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Works (23)
Updated: April 4th, 2024 22:03
2022 article
The impact of undernutrition on KNDy (kisspeptin/neurokinin B/dynorphin) neurons in female lambs
Harlow, K. L., Griesgraber, M. J., Seman, A. D., Shuping, S. L., Sommer, J. R., Griffith, E. H., … Nestor, C. C. (2022, May 17). JOURNAL OF NEUROENDOCRINOLOGY, Vol. 34.
author keywords: dynorphin; kisspeptin; LH; neurokinin B; undernutrition; xxxx; fx1
MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / metabolism; Body Weight; Dynorphins / metabolism; Female; Gonadotropin-Releasing Hormone / metabolism; Kisspeptins / metabolism; Malnutrition / metabolism; Neurokinin B / metabolism; Neurons / metabolism; RNA, Messenger / metabolism; Sheep
TL;DR:
The idea that KNDy neurons are important for regulating reproduction during undernutrition in female sheep is supported, as lower mRNA abundance for kisspeptin within K NDy neurons of FR lambs compared to controls with no significant change in mRNA for NKB or dynorphin is observed.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 14, 2022
2021 journal article
Evidence That Agouti-Related Peptide May Directly Regulate Kisspeptin Neurons in Male Sheep
METABOLITES, 11(3).
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021
2021 journal article
Evidence that pubertal status impacts kisspeptin/neurokinin B/dynorphin neurons in the gilt(dagger)
BIOLOGY OF REPRODUCTION, 105(6), 1533–1544.
author keywords: kisspeptin; NKB; dynorphin; swine; puberty
MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / metabolism; Dynorphins / metabolism; Female; Kisspeptins / metabolism; Neurokinin B / metabolism; Neurons / physiology; Sexual Maturation; Sus scrofa / physiology
TL;DR:
The degree to which KNDy neurons exist in the gilt is characterized for the first time, and the impact of pubertal status on kisspeptin, neurokinin B, and dynorphin in the arcuate nucleus of gilts is examined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 18, 2022
2020 article
Effects of genetic selection for early puberty on the hypothalamic-pituitary-ovarian axis in gilts
Harlow, K. L., Renwick, A., Shuping, S., Sommer, J., Knauer, M., & Nestor, C. (2020, November). JOURNAL OF ANIMAL SCIENCE, Vol. 98, pp. 212–212.
author keywords: puberty; gilt; neuroendocrine
TL;DR:
It is concluded that gilts genetically selected for early puberty do so via changes within the hypothalamus that increase gonadotropin secretion and, in turn, stimulate ovarian growth to ultimately advance the timing of puberty onset.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 8, 2021
2020 article
miRNAs explain the variation in muscle and blood transcriptomes of beef calves born from dams with or without energy restriction during late gestation
Carvalho, E. B., Sanglard, L. P., Nascimento, M., Moriel, P., Sommer, J., Merrill, M., … Serao, N. (2020, November). JOURNAL OF ANIMAL SCIENCE, Vol. 98, pp. 165–165.
author keywords: Fetal-programming; maternal nutrition; post-transcriptional regulation
TL;DR:
Using RNA-seq data, a large amount of the variation of DEGs was identified, with the identification of important miRNAs related to muscle development and immune system and MiR-21 regulates immune system by different pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 8, 2021
2019 article
Genes and functions associated with tolerance to fescue toxicosis in Angus cows
Khanal, P., Sanglard, L. P., Mayberry, K., Sommer, J., Poore, M. H., Poole, D. H., & Serao, N. V. L. (2019, July). JOURNAL OF ANIMAL SCIENCE, Vol. 97, pp. 167–167.
author keywords: fescue toxicosis; differentially expressed genes; tolerance
TL;DR:
Enrichment analysis showed that DEG between genetic groups have general functions, such as metabolic, biosynthetic, and catabolic processes, as well as DNA and RNA-related functions,such as translation, transcription, and repair.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 12, 2019
2018 journal article
High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism
Proceedings of the National Academy of Sciences, 115(21), 5420–5425.
author keywords: HMGA2; dwarfism; swine; gene editing; organ size
MeSH headings : Animals; Cryptorchidism / etiology; Cryptorchidism / pathology; Dwarfism / etiology; Dwarfism / pathology; Female; Fetal Diseases / etiology; Fetal Diseases / pathology; Genotype; HMGA2 Protein / deficiency; HMGA2 Protein / genetics; Litter Size; Male; Nuclear Transfer Techniques / veterinary; Pregnancy; Reproduction; Swine; Swine Diseases / etiology; Swine Diseases / pathology
TL;DR:
The results show that the effect of HMGA2 with respect to growth regulation is highly conserved among mammals and opens up the possibility of regulating body and organ size in a variety of mammalian species including food and companion animals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2018 journal article
Impact of energy restriction during late gestation on the muscle and blood transcriptome of beef calves after preconditioning
BMC Genomics, 19(1).
author keywords: RNA-seq; Fetal development; Fetal programming; Gene expression
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Cattle / blood; Cattle / genetics; Cattle / growth & development; Cattle / metabolism; Female; Gene Regulatory Networks; Male; Muscle, Skeletal / metabolism; Pregnancy; Transcriptome
TL;DR:
In conclusion, maternal energy restriction during late gestation may limit the expression of genes in the muscle and increase expression in the blood of calves and alterations in the intra-uterine environment can modify prenatal development with lasting consequences to adult life.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
5. Gender Equality
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: October 16, 2018
2017 journal article
Supplementation of Maternal Diets with Docosahexaenoic Acid and Methylating Vitamins Impacts Growth and Development of Fetuses from Malnourished Gilts
Current Developments in Nutrition, 2(3).
Contributors: H. Lima n, X. Lin n, S. Jacobi n, C. Man n, n, W. Flowers n , A. Blikslager n , L. Gonzalez n , J. Odle n
author keywords: choline; B-vitamins; epigenetics; intrauterine growth restriction; nutrient restriction; low birth weight
TL;DR:
Despite the mobilization of maternal stores, malnourished litters displayed reduced brain development that was fully mitigated by micronutrient supplementation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
Effect of Plant Species, Fertilizer Acidity/Basicity, and Fertilizer Concentration on pH of Soilless Root Substrate
HORTSCIENCE, 51(12), 1596–1601.
author keywords: alkalinity; electrical conductivity; root media
UN Sustainable Development Goal Categories
2. Zero Hunger
(Web of Science)
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Cloning, characterization, and expression analysis of the pig (Sus scrofa) C1q tumor necrosis factor-related protein-5 gene
Molecular Vision, 18(12-14), 92–102.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Phenotypic stability of Pro347Leu rhodopsin transgenic pigs as indicated by photoreceptor cell degeneration
TRANSGENIC RESEARCH, 20(6), 1391–1395.
author keywords: Transgenic; Pig; Rhodopsin; Phenotype
MeSH headings : Age Factors; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Eosine Yellowish-(YS) / metabolism; Eye / pathology; Female; Hematoxylin / metabolism; Inbreeding; Inheritance Patterns; Male; Phenotype; Photoreceptor Cells, Vertebrate / metabolism; Photoreceptor Cells, Vertebrate / pathology; Retina / metabolism; Retina / pathology; Retinal Degeneration / pathology; Rhodopsin / genetics; Rhodopsin / metabolism; Staining and Labeling; Swine / genetics; Swine / metabolism; Transgenes
TL;DR:
The phenotype, based on assessment of photoreceptor degeneration, is similar to that of the first description of the transgenic animals and can be used confidently in future studies of the type of retinal degeneration seen with retinitis pigmentosa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration
British Journal of Ophthalmology, 95(12), 1749–1754.
MeSH headings : Animals; Animals, Genetically Modified; Disease Models, Animal; Electroretinography; Eye Proteins / biosynthesis; Eye Proteins / genetics; Gene Deletion; Immunohistochemistry; Macular Degeneration / metabolism; Macular Degeneration / pathology; Macular Degeneration / physiopathology; Membrane Proteins / biosynthesis; Membrane Proteins / genetics; Microscopy, Fluorescence; Mutation; Retina / metabolism; Retina / pathology; Retina / physiopathology; Swine
TL;DR:
These transgenic pigs provide unique animal models for examining macular degeneration and STGD3 pathogenesis and direct fluorescence microscopy indicated that the Y270terEYFP protein is expressed in photoreceptors and mislocalised within the cell.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2011 journal article
Transgenic Stra8-EYFP pigs: a model for developing male germ cell technologies
TRANSGENIC RESEARCH, 21(2), 383–392.
author keywords: Pig; Transgenic; Stra8; Spermatogonia; Marker gene
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Animals, Genetically Modified / genetics; Animals, Genetically Modified / metabolism; Blotting, Western; Cells, Cultured; Cloning, Molecular; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Expression Regulation, Developmental; Genes, Reporter; Germ Cells / cytology; Germ Cells / metabolism; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Immunohistochemistry; Luminescent Proteins / genetics; Luminescent Proteins / metabolism; Male; Mice; Microscopy, Fluorescence / methods; Mitochondria / genetics; Mitochondria / metabolism; Nuclear Transfer Techniques; Plasmids / genetics; Plasmids / metabolism; Promoter Regions, Genetic; Proteins / genetics; Proteins / metabolism; Swine; Testis / cytology; Testis / metabolism; Transfection; Transgenes; Tretinoin / pharmacology
TL;DR:
Transgenic pigs expressing mitochondrial localized enhanced yellow fluorescent protein (EYFP-mito) under control of the germ cell specific Stimulated by Retinoic Acid 8 (Stra8) promoter indicates that these pigs will be useful by providing labelled cells for use in such technologies such as germ cell transplantation and in vitro spermatogenic studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Identification of a Promoter for the Human C1q-Tumor Necrosis Factor-Related Protein-5 Gene Associated with Late-Onset Retinal Degeneration
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 51(11), 5499–5507.
MeSH headings : 3' Untranslated Regions / genetics; Animals; Base Sequence; Blotting, Western; Cell Line; Collagen / genetics; Fluorescent Antibody Technique, Indirect; Gene Amplification; Gene Expression Regulation / physiology; Humans; Membrane Proteins / genetics; Molecular Sequence Data; Plasmids; Promoter Regions, Genetic / genetics; Retinal Degeneration / genetics; Retinal Pigment Epithelium / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Transfection
TL;DR:
This study revealed the presence of a functional promoter for the CTRP5 gene located 5' of its start site, and the predicted hCTRP5 promoter was found to control the expression of V5-tagged pCT RP5 and nuclear GFP, indicating that the promoter was functional.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 article
Successful cloning of the Yucatan minipig using commercial/occidental breeds as oocyte donors and embryo recipients
Estrada, J. L., Collins, B., York, A., Bischoff, S., Sommer, J., Tsai, S., … Piedrahita, J. A. (2008, June). CLONING AND STEM CELLS, Vol. 10, pp. 287–296.
MeSH headings : Animals; Cell Line; Cloning, Organism / methods; Fibroblasts / cytology; Microsatellite Repeats; Nuclear Transfer Techniques; Oocytes / physiology; Sus scrofa; Swine; Swine, Miniature / embryology
TL;DR:
This report shows that it is possible to produce viable Yucatan SCNT clones and opens up the possibility of developing valuable biomedical models in this porcine breed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2007 journal article
Swine generated by somatic cell nuclear transfer have increased incidence of intrauterine growth restriction (IUGR)
CLONING AND STEM CELLS, 9(2), 229–236.
MeSH headings : Animals; Birth Weight / physiology; Fetal Growth Retardation; Insemination, Artificial; Litter Size / physiology; Nuclear Transfer Techniques; Swine
TL;DR:
SCNT-derived pigs are excellent models to study epigenetic factors and genes involved in IUGRs, and to develop effective means to improve fetal growth in humans and animals, and there are some differences between SCNT- derived and AI litters.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
Reporter system for the detection of in vivo gene conversion - Changing colors from blue to green using GFP variants
MOLECULAR BIOTECHNOLOGY, 33(2), 115–121.
author keywords: gene conversion; marker; GFP; BFP; oligonucleotide; phosphorothioated; transfection
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; CHO Cells; Clone Cells; Color; Cricetinae; Cricetulus; Gene Conversion / genetics; Genes, Reporter; Genetic Techniques; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Luminescent Proteins / chemistry; Luminescent Proteins / genetics; Molecular Sequence Data; Mutation / genetics; Oligonucleotides / genetics; Plasmids / genetics; Transfection
TL;DR:
A thio-protected single-stranded oligonucleotide designed to convert the genotype of the blue variant to that of the EGFP variant by the correction of a single base pair was delivered to the reported cells using a variety of methodologies and strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Synchronization and superovulation of mature cycling gilts for the collection of pronuclear stage embryos
ANIMAL REPRODUCTION SCIENCE, 100(3-4), 402–410.
author keywords: gilt; superovulation; estrous synchronization; pronuclear stage embryo; PG600 (R); prostaglandin F-2 alpha; transgenic
MeSH headings : Animals; Chorionic Gonadotropin / pharmacology; Dinoprost / analogs & derivatives; Dinoprost / pharmacology; Embryo, Mammalian; Estrous Cycle; Estrus Synchronization / methods; Female; Superovulation / drug effects; Superovulation / physiology; Swine / physiology
TL;DR:
An efficient protocol to synchronize and superovulate mature pigs for the collection of pronuclear stage embryos suitable for DNA microinjection and Pigs 10-16 days after the beginning of standing estrus have been successfully synchronized into estrus using this protocol.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Conditional induction of ovulation in mice
BIOLOGY OF REPRODUCTION, 73(4), 681–687.
author keywords: assisted reproductive technology; anterior pituitary; follicle-stimulating hormone; gene regulation; ovulation
MeSH headings : Animals; Cells, Cultured; Doxycycline / pharmacology; Female; Follicle Stimulating Hormone / blood; Follicle Stimulating Hormone / genetics; Follicle Stimulating Hormone, beta Subunit / genetics; Follicle Stimulating Hormone, beta Subunit / metabolism; Genetic Engineering / methods; Male; Mice; Mice, Transgenic; Ovary / drug effects; Ovary / physiology; Ovulation / drug effects; Ovulation / genetics; Ovulation / physiology; Ovulation Induction / methods; Superovulation / genetics
TL;DR:
In summary, gene switch technology and normal FSH regulation were combined to effectively enhance ovulation in mice and the same strategy can be used with any genetic switch to increase ovulation (or any highly conserved physiology) in any mammal.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Conservation and regeneration of transgenic lines of swine by semen cryopreservation and artificial insemination
Lab Animal, 31(1), 25–31.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Transgenic animals as models for human disease
TRANSGENIC RESEARCH, 9(4-5), 347–351.
author keywords: transgenic animals; models of disease; homologous recombination
MeSH headings : Animals; Animals, Genetically Modified / genetics; Disease Models, Animal; Genetic Techniques; Genetic Vectors; Humans
TL;DR:
The current level and complexity of inquiry using transgenic animals is documented to study the pathological mechanisms behind the disease rather than to just provide a model of the disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa
NATURE BIOTECHNOLOGY, 15(10), 965–970.
author keywords: transgenic swine; retinal degeneration; rhodopsin mutation; night blindness; eye disease
MeSH headings : Animals; Animals, Genetically Modified; Blotting, Southern; Disease Models, Animal; Electroretinography; Embryo Transfer; Gene Expression Regulation / genetics; Genetic Engineering; Microscopy, Electron; Molecular Sequence Data; Phenotype; Polymerase Chain Reaction; Retina / pathology; Retina / physiopathology; Retina / ultrastructure; Retinal Cone Photoreceptor Cells / physiopathology; Retinal Cone Photoreceptor Cells / ultrastructure; Retinal Degeneration / physiopathology; Retinitis Pigmentosa / genetics; Retinitis Pigmentosa / physiopathology; Rhodopsin / chemistry; Rhodopsin / genetics; Swine / embryology; Swine / genetics; Transgenes
TL;DR:
These transgenic pigs that express a mutated rhodopsin gene will provide a large animal model for study of the protracted phase of cone degeneration found in RP and for preclinical treatment trials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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