197,
Source: NC State University Libraries
Added: August 20, 2022
2006 journal article
Surface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytes
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 127(1), 143–153.
Contributors: J. Ryman-Rasmussen n, n & N. Monteiro-Riviere n
MeSH headings : Cells, Cultured; Drug Delivery Systems / adverse effects; Epidermis; Humans; Interleukin-1 / metabolism; Interleukin-10 / metabolism; Interleukin-6 / metabolism; Interleukin-8 / metabolism; Irritants / toxicity; Keratinocytes; Microscopy, Confocal; Microscopy, Electron, Scanning; Nanoparticles / administration & dosage; Nanoparticles / toxicity; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Human epidermal keratinocytes (HEKs) were used to assess if QDs with different surface coatings would cause differential effects on HEK cytotoxicity, proinflammatory cytokine release, and cellular uptake, and data indicate that QD surface coating is a primary determinant of cytot toxicity and immunotoxicity in HEKs, which is consistent across size.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 book
Tabulation of FARAD Comparative and Veterinary Pharmacokinetic Data
Ames, IA: Blackwell Publishing.
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release
ARCHIVES OF TOXICOLOGY, 80(8), 508–523.
Contributors: J. Yang *, C. Lee*, N. Monteiro-Riviere n , n, C. Tsang* & C. Chou *
author keywords: hydrocarbon mixtures; jet fuels; keratinocyte; cytotoxicity; interleukin-8
MeSH headings : Aviation; Cell Survival / drug effects; Cells, Cultured; Complex Mixtures / chemistry; Complex Mixtures / toxicity; Fuel Oils / analysis; Fuel Oils / toxicity; Humans; Hydrocarbons, Aromatic / chemistry; Hydrocarbons, Aromatic / toxicity; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Structure-Activity Relationship
TL;DR:
The results indicated that when hydrocarbons were mixed, HEK mortality and IL-8 release were not all predictable by their individual ability affecting these two parameters, and the mixture effects must be considered when evaluating jet fuel toxicity to HEK.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Trace analysis of fullerenes in biological samples by simplified liquid-liquid extraction and high-performance liquid chromatography
JOURNAL OF CHROMATOGRAPHY A, 1129(2), 216–222.
Contributors: X. Xia n, N. Monteiro-Riviere n & n
author keywords: fullerenes; nanoparticles; colloidal nanoparticles; emulsion; liquid-liquid extraction; solvent evaporation; dermal absorption
MeSH headings : Chromatography, High Pressure Liquid / methods; Emulsions / chemistry; Fullerenes / analysis; Fullerenes / chemistry; Nanoparticles / chemistry; Reproducibility of Results; Solvents / chemistry
TL;DR:
A simplified LLE method was developed for high throughput while preserved the advantages of the traditional LLE and was used for trace analysis of fullerenes in protein containing media and tape-stripped skin samples.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2006 journal article
Trace analysis of nano C60 in biological media by liquid-liquid extraction and high performance liquid chromatography
Toxicological Sciences, 90(S1), 167.
Source: NC State University Libraries
Added: August 20, 2022
2006 journal article
Use of probabilistic modeling within a physiologically based pharmacokinetic model to predict sulfamethazine residue withdrawal times in edible tissues in swine
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 50(7), 2344–2351.
MeSH headings : Animals; Animals, Domestic / metabolism; Drug Residues / pharmacokinetics; Female; Legislation, Drug; Legislation, Veterinary; Meat; Models, Statistical; Monte Carlo Method; Predictive Value of Tests; Sulfamethazine / administration & dosage; Sulfamethazine / pharmacokinetics; Swine / metabolism; Time Factors; Tissue Distribution; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
Probabilistic modeling techniques incorporated into a physiologically based pharmacokinetic (PBPK) model were used to predict the amounts of sulfamethazine residues in edible tissues in swine to calculate the withdrawal time by using the tolerance limit algorithm designed by FDA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 conference paper
A mechanistic mathematical model to predict the transfer of systemically administered drugs from plasma to milk
Proceeding AAVPT Biennial Symposium. Presented at the American Academy of Veterinary Pharmacology and Therapeutics (AAVPT) 14th Biennial Symposium.
Event: American Academy of Veterinary Pharmacology and Therapeutics (AAVPT) 14th Biennial Symposium on May 16-18, 2005
Source: NC State University Libraries
Added: August 20, 2022
2005 conference paper
A novel system coefficient approach for quantitative assessment of dermal absorption from chemical mixtures by using the membrane-coated fiber technique
The Toxicologist, 84(S1), 450. https://www.toxicology.org/pubs/docs/Tox/2005Tox.pdf
Event: 44th Annual Meeting & ToxExpo at New Orleans, LA on March 6-10, 2005
Source: NC State University Libraries
Added: August 20, 2022
2005 conference paper
A physiologically based pharmacokinetic model of fenthion absorption through porcine skin in a flow-through cell
Proceeding AAVPT Biennial Symposium. Presented at the American Academy of Veterinary Pharmacology and Therapeutics (AAVPT) 14th Biennial Symposium, Rockville, MD.
Event: American Academy of Veterinary Pharmacology and Therapeutics (AAVPT) 14th Biennial Symposium at Rockville, MD on May 16-18, 2005
Source: NC State University Libraries
Added: August 20, 2022
2005 journal article
A physiologically based pharmacokinetic model of organophosphate dermal absorption
TOXICOLOGICAL SCIENCES, 89(1), 188–204.
Contributors: D. Merwe n, J. Brooks n, R. Gehring n, R. Baynes n , N. Monteiro-Riviere n & n
author keywords: dermal absorption; PBPK model; parathion; fenthion; methyl parathion
MeSH headings : Administration, Cutaneous; Animals; Dose-Response Relationship, Drug; Fenthion / pharmacokinetics; In Vitro Techniques; Insecticides / pharmacokinetics; Methyl Parathion / pharmacokinetics; Models, Biological; Organothiophosphorus Compounds / pharmacokinetics; Parathion / pharmacokinetics; Risk Assessment; Skin / metabolism; Skin Absorption / physiology; Skin Physiological Phenomena; Solubility; Swine
TL;DR:
The similarity between the overall shapes of the experimental and model-predicted flux/time curves and the successful simulation of altered system conditions for this series of small, lipophilic compounds indicated that the absorption processes were successfully simulated important aspects of dermal absorption in flow-through cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 conference paper
A physiologically based pharmacokinetic model of sulfamethazine in swine applied to tissue residues
Proceedings of the American Academy of Veterinary Pharmacology and Therapeutics (AAVPT) Biennial Symposium. Presented at the American Academy of Veterinary Pharmacology and Therapeutics (AAVPT) Biennial Symposium, Rockville, MD.
Event: American Academy of Veterinary Pharmacology and Therapeutics (AAVPT) Biennial Symposium at Rockville, MD on May 18, 2005
Source: NC State University Libraries
Added: October 21, 2022
2005 article
Aminoglycoside residues in food of animal origin
Gehring, R., Haskell, SR, Payne, M. A., Craigmill, A. L., Webb, A. I., & Riviere, J. E. (2005, July 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 227, pp. 63–66.
MeSH headings : Aminoglycosides / analysis; Aminoglycosides / pharmacokinetics; Animals; Anti-Bacterial Agents / analysis; Anti-Bacterial Agents / pharmacokinetics; Consumer Product Safety; Drug Residues / analysis; Food Contamination / analysis; Legislation, Drug; Legislation, Veterinary; Meat / analysis; United States; Veterinary Drugs / adverse effects; Veterinary Drugs / therapeutic use
TL;DR:
The purpose of this digest is to give an overview of the pharmacokinetics and other properties of the aminoglycosides that contribute to these residues so that practitioners can better understand the food-safety risks of using these antimicrobials in foodproducing animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 article
Antidotes in food animal practice
Haskell, S. R. R., Payne, M., Webb, A., Riviere, J., & Craigmill, A. L. (2005, March 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 226, pp. 884–887.
MeSH headings : Animal Husbandry; Animals; Animals, Domestic; Antidotes / administration & dosage; Consumer Product Safety; Drug Approval; Drug Compounding / veterinary; Drug Residues / analysis; Humans; Legislation, Veterinary; Meat / standards; United States; United States Food and Drug Administration; Veterinary Drugs / administration & dosage; Veterinary Drugs / adverse effects; Veterinary Medicine / methods
TL;DR:
This Food Animal Residue Avoidance Databank (FARAD) Digest provides a summary of regulatory and scientific information regarding the most commonly recommended antidotes used in food animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Comparative in vivo toxicity of topical JP-8 jet fuel and its individual hydrocarbon components: Identification of tridecane and tetradecane as key constituents responsible for dermal irritation
TOXICOLOGIC PATHOLOGY, 33(2), 258–266.
Contributors: F. Muhammad n, N. Monteiro-Riviere n & n
author keywords: hydrocarbons; skin; in vivo irritation; jet fuel; ultrastructure; pathology
MeSH headings : Administration, Topical; Alkanes / toxicity; Animals; Epidermis / drug effects; Epidermis / ultrastructure; Erythema / chemically induced; Erythema / pathology; Hydrocarbons / chemistry; Hydrocarbons / toxicity; Irritants / chemistry; Irritants / toxicity; Kerosene / toxicity; Swine
TL;DR:
Ulastructural studies depicted that jet fuel HC-induced cleft formation within intercellular lipid lamellar bilayers of the stratum corneum was proportional to the length of in vivo HC exposures and revealed that specific HCs (tridecane and tetradecane) might be the key constituents responsible for jet fuel-induced skin irritation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentrations in swine and application to prediction of violative residues in edible tissues
AMERICAN JOURNAL OF VETERINARY RESEARCH, 66(10), 1686–1693.
MeSH headings : Adipose Tissue / metabolism; Animals; Injections, Intravenous / veterinary; Kidney / metabolism; Liver / metabolism; Models, Biological; Muscle, Skeletal / metabolism; Sulfamethazine / administration & dosage; Sulfamethazine / blood; Sulfamethazine / pharmacokinetics; Swine / metabolism; Tissue Distribution
TL;DR:
Use of this model enabled accurate prediction of sulfamethazine pharmacokinetics in swine and has applications for food safety and prediction of drug residues in edible tissues.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
Effect of JP-8 jet fuel exposure on protein expression in human keratinocyte cells in culture
TOXICOLOGY LETTERS, 160(1), 8–21.
Contributors: F. Witzmann *, N. Monteiro-Riviere n , A. Inman n, M. Kimpel*, N. Pedrick*, H. Ringham*, n
author keywords: jet fuel; keratinocyte; mass spectrometry; proteomics; toxicity; two-dimensional electrophoresis
MeSH headings : Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; Humans; Hydrocarbons / pharmacology; Hydrocarbons / toxicity; Image Processing, Computer-Assisted; Interleukin-8 / biosynthesis; Keratinocytes / drug effects; Keratinocytes / metabolism; Occupational Exposure; Peptide Mapping; Protein Biosynthesis / drug effects; Proteome / biosynthesis; Proteome / drug effects; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
TL;DR:
To examine the effect of JP-8 administration on the human epidermal keratinocyte (HEK) proteome, a two-dimensional electrophoretic approach combined with mass spectrometric-based protein identification and Peptide mass fingerprint identification of effected proteins revealed a variety of functional implications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 conference paper
Effect of acute and chronic exposure to the cleanser, trichloroethylene, on the dermal absorption of the biocide triazine
The Toxicologist, 84(S1), 445–446. https://www.toxicology.org/pubs/docs/Tox/2005Tox.pdf
Event: 44th Annual Meeting & ToxExpo at New Orleans, LA on March 6-10, 2005
Source: NC State University Libraries
Added: August 20, 2022
2005 article
Effect of formulation and route of administration on tissue residues and withdrawal times
KuKanich, B., Gehring, R., Webb, A. I., Craigmill, A. L., & Riviere, J. E. (2005, November 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 227, pp. 1574–1577.
MeSH headings : Absorption; Animals; Dose-Response Relationship, Drug; Drug Administration Routes / veterinary; Drug Residues / analysis; Meat / analysis; Meat / standards; Tissue Distribution; United States; Veterinary Drugs / pharmacokinetics
TL;DR:
A more thorough review of WDTs and tolerances and how they are determined has been published.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Effect of in vivo jet fuel exposure on subsequent in vitro dermal absorption of individual aromatic and aliphatic hydrocarbon fuel constituents
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 68(9), 719–737.
Contributors: F. Muhammad n, N. Monteiro-Riviere n , R. Baynes n & n
MeSH headings : Animals; Female; Hydrocarbons / pharmacokinetics; Hydrocarbons / pharmacology; Permeability / drug effects; Skin Absorption / drug effects; Swine
TL;DR:
It is suggested that the preexposure of skin to jet fuel enhances the subsequent in vitro percutaneous absorption of HC, so single-dose absorption data for jet fuel HC from naive skin may not be optimal to predict the toxic potential for repeated exposures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 conference paper
Effect of in vivo jet fuel exposure on subsequent in vitro dermal absorption of individual aromatic and aliphatic hydrocarbons
The Toxicologist, 84(S1), 446. https://www.toxicology.org/pubs/docs/Tox/2005Tox.pdf
Event: 44th Annual Meeting & ToxExpo at New Orleans, LA on March 6-10, 2005
Source: NC State University Libraries
Added: August 20, 2022
2005 journal article
Extralabel intramammary use of drugs in dairy cattle
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 226(12), 1994–1996.
TL;DR:
It is extremely important for vetinarians to maintain good records and follow extended withdrawal intervals when using intramam-mary administration of drugs in an extralabel manner to ensure food safety andavoid residue violations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 conference paper
Hierarchical QSAR (HiQSAR) approach to predicting dermal penetration
Proceedings, American Chemical Society Meeting (Division of Computers in Chemistry). Presented at the American Chemical Society 229th National Meeting, San Diego, CA.
Event: American Chemical Society 229th National Meeting at San Diego, CA on March 13-17, 2005
Source: NC State University Libraries
Added: August 20, 2022
2005 journal article
Membrane uptake kinetics of jet fuel aromatic hydrocarbons from aqueous solutions studied by a membrane-coated fiber technique
TOXICOLOGY MECHANISMS AND METHODS, 15(4), 307–316.
Contributors: X. Xia n, R. Baynes n , N. Monteiro-Riviere n & n
author keywords: uptake kinetics; membrane-coated fiber; partition coefficient; jet fuel; aromatic hydrocarbons
TL;DR:
The results suggest that the MCF technique can detect subtle differences in molecular interactions of the two group derivatives between the two membrane/water systems and may be used to study the absorption and permeation properties of closely related compounds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2005 journal article
Multivariate meta-analysis of pharmacokinetic studies of ampicillin trihydrate in cattle
AMERICAN JOURNAL OF VETERINARY RESEARCH, 66(1), 108–112.
MeSH headings : Ampicillin / pharmacokinetics; Animals; Anti-Bacterial Agents / pharmacokinetics; Cattle / metabolism; Cluster Analysis; Multivariate Analysis
TL;DR:
Meta-analysis was successful in detecting a potential subpopulation of cattle for which factors that explained differences in pharmacokinetic parameters could be identified.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 conference paper
Nanotube dispersal in human keratinoctye cell culture using surfactants
The Toxicologist, 84(S1), 447–448. https://www.toxicology.org/pubs/docs/Tox/2005Tox.pdf
Event: 44th Annual Meeting & ToxExpo at New Orleans, LA on March 6-10, 2005
Source: NC State University Libraries
Added: August 20, 2022
2005 conference paper
Overview of JP-8 constituent hydrocarbon interaction with skin: Determination of physical-chemical properties used to predict dermal absorption and continued studies on hydrocarbon-induced epidermal toxicity
AFOSR Jet Fuel Toxicology Workshop. Presented at the AFOSR Jet Fuel Toxicology Workshop, Tucson, AZ.
Event: AFOSR Jet Fuel Toxicology Workshop at Tucson, AZ
Source: NC State University Libraries
Added: March 26, 2023
2005 chapter
Percutaneous absorption of chemical mixtures
In Percutaneous absorption: drugs, cosmetics, mechanisms, methodology (4th ed.) (pp. 155–163). New York: Taylor and Francis / Marcel Dekker.
Source: NC State University Libraries
Added: August 6, 2018
2005 conference paper
Pharmacokinetic and allometric techniques used by FARAD to estimate extended withdrawal times
Proceedings of the American Academy of Veterinary Pharmacology and Therapeutics (AAVPT) 14th Biennial Symposium, 14.
Event: American Academy of Veterinary Pharmacology and Therapeutics (AAVPT) 14th Biennial Symposium at Rockville, MD
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazine
TOXICOLOGY LETTERS, 159(3), 252–260.
author keywords: triazine; skin; TCE; cutting fluids
MeSH headings : Animals; Diffusion Chambers, Culture; Female; In Vitro Techniques; Metallurgy; Permeability; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Swine; Triazines / pharmacokinetics; Trichloroethylene / pharmacology
TL;DR:
It is demonstrated that TCE pre-treatment can significantly alter the dermal permeability to triazine, and workers who are chronically exposed to this or similar cleansers may be at increased risk of absorbing related skin irritants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 journal article
Predicting skin permeability from complex chemical mixtures
TOXICOLOGY AND APPLIED PHARMACOLOGY, 208(2), 99–110.
author keywords: QSPeR; QSAR; dermal absorption; risk assessment; chemical mixtures
MeSH headings : Algorithms; Animals; Chemical Phenomena; Chemistry, Physical; Complex Mixtures / chemistry; Complex Mixtures / pharmacokinetics; Complex Mixtures / toxicity; Diffusion Chambers, Culture; Hydrogen / chemistry; In Vitro Techniques; Linear Models; Models, Statistical; Pharmaceutical Preparations / metabolism; Pharmaceutical Vehicles; Quantitative Structure-Activity Relationship; Refractometry; Risk Assessment; Skin Absorption / physiology; Swine
TL;DR:
The importance of these findings is that there is an approach whereby the effects of a mixture on dermal absorption of a penetrant of interest can be quantitated in a standard QSPeR model if physicochemical properties of the mixture are also incorporated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 conference paper
Predicting skin permeability from complex chemical mixtures
Proceedings of the Contemporary Concepts in Toxicology: Building the Scientific Foundation for Mixture Joint Toxicity and Risk Assessment. Presented at the Contemporary Concepts in Toxicology (CCT): Charting the Future: Building the Scientific Foundation for Mixtures Joint Toxicity and Risk Assessment, Atlanta, GA.
Event: Contemporary Concepts in Toxicology (CCT): Charting the Future: Building the Scientific Foundation for Mixtures Joint Toxicity and Risk Assessment at Atlanta, GA on February 16-17, 2005
Source: NC State University Libraries
Added: August 20, 2022
2005 conference paper
Prediction of dermal absorption of chemical mixtures using both penetrant and mixture component properties in a hybrid quantitative structure permeability relationship (QSPR)
The Toxicologist, 84(S1), 450. https://www.toxicology.org/pubs/docs/Tox/2005Tox.pdf
Event: 44th Annual Meeting & ToxExpo at New Orleans, LA on March 6-10, 2005
Source: NC State University Libraries
Added: August 20, 2022
2005 conference paper
Proteomic analysis of JP-8 jet fuel exposure in human keratinocyte cell culture
The Toxicologist, 84(S1), 447, https://www.toxicology.org/pubs/docs/Tox/2005Tox.pdf
Event: 44th Annual Meeting & ToxExpo at New Orleans, LA on March 6-10, 2005
Source: NC State University Libraries
Added: August 20, 2022
2005 conference paper
Proteomic analysis of nanoparticle exposure in human keratinocyte cell culture
The Toxicologist, 84(S1), 447. https://www.toxicology.org/pubs/docs/Tox/2005Tox.pdf
Event: 44th Annual Meeting & ToxExpo at New Orleans, LA on March 6-10, 2005
Source: NC State University Libraries
Added: August 20, 2022
2005 conference paper
Quantification of Mixture Interactions on Dermal Permeability – A Solvatochromatic Approach
The Toxicologist, 84(S1), 449–450. https://www.toxicology.org/pubs/docs/Tox/2005Tox.pdf
Event: 44th Annual Meeting & ToxExpo at New Orleans, LA on March 6-10, 2005
Source: NC State University Libraries
Added: August 20, 2022
2005 conference paper
The pig as a model for human skin research
Swine in Biomedical Research: Update on Animal Models. Sinclair Research Center. 56th AALAS National Meeting, 56, 17–22.
Source: NC State University Libraries
Added: August 6, 2018
2005 conference paper
Theoretical descriptor based QSARs in predicting skin penetration of JP8 chemicals
AFOSR Jet Fuel Toxicology Workshop. Presented at the AFOSR Jet Fuel Toxicology Workshop, Tucson, AZ.
Event: AFOSR Jet Fuel Toxicology Workshop at Tucson, AZ
Source: NC State University Libraries
Added: March 26, 2023
2005 chapter
Transdermal peptide delivery using electroporation
In L. M. Sanders & R. W. Hendren (Eds.), Protein delivery: Physical systems (pp. 213–238).
Ed(s): . L. M. Sanders & R. Hendren
MeSH headings : Administration, Cutaneous; Animals; Biological Transport; Calcitonin / administration & dosage; Electroporation / adverse effects; Gonadotropin-Releasing Hormone / administration & dosage; Insulin / administration & dosage; Lipid Bilayers / chemistry; Neurotensin / administration & dosage; Peptides / administration & dosage; Skin / metabolism; Swine; Vasopressins / administration & dosage
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2004 journal article
A Compartment Model for the Membrane-Coated Fiber Technique Used for Determining the Absorption Parameters of Chemicals into Lipophilic Membranes
Pharmaceutical Research, 21(8), 1345–1352.
Contributors: X. Xia n, R. Baynes n , N. Monteiro-Riviere n & n
author keywords: absorption kinetics; lipophilic membrane; membrane-coated fiber; partition coefficient; uptake rate constant
MeSH headings : Absorption; Gas Chromatography-Mass Spectrometry / methods; Kinetics; Membranes, Artificial; Models, Biological; Permeability; Pesticides / analysis; Pesticides / chemistry; Reproducibility of Results; Solubility
TL;DR:
A compartment model for the membrane-coated fiber (MCF) technique for determining the absorption parameters of chemicals into lipophilic membranes can describe the absorption kinetics of the MCF technique and is a useful tool for the determination of the partition coefficients of Lipophilic compounds when it takes too long for them to reach permeation equilibrium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2004 conference paper
A comparative investigation of the effects of water, ethanol, and water/ethanol mixtures on chemical partitioning into porcine stratum corneum and permeability in porcine skin
The Toxicologist, 78(S1), 326.
Event: Society of Toxicology 43rd Annual Meeting at Baltimore, MD on March 15-21, 2004
Source: NC State University Libraries
Added: September 23, 2022
2004 conference paper
A hierarchical QSAR (HiQSAR) approach to predict dermal penetration of JP-8 chemicals
AFOSR Jet Fuel Toxicology Workshop. Presented at the AFOSR Jet Fuel Toxicology Workshop, Tucson, AZ.
Event: AFOSR Jet Fuel Toxicology Workshop at Tucson, AZ
Source: NC State University Libraries
Added: March 26, 2023
2004 journal article
A web-based decision support system to estimate extended withdrawal intervals
COMPUTERS AND ELECTRONICS IN AGRICULTURE, 44(2), 145–151.
author keywords: withdrawal times; extralabel drug use; drug residues; veterinary medicine
TL;DR:
A web-based application was developed to facilitate the calculation of extended withdrawal intervals based on information in the databases maintained by members of the Food Animal Residue Avoidance Databank (FARAD) and using the Extrapolated Withdrawal Interval Estimator (EWE) algorithm.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Characterization of polyacrylate membrane-coated fibers used in chemical absorption studies with programmed thermal treatment and FT-IR microscopy
ANALYTICAL CHEMISTRY, 76(14), 4245–4250.
Contributors: X. Xia n, R. Baynes n , N. Monteiro-Riviere n & n
TL;DR:
The anhydride formation explained the absorption property of PA MCFs in GC applications where they must be preconditioned at 300 degrees C and suggested that a PA fiber does not preferably absorb polar compounds (with permanent dipole moment); instead, it absorbs preferably aromatic compounds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 journal article
Comparative mixture effects of JP-8(100) additives on the dermal absorption and disposition of jet fuel hydrocarbons in different membrane model systems
TOXICOLOGY LETTERS, 150(3), 351–365.
author keywords: JP-8(100); mixture effects; comparative absorption; membrane models
MeSH headings : Administration, Topical; Alkanes / pharmacokinetics; Animals; Carbon Radioisotopes; Cell Membrane Permeability / drug effects; Dimethylpolysiloxanes / chemistry; Hydrocarbons / pharmacokinetics; In Vitro Techniques; Membranes, Artificial; Models, Biological; Naphthalenes / pharmacokinetics; Silicones / chemistry; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Swine
TL;DR:
The observations demonstrate that the single membrane system may not be suitable for the final prediction of complex additive interactions in jet fuels and rather a combination of different membrane systems may provide the insight to elucidate the possible mechanism for additive interactions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Comparative studies on the effects of water, ethanol and water/ethanol mixtures on chemical partitioning into porcine stratum corneum and silastic membrane
TOXICOLOGY IN VITRO, 19(1), 69–77.
author keywords: dermal absorption; partitioning; chemical mixtures
MeSH headings : Animals; Epidermis / drug effects; Epidermis / metabolism; Ethanol / pharmacology; Membranes, Artificial; Permeability / drug effects; Silicone Elastomers; Skin Absorption / drug effects; Skin Absorption / physiology; Solubility / drug effects; Solvents / pharmacology; Spectroscopy, Fourier Transform Infrared; Swine / physiology; Water / pharmacology; Xenobiotics / metabolism
TL;DR:
These studies suggest that stratum corneum partitioning of the compounds tested is primarily determined by relative compound solubility between the stratum Corneum lipids and the donor solvent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 conference paper
Continuing studies on the interaction of JP-8 and its constituent hydrocarbons with the skin
AFOSR Jet Fuel Toxicology Workshop. Presented at the AFOSR Jet Fuel Toxicology Workshop, Tucson, AZ.
Event: AFOSR Jet Fuel Toxicology Workshop at Tucson, AZ
Source: NC State University Libraries
Added: March 26, 2023
2004 article
Current approved drugs for aquatic species
Haskell, S. R. R., Payne, M. A., Webb, A. I., Riviere, J. E., & Craigmill, A. L. (2004, January 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 224, pp. 50–51.
MeSH headings : Animals; Aquaculture / methods; Aquaculture / standards; Drug Approval; Fish Diseases / drug therapy; Fishes; Legislation, Veterinary; United States; Veterinary Drugs / administration & dosage; Veterinary Drugs / adverse effects
TL;DR:
This Food Animal Residue Avoidance Databank Digest reviews drugs currently approved for use in aquatic species, chemicals that are not approved but are considered by the FDA' s Center for Veterinary Medicine (CVM) to be of low regulatory priority, and policies that can affect the use of these products.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Determination of the partition coefficients and absorption kinetic parameters of chemicals in a lipophilic membrane/water system by using a membrane-coated fiber technique
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 24(1), 15–23.
Contributors: X. Xia n, R. Baynes n , N. Monteiro-Riviere n & n
author keywords: absorption kinetics; membrane-coated fiber; diffusion coefficient; partition coefficient; boundary layer
MeSH headings : Absorption / drug effects; Absorption / physiology; Kinetics; Lipid Metabolism; Membranes, Artificial; Organic Chemicals / pharmacokinetics; Water / metabolism
TL;DR:
The kinetic model adequately described the absorption kinetics of the MCF technique and suggested that the absorption rate of a very lipophilic compound could be controlled by the boundary layer even though the diffusivity of the compound in the membrane is lower than that in the solution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 conference paper
Development of software that interfaces with the food animal residue avoidance databank to estimated withdrawal intervals for veterinary drugs
The Toxicologist, 78(S1), 206–207. https://www.toxicology.org/pubs/docs/Tox/2004Tox.pdf
Event: Society of Toxicology 43rd Annual Meeting at Baltimore, MD on March 21-25, 2004
Source: NC State University Libraries
Added: August 20, 2022
2004 conference paper
Differentiation of the absorption of kinetics of jet fuel hydrocarbons with an ethanol/water system and a membrane-coated fiber technique
The Toxicologist, 78(S1), 265. https://www.toxicology.org/pubs/docs/Tox/2004Tox.pdf
Event: Society of Toxicology 43rd Annual Meeting at Baltimore, MD on March 21-25, 2004
Source: NC State University Libraries
Added: August 20, 2022
2004 journal article
Dose related absorption of JP-8 jet fuel hydrocarbons through porcine skin with quantitative structure permeability relationship analysis
TOXICOLOGY MECHANISMS AND METHODS, 14(3), 159–166.
Contributors: F. Muhammad n, R. Baynes n , N. Monteiro-Riviere n , X. Xia n & n
author keywords: absorption; GC-SPME; hydrocarbons; jet fuels; porcine skin; QSPR
TL;DR:
The findings suggested a dose related increase in absorption for naphthalene and dimethyl naphthaene (DMN) in this solvent system by using their physicochemical parameters.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 article
Drugs approved for small ruminants
Webb, A. I., Baynes, R. E., Craigmill, A. L., Riviere, J. E., & Haskell, S. R. R. (2004, February 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 224, pp. 520–523.
MeSH headings : Animals; Camelids, New World; Deer; Dose-Response Relationship, Drug; Drug Administration Routes / veterinary; Drug Approval; Drug Residues; Goat Diseases / drug therapy; Goats; Legislation, Drug; Legislation, Veterinary; Ruminants; Sheep; Sheep Diseases / drug therapy; United States; United States Food and Drug Administration; Veterinary Drugs / therapeutic use
TL;DR:
Small ruminants are considered to include sheep, goats, deer, and camelids in the United States, and they are all considered minor species under the Food, Drug, and Cosmetics Act.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 journal article
Effect of vehicles and sodium lauryl sulphate on xenobiotic permeability and stratum corneum partitioning in porcine skin
TOXICOLOGY, 206(3), 325–335.
author keywords: skin permeability; dermal absorption; stratum corneum partitioning; water; ethanol; propylene glycol; phenol; p-nitrophenol; pentachlorophenol; methyl parathion; ethyl parathion; chlorpyrifos; fenthion; simazine; atrazine; propazine
MeSH headings : Agrochemicals / pharmacokinetics; Animals; Female; In Vitro Techniques; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Sodium Dodecyl Sulfate / pharmacology; Solvents / pharmacology; Swine; Xenobiotics / pharmacokinetics
TL;DR:
Addition of SLS to solvents altered partitioning and absorption characteristics across a range of compounds, which indicates that partition coefficients or skin permeability from neat chemical exposure should be used with caution in risk assessment procedures for chemical mixtures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Elimination kinetics of ceftiofur hydrochloride after intramammary administration in lactating dairy cows
Journal of the American Veterinary Medical Association, 224(11), 1827–1830.
MeSH headings : Animals; Anti-Infective Agents, Local / administration & dosage; Anti-Infective Agents, Local / analysis; Anti-Infective Agents, Local / pharmacokinetics; Cattle; Cephalosporins / administration & dosage; Cephalosporins / analysis; Cephalosporins / pharmacokinetics; Chromatography, High Pressure Liquid / veterinary; Drug Residues / analysis; Female; Lactation; Mammary Glands, Animal / metabolism; Mastitis, Bovine / drug therapy; Milk / chemistry; Prospective Studies; Reagent Kits, Diagnostic / veterinary
TL;DR:
Ceftiofur administered by the intramammary route as an extra-label treatment for mastitis in dairy cows reaches concentrations in milk greater than the tolerance set by the FDA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2004 journal article
Elimination kinetics of ceftiofur hydrochloride following intramammary administration in lactating dairy cattle
Le Medecin Veterinaire Du Quebec, 34, 115.
Source: NC State University Libraries
Added: March 26, 2023
2004 journal article
Feasibility of using half-life multipliers to estimate extended withdrawal intervals following the extralabel use of drugs in food-producing animals
JOURNAL OF FOOD PROTECTION, 67(3), 555–560.
MeSH headings : Algorithms; Animals; Animals, Domestic / metabolism; Drug Residues / analysis; Drug Residues / pharmacokinetics; Food Contamination / prevention & control; Half-Life; Legislation, Drug; Legislation, Veterinary; Meat / analysis; Models, Biological; Time Factors; United States; Veterinary Drugs / pharmacokinetics
TL;DR:
For the group of drugs investigated, a half-life multiplier of 5 resulted in estimates of extended withdrawal intervals that were potentially inadequate to prevent violative tissue residues for drugs that had relatively long tissue half- Lives, high tolerances, or both.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2004 conference paper
Influence of cutting fluid contaminants on the dermal disposition of the biocide, triazine
The Toxicologist, 78(S1), 326.
Event: Society of Toxicology 43rd Annual Meeting at Baltimore, MD on March 21-25, 2004
Source: NC State University Libraries
Added: September 23, 2022
2004 conference paper
Intracellular localization of multi-walled carbon nanotubes in human epidermal keratinocytes.
2nd Annual National Academies Keck Futures Initiative Conference. Presented at the 2nd Annual National Academies Keck Futures Initiative Conference: Irvine, CA.
Event: 2nd Annual National Academies Keck Futures Initiative Conference: at Irvine, CA on November 18-21, 2004
Source: NC State University Libraries
Added: November 23, 2022
2004 journal article
Meta-analysis of pharmacokinetic data of veterinary drugs using the Food Animal Residue Avoidance Databank: oxytetracycline and procaine penicillin G
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 27(5), 343–353.
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Anti-Bacterial Agents / pharmacology; Cattle / metabolism; Databases, Factual; Drug Residues / analysis; Injections, Intramuscular / veterinary; Oxytetracycline / administration & dosage; Oxytetracycline / blood; Oxytetracycline / pharmacokinetics; Oxytetracycline / pharmacology; Penicillin G Procaine / administration & dosage; Penicillin G Procaine / blood; Penicillin G Procaine / pharmacokinetics; Penicillin G Procaine / pharmacology; United States; United States Department of Agriculture
TL;DR:
A combination approach to meta-analysis of published mean data is recommended, where the TSM is the first step, followed by the NMEM approach, and all three methods generate comparable mean parameter estimates for OTC and PPG.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Multi-walled carbon nanotube interactions with human epidermal keratinocytes
TOXICOLOGY LETTERS, 155(3), 377–384.
Contributors: N. Monteiro-Riviere n , R. Nemanich n, A. Inman n, Y. Wang n & n
author keywords: multi-wall carbon nanotubes; human epidermal keratinocytes; transmission electron microscopy; IL-8
MeSH headings : Cell Nucleus / ultrastructure; Cell Survival; Cells, Cultured; Cytoplasm / ultrastructure; Humans; Interleukin-8 / biosynthesis; Keratinocytes / drug effects; Keratinocytes / immunology; Keratinocytes / ultrastructure; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanotubes, Carbon / analysis; Nanotubes, Carbon / chemistry; Nanotubes, Carbon / ultrastructure
TL;DR:
Data clearly show that MWCNT, not derivatized nor optimized for biological applications, are capable of both localizing within and initiating an irritation response in a target epithelial cell that composes a primary route of occupational exposure for manufactured nanotubes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2004 chapter
Percutaneous absorption of complex chemical mixtures
In Dermatotoxicology (6th ed.) (pp. 30–41). Boca Raton, FL: CRC Press.
Source: NC State University Libraries
Added: August 6, 2018
2004 report
Quantitating the Percutaneous Absorption of Mechanistically-Defined Chemical Mixtures
Source: Crossref
Added: December 24, 2021
2004 chapter
The isolated perfused porcine skin flap
In Dermatotoxicology (6th ed.) (pp. 564–588). Boca Raton, FL: CRC Press.
Source: NC State University Libraries
Added: August 6, 2018
2004 conference paper
Topical hydrocarbon absorption in porcine skin previously exposed to JP-8 jet fuel
The Toxicologist, 78(S1), 327. https://www.toxicology.org/pubs/docs/Tox/2004Tox.pdf
Event: Society of Toxicology 43rd Annual Meeting at Baltimore, MD on March 21-25, 2004
Source: NC State University Libraries
Added: August 20, 2022
2004 conference paper
Uptake kinetics of jet fuel aromatic hydrocarbons from aqueous solutions studied by a membrane-coated fiber technique
The Toxicologist, 78(S1), 265.
Event: Society of Toxicology 43rd Annual Meeting at Baltimore, MD on March 21-25, 2005
Source: NC State University Libraries
Added: September 23, 2022
2004 journal article
Veterinary application of in vitro dissolution data and the biopharmaceutics classification system
Pharmacopeial Forum, 30, 2295–2303.
Source: NC State University Libraries
Added: August 6, 2018
2003 conference paper
A mathematical model of permeation kinetics of the membrane-coated fiber technique accounting for partition, diffusion and boundary layer factors
The Toxicologist, 72(S1), 379.
Event: 42nd Annual Meeting & ToxExpo at Salt Lake City, UT on March 9-13, 2003
Source: NC State University Libraries
Added: September 23, 2022
2003 journal article
A novel in-vitro technique for studying percutaneous permeation with a membrane-coated fiber and gas chromatography/mass spectrometry: Part I. Performances of the technique and determination of the permeation rates and partition coefficients of chemical mixtures
PHARMACEUTICAL RESEARCH, 20(2), 275–282.
Contributors: X. Xia n, R. Baynes n , N. Monteiro-Riviere n , R. Leidy n, D. Shea n & n
author keywords: in-vitro; percutaneous absorption; membrane-coated fiber; chemical mixtures; partition coefficient
MeSH headings : Administration, Cutaneous; Gas Chromatography-Mass Spectrometry / instrumentation; Gas Chromatography-Mass Spectrometry / methods; Membranes, Artificial; Permeability; Pharmaceutical Preparations / analysis; Pharmaceutical Preparations / metabolism
TL;DR:
A novel in-vitro technique for rapid assessment of percutaneous absorption of chemical mixtures and the initial permeation rate and equilibrium time can be obtained for each compound, which could serve as characteristic parameters regarding the skin permeability of the compound.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 conference paper
Absorption through porcine skin exposed to various doses of jet fuel marker components determined with GC-FID using Head Space SPME fiber
The Toxicologist, 72(S1), 383. https://www.toxicology.org/pubs/docs/Tox/2003Tox.pdf
Event: 42nd Annual Meeting & ToxExpo at Salt Lake City, UT on March 9-13, 2003
Source: NC State University Libraries
Added: October 15, 2022
2003 book
Comparative Pharmacokinetics: Principles, Techniques and Applications
(p. 327). Ames, IA: Blackwell Publishing {Iowa State Press}.
Source: NC State University Libraries
Added: August 6, 2018
2003 journal article
Dermal disposition of triazine in cutting fluid mixtures
JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY, 22(4), 215–229.
author keywords: triazine; mixtures; dermal
TL;DR:
Assessment of 14C‐triazine membrane transport when topically applied to inert silastic membranes and porcine skin in an in vitro flow‐through diffusion cell system as aqueous mineral oil (MO) or aqueously polyethylene glycol (PEG) mixtures found triazine permeability was significantly enhanced by the complete mixture, especially in PEG‐based mixtures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 conference paper
Dermal disposition of triazine in cutting fluid mixtures
The Toxicologist, 72(S1), 381.
Event: 42nd Annual Meeting & ToxExpo at Salt Lake City, UT on March 9-13, 2003
Source: NC State University Libraries
Added: September 23, 2022
2003 conference paper
Dermal permeation of the sulfated fatty acid, recinoleic acid, is inhibited by complex mixture additives
The Toxicologist, 72(S1), 382–383. https://www.toxicology.org/pubs/docs/Tox/2003Tox.pdf
Event: 42nd Annual Meeting & ToxExpo at Salt Lake City, UT on March 9-13, 2003
Source: NC State University Libraries
Added: October 15, 2022
2003 journal article
Evaluation of the advisory services provided by the Food Animal Residue Avoidance Databank
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 223(11), 1596–1598.
MeSH headings : Animal Husbandry; Animals; Consumer Product Safety; Data Collection; Databases, Factual; Drug Approval; Drug Labeling; Drug Residues; Electronic Mail; Food Contamination / prevention & control; Humans; Information Systems; Telephone; United States; Veterinary Drugs / therapeutic use
TL;DR:
The Food Animal Residue Avoidance Databank (FARAD) offers expert-mediated advice on residue avoidance and mitigation for chemical contamination incidents and the extralabel use of drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2003 journal article
In vitro percutaneous absorption of nonylphenol (NP) and nonylphenol ethoxylates (NPE-4 and NPE-9) in isolated perfused skin
JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY, 22(1-2), 1–11.
Contributors: N. Monteiro-Riviere n , J. Van Miller, G. Simon, R. Joiner*, J. Brooks n & n
TL;DR:
The penetration of NPEs and NP in the IPPSF was less than the PSFT and is probably more predictive of in vivo human absorption as this model is physiologically closer to human skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 conference paper
JP-8 Interactions with the Skin: Absorption of Hydrocarbon Components, A Novel Membrane Coated Fiber (MCF) Technique for Fuel Component Clustering / QSAR Analysis, and the Effects of Inhibitors (Including Substance P) on Dermal Toxicity
AFOSR JP-8 Jet Fuel Toxicology Workshop. Presented at the AFOSR JP-8 Jet Fuel Toxicology Workshop, Tucson, AZ.
Event: AFOSR JP-8 Jet Fuel Toxicology Workshop at Tucson, AZ
Source: NC State University Libraries
Added: March 26, 2023
2003 journal article
JVPT 25 years on
Journal of Veterinary Pharmacology and Therapeutics, 26(1), 1–2.
Source: NC State University Libraries
Added: September 23, 2022
2003 journal article
Mechanisms of Skin Absorption
Journal of Veterinary Pharmacology and Therapeutics, 26(S1), 25–28.
Event: 9th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT) at Lisbon, Portugal on July 13-18, 2003
Source: NC State University Libraries
Added: August 6, 2018
2003 conference paper
Microbial risk assessment: Lessons learned from the National Academy of Sciences Committee on Scientific Criteria and Performance Standards for Safe Foods
Proceedings Society of Risk Analysis. Presented at the 2003 Annual Meeting, Society for Risk Analysis: "Bridging Risk Divides", Baltimore, MD.
Event: 2003 Annual Meeting, Society for Risk Analysis: "Bridging Risk Divides" at Baltimore, MD on December 7-10, 2003
Source: NC State University Libraries
Added: September 23, 2022
2003 journal article
Mixture additives inhibit the dermal permeation of the fatty acid, ricinoleic acid
Toxicology Letters, 147(1), 15–26.
author keywords: ricinoleic acid; skin; permeability; mixtures
MeSH headings : Alkanesulfonic Acids / chemistry; Alkanesulfonic Acids / pharmacokinetics; Animals; Dimethylpolysiloxanes; Drug Combinations; Ethanolamines / chemistry; Ethanolamines / pharmacokinetics; Female; Industrial Oils; Membranes, Artificial; Organ Culture Techniques; Permeability; Pharmaceutical Vehicles / chemistry; Pharmaceutical Vehicles / pharmacokinetics; Ricinoleic Acids / chemistry; Ricinoleic Acids / pharmacokinetics; Silicones; Skin / drug effects; Skin / metabolism; Skin Absorption; Swine; Triazines / chemistry; Triazines / pharmacokinetics; Tritium
TL;DR:
In silastic membranes and porcine skin, individual additives or combination of additives significantly reduced ricinoleic permeability, suggesting that the mixture interaction is more physicochemical in nature and probably not related to the chemical-induced changes in the biological membrane as may be assumed with topical exposures to potentially irritant formulations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2003 journal article
Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skin
TOXICOLOGY IN VITRO, 17(3), 289–292.
Contributors: A. Inman n, K. Still*, W. Jederberg*, R. Carpenter*, n, J. Brooks n, N. Monteiro-Riviere n
author keywords: 2,6-di-tert-butyl-4-nitrophenol; skin absorption; porcine skin; dermal exposure
MeSH headings : Absorption; Administration, Cutaneous; Air Pollution, Indoor; Animals; Antioxidants; Humans; Military Personnel; Nitrophenols / pharmacokinetics; Phenols / chemistry; Skin Physiological Phenomena; Static Electricity; Submarine Medicine; Swine
TL;DR:
DBNP absorption was minimal across all treatment groups, with the highest absorption detected being only 1.08% applied dose in an aqueous ethanol group, suggesting that there is minimal dermal exposure of DBNP when exposed topically to skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Percutaneous absorption of Topical N, N-Diethyl-M-Toluamide (DEET): Effects of exposure variables and coadministered toxicants
Journal of Toxicology and Environmental Health, Part A, 66(2), 133–151.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2003 conference paper
Population pharmacokinetics of marbofloxacin in Harbor Seals
American College of Veterinary Internal Medicine Proceedings. Presented at the 21st annual American College of Veterinary Internal Medicine Forum, Charlotte, NC.
Event: 21st annual American College of Veterinary Internal Medicine Forum at Charlotte, NC on June 4-8, 2003
Source: NC State University Libraries
Added: October 21, 2022
2003 conference paper
Predicting percutaneous permeation of chemicals using HiQSAR
AFOSR JP-8 Jet Fuel Toxicology Workshop. Presented at the AFOSR JP-8 Jet Fuel Toxicology Workshop, Tucson, AZ.
Event: AFOSR JP-8 Jet Fuel Toxicology Workshop at Tucson, AZ
Source: NC State University Libraries
Added: March 26, 2023
2003 journal article
Pyridostigmine bromide modulates topical irritant-induced cytokine release from human epidermal keratinocytes and isolated perfused porcine skin
TOXICOLOGY, 183(1-3), 15–28.
Contributors: N. Monteiro-Riviere n , R. Baynes n & n
author keywords: pyridostigmine bromide; skin; cytokines; permethrin; DEET; diisopropylfluorophosphate
MeSH headings : Administration, Cutaneous; Animals; Cells, Cultured; Cholinesterase Inhibitors / pharmacokinetics; Cholinesterase Inhibitors / toxicity; Cytokines / biosynthesis; Cytokines / metabolism; DEET / administration & dosage; DEET / pharmacokinetics; DEET / toxicity; Dinoprostone / biosynthesis; Drug Interactions; Female; Humans; In Vitro Techniques; Insect Repellents / administration & dosage; Insect Repellents / pharmacokinetics; Insect Repellents / toxicity; Insecticides / administration & dosage; Insecticides / pharmacokinetics; Insecticides / toxicity; Interleukin-8 / biosynthesis; Keratinocytes / drug effects; Keratinocytes / metabolism; Permethrin / administration & dosage; Permethrin / pharmacokinetics; Permethrin / toxicity; Persian Gulf Syndrome / chemically induced; Pyridostigmine Bromide / pharmacokinetics; Pyridostigmine Bromide / toxicity; Skin / drug effects; Skin / metabolism; Skin Absorption / drug effects; Skin Absorption / physiology; Swine; Tumor Necrosis Factor-alpha / biosynthesis
TL;DR:
It is suggested that systemic exposure to PB suppressed IL-8 release at multiple time points in two skin model systems, and effects on TNF-alpha and PGE(2) were vehicle dependent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 journal article
Skin toxicity of jet fuels: ultrastructural studies and the effects of substance P
TOXICOLOGY AND APPLIED PHARMACOLOGY, 195(3), 339–347.
Contributors: N. Monteiro-Riviere n , A. Inman n & n
author keywords: skin; Jet A; JP-8; JP-8+100; substance P; jet fuels
MeSH headings : Administration, Cutaneous; Animals; Cell Line; Humans; Hydrocarbons / toxicity; Interleukin-8 / immunology; Keratinocytes / drug effects; Keratinocytes / immunology; Keratinocytes / ultrastructure; Kerosene / toxicity; Microscopy, Electron; Mitochondrial Swelling / drug effects; Mitochondrial Swelling / immunology; Skin / drug effects; Skin / immunology; Skin / ultrastructure; Substance P / immunology; Substance P / pharmacology; Swine
TL;DR:
The primary change seen after exposure to all fuels was low-level inflammation accompanied by formation of lipid droplets in various skin layers, mitochondrial and nucleolar changes, cleft formation in the intercellular lipid lamellar bilayers, as well as disorganization in the stratum granulosum-stratum corneum interface.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2003 conference paper
The cytotooxicity of jet fuel aromatic hydrocarbons and dose-related interleukin-8 release from human epidermal keratinocytes
The Toxicologist, 72(S1), 383.
Event: 42nd Annual Meeting & ToxExpo at Salt Lake City, UT on March 9-13, 2003
Source: NC State University Libraries
Added: September 23, 2022
2003 journal article
The cytotoxicity of jet fuel aromatic hydrocarbons and dose-related interleukin-8 release from human epidermal keratinocytes
Archives of Toxicology, 77(7), 384–391.
Contributors: C. Chou n, n & N. Monteiro-Riviere n
author keywords: aromatic hydrocarbons; cytotoxicity; keratinocytes; interleukin-8; jet fuels
MeSH headings : Aircraft; Cells, Cultured; Epidermal Cells; Fuel Oils / toxicity; Humans; Hydrocarbons, Aromatic / toxicity; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Time Factors
TL;DR:
The presence of hexadecane and mineral oil greatly attenuated the cytotoxicity elicited by individual aromatic hydrocarbons in HEK cells and significantly increased with both doses of methylnaphthalene and naphthalenes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2003 journal article
Toxicokinetics and Physiologically Based Toxicokinetics in Toxicology and Risk Assessment
Journal of Toxicology and Environmental Health, Part B, 6(1), 1–40.
MeSH headings : Animals; Hazardous Substances / pharmacokinetics; Hazardous Substances / toxicity; Humans; Models, Chemical; Risk Assessment; Toxicology / methods; Xenobiotics / toxicity
TL;DR:
Physiologically based toxicokinetic (PB-TK) models are the kinetic models of the uptake and disposition of chemicals based on rates of biochemical reactions, physiological and anatomical characteristics that can predict target organ drug distribution in different species under variety of conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: December 24, 2021
2003 journal article
Update on FARAD food animal drug withholding recommendations
Journal of the American Veterinary Medical Association, 223(9), 1277–1278.
MeSH headings : Animal Husbandry / methods; Animals; Consumer Product Safety; Databases, Factual / statistics & numerical data; Drug Residues / analysis; Meat / analysis; Meat / standards; Veterinary Drugs / pharmacokinetics
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2002 conference paper
A novel technique to study percutaneous absorption by using a silastic membrane coated fiber
The Toxicologist, 66(S1), 164.
Event: 41st Annual Meeting & ToxExpo at Nashville, TN on March 17-21, 2002
Source: NC State University Libraries
Added: September 23, 2022
2002 journal article
Analysis of N,N-diethyl-m-toluamide in porcine skin perfusates using solid-phase extraction disks and reversed-phase high-performance liquid chromatography
Journal of Chromatography B, 780(1), 45–52.
author keywords: N,N-Diethyl-m-toluamide
MeSH headings : Animals; Chromatography, High Pressure Liquid / methods; DEET / analysis; Insect Repellents / analysis; Permeability; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Skin / chemistry; Swine
TL;DR:
An improved method was developed for determining transdermal diffusion of low levels of DEET following application to an in vitro porcine skin flow-through diffusion cell system and it was determined that DEET permeability in porcines skin was 2.55 x 10(-5)+/-0.54 x 10-5 cm/h.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2002 review
Applying the biopharmaceutics classification system to veterinary pharmaceutical products Part II. Physiological considerations
[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 54(6), 825–850.
author keywords: biopharmaceutics classification system; interspecies differences; veterinary oral drug absorption; animal models; food effects; lymphatic uptake
MeSH headings : Animal Feed; Animals; Biological Availability; Digestive System Physiological Phenomena; Food-Drug Interactions; Gastrointestinal Transit; Humans; Intestinal Absorption; Solubility; Species Specificity; Veterinary Drugs / administration & dosage; Veterinary Drugs / chemistry; Veterinary Drugs / pharmacokinetics
TL;DR:
This work considers the likely physiological causes for species-related differences in the absolute and relative bioavailability of orally administered pharmaceuticals, and examines the potential for these normal interspecies differences to reflect bioavailability changes that can occur with various human pathologies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 book
Chemical Food Safety: a scientist's perspective.
Ames, Iowa: Iowa State Press.
Source: NC State University Libraries
Added: October 15, 2022
2002 book
Chemical food safety: A scientist's perspective
Ames, Iowa: Iowa State Press.
Source: NC State University Libraries
Added: August 6, 2018
2002 conference paper
Cutting fluid formulations influence the dermal disposition of linear alkylbenzene sulfonate (LAS
The Toxicologist, 66(S1), 164.
Event: 41st Annual Meeting & ToxExpo at Nashville, TN on March 17-21, 2002
Source: NC State University Libraries
Added: September 23, 2022
2002 conference paper
Dermal absorption and toxicity of jet fuel and its components
AFOSR JP-8 Jet Fuel Toxicology Workshop. Presented at the AFOSR JP-8 Jet Fuel Toxicology Workshop, Tucson, AZ.
Event: AFOSR JP-8 Jet Fuel Toxicology Workshop at Tucson, AZ
Source: NC State University Libraries
Added: March 26, 2023
2002 journal article
Differential relationship between the carbon chain length of jet fuel aliphatic hydrocarbons and their ability to induce cytotoxicity vs. interleukin-8 release in human epidermal keratinocytes
TOXICOLOGICAL SCIENCES, 69(1), 226–233.
Contributors: C. Chou n, & N. Monteiro-Riviere
author keywords: keratinocytes; aliphatic hydrocarbons; cytotoxicity; interleukin-8; jet fuels
MeSH headings : Aviation; Cell Survival / drug effects; Cells, Cultured; Epidermal Cells; Fuel Oils / toxicity; Humans; Hydrocarbons / toxicity; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Structure-Activity Relationship
TL;DR:
Individual aliphatic hydrocarbons are toxic to HEK cells and are capable of inducing proinflammatory cytokines, indicating a different structure-activity relationship for these two toxicological endpoints in keratinocyte cell cultures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2002 journal article
Effect of chemical interactions in pentachlorophenol mixtures on skin and membrane transport
TOXICOLOGICAL SCIENCES, 69(2), 295–305.
author keywords: pentachorophenol; mixtures; interactions; skin; absorption; surfactants; vehicle
MeSH headings : Animals; Chemical Phenomena; Chemistry, Physical; Diffusion; Ethanol / pharmacology; In Vitro Techniques; Insecticides / chemistry; Insecticides / pharmacokinetics; Insecticides / toxicity; Membranes / metabolism; Nicotinic Acids / pharmacology; Pentachlorophenol / chemistry; Pentachlorophenol / pharmacokinetics; Pentachlorophenol / toxicity; Permeability / drug effects; Pharmaceutical Vehicles; Skin Absorption / drug effects; Sodium Dodecyl Sulfate / pharmacology; Solvents / pharmacology; Viscosity
TL;DR:
It is demonstrated that modification in mixture composition with either a solvent and/or a surfactant can influence PCP diffusion in skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
Extrapolated withdrawal-interval estimator (EWE) algorithm: A quantitative approach to establishing extralabel withdrawal times
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 36(1), 131–137.
author keywords: extralabel; withdrawal interval; Extrapolated Withdrawal-Interval Estimator Algorithm; residues; population pharmacokinetics
MeSH headings : Algorithms; Animals; Animals, Domestic / metabolism; Drug Residues / pharmacokinetics; Half-Life; Legislation, Drug; Legislation, Veterinary; Models, Biological; Time Factors; United States; Veterinary Drugs / administration & dosage; Veterinary Drugs / pharmacokinetics
TL;DR:
The present study introduces and validates with simulated and experimental data the Extrapolated Withdrawal-Period Estimator (EWE) Algorithm, a procedure aimed at predicting extralabel withdrawal intervals (WDIs) based on the label and pharmacokinetic literature data contained in the Food Animal Residue Avoidance Databank (FARAD).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
Gulf War related exposure factors influencing topical absorption of 14C-permethrin
Toxicology Letters, 135(1-2), 61–71.
Contributors: n, N. Monteiro-Riviere n & R. Baynes n
author keywords: permethrin; Gulf War; JP-8; jet fuel; sulfur mustard; skin; absorption
MeSH headings : Animals; Cholinesterase Inhibitors; DEET / toxicity; Dermatologic Agents / pharmacology; Dermatologic Agents / toxicity; Environmental Exposure / adverse effects; Humans; Hydrocarbons / toxicity; In Vitro Techniques; Insect Repellents / toxicity; Insecticides / pharmacokinetics; Insecticides / toxicity; Isoflurophate / toxicity; Mustard Gas / toxicity; Permethrin / pharmacokinetics; Permethrin / toxicity; Persian Gulf Syndrome / chemically induced; Skin / drug effects; Skin / metabolism; Skin Absorption / physiology; Swine
TL;DR:
It is suggested that co-exposure to JP-8 or sulfur mustard may modulate transdermal flux of 14C-permethrin and this moderate increase in permethrin absorption remains unclear.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2002 conference paper
Lack of effects of sulfur mustard and JP-8 jet fuel on percutaneous absorption of simultaneously administered topical permethrin and DEET
Toxicological Sciences, 66(S1), 162–163.
Event: 41st Annual Meeting & ToxExpo at Nashville, TN on March 17-21, 2002
Source: NC State University Libraries
Added: September 23, 2022
2002 journal article
Mixed-effects modeling of the interspecies pharmacokinetic scaling of oxytetracycline
JOURNAL OF PHARMACEUTICAL SCIENCES, 91(2), 331–341.
author keywords: NONMEM; oxytetracycline; allometry; population pharmacokinetics
MeSH headings : Animals; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Cattle; Goats; Horses; Models, Biological; Oxytetracycline / blood; Oxytetracycline / pharmacokinetics; Rabbits; Sheep; Species Specificity; Swine
TL;DR:
Allometric scaling models for oxytetracycline were developed, using serum disposition data obtained from the Food Animal Residue Avoidance Databank, and the best interspecies model adequately predicted the value of the pharmacokinetic parameters across species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 conference paper
On clustering of JP-8 chemicals
Joint Meeting of the Society of Environmental Toxicology and Chemistry and Society of Toxicology. Presented at the Joint Meeting of the Society of Environmental Toxicology and Chemistry and Society of Toxicology, Duluth, MN.
Event: Joint Meeting of the Society of Environmental Toxicology and Chemistry and Society of Toxicology at Duluth, MN
Source: NC State University Libraries
Added: March 26, 2023
2002 report
Percutaneous absorption of chemical mixtures relevant to the Gulf War
In Annual Report to Congress on Gulf War Illnesses. Appendix. (Report No. DAMD17-99-C-9047; pp. 169–170). https://apps.dtic.mil/sti/pdfs/ADA409100.pdf
Source: NC State University Libraries
Added: October 21, 2022
2002 report
Percutaneous absorption of chemical mixtures relevant to the Gulf War.
(Technical Report No. DAMD17-99-C-9047). https://apps.dtic.mil/sti/pdfs/ADA409100.pdf
Source: NC State University Libraries
Added: October 21, 2022
2002 journal article
Physicochemical determinants of linear alkylbenzene sulfonate (LAS) disposition in skin exposed to aqueous cutting fluid mixtures
TOXICOLOGY AND INDUSTRIAL HEALTH, 18(5), 237–248.
author keywords: cutting fluids; LAS; mixtures; physicochemical interactions; skin
MeSH headings : Alkanesulfonic Acids / chemistry; Alkanesulfonic Acids / pharmacokinetics; Alkanesulfonic Acids / toxicity; Animals; Dermatitis, Contact / etiology; Metallurgy; Mineral Oil / pharmacology; Occupational Exposure; Permeability; Polyethylene Glycols / pharmacology; Skin Absorption / drug effects; Solubility; Solvents / pharmacology; Surface-Active Agents / chemistry; Surface-Active Agents / pharmacokinetics; Surface-Active Agents / toxicity; Swine
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
Pyridostigmine bromide modulates the dermal disposition of [C-14]permethrin
TOXICOLOGY AND APPLIED PHARMACOLOGY, 181(3), 164–173.
Contributors: R. Baynes n , N. Monteiro-Riviere n & n
author keywords: permethrin; pyridostigmine bromide; skin; absorption
MeSH headings : Animals; Biological Availability; Chemical Phenomena; Chemistry, Physical; Cholinesterase Inhibitors / pharmacology; Diffusion; Drug Interactions; Female; In Vitro Techniques; Insecticides / pharmacokinetics; Isoflurophate / pharmacology; Permethrin / pharmacokinetics; Persian Gulf Syndrome; Pharmaceutical Vehicles; Pyridostigmine Bromide / pharmacology; Skin Absorption / drug effects; Swine
TL;DR:
It is suggested that intraarterial perfusion of PB and/or DFP and topical application of DFP or DEET can alter the disposition of [14C]permethrin in skin and possibly its bioavailability in soldiers simultaneously exposed to these chemicals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2002 conference paper
Pyridostigmine bromide suppresses IL-8 in human epidermal keratinocytes and in isolated perfused porcine skin exposed to DEET and permethrin
The Toxicologist, 66(S1), 162. https://www.toxicology.org/pubs/docs/Tox/2002Tox.pdf
Event: 41st Annual Meeting & ToxExpo at Nashville, TN on March 17-21, 2002
Source: NC State University Libraries
Added: October 15, 2022
2002 journal article
Systemic uptake and cutaneous disposition of pentachlorophenol in a sequential exposure scenario: Effects of skin preexposure to benzo[a] pyrene
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A, 65(18), 1307–1331.
MeSH headings : Adipose Tissue; Administration, Cutaneous; Animals; Benzo(a)pyrene / pharmacology; Biotransformation; Carcinogens / pharmacology; Drug Interactions; Environmental Exposure; Environmental Pollutants / metabolism; Environmental Pollutants / pharmacokinetics; Pentachlorophenol / metabolism; Pentachlorophenol / pharmacokinetics; Risk Assessment; Skin; Swine; Tissue Distribution
TL;DR:
Skin preexposure to BaP may considerably modify cutaneous biotransformation rate and thus deserves further investigation, suggesting the prolonged observation period may conceal existing impact of potentially modified disposition processes, such as cutaneous metabolism, on systemic absorption.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
The use of enzyme histochemistry in detecting cutaneous toxicity of three topically applied jet fuel mixtures
Toxicology Mechanisms and Methods, 12(1), 17–34.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2002 journal article
Toxicokinetics and physiologically based toxicokinetics in toxicology and risk assessment
Journal of Toxicology and Environmental Health. Part B, Critical Reviews, 6(1), 1–40.
Source: NC State University Libraries
Added: August 6, 2018
2001 chapter
Aminoglycoside Antibiotics
In H. R. Adams (Ed.), Veterinary Pharmacology and Therapeutics (8th ed., pp. 841–867). Ames, Iowa: Iowa State University Press.
Ed(s): H. Adams
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Analysis of interleukin-8 release from normal human epidermal keratinocytes exposed to aliphatic hydrocarbons: delivery of hydrocarbons to cell cultures via complexation with alpha-cyclodextrin
TOXICOLOGY IN VITRO, 15(6), 663–669.
Contributors: D. Allen n, n & N. Monteiro-Riviere n
author keywords: keratinocyte; cytokine; jet fuel; hydrocarbon; cyclodextrin
MeSH headings : Cells, Cultured; Cyclodextrins / chemistry; Dose-Response Relationship, Drug; Drug Carriers / chemistry; Humans; Hydrocarbons / chemistry; Hydrocarbons / toxicity; Interleukin-8 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / ultrastructure; Kerosene / toxicity; Solubility; alpha-Cyclodextrins
TL;DR:
These studies demonstrate that the etiology of proinflammatory cytokine expression due to jet fuel exposure may be due in large part to the aliphatic hydrocarbon components and provide additional evidence that hydrocarbons can be successfully delivered to cells in culture by encapsulating them in cyclodextrin inclusion complexes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 conference paper
Analysis of pro-inflammatory cytokines produced in primary and immortalized porcine keratinocytes exposed to jet fuels: A comparison to normal human epidermal keratinocytes
[Abstract]. Toxicological Sciences, 60(S1), 179. https://www.toxicology.org/pubs/docs/Tox/2001Tox.pdf
Event: 40th Annual Meeting, Society of Toxicology at San Francisco, CA on February 25, 2001
Source: NC State University Libraries
Added: August 20, 2022
2001 chapter
Antifungal and antiviral drugs
In Veterinary Pharmacology: Therapeutics (8th ed.) (pp. 918–946). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
2001 chapter
Antiseptics/disinfectants
In Veterinary Pharmacology: Therapeutics (8th ed.) (pp. 783–795). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
2001 chapter
Chemical residues in tissues of food animals
In Veterinary pharmacology and therapeutics (8th ed.) (pp. 1166–1174). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
2001 chapter
Chloramphenicol and derivatives, macrolides, lincosamides, and miscellaneous antibiotics
In Veterinary pharmacology and therapeutics (8th ed.) (pp. 868–897). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Cytokine induction as a measure of cutaneous toxicity in primary and immortalized porcine keratinocytes exposed to jet fuels, and their relationship to normal human epidermal keratinocytes
TOXICOLOGY LETTERS, 119(3), 209–217.
Contributors: D. Allen n, n & N. Monteiro-Riviere n
author keywords: immortalized keratinocyte; cytokine; jet fuel; toxicity
MeSH headings : Analysis of Variance; Animals; Biomarkers; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Female; Fuel Oils / toxicity; Humans; Interleukin-8 / biosynthesis; Keratinocytes / drug effects; Keratinocytes / metabolism; RNA, Messenger / isolation & purification; Swine; Tumor Necrosis Factor-alpha / biosynthesis
TL;DR:
The results suggest that porcine keratinocytes are susceptible to jet fuel toxicity, however, the responses of immortalized cells may vary from those of PKC and NHEK necessitating cautious interpretation of such data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2001 conference paper
DEET and pyridostigmine bromide effects on dermal disposition of permethrin
Proceedings of the Conference on Illness among Gulf War Veterans: A Decade of Scientific Research, 152.
Event: Conference on Illness among Gulf War Veterans: A Decade of Scientific Research at Alexandra, VA
Source: NC State University Libraries
Added: October 21, 2022
2001 conference paper
Dermal absorption and toxicity of topically applied jet fuels: In vitro and in vivo studies
AFOSR JP-8 Jet Fuel Toxicology Workshop. Presented at the AFOSR JP-8 Jet Fuel Toxicology Workshop, Tucson, AZ.
Event: AFOSR JP-8 Jet Fuel Toxicology Workshop at Tucson, AZ
Source: NC State University Libraries
Added: March 26, 2023
2001 report
Dermal absorption cutting fluids
In Annual report 1R010H03669-01A2.
Source: NC State University Libraries
Added: August 6, 2018
2001 conference paper
Dermal exposure assessment and comparative penetration studies of pentachlorophenol using in vitro human skin, tissue culture, and porcine skin models
American Industrial Hygiene Conference and Exposition. Presented at the American Industrial Hygiene Conference and Exposition, New Orleans, LA.
Event: American Industrial Hygiene Conference and Exposition at New Orleans, LA on June 2-7, 2001
Source: NC State University Libraries
Added: October 21, 2022
2001 chapter
Dermatopharmacology: drugs acting locally on the skin
In Veterinary pharmacology and therapeutics (8th ed.) (Vol. 53, pp. 1084–1104). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Effect of selective lipid extraction from different body regions on epidermal barrier function
PHARMACEUTICAL RESEARCH, 18(7), 992–998.
author keywords: epidermal lipids; ceramides; lipid extraction; tape stripping; transepidermal water loss (TEWL); electron microscopy; membrane lipids
MeSH headings : Abdomen; Animals; Back; Epidermis / drug effects; Epidermis / metabolism; Epidermis / physiology; Epidermis / ultrastructure; Erythema / chemically induced; Erythema / metabolism; Erythema / pathology; Female; Groin; Lipid Metabolism; Skin Absorption / drug effects; Skin Irritancy Tests / methods; Solvents / administration & dosage; Swine; Water / metabolism
TL;DR:
It is suggested that strategies that could biochemically alter epidermal lipid composition may increase absorption of simultaneously administered topical compounds and may be useful to enhance drug delivery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Effects of short-term high-dose and low-dose dermal exposure to Jet A, JP-8 and JP-8 + 100 jet fuels
Journal of Applied Toxicology, 21(6), 485–494.
Contributors: N. Monteiro-Riviere n , A. Inman n & n
author keywords: skin; jet fuels; Jet A; JP-8; JP-8+100; dermatopathology; dermatotoxicity; pig; hydrocarbon fuels
MeSH headings : Administration, Cutaneous; Aircraft; Animals; Cell Division / drug effects; Clothing; Edema / chemically induced; Edema / pathology; Epidermis / drug effects; Epidermis / pathology; Erythema / chemically induced; Erythema / pathology; Female; Humans; Hydrocarbons / administration & dosage; Hydrocarbons / toxicity; Kerosene / toxicity; Occupational Exposure; Swine; Water-Electrolyte Balance
TL;DR:
It is found that the high‐dose fabric‐soaked exposure at 5 days to Jet A, JP‐8 andJP‐8 + 100 fuels caused the greatest increase in cutaneous erythema, edema, epidermal thickness and rete peg depth compared with high‐ dose non‐occluded or low‐dose exposure under Hill Top occluded and non-occluded conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2001 journal article
Enhanced Systemic Tissue Distribution after Dermal versus Intravenous 3,3′,4,4′-Tetrachlorobiphenyl Exposure: Limited Utility of Radiolabel Blood Area under the Curve and Excretion Data in Dermal Absorption Calculations and Tissue Exposure Assessment
Toxicology and Applied Pharmacology, 177(1), 26–37.
MeSH headings : Administration, Cutaneous; Animals; Area Under Curve; Body Burden; Carbon Radioisotopes; Environmental Exposure; Female; Injections, Intravenous; Polychlorinated Biphenyls / administration & dosage; Polychlorinated Biphenyls / pharmacokinetics; Swine; Tissue Distribution
TL;DR:
A long-term, low-input exposure pattern similar to this 3,3',4,4'-tetrachlorobiphenyl exposure could be more harmful to systemic tissues than a short- term, high-dose exposureSimilar to this iv exposure and some conventional approaches using label determination in blood and excreta without full mass balance studies may underestimate dermal absorption of chemicals similar to TCB.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2001 chapter
Fluoroquinolones antimicrobial drugs
In Veterinary pharmacology and therapeutics (8th ed.) (Vol. 45, pp. 898–917). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
2001 conference paper
In vitro percutaneous absorption of nonylphenol (NP) and nonylphenol ethoxylates NPE-4 and NPE-9 in isolated perfused skin
Toxicological Sciences, 60(S1), 60. https://www.toxicology.org/pubs/docs/Tox/2001Tox.pdf
Event: 40th Annual Meeting, Society of Toxicology at San Francisco, CA on March 25-29, 2001
Source: NC State University Libraries
Added: August 20, 2022
2001 conference paper
Influence of DEET and pyridostigmine bromide on dermal disposition of permethrin
[Abstract]. The Toxicologist, 60(S1), 128–129, https://www.toxicology.org/pubs/docs/Tox/2001Tox.pdf
Event: 40th Annual Meeting, Society of Toxicology at San Francisco, CA on February 25, 2001
Source: NC State University Libraries
Added: September 23, 2022
2001 conference paper
JP-8 additives can influence the dermal absorption of jet fuel components
Toxicological Sciences, 60(S1), 57–58. https://www.toxicology.org/pubs/docs/Tox/2001Tox.pdf
Event: 40th Annual Meeting, Society of Toxicology at San Francisco, CA on March 25-29, 2001
Source: NC State University Libraries
Added: August 20, 2022
2001 journal article
Mixed effects modeling of the disposition of gentamicin across domestic animal species
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 24(5), 321–332.
MeSH headings : Animals; Anti-Bacterial Agents / pharmacokinetics; Cats; Databases, Factual; Dogs; Gentamicins / pharmacokinetics; Goats; Half-Life; Horses; Metabolic Clearance Rate; Models, Biological; Rabbits; Sheep; Species Specificity; Swine
TL;DR:
The pharmacokinetic characteristics of drugs such as gentamicin, can be predicted across species using a population pharmacokinetics modeling approach, and that clinical features that affect species in a similar manner can be also explored in this fashion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Mixture component effects on the in vitro dermal absorption of pentachlorophenol
Archives of Toxicology, 75(6), 329–334.
MeSH headings : Administration, Topical; Animals; Culture Techniques; Dermis / blood supply; Dermis / metabolism; Dose-Response Relationship, Drug; Environmental Pollutants / administration & dosage; Environmental Pollutants / pharmacokinetics; Ethanol / pharmacology; Irritants / pharmacology; Nicotinic Acids / pharmacology; Pentachlorophenol / administration & dosage; Pentachlorophenol / pharmacokinetics; Perfusion; Polychlorinated Biphenyls / administration & dosage; Polychlorinated Biphenyls / pharmacokinetics; Risk Assessment; Skin Absorption; Sodium Dodecyl Sulfate / pharmacology; Surface-Active Agents / pharmacology; Swine
TL;DR:
The results suggest that dermal absorption estimates from a single chemical exposure may not reflect absorption seen after exposure as a chemical mixture and that absorption of both TCB and PCB are minimal in this model system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2001 journal article
Mixture effects of JP-8 additives on the dermal disposition of jet fuel components
TOXICOLOGY AND APPLIED PHARMACOLOGY, 175(3), 269–281.
author keywords: jet fuels; mixtures; skin; interactions; absorption
MeSH headings : Alkanes / pharmacokinetics; Animals; Drug Synergism; Hydrocarbons / chemistry; Hydrocarbons / pharmacokinetics; In Vitro Techniques; Kerosene; Naphthalenes / pharmacokinetics; Perfusion; Skin / drug effects; Skin / metabolism; Skin Absorption; Swine; Tissue Distribution
TL;DR:
The data suggest that various combinations of these three performance additives in JP-8 can potentially alter the dermal disposition of aromatic and aliphatic fuel components in skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2001 conference paper
Modeling percutaneous absorption from complex chemical mixtures
The Toxicologist, 60(S1), 60.
Event: 40th Annual Meeting, Society of Toxicology on March 25-29, 2001
Source: NC State University Libraries
Added: September 23, 2022
2001 conference paper
Morphological assessment of short term dermal application of Jet-A, JP-8, and JP-8+100 in the pig
Toxicological Sciences, 60(S1), 57. https://www.toxicology.org/pubs/docs/Tox/2001Tox.pdf
Event: 40th Annual Meeting, Society of Toxicology at San Francisco, CA
Source: NC State University Libraries
Added: August 20, 2022
2001 chapter
Penicillins and Related -Lactam Antibiotics
In H. R. Adams (Ed.), Veterinary Pharmacology and Therapeutics (8th ed., pp. 818–827). Ames, Iowa: Iowa State University Press.
Ed(s): H. Adams
Source: NC State University Libraries
Added: August 20, 2022
2001 chapter
Penicillins and related beta-Lactam antibiotics
In Veterinary pharmacology and therapeutics (8th ed.) (pp. 818–827). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
2001 chapter
Pesticide disposition: dermal absorption
In Handbook of Pesticide Toxicology (2nd ed.) (pp. 515–530).
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2001 review
Potential and problems of developing transdermal patches for veterinary applications
[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 50(3), 175–203.
author keywords: veterinary drug delivery; transdermal drug delivery; fentanyl; iontophoresis
MeSH headings : Administration, Cutaneous; Animal Diseases / drug therapy; Animals; Diffusion; Drug Delivery Systems; Fentanyl / pharmacokinetics; Humans; Iontophoresis; Pesticides / pharmacokinetics; Skin / anatomy & histology; Skin / metabolism; Skin Absorption
TL;DR:
The human transdermal fentanyl patch has been successfully used in cats and dogs for post-operative analgesia and a number of insecticides have been developed in liquid "pour-on" formulations that illustrate the efficacy of this route of administration for veterinary species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2001 report
Quantitating the percutaneous absorption of mechanistically-defined chemical mixtures.
(Final Report No. AFOSR GF 49620-98-1-0105; pp. 1–109). https://apps.dtic.mil/sti/pdfs/ADA422081.pdf
Source: NC State University Libraries
Added: October 21, 2022
2001 conference paper
Significant effects of application vehicle, skin occlusion, cutaneous CYP450 induction, and ambient temperature on dermal absorption and cutaneous disposition of pentachlorophenol (PCP
Toxicological Sciences, 60(S1), 60. https://www.toxicology.org/pubs/docs/Tox/2001Tox.pdf
Event: 40th Annual Meeting, Society of Toxicology at San Francisco, CA on March 25-29, 2001
Source: NC State University Libraries
Added: August 20, 2022
2001 conference paper
Stereochemistry of dermal absorption of permethrin
Proceedings of Illness Among Gulf War Veterans: A Decade of Scientific Research. Presented at the Illness Among Gulf War Veterans: A Decade of Scientific Research, Alexandra, VA.
Event: Illness Among Gulf War Veterans: A Decade of Scientific Research at Alexandra, VA on January 24-26, 2001
Source: NC State University Libraries
Added: November 23, 2022
2001 conference paper
Stereoselective absorption of permethrin through silastic membrane and excised porcine skin in vitro flow through diffusion system
The Toxicologist, 60(1S), 129.
Event: 40th Annual Meeting, Society of Toxicology at San Francisco, CA on March 25-29, 2001
Source: NC State University Libraries
Added: September 23, 2022
2001 chapter
Sulfonamides
In H. R. Adams (Ed.), Veterinary Pharmacology and Therapeutics (8th ed., pp. 796–817). Ames, Iowa: Iowa State University Press.
Ed(s): H. Adams
Source: NC State University Libraries
Added: August 6, 2018
2001 conference paper
Systemic pyridostiogmine suppresses inflamatory cytokine release after topical permethrin and DEET exposure
Proceedings of the Conference on Illness among Gulf War Veterans: A Decade of Scientific Research, 149.
Event: Conference on Illness among Gulf War Veterans: A Decade of Scientific Research at Alexandra, VA
Source: NC State University Libraries
Added: October 21, 2022
2001 chapter
Tetracyclines
In H. R. Adams (Ed.), Veterinary Pharmacology and Therapeutics (8th ed., pp. 828–840). Ames, Iowa: Iowa State University Press.
Ed(s): H. Adams
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Use of methyl salicylate as a simulant to predict the percutaneous absorption of sulfur mustard
JOURNAL OF APPLIED TOXICOLOGY, 21(2), 91–99.
Contributors: n, C. Smith n, K. Budsaba n, J. Brooks n, E. Olajos*, H. Salem*, N. Monteiro-Riviere n
MeSH headings : Administration, Cutaneous; Adsorption; Animals; Area Under Curve; Carbon Radioisotopes; Culture Techniques; Dermatologic Agents / pharmacokinetics; Fixatives; Models, Biological; Mustard Gas / pharmacokinetics; Salicylates / pharmacokinetics; Skin / drug effects; Skin / pathology; Swine
TL;DR:
Compared with other chemicals studied in this model, HD and MS cutaneous disposition were very similar, supporting the use of MS as a dermal simulant for HD exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2000 journal article
Amoxicillin pharmacokinetics in harbor seals (Phoca vitulina) and northern elephant seals (Mirounga angustirostris) following single dose intravenous administration: implications for interspecific dose sealing
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 23(4), 223–228.
MeSH headings : Amoxicillin / administration & dosage; Amoxicillin / blood; Amoxicillin / pharmacokinetics; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Dose-Response Relationship, Drug; Injections, Intravenous / veterinary; Seals, Earless / classification; Seals, Earless / metabolism
TL;DR:
A true physiologic difference in drug handling, possibly related to renal perfusion or tubal secretory efficiency could affect amoxicillin kinetics in these species, and longer administration intervals may be appropriate for elephant seals as compared to harbor seals when administering multiple dose amoxicalin therapy at 20 mg/kg.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 conference paper
Application of a human skin tissue culture model in dermal absorption studies of 3,3’,4,4’-tetrachlorobiphenyl (TCB)
Toxicological Sciences, 54(S1), 150. https://www.toxicology.org/pubs/docs/Tox/2000Tox.pdf
Event: 39th Annual Meeting of the Society of Toxicology at Philadelphia, PA on March 19-23, 2000
Source: NC State University Libraries
Added: August 20, 2022
2000 conference paper
Basic toxicokinetic principles and methodology
Toxicokinetics and Physiologically-Based Toxicokinetics in Toxicology and Risk Assessment: Continuing Education Course Syllabus, 39th Annual Meeting of the Society of Toxicology, 39, 2–18.
Source: NC State University Libraries
Added: August 6, 2018
2000 conference paper
Clustering of JP-8 chemicals using property spaces and structural spaces: A novel tool for hazard assessment
Proceedings of the 2nd Indo-US Workshop on Mathematical Chemistry, 44.
Event: 2nd Indo-US Workshop on Mathematical Chemistry
Source: NC State University Libraries
Added: March 26, 2023
2000 conference paper
Clustering of JP-8 chemicals using structure spaces and property spaces. A computational approach
AFOSR JP-8 Jet Fuel Toxicology Workshop. Presented at the AFOSR JP-8 Jet Fuel Toxicology Workshop, Tucson, AZ.
Event: AFOSR JP-8 Jet Fuel Toxicology Workshop at Tucson, AZ
Source: NC State University Libraries
Added: March 26, 2023
2000 journal article
Comparative in vitro percutaneous absorption of nonylphenol and nonylphenol ethoxylates (NPE-4 and NPE-9) through human, porcine and rat skin
Toxicology and Industrial Health, 16(2), 49–57.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018
2000 conference paper
Comparative in vitro percutaneous absorption of nonylphenol and nonylphenol ethoxylates (NPE-4 and NPE-9) through human, porcine and rat skin
The Toxicologist, 54(S1), 149–150.
Event: 39th Annual Meeting of the Society of Toxicology at Philadelphia, PA on March 19-23, 2000
Source: NC State University Libraries
Added: September 23, 2022
2000 journal article
Compass plots: A combination of star plot and analysis of means to visualize significant interactions in complex toxicology studies
TOXICOLOGY METHODS, 10(4), 313–332.
author keywords: analysis of means; Bonferroni method; chemical mixtures; 2(p) factorial experiments; Kimball inequality; parathion; star plot; Yates algorithm
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 conference paper
Cutaneous enzyme histochemistry of topically applied jet fuels in the pig
The Toxicologist, 54(S1), 151.
Event: 39th Annual Meeting of the Society of Toxicology at Philadelphia, PA on March 19-23, 2000
Source: NC State University Libraries
Added: September 23, 2022
2000 conference paper
Cutaneous irritation of topically applied jet fuels in the pig
The Toxicologist, 54(S1), 151.
Event: 39th Annual Meeting of the Society of Toxicology at Philadelphia, PA on March 19-23, 2000
Source: NC State University Libraries
Added: September 23, 2022
2000 conference paper
Cytokine release from keratinocytes exposed to Jet A, JP8, JP8-100 jet fuels
The Toxicologist, 54(S1), 151.
Event: 39th Annual Meeting of the Society of Toxicology at Philadelphia, PA on March 19-23, 2000
Source: NC State University Libraries
Added: September 23, 2022
2000 journal article
Dermal absorption and tissue disposition of 3,3',4,4'-tetrachlorobiphenyl (TCB) in an ex vivo pig model: Assessing the impact of dermal exposure variables
International Journal of Occupational and Environmental Health, 6, 127–137.
MeSH headings : Animals; Female; Linear Models; Pharmaceutical Vehicles; Pharmacokinetics; Polychlorinated Biphenyls / metabolism; Skin / drug effects; Skin Absorption; Soil Pollutants / metabolism; Swine
TL;DR:
Dermal absorption data from liquid-organic or aqueousorganic mixtures may underestimate the risk of exposure to TCB-contaminated soil.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Dermatotoxicokinetic modeling of p-nitrophenol and its conjugation metabolite in swine following topical and intravenous administration
TOXICOLOGICAL SCIENCES, 54(2), 284–294.
author keywords: p-nitrophenol (PNP); toxicokinetics; skin absorption; metabolism; pig
MeSH headings : Administration, Topical; Animals; Area Under Curve; Drug Administration Routes; Female; Injections, Intravenous; Models, Biological; Nitrophenols / administration & dosage; Nitrophenols / pharmacokinetics; Skin / metabolism; Swine; Tissue Distribution
TL;DR:
It was suggested by experimental observation and modeling that urinary 14 C excretion correlates with the systemic tissue depletion profile well and may be used as a biomarker of PNP exposure and supports the strategy of using urinary PNP as a biomonitoring tool for OP pesticide exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 conference paper
Extralabel drug use in the USA and the role of FARAD
7th World Congress of Veterinary Anaesthesiology. Presented at the 7th World Congress of Veterinary Anaesthesiology, Berne, Switzerland.
Event: 7th World Congress of Veterinary Anaesthesiology at Berne, Switzerland on September 20-23, 2000
Source: NC State University Libraries
Added: October 21, 2022
2000 journal article
Extralabel use of ivermectin and moxidectin in food animals
JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 217(5), 668–671.
MeSH headings : Administration, Oral; Administration, Topical; Animals; Animals, Domestic / metabolism; Anthelmintics / administration & dosage; Anthelmintics / pharmacokinetics; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacokinetics; Cattle; Drug Residues / pharmacokinetics; Goats; Injections, Subcutaneous / veterinary; Insecticides / administration & dosage; Insecticides / pharmacokinetics; Ivermectin / administration & dosage; Ivermectin / pharmacokinetics; Macrolides; Sheep; Swine
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 conference paper
FARAD: The Food Animal Residue Avoidance Databank
Proceedings of the 37th Annual Meeting of the Association for Gnotobiotics. Presented at the 37th Annual Meeting of the Association for Gnotobiotics.
Event: 37th Annual Meeting of the Association for Gnotobiotics
Source: NC State University Libraries
Added: April 29, 2023
2000 conference paper
Food Safety, FARAD, and Residue Avoidance in the 6th Millenium
Proceedings of the 8th International Congress of the European Association for Veterinary Pharmacology and Toxicology, 70.
Event: 8th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT) at Jerusalem, Israel on July 10-30, 2000
Source: NC State University Libraries
Added: September 23, 2022
2000 journal article
Food safety, FARAD, and Residue Avoidance in the 6th millenium
Journal of Veterinary Pharmacology and Therapeutics, 23(S1), Q2.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Identification of early biomarkers of inflammation produced by keratinocytes exposed to jet fuels Jet A, JP-8, and JP-8(100)
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 14(5), 231–237.
Contributors: D. Allen n, n & N. Monteiro-Riviere n
author keywords: epidermal keratinocyte; cytokine; jet fuel; biomarkers; inflammation
TL;DR:
It is demonstrated that jet fuels induce the production and release of proinflammatory cytokines in NHEK and thus create the potential for chronic inflammation, which may contribute to the development or progression of disease states in the skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2000 conference paper
Influence of jet fuel mixtures on dermal absorption of aromatic and aliphatic components
The Toxicologist, 54(S1), 151.
Event: 39th Annual Meeting of the Society of Toxicology at Philadelphia, PA on March 19-23, 2000
Source: NC State University Libraries
Added: September 23, 2022
2000 journal article
Membrane transport of naphthalene and dodecane in jet fuel mixtures
Toxicology and Industrial Health, 16(6), 225–238.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2000 journal article
Methods of assessing the percutaneous absorption of volatile chemicals in isolated perfused skin: Studies with chloropentafluorobenzene and dichlorobenzene
TOXICOLOGY METHODS, 10(4), 265–281.
author keywords: chloropentafluorobenzene; dermal absorption; dichlorobenzene; volatile chemicals
TL;DR:
It was found that the effects of solvents on compound absorption that are routinely described in liquid dosing scenarios were also detected when both the compound and solvent were exposed during the vapor phase.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 patent
Methods, systems and products for determining drug withdrawal intervals
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2000 conference paper
Mixed effect modeling applied to the interspecies scaling of gentamicin and oxytetracycline
Proceedings of the 8th International Congress of the European Association for Veterinary Pharmacology and Toxicology, 59.
Event: 8th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT) at Jerusalem, Israel on July 10-30, 2000
Source: NC State University Libraries
Added: September 23, 2022
2000 journal article
Mixed effect modelling applied to the interspecies scaling of gentamicin and oxytetracycline
Journal of Veterinary Pharmacology and Therapeutics, 23(S1), B26.
Source: NC State University Libraries
Added: August 6, 2018
2000 conference paper
Mixture component effects on the percutaneous absorption of TCB, PCB and PCP
The Toxicologist, 54(S1), 150.
Event: 39th Annual Meeting of the Society of Toxicology at Philadelphia, PA on March 19-23, 2000
Source: NC State University Libraries
Added: September 23, 2022
2000 conference paper
Percutaneous absorption and cutaneous toxicity of topically applied Jet A, JP-8, and JP-8 (100)
AFOSR JP-8 Jet Fuel Toxicology Workshop. Presented at the AFOSR JP-8 Jet Fuel Toxicology Workshop, Tucson, AZ.
Event: AFOSR JP-8 Jet Fuel Toxicology Workshop at Tucson, AZ
Source: NC State University Libraries
Added: March 26, 2023
2000 conference paper
Skin cytochrome P450 status and percutaneous penetration: Enhanced dermal absorption and altered local disposition of 3,3’,4,4’-tetrachlorobiphenyl and pentachlorophenol
Perspectives in Percutaneous Penetration, 7A, 115.
Event: Perspectives in Percutaneous Penetration
Source: NC State University Libraries
Added: March 26, 2023
2000 conference paper
The effects of benzo(a)pyrene-induced skin cytochrome P450 elevation on 3,3’,4,4’-tetrachlorobiphenyl percutaneous absorption and tissue disposition
American Industrial Hygiene Conference and Exposition, 56.
Event: American Industrial Hygiene Conference and Exposition at Orlando, FL on May 20-25, 2000
Source: NC State University Libraries
Added: September 23, 2022
2000 conference paper
The impacts of dermal exposure variables on percutaneous penetration and tissue disposition of 3,3’,4,4’-tetrachlorobiphenyl in an ex vivo swine model
Perspectives in Percutaneous Penetration, 7A, 114.
Event: Perspectives in Percutaneous Penetration
Source: NC State University Libraries
Added: March 26, 2023
2000 chapter
Use of antimicrobial agents in the presence of renal impairment
In Antimicrobial therapy in veterinary medicine (3rd ed.) (pp. 453–458). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
2000 conference paper
Use of methyl salicylate as a simulant to predict the percutaneous absorption of sulfur mustard
The Toxicologist, 54(S1), 151–152.
Event: 39th Annual Meeting of the Society of Toxicology at Philadelphia, PA on March 19-23, 2000
Source: NC State University Libraries
Added: September 23, 2022
2000 journal article
Use of the pig as a model to assess cutaneous toxicity and inflammation of jet fuels
Journal of Veterinary Pharmacology and Therapeutics, 23(S1), F12.
Source: NC State University Libraries
Added: August 6, 2018
2000 conference paper
Use of the pig as a model to assess cutaneous toxicity and inflammation of jet fuels
Proceedings of the 8th International Congress of the European Association for Veterinary Pharmacology and Toxicology, 50.
Event: 8th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT) at Jerusalem, Israel on July 10-30, 2000
Source: NC State University Libraries
Added: September 23, 2022
2000 conference paper
Veterinary Pharmacokinetics in the 21st Century
Proceedings of the 8th International Congress of the European Association for Veterinary Pharmacology and Toxicology, 55.
Event: 8th International Congress of the European Association for Veterinary Pharmacology and Toxicology (EAVPT) at Jerusalem, Israel on July 10-30, 2000
Source: NC State University Libraries
Added: September 23, 2022
2000 journal article
Veterinary pharmacokinetics in the 21st century
Journal of Veterinary Pharmacology and Therapeutics, 23(S1), B4.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
A topical formulation containing L tyrosine does not intensify pigmentation in human skin
Journal of Applied Cosmetology, 17, 82–85.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Acute renal failure in four cats treated with paromomycin
Journal of the American Veterinary Medical Association, 215(12), 1821–1823.
Source: NC State University Libraries
Added: August 6, 2018
1999 conference paper
Clustering of JP-8 chemicals using structure spaces and property spaces. A computational approach
Proceedings of the International Conference on Medicinal Chemistry. Presented at the International Conference on Medicinal Chemistry, Biostatistics, New Delhi, India.
Event: International Conference on Medicinal Chemistry at Biostatistics, New Delhi, India
Source: NC State University Libraries
Added: April 29, 2023
1999 book
Comparative Pharmacokinetics: Principles, Techniques, and Applications.
Ames, IA: Blackwell Publishing.
Source: NC State University Libraries
Added: November 21, 2022
1999 conference paper
Compass plots: A joint graphical representation of the factorial design and treatment means
22nd Annual Midwest Biopharmaceutical Statistics Workshop and Summer Research Conference in Statistics. Presented at the 22nd Annual Midwest Biopharmaceutical Statistics Workshop and Summer Research Conference in Statistics, L. A. Pittenger Student Center, Ball State University, Muncie, IN.
Event: 22nd Annual Midwest Biopharmaceutical Statistics Workshop and Summer Research Conference in Statistics at L. A. Pittenger Student Center, Ball State University, Muncie, IN on May 24-26, 1999
Source: NC State University Libraries
Added: December 30, 2022
1999 journal article
Dermal Absorption and Distribution of Topically Dosed Jet Fuels Jet-A, JP-8, and JP-8(100)
Toxicology and Applied Pharmacology, 160(1), 60–75.
Contributors: *, J. Brooks n, N. Monteiro-Riviere n , K. Budsaba n & C. Smith n
author keywords: jet fuel; naphthalene; dodecane; hexadecane; percutaneous/dermal absorption; skin
MeSH headings : Administration, Topical; Aircraft; Alkanes / pharmacokinetics; Animals; Fuel Oils; Naphthalenes / pharmacokinetics; Perfusion; Skin / metabolism; Skin Absorption; Swine
TL;DR:
Different absorption profiles for the three marker compounds, differential effects of jet fuel types on naphthalene and dodecane absorption, and uncoupling of perfusate absorption from skin disposition are demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
1999 conference paper
Dermal absorption and cutaneous disposition of 3,3’,4,4’ tetrachlorobiphenyl (TCB) in swine model
Toxicological Sciences, 48(S1), 73–74.
Event: 38th Annual Meeting of the Society of Toxicology at New Orleans, LA on March 14-18, 1999
Source: NC State University Libraries
Added: December 10, 2022
1999 conference paper
Dermal absorption and toxicity of jet fuels
Toxicological Sciences, 48(S1), 71.
Event: 38th Annual Meeting of the Society of Toxicology at New Orleans, LA on March 14-18, 1999
Source: NC State University Libraries
Added: December 10, 2022
1999 journal article
Drugs prohibited from extralabel use in food animals
Journal of the American Veterinary Medical Association, 215(1), 28–32.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Estimating provisional acceptable residues for extralabel drug use in livestock
REGULATORY TOXICOLOGY AND PHARMACOLOGY, 29(3), 287–299.
MeSH headings : Algorithms; Animals; Drug Residues / adverse effects; Drug Residues / standards; Eating; Eggs; Humans; Legislation, Drug; Meat; Milk; No-Observed-Adverse-Effect Level; Risk Adjustment; United States; Veterinary Drugs / adverse effects; Veterinary Drugs / analysis
TL;DR:
Simulations demonstrated that provided the safe concentrations or equivalent PARs are based on rigorous toxicology safety data, the safety of food animal products will not be compromised and implementing similar transparent methods could have a positive impact on international harmonization and trade.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1999 chapter
Skin
In et al. H. Marquardt (Ed.), Toxicology (pp. 439–457).
Ed(s): e. H. Marquardt
TL;DR:
The mechanisms of direct irritation and sensitization are discussed to provide a basis for selecting appropriate biomarkers for evaluating dermal toxicity, and the general principles of percutaneous penetration, metabolism, and cutaneous responses to specific chemicals are provided.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1999 chapter
Skin
In S. Schafer, H. Marquardt, R. McClellan, & R. Welsch (Eds.), Toxicology (pp. 439–457). New York: Academic Press.
Ed(s): S. Schafer, H. Marquardt, R. McClellan & R. Welsch
Source: NC State University Libraries
Added: October 21, 2022
1999 conference paper
Strategies for estimating provisional acceptable residues (PAR) after extralabel drug use in food animals
Toxicological Sciences, 48(S1), 58.
Event: 38th Annual Meeting of the Society of Toxicology at New Orleans, LA on March 14-18, 1999
Source: NC State University Libraries
Added: December 10, 2022
1999 journal article
The Food Animal Residue Avoidance Databank (Farad): Past, Present and Future
Veterinary Clinics of North America: Food Animal Practice, 15(1), 75–88.
MeSH headings : Animals; Databases, Factual; Drug Residues; Food Contamination; Humans; United States; Veterinary Drugs
TL;DR:
During the last one-and-one-half decades, FARAD has established an unparalleled compilation of residue and pharmacokinetic information for veterinary species, which can be greatly augmented by participation by other nations.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
1999 journal article
Transdermal delivery of testosterone in pigs
AAPS Pharm. Sci, 1, S8.
Source: NC State University Libraries
Added: April 29, 2023
1999 journal article
Transepidermal water loss (TEWL) in pigs. Regional differences and effects of selective lipid extractions
AAPS Pharm. Sci, 1, S228.
Source: NC State University Libraries
Added: April 29, 2023
1998 conference paper
Dermal absorption, distribution and toxicity of topically dosed jet fuels Jet A, JP-8 and JP-8(100)
Presented at the AFOSR JP-8 Jet Fuel Toxicology Workshop, Tucson, AZ.
Event: AFOSR JP-8 Jet Fuel Toxicology Workshop at Tucson, AZ
Source: NC State University Libraries
Added: May 27, 2022
1998 journal article
Enhanced systemic tissue distribution after topical versus intravenous TCB (3,3′, 4,4′-tetrachlorobiphenyl) administered at equivalent doses: A clear example of route dependency in risk assessment
Toxicology Letters, 95, 92.
Source: Crossref
Added: December 24, 2021
1998 conference paper
Extralabel Withdrawal-Interval Estimator (EWE) algorithm. An automated approach to establishing extralabel withdrawal times
Proceedings of the 11th Biennial Symposium of the American Academy of Veterinary Pharmacology and Therapeutics, 49–63.
Event: 11th Biennial of the American Academy of Veterinary Pharmacology and Therapeutics at Monterey, California
Source: NC State University Libraries
Added: November 21, 2022
1998 conference paper
Frontiers in in vitro and in vivo assessment of cutaneous toxicity models for risk assessment
Continuing education course syllabus for the 37th annual meeting of the Society of Toxicology, Seattle, WA, March, 1998, (1998 Mar.).
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Impacts of cutaneous cytochrome P450 induction by benzo[a]pyrene on pentachlorophenol dermal absorption and disposition in three porcine models
Toxicology Letters, 95(Supplement 1), 97.
Source: Crossref
Added: December 24, 2021
1998 conference paper
Impacts of dermal model and exposure variables on risk assessment of 3,3',4,4' tetrachlorobiphenyl (TCB)
Toxicological Sciences, 42(S1), 390.
Source: NC State University Libraries
Added: December 10, 2022
1998 conference paper
In Vitro and In Vivo Assessment of Cutaneous Toxicity Models
In Continuing education course syllabus for the 37th Annual Meeting of the Society of Toxicology. Seattle, WA.
Ed(s): N. Monteiro-Riviere &
Event: 37th Annual Meeting of the Society of Toxicology at Seattle, WA on March 1-5, 1998
Source: NC State University Libraries
Added: December 30, 2022
1998 conference paper
In vitro and in vivo assessment of cutaneous toxicity models
Continuing Education Course Syllabus for the 37th Annual Meeting of the Society of Toxicology, 37.
Source: NC State University Libraries
Added: August 6, 2018
1998 conference paper
Inert ingredients in pesticide mixtures influence the dermal absorption of carbaryl
Toxicological Sciences, 42(S1), 391.
Event: 37th Annual Meeting of the Society of Toxicology at Seattle, WA on March 1-5, 1998
Source: NC State University Libraries
Added: December 10, 2022
1998 journal article
Influence of inert ingredients in pesticide formulations on dermal absorption of carbaryl
American Journal of Veterinary Research, 59(2), 168–175.
Source: NC State University Libraries
Added: August 6, 2018
1998 conference paper
Interspecies extrapolations of data to predict drug effects
135th Annual AVMA Convention Notes, 135, 583–584.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Percutaneous Absorption of Salicylic Acid, Theophylline, 2,4-Dimethylamine, Diethyl Hexyl Phthalic Acid, andp-Aminobenzoic Acid in the Isolated Perfused Porcine Skin Flap Compared to Manin Vivo
Toxicology and Applied Pharmacology, 151(1), 159–165.
MeSH headings : 4-Aminobenzoic Acid / administration & dosage; 4-Aminobenzoic Acid / metabolism; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Anti-Inflammatory Agents / administration & dosage; Anti-Inflammatory Agents / metabolism; Anti-Inflammatory Agents / urine; Carbon Radioisotopes; Diethylhexyl Phthalate / administration & dosage; Diethylhexyl Phthalate / metabolism; Dimethylamines / administration & dosage; Dimethylamines / metabolism; Female; Humans; Macaca mulatta; Male; Middle Aged; Salicylates / administration & dosage; Salicylates / metabolism; Salicylic Acid; Skin Absorption / physiology; Swine; Theophylline / administration & dosage; Theophylline / metabolism
TL;DR:
The IPPSF system appears to be a good model for predicting percutaneous absorption relative to man and should be used to validate other systems to humans in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
1998 chapter
Percutaneous absorption of salicylic acid, theophylline, 2,4-dimethylamine, diethly hexylphthalic acid and p-aminobenzoic acid in the isolated perfused porcine skin flap compared to man
In Percutaneous absorption: drugs, cosmetics, mechanisms, methodology (3rd ed., rev. and expanded) (pp. 571–585). New York: Marcel Dekker.
Source: NC State University Libraries
Added: August 6, 2018
1998 conference paper
Pharmacokinetics for the clinician
Proceedings of the 16th Annual Veterinary Medical Forum, 16, 166–167.
Event: 16th Annual Veterinary Medical Forum at San Diego, CA on May 22-25, 1998
Source: NC State University Libraries
Added: August 6, 2018
1998 conference paper
Pharmacokinetics: A tool for understanding and guiding studies on drugs
Proceedings of the 16th Annual Veterinary Medical Forum, 16, 71–73.
Event: 16th Annual Veterinary Medical Forum at San Diego, CA on May 22-25, 1998
Source: NC State University Libraries
Added: August 6, 2018
1998 conference paper
Population pharmacokinetics in veterinary medicine. Introduction and overview
Proceedings of the 11th Biennial Symposium of the American Academy of Veterinary Pharmacology and Therapeutics, 66–69.
Event: 11th Biennial of the American Academy of Veterinary Pharmacology and Therapeutics at Monterey, California on June 14-19, 1998
Source: NC State University Libraries
Added: August 6, 2018
1998 review
Population pharmacokinetics in veterinary medicine: Potential use for therapeutic drug monitoring and prediction of tissue residues
[Review of ]. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 21(3), 167–189.
MeSH headings : Animals; Dairy Products / analysis; Drug Design; Drug Monitoring / methods; Drug Monitoring / veterinary; Drug Residues; Eggs / analysis; Meat / analysis; Models, Statistical; Statistics, Nonparametric; Tissue Distribution; Veterinary Drugs / pharmacokinetics
TL;DR:
Population pharmacokinetics is an ideal method for generating data in support of the implementation of flexible labelling policies and extralabel drug use recently approved under AMDUCA (Animal Medicinal Drug Use Clarification Act), and statistical methods to validate the population models are necessary.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Population pharmacokinetics of gentamicin in horses
American Journal of Veterinary Research, 59(12), 1589–1598.
Source: NC State University Libraries
Added: August 6, 2018
1998 conference paper
Population pharmacokinetics of gentamicin in horses
Proceedings of the 16th Annual Veterinary Medical Forum, 722.
Event: 16th Annual Veterinary Medical Forum at San Diego, CA
Source: NC State University Libraries
Added: December 10, 2022
1998 journal article
Potential complications associated with normothermic lonidamine infusion and with systemic acidosis in dogs receiving lonidamine during whole body hyperthermia (WBH)
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 14(3), 271–283.
author keywords: lonidamine; whole body hyperthermia; vascular toxicosis; systemic pH; haemorrhage
MeSH headings : Acidosis; Animals; Dogs; Hyperthermia, Induced; Indazoles / adverse effects; Radiation-Sensitizing Agents / adverse effects; Thrombosis / chemically induced; Vasculitis / chemically induced
TL;DR:
The observations confirm the results of in vitro studies which suggest that the combined effect of lonidamine and hyperthermia is enhanced under acidic conditions and indicate that acid-base status of patients receiving l onidamine during WBH must be monitored carefully to avoid serious complications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Prevention of antibiotic residues in veal calves fed colostrum
Journal of the American Veterinary Medical Association, 213(1), 40–42.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Primer on estimating withdrawal times after extralabel drug use
Journal of the American Veterinary Medical Association, 213(7), 966–968.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Role of veterinary therapeutics in bacterial resistance development: animal and public health perspectives
Journal of the American Veterinary Medical Association, 212(8), 1209–1213.
Source: NC State University Libraries
Added: August 6, 2018
1997 conference paper
A novel experimental and modeling paradigm for dermatopharmacokinetics of chemical mixtures using an isolated perfused skin flap preparation
Proceedings Society of Mathematical Biology, 35–36.
Event: Society of Mathematical Biology at Raleigh, NC
Source: NC State University Libraries
Added: April 29, 2023
1997 journal article
Basic principles and techniques of pharmacokinetic modeling
Journal of Zoo and Wildlife Medicine, 28(1), 3–19.
Source: NC State University Libraries
Added: August 6, 2018
1997 conference paper
Compartment models of skin transport: A dominant eigenvalues and sensitivity analysis approach
Proceedings Society of Mathematical Biology, 17–18.
Event: Society of Mathematical Biology at Raleigh, NC
Source: NC State University Libraries
Added: April 29, 2023
1997 conference paper
Cutaneous toxicity of benzidine dye Direct Red 28 applied as a mechanistically-defined chemical mixture (MDCM) in perfused porcine skin
The Toxicologist, 36(S1), 188.
Event: 36th Annual Meeting of the Society of Toxicology at Cincinnati, OH on March 9-13, 1997
Source: NC State University Libraries
Added: December 10, 2022
1997 journal article
Cutaneous toxicity of the benzidine dye direct red 28 applied as mechanistically-defined chemical mixtures (MDCM) in perfused porcine skin
Toxicology Letters, 93(2-3), 159–169.
Contributors: R. Baynes n , N. Monteiro-Riviere n , G. Qiao n & n
author keywords: chemical mixtures; cutaneous toxicity; benzidine dye
MeSH headings : Animals; Benzidines / pharmacokinetics; Benzidines / toxicity; Biomarkers; Coloring Agents / pharmacokinetics; Coloring Agents / toxicity; Dermotoxins / adverse effects; Dermotoxins / pharmacokinetics; Hazardous Waste / adverse effects; In Vitro Techniques; Perfusion; Skin Absorption; Solvents / pharmacokinetics; Solvents / toxicity; Surface-Active Agents / pharmacokinetics; Surface-Active Agents / toxicity; Swine; Toxicity Tests
TL;DR:
It is demonstrated that various mixtures, especially those containing SLS alter the epidermal barrier differently with complex interactions occurring simultaneously.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
1997 journal article
Effect of cutaneous cytochrome p450 induction on pentachlorophenol dermal absorption and disposition in three porcine models
Pharmaceutical Research, 14, S231.
Source: NC State University Libraries
Added: April 29, 2023
1997 journal article
Electrically-assisted transdermal drug delivery
Pharmaceutical Research, 14(6), 687–697.
author keywords: iontophoresis; electrically-assisted delivery; transdermal; electroosmosis; electroporation
MeSH headings : Administration, Cutaneous; Animals; Drug Delivery Systems; Electroporation; Humans; Iontophoresis; Osmosis; Pharmaceutical Preparations / administration & dosage; Skin / metabolism; Skin Absorption
TL;DR:
The focus of this review is to put different mechanisms for EATDD in perspective and relate them to the drug and skin model system being investigated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1997 conference paper
Epidermal cytotoxicity of topically-applied chemical mixtures in perfused porcine skin.
Journal of Veterinary Pharmacology and Therapeutics, 20(S1), 255–256.
Event: 7th European Association for Veterinary Pharmacology & Toxicology at Madrid, Spain on July 6-10, 1997
Source: NC State University Libraries
Added: December 10, 2022
1997 journal article
Evidence that gonadotropin-releasing hormone (GnRH) functions as a prolactin-releasing factor in a teleost fish (Oreochromis mossambicus) and primary structures for three native GnRH molecules
JOURNAL OF ENDOCRINOLOGY, 155(1), 121–132.
MeSH headings : Amino Acid Sequence; Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Culture Techniques; Dose-Response Relationship, Drug; Estradiol / pharmacology; Female; Gonadotropin-Releasing Hormone / chemistry; Gonadotropin-Releasing Hormone / pharmacology; Gonadotropin-Releasing Hormone / physiology; Male; Osmosis; Pituitary Gland / chemistry; Pituitary Gland / drug effects; Prolactin / metabolism; Radioimmunoassay; Stimulation, Chemical; Testosterone / pharmacology; Tilapia / physiology
TL;DR:
The data suggest that GnRH plays a broad role in fish, depending on the species, by affecting not only gonadotropins and growth hormone, but also PRL.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
Extralabel use of nonsteroidal anti inflammatory drugs
Journal of the American Veterinary Medical Association, 211(7), 860–861.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Extralabel use of oxytetracycline
Journal of the American Veterinary Medical Association, 211(1), 42–44.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Extralabel use of tranquilizers and general anesthetics
Journal of the American Veterinary Medical Association, 211(3), 302–304.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
FARAD (the food animal residue avoidance databank): A global perspective
Journal of Veterinary Pharmacology and Therapeutics, 20(S1), 328–329.
Event: 7th European Association for Veterinary Pharmacology & Toxicology at Madrid, Spain on July 6-10, 1997
Source: NC State University Libraries
Added: December 10, 2022
1997 journal article
FARAD Digest: Extralabel use of oxytetracycline
Journal of the American Veterinary Medical Association, 211, 42–44.
Source: NC State University Libraries
Added: December 10, 2022
1997 journal article
FARAD digest: breaking new ground
Journal of the American Veterinary Medical Association, 210, 633–634.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Fluconazole in cats: Pharmacokinetics following intravenous and oral administration and penetration into cerebrospinal fluid, aqueous humour and pulmonary epithelial lining fluid
Journal of Veterinary Pharmacology and Therapeutics, 20(3), 181–186.
MeSH headings : Administration, Oral; Animals; Antifungal Agents / administration & dosage; Antifungal Agents / cerebrospinal fluid; Antifungal Agents / pharmacokinetics; Area Under Curve; Biological Availability; Cats; Chromatography, High Pressure Liquid; Cross-Over Studies; Epithelium / metabolism; Fluconazole / administration & dosage; Fluconazole / cerebrospinal fluid; Fluconazole / pharmacokinetics; Half-Life; Injections, Intravenous; Intestinal Absorption; Lung / metabolism; Male; Random Allocation
TL;DR:
Results of this study suggest fluconazole can effectively be administered to cats at 50 mg per cat per day, as suggested by non-compartmental analysis of data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
1997 journal article
Interspecies allometric analysis of the comparative pharmacokinetics of 44 drugs across veterinary and laboratory animal species
Journal of Veterinary Pharmacology and Therapeutics, 20(6), 453–463.
TL;DR:
Results of this study show that interspecies scaling is applicable to certain veterinary drugs and could have important consequences in terms of avoiding the use of dose-titration studies in Phase I of drug development, for drugs that are experimentally 'well behaved.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
1997 conference paper
Interspecies allometric analysis of the comparative pharmacokinetics of 44 drugs using the FARAD database.
Journal of Veterinary Pharmacology and Therapeutics, 20(S1), 329.
Event: 7th European Association for Veterinary Pharmacology & Toxicology at Madrid, Spain on July 6-10, 1997
Source: NC State University Libraries
Added: December 10, 2022
1997 chapter
Mechanistically defined chemical mixtures: A novel experimental and modelling paradigm for dermal risk assessment of chemical mixtures
In K. R. Brain, V. R. James, & K. A. Walters (Eds.), Perspectives in Percutaneous Penetration (Vol. 5a, p. 26). Cardiff: STS Publishing.
Ed(s): K. Brain, V. James & K. Walters
Source: NC State University Libraries
Added: April 29, 2023
1997 patent
Methods of using topical agents with systematically administered active agents
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1997 conference paper
Modeling the penetration of toxicants through the skin.
The Toxicologist, 36(S1), 204.
Event: 36th Annual Meeting of the Society of Toxicology at Cincinnati, OH on March 9-13, 1997
Source: NC State University Libraries
Added: December 10, 2022
1997 conference paper
Pentachlorophenol (PCP) dermal absorption and disposition in soil with porcine and human models.
The Toxicologist, 36(S1), 189.
Event: 36th Annual Meeting of the Society of Toxicology at Cincinnati, OH on March 9-13, 1997
Source: NC State University Libraries
Added: December 10, 2022
1997 journal article
Pentachlorophenol dermal absorption and disposition from soil in swine: Effects of occlusion and skin microorganism inhibition
TOXICOLOGY AND APPLIED PHARMACOLOGY, 147(2), 234–246.
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Carbon Radioisotopes; Female; Pentachlorophenol / metabolism; Pesticides / metabolism; Skin / drug effects; Skin / metabolism; Skin / microbiology; Skin Absorption; Soil; Soil Pollutants / metabolism; Swine
TL;DR:
Significant dermal absorption and extensive tissue persistence of PCP after soil exposure is demonstrated and exposure-specific PCP absorption and disposition profiles must be taken into consideration in risk analysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1997 report
Percutaneous Absorption of Volatile Chemicals
In (NTIS report AFOSR G49620-95-1-0017) (NTIS Report No. AFOSR FG49620-95-1-0017; pp. 1–23).
TL;DR:
These studies demonstrated dose-dependent absorption of CPFB and DCB in skin which was further modulated by concomitant exposure to vehicle, and could be used as direct input into a systemic risk assessment model.
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1997 conference paper
Percutaneous absorption of DEET and permethrin mixtures applied to skin in vitro: Do they play a role in the “Gulf War Syndrome?"
The Toxicologist, 36(S1), 189.
Event: 36th Annual Meeting of the Society of Toxicology at Cincinnati, OH on March 9-13, 1997
Source: NC State University Libraries
Added: December 10, 2022
1997 chapter
Perfusion models for percutaneous absorption.
In K. R. Brain, V. R. James, & K. A. Walters (Eds.), Perspectives in Percutaneous Penetration (Vol. 5a, p. 5). Cardiff, Wales: STS Publishing, Ltd.
Ed(s): K. Brain, V. James & K. Walters
Source: NC State University Libraries
Added: November 23, 2022
1997 journal article
Pharmacokinetics and ovarian-stimulatory effects of equine and human chorionic gonadotropins administered singly and in combination in the domestic cat
BIOLOGY OF REPRODUCTION, 57(2), 295–302.
MeSH headings : Animals; Cats / physiology; Chorionic Gonadotropin / administration & dosage; Chorionic Gonadotropin / pharmacokinetics; Chorionic Gonadotropin / pharmacology; Estradiol / blood; Female; Gonadotropins / administration & dosage; Gonadotropins / pharmacokinetics; Gonadotropins / pharmacology; Humans; Kinetics; Ovarian Follicle / physiology; Ovary / drug effects; Pregnancy; Progesterone / blood
TL;DR:
It is suggested that hCG promotes the ancillary follicle formation that is frequently observed after ovulation in cats treated with eCG+hCG regimens, possibly disrupting the maternal environment and decreasing fecundity following assisted reproductive procedures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1997 chapter
Pharmacology question contributor
In P. W. Pratt (Ed.), Mosby's review questions and answers for veterinary boards, large animal medicine and surgery. (pp. 175–177, 183–184.). Santa Barbara, CA: Mosby-Year Book, Inc.
Ed(s): P. Pratt
Source: NC State University Libraries
Added: August 6, 2018
1997 conference paper
Population pharmacokinetics of gentamicin in horses.
Journal of Veterinary Pharmacology and Therapeutics, 20(S1), 27–28.
Event: 7th European Association for Veterinary Pharmacology & Toxicology at Madrid, Spain on July 6-10, 1997
Source: NC State University Libraries
Added: December 10, 2022
1997 journal article
Residue avoidance after topical application of veterinary drugs and parasiticides
Journal of the American Veterinary Medical Association, 210(9), 1288–1289.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
The effect of altered media flow and glucose concentration on sulfur-mustard toxicity in the isolated perfused porcine skin flap.
In Vitro Toxicology, 10, 169–181.
Source: NC State University Libraries
Added: November 23, 2022
1997 journal article
The effects of altered media flow and glucose concentration on sulfur mustard toxicity in isolated perfused skin
In Vitro Toxicology, 10(2), 169–181.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
The influence of diethyl-m-toluamide (DEET) on the percutaneous absorption of permethrin and carbaryl
TOXICOLOGY AND APPLIED PHARMACOLOGY, 144(2), 332–339.
MeSH headings : Administration, Cutaneous; Animals; Carbaryl / pharmacokinetics; Chromatography, High Pressure Liquid / methods; DEET / pharmacokinetics; Drug Interactions; Female; Insecticides / pharmacokinetics; Male; Mice; Mice, Inbred C3H; Permethrin; Pyrethrins / pharmacokinetics; Rats; Skin / metabolism; Skin Absorption; Swine
TL;DR:
These studies support DEET, but not permethrin or carbaryl, as having sufficient systemic exposure to potentially cause signs of toxicity when simultaneously applied with pesticides, and demonstrate that DEET does not necessarily enhance dermal absorption of all toxicants as was originally hypothesized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1997 chapter
The isolated perfused porcine skin flap
In Dermatotoxicology methods the laboratory worker's vade mecum (pp. 41–50). Washington, D.C.: Taylor and Francis.
Source: NC State University Libraries
Added: August 6, 2018
1997 chapter
The isolated perfused porcine skin flap.
In F. Marzulli & H. I. Maibach (Eds.), Dermatotoxicology Methods The Laboratory Worker’s Vade Mecum (pp. 41–50). Washington, D.C: Taylor and Francis.
Ed(s): F. Marzulli & H. Maibach
Source: NC State University Libraries
Added: November 23, 2022
1997 journal article
Transdermal peptide delivery using electroporation
Pharmaceutical Biotechnology, 10, 213–238.
Source: NC State University Libraries
Added: April 29, 2023
1997 book
Why our food is safer through science: Fallacies of the "chemical threat"
Fuquay-Varina, NC : Research Triangle Pub.
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
An in vitro-in vivo validation of the isolated perfused tumor and skin flap preparation as a model of cisplatin delivery to tumors
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 35(3), 173–177.
author keywords: cisplatin; isolated perfused tumor and skin flap; isolated perfusion
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Chemotherapy, Cancer, Regional Perfusion / methods; Cisplatin / administration & dosage; Cisplatin / pharmacokinetics; Drug Screening Assays, Antitumor; In Vitro Techniques; Injections, Intralesional; Neoplasms, Experimental / drug therapy; Neoplasms, Experimental / metabolism; Reproducibility of Results; Surgical Flaps; Swine
TL;DR:
Tissue Pt concentrations obtained following systemic administration of cisplatin (CDDP) to whole pigs bearing tumored skin flaps with data obtained from IPTSF treated similarly are compared to that obtained in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1996 conference paper
Comparison of in vivo, ex vivo and in vitro dermal absorption models: Pentachlorophenol (PCP) studies with multiple media
Proceedings Society for Risk Analysis. Presented at the Society for Risk Analysis, New Orleans, LA.
Event: Society for Risk Analysis at New Orleans, LA
Source: NC State University Libraries
Added: April 29, 2023
1996 conference paper
Compartmental models of skin transport: Dominant Eigenvalues approach
1995 Proc. Biometrics Sec., Am. Stat. Assoc., 1995, 449–454.
Source: NC State University Libraries
Added: August 6, 2018
1996 conference paper
Complex chemical mixtures influence the percutaneous absorption of the bladder carcinogen benzidine
Proceedings of the 10th Symposium on Advances in the Biology of the Skin: Pharmacology and Toxicology. Presented at the 10th Symposium on Advances in the Biology of the Skin: Pharmacology and Toxicology, Rutgers University.
Event: 10th Symposium on Advances in the Biology of the Skin: Pharmacology and Toxicology at Rutgers University
Source: NC State University Libraries
Added: April 29, 2023
1996 book
Comprehensive Compendium of Food Animal Drugs: The Food Animal Residue Avoidance Databank Tradename File
(10th ed.). Gainesville, FL: University of Florida Press.
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
Cutaneous metabolism of isosorbide dinitrate after transdermal administration in isolated perfused porcine skin
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 127(2), 213–217.
author keywords: isosorbide dinitrate; isosorbide mononitrate; cutaneous metabolism; IPPSF; skin flap; percutaneous delivery device
TL;DR:
Observations indicate that a fraction of ISDN is biotransformed during transdermal delivery, and this in vitro model possesses a viable epidermis and intact vasculature, two attributes ideal for studying theBiotransformation of a vasoactive drug.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Dose formulation effects on and experimental model differences in dermal absorption and tissue disposition of pentachlorophenol (PCP): In vitro, ExVivo and In Vitro studies
Pharmaceutial Research, 13, S417.
Source: NC State University Libraries
Added: April 29, 2023
1996 journal article
Food animal residue avoidance databank (FARAD)
Journal of the American Veterinary Medical Association, 209, 426.
Source: NC State University Libraries
Added: December 10, 2022
1996 conference paper
Impacts of dermal absorption model on environmental risk assessment: Pentachlorophenol (PCP) studies with three porcine and human skin models
Proceedings of the EPA/HERL Symposium on Susceptibility and Risk Assessment, 5.
Event: EPA/HERL Symposium on Susceptibility and Risk Assessment at Durham, NC
Source: NC State University Libraries
Added: April 29, 2023
1996 conference paper
In vitro percutaneous absorption of benzidine in complex chemical mixtures
The Toxicologist, 30(S1), 170.
Event: 35th Annual Meeting of the Society of Toxicology at Anaheim, CA on March 10-14, 1996
Source: NC State University Libraries
Added: December 10, 2022
1996 journal article
In vitro percutaneous absorption of benzidine in complex mechanistically defined chemical mixtures
TOXICOLOGY AND APPLIED PHARMACOLOGY, 141(2), 497–506.
MeSH headings : Animals; Benzidines / pharmacokinetics; Benzidines / toxicity; Dimethyl Sulfoxide / pharmacology; Perfusion; Skin Absorption; Surface-Active Agents / pharmacology; Swine; Urinary Bladder Neoplasms / chemically induced
TL;DR:
It is proposed that chemical-chemical interactions between benzidine and SnCl2 may be inhibiting benzidine absorption and chemical-biological interactions between M + SL and skin may be enhancing Benzidine absorption.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1996 journal article
Integrated biochemical and molecular mechanism of sulfur mustard vesication in skin: Vascular and basement membrane targets
Medical Defense Bioscience Review, 161.
Source: NC State University Libraries
Added: April 29, 2023
1996 conference paper
Integrated biochemical and molecular mechanisms of sulfur mustard vesication in skin: vascular and basement membrane targets
Proceedings of the 1996 Medical Defense Bioscience Review, 977–986. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.
Source: NC State University Libraries
Added: August 6, 2018
1996 patent
Iontophoretic electrode
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
Isolated perfused porcine skin flap systems
Pharmaceutical Biotechnology, 8, 387–407.
MeSH headings : Administration, Cutaneous; Animals; In Vitro Techniques; Perfusion / methods; Skin / metabolism; Skin Absorption / physiology; Swine
TL;DR:
The anatomical and physiological complexity of human skin is significantly greater than that modeled in existing in vitro systems, which thus do not afford the possibility of detecting these potential biologically relevant events.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
1996 conference paper
Pathogenesis of vesication, percutaneous absorption, and dermatopharmacokinetics of sulfur mustard in isolated perfused porcine skin
Proceedings of the 4th Biennial International Symposium on Alternatives in the Assessment of Toxicity: Issues, Progress and Opportunities, 26.
Event: 4th Biennial International Symposium on Alternatives in the Assessment of Toxicity: Issues, Progress and Opportunities at Aberdeen Proving Ground
Source: NC State University Libraries
Added: April 29, 2023
1996 conference paper
Percutaneous absorption and skin disposition of [14C-UL] pentachlorophenol (PCP) in swine: Dosing vehicle and occlusion effects
The Toxicologist, 30(S1), 168.
Event: 35th Annual Meeting of the Society of Toxicology at Anaheim, CA on March 10-14, 1996
Source: NC State University Libraries
Added: December 10, 2022
1996 journal article
Pharmacokinetic modeling of p-nitrophenol and its conjugation metabolite in swine
Pharmaceutical Research, 13, S417.
Source: NC State University Libraries
Added: April 29, 2023
1996 journal article
Pharmacokinetics and toxicity of oral and intravenous lonidamine in dogs
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 38(2), 129–135.
author keywords: lonidamine; pharmacokinetics; dog
MeSH headings : Administration, Oral; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / blood; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / toxicity; Dogs; Indazoles / administration & dosage; Indazoles / blood; Indazoles / pharmacokinetics; Indazoles / toxicity; Injections, Intravenous; Kinetics; Liver / drug effects; Liver / pathology; Male; Testis / drug effects; Testis / pathology; Vomiting / chemically induced
TL;DR:
The findings suggest that lonidamine is hepatotoxic in dogs, and the dose and route appears to be a viable and controllable method for prospective quantification of l onidamine interaction with systemic chemotherapy and/or hyperthermia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Professional flexible labeling workshop II. Task force report: developing a model of a professional veterinary drug label
Journal of the American Veterinary Medical Association, 209, 83–91.
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
Professional flexible labeling. Task force report II: Response to comments on the proposed model of a professional drug label
Journal of the American Veterinary Medical Association, 209, 268–270.
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
Quantitative percutaneous absorption and cutaneous distribution of binary mixtures of phenol and para-nitrophenol in isolated perfused porcine skin
FUNDAMENTAL AND APPLIED TOXICOLOGY, 32(2), 233–243.
MeSH headings : Animals; In Vitro Techniques; Nitrophenols / pharmacokinetics; Phenol; Phenols / pharmacokinetics; Skin / metabolism; Skin Absorption; Swine; Tissue Distribution
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Quantitative percutaneous absorption and cutaneous distribution of binary mixtures of phenol and -nitrophenol in isolated perfused porcine skin
Fundamental and Applied Toxicology, 32(2), 233–243.
TL;DR:
It is suggested that single chemical data (the compound applied neat) is not predictive of even binary mixtures and that exposure conditions further modulate disposition.
(via Semantic Scholar)
Source: NC State University Libraries
Added: December 10, 2022
1996 conference paper
The food animal residue avoidance databank (FARAD)
Proceedings of the 73rd Meeting of the Southern Branch of the American Dairy Science Association. Presented at the 73rd Meeting of the Southern Branch of the American Dairy Science Association.
Event: 73rd Meeting of the Southern Branch of the American Dairy Science Association
Source: NC State University Libraries
Added: April 29, 2023
1996 chapter
The isolated perfused porcine skin flap
In Dermatotoxicology (5th) (pp. 337–351). Washington, D.C.: Taylor and Francis.
Source: NC State University Libraries
Added: August 6, 2018
1996 chapter
The pig as a model for cutaneous pharmacology and toxicology research
In M. E. Tumbleson & L. B. Schook (Eds.), Advances in swine in biomedical research (pp. 425–458).
Ed(s): . M. E. Tumbleson & L. Schook
TL;DR:
The pig has been a well accepted model for cutaneous absorption and toxicity studies because the integument is morphologically and functionally similar to human skin, and how the pig is utilized in this field is reviewed, with particular reference to studies conducted in the laboratory.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1996 journal article
The use of mechanistically defined chemical mixtures (MDCM) to assess component effects on the percutaneous absorption and cutaneous disposition of topically exposed chemicals .1. Studies with parathion mixtures in isolated perfused porcine skin
TOXICOLOGY AND APPLIED PHARMACOLOGY, 141(2), 473–486.
Contributors: G. Qiao n, J. Brooks n, R. Baynes n, N. MonteiroRiviere n, P. Williams n & n
MeSH headings : Animals; Dimethyl Sulfoxide / pharmacology; Female; Insecticides / pharmacokinetics; Parathion / pharmacokinetics; Perfusion; Risk Assessment; Skin / blood supply; Skin / metabolism; Skin Absorption; Surface-Active Agents / pharmacology; Swine
TL;DR:
This study indicated multiple levels of interactive effects on PA absorption which must be incorporated into any effort to identify critical mechanisms which affect risk assessment of topically exposed mixtures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1996 journal article
The use of mechanistically defined chemical mixtures (MDCM) to assess mixture component effects on the percutaneous absorption and cutaneous disposition of topically exposed chemicals .2. Development of a general dermatopharmacokinetic model for use in risk assessment
TOXICOLOGY AND APPLIED PHARMACOLOGY, 141(2), 487–496.
Contributors: P. Williams n, D. Thompson n, G. Qiao n, N. MonteiroRiviere n & n
MeSH headings : Animals; Models, Biological; Perfusion; Risk Assessment; Skin / metabolism; Skin Absorption; Swine
TL;DR:
This model supports the MDCM concept that defining and then simulating those components of a complex mixture that could have a significant impact on the absorption of a marker toxic compound would be a useful screening approach in the risk assessment of topical chemical mixtures.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1996 conference paper
The use of mechanistically defined chemical mixtures to quantitate parameters of chemical percutaneous absorption using a biologically relevant experimental and mathematical modeling paradigm
Proc. Table Ronde Roussel Uclaf no 85: Passage of Drugs Across Physiological Barriers (Paris), 85, 38–40.
Source: NC State University Libraries
Added: August 6, 2018
1995 journal article
A BIOPHYSICALLY BASED DERMATOPHARMACOKINETIC COMPARTMENT MODEL FOR QUANTIFYING PERCUTANEOUS PENETRATION AND ABSORPTION OF TOPICALLY APPLIED AGENTS .1. THEORY
JOURNAL OF PHARMACEUTICAL SCIENCES, 84(5), 599–608.
MeSH headings : Administration, Topical; Animals; Kinetics; Mathematics; Models, Biological; Permeability; Pharmacokinetics; Phenol; Phenols / pharmacokinetics; Skin Absorption; Swine; Time Factors
TL;DR:
A general comprehensive mathematical model to stimulate and predict percutaneous absorption and subsequent disposition of chemicals in vivo that is chiefly based on biophysical parameters estimated or measured with in vitro and ex vivo perfused skin preparations is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1995 journal article
Absence of whole body hyperthermia effect on cisplatin distribution in spontaneous canine tumors
International Journal of Radiation Oncology*Biology*Physics, 32(4), 1097–1102.
author keywords: HYPERTHERMIA; CISPLATIN; PHARMACOKINETICS; DOGS
MeSH headings : Animals; Cisplatin / pharmacokinetics; Cisplatin / therapeutic use; Combined Modality Therapy / veterinary; Dogs; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Neoplasms / drug therapy; Neoplasms / metabolism; Neoplasms / veterinary; Platinum / metabolism
TL;DR:
Pt disposition was unaffected by WBH under conditions reported in this study, and a forced diuresis is necessary to clinically administer CDDP at maximally tolerable doses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018
1995 chapter
Aminoglycoside antibiotics
In Veterinary pharmacology and therapeutics (7th ed.) (pp. 797–819). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
1995 journal article
An experimental design for assessing ercutaneous absorption of chemical mixtures in isolated perfused porcine skin
Toxicologist, 15, 324.
Source: NC State University Libraries
Added: December 10, 2022
1995 chapter
Antifungal and antiviral drugs
In H. R. Adams (Ed.), Veterinary Pharmacology and Therapeutics (7th ed., pp. 855–883). Ames, Iowa: Iowa State University Press.
Ed(s): H. Adams
Source: NC State University Libraries
Added: August 6, 2018
1995 journal article
Antifungal therapy; ketoconazole and other azole derivatives
Compendium on Continuing Education for the Practicing Veterinarian, 17, 21–31.
Source: NC State University Libraries
Added: August 6, 2018
1995 chapter
Antiseptics/Disinfectants
In H. R. Adams (Ed.), Veterinary Pharmacology and Therapeutics (7th ed., pp. 741–752). Ames, IA: Iowa State University.
Ed(s): H. Adams
Source: NC State University Libraries
Added: August 6, 2018
1995 chapter
Chloramphenicol, erythromycin, quinolones and miscellaneous antibiotics
In Veterinary pharmacology and therapeutics (7th ed.) (pp. 820–854). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
1995 conference paper
Comparative pharmacokinetics and tissue residue of enrofloxacin in weanling swine: Intravenous, intramuscular, and subcutaneous injection studies
Proceedings of the International Symposium of Swine Biomedical Research, 98.
Event: International Symposium of Swine Biomedical Research at College Park, MD
Source: NC State University Libraries
Added: April 29, 2023
1995 journal article
DETECTION OF SULFUR MUSTARD BIS(2-CHLOROETHYL) SULFIDE AND METABOLITES AFTER TOPICAL APPLICATION IN THE ISOLATED-PERFUSED PORCINE SKIN FLAP
LIFE SCIENCES, 56(17), 1385–1394.
Contributors: J. Spoo n, N. Monteiroriviere n & n
author keywords: PIG SKIN; IPPSF; SULFUR MUSTARD; THIODIGLYCOL
TL;DR:
Experiments showed that little, if any, HD appears in the venous perfusate intact after percutaneous absorption and that epidermal metabolism of HD does occur to a significant degree in the IPPSF.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1995 chapter
Dermatopharmacology: drugs acting locally on the skin
In Veterinary pharmacology and therapeutics (7th ed.) (pp. 1050–1090). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
1995 chapter
Drug therapy during renal disease and renal failure
In Canine and feline nephrology and urology (pp. 555–572). Baltimore: Williams and Wilkins.
Source: NC State University Libraries
Added: August 6, 2018
1995 journal article
EFFECT OF WHOLE-BODY HYPERTHERMIA ON LONIDAMINE AND DOXORUBICIN PHARMACOKINETICS AND TOXICITY IN DOGS
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 11(4), 545–559.
author keywords: LONIDAMINE; DOXORUBICIN; WHOLE BODY HYPERTHERMIA; PHARMACOKINETICS; TOXICITY
MeSH headings : Animals; Antineoplastic Agents / blood; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / toxicity; Bile Acids and Salts / blood; Blood Chemical Analysis; Dogs; Doxorubicin / blood; Doxorubicin / pharmacokinetics; Doxorubicin / toxicity; Hyperthermia, Induced; Indazoles / blood; Indazoles / pharmacokinetics; Indazoles / toxicity; Liver / drug effects; Liver / ultrastructure; Metabolic Clearance Rate; Microscopy, Electron; Myocardial Contraction / drug effects; Myocardium / ultrastructure; Vacuoles / drug effects; Vacuoles / ultrastructure
TL;DR:
WBH did not decrease the maximum tolerable dose of doxorubicin when given with lonidamine, and that the antitumour activity of this combination should be assessed, but the biochemical and haematologic toxicities observed did not appear to differ in character or severity from that reported in dogs receiving lonIDamine +/- WBH or doxorbicin +/-WBH.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1995 journal article
EFFECT OF WHOLE-BODY HYPERTHERMIA ON THE PHARMACOKINETICS AND TOXICITY OF LONIDAMINE IN DOGS
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 11(4), 531–544.
author keywords: LONIDAMINE; WHOLE-BODY HYPERTHERMIA; PHARMACOKINETICS; TOXICITY; DOG
MeSH headings : Alanine Transaminase / blood; Alkaline Phosphatase / blood; Amylases / blood; Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / toxicity; Bilirubin / blood; Blood Glucose / metabolism; Carbon Dioxide / blood; Creatine Kinase / blood; Dogs; Hyperthermia, Induced; Hypokalemia / etiology; Indazoles / administration & dosage; Indazoles / blood; Indazoles / pharmacokinetics; Indazoles / toxicity; Liver / drug effects; Liver / pathology; Sialorrhea / etiology; Urea / blood
TL;DR:
The pharmacokinetics and toxicity of intravenous lonidamine were investigated in dogs receiving four cycles of lonidsamine and 400 mg/m2 was identified as the maximum tolerable dose to be administered intravenously to dogs during whole-body hyperthermia (WBH).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1995 journal article
ENHANCING OR BLOCKING EFFECT OF FENVALERATE ON THE SUBSEQUENT PERCUTANEOUS-ABSORPTION OF PESTICIDES IN-VITRO
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 51(3), 214–219.
TL;DR:
The total absorption of these pesticides, both ethanol control and fenvalerate or parathion pretreated, increased proportionally with the dose; however, the absorption efficiency (fraction of applied dose absorbed) decreased as the dose increased.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1995 journal article
EVALUATION OF PROTECTIVE EFFECTS OF SODIUM THIOSULFATE, CYSTEINE, NIACINAMIDE AND INDOMETHACIN ON SULFUR MUSTARD-TREATED ISOLATED-PERFUSED PORCINE SKIN
CHEMICO-BIOLOGICAL INTERACTIONS, 96(3), 249–262.
Contributors: Z. Zhang n, n & N. Monteiroriviere n
author keywords: SULFUR MUSTARD; SODIUM THIOSULFATE; CYSTEINE; NIACINAMIDE; INDOMETHACIN; ISOLATED PERFUSED SKIN; TOXICOLOGY
MeSH headings : Animals; Cysteine / pharmacology; Dinoprostone / metabolism; Female; Indomethacin / pharmacology; Mustard Gas / toxicity; Niacinamide / pharmacology; Skin / blood supply; Skin Diseases / chemically induced; Skin Diseases / pathology; Swine; Thiosulfates / pharmacology
TL;DR:
Data suggest that none of these agents alone would be successful antivesicant agents and different mechanisms are involved in production of HD-induced dark basal cells, microvesicles and the vascular response; unfortunately, blocking of the cellular toxicity as evidenced by dark basal cell formation did not prevent vesication, suggesting that other mechanisms must be operative and that there is a multistep, biochemical process that leads to a final lesion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1995 book
Handbook of comparative veterinary pharmacokinetics and residues of pesticides and environmental contaminants
Boca Raton, FL: CRC Press, Inc.
Source: NC State University Libraries
Added: August 6, 2018
1995 journal article
Isolated perfused porcine skin flap as an in vitro model for predicting transdermal pharmacokinetics
European Journal of Pharmaceutics and Biopharmaceutics, 41, 152–162.
Source: NC State University Libraries
Added: August 6, 2018
1995 journal article
Letter: Proper use of the term model
Journal of the American Veterinary Medical Association, 207, 847.
Source: NC State University Libraries
Added: December 10, 2022
1995 report
Mechanism of cutaneous vesication
In NTIS Report (DAMD No. 17-92C-2071; pp. 1–161).
Source: NC State University Libraries
Added: April 29, 2023
1995 report
Mechanisms of cutaneous vesication
In N. T. I. S. (Ed.), DAMD17-92-C-2071; NTIS, ADA305800 (Vol. 161, pp. 1–161). DAMD 17-92C-2071, NTIS Report, ADA 305800.
Ed(s): Ntis
Source: NC State University Libraries
Added: August 6, 2018
1995 conference paper
Mechanistically defined chemical mixtures (MDCM): A new experimental paradigm for risk assessment applied to skin.
The Toxicologist, 15, 323–324.
Event: 34th Annual Meeting Society of Toxicology at Baltimore, MD on March 5-9, 1995
Source: NC State University Libraries
Added: October 21, 2022
1995 conference paper
Milk and meat withholding times for drugs used extra label: Is it possible to make predictions?
Proceedings of the 132 Annual Meeting American Veterinary Medicine Association, 102.
Event: 132 Annual Meeting American Veterinary Medicine Association
Source: NC State University Libraries
Added: April 29, 2023
1995 journal article
PULSATILE TRANSDERMAL DELIVERY OF LHRH USING ELECTROPORATION - DRUG-DELIVERY AND SKIN TOXICOLOGY
JOURNAL OF CONTROLLED RELEASE, 36(3), 229–233.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1995 chapter
Penicillins and related beta-Lactam antibiotics
In Veterinary pharmacology and therapeutics (7th ed.) (pp. 774–783). Ames: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
1995 chapter
Penicillins and related -Lactam antibiotics.
In H. R. Adams (Ed.), Veterinary Pharmacology and Therapeutics (7th ed., pp. 774–783). Ames, Iowa: Iowa State University Press.
Ed(s): H. Adams
Source: NC State University Libraries
Added: December 10, 2022
1995 conference paper
Percutaneous absorption of parathion applied in mechanistically defined chemical mixtures on isolated perfused porcine skin
The Toxicologist, 15, 324.
Event: 34th Annual Meeting Society of Toxicology at Baltimore, MD on March 5-9, 1995
Source: NC State University Libraries
Added: October 21, 2022
1995 journal article
Pharmacokinetics of cyclosporine in woodchucks and Pekin ducks
Journal of Veterinary Pharmacology and Therapeutics, 18(1), 30–33.
MeSH headings : Animals; Antibodies, Monoclonal; Antibody Specificity; Cyclosporine / administration & dosage; Cyclosporine / blood; Cyclosporine / pharmacokinetics; Ducks / metabolism; Immunosuppression Therapy / veterinary; Injections, Intravenous / veterinary; Marmota / metabolism; Radioimmunoassay / veterinary; Regression Analysis; Species Specificity
TL;DR:
The pharmacokinetic data suggest that Pekin ducks clear Cy at a faster rate than do woodchucks and that a greater dose of Cy should be administered to PekIn ducks in order to achieve adequate immunosuppression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
1995 conference paper
Pharmacology of drug compounding
Proc. Am. Assoc. Avain Pathologists Symposium on Drugs and Therapeutics for Poultry, 39–54.
Source: NC State University Libraries
Added: August 6, 2018
1995 conference paper
Pharmacology of drug compounding in poultry
Proceedings of the 132nd Annual Meeting of the American Veterinary Medicine Association, 110–111.
Event: 132nd Annual Meeting of the American Veterinary Medicine Association
Source: NC State University Libraries
Added: April 29, 2023
1995 journal article
Piroxicam: Evidence for local delivery following topical application
European Journal of Pharmaceutics and Biopharmaceutics, 41, 175–183.
Source: NC State University Libraries
Added: August 6, 2018
1995 journal article
Professional flexible labeling- an AAVPT perspective: part II
Journal of the American Veterinary Medical Association, 207, 876–878.
Source: NC State University Libraries
Added: August 6, 2018
1995 personal communication
Proper use of the term model
Source: NC State University Libraries
Added: August 6, 2018
1995 conference paper
Protective effects of sodium thiosulfate, cysteine, niacinamide and indomethacin on sulfur mustard-treated isolated perfused porcine skin
The Toxicologist, 15, 324.
Event: 34th Annual Meeting Society of Toxicology at Baltimore, MD on March 5-9, 1995
Source: NC State University Libraries
Added: October 21, 2022
1995 conference paper
Quantitative percutaneous absorption and distribution of binary mixtures of two phenols in the isolated perfused porcine skin flap
The Toxicologist, 15, 324.
Event: 34th Annual Meeting Society of Toxicology at Baltimore, MD on March 5-9, 1995
Source: NC State University Libraries
Added: October 21, 2022
1995 chapter
Residues
In Veterinary pharmacology and therapeutics (7th ed.) (pp. 1148–1157). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
1995 journal article
Review of the First Interactive Workshop on Professional Flexible Labeling
Journal of the American Veterinary Medical Association, 207, 865–914.
Source: NC State University Libraries
Added: August 6, 2018
1995 journal article
Significant Effects of Application Site and Occlusion on the Pharmacokinetics of Cutaneous Penetration and Biotransformation of Parathion in Vivo in Swine
Journal of Pharmaceutical Sciences, 84(4), 425–432.
MeSH headings : Adipose Tissue / metabolism; Administration, Topical; Animals; Biotransformation; Epidermis / metabolism; Female; Half-Life; Injections, Intravenous; Models, Biological; Parathion / administration & dosage; Parathion / pharmacokinetics; Skin Absorption / physiology; Swine
TL;DR:
Systemic bioavailability of PA was higher from the back than from the abdomen, and Occlusion not only increased the amount of 14C absorption and shortened the mean residence time in most compartments but also altered the systemic versus cutaneous biotransformation pattern.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018
1995 chapter
Sulfonamides
In Veterinary pharmacology and therapeutics (7th ed.) (pp. 753–773). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
1995 journal article
TOXICOKINETICS OF TOPICAL SULFUR MUSTARD PENETRATION, DISPOSITION, AND VASCULAR TOXICITY IN ISOLATED-PERFUSED PORCINE SKIN
TOXICOLOGY AND APPLIED PHARMACOLOGY, 135(1), 25–34.
Contributors: n, J. Brooks n, P. Williams n & N. Monteiroriviere n
MeSH headings : Animals; Blood Volume / drug effects; Dermatologic Agents / pharmacokinetics; Dermatologic Agents / toxicity; In Vitro Techniques; Models, Biological; Mustard Gas / pharmacokinetics; Mustard Gas / toxicity; Perfusion; Skin / blood supply; Skin / drug effects; Skin Absorption / drug effects; Swine
TL;DR:
A toxicokinetic model is formulated that provides a quantitative profile of the time course of HD disposition within skin which would aid in the interpretation of mechanistic studies of vesication as well as in designing interventive antivesicant drug strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1995 chapter
Tetracyclines
In Veterinary pharmacology and therapeutics (7th ed.) (pp. 784–796). Ames, IA: Iowa State University Press.
Source: NC State University Libraries
Added: August 6, 2018
1995 conference paper
The pig as a model for cutaneous pharmacology and toxicology research
Proceedings of the International Symposium of Swine Biomedical Research, 77.
Event: International Symposium of Swine Biomedical Research at College Park, MD
Source: NC State University Libraries
Added: April 29, 2023
1995 conference paper
The use of mechanistically-defined chemical mixtures to assess component-effects on the percutaneous absorption of parathion in isolated perfused porcine skin
Proceedings of the International Symposium of Swine Biomedical Research, 97.
Event: International Symposium of Swine Biomedical Research at College Park, MD
Source: NC State University Libraries
Added: April 29, 2023
1995 journal article
Topical sulfur mustard induces changes in prostaglandins and interleukin-1? in isolated perfused porcine skin
In Vitro Toxicology, 8, 149–158.
Source: NC State University Libraries
Added: August 6, 2018
1994 article
A FULL-SPACE METHOD FOR PREDICTING IN-VIVO TRANSDERMAL PLASMA DRUG PROFILES REFLECTING BOTH CUTANEOUS AND SYSTEMIC VARIABILITY
WILLIAMS, P. L., & RIVIERE, J. E. (1994, July). JOURNAL OF PHARMACEUTICAL SCIENCES, Vol. 83, pp. 1062–1064.
MeSH headings : Body Fluid Compartments; Computer Simulation; Gonadotropin-Releasing Hormone / blood; Gonadotropin-Releasing Hormone / pharmacokinetics; Humans; Models, Biological; Pharmaceutical Preparations / metabolism; Pharmacokinetics; Predictive Value of Tests; Skin Absorption
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1994 conference paper
An experimental design for assessing percutaneous absorption of chemical mixtures in isolated perfused porcine skin flaps
Proceedings of the Health Effects Research Laboratory (HERL) /Environmental Protection Agency (EPA) Symposium Chemical Mixtures and Quantitative Risk Assessment, 24.
Event: Health Effects Research Laboratory (HERL) /Environmental Protection Agency (EPA) Symposium Chemical Mixtures and Quantitative Risk Assessment at Research Triangle Park, NC
Source: NC State University Libraries
Added: April 29, 2023
1994 journal article
Cutaneous metabolism of isosorbide dinitrate after transdermal administration
Pharmaceutical Research, 11, S190.
Source: NC State University Libraries
Added: April 29, 2023
1994 journal article
Determination of physicochemical properties of phenol, p-nitrophenol, acetone and ethanol relevant to quantitating their percutaneous absorption in porcine skin
Research Communications in Chemical Pathology and Pharmacology, 83, 61–75.
Source: NC State University Libraries
Added: August 6, 2018
1994 journal article
Development and characterization of a novel skin model for cutaneous phototoxicology
Photodermatology, Photoimmunology & Photomedicine, 235–243.
Source: NC State University Libraries
Added: August 6, 2018
1994 conference paper
Development of an in vitro perfused skin model for cutaneous phototoxicity
Vitro Toxicology: Correlations to In Vivo Models / Validation Conference Proceedings. Presented at the Validation Conference, Bethesda, MD.
Event: Validation Conference at Bethesda, MD on April 28-29, 1994
Source: NC State University Libraries
Added: April 29, 2023
1994 journal article
EFFECT OF HYPERTHERMIA ON CISPLATIN AND CARBOPLATIN DISPOSITION IN THE ISOLATED, PERFUSED TUMOR AND SKIN FLAP
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 10(4), 563–572.
author keywords: CISPLATIN; CARBOPLATIN; HYPERTHERMIA; ISOLATED TUMOR PERFUSION
MeSH headings : Animals; Body Temperature Regulation; Carboplatin / administration & dosage; Carboplatin / pharmacokinetics; Cisplatin / administration & dosage; Cisplatin / pharmacokinetics; Combined Modality Therapy; Hyperthermia, Induced; In Vitro Techniques; Neoplasms, Experimental / drug therapy; Neoplasms, Experimental / physiopathology; Neoplasms, Experimental / therapy; Perfusion; Platinum / pharmacokinetics; Surgical Flaps; Swine
TL;DR:
Hyperthermia (HT) alters the disposition of Pt from CDDP and CBDCA under conditions of constant rate infusion, and significantly increased Pt mass in the fixed, non-tumour tissue compartment of CBDCA-treated flaps.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1994 journal article
EFFECT OF WHOLE-BODY HYPERTHERMIA ON CARBOPLATIN DISPOSITION AND TOXICITY IN DOGS
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 10(6), 807–816.
MeSH headings : Animals; Carboplatin / administration & dosage; Carboplatin / pharmacokinetics; Carboplatin / toxicity; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / metabolism; Dog Diseases / therapy; Dogs; Dose-Response Relationship, Drug; Female; Hematopoietic System / drug effects; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Male; Neoplasms / drug therapy; Neoplasms / therapy; Neoplasms / veterinary
TL;DR:
A randomized phase II evaluation should be initiated to determine if a therapeutic gain can be achieved using combined CBDCA and WBH and further refinement of the CBDCA dose in such a trial should be based on both pharmacokinetic parameters and normal tissue response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1994 conference paper
FARAD (The food animal residue avoidance databank) in the 1990's.
Proceedings of the 6th International Congress of the European Association of Veterinary Pharmacology and Toxicology, 72. Pharmacol.Toxicol., Blackwell Press.
Event: International Congress of the European Association of Veterinary Pharmacology and Toxicology
Source: NC State University Libraries
Added: April 29, 2023
1994 book
Handbook of Comparative Pharmacokinetics and Residues of Veterinary Therapeutic Drugs
In Handbook of comparative pharmacokinetics and residues of veterinary therapeutic drugs. Boca Raton, FL: CRC Press, Inc.
Source: NC State University Libraries
Added: August 6, 2018
1994 journal article
Histological evaluation of transdermal electroporation and iontophoresis of LHRH delivery in porcine skin
Pharmaceutical Research, 11, S191.
Source: NC State University Libraries
Added: April 29, 2023
1994 journal article
IDENTIFICATION OF THE PATHWAY OF IONTOPHORETIC DRUG-DELIVERY - LIGHT AND ULTRASTRUCTURAL STUDIES USING MERCURIC-CHLORIDE IN PIGS
PHARMACEUTICAL RESEARCH, 11(2), 251–256.
author keywords: PIGS; IONTOPHORESIS; PATHWAY; DRUG DELIVERY; MERCURIC CHLORIDE; SKIN; LIGHT MICROSCOPY; ELECTRON MICROSCOPY
MeSH headings : Animals; Epidermis / metabolism; Epidermis / ultrastructure; Female; Iontophoresis; Mercuric Chloride / administration & dosage; Mercuric Chloride / pharmacokinetics; Microscopy, Electron; Skin / metabolism; Skin / ultrastructure; Skin Absorption; Swine
TL;DR:
The electron micrographs clearly revealed that mercuric chloride traversed the intact stratum corneum via an intercellular route, having implications for iontophoretic drug delivery, since they allow visualization of the functional "pores" predicted by mathematical models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1994 journal article
Increased transdermal delivery of LHRH in perfused porcine skin by electroporation
Pharmaceutical Research, 11, S190.
Source: NC State University Libraries
Added: April 29, 2023
1994 journal article
Influence of compounding on bioavailability
Journal of the American Veterinary Medical Association, 205, 226–231.
Source: NC State University Libraries
Added: August 6, 2018
1994 conference paper
Interactions in the percutaneous absorption and cutaneous disposition of parathion applied as a chemical mixture in isolated perfused porcine skin flaps
Proceedings of the Health Effects Research Laboratory (HERL) /Environmental Protection Agency (EPA) Symposium Chemical Mixtures and Quantitative Risk Assessment, 26.
Event: Health Effects Research Laboratory (HERL) /Environmental Protection Agency (EPA) Symposium Chemical Mixtures and Quantitative Risk Assessment at Research Triangle Park, NC
Source: NC State University Libraries
Added: April 29, 2023
1994 journal article
Isoelectric Focusing and Capillary Zone Electrophoretic Studies Using Luteinizing Hormone Releasing Hormone and Its Analog
Journal of Pharmaceutical Sciences, 83(5), 654–656.
MeSH headings : Buffers; Chemical Phenomena; Chemistry, Physical; Electrophoresis; Gonadotropin-Releasing Hormone / analogs & derivatives; Gonadotropin-Releasing Hormone / chemistry; Hydrogen-Ion Concentration; Iontophoresis; Isoelectric Focusing; Isoelectric Point
TL;DR:
In the present study, isoelectric focusing and capillary zone electrophoretic studies of luteinizing hormone releasing hormone and one of its analogs are performed in order to predict their ability to be iontophoresed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
1994 conference paper
Maintaining academic creativity in industry related research
In A. D. Jernigan, L. M. Sadler, & S. A. Brown (Eds.), Proceedings of the Ninth Biennial Symposium American Academy of Veterinary Pharmacology and Therapeutics (pp. 159–163).
Ed(s): A. Jernigan, L. Sadler & S. Brown
Event: Ninth Biennial Symposium American Academy of Veterinary Pharmacology and Therapeutics
Source: NC State University Libraries
Added: August 6, 2018
1994 report
Mechanism of cutaneous vesication
(NTIS Report No. DAMD 17-92-C-2071; pp. 1–114).
Source: NC State University Libraries
Added: April 29, 2023
1994 report
Mechanisms of cutaneous vesication
In DAMD17-92-C-2071; NTIS, ADA283085 (Vol. 114, pp. 1–114). DAMD 17-92-C-2071, NTIS Report, ADA 283085.
Source: NC State University Libraries
Added: August 6, 2018
1994 report
Method and Composition for Iontophoresis
(Australian Patent No. 634867).
Source: NC State University Libraries
Added: August 13, 2021
1994 patent
Method and composition for increased skin concentration of active agents by iontophoresis
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1994 patent
Method and composition for iontophoresis
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1994 journal article
PERCUTANEOUS-ABSORPTION, DERMATOPHARMACOKINETICS AND RELATED BIO-TRANSFORMATION STUDIES OF CARBARYL, LINDANE, MALATHION, AND PARATHION IN ISOLATED-PERFUSED PORCINE SKIN
TOXICOLOGY, 91(3), 269–280.
author keywords: PERCUTANEOUS ABSORPTION; PESTICIDE; SKIN FLAP
MeSH headings : Animals; Biotransformation; Carbaryl / pharmacokinetics; Carbaryl / toxicity; Culture Techniques; Hexachlorocyclohexane / pharmacokinetics; Hexachlorocyclohexane / toxicity; Insecticides / pharmacokinetics; Insecticides / toxicity; Malathion / pharmacokinetics; Malathion / toxicity; Microcirculation / metabolism; Parathion / pharmacokinetics; Parathion / toxicity; Perfusion; Skin / blood supply; Skin / drug effects; Skin / metabolism; Skin Absorption; Swine
TL;DR:
Comparison of the metabolic data of P with previous results underscores the difference between non-recirculating and recirculating IPPSF systems in xenobiotic metabolism studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1994 journal article
PHARMACOLOGICAL MODULATION OF THE CUTANEOUS VASCULATURE IN THE ISOLATED-PERFUSED PORCINE SKIN FLAP
JOURNAL OF PHARMACEUTICAL SCIENCES, 83(12), 1682–1689.
MeSH headings : Acetylcholine / pharmacology; Animals; Calibration; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical / methods; Female; Glucose / metabolism; In Vitro Techniques; Infusions, Intra-Arterial; Methylene Blue / pharmacology; Nitroglycerin / pharmacology; Norepinephrine / pharmacology; Perfusion; Pharmacokinetics; Skin / blood supply; Skin / drug effects; Skin / metabolism; Skin Absorption; Swine; Tolazoline / pharmacology; Vascular Resistance / drug effects
TL;DR:
Results indicate that the IPPSF responds to pharmacologic agents in a manner similar to classic in vitro and in vivo models, and would be a relevant model for investigating the delivery and/or toxicity of pharmacologically active compounds.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1994 journal article
PRODUCTION OF 1,25-DIHYDROXYVITAMIN-D-3 BY PERFUSED PIG SKIN
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 102(5), 796–798.
author keywords: 1,25(OH)D-2(3); 24,24(OH)D-2(3); PIG; SKIN; KERATINOCYTES; PERFUSION
MeSH headings : 24,25-Dihydroxyvitamin D 3 / biosynthesis; Animals; Calcitriol / biosynthesis; Chromatography; Culture Media, Serum-Free; Perfusion; Skin / metabolism; Swine; Time Factors
TL;DR:
The skin has the potential to maintain near-normal levels of 1,25 dihydroxyvitamin D3 in the absence of kidneys when provided with adequate substrate, indicating an extrarenal source.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1994 journal article
Percutaneous Absorption of Parathion and Its Metabolites, Paraoxon and p-Nitrophenol, Administered Alone or in Combination: In Vitro Flow-Through Diffusion Cell Studies
Pesticide Biochemistry and Physiology, 48(1), 56–62.
TL;DR:
The percutaneous absorption of parathion relative to its two metabolites, paraoxon and p -nitrophenol, was studied in vitro using weanling pig skin in a flow-through diffusion cell system and both total absorption and absorption efficiency increased as the dose increased.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018
1994 journal article
Percutaneous absorption of topical parathion through porcine skin: in vitro studies on the effect of environmental perturbations
Journal of Veterinary Pharmacology and Therapeutics, 17(6), 434–439.
MeSH headings : Animals; Environment; Female; Humidity; In Vitro Techniques; Models, Statistical; Parathion / metabolism; Parathion / toxicity; Skin / metabolism; Skin Absorption; Swine / metabolism; Temperature
TL;DR:
The results suggest that the factors tested are not independent variables and must be considered interactive when used in assessing pesticide percutaneous absorption in domestic animals such as swine.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018
1994 journal article
Percutaneous absorption, biotransformation and systemic disposition of parathion in vivo in swine. I. Comprehensive pharmacokinetic model
Drug Metabolism and Disposition, 22, 459–471.
Source: NC State University Libraries
Added: August 6, 2018
1994 book review
Pharmaceutical Skin penetration Enhancement by KA Walters and J Hadgraft
[Review of Pharmaceutical Skin penetration Enhancement, by K. A. Walters & J. Hadgraft]. ISSX Newsletter, 13, 14.
Source: NC State University Libraries
Added: April 29, 2023
1994 conference paper
Pharmacokinetics and biotransformation of parathion in vitro and in vivo in swine after topical and intravenous administration
Proceedings of the 6th International Congress of the European Association of Veterinary Pharmacology and Toxicology, 26–27. Blackwell Press.
Event: 6th International Congress of the European Association of Veterinary Pharmacology and Toxicology
Source: NC State University Libraries
Added: April 29, 2023
1994 article
REVIEW OF THE 1993 VETERINARY DRUG BIOEQUIVALENCE WORKSHOP - PREFACE
MARTINEZ, M. N., & RIVIERE, J. E. (1994, April). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 17, pp. 85–119.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1994 journal article
Serum disappearance and urinary excretion of sulfamethoxypyridazine in goats
Revue d'Elevage Et De Medecine Veterinaire Des Pays Tropicaux, 47, 215–218.
Source: NC State University Libraries
Added: August 6, 2018
1994 magazine article
Stop worrying and eat your salad
Riviere, J. E. (1994, August 8). Newsweek, 8.
Source: NC State University Libraries
Added: April 29, 2023
1994 journal article
Stop worrying and eat your salad: science and technology have improved the safety of our food supply
Newsweek, 8.
Source: NC State University Libraries
Added: August 6, 2018
1994 conference paper
Sulfur mustard causes vascular and inflammatory changes in isolated perfused porcine skin
The Toxicologist, 14, 104,
Event: 33rd Annual Meeting of the Society of Toxicology at Dallas, Tx on March 13-17, 1994
Source: NC State University Libraries
Added: October 21, 2022
1994 conference paper
Toxicokinetics of sulfur mustard cutaneous disposition and percutaneous absorption in isolated perfused porcine skin
The Toxicologist, 14, 184.
Event: 33rd Annual Meeting of the Society of Toxicology at Dallas, Tx on March 13-17, 1994
Source: NC State University Libraries
Added: October 21, 2022
1994 journal article
Transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH): Effect of repeated administration
Pharmaceutical Research, 11(7), 1000–1003.
Contributors: M. Heit n, N. Monteiroriviere n, F. Jayes n & n
author keywords: IONTOPHORESIS; PEPTIDE; LHRH; TRANSDERMAL DELIVERY
MeSH headings : Administration, Cutaneous; Animals; Gonadotropin-Releasing Hormone / administration & dosage; Iontophoresis / methods; Radioimmunoassay; Swine
TL;DR:
The transdermal iontophoretic delivery of the reproductive peptide hormone, luteinizing hormone releasing hormone (LHRH) is investigated in the isolated perfused porcine skin flap model (IPPSF) in efforts to identify factors inherent to iontophile delivery that might effect the drug flux of a subsequent iontphoretic episode.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1993 journal article
A biophysically based pharmacokinetic model of percutaneous penetration and absorption
Pharmaceutical Research, 10, S251.
Source: NC State University Libraries
Added: April 29, 2023
1993 chapter
Absorption and distribution
In E. Hodgson & P. Levi (Eds.), Introduction to Biochemical Toxicology (2nd ed., pp. 11–48). Norwalk CT: Appleton and Lange.
Ed(s): E. Hodgson & P. Levi
Source: NC State University Libraries
Added: August 6, 2018
1993 chapter
Antimicrobial prophylaxis
In J. Bojrab (Ed.), Disease Mechanisms in Small Animal Surgery (pp. 66–69). Philadelphia, PA: Lea and Febiger.
Ed(s): J. Bojrab
Source: NC State University Libraries
Added: August 6, 2018
1993 chapter
Biological factors in absorption and permeation
In J. L. Zatz (Ed.), Skin Permeation: Fundamentals and Application (pp. 113–126). Wheaton, IL: Allured Publ., Inc.
Ed(s): J. Zatz
Source: NC State University Libraries
Added: August 6, 2018
1993 conference paper
Changes in metal concentrations in kidney metalothionein following cisplatin and bismuth treatment in F344 rats
The Toxicologist, 13, 133.
Event: 32nd Annual Meeting of the Society of Toxicology at New Orleans, LA on March 14-18, 1993
Source: NC State University Libraries
Added: October 21, 2022
1993 conference paper
Comparison of various models for predicting iontophoresis of arbutamine through human skin
Proceedings of the 20th International Symposium on Controlled Release of Bioactive Materials, 20.
Event: 20th International Symposium on Controlled Release of Bioactive Materials at Washington, DC on July 25-30, 1993
Source: NC State University Libraries
Added: April 29, 2023
1993 conference paper
Comprehensive pharmacokinetic model of topical parathion percutaneous absorption, systemic disposition and biotransformation integrating in vivo, in vitro diffusion cell, and isolated perfused porcine skin flap (IPPSF) data
The Toxicologist, 13, 50.
Event: 32nd Annual Meeting of the Society of Toxicology at New Orleans, LA on March 14-18, 1993
Source: NC State University Libraries
Added: October 21, 2022
1993 conference paper
Controlled drug delivery across the skin to subcutaneous tissue
Proceedings of the 20th International Symposium on Controlled Release of Bioactive Materials. Presented at the 20th International Symposium on Controlled Release of Bioactive Materials, Washington, DC.
Event: 20th International Symposium on Controlled Release of Bioactive Materials at Washington, DC on July 25-30, 1993
Source: NC State University Libraries
Added: April 29, 2023
1993 journal article
Cutaneous toxicity of mustard and lewisite on the isolated perfused skin flap
Medical Chemical Defense, 6(1), 16.
Source: NC State University Libraries
Added: April 29, 2023
1993 journal article
Development and characterization of an isolated and perfused tumor and skin preparation for evaluation of drug disposition
Cancer Research, 53, 101–105.
Source: NC State University Libraries
Added: August 6, 2018
1993 journal article
Development of in vitro isolated perfused porcine skin flaps for study of percutaneous absorption of xenobiotics
Medical Chemical Defense, 6(1), 15–16.
Source: NC State University Libraries
Added: April 29, 2023
1993 article
EFFECT OF HUMIDITY AND OCCLUSION ON THE PERCUTANEOUS-ABSORPTION OF PARATHION INVITRO
CHANG, S. K., & RIVIERE, J. E. (1993, January). PHARMACEUTICAL RESEARCH, Vol. 10, pp. 152–155.
author keywords: HUMIDITY; PERCUTANEOUS ABSORPTION; PARATHION
MeSH headings : Animals; Female; Humidity; In Vitro Techniques; Parathion / administration & dosage; Parathion / pharmacokinetics; Skin / blood supply; Skin Absorption / physiology; Swine
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1993 journal article
EFFECT OF TUMOR PRESENCE ON CISPLATIN AND CARBOPLATIN - DISPOSITION IN THE ISOLATED, PERFUSED TUMOR AND SKIN FLAP
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 32(1), 31–38.
author keywords: CISPLATIN; CARBOPLATIN; ISOLATED TUMOR PERFUSION
MeSH headings : Animals; Carboplatin / administration & dosage; Carboplatin / pharmacokinetics; Chemotherapy, Cancer, Regional Perfusion / instrumentation; Choriocarcinoma; Cisplatin / administration & dosage; Cisplatin / pharmacokinetics; Humans; Models, Biological; Platinum / analysis; Skin / metabolism; Swine; Tumor Cells, Cultured / metabolism; Vascular Resistance
TL;DR:
It is concluded that the IPTSF is a useful model for evaluating the disposition of Pt drugs in tumor and non-tumor tissue and that tumor presence alters the disposing of CDDP.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1993 journal article
Effects of Anatomical Site and Occlusion on the Percutaneous Absorption and Residue Pattern of 2,6-(ring-14C)Parathion in Vivo in Pigs
Toxicology and Applied Pharmacology, 122(1), 131–138.
MeSH headings : Abdomen; Administration, Topical; Animals; Back; Buttocks; Drug Residues; Feces / chemistry; Female; Injections, Intravenous; Parathion / administration & dosage; Parathion / pharmacokinetics; Parathion / toxicity; Shoulder; Skin Absorption; Swine; Tissue Distribution
TL;DR:
The effects of anatomical site and occlusion on the percutaneous absorption and residue pattern of total 14C were investigated following topical application of 2,6-[ring-14C]parathion onto four skin sites in weanling swine using occluded and nonoccluded dosing systems, with shoulder and buttocks being similar, and the back the highest.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018
1993 chapter
Grafted skin and skin flaps
In Topical drug bioavailability, bioequivalence and penetration (pp. 209–221).
TL;DR:
The ultimate goal of many in vitro and in vivo drug and xenobiotic percutaneous absorption studies in animals is to predict penetration in humans, and the optimal approach would be a quantitative one that not only would precisely predict chemical disposition in humans but also would allow to determine the effect of different formulation, environmental, and dermatological variables on the rate and extent of dermal penetration.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
1993 journal article
KIDNEY TRACE-METAL RESPONSE TO COMBINED CISPLATIN (CDDP) AND HYPERTHERMIA
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 9(4), 529–537.
author keywords: HYPERTHERMIA; CISPLATIN; KIDNEYS; COPPER
MeSH headings : Animals; Blood Urea Nitrogen; Copper / metabolism; Creatinine / blood; Female; Hot Temperature / adverse effects; Kidney / drug effects; Kidney / metabolism; Organoplatinum Compounds / toxicity; Platinum / metabolism; Rats; Rats, Inbred F344; Trace Elements / metabolism; Zinc / metabolism
TL;DR:
It is demonstrated that systemic hyperthermia significantly increases CDDP nephrotoxicity in F344 rats and that kidney copper loss from CDDP exposure athyperthermia is similar to the loss observed from CD DP at normothermia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1993 journal article
MODEL DESCRIBING TRANSDERMAL IONTOPHORETIC DELIVERY OF LIDOCAINE INCORPORATING CONSIDERATION OF CUTANEOUS MICROVASCULAR STATE
JOURNAL OF PHARMACEUTICAL SCIENCES, 82(11), 1080–1084.
MeSH headings : Administration, Cutaneous; Animals; Iontophoresis; Lidocaine / administration & dosage; Lidocaine / pharmacokinetics; Models, Biological; Norepinephrine / pharmacology; Perfusion; Skin / blood supply; Skin Absorption; Swine; Tolazoline / pharmacology
TL;DR:
The model presented was able to predict 8-h lidocaine absorptions and compartmental mass profiles for each of the three treatments, was ableTo document vascular effects of co-iontophoresed vasoactive compounds, and gives insight into the factors that modulate cutaneous disposition of iontophoretically delivered lidocane in a biologically relevant model approximating in vivo delivery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1993 report
Method and Composition for Increased Skin Concentration of Active Agents by Iontophoresis
(Australian Patent No. 643760B2).
Source: NC State University Libraries
Added: August 13, 2021
1993 journal article
Modulation of cutaneous vascular resistance in the isolated perfused porcine skin flap
Pharmaceutical Research, 10, S250.
Source: NC State University Libraries
Added: April 29, 2023
1993 journal article
Novel In Vitro model to assess UVB phototoxicity
Pharmaceutical Research, 10, S250.
Source: NC State University Libraries
Added: April 29, 2023
1993 journal article
Percutaneous absorption, biotransformation, and systemic disposition of topical parathion in vivo in swine
Pharmaceutical Research, 10, S251.
Source: NC State University Libraries
Added: April 29, 2023
1993 journal article
Pharmacokinetic and Phase I Evaluation of Carboplatin in Dogs
Journal of Veterinary Internal Medicine, 7(4), 235–240.
MeSH headings : Animals; Carboplatin / administration & dosage; Carboplatin / pharmacokinetics; Carboplatin / therapeutic use; Carboplatin / toxicity; Dog Diseases / drug therapy; Dogs; Dose-Response Relationship, Drug; Female; Half-Life; Infusions, Intravenous / veterinary; Leukocyte Count / veterinary; Male; Neoplasms / drug therapy; Neoplasms / veterinary; Neutrophils / drug effects; Platelet Count / veterinary; Regression Analysis
TL;DR:
Dose-independent serum CBDCA pharmacokinetic disposition indicates that detailed investigation of tissue CBDCA distribution would be warranted and may identify novel dosing strategies that could improve the therapeutic index of CBDCA by minimizing toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018
1993 chapter
Skin: Porcine Skin Flaps
In C. A. Tyson & J. M. Frazier (Eds.), Methods in Toxicology, In Vitro Biological Systems (Vol. 1, pp. 515–524). New York: Academic Press.
Ed(s): C. Tyson & J. Frazier
Source: NC State University Libraries
Added: April 29, 2023
1993 conference paper
Studies on the pathogenesis of bis(2-chloroethyl) sulfide (HD) induced vesication in porcine skin
Proceedings of the 8th Medical Defense Bioscience Review, I, 31–40. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.
Event: 8th Medical Defense Bioscience Review
Source: NC State University Libraries
Added: August 6, 2018
1993 journal article
Studies on the pathogenesis of bis(2-chloroethyl) sulfide (HD) induced vesication in porcine skin
Chemical Defense Bioscience Review, 33.
Source: NC State University Libraries
Added: April 29, 2023
1993 journal article
TRANSDERMAL LONTOPHORETIC PEPTIDE DELIVERY - INVITRO AND INVIVO STUDIES WITH LUTEINIZING-HORMONE-RELEASING HORMONE
JOURNAL OF PHARMACEUTICAL SCIENCES, 82(3), 240–243.
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1993 conference paper
The use of isolated perfused skin models for quantitating transdermal drug delivery
Proceedings of the 2nd Transdermal Delivery Systems Technology Symposium, 2, 71–86. Bunkashoin.
Event: 2nd Transdermal Delivery Systems Technology Symposium at Tokyo
Source: NC State University Libraries
Added: August 6, 2018
1993 journal article
Topical penetration of piroxicam is dependent on the distribution of the local cutaneous vasculature
Pharmaceutical Research, 10, 1326–1331.
MeSH headings : Animals; Diffusion; Female; Piroxicam / pharmacokinetics; Regional Blood Flow / physiology; Skin / blood supply; Skin Absorption / physiology; Swine
TL;DR:
In conclusion, local delivery of topical drugs occurs independent of systemic absorption and the nature of the cutaneous vasculature at different sites must be taken into consideration for optimal delivery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018
1993 chapter
Use of antimicrobial agents in the presence of renal impairment
In J. F. Prescott & J. D. Baggot (Eds.), Antimicrobial Therapy in Veterinary Medicine (pp. 365–370). Ames, IA: Iowa State Univ. Press.
Ed(s): J. Prescott & J. Baggot
Source: NC State University Libraries
Added: August 6, 2018
1993 conference paper
Use of isolated perfused equine skin flaps to assess effects of vehicle and application site on percutaneous absorption of chemicals
American College of Veterinary Surgeons 28th Annual Meeting. Poster presented at the American College of Veterinary Surgeons 28th Annual Meeting, San Francisco, CA.
Event: American College of Veterinary Surgeons 28th Annual Meeting at San Francisco, CA
Source: NC State University Libraries
Added: November 21, 2022
1992 journal article
A new hypothesis for the mechanism of local enhanced delivery of topically applied drugs to the underlying musculature
Pharmaceutical Research, 9, S169.
Source: NC State University Libraries
Added: April 29, 2023
1992 journal article
CARDIOVASCULAR EFFECTS AND FATALITIES ASSOCIATED WITH INTRAVENOUS ADMINISTRATION OF DOXYCYCLINE TO HORSES AND PONIES
EQUINE VETERINARY JOURNAL, 24(1), 41–45.
MeSH headings : Animals; Blood Pressure / drug effects; Cardiovascular System / drug effects; Doxycycline / administration & dosage; Doxycycline / adverse effects; Electrocardiography / veterinary; Electrolytes / blood; Female; Heart / drug effects; Heart Rate / drug effects; Horses / physiology; Infusions, Intravenous / veterinary; Male; Muscles / drug effects; Respiration / drug effects
TL;DR:
Results of the present study suggest that the intravenous use of doxycycline should be avoided in horses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1992 journal article
CHARACTERIZATION OF LEWISITE TOXICITY IN ISOLATED PERFUSED SKIN
TOXICOLOGY AND APPLIED PHARMACOLOGY, 116(2), 189–201.
Contributors: . King n, n & N. Monteiroriviere n
MeSH headings : Administration, Topical; Animals; Arsenic / blood; Arsenic Poisoning; Arsenicals / pharmacokinetics; Female; Glucose / metabolism; Histocytochemistry; In Vitro Techniques; Kinetics; L-Lactate Dehydrogenase / drug effects; L-Lactate Dehydrogenase / metabolism; Microscopy; Perfusion; Skin / blood supply; Skin / drug effects; Skin / metabolism; Skin Absorption; Swine; Time Factors; Vascular Resistance / drug effects
TL;DR:
The sensitivity of the IPPSF to L exposure and the similarity of lesions to those described for humans suggests that this model provides a relevant in vitro model with which to study mechanisms of chemical vesication and arsenic toxicity, as well as protective and therapeutic intervention for vesicant exposure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1992 journal article
CISPLATIN-INDUCED LOSS OF KIDNEY COPPER AND NEPHROTOXICITY IS AMELIORATED BY SINGLE DOSE DIETHYLDITHIOCARBAMATE, BUT NOT MESNA
TOXICOLOGY AND APPLIED PHARMACOLOGY, 112(2), 182–189.
MeSH headings : Animals; Blood Urea Nitrogen; Body Weight / drug effects; Cisplatin / toxicity; Copper / metabolism; Creatinine / blood; Ditiocarb / therapeutic use; Female; Kidney / drug effects; Kidney / metabolism; Kidney Diseases / chemically induced; Kidney Diseases / metabolism; Kidney Diseases / prevention & control; Mesna / therapeutic use; Platinum / metabolism; Rats; Rats, Inbred F344; Zinc / metabolism
TL;DR:
The patterns of copper loss and toxicity from CDDP alone or with DDC suggest that copper be further evaluated for its role in the mechanism of CDDP cytotoxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1992 journal article
CUTANEOUS TOXICITY AND ABSORPTION OF PARAQUAT IN PORCINE SKIN
TOXICOLOGY AND APPLIED PHARMACOLOGY, 115(1), 89–97.
Contributors: V. Srikrishna n, n & N. Monteiroriviere n
MeSH headings : Acid Phosphatase / metabolism; Alkaline Phosphatase / metabolism; Animals; Edema / chemically induced; Esterases / metabolism; Female; Glucose / metabolism; In Vitro Techniques; Microscopy, Electron; Paraquat / pharmacokinetics; Paraquat / toxicity; Skin / drug effects; Skin / metabolism; Skin / ultrastructure; Skin Absorption; Swine
TL;DR:
At high concentrations and prolonged exposure, paraquat may have deleterious effects on epidermal morphology in the absence of significant percutaneous absorption and Radiotracer studies indicated that a majority of the compound remained on top of the application site and minimal absorption or penetration into skin was observed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1992 journal article
DETERMINATION OF LIDOCAINE CONCENTRATIONS IN SKIN AFTER TRANSDERMAL IONTOPHORESIS - EFFECTS OF VASOACTIVE DRUGS
PHARMACEUTICAL RESEARCH, 9(2), 211–214.
Contributors: n, N. Monteiroriviere n & A. Inman n
author keywords: LIDOCAINE; IONTOPHORESIS; TRANSDERMAL; PERCUTANEOUS ABSORPTION; SKIN DEPOT
MeSH headings : Administration, Cutaneous; Animals; Electrodes; Female; Iontophoresis; Lidocaine / analysis; Lidocaine / pharmacokinetics; Models, Biological; Norepinephrine / pharmacology; Skin / anatomy & histology; Skin / chemistry; Skin / drug effects; Skin Absorption / drug effects; Swine / metabolism; Tolazoline / pharmacology; Vasoconstrictor Agents / pharmacology; Vasodilator Agents / pharmacology
TL;DR:
The hypothesis that coiontophoresis of vasoactive drugs modulates the transdermal delivery of lidocaine, in part by altering the cutaneous “depot,” is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1992 chapter
Dermal absorption and metabolism of xenobiotics in food producing animals
In Xenobiotics in food producing animals: metabolism and residues (Vol. 503, pp. 88–97).
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
1992 book
Educational Perspectives in Preparation for the 21st Century: Proceedings of the Seventh Biennial Symposium American Academy of Veterinary Pharmacology and Therapeutics
Raleigh, NC.
Ed(s): A. Aronson &
Source: NC State University Libraries
Added: April 29, 2023
1992 conference paper
Educational perspectives in preparation for the 21st century : proceedings of the seventh biennial symposium, American Academy of Veterinary Pharmacology and Therapeutics, Raleigh, North Carolina, June 12-16, 1990
Conference Proceedings, 7.
Source: NC State University Libraries
Added: August 6, 2018
1992 conference paper
Effect of vehicle and application site on absorption of chemicals through equine skin
Proceedings, 38th Annual Convention of the American Association of Equine Practitioners, 38, 725.
Source: NC State University Libraries
Added: August 6, 2018
1992 book
Food Animal Residue Avoidance Databank trade name file: a comprehensive compendium of food animal drugs
(p. 457). Gainesville, FL: University of Florida Press.
Source: NC State University Libraries
Added: August 6, 2018
1992 review
MODEL SYSTEMS IN IONTOPHORESIS TRANSPORT EFFICACY
[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 9(2-3), 265–287.
author keywords: CONTROLLED RELEASE; ELECTROCHEMICAL REACTION; INVITRO TRANSPORT; INVIVO TRANSPORT; IONTOPHORESIS; ION TRANSPORT; NOVEL DRUG DELIVERY; PATIENT-CONTROLLED ANALGESIA; TRANSDERMAL
TL;DR:
Comparative studies using experimental model systems show that systems based on excised skin can significantly underestimate drug flux achievable in vivo under identical formulation and electrical conditions and that the isolated perfused porcine skin flap model accurately predicts in vivo drug flux.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1992 chapter
New models in skin research: The Isolated Perfused Porcine Skin Flap
In R. Wang, J. Knack, & H. Maibach (Eds.), Health Risk Assessment: Dermal and Inhalational Exposure and Absorption of Toxicants (pp. 439–452). Boca Raton, FL: CRC Press.
Ed(s): R. Wang, J. Knack & H. Maibach
Source: NC State University Libraries
Added: August 6, 2018
1992 personal communication
PHARMACOKINETIC IMPLICATIONS OF CHANGING BLOOD-FLOW IN SKIN
RIVIERE, J. E., & WILLIAMS, P. L. (1992, June).
MeSH headings : Humans; Microcirculation; Pharmacokinetics; Regional Blood Flow; Skin / blood supply; Skin Absorption
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1992 journal article
Practical aspects of the pharmacology of drug residue prevention in food animals
Agri-Practice, 13, 11–16.
Source: NC State University Libraries
Added: August 6, 2018
1992 journal article
Predicting percutaneous absorption
Acta Pharmaceutica Nordica, 4, 119–120.
Source: NC State University Libraries
Added: April 29, 2023
1992 journal article
Predicting percutaneous absorption.
Acta Pharmaceutica Nordica, 4, 119–120.
Source: NC State University Libraries
Added: November 23, 2022
1992 journal article
Predictions of the in vivo transdermal iontophoretic delivery of luteinizing hormone releasing hormone (LHRH) based on in vitro flux
Pharmaceutical Research, 9, S191.
Source: NC State University Libraries
Added: April 29, 2023
1992 journal article
Prostaglandins in isolated perfused skin treated with sulfur mustard
Pharmaceutical Research, 9, S232.
Source: NC State University Libraries
Added: April 29, 2023
1992 journal article
QUANTITATIVE PREDICTION OF TRANSDERMAL IONTOPHORETIC DELIVERY OF ARBUTAMINE IN HUMANS WITH THE INVITRO ISOLATED PERFUSED PORCINE SKIN FLAP
JOURNAL OF PHARMACEUTICAL SCIENCES, 81(6), 504–507.
MeSH headings : Administration, Cutaneous; Animals; Cardiotonic Agents / administration & dosage; Cardiotonic Agents / pharmacokinetics; Catecholamines / administration & dosage; Catecholamines / pharmacokinetics; Chromatography, High Pressure Liquid; Electrodes; Humans; In Vitro Techniques; Infusions, Intravenous; Iontophoresis; Male; Swine
TL;DR:
The use of the isolated perfused porcine skin flap (IPPSF), an alternative in vitro animal model, to predict the profile of the concentration of arbutamine in plasma samples from humans after transdermal iontophoretic administration of this novel catecholamine is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1992 conference paper
Role of veterinary pharmacologists in academia in the 1990's
Proc. Seventh Biennial Symp. Am. Acad. Vet. Pharmacol. Therap., 7, 39–42.
Source: NC State University Libraries
Added: August 6, 2018
1992 conference paper
The effects of hyperthermia and tumor presence on cisplatin uptake in an isolated, perfused tumor and skin flap
Proceedings of the American Association for Cancer Research Annual Meeting, 33, 531.
Event: American Association for Cancer Research Annual Meeting
Source: NC State University Libraries
Added: April 29, 2023
1992 chapter
Transdermal penetration and metabolism of organophosphate insecticides
In Organophosphates: chemistry, fate and effects (pp. 241–253).
Source: NC State University Libraries
Added: August 6, 2018
1991 journal article
A pharmacokinetic model describing iontophoretic drug delivery and subsequent disposition of lidocaine in the isolated perfused porcine skin flap (IPPSF)
Pharmaceutical Research, 8, S292.
Source: NC State University Libraries
Added: April 29, 2023
1991 review
COMPARATIVE PHARMACOKINETICS OF AMINOGLYCOSIDE ANTIBIOTICS
[Review of ]. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 14(1), 1–35.
MeSH headings : Aminoglycosides; Animals; Anti-Bacterial Agents / pharmacokinetics; Half-Life; Humans; Kidney / drug effects; Kidney / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1991 conference paper
Characterization of lewisite vesication in isolated perfused porcine skin
Proceedings of the 1991 Annual Chemical Defense Bioscience Review, 30. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.
Event: 1991 Annual Chemical Defense Bioscience Review at Aberdeen Proving Ground, MD
Source: NC State University Libraries
Added: August 6, 2018
1991 conference paper
Characterization of the cutaneous vascular response to topically applied sulfur mustard and lewisite
Proceedings of the 1991 Medical Defense Bioscience Review, 29. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.
Event: 1991 Medical Defense Bioscience Review at Aberdeen Proving Ground, MD
Source: NC State University Libraries
Added: August 6, 2018
1991 book
Comprehensive Compendium of Food Animal Drugs: The Food Animal Residue Avoidance Databank Tradename File
(6th ed.). Gainesville, Florida: University of Florida Press.
Source: NC State University Libraries
Added: August 13, 2021
1991 journal article
Cutaneous laser Doppler velocimetry in nine animal species
American Journal of Veterinary Research, 52(12), 1960–1964.
Source: NC State University Libraries
Added: August 6, 2018
1991 report
Cutaneous toxicity of mustard and lewisite on the isolated perfused porcine skin flap
In DAMD17-87-C-7139; NTIS, ADA254419 (pp. 1–140).
Source: NC State University Libraries
Added: August 6, 2018
1991 conference paper
Dermal absorption and metabolism of xenobiotics in food producing animals
Proceedings of the 4th Chemical Congress of North America. Presented at the 4th Chemical Congress of North America.
Event: 4th Chemical Congress of North America
Source: NC State University Libraries
Added: April 29, 2023
1991 journal article
Development of surgical techniques for preparation of in vitro isolated perfused porcine skin flaps for percutaneous absorption studies
American Journal of Veterinary Research, 52, 75–82.
Source: NC State University Libraries
Added: August 6, 2018
1991 journal article
EFFECT OF HYPERTHERMIA ON THE INVITRO HYDROLYSIS OF MELPHALAN
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 7(3), 527–529.
author keywords: NORMOTHERMIC; HYPERTHERMIC; HYDROLYSIS; MELPHALAN
MeSH headings : Animals; Dogs; Hot Temperature; Hydrolysis; In Vitro Techniques; Melphalan / blood; Melphalan / pharmacokinetics; Swine
TL;DR:
The pharmacokinetics of melphalan was investigated at 37 degrees C and 42 degrees C in vitro in canine and porcine plasma to assess heat-induced changes in the in vivo rate ofmelphalan hydrolysis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1991 journal article
EFFECTS OF VASOACTIVE DRUGS ON TRANSDERMAL LIDOCAINE IONTOPHORESIS
JOURNAL OF PHARMACEUTICAL SCIENCES, 80(7), 615–620.
MeSH headings : Administration, Cutaneous; Animals; Diffusion; Humans; In Vitro Techniques; Iontophoresis; Lidocaine / administration & dosage; Lidocaine / pharmacokinetics; Microcirculation / drug effects; Norepinephrine / pharmacokinetics; Perfusion; Swine; Tolazoline / pharmacokinetics; Vasodilator Agents / pharmacology
TL;DR:
It is demonstrated that co-iontophoresis of vasoactive compounds may significantly alter the transdermal delivery of lidocaine and that use of vitro animal model systems which possess a functional microcirculation are essential to study this process if reliable extrapolation to the in vivo setting is desired.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1991 conference paper
Effect of anesthesia and whole body hyperthermia (WBH) on cisplatin (CDDP) and carboplatin (CBDCA) tissue distribution
In J. D. Chapman (Ed.), Radiation research : a twentieth-century perspective; [proceedings of the 9th International Congress of Radiation Research, held in Toronto, Canada in July 1991]. San Diego, California: San Diego Academic Press.
Ed(s): J. Chapman
Event: 9th International Congress of Radiation Research at Toronto, Canada
Source: NC State University Libraries
Added: August 13, 2021
1991 journal article
Effect of humidity on percutaneous absorption of parathion in vitro
Pharmaceutical Research, 8, S203.
Source: NC State University Libraries
Added: April 29, 2023
1991 journal article
Effects of dosing sites on the toxicokinetics of parathion in pigs
Pharmaceutical Research, 8, S285.
Source: NC State University Libraries
Added: April 29, 2023
1991 journal article
FARAD - The Food Animal Residue Avoidance Databank
Extension Review, 62, 16.
Source: NC State University Libraries
Added: August 6, 2018
1991 report
FARAD: Food Animal Residue Avoidance Databank
In FACTSHEET. Washington, DC: USDA Extension Service.
Source: NC State University Libraries
Added: August 6, 2018
1991 article
INVIVO PERCUTANEOUS PENETRATION ABSORPTION, WASHINGTON, DC, MAY 1989
SHAH, V. P., FLYNN, G. L., GUY, R. H., MAIBACH, H. I., SCHAEFER, H., SKELLY, J. P., … YACOBI, A. (1991, August). PHARMACEUTICAL RESEARCH, Vol. 8, pp. 1071–1075.
MeSH headings : Animals; Biological Availability; Humans; Models, Biological; Permeability; Skin Absorption
Source: Web Of Science
Added: August 6, 2018
1991 journal article
Identification of the pathway of transdermal iontophoretic drug delivery: Ultrastructural studies using mercuric chloride in vivo in pigs.
Pharmaceutical Research, 8, S-141.
Source: NC State University Libraries
Added: November 23, 2022
1991 journal article
In Vivo Percutaneous Penetration/Absorption
Pharmaceutical Research, 8, 1071–1075.
Source: NC State University Libraries
Added: April 29, 2023
1991 chapter
In vitro absorption- skin flap model
In In vitro percutaneous absorption: principles, fundamentals and applications (pp. 207–222). Boca Raton, FL: CRC Press.
Source: NC State University Libraries
Added: August 6, 2018
1991 chapter
Isolated perfused skin flap and skin grafting techniques
In Dermal and ocular toxicology: fundamentals and methods (pp. 297–322). Boca Raton: CRC Press.
Source: NC State University Libraries
Added: August 6, 2018
1991 conference paper
Mustard induced vesication in isolated perfused skin: Biochemical, physiological, and morphological studies
Proceedings of the 1991 Medical Defense Bioscience Review, 159–162. Aberdeen, MD: U.S. Army Medical Research Institute of Chemical Defense.
Source: NC State University Libraries
Added: August 6, 2018
1991 conference paper
Mustard induced vesication in isolated perfused skin: biochemical physiological and morphological studies
Proceedings of the 1991 Medical Defense Bioscience Review, 28.
Event: 1991 Medical Defense Bioscience Review at Aberdeen Proving Ground, MD
Source: NC State University Libraries
Added: April 29, 2023
1991 journal article
Percutaneous Absorption of Parathion in Vitro in Porcine Skin: Effects of Dose, Temperature, Humidity, and Perfusate Composition on Absorptive Flux
Toxicological Sciences, 17(3), 494–504.
Source: Crossref
Added: January 4, 2022
1991 conference paper
Percutaneous absorption of parathion and its metabolites in a flow through diffusion cell system
The Toxicologist, 11, 289.
Event: 30th Annual Meeting of the Society of Toxicology at New Orleans, LA on February 25 - March 1, 1991
Source: NC State University Libraries
Added: October 21, 2022
1991 journal article
Perspectives on the information needs of the agricultural researcher of the 21st century
Advances in Library Administration and Organization, 9, 239–248.
Source: NC State University Libraries
Added: August 6, 2018
1991 journal article
Pharmacologic principles of residue avoidance for the practitioner
Journal of the American Veterinary Medical Association, 198, 809–816.
Source: NC State University Libraries
Added: August 6, 2018
1991 journal article
Renal clearance and fractional excretion of electrolytes over four 6-hour periods in cattle
American Journal of Veterinary Research, 52(1), 5–8.
Source: NC State University Libraries
Added: August 13, 2021
1991 conference paper
Species differences in response of kidney copper, bismuth and zinc to cisplatin among F344 rats, Wistar rats and CD-1 mice
The Toxicologist, 11, 322.
Event: 30th Annual Meeting of the Society of Toxicology at Dallas, Tx on February 25 - March 1, 1991
Source: NC State University Libraries
Added: October 21, 2022
1991 journal article
THE ISOLATED PERFUSED EQUINE SKIN FLAP - PREPARATION AND METABOLIC PARAMETERS
VETERINARY SURGERY, 20(6), 424–433.
Contributors: D. Bristol*, n, N. Monteiroriviere n, K. Bowman & R. Rogers n
MeSH headings : Abdomen; Animals; Dermatologic Surgical Procedures; Glucose / metabolism; Horses / metabolism; Horses / surgery; Lactates / metabolism; Perfusion / veterinary; Saphenous Vein / physiology; Skin / blood supply; Skin / metabolism; Surgical Flaps / veterinary
TL;DR:
Results indicate that conclusions drawn from cutaneous physiology studies should not be extrapolated across species lines and that site-specific skin should be used forcutaneous physiology, pharmacology, and toxicology studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1991 review
THE ISOLATED PERFUSED PORCINE SKIN FLAP AS AN INVITRO MODEL FOR PERCUTANEOUS-ABSORPTION AND CUTANEOUS TOXICOLOGY
[Review of ]. CRITICAL REVIEWS IN TOXICOLOGY, 21(5), 329–344.
Contributors: n & N. Monteiroriviere n
author keywords: PERCUTANEOUS ADSORPTION; INVITRO MODEL; SKIN; CUTANEOUS TOXICOLOGY; DERMATOTOXICOLOGY; DERMATOPHARMACOLOGY; ISOLATED PERFUSED PORCINE SKIN FLAP; VESICANTS; PHARMACOKINETICS; TRANSDERMAL DRUG DELIVERY; IONTOPHORESIS; CUTANEOUS METABOLISM
MeSH headings : Animals; In Vitro Techniques; Skin / pathology; Skin Absorption / drug effects; Skin Absorption / physiology; Skin Diseases / chemically induced; Skin Diseases / pathology; Skin Physiological Phenomena; Swine
TL;DR:
The isolated perfused porcine skin flap (IPPSF) is a new perfused skin model which allows in vitro cutaneous pharmacology and toxicology studies to be conducted in a viable skin preparation which has a normal anatomical structure and a functional microcirculation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1991 journal article
The use of the Food Animal Residue Avoidance Databank in reducing residues
Journal of the American Veterinary Medical Association, 198, 816–819.
Source: NC State University Libraries
Added: August 6, 2018
1991 conference paper
Transdermal iontophoresis of pyridostigmine bromide in vivo in pigs and in isolated perfused porcine skin
The Toxicologist, 11, 288.
Event: 30th Annual Meeting of the Society of Toxicology at Dallas, Tx on February 25 - March 1, 1991
Source: NC State University Libraries
Added: October 21, 2022
1990 journal article
A PHYSIOLOGICALLY RELEVANT PHARMACOKINETIC MODEL OF XENOBIOTIC PERCUTANEOUS-ABSORPTION UTILIZING THE ISOLATED PERFUSED PORCINE SKIN FLAP
JOURNAL OF PHARMACEUTICAL SCIENCES, 79(4), 305–311.
MeSH headings : Animals; Female; In Vitro Techniques; Models, Biological; Perfusion; Skin Absorption; Swine; Xenobiotics / pharmacokinetics
TL;DR:
Model parameters estimated from 8-10-h IPPSF experiments were able to predict 6-day in vivo radiolabel absorptions in pigs for topically applied benzoic acid, caffeine, malathion, parathions, DFP, testosterone, and progesterone, and compare favorably with those obtained previously using a classical compartmental modeling approach.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1990 journal article
Allometric analysis of doxycycline pharmacokinetic parameters
Journal of Veterinary Pharmacology and Therapeutics, 13(4), 404–407.
MeSH headings : Animals; Cats / metabolism; Dogs / metabolism; Doxycycline / pharmacokinetics; Goats / metabolism; Humans; Mice / metabolism; Rumen / metabolism; Sheep / metabolism; Swine / metabolism
TL;DR:
Doxycycline serum concentration-time profiles and elimination half-lives in several species were evaluated by allometric techniques and the observed difference in cats was attributed to more extensive binding to plasma proteins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018
1990 conference paper
An isolated perfused tumored skin flap model
Educational perspectives in preparation for the 21st century: Proceedings of the seventh biennial Symposium on Veterinary Pharmacology and Therapeutics, 120.
Event: 7th Biennial Symposium on Veterinary Pharmacology and Therapeutics at Raleigh, N.C. on June 12-16, 1990
Source: NC State University Libraries
Added: December 10, 2022
1990 report
Atlas of Dermal Lesions
(Office of Toxic Substances Report No. 20T-2007). Environmental Protection Agency.
Source: NC State University Libraries
Added: March 26, 2023
1990 journal article
Biological factors in absorption and penetration
Cosmetics and Toiletries, 105, 85–93.
Source: NC State University Libraries
Added: August 6, 2018
1990 journal article
Comparative pharmacokinetics of doxycycline in cats and dogs
Journal of Veterinary Pharmacology and Therapeutics, 13(4), 415–424.
MeSH headings : Animals; Cats / metabolism; Dogs / metabolism; Doxycycline / administration & dosage; Doxycycline / pharmacokinetics; Female; Half-Life; Injections, Intravenous / veterinary; Tissue Distribution
TL;DR:
The disposition of doxycycline hyclate was studied in six adult mixed-breed female cats and six adult mid-sized female dogs following a single intravenous administration of 5 mg/kg body weight.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018
1990 chapter
Cutaneous laser Doppler velocimetry in nine mammalian species
In C. Tscharner & R. E. W. Halliwell (Eds.), Advances in veterinary dermatology (p. 449). London: Balliere-Tindall.
Ed(s): C. Tscharner & R. Halliwell
Source: NC State University Libraries
Added: April 29, 2023
1990 report
Cutaneous toxicity of mustard and lewisite on the isolated perfused porcine skin flap
In DAMD17-87-C-7139; NTIS, ADA 229922 (NTIS Report No. DAMD 17-87-C-7139; pp. 1–144). NTIS.
Source: NC State University Libraries
Added: August 6, 2018
1990 conference paper
DDTC Chelation, but not MESNA, lowers cisplatin nephrotoxicity, kidney platinum levels and reduction in copper
The Toxicologist, 10, 272.
Event: 29th Annual Meeting of the Society of Toxicology at Miami Beach, FL. on February 12-16, 1990
Source: NC State University Libraries
Added: October 21, 2022
1990 article
DETERMINATION OF CARBOPLATIN IN CANINE PLASMA BY LIQUID-CHROMATOGRAPHY WITH ULTRAVIOLET VISIBLE DETECTION AND CONFIRMATION BY ATOMIC-ABSORPTION SPECTROSCOPY
TYCZKOWSKA, K., PAGE, R. L., & RIVIERE, J. E. (1990, May 18). JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, Vol. 527, pp. 447–453.
MeSH headings : Animals; Antineoplastic Agents / blood; Carboplatin; Chromatography, High Pressure Liquid / methods; Dogs; Molecular Structure; Organoplatinum Compounds / blood; Protein Binding; Spectrophotometry, Atomic
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1990 conference paper
Development of an isolated perfused equine skin flap and assessment of flap metabolism
Scientific Presentation Abstracts: American College of Veterinary Surgeons 25th Annual Meeting, 19(1), 59–60.
Event: American College of Veterinary Surgeons 25th Annual Meeting at New Orleans, LA
Source: NC State University Libraries
Added: December 10, 2022
1990 conference paper
Differential tissue distribution of cisplatin (CDDP) in dogs resulting from the use of defined intravenous input profiles
The Toxicologist, 10, 241.
Event: 29th Annual Meeting of the Society of Toxicology at Miami Beach, FL. on February 12-16, 1990
Source: NC State University Libraries
Added: October 21, 2022
1990 journal article
EFFECT OF HYPERTHERMIA ON CISPLATIN (CDDP) DISPOSITION TO ISOLATED PERFUSED SKIN
INTERNATIONAL JOURNAL OF HYPERTHERMIA, 6(5), 923–932.
MeSH headings : Animals; Biological Transport, Active; Hot Temperature; In Vitro Techniques; Models, Biological; Organoplatinum Compounds / pharmacokinetics; Perfusion; Skin / metabolism; Swine
TL;DR:
It is suggested that heat does not increase tissue uptake ofCDDP after infusion in isolated perfused skin, although it does increase the mobility of CDDP as evidenced by shorter transit times through the IPPSF.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1990 journal article
INTERSPECIES AND INTERREGIONAL ANALYSIS OF THE COMPARATIVE HISTOLOGIC THICKNESS AND LASER DOPPLER BLOOD-FLOW MEASUREMENTS AT 5 CUTANEOUS SITES IN 9 SPECIES
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 95(5), 582–586.
Contributors: N. Monteiroriviere n, D. Bristol n, T. Manning n, R. Rogers n & n
MeSH headings : Animals; Blood Flow Velocity / physiology; Cats; Cattle; Dogs; Horses; Macaca mulatta; Mice; Mice, Inbred Strains; Rabbits; Rats; Rats, Inbred Strains; Skin / cytology; Skin / diagnostic imaging; Skin Physiological Phenomena; Species Specificity; Swine; Ultrasonics; Ultrasonography
TL;DR:
The data indicate that thickness and LDV blood flow are independent and must be evaluated separately when comparisons are made between species and body sites, and provides a data base for future comparative studies in which a knowledge of skin thickness or blood flow might be important variables.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1990 conference paper
In vitro techniques for assessing percutaneous pesticide absorption
Proceedings Society of Environmental Toxicology and Chemistry, 50.
Event: 11th Annual Meeting of the Society of Environmental Toxicology and Chemistry at Washington, D.C. on November 11-15, 1990
Source: NC State University Libraries
Added: December 10, 2022
1990 journal article
Isolated perfused porcine skin flap model
European Journal of Pharmacology, 183(1), 129.
Source: NC State University Libraries
Added: December 10, 2022
1990 journal article
Isolated perfused tumored skin flap model
Veterinary Cancer Society Newsletter, 14, 1–6.
Source: NC State University Libraries
Added: August 6, 2018
1990 journal article
Nonuniform alteration of cis-diamminedichloroplatinum (II) tissue distribution in dogs with whole body hyperthermia
Cancer Research, 50(7), 2075–2080.
Source: NC State University Libraries
Added: August 6, 2018
1990 article
PROCEEDINGS OF THE WORKSHOP ON THE ACCEPTABILITY AND INTERPRETATION OF DERMAL DEVELOPMENTAL TOXICITY STUDIES
KIMMEL, C. A., & FRANCIS, E. Z. (1990, February). FUNDAMENTAL AND APPLIED TOXICOLOGY, Vol. 14, pp. 386–398.
MeSH headings : Absorption; Administration, Cutaneous; Animals; Female; Humans; Irritants; Pregnancy; Research Design; Risk Factors; Teratogens / administration & dosage; Teratogens / pharmacokinetics; Teratogens / toxicity
TL;DR:
It is concluded that dermal developmental toxicity studies without any indication of maternal or developmental toxicity are inadequate for risk assessment unless accompanied by absorption data, and absorption data and limited pharmacokinetic data should be collected in every der mal developmental toxicity study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1990 journal article
Parathion metabolism during percutaneous absorption in perfused porcine skin
Pesticide Biochemistry and Physiology, 38(3), 245–254.
TL;DR:
It is shown that parathion undergoes significant biotransformation following topical application to porcine skin and that the resultant cutaneous metabolite profiles can be altered by both physical (occlusion) and chemical (ABT) means.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018
1990 conference paper
Peptide isoelectric focussing as a necessary prerequisite to their transdermal iontophoretic delivery
Educational perspectives in preparation for the 21st century: Proceedings of the seventh biennial Symposium on Veterinary Pharmacology and Therapeutics, 121.
Event: 7th Biennial Symposium on Veterinary Pharmacology and Therapeutics at Raleigh, N.C. on June 12-16, 1990
Source: NC State University Libraries
Added: December 10, 2022
1990 conference paper
Peptide isoelectric focussing as a necessary prerequisite to their transdermal iontophoretic delivery
Educational perspectives in preparation for the 21st century: Proceedings of the seventh biennial Symposium on Veterinary Pharmacology and Therapeutics, 121.
Event: 7th Biennial Symposium on Veterinary Pharmacology and Therapeutics at Raleigh, N.C. on June 12-16, 1990
Source: NC State University Libraries
Added: December 10, 2022
1990 chapter
Percutaneous absorption of pesticides in the isolated perfused porcine skin flap (IPPSF)
In R. E. W. Halliwell & C. Tscharner (Eds.), Advances in veterinary dermatology. Vol. 1 (pp. 299–307). London: Balliere-Tindall.
Ed(s): R. Halliwell & C. Tscharner
Source: NC State University Libraries
Added: August 6, 2018
1990 conference paper
Percutaneous absorption of radiolabeled organophosphates, carbaryl and lindane in the isolated perfused porcine skin flap
The Toxicologist, 10, 257.
Event: 29th Annual Meeting of the Society of Toxicology at Miami Beach, FL.
Source: NC State University Libraries
Added: October 21, 2022
1990 journal article
Pharmacokinetics and metabolic inertness of doxycycline in young pigs.
American Journal of Veterinary Research, 51, 1271–1275.
Source: NC State University Libraries
Added: November 23, 2022
1990 journal article
Pharmacokinetics, inhibition of lymphoblast transformation and subacute oral toxicity of cyclosporine in swine
American Journal of Veterinary Research, 51, 399–403.
Source: NC State University Libraries
Added: August 6, 2018
1990 conference paper
Predicting the dermal penetration and absorption of topically applied chemicals
Proceedings of the Conference on Agricultural Chemical Utilization and Human Health. Presented at the Conference on Agricultural Chemical Utilization and Human Health.
Event: Conference on Agricultural Chemical Utilization and Human Health
Source: NC State University Libraries
Added: April 29, 2023
1990 conference paper
Quantitative prediction of percutaneous absorption using isolated perfused skin
Proceedings of the 5th Annual Meeting of the American Association of Pharmaceutical Science, 162.
Event: 5th Annual Meeting of the American Association of Pharmaceutical Science
Source: NC State University Libraries
Added: April 29, 2023
1990 conference paper
Septic arthritis: use of therapeutic monitoring to optimize antibiotic therapy
Proceedings of the Annual Convention of the American Association of Equine Practitioners, 36, 125–131.
Source: NC State University Libraries
Added: August 6, 2018
1990 conference paper
The effect of environmental factors on the percutaneous absorption and cutaneous metabolism of parathion
Educational perspectives in preparation for the 21st century: Proceedings of the seventh biennial Symposium on Veterinary Pharmacology and Therapeutics, 121.
Event: 7th Biennial Symposium on Veterinary Pharmacology and Therapeutics at Raleigh, N.C. on June 12-16, 1990
Source: NC State University Libraries
Added: December 10, 2022
1990 conference paper
The effect of whole body hyperthermia on pharmacokinetics and toxicity of doxorubicin and lonidamine in normal dogs
Proceedings of the Radiation Research Society, 38, 27.
Source: NC State University Libraries
Added: April 29, 2023
1990 conference paper
The isolated perfused porcine skin flap (IPPSF). A new model for the study of percutaneous absorption and cutaneous toxicity
Proceedings the 2nd International Symposium on Pig Model for Biomedical Research. Presented at the 2nd International Symposium on Pig Model for Biomedical Research, Center of Academic Activities, Academia Sinica, Taipei, Taiwan, Republic of China.
Event: 2nd International Symposium on Pig Model for Biomedical Research at Center of Academic Activities, Academia Sinica, Taipei, Taiwan, Republic of China on November 29 - December 2, 1990
Source: NC State University Libraries
Added: April 29, 2023
1990 conference paper
The isolated perfused skin flap: Interspecies and intersite differences in metabolism
Abstracts of papers presented at the 71st Annual Meeting of the Conference of Research Workers in Animal Disease, 23.
Event: 71st Conference of Research Workers in Animal Diseases at Chicago, IL on November 5-6, 1990
Source: NC State University Libraries
Added: December 10, 2022
1990 conference paper
The role of FARAD in food contamination mitigation and prevention
Veterinary Pharmacology, Toxicology and Therapy in Food Producing Animals. Proceed. 4th Congress European Assoc. Vet. Pharmacol. Toxicol., 4, 255–258.
Source: NC State University Libraries
Added: August 6, 2018
1990 conference paper
Transdermal penetration and metabolism of organophosphate insecticides
Proceedings of the American Chemical Society, 199.
Source: NC State University Libraries
Added: April 29, 2023
1989 chapter
Cephalosporins
In Current veterinary therapy X (Vol. 10, pp. 74–77). Philadelphia: WB Saunders Co.
Source: NC State University Libraries
Added: August 6, 2018
1989 book
Comprehensive Compendium of Food Animal Drugs: The Food Animal Residue Avoidance Databank Tradename File
(3rd ed.). Gainesville: University of Florida Press.
Source: NC State University Libraries
Added: April 29, 2023
1989 journal article
Concerned about intravenous use of doxycycline in horses
Journal of the American Veterinary Medical Association, 195, 846–848.
Source: NC State University Libraries
Added: May 6, 2023
1989 journal article
DEFINITION OF A PHYSIOLOGIC PHARMACOKINETIC MODEL OF CUTANEOUS DRUG DISTRIBUTION USING THE ISOLATED PERFUSED PORCINE SKIN FLAP
JOURNAL OF PHARMACEUTICAL SCIENCES, 78(7), 550–555.
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Carboplatin; Cisplatin / administration & dosage; Cisplatin / pharmacokinetics; Doxycycline / administration & dosage; Doxycycline / pharmacokinetics; In Vitro Techniques; Models, Biological; Organoplatinum Compounds / administration & dosage; Organoplatinum Compounds / pharmacokinetics; Perfusion; Pharmaceutical Preparations / metabolism; Pharmacokinetics; Skin / metabolism; Swine; Tetracycline / administration & dosage; Tetracycline / pharmacokinetics
TL;DR:
A physiologic pharmacokinetic model describing drug disposition in the isolated perfused porcine skin flap (IPPSF) is derived and experimental infusion applications of the cancer chemotherapeutic agents cisplatin and carboplatin and the antimicrobials tetracycline and doxycycline are reported herein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1989 journal article
DETERMINATION OF DOXYCYCLINE IN BOVINE-TISSUES AND BODY-FLUIDS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY USING PHOTODIODE ARRAY ULTRAVIOLET-VISIBLE DETECTION
JOURNAL OF PHARMACEUTICAL SCIENCES, 78(1), 44–47.
MeSH headings : Animals; Cattle; Chromatography, High Pressure Liquid; Doxycycline / analysis; Doxycycline / blood; Doxycycline / urine; Indicators and Reagents; Kidney Medulla / analysis; Liver / analysis; Muscles / analysis; Spectrophotometry, Ultraviolet
TL;DR:
A sensitive and selective high-performance liquid chromatographic assay was developed to quantitate doxycycline concentrations in bovine tissues and body fluids to extract tissue-bound drug.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1989 journal article
DOXYCYCLINE BINDING TO PLASMA-ALBUMIN OF SEVERAL SPECIES
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 12(3), 253–260.
MeSH headings : Animals; Cats / blood; Cattle / blood; Dogs / blood; Doxycycline / metabolism; Humans; Protein Binding; Regression Analysis; Serum Albumin / metabolism; Sheep / blood; Software; Swine / blood
TL;DR:
The affinity of doxycycline for crystalline plasma albumin fraction V, originating from sheep, dogs, cats, cows, pigs and humans, was evaluated by means of double-reciprocal and Scatchard plots and suggested slight species-related differences in the values of association constants.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1989 conference paper
Effect of temperature on cisplatin (CDDP) and carboplatin (CBDCA) pharmacokinetic disposition in dogs
Conference Proceedings, 2, 499–501.
Source: NC State University Libraries
Added: August 6, 2018
1989 conference paper
Effects of copper or bismuth preloading or DDTC rescue on cisplatin nephrotoxicity and kidney metal concentrations
The Toxicologist, 9, 175.
Event: 28th Annual Meeting of the Society of Toxicology at Atlanta, GA on February 27 - March 3, 1989
Source: NC State University Libraries
Added: October 21, 2022
1989 journal article
Effects of tetracyclines on the kidney in cattle and dogs
Journal of the American Veterinary Medical Association, 195, 995–997.
Source: NC State University Libraries
Added: August 6, 2018
1989 conference paper
Effects of whole body hyperthermia on the tissue disposition of cisplatin in dogs
Proceedings of the Radiation Research Society, 37, 35.
Source: NC State University Libraries
Added: April 29, 2023
1989 journal article
Estimation of physiological volumes in the isolated perfused porcine skin flap
Research Communications in Chemical Pathology and Pharmacology, 66, 145–158.
Source: NC State University Libraries
Added: August 6, 2018
1989 journal article
Fatalities associated with intravenous administration of a single subtherapeutic dose of doxycycline to horses
Journal of the American Veterinary Medical Association, 195, 846–848.
Source: NC State University Libraries
Added: August 6, 2018
1989 conference paper
Optimization of iontophoretic flux of lidocaine using the isolated perfused porcine skin flap
Controlled Release Society.
Source: NC State University Libraries
Added: April 29, 2023
1989 journal article
PERCUTANEOUS-ABSORPTION AND EXCRETION OF XENOBIOTICS AFTER TOPICAL AND INTRAVENOUS ADMINISTRATION TO PIGS
FUNDAMENTAL AND APPLIED TOXICOLOGY, 13(4), 714–722.
MeSH headings : Administration, Topical; Animals; Feces / analysis; Female; In Vitro Techniques; Injections, Intravenous; Skin Absorption; Swine; Xenobiotics / administration & dosage; Xenobiotics / pharmacokinetics
TL;DR:
Calculations based on urinary excretion alone underestimated percutaneous absorption determined from total excretion by 5-30%, although the difference between the two estimates was statistically significant only for C (p less than 0.05).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1989 conference paper
Percutaneous absorption of pesticides in the isolated perfused porcine skin flap (IPPSF
Proceedings of the World Congress of Veterinary Dermatology, 68.
Source: NC State University Libraries
Added: April 29, 2023
1989 journal article
Pharmacokinetics and metabolic inertness of doxycycline in calves with mature or immature rumen function
American Journal of Veterinary Research, 50, 1329–1333.
Source: NC State University Libraries
Added: August 6, 2018
1989 journal article
Pharmacokinetics and toxicity of intravenous lonidamine and whole body hyperthermia in normal dogs
Proceedings of the Radiation Research Society, 37, 69.
Source: NC State University Libraries
Added: April 29, 2023
1989 journal article
Pharmacologic principles of residue avoidance for the practitioner
Journal of the American Veterinary Medical Association, 194, 1776.
Source: NC State University Libraries
Added: December 10, 2022
1989 conference paper
Phase I evaluation of carboplatin at 37 and 42C in tumor bearing dogs
Proceedings of the Radiation Research Society, 37, 35.
Source: NC State University Libraries
Added: April 29, 2023
1989 conference paper
Production of 1,25 dihydroxyvitamine D by pig skin in situ
Journal of Investigative Dermatology, 92(3), 404.
Event: European Society for Dermatological Research (ESDR), the Japanese Society for Investigative Dermatology (JSID), and the Society for Investigative Dermatology (SID) Tricontinental Meeting at Washington, D.C. on April 26-30, 1989
Source: NC State University Libraries
Added: December 10, 2022
1989 journal article
Production of 1,25 dihydroxyvitamine D by pig skin in situ
Clinical Research, 37, A708.
Source: NC State University Libraries
Added: April 29, 2023
1989 conference paper
Quantitative prediction of in vivo percutaneous absorption profiles using in vitro perfused porcine skin
The Toxicologist, 9, 60.
Event: 28th Annual Meeting of the Society of Toxicology at Atlanta, GA on February 27 - March 3, 1989
Source: NC State University Libraries
Added: October 21, 2022
1989 journal article
THE ISOLATED PERFUSED PORCINE SKIN FLAP .3. PERCUTANEOUS-ABSORPTION PHARMACOKINETICS OF ORGANOPHOSPHATES, STEROIDS, BENZOIC-ACID, AND CAFFEINE
TOXICOLOGY AND APPLIED PHARMACOLOGY, 97(2), 324–337.
MeSH headings : Animals; Benzoates / pharmacokinetics; Benzoic Acid; Caffeine / pharmacokinetics; In Vitro Techniques; Insecticides / pharmacokinetics; Models, Biological; Organophosphorus Compounds; Skin Absorption; Steroids / pharmacokinetics; Surgical Flaps; Swine
TL;DR:
The results suggest that xenobiotic penetration in the 8-hr IPPSF experiments is highly predictive of in vivo absorption totals (6-day studies), and since pig and human skin are similar physiologically and pharmacologically, theIPPSF may eventually have applications in formulating human dermal risk assessment models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1989 article
TRANSDERMAL LIDOCAINE IONTOPHORESIS IN ISOLATED PERFUSED PORCINE SKIN
JOURNAL OF TOXICOLOGY-CUTANEOUS AND OCULAR TOXICOLOGY, Vol. 8, pp. 493–504.
TL;DR:
The isolated perfused porcine skin flap is an alternative animal model for quantitatively assessing percutaneous drug absorption and the dynamics of transdermal delivery using iontophoresis are investigated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1989 journal article
The Food Animal Residue Avoidance Databank: An information support program for responsible drug use
Journal of the American Veterinary Medical Association, 194, 1776.
Source: NC State University Libraries
Added: December 10, 2022
1989 conference paper
The isolated perfused porcine skin flap model for predicting skin permeation
Proceedings of the 4th Annual Meeting Symposium, American Association of Pharmaceutical Science, A83.
Source: NC State University Libraries
Added: April 29, 2023
1989 conference paper
Tissue disposition of cisplatin (CDDP) in normothermic and hyperthermic dogs
Toxicologist, 9, 175.
Event: 28th Annual Meeting of the Society of Toxicology at Atlanta, GA on February 27 - March 3, 1989
Source: NC State University Libraries
Added: October 21, 2022
1988 conference paper
A pharmacokinetic model describing xenobiotic percutaneous absorption in the isolated perfused porcine skin flap
Second Symposium on Frontiers of Pharmacokinetics and Pharmacodynamics.
Source: NC State University Libraries
Added: May 6, 2023
1988 journal article
Aflatoxin-Impaired Ability to Accumulate Oxycarotenoid Pigments During Restoration in Young Chickens
Poultry Science, 67(4), 619–625.
MeSH headings : Aflatoxins / pharmacology; Animals; Carotenoids / metabolism; Chickens / metabolism; Male; Pigmentation Disorders / chemically induced; Pigmentation Disorders / metabolism; Pigmentation Disorders / veterinary; Poultry Diseases / chemically induced; Poultry Diseases / metabolism; Skin Pigmentation / drug effects
TL;DR:
The mechanism by which aflatoxin causes paling in chickens was investigated by measuring its effect on the restoration of pigments in 3-wk-old birds made pale by feeding a white corn-soy diet, which implied that the normal accumulation of lutein from the diet proceeded into and through the mucosa to the serum to depot sites in the liver and integument.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(OpenAlex)
Sources: Crossref, Web Of Science
Added: August 6, 2018
1988 conference paper
Binding of doxycycline to plasma albumin of several species
Proceedings of the 6th Biennial Symposium of the American Academy of Veterinary Pharmacology and Therapeutics, 121, 50.
Source: NC State University Libraries
Added: May 6, 2023
1988 book
Comprehensive Compendium of Food Animal Drugs: The Food Animal Residue Avoidance Databank Tradename File
(2nd ed.). Gainesville: University of Florida Press.
Source: NC State University Libraries
Added: April 29, 2023
1988 conference paper
Coping with the information explosion in pharmacology: The food animal residue avoidance databank
Proceedings of the 6th Biennial Symposium of the American Academy of Veterinary Pharmacology and Therapeutics, 6, 82–85.
Source: NC State University Libraries
Added: August 6, 2018
1988 conference paper
Development of an in vitro perfused skin flap model for transdermal drug delivery studies
Workshop on Transdermal Delivery of Drugs.
Source: NC State University Libraries
Added: August 6, 2018
1988 conference paper
Development of automated clinical pharmacokinetic dosing programs for therapeutic drug monitoring in veterinary medicine
Proc. Sixth Biennial Symp. Am. Acad. Vet. Pharmacol. Therap., 6, 86–89.
Source: NC State University Libraries
Added: August 6, 2018
1988 conference paper
Development of perfused skin models for assessing percutaneous absorption
Burroughs Wellcome Symposium on Dermal Toxicology, 28–40.
Source: NC State University Libraries
Added: August 6, 2018
1988 conference paper
Doxycycline binding to bovine albumin: No displacing effect of diphenylhydantoin, phenobarbital or carbamazepine
4th Congress European Association of Veterinary Pharmacology and Toxicology, I, 40.
Source: NC State University Libraries
Added: May 6, 2023
1988 journal article
Gentamicin pharmacokinetics and nephrotoxicity in naturally acquired and experimentally induced disease in dogs
Journal of the American Veterinary Medical Association, 192, 57–63.
Source: NC State University Libraries
Added: August 6, 2018
1988 journal article
Influence of decreased renal mass on nephrotoxicity: Ultrastructural morphometric and functional studies
The Toxicologist, 8, 134.
Event: 27th Annual Meeting of the Society of Toxicology at Dallas, Tx on February 15-19, 1988
Source: NC State University Libraries
Added: October 21, 2022
1988 conference paper
Integration of pharmacology research and graduate training
Proc. Sixth Biennial Symp. Am. Acad. Vet. Pharmacol. Therap., 66–69.
Source: NC State University Libraries
Added: August 6, 2018
1988 conference paper
Interaction of regional hyperthermia with antineoplastic drug delivery pharmacokinetics. Studies in an isolated perfused skin flap system
Proceedings of the Radiation Research Society, 36, 16.
Source: NC State University Libraries
Added: April 29, 2023
1988 article
MULTIPLE INTRAVENOUS DOSE PHARMACOKINETICS AND RESIDUE DEPLETION PROFILE OF GENTAMICIN IN PIGS
RIOND, J. L., & RIVIERE, J. E. (1988, June). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 11, pp. 210–214.
MeSH headings : Animals; Blood Urea Nitrogen; Creatinine / blood; Drug Residues / metabolism; Female; Gentamicins / administration & dosage; Gentamicins / pharmacokinetics; Injections, Intravenous / veterinary; Swine / metabolism; Time Factors; Tissue Distribution
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1988 journal article
PHARMACOKINETIC ESTIMATION FOR THERAPEUTIC DOSAGE REGIMENS (PETDR) - A SOFTWARE PROGRAM DESIGNED TO DETERMINE INTRAVENOUS DRUG-DOSAGE REGIMENS FOR VETERINARY APPLICATIONS
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 11(4), 390–396.
MeSH headings : Animals; Injections, Intravenous; Pharmaceutical Preparations / administration & dosage; Pharmacokinetics; Software; Veterinary Medicine / methods
TL;DR:
PETDR is a soft-ware program used to design individualized intravenous dosage regimens, determine concentration-time profiles, predict serum concentrations at a specific time after intravenous dosing and predict the time after the last dose to achieve a specified concentration of drug.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1988 conference paper
Pharmacokinetics, pharmacodynamics and subacute oral toxicity of cyclosporine-A, (CyA) in pigs
Proceedings of the 6th Biennial Symposium of the American Academy of Veterinary Pharmacology and Therapeutics, 121.
Source: NC State University Libraries
Added: May 6, 2023
1988 journal article
Pharmacology and toxicology of doxycycline
Veterinary and Human Toxicology, 30, 431–443.
Source: NC State University Libraries
Added: August 6, 2018
1988 journal article
Phase I and pharmacokinetic study of lonidamine in normal dogs
Proceedings of the Radiation Research Society, 36, 38.
Source: NC State University Libraries
Added: April 29, 2023
1988 conference paper
Significant first-pass bioactivation of parathion (P) during percutaneous absorption in the isolated perfused porcine skin flap (IPPSF
The Toxicologist, 8, 125.
Event: 27th Annual Meeting of the Society of Toxicology at Dallas, Tx on February 15-19, 1988
Source: NC State University Libraries
Added: October 21, 2022
1988 conference paper
The role of the food animal residue avoidance databank (FARAD) in food contamination mitigation and prevention
4th Congress European Association Veterinary Pharmacology and Toxicology, I, 157.
Source: NC State University Libraries
Added: May 6, 2023
1988 journal article
Veterinary Clinical Pharmacokinetics. Part I Fundamental Concepts
Compendium of Continuing Education for the Practicing Veterinarian, 10, 24–31.
Source: NC State University Libraries
Added: August 6, 2018
1988 journal article
Veterinary clinical pharmacokinetics. Part II. Modeling
Compendium on Continuing Education for the Practicing Veterinarian, 10, 313–328.
Source: NC State University Libraries
Added: August 6, 2018
1987 chapter
Basic principles of antibiotic use
In D. Johnston (Ed.), Bristol Veterinary Handbook of Antimicrobial Therapy (2nd ed., pp. 9–16). Princeton Junction, NJ: Veterinary Learning Systems, Inc.
Ed(s): D. Johnston
Source: NC State University Libraries
Added: August 6, 2018
1987 report
Development of in vitro isolated perfused porcine skin flaps for study of percutaneous absorption of xenobiotics
In DAMD17-84-C-4103, NTIS, ADA 204615 (pp. 1–126).
TL;DR:
The research resulted in a reproducible perfusion model optimized for the xenobiotic absorption studies to be conducted in the second year, which would be an humane alternative animal model for studies in cutaneous toxicology, physiology, oncology, and percutaneous drug absorption and metabolism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: August 6, 2018
1987 journal article
Dose-response studies of gentamicin nephrotoxicity in rats with experimental renal dysfunction. III. Effects of dosage reduction method.
Research Communications in Chemical Pathology and Pharmacology, 57, 301–311.
Source: NC State University Libraries
Added: August 6, 2018
1987 chapter
Drug use in presence of liver and kidney disease
In Bristol veterinary handbook of antimicrobial therapy (2nd) (pp. 274–276). Princeton Junction, NJ: Veterinary Learning Systems Inc.
Source: NC State University Libraries
Added: August 6, 2018
1987 conference paper
Effect of dopamine on renal function and platinum excretion during whole body hyperthermia in dogs
Proceedings of the 8th International Congress of Radiation Research. Presented at the 8th International Congress of Radiation Research, Edinburgh, Scotland.
Event: 8th International Congress of Radiation Research at Edinburgh, Scotland
Source: NC State University Libraries
Added: May 6, 2023
1987 book
Food Animal Residue Avoidance Databank Trade Name File: Comprehensive Compendium of Food Animal Drugs
Gainesville, FL.: University of Florida Press.
Source: NC State University Libraries
Added: December 10, 2022
1987 journal article
GENTAMICIN DOSING STRATEGIES FOR DOGS WITH SUBCLINICAL RENAL DYSFUNCTION
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 31(12), 1929–1934.
MeSH headings : Animals; Dogs; Gentamicins / administration & dosage; Gentamicins / pharmacokinetics; Kidney Diseases / complications; Kidney Diseases / physiopathology; Nephrectomy
TL;DR:
Predicted 30-min postdosing concentrations in serum were lowest in dogs administered drug TID, and gentamicin clearance decreased in this group with treatment, suggesting that this regimen may be the least efficacious as well as the most prone to causing future nephrotoxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1987 book
L'usage de la gentamicine en medicine veterinaire
In Schweizer Archiv Fur Tierheilkunde (Vol. 129, pp. 565–583).
Source: NC State University Libraries
Added: August 6, 2018
1987 personal communication
ON THE DEFINITION OF VIABILITY IN ISOLATED PERFUSED SKIN PREPARATIONS
RIVIERE, J. E., BOWMAN, K. F., & MONTEIRORIVIERE, N. A. (1987, May).
Contributors: n, K. Bowman n & N. Monteiroriviere n
MeSH headings : Animals; Humans; In Vitro Techniques; Perfusion; Skin / metabolism; Surgical Flaps
TL;DR:
No evidence was obtained that oral indomethacin administration influences the response of psoriasis to dithranol treatment one way or the other, but there was a trend towards the indometHacin group faring better, in that the final concentration of dithrano! reached was lower, the speed of movement between concentrations was more rapid and the time to clearance was less that that in the placebo group.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1987 journal article
PHARMACOKINETICS AND TOXICITY OF INTRAPERITONEAL CISPLATIN COMBINED WITH REGIONAL HYPERTHERMIA
JOURNAL OF CLINICAL ONCOLOGY, 5(10), 1613–1620.
MeSH headings : Animals; Cisplatin / blood; Cisplatin / pharmacokinetics; Cisplatin / toxicity; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Female; Hepatitis, Animal / etiology; Hyperthermia, Induced / adverse effects; Injections, Intraperitoneal; Lymph Nodes / pathology; Male; Ovarian Neoplasms; Peritonitis / etiology; Pulmonary Fibrosis / etiology; Temperature; Tissue Distribution
TL;DR:
The hypothesis that, with IP temperature elevation, there is an increased rate of generation and retention of reactive metabolites of cisplatin in the peritoneal cavity relative to unheated controls is supported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1987 conference paper
Percutaneous absorption kinetics of organophosphates, steroids, caffeine and benzoic acid in the isolated perfused porcine skin flap (IPPSF)
The Toxicologist, 7, 244.
Event: 26th Annual Meeting of The Society of Toxicology at Washington, D.C. on February 24-27, 1987
Source: NC State University Libraries
Added: October 21, 2022
1987 conference paper
Percutaneous absorption of organophosphates, steroids, caffeine and benzoic acid in vivo and in vitro using the isolated perfused porcine skin flap (IPPSF)
Proceedings of the 6th Medical Chemical Defense Bioscience Review, 763–766. Aberdeen, MD: Aberdeen Proving Ground.
Source: NC State University Libraries
Added: August 6, 2018
1987 conference paper
Studies on the in vitro isolated perfused porcine skin flap for physiological modeling in surgical research
Scientific Presentation Abstracts: American College of Veterinary Surgeons 22nd Annual Meeting, 16(1), 84.
Event: American College of Veterinary Surgeons 22nd Annual Meeting
Source: NC State University Libraries
Added: December 10, 2022
1987 chapter
The aminoglycosides
In Bristol veterinary handbook of antimicrobial therapy (2nd) (pp. 257–260). Princeton Junction, NJ: Veterinary Learning Systems Inc.
Source: NC State University Libraries
Added: August 6, 2018
1987 journal article
The isolated perfused porcine skin flap
Humane Innovations and Alternatives in Animal Experimentation, 1, 7.
Source: NC State University Libraries
Added: August 6, 2018
1987 chapter
The isolated perfused porcine skin flap
In E. M. Bernstein (Ed.), Humane Innovations and Alternatives in Animal Experimentation: A Notebook. (p. 7). Saranac Lake, NY: Psychologists for the Ethical Treatment of Animals.
Ed(s): E. Bernstein
Source: NC State University Libraries
Added: December 10, 2022
1987 journal article
The isolated perfused porcine skin flap (IPPSF). II. Ultrastructural and histological characterization of epidermal viability
In Vitro Toxicology, 1, 241–252.
Source: NC State University Libraries
Added: August 6, 2018
1987 journal article
The national food animal residue avoidance databank
Microecology and Therapy, 17, 135.
Source: NC State University Libraries
Added: December 10, 2022
1987 journal article
The use of controlled drug infusions in toxicokinetic studies
Journal of the American Veterinary Medical Association, 190, 1621.
Source: NC State University Libraries
Added: December 10, 2022
1987 chapter
Toxicity and interactions
In D. Johnston (Ed.), Bristol Veterinary Handbook of Antimicrobial Therapy (2nd ed., pp. 277–284). Princeton Junction, NJ: Veterinary Learning Systems, Inc.
Ed(s): D. Johnston
Source: NC State University Libraries
Added: August 6, 2018
1986 conference paper
A novel model for cutaneous toxicologic research: The isolated perfused porcine skin flap (IPPSF)
The Toxicologist, 6, 242.
Event: 25th Meeting of the Society of Toxicology at New Orleans, LA
Source: NC State University Libraries
Added: October 21, 2022
1986 chapter
Adverse drug reactions
In Current veterinary therapy IX: small animal practice (Vol. 9, pp. 169–176). Philadelphia: WB Saunders Co.
Source: NC State University Libraries
Added: August 6, 2018
1986 chapter
Antibiotic therapy
In Manual of small animal surgical therapeutics (pp. 35–44). New York: Churchill Livingstone, Inc.
Source: NC State University Libraries
Added: August 6, 2018
1986 conference paper
Cisplatin (CDDP) pharmacokinetics at 37C and 42C in the dog
Proceedings of the Radiation Research Society, 34, 16.
Source: NC State University Libraries
Added: April 29, 2023
1986 journal article
Computerized Food Animal Residue Avoidance Databank for veterinarians
Journal of the American Veterinary Medical Association, 183, 73–76.
Source: NC State University Libraries
Added: August 6, 2018
1986 report
Development of in vitro isolated perfused porcine skin flaps for study of percutaneous absorption of xenobiotics
In DAMD17-84-C-4103, NTIS, ADA 198960 (pp. 1–23).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1986 report
Development of in vitro isolated perfused porcine skin flaps for study of percutaneous absorption of xenobiotics
(NTIS Report No. DAMD17-84C-4103).
Source: NC State University Libraries
Added: April 29, 2023
1986 journal article
Dose dependent pharmacokinetics of gentamicin in sheep
American Journal of Veterinary Research, 47, 789–794.
Source: NC State University Libraries
Added: August 6, 2018
1986 journal article
EXPONENTIAL INTRAVENOUS INFUSIONS IN TOXICOLOGICAL STUDIES - ACHIEVING IDENTICAL SERUM DRUG CONCENTRATION PROFILES IN INDIVIDUALS WITH ALTERED PHARMACOKINETIC STATES
JOURNAL OF PHARMACEUTICAL SCIENCES, 75(5), 448–451.
MeSH headings : Animals; Dogs; Drug-Related Side Effects and Adverse Reactions; Female; Gentamicins / administration & dosage; Gentamicins / adverse effects; Gentamicins / blood; Infusions, Parenteral; Kinetics; Nephrectomy; Pharmaceutical Preparations / administration & dosage; Pharmaceutical Preparations / blood
TL;DR:
In this paper, model-independent deconvolution analysis is applied to derive the infusion schedule needed to achieve a constant serum concentration followed by a predetermined monoexponential decline in concentration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1986 journal article
Effect of dose and duration of therapy on gentamicin tissue residues in sheep
American Journal of Veterinary Research, 47, 2373–2379.
Source: NC State University Libraries
Added: August 6, 2018
1986 journal article
Effect of hyperthermia on cisplatin pharmacokinetics in normal dogs
International Journal of Hyperthermia, 2, 351–358.
MeSH headings : Animals; Biotransformation; Cisplatin / blood; Cisplatin / metabolism; Dogs; Half-Life; Hyperthermia, Induced / methods; Kinetics; Platinum / blood; Spectrophotometry, Atomic; Ultrafiltration
TL;DR:
Data from in vitro and in vivo cisplatin pharmacokinetic studies in dogs would indicate that at the elevated temperatures encountered in whole body hyperthermia, the rate of formation of reactive metabolites from parent cisPlatin is increased.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
1986 conference paper
Effects of disease on drug binding to serum proteins
Comparative veterinary pharmacology, toxicology, and therapy: proceedings of the 3rd Congress of the European Association for Veterinary Pharmacology and Toxicology, August 25-29, 1985, Ghent, Belgium, 3, 407–414.
TL;DR:
The preliminary investigations showed that, as in humans, the binding of organic bases is increased in diseases associated with stress and inflammation, and that larger doses of basic drugs may be required if the patient has a concurrent disease associated with inflammation.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
1986 journal article
Exaggerated response to gentamicin induced nephrotoxicity in Sprague Dawley rats: Identification of a highly sensitive outlier population
Toxicologic Pathology, 14, 204–209.
MeSH headings : Animals; Blood Urea Nitrogen; Creatinine / blood; Gentamicins / blood; Gentamicins / toxicity; Kidney Diseases / chemically induced; Kidney Tubules / pathology; Kinetics; Male; Necrosis; Rats; Rats, Inbred Strains; Risk
TL;DR:
Post-treatment creatinine and urea nitrogen were not normally distributed in the entire study population, however, when the population was divided into normal and sensitive subgroups, both subgroup values were normally distributed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
1986 conference paper
Exponential intravenous infusions in toxicological studies. Achieving identical serum drug concentration profiles in individuals with altered pharmacokinetic states
The Toxicologist, 6, 305.
Event: 25th Meeting of the Society of Toxicology at New Orleans, LA on March 3-7, 1986
Source: NC State University Libraries
Added: October 28, 2022
1986 review
FOOD ANIMAL RESIDUE AVOIDANCE DATA-BANK (FARAD) - A PHARMACOKINETIC-BASED INFORMATION RESOURCE
[Review of ]. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 9(3), 237–245.
MeSH headings : Anti-Bacterial Agents; Food Contamination; Government Agencies; Information Systems; Meat; Mycotoxins; Pesticides; United States
TL;DR:
The Food Animal Residue Avoidance Databank (FARAD) is a major effort to compile into a single source large amounts of information on veterinary pharmaceutics, pharmacokinetics and physiochemical properties of drugs and other chemicals used in livestock production.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1986 journal article
Food Animal Residue Avoidance Databank (FARAD): An Automated Pharmacologic Databank for Drug and Chemical Residue Avoidance
Journal of Food Protection, 49(10), 826–830.
TL;DR:
The Food Animal Residue Avoidance Databank (FARAD) is a comprehensive computerized databank of regulatory and pharmacologic information useful for mitigation of drug and chemical residue problems in food-producing animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
1986 conference paper
Gentamicin nephrotoxicity in normal and subtotal nephrectomized dogs with identical serum drug concentration profiles
The Toxicologist, 6, 175.
Event: 25th Meeting of the Society of Toxicology at New Orleans, LA on March 3-7, 1986
Source: NC State University Libraries
Added: October 28, 2022
1986 journal article
Identification of a subgroup of Sprague Dawley rats highly sensitive to drug induced renal toxicity
Fundamental and Applied Toxicology, 7, 126–131.
Source: NC State University Libraries
Added: August 6, 2018
1986 conference paper
Identification of a subgroup of Sprague-Dawley rats highly sensitive to drug induced renal toxicity
The Toxicologist, 6, 176.
Event: 25th Meeting of the Society of Toxicology at New Orleans, LA on March 3-7, 1986
Source: NC State University Libraries
Added: October 28, 2022
1986 journal article
Increased gentamicin nephrotoxicity in normal and diseased dogs administered identical serum drug concentration profiles: Increased sensitivity in subclinical renal dysfunction
Journal of Pharmacology and Experimental Therapeutics, 239, 946–951.
Source: NC State University Libraries
Added: August 6, 2018
1986 journal article
Influence of thyroid function on the pharmacokinetics of gentamicin in pigs
American Journal of Veterinary Research, 47, 2141–2146.
Source: NC State University Libraries
Added: August 6, 2018
1986 conference paper
Morphologic assessment of viability and toxicity in the isolated perfused porcine skin flap
The Toxicologist, 6, 242.
Event: 25th Meeting of the Society of Toxicology at New Orleans, LA on March 3-7, 1986
Source: NC State University Libraries
Added: October 28, 2022
1986 conference paper
Nephrotoxicity in subtotally nephrectomized rats receiving gentamicin for different periods and dosage reduction regimens
The Toxicologist, 6, 176.
Event: 25th Meeting of the Society of Toxicology at New Orleans, LA on March 3-7, 1986
Source: NC State University Libraries
Added: October 28, 2022
1986 conference paper
Percutaneous absorption of caffeine and malathion in the isolated perfused porcine skin flap
The Toxicologist, 6, 243.
Event: 25th Meeting of the Society of Toxicology at New Orleans, LA on March 3-7, 1986
Source: NC State University Libraries
Added: October 28, 2022
1986 conference paper
Pharmacokinetics and toxicity of intraperitoneal cisplatin plus regional hyperthermia
Proceedings of the American Society for Therapeutic Radiology and Oncology, 12(S1), 154.
Event: 28th Annual Meeting of American society for therapeutic radiology and oncology at Los Angeles, CA on November 2-7, 1986
Source: NC State University Libraries
Added: December 10, 2022
1986 journal article
Prediction of pharmacokinetic profiles of ampicillin sodium, gentamicin sulfate, and combination ampicillin sodium gentamicin sulfate in serum and synovial fluid of normal horses
American Journal of Veterinary Research, 47, 1590–1596.
Source: NC State University Libraries
Added: August 6, 2018
1986 journal article
Prediction of renal gentamicin residues in sheep using power functions
Federation Proceedings, 45, 207.
Source: NC State University Libraries
Added: May 6, 2023
1986 chapter
Proper antibiotic usage and dosage
In Antibiotics: the right choice (pp. 5–16). Princeton Junction, NJ: Veterinary Learning Systems.
Source: NC State University Libraries
Added: August 6, 2018
1986 journal article
Research methods in percutaneous absorption.
Journal of the American Veterinary Medical Association, 189, 355.
Source: NC State University Libraries
Added: October 15, 2022
1986 article
SUPERIORITY OF THE POWER FUNCTION OVER EXPONENTIAL FUNCTIONS FOR PREDICTION OF RENAL GENTAMICIN RESIDUES IN SHEEP
BROWN, S. A., RIVIERE, J. E., COPPOC, G. L., & DIX, L. P. (1986, September). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 9, pp. 341–346.
MeSH headings : Animals; Drug Administration Schedule; Gentamicins / administration & dosage; Gentamicins / metabolism; Injections, Intramuscular; Kidney / analysis; Kinetics; Mathematics; Sheep / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1986 conference paper
Septic arthritis in horses. A prospective study
Veterinary Surgery, 15(1), 114.
Event: 21st Annual Meeting of the American College of Veterinary Surgeons at Orlando, FL on February 26, 1986
Source: NC State University Libraries
Added: December 10, 2022
1986 journal article
THE ISOLATED PERFUSED PORCINE SKIN FLAP (IPPSF) .1. A NOVEL INVITRO MODEL FOR PERCUTANEOUS-ABSORPTION AND CUTANEOUS TOXICOLOGY STUDIES
FUNDAMENTAL AND APPLIED TOXICOLOGY, 7(3), 444–453.
Contributors: n, K. Bowman n, N. Monteiroriviere n, L. Dix n & M. Carver n
MeSH headings : Animals; Blood Pressure; Glucose / metabolism; In Vitro Techniques; Models, Biological; Perfusion; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Absorption; Swine
TL;DR:
A single-pedicle, axial-pattern, island-tubed skin flap was created in crossbred Yorkshire weanling pigs in one surgical procedure, then transferred 2 or 6 days later to a computer-controlled temperature-regulated perfusion chamber for 10-to 12-hr studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1986 conference paper
The Food Animal Residue Avoidance Databank (FARAD): A computer databank of the pharmacokinetics of drugs, pesticides and environmental chemicals in food animals
Comparative veterinary pharmacology, toxicology, and therapy: proceedings of the 3rd Congress of the European Association for Veterinary Pharmacology and Toxicology, August 25-29, 1985, Ghent, Belgium, 3, 225–231. Boston: MTP Press Ltd.
Source: NC State University Libraries
Added: August 6, 2018
1986 conference paper
The food animal residue avoidance databank: FARAD
Proceedings of the International Conference Cooperative Agriculture Extension Programs.
Source: NC State University Libraries
Added: May 6, 2023
1986 chapter
The isolated perfused porcine skin flap: A novel animal for cutaneous toxicologic research
In Swine in biomedical research (pp. 657–666). New York: Plenum Press.
Source: NC State University Libraries
Added: August 6, 2018
1986 conference paper
The isolated perfused porcine skin flap: A novel model for skin biology
Veterinary Surgery, 15(1), 114.
Event: 21st Annual Meeting of the American College of Veterinary Surgeons at Orlando, FL on February 26, 1986
Source: NC State University Libraries
Added: December 10, 2022
1985 journal article
Acute toxicity of sodium fluoride in an isolated perfused porcine skin flap
Pharmacologist, 27, 158.
Source: NC State University Libraries
Added: September 23, 2022
1985 chapter
Aminoglycoside-induced toxic nephropathy
In CRC handbook of animal models of renal failure (pp. 145–182). Boca Raton, FL: CRC Press Inc.
Source: NC State University Libraries
Added: August 6, 2018
1985 chapter
Clinical management of toxicoses and adverse drug reactions
In Handbook of small animal therapeutics (pp. 657–683). New York: Churchill Livingstone, Inc.
Source: NC State University Libraries
Added: August 6, 2018
1985 journal article
DOSE-RESPONSE STUDIES OF GENTAMICIN-NEPHROTOXICITY IN RATS WITH EXPERIMENTAL RENAL DYSFUNCTION .1. SUBTOTAL SURGICAL NEPHRECTOMY
TOXICOLOGY AND APPLIED PHARMACOLOGY, 80(2), 251–263.
MeSH headings : Absorption; Analysis of Variance; Animals; Gentamicins / metabolism; Gentamicins / toxicity; Gentamicins / urine; Glomerular Filtration Rate / drug effects; Injections, Subcutaneous; Kidney / metabolism; Kidney / physiology; Kidney Diseases / chemically induced; Kidney Diseases / pathology; Kinetics; Male; Nephrectomy; Rats; Rats, Inbred Strains
TL;DR:
The relatively lower nephrotoxicity in the FD regimen in rats agrees with results previously reported in dogs, thus indicating that the method of dose reduction in patients with compromised renal function may be a significant factor in lowering neph rotoxic potential.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1985 journal article
DOSE-RESPONSE STUDIES OF GENTAMICIN-NEPHROTOXICITY IN RATS WITH EXPERIMENTAL RENAL DYSFUNCTION .2. POLYVINYL-ALCOHOL GLOMERULOPATHY
TOXICOLOGY AND APPLIED PHARMACOLOGY, 80(2), 264–273.
Contributors: M. Carver n, N. Monteiroriviere n, T. Brown n & n
MeSH headings : Animals; Carbon Radioisotopes; Gentamicins / metabolism; Gentamicins / toxicity; Glomerular Mesangium / drug effects; Glomerular Mesangium / physiology; Glomerular Mesangium / ultrastructure; Glomerulonephritis / chemically induced; Glomerulonephritis / physiopathology; Half-Life; Injections, Subcutaneous; Kidney Function Tests; Kinetics; Male; Nephrectomy; Polyvinyl Alcohol / toxicity; Rats; Rats, Inbred Strains; Tetraethylammonium; Tetraethylammonium Compounds / metabolism
TL;DR:
Altered gentamicin nephrotoxicity in rats with an otherwise benign glomerulopathy is demonstrated and similar conclusions from a related study in subtotally nephrectomized rats are presented, presenting further evidence that the underlying pathophysiologic state of the kidney is an important factor in the renal response to neph Rotoxins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
1985 journal article
Decreased fractional renal excretion of gentamicin in the subtotal nephrectomized dog
Journal of Pharmacology and Experimental Therapeutics, 234, 90–93.
Source: NC State University Libraries
Added: August 6, 2018
1985 report
Development of in vitro isolated perfused porcine skin flaps for study of percutaneous absorption of xenobiotics
In DAMD17-84-C-4103, NTIS, ADA 183580 (pp. 1–32). Bethesda, MD: NTIS.
Source: NC State University Libraries
Added: August 6, 2018
1985 conference paper
Development of surgical techniques for in vitro isolated perfused skin flaps for percutaneous absorption of xenobiotics
Proceedings of the Fifth Annual Chemical Defense Bioscience Review. USAMRICD Report #SP 85-051, App III, A927–939. Columbia, MD: USAMRICD Report SP85 05.
Source: NC State University Libraries
Added: August 6, 2018
1985 conference paper
Development of surgical techniques for preparation of in vitro isolated perfused porcine skin flaps for study of percutaneous absorption of xenobiotics
[USAMRICD Report]. Abstracts of 5th Annual Chemical Defense Bioscience Review, (Appendix III), A927–A939. https://apps.dtic.mil/sti/pdfs/ADB104129.pdf
Event: 5th Annual Chemical Defense Bioscience Review at Columbia, MD on May 29-31, 1985
Source: NC State University Libraries
Added: December 30, 2022
1985 conference paper
Effects of disease on drug binding to serum proteins.
Third European Association for Veterinary Pharmacology and Toxicology, 215.
Event: Third European Association for Veterinary Pharmacology and Toxicology at Ghent, Belgium on September 25-29, 1985
Source: NC State University Libraries
Added: October 15, 2022
1985 conference paper
Effects of pre-existing renal disease on aminoglycoside nephrotoxicity in dogs and rats
Renal heterogeneity and target cell toxicity : proceedings of the Second International Symposium on Nephrotoxicity, University of Surrey, UK, 6-9 August 1984, 339–344. Chichester: John Wiley and Sons Ltd.
Source: NC State University Libraries
Added: August 6, 2018
1985 conference paper
Exaggerated response to gentamicin-induced nephrotoxicity in Sprague-Dawley rats: Identification of an outlier population
Fourth International Symposium on Renal Pathology and Toxicology, 21.
Source: NC State University Libraries
Added: May 6, 2023
1985 book review
Experimental and Clinical Pharmacokinetics
[Review of Experimental and Clinical Pharmacokinetics, by A. Yacobi & H. Barry]. Journal of pharmaceutical sciences, 74(8), 909.
Source: NC State University Libraries
Added: December 10, 2022
1985 conference paper
Food animal residue avoidance databank
74th Annual Poultry Science Proceedings, 83.
Source: NC State University Libraries
Added: August 6, 2018
1985 journal article
Food animal residue avoidance databank (FARAD)
Journal of the American Veterinary Medical Association, 186, 939.
Source: NC State University Libraries
Added: December 10, 2022
1985 conference paper
Gentamicin toxicity in rats with prior renal insufficiency
The Toxicologist, 5, 1.
Event: 24th Annual Meeting of the Society of Toxicology at San Diego, CA on March 18-22, 1985
Source: NC State University Libraries
Added: October 28, 2022
1985 conference paper
Influence of thyroid function on the pharmacokinetics of gentamicin.
Third European Association for Veterinary Pharmacology and Toxicology, 115.
Event: Third European Association for Veterinary Pharmacology and Toxicology at Ghent, Belgium on September 25-29, 1985
Source: NC State University Libraries
Added: October 15, 2022
1985 journal article
Pharmacokinetics of digoxin in sheep: Limitations of the use of biological half life for interspecies extrapolation
American Journal of Veterinary Research, 46, 470–472.
Source: NC State University Libraries
Added: August 6, 2018
1985 journal article
Renal handling of gentamicin in subtotal nephrectomized dogs and rats
Pharmacologist, 27, 170.
Source: NC State University Libraries
Added: September 23, 2022
1985 conference paper
Role of therapeutic drug monitoring in the design and execution of clinical trials
In J. D. Powers & T. E. Powers (Eds.), Symposium on Clinical Trials with Therapeutic Drugs in Animals (1985 : Alexandria, Va.) (pp. 182–189). Columbus, OH: Ohio State University Press.
Ed(s): J. Powers & T. Powers
Source: NC State University Libraries
Added: August 6, 2018
1985 journal article
Single intravenous and multiple intramuscular dose pharmacokinetics and tissue residue profile of gentamicin in sheep
American Journal of Veterinary Research, 46, 69–74.
Source: NC State University Libraries
Added: August 6, 2018
1985 book
The food animal residue avoidance databank (FARAD): A computer databank of the pharmacokinetics of drugs, pesticides and environmental contaminants in food animals.
In Third European Association for Veterinary Pharmacology and Toxicology. Presented at the Third European Association for Veterinary Pharmacology and Toxicology, Ghent, Belgium.
Event: Third European Association for Veterinary Pharmacology and Toxicology at Ghent, Belgium on September 25-29, 1985
Source: NC State University Libraries
Added: October 15, 2022
1985 conference paper
The isolated perfused porcine skin flap: A novel in vitro animal model system for drug and xenobiotic percutaneous absorption studies
Proceedings of the Fifth Annual Chemical Defense Bioscience Review, Appendix 3, A-911–926. Columbia, MD.
Event: Fifth Annual Chemical Defense Bioscience Review at Johns Hopkins University Applied Physics Laboratory on May 29-31, 1985
Source: NC State University Libraries
Added: August 6, 2018
1985 conference paper
The relevance of drug binding and disease state to therapeutic drug monitoring
Conference of Research Workers in Animal Diseases., 66, 83.
Source: NC State University Libraries
Added: May 6, 2023
1984 journal article
ADVERSE DRUG-REACTIONS IN CATS WITH FELINE URETHRAL OBSTRUCTION
VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE, 14(3), 703–709.
MeSH headings : Animals; Cat Diseases / physiopathology; Cats; Drug-Related Side Effects and Adverse Reactions; Kidney / metabolism; Pharmaceutical Preparations / metabolism; Uremia / etiology; Uremia / physiopathology; Uremia / veterinary; Urethral Obstruction / complications; Urethral Obstruction / physiopathology; Urethral Obstruction / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1984 journal article
APPLICATION OF BIPLOT METHODS TO THE MULTIVARIATE-ANALYSIS OF TOXICOLOGICAL AND PHARMACOKINETIC DATA
TOXICOLOGY AND APPLIED PHARMACOLOGY, 72(1), 91–101.
MeSH headings : Analysis of Variance; Animals; Dogs; Female; Gentamicins / toxicity; Kidney / drug effects; Kinetics; Nephrectomy; Pharmaceutical Preparations / metabolism; Toxicology
TL;DR:
The biplot technique proved to be a very useful tool in exploring this type of data by revealing clear relationships between nephrotoxicity and physiological and pharmacokinetic variables and by separating different disease states based on these data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1984 journal article
Calculation of dosage regimens of antimicrobial drugs in animals with renal and hepatic dysfunction
Journal of the American Veterinary Medical Association, 185, 1094–1097.
Source: NC State University Libraries
Added: August 6, 2018
1984 journal article
Effects of familial hypothyroidism and subtotal surgical nephrectomy on gentamicin pharmacokinetics in beagle dogs
Chemotherapy, 30, 216–220.
MeSH headings : Animals; Dogs; Gentamicins / metabolism; Half-Life; Hypothyroidism / genetics; Hypothyroidism / metabolism; Hypothyroidism / physiopathology; Kinetics; Nephrectomy
TL;DR:
Gentamicin serum pharmacokinetics were studied in normal, subtotally nephrectomized, and familial hypothyroid beagle dogs and length of the gamma phase was not affected by subtotal neph rectomy but was shorter or almost nonexistent in hypothy thyroid dogs.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
1984 journal article
Effects of pre-existing renal disease on aminoglycosides nephrotoxicity in dogs and rats
Human Toxicology, 3(5), 429.
Event: Second International Symposium on Nephrotoxicity at University of Surrey, Guilford, Surrey, UK on August 6-19, 1984
Source: NC State University Libraries
Added: October 28, 2022
1984 journal article
PHARMACOKINETICS AND COMPARATIVE NEPHROTOXICITY OF FIXED-DOSE VERSUS FIXED-INTERVAL REDUCTION OF GENTAMICIN DOSAGE IN SUBTOTAL NEPHRECTOMIZED DOGS
TOXICOLOGY AND APPLIED PHARMACOLOGY, 75(3), 496–509.
MeSH headings : Analysis of Variance; Animals; Dogs; Female; Gentamicins / administration & dosage; Gentamicins / metabolism; Gentamicins / toxicity; Kidney / drug effects; Kidney / pathology; Kinetics; Metabolic Clearance Rate; Nephrectomy
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1984 chapter
Renal handling of drugs in renal failure
In Canine nephrology (pp. 643–685). Media, PA: Harwal Publishers.
Source: NC State University Libraries
Added: August 6, 2018
1984 journal article
Support of an anephric dog for 54 days with ambulatory peritoneal dialysis and a newly designed peritoneal catheter
American Journal of Veterinary Research, 45, 1156–1161.
Source: NC State University Libraries
Added: August 6, 2018
1984 conference paper
The value and limitation of pharmacokinetics in predicting dose regimens: Effects of systemic disease
Proceedings of a Symposium on the Determination of Doses of Veterinary Pharmaceuticals (Columbus), 99–118. Ohio State University Press.
Source: NC State University Libraries
Added: August 6, 2018
1983 chapter
Adverse drug reactions
In Current veterinary therapy VIII: small animal practice (Vol. 8, pp. 122–128). Philadelphia: WB Saunders Co.
Source: NC State University Libraries
Added: August 6, 2018
1983 journal article
Application of biplot methods to the multivariate analysis of toxicological and pharmacokinetic data.
Pharmacologist, 25, 232.
Source: NC State University Libraries
Added: October 15, 2022
1983 chapter
Checklist of hazardous drugs in patients with renal failure
In Current veterinary therapy VIII: small animal practice (Vol. 8, pp. 1036–1041). Philadelphia: WB Saunders Co.
Source: NC State University Libraries
Added: August 6, 2018
1983 journal article
MORPHOLOGICAL AND FUNCTIONAL-ASPECTS OF EXPERIMENTAL GENTAMICIN-NEPHROTOXICITY IN YOUNG BEAGLES AND FOALS
VETERINARY RESEARCH COMMUNICATIONS, 7(1-4), 211–213.
MeSH headings : Animals; Dogs; Gentamicins / toxicity; Horses; Kidney / drug effects; Kidney / pathology; Kidney / physiopathology; Kidney Diseases / chemically induced; Kidney Diseases / pathology; Kidney Diseases / physiopathology
TL;DR:
Results indicated that a single 15 mg/kg dose of gentamicin administered to beagles produced subclinical functional and morphological changes in the kidney, suggesting an enhanced susceptibility of young horses to clinical renal dysfunction.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
1983 journal article
Peritonitis associated with peritoneal dialysis. Diagnosis and treatment
Journal of the American Veterinary Medical Association, 182, 721–724.
Source: NC State University Libraries
Added: August 6, 2018
1983 conference paper
Pharmacokinetics of digoxin in sheep: An example of the utility of student laboratory exercises
Abstracts of papers presented at the 64th Annual Meeting of the Conference of Research Workers in Animal Disease, 15.
Event: 64th Conference of Research Workers in Animal Diseases at Chicago, IL on November 14-15, 1983
Source: NC State University Libraries
Added: December 10, 2022
1983 conference paper
Physiologic determinants of gentamicin gamma phase pharmacokinetics in the dog. Effects of subtotal surgical nephrectomy and familiar hypothyroidism
Abstracts of papers presented at the 64th Annual Meeting of the Conference of Research Workers in Animal Disease, 15.
Event: 64th Conference of Research Workers in Animal Diseases at Chicago, IL on November 14-15, 1983
Source: NC State University Libraries
Added: December 10, 2022
1983 journal article
SPECIES DEPENDENT GENTAMICIN PHARMACOKINETICS AND NEPHROTOXICITY IN THE YOUNG HORSE
FUNDAMENTAL AND APPLIED TOXICOLOGY, 3(5), 448–457.
MeSH headings : Age Factors; Animals; Gentamicins / metabolism; Gentamicins / toxicity; Horses; Injections, Intramuscular; Injections, Intravenous; Kidney / drug effects; Kinetics; Metabolic Clearance Rate; Species Specificity
TL;DR:
The results support the clinical impression that very young horses may be more susceptible than adult horses, and adults of other species, to gentamicin nephrotoxic potential.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
1983 chapter
Toxicology and pharmacology
In Feline medicine (Vol. 3, pp. 62–78). Santa Barbara, CA: American Veterinary Publications, Inc.
Source: NC State University Libraries
Added: August 6, 2018
1983 book review
Veterinary Pharmacology and Therapeutics
[Review of Veterinary Pharmacology and Therapeutics, by N. H. Booth & L. E. McDonald]. Journal of the American Veterinary Medical Association, 182, 402.
Source: NC State University Libraries
Added: October 15, 2022
1982 journal article
A possible mechanism for increased susceptibility to aminoglycoside nephrotoxicity in chronic renal disease
New England Journal of Medicine, 307, 252–253.
MeSH headings : Acute Disease; Aftercare; Humans; Infant; Otitis Media / therapy; Recurrence
Source: NC State University Libraries
Added: August 6, 2018
1982 journal article
Ampicillin in mares: A comparison of intramuscular sodium ampicillin or sodium ampicillin ampicillin trihydrate injection
American Journal of Veterinary Research, 43, 402–404.
Source: NC State University Libraries
Added: August 6, 2018
1982 chapter
Basic principles of antibiotic use
In Bristol veterinary handbook of antimicrobial therapy (pp. 6–11). Princeton Junction, NJ: Veterinary Learning Systems Inc.
Source: NC State University Libraries
Added: August 6, 2018
1982 conference paper
Comparative nephrotoxicity of fixed-dose versus fixed-interval reduction of gentamicin dosage in partially nephrectomized dogs.
Proceedings of the 22nd Interscience Conference on Antimicrobial Agents and Chemotherapy, 22, 74.
Event: 22nd Interscience Conference on Antimicrobial Agents and Chemotherapy at Miami Beach, FL.
Source: NC State University Libraries
Added: October 21, 2022
1982 chapter
Drug use in the presence of liver and kidney disease
In Bristol veterinary handbook of antimicrobial therapy (pp. 214–217). Princeton Junction, NJ: Veterinary Learning Systems Inc.
Source: NC State University Libraries
Added: August 6, 2018
1982 journal article
Gentamicin nephrotoxicity in horses. Clinical and experimental evidence
Audio Veterinary Medicine Journal, VEQ-601.
Source: NC State University Libraries
Added: May 6, 2023
1982 journal article
Gentamicin nephrotoxicity in horses: Clinical-experimental evidence.
Journal of the American Veterinary Medical Association, 181, 270.
Source: NC State University Libraries
Added: October 21, 2022
1982 conference paper
Gentamicin pharmacokinetics and tissue disposition in beagles.
Proceedings of 3rd Symposium of the American Academy of Veterinary Pharmacology and Therapeutics, 3, 209.
Event: 3rd Symposium of the American Academy of Veterinary Pharmacology and Therapeutics at Fawcett Center for Tomorrow, Ohio State University, Columbus, Ohio on April 13-15, 1982
Source: NC State University Libraries
Added: October 15, 2022
1982 journal article
Gentamicin toxic nephropathy in horses with disseminated bacterial infection
Journal of the American Veterinary Medical Association, 180, 648–651.
Source: NC State University Libraries
Added: August 6, 2018
1982 journal article
Limitations on the physiologic interpretation of aminoglycoside body clearance derived from pharmacokinetic studies
Research Communications in Chemical Pathology and Pharmacology, 38, 31–42.
Source: NC State University Libraries
Added: August 6, 2018
1982 personal communication
PARADOXICAL INCREASE IN AMINOGLYCOSIDE BODY CLEARANCE IN RENAL-DISEASE WHEN VOLUME OF DISTRIBUTION INCREASES
MeSH headings : Aminoglycosides / metabolism; Animals; Anti-Bacterial Agents / metabolism; Dogs; Glomerular Filtration Rate; Humans; Kidney Diseases / metabolism; Kinetics; Sheep
Source: Web Of Science
Added: August 6, 2018
1982 journal article
Pharmacokinetics of gentamicin in the juvenile dog.
Journal of the American Veterinary Medical Association, 180, 626.
Source: NC State University Libraries
Added: October 15, 2022
1982 chapter
The aminoglycosides
In Bristol veterinary handbook of antimicrobial therapy (pp. 186–189). Princeton Junction, NJ: Veterinary Learning Systems Inc.
Source: NC State University Libraries
Added: August 6, 2018
1982 chapter
Toxicity and interactions
In Bristol veterinary handbook of antimicrobial therapy (pp. 204–213). Princeton Junction, NJ: Veterinary Learning Systems Inc.
Source: NC State University Libraries
Added: August 6, 2018
1981 conference paper
A field investigation of environmental arsenic toxicosis in cattle.
Proceedings of the American Association of Veterinary Laboratory Diagnosticians, 24.
Event: 24th Annual Meeting American Association of Veterinary Laboratory Diagnosticians
Source: NC State University Libraries
Added: October 28, 2022
1981 conference paper
Arsenic induced hemorrhagic enterocolitis in cattle
Proceedings of the American Association of Veterinary Laboratory Diagnosticians, 23, 397–404.
Source: NC State University Libraries
Added: May 6, 2023
1981 journal article
Determination of cerebrospinal fluid gentamicin in the beagle using an indwelling cerebral ventricular cannula
Chemotherapy, 27, 309–312.
MeSH headings : Animals; Catheterization; Cerebral Ventricles; Dogs; Gentamicins / cerebrospinal fluid; Inflammation / cerebrospinal fluid; Kinetics
TL;DR:
The use of an indwelling ventricular cannula was effective for the long-term monitoring of CSF drug levels and significant levels of gentamicin were detected in the CSF shortly after injection in the absence of inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
1981 journal article
Dosage of antimicrobial drugs in patients with renal insufficiency
Journal of the American Veterinary Medical Association, 178, 70–72.
Source: NC State University Libraries
Added: August 6, 2018
1981 journal article
GENTAMICIN PHARMACOKINETIC CHANGES IN INDUCED ACUTE CANINE NEPHROTOXIC GLOMERULONEPHRITIS
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 20(3), 387–392.
MeSH headings : Acute Disease; Animals; Dogs; Gentamicins / metabolism; Glomerulonephritis / metabolism; In Vitro Techniques; Kidney Function Tests; Kinetics; Male
TL;DR:
It is suggested that the assumption of unchanged volume of distribution in acute glomerulonephritis could lead to a serious overestimation of serum drug concentration.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1981 journal article
Gentamicin aerosol therapy in 18 dogs: Failure to induce detectable serum concentrations of the drug
Journal of the American Veterinary Medical Association, 179, 166–168.
Source: NC State University Libraries
Added: August 6, 2018
1981 thesis
Gentamicin in the young beagle dog: Pharmacokinetics, nephrotoxicity and behavior in a model of glomerulonephritis
(PhD Thesis). Purdue University.
Source: NC State University Libraries
Added: May 6, 2023
1981 journal article
Inorganic arsenic toxicosis in cattle. A review of selected cases
Modern Veterinary Practice, 62, 209–211.
Source: NC State University Libraries
Added: August 6, 2018
1981 journal article
Penicillin and ampicillin therapy in horses
Journal of the American Veterinary Medical Association, 178, 1186–1189.
Source: NC State University Libraries
Added: August 6, 2018
1981 conference paper
Pharmacokinetics and tissue disposition of gentamicin in sheep
Proceedings of the 62nd Annual Meeting of the Conference of Research Workers in Animal Disease, 62, 13.
Event: 62nd Annual Meeting of the Conference of Research Workers in Animal Disease at Chicago, IL on November 9-10, 1981
Source: NC State University Libraries
Added: December 10, 2022
1981 journal article
Pharmacokinetics of gentamicin in the juvenile dog
American Journal of Veterinary Research, 42, 1621–1623.
Source: NC State University Libraries
Added: August 6, 2018
1981 journal article
Prophylactic use of systemic antimicrobial drugs in surgery
Compendium on Continuing Education for the Practicing Veterinarian, 3, 345–355.
Source: NC State University Libraries
Added: August 6, 2018
1981 journal article
Selected aspects of aminoglycoside antibiotic nephrotoxicosis
Journal of the American Veterinary Medical Association, 178, 508–509.
Source: NC State University Libraries
Added: August 6, 2018
1981 journal article
Single dose gentamicin nephrotoxicity in the dog. Early functional and ultrastructural changes
Research Communications in Chemical Pathology and Pharmacology, 33, 403–418.
Source: NC State University Libraries
Added: August 6, 2018
1981 journal article
Single dose gentamicin nephrotoxicity in the young beagle: Subcellular morphological changes.
Kidney International, 19(1), 212.
Event: American Society of Nephrology Meeting at Washington, D.C. on November 23-25, 1980
Source: NC State University Libraries
Added: October 21, 2022
1981 conference paper
Three compartment accumulation pharmacokinetics and tissue disposition of gentamicin in the dog
Proceedings of the 62nd Annual Meeting of the Conference of Research Workers in Animal Disease, 62, 13.
Event: 62nd Annual Meeting of the Conference of Research Workers in Animal Disease at Chicago, IL on November 9-10, 1981
Source: NC State University Libraries
Added: December 10, 2022
1981 conference paper
Toxicokinetics of gentamicin in the young horse
Proceedings of the Annual Meeting of the Conference of Research Workers in Animal Disease, 62, 13.
Event: 62nd Annual Meeting of the Conference of Research Workers in Animal Disease at Chicago, IL on November 9-10, 1981
Source: NC State University Libraries
Added: December 30, 2022
1980 conference paper
Gentamicin nephrotoxicity in young beagles
Federation Proceedings, 39, 859.
Source: NC State University Libraries
Added: May 6, 2023
1980 conference paper
Gentamicin pharmacokinetic changes in acute canine nephrotoxic glomerulonephritis
[Abstract]. Proceedings of the Annual Meeting of the Conference of Research Workers in Animal Disease, 61, 4.
Event: 61st Annual Meeting of the Conference of Research Workers in Animal Disease at Chicago, IL on November 10-11, 1980
Source: NC State University Libraries
Added: December 30, 2022
1980 journal article
Polyvinyl alcohol toxicosis as a model of glomerulonephritis in beagle dogs
American Journal of Veterinary Research, 41, 502–555.
Source: NC State University Libraries
Added: August 6, 2018
1979 conference paper
Cerebrospinal fluid levels of gentamicin in young beagles
Proceedings of the Annual Meeting of the Conference of Research Workers in Animal Disease, 60, 31.
Event: 60th Annual Meeting of the Conference of Research Workers in Animal Disease at Chicago, IL on November 26-27, 1979
Source: NC State University Libraries
Added: December 30, 2022
1979 journal article
Percutaneous absorption of gentamicin by the leopard frog (Rana pipiens)
Journal of Veterinary Pharmacology and Therapeutics, 2, 235–239.
Source: NC State University Libraries
Added: August 6, 2018
1979 conference paper
Phenolsulfonphthalein (PSP) disappearance in horses as an estimate of renal tubular function.
Sixth Equine Nutrition and Physiology Symposium. Presented at the Sixth Equine Nutrition and Physiology Symposium, Texas A&M University, College Station, TX.
Event: Sixth Equine Nutrition and Physiology Symposium at Texas A&M University, College Station, TX on May 17-19, 1979
Source: NC State University Libraries
Added: November 23, 2022
1978 journal article
MOLTING IN HARBOR SEAL [PHOCA-VITULINA] AND ITS POSSIBLE SIGNIFICANCE TO EXOTIC ANIMAL MEDICINE
JOURNAL OF ZOO ANIMAL MEDICINE, 9(2), 46–52.
Source: Web Of Science
Added: August 6, 2018
1978 conference paper
Polyvinyl alcohol toxicosis in beagle dogs
Proceedings of the Annual Meeting of the Conference of Research Workers in Animal Disease, 59, 7.
Event: 59th Annual Meeting of the Conference of Research Workers in Animal Disease at Chicago, IL on November 27-28, 1978
Source: NC State University Libraries
Added: December 30, 2022
1977 journal article
RELATIONSHIP OF THYROXINE AND CORTISOL TO MOLT OF HARBOR SEAL PHOCA-VITULINA
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 31(4), 398–401.
MeSH headings : Animals; Caniformia / physiology; Female; Hair / physiology; Hydrocortisone / blood; Male; Seals, Earless / physiology; Seasons; Skin Physiological Phenomena; Thyroxine / blood; Time Factors
TL;DR:
Studies on the harbor seal indicate that there is a relationship between the annual moult and the blood plasma titers of thyroxine and cortisol, and when the moult is complete and hair growth resumes, Thyroxine increases and cortisol returns to a baseline level.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
conference paper
A comparison of trends in partitioning of 32 aliphatic and aromatic jet fuel constituents in various SPME/solvent matrices
Barlow, B. M., Baynes, R. E., Xia, X. R., & Riviere, J. E. The Toxicologist, 96(S1), 430. https://www.toxicology.org/pubs/docs/Tox/2007Tox.pdf
Event: 46th Annual Meeting and ToxExpo at Charlotte, NC on March 25-29, 2007
Source: NC State University Libraries
Added: August 20, 2022
chapter
A novel system coefficient approach for systematic assessment of dermal absorption from chemical mixtures
Xia, X. R., Baynes, R. E., & Riviere, J. E. In Dermal absorption models in toxicology and pharmacology (pp. 69–86). New York: Taylor and Francis / CRC Press.
Source: NC State University Libraries
Added: August 6, 2018
conference paper
Biological surface adsorption index (BSAQI) for characterizing carbon nanomaterials with different surface chemistries in biological systems
Xia, X. R., Monteiro-Riviere, N. A., & Riviere, J. E. [Abstract]. The Toxicologist, 120(2), 251. https://www.toxicology.org/pubs/docs/Tox/2011Tox.pdf
Event: 50th Anniversary Annual Meeting and ToxExpo at Washington, D.C. on March 6-10, 2011
Source: NC State University Libraries
Added: June 17, 2022
conference paper
Cellular mechanisms of quantum dot nanoparticle uptake in primary human epidermal keratinocytes
Ryman-Rasmussen, J. P., Riviere, J. E., & Monteiro-Riviere, N. A. The Toxicologist, 96(S1), 289. https://www.toxicology.org/pubs/docs/Tox/2007Tox.pdf
Event: 46th Annual Meeting and ToxExpo at Charlotte, NC on March 25-29, 2007
Source: NC State University Libraries
Added: August 20, 2022
journal article
Epidermal cytotoxicity of topically-applied chemical mixtures in porcine skin
Monteiro-Riviere, N. A., Baynes, R., & Riviere, J. Journal of Veterinary Pharmacology and Therapeutics, 20(1997), 255–256.
Source: NC State University Libraries
Added: August 6, 2018
conference paper
Extralabel Withdrawal-interval Estimator (EWE) algorithm. An automated approach to establishing extralabel withdrawal times
Martin-Jimenez, T., Baynes, R., Craigmill, A., & Riviere, J. Proceedings of the 11th Biennial Symposium of American Acadamic Veterinary Pharmacologic Therapeutics, 11, 49–63.
Source: NC State University Libraries
Added: August 6, 2018
book
Food Animal Residue Avoidance Databank trade name file : a comprehensive compendium of food animal drugs
Sundlof, S. F., Riviere, J. E., & Craigmill, A. L. (9th ed.). Gainesville, FL.: University of Florida Press.
Source: NC State University Libraries
Added: December 10, 2022
book
Food Animal Residue Avoidance Databank trade name file : a comprehensive compendium of food animal drugs
Sundlof, S. F., Riviere, J. E., & Craigmill, A. L. (8th ed.). Gainesville, FL.: University of Florida Press.
Source: NC State University Libraries
Added: December 10, 2022
book
Food Animal Residue Avoidance Databank trade name file : a comprehensive compendium of food animal drugs
Sundlof, S. F., Riviere, J. E., & Craigmill, A. L. (7th ed.). Gainesville, FL.: University of Florida Press.
Source: NC State University Libraries
Added: December 10, 2022
report
Method and Composition for Iontophoresis
Sage, B., & Riviere, J. E. (Japanese Patent No. #1972677).
Source: NC State University Libraries
Added: December 30, 2022
patent
Method and apparatus for determining a molecular descriptor of absorption for a candidate compound
Riviere, J. E., Xia, X. R., Baynes, R. E., & Monteiro-Riviere, N. A.
Source: NC State University Libraries
Added: August 6, 2018
journal article
NDELA and nickel modulation of triazine disposition in skin
Baynes, R. E., Brooks, J. D., Barlow, B. M., & Riviere, J. E. Toxicology and Industrial Health, 21(9), 197–205.
Source: NC State University Libraries
Added: August 6, 2018
report
Percutaneous absorption of chemical mixtures relevant to the Gulf War
Riviere, J. E., Monteiro-Riviere, N. A., & Baynes, R. E. In Technical report USAMRMC DAMD 17-99C-9047 (pp. 1–162).
Source: NC State University Libraries
Added: August 6, 2018
report
Percutaneous absorption of chemical mixtures relevant to the Gulf War
Riviere, J. E., Baynes, R. E., & Monteiro-Riviere, N. A. In USAMRMC, DAMD17-99C-9047. Technical Report ADB253401 (pp. 1–30).
Source: NC State University Libraries
Added: August 6, 2018
report
Percutaneous absorption of chemical mixtures relevant to the Gulf War. II.
Riviere, J. E., Baynes, R. E., & Monteiro-Riviere, N. A. In Technical report ADB, USAMRMC, DAMD17-99-C-9047 (pp. 1–34).
Source: NC State University Libraries
Added: August 6, 2018
journal article
Protein corona impact on cellular uptake, hepatic functions and molecular mechanisms of action of gold nanoparticle toxicity
Choi, K., Riviere, J. E., & Monteiro-Riviere, N. A. The Toxicologist, 156, 127.
Source: NC State University Libraries
Added: February 5, 2022
report
Quantitating absorption of complex chemical mixtures
Riviere, J. E., Baynes, R. E., & Monteiro-Riviere, N. A. In Final report, CDC OH 007555 (pp. 1–27). Atlanta: Center for Disease Control.
Source: NC State University Libraries
Added: August 6, 2018
report
Quantitating the percutaneous absorption of mechanistically defined chemical mixtures
Riviere, J. E., Baynes, R. E., Smith, C. E., & Monteiro-Riviere, N. A. In NTIS report, AFOSR GF 49620-98-1-0105 (pp. 1–109).
Source: NC State University Libraries
Added: August 6, 2018
report
Quantitating the percutaneous absorption of mechanistically-defined chemical mixtures
Riviere, J. E., Montiero-Riviere, N. A., Baynes, R. E., Xia, X. R., & Smith, C. E. (Vol. 34, p. 1).
Source: NC State University Libraries
Added: August 6, 2018
book
Strategies for reducing drug and chemical residues in food animals: International approaches to residue avoidance, management, and testing
RBaynes, R., & Riviere, J. E. (Eds.). Hoboken, New Jersey: Wiley.
Ed(s): R. RBaynes &
Source: NC State University Libraries
Added: August 6, 2018
chapter
Veterinary dermal absorption and toxicity assessment
Riviere, J. E., & Baynes, R. In Dermal absorption and toxicity assessment (pp. 625–645). New York: Marcel Dekker.
Source: NC State University Libraries
Added: August 6, 2018
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