John Ross Jack

Works (18)

Updated: July 5th, 2023 15:43

2021 journal article

Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome‐Wide Interaction Meta‐Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies

Clinical Pharmacology & Therapeutics, 110(3), 723–732.

By: C. McDonough *, H. Warren *, J. Jack n, A. Motsinger‐Reif *, N. Armstrong *, J. Bis *, J. House* , S. Singh * ...

MeSH headings : Black or African American / genetics; Aged; Antihypertensive Agents / therapeutic use; Blood Pressure / drug effects; Blood Pressure / genetics; Cardiovascular Diseases / chemically induced; Cardiovascular Diseases / genetics; Cardiovascular System / drug effects; Drug-Related Side Effects and Adverse Reactions / etiology; Drug-Related Side Effects and Adverse Reactions / genetics; Female; Genome-Wide Association Study / methods; Humans; Hypertension / drug therapy; Hypertension / genetics; Male; Middle Aged; Pharmacogenomic Testing / methods; Polymorphism, Single Nucleotide / genetics
TL;DR: The NTM region is associated with increased risk for adverse cardiovascular outcomes and less BP reduction in β-blocker treated patients and no SNPs attained genome-wide significance for any other drugs classes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 23, 2021

2020 journal article

The influence of packed cell volume versus plasma proteins on thromboelastographic variables in canine blood

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 30(4), 418–425.

By: A. Lynch n , L. Ruterbories n, J. Jack n, A. Motsinger-Reif n & R. Hanel*

MeSH headings : Animals; Blood Coagulation Tests / veterinary; Blood Proteins / physiology; Cell Size; Dogs / blood; Female; Fibrinogen / metabolism; Hematocrit / veterinary; Male; Thrombelastography / veterinary
TL;DR: In an ex vivo model, plasma proteins but not PCV impacted TEG variables, suggesting that TEG changes noted with anemia are imparted by changes in available fibrinogen in a fixed microenvironment rather than artifact of anemia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 13, 2020

2019 journal article

Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines

FRONTIERS IN GENETICS, 10.

By: K. Roell n, T. Havener *, D. Reif n , J. Jack n, H. McLeod *, T. Wiltshire *, A. Motsinger-Reif*

Contributors: K. Roell n, T. Havener *, D. Reif n , J. Jack n, H. McLeod *, T. Wiltshire *, A. Motsinger-Reif*

author keywords: synergy; heritability; chemotherapy; lymphoblastoid cell lines; linkage mapping
TL;DR: It is demonstrated that synergy occurs and can be quantified in LCLs across a range of clinically important drug combinations, which supports the premise of expanding the use of the LCL model to perform association mapping for combination therapies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 2, 2019

2018 journal article

The influence of Neanderthal alleles on cytotoxic response

PEERJ, 6.

By: F. Akhtari n, T. Havener *, M. Fukudo *, J. Jack n, H. McLeod *, T. Wiltshire *, A. Motsinger-Reif n

author keywords: Neanderthal alleles; Cytotoxic response; Pharmacogenomics; Toxicogenomics; Dose responses; Neanderthal ancestry; Lymphoblastoid cell lines; Anti-cancer drugs; Environmental chemicals; Single nucleotide polymorphisms
TL;DR: The results demonstrate the influence of Neanderthal ancestry-informative markers on cytotoxic response and could be important in identifying biomarkers for personalized medicine or in dissecting the underlying etiology of dose response traits. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 5, 2018

2017 article

Common genetic variants in neurobeachin (nbea) are associated with metformin drug response in individuals with type 2 diabetes in the accord clinical trial

Clinical Pharmacology & Therapeutics, Vol. 101, pp. S9–9.

By: D. Rotroff, S. Marvel, J. Jack, T. Havener, A. Doria, H. Shah, J. Mychaleckyi, H. McLeod ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Gene expression and linkage analysis implicate as a mediator of rituximab resistance

PHARMACOGENOMICS JOURNAL, 18(3), 467–473.

By: J. Jack n, G. Small *, C. Brown*, T. Havener *, H. McLeod *, A. Motsinger-Reif n, K. Richards *

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Antibodies, Monoclonal / administration & dosage; Antibodies, Monoclonal / adverse effects; Antibodies, Monoclonal / genetics; Antigens, CD20 / drug effects; Antigens, CD20 / immunology; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Neoplasm / drug effects; Drug Resistance, Neoplasm / genetics; Female; Gene Expression Regulation, Neoplastic / drug effects; Genetic Linkage; Genome, Human / genetics; Humans; Leukemia, Lymphocytic, Chronic, B-Cell / complications; Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell / genetics; Male; Proto-Oncogene Proteins c-cbl / genetics; Rituximab / administration & dosage; Rituximab / adverse effects
TL;DR: This study developed a strategy to genetically map in vitro drug sensitivity, identifying genes that alter responsiveness to rituximab, a therapeutic anti-CD20 MAb that provides significant benefit to patients with B-cell malignancies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Metabolic network failures in Alzheimer's disease: A biochemical road map

Alzheimers & Dementia, 13(9), 965–984.

By: J. Toledo, M. Arnold, G. Kastenmuller, R. Chang, R. Baillie, X. Han, M. Thambisetty, J. Tenenbaum ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

A comparison of DMET Plus microarray and genome-wide technologies by assessing population substructure

PHARMACOGENETICS AND GENOMICS, 26(4), 147–153.

By: J. Jackson*, K. Long*, Y. He *, A. Motsinger-Reif*, H. McLeod * & J. Jack*

author keywords: admixture; Affymetrix; cryptic relatedness; DMET Plus; inbreeding coefficients; metabolism; pharmacogenomics; population stratification; principal component analysis; transporters
TL;DR: The DMET Plus pharmacogenomics genotyping chip is effective in quantifying population substructure across the three continental populations and inferring the presence of an admixed population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Using ToxCast (TM) data to reconstruct dynamic cell state trajectories and estimate toxicological points of departure

Environmental Health Perspectives, 124(7), 910–919.

By: I. Shah, R. Setzer, J. Jack, K. Houck, R. Judson, T. Knudsen, J. Liu, M. Martin ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Evaluating the role of admixture in cancer therapy via in vitro drug response and multivariate genome-wide associations

PHARMACOGENOMICS, 16(13), 1451–1463.

By: J. Jack n, T. Havener *, H. McLeod *, A. Motsinger-Reif n & M. Foster *

author keywords: admixture; cancer; Caucasian; cytotoxicity; drug; genome-wide association study; GWAS; hispanic; in vitro; lymphoblastoid cell lines
MeSH headings : Black or African American; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cell Line, Tumor; Cohort Studies; Ethnicity; Genetic Variation; Genome-Wide Association Study; Hispanic or Latino; Humans; Multivariate Analysis; Neoplasms / drug therapy; Neoplasms / genetics; Pharmacogenetics; Treatment Outcome; White People
TL;DR: For many drugs, the variability in drug response appears to correlate with self-reported race and estimates of genetic ancestry, and multivariate genome-wide association analyses offered interesting hypotheses governing these differential responses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Population-Based in Vitro Hazard and Concentration-Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study

ENVIRONMENTAL HEALTH PERSPECTIVES, 123(5), 458–466.

By: N. Abdo *, M. Xia *, C. Brown n, O. Kosyk *, R. Huang *, S. Sakamuru *, Y. Zhou n, J. Jack n ...

MeSH headings : Cell Line, Tumor; Genome-Wide Association Study / methods; Genotype; Humans; Risk Assessment; Toxicity Tests / methods
TL;DR: This experimental approach fills critical gaps unaddressed by recent large-scale toxicity testing programs, providing quantitative, experimentally based estimates of human toxicodynamic variability, and also testable hypotheses about mechanisms contributing to interindividual variation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

An adaptive permutation approach for genome-wide association study: Evaluation and recommendations for use

Biodata Mining, 7.

By: R. Che, J. Jack, A. Motsinger-Reif & C. Brown

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Genetic heterogeneity beyond CYP2C8*3 does not explain differential sensitivity to paclitaxel-induced neuropathy

BREAST CANCER RESEARCH AND TREATMENT, 145(1), 245–254.

By: D. Hertz *, S. Roy n, J. Jack n, A. Motsinger-Reif n, A. Drobish*, L. Clark*, L. Carey *, E. Dees *, H. McLeod *

author keywords: Paclitaxel; Pharmacogenetics; Breast cancer; Chemotherapy-induced peripheral neuropathy; ABCG1; Affymetrix DMET (TM) plus; CYP2C8; Race
TL;DR: The pharmacogenetic heterogeneity within a cohort of breast cancer patients is dramatic, though it is not found evidence that this heterogeneity directly influences the risk of PIPN beyond the contribution of CYP2C8*3. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines

PHARMACOGENOMICS, 15(2), 137–146.

By: C. Brown n, T. Havener *, M. Medina, J. Jack n, R. Krauss, H. McLeod *, A. Motsinger-Reif n

author keywords: chemotherapeutics; genome-wide association study; lymphoblastoid cell lines
MeSH headings : Antineoplastic Agents / administration & dosage; Biomarkers, Pharmacological / metabolism; Cell Line, Tumor; Chromosome Mapping; Genome-Wide Association Study; Genotype; Histone Deacetylases / genetics; Humans; Pharmacogenetics; Repressor Proteins / genetics
TL;DR: The utility of LCLs is demonstrated in identifying genes that have clinical importance in drug response and for assigning unclassified agents to specific drug families, and proposes new candidate genes for follow-up in a large number of chemotherapy drugs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Lymphoblastoid Cell Lines Models of Drug Response: Successes and Lessons from this Pharmacogenomic Model

CURRENT MOLECULAR MEDICINE, 14(7), 833–840.

By: J. Jack*, D. Rotroff* & A. Motsinger-Reif*

author keywords: Cytotoxics; genetic association mapping; genome wide association analysis; lymphoplastoid cell lines; pharmacogenomics
MeSH headings : Cell Line, Transformed; Cost-Benefit Analysis; Genome-Wide Association Study / economics; Genome-Wide Association Study / methods; Humans; Lymphocytes / drug effects; Lymphocytes / metabolism; Models, Biological; Models, Genetic; Pharmacogenetics / economics; Pharmacogenetics / methods; Polymorphism, Single Nucleotide; RNA Interference; Reproducibility of Results; Translational Research, Biomedical / economics; Translational Research, Biomedical / methods
TL;DR: The advantages, limitations, and opportunities for using lymphoblastoid cell lines (LCL) as a model system for human pharmacogenomic studies, including multivariate concentration response modeling, issues with multiple testing, and successful examples of the 'triangle model' to identify candidate variants are reviewed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Natural variation in genome architecture among 205 Drosophila melanogaster Genetic Reference Panel lines

Genome Research, 24(7), 1193–1208.

By: W. Huang, A. Massouras, Y. Inoue, J. Peiffer, M. Ramia, A. Tarone, L. Turlapati, T. Zichner ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

PGxClean: a quality control GUI for the Affymetrix DMET chip and other candidate gene studies with non-biallelic alleles

Biodata Mining, 7.

By: D. Rotroff, J. Jack, N. Campbell, S. Clark & A. Motsinger-Reif

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Single-Nucleotide Polymorphism Data Support the General Unrelatedness of the Males in the Agricultural Health Study

Cancer Epidemiology Biomarkers & Prevention, 23(10), 2192–2195.

By: J. Jack n, A. Motsinger-Reif n, S. Koutros *, M. Alavanja*, L. Beane Freeman * & J. Hoppin n 

MeSH headings : Agriculture; Case-Control Studies; Cohort Studies; Consanguinity; Gene-Environment Interaction; Humans; Male; Occupational Exposure; Polymorphism, Single Nucleotide; Principal Component Analysis; Research Design
TL;DR: This analysis rejects the hypothesis that individuals in the case–control study of prostate cancer exhibit cryptic relatedness, and these findings are important for all subsequent analyses of gene–environment interactions in the AHS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

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