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Works (29)
Updated: April 4th, 2024 21:54
2021 journal article
Stability of BSE infectivity towards heat treatment even after proteolytic removal of prion protein
VETERINARY RESEARCH, 52(1).
author keywords: Prion; PrP; Molecular mechanism; BSE; Zoonotic; Infectivity; Strain; Heat; Inactivation; Bioassay
MeSH headings : Animals; Bacillus licheniformis / chemistry; Bacillus licheniformis / enzymology; Cattle; Encephalopathy, Bovine Spongiform / etiology; Hot Temperature; Mice, Transgenic; Peptide Hydrolases / metabolism; Prion Proteins / chemistry; Proteolysis
TL;DR:
Findings show the unusual heat resistance of BSE and support a role for an additional factor in prion formation as suggested elsewhere when producing prions from PrP C .
(via Semantic Scholar)
veterinaryresearch.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 3, 2021
2020 journal article
Thermophilic solid state anaerobic digestion of switchgrass for liquid digestate reuse and organic fertilizer production
RENEWABLE AGRICULTURE AND FOOD SYSTEMS, 35(5), 503–512.
author keywords: Biogas; liquid digestate; organic fertilizer; reuse; solid state anaerobic co-digestion; switchgrass
UN Sustainable Development Goal Categories
12. Responsible Consumption and Production
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 21, 2020
2012 journal article
From biogas energy, biotechnology to new agriculture
WORLDS POULTRY SCIENCE JOURNAL, 68(3), 409–416.
author keywords: biogas energy; anaerobic digestion; keratinase; feed enzyme; agriculture
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Evaluation of keratinase stability in pelleted broiler diets
JOURNAL OF APPLIED POULTRY RESEARCH, 18(1), 30–33.
author keywords: pelleting; dietary protein; protease; keratinase
TL;DR:
Versazyme (VZ) is an approved keratinase-based feed additive produced naturally as a fermentation product of Bacillus licheniformis PWD-1 and growth performance results indicate that pelleting did not affect the efficacy of VZ.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Effects of dietary supplementation of keratinase on growth performance, nitrogen retention and intestinal morphology of broiler chickens fed diets with soybean and cottonseed meals
ANIMAL FEED SCIENCE AND TECHNOLOGY, 140(3-4), 376–384.
author keywords: keratinase; broiler performance; nitrogen retention; intestinal morphology
TL;DR:
Dietary supplementation of keratinase increased body weight gain, improved feed conversion ratio and enhanced nitrogen retention in broiler chickens, and boosted growth performance, nutrient digestibility and intestinal development.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Sup35NM-His6 aggregates: A prion-like protein useful in prion degradation studies
ENZYME AND MICROBIAL TECHNOLOGY, 40(4), 976–981.
author keywords: yeast prion; Sup35NM-His6 proteases; prion degradation
TL;DR:
It is suggested that Sup35NM-His6 could be a useful tool to assess the effectiveness of prion degradation for the prevention of TSE.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Beneficial effects of versazyme, a keratinase feed additive, on body weight, feed conversion, and breast yield of broiler chickens
JOURNAL OF APPLIED POULTRY RESEARCH, 15(4), 544–550.
author keywords: broiler; breast meat; dietary protein; protease; keratinase
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Keratinase technology: from feather degradation and feed additive,to prion destruction
CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, 1(042), 6.
Source: NC State University Libraries
Added: August 6, 2018
2005 journal article
Characterization and enzymatic degradation of Sup35NM, a yeast prion-like protein
PROTEIN SCIENCE, 14(9), 2228–2235.
author keywords: BSE; prion; PrPSc; Sup35NM; yeast prion; prion surrogate protein; enzymatic degradation
MeSH headings : Amino Acid Sequence; Blotting, Western; Congo Red / metabolism; Endopeptidase K / metabolism; Escherichia coli / genetics; Fluorescence; Microscopy, Electron / methods; Molecular Sequence Data; Peptide Fragments / chemistry; Peptide Fragments / isolation & purification; Peptide Fragments / metabolism; Peptide Hydrolases / metabolism; Peptide Termination Factors; Prions / chemistry; Prions / isolation & purification; Prions / metabolism; Saccharomyces cerevisiae Proteins / chemistry; Saccharomyces cerevisiae Proteins / isolation & purification; Saccharomyces cerevisiae Proteins / metabolism; Temperature; Time Factors
TL;DR:
The degradation of Sup35NM aggregates by keratinase and proteinase K under various conditions was studied and compared and will be of value in understanding the mechanism and optimization of the degradation process.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Development of an asporogenic Bacillus licheniformis for the production of keratinase
JOURNAL OF APPLIED MICROBIOLOGY, 98(3), 761–767.
author keywords: asporogenic Bacillus; Bacillus licheniformis; keratinase
MeSH headings : Bacillus / genetics; Bacillus / metabolism; Bacillus / physiology; Bioreactors; Genes, Bacterial; Genetic Engineering; Hot Temperature; Industrial Microbiology; Microscopy, Electron; Peptide Hydrolases / biosynthesis; Polymerase Chain Reaction; Spores, Bacterial
TL;DR:
B. licheniformis PWD‐1 is a keratin‐degrading, spore‐forming bacterium isolated from a poultry waste digester and a sporulation‐deficient mutant of B. lichensiformis WBG was developed and characterized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Enzymatic degradation of a prion-like protein, Sup35NM-His6
ENZYME AND MICROBIAL TECHNOLOGY, 36(5-6), 758–765.
author keywords: yeast prion; Sup35p; Sup35NM; proteases; bovine spongiform encephalopathy
TL;DR:
Results indicated that Sup35NM-His6, being simple and inexpensive to produce and non-pathogenic, can be a potential ideal candidate of prion surrogate protein in the study of PrP Sc prion inactivation and prevention of prions diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Versazyme supplementation of broiler diets improves market growth performance
POULTRY SCIENCE, 84(6), 858–864.
author keywords: market weight; growth performance; broiler; diet; enzyme supplementation
MeSH headings : Amino Acids / administration & dosage; Animal Nutritional Physiological Phenomena; Animals; Bacillus / enzymology; Body Weight; Chickens / growth & development; Diet; Dietary Supplements; Male; Peptide Hydrolases / administration & dosage; Soybeans; Zea mays
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Extracellular production of a functional soy cystatin by Bacillus subtilis
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 52(16), 5052–5056.
author keywords: protease inhibitor; cloning; signal peptide; secretion; surimi
MeSH headings : Bacillus subtilis / genetics; Cloning, Molecular; Cystatins / biosynthesis; Cystatins / genetics; Cystatins / metabolism; Escherichia coli / genetics; Glucose / pharmacology; Recombinant Proteins; Soybeans / chemistry; Soybeans / genetics; Transfection
TL;DR:
A recombinant Bacillus subtilis producing soy cystatin was developed by subcloning with a soy cysteine protease gene cloned in Escherichia coli and two gene fragments of signal peptides from kerA and sacB were introduced and compared for secretion efficiency of Cystatin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Increased production of Bacillus keratinase by chromosomal integration of multiple copies of the kerA gene
BIOTECHNOLOGY AND BIOENGINEERING, 87(4), 459–464.
author keywords: keratinase; chromosomal integration; hyperproduction; Bacillus licheniformis
MeSH headings : Bacillus / enzymology; Bacillus / genetics; Bacillus subtilis / enzymology; Bacillus subtilis / genetics; Cell Proliferation; Chromosomes, Bacterial / genetics; Cloning, Molecular; Enzyme Activation; Gene Dosage; Gene Expression Regulation, Bacterial / physiology; Gene Expression Regulation, Enzymologic / physiology; Genetic Enhancement / methods; Mutagenesis, Site-Directed / genetics; Peptide Hydrolases / biosynthesis; Peptide Hydrolases / chemistry; Peptide Hydrolases / genetics; Promoter Regions, Genetic; Protein Engineering / methods; Recombinant Proteins / metabolism; Substrate Specificity
TL;DR:
The strong constitutive promoter P43 not only increased the keratinase production in plasmid‐based expression in DB104 but also improved the enzyme yield of the integrants of T399D.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Bioimmobilization of keratinase using Bacillus subtilis and Escherichia coli systems
BIOTECHNOLOGY AND BIOENGINEERING, 81(4), 421–429.
author keywords: keratinase; immobilization; streptavidin; fusion protein
MeSH headings : Bacillus subtilis / classification; Bacillus subtilis / enzymology; Bacillus subtilis / genetics; Cells, Cultured; Enzymes, Immobilized / chemical synthesis; Enzymes, Immobilized / genetics; Enzymes, Immobilized / isolation & purification; Enzymes, Immobilized / metabolism; Escherichia coli / classification; Escherichia coli / enzymology; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Macromolecular Substances; Peptide Hydrolases / classification; Peptide Hydrolases / genetics; Peptide Hydrolases / isolation & purification; Peptide Hydrolases / metabolism; Protein Binding; Protein Engineering / methods; Recombinant Fusion Proteins / biosynthesis; Recombinant Fusion Proteins / genetics; Species Specificity; Streptavidin / biosynthesis; Streptavidin / classification; Streptavidin / genetics; Streptavidin / isolation & purification
TL;DR:
A new genetic construct was developed to produce the keratinase-streptavidin fusion protein, so that the purification and immobilization of the fusion protein onto a biotinylated matrix can be accomplished in a single step.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Enzymatic degradation of prion protein in brain stem from infected cattle and sheep
JOURNAL OF INFECTIOUS DISEASES, 188(11), 1782–1789.
MeSH headings : Animals; Brain Stem / metabolism; Cattle; Decontamination; Peptide Hydrolases / metabolism; Prion Diseases / metabolism; Prions / metabolism; Protein Denaturation; Sheep; Temperature
TL;DR:
Results indicated that only in the presence of detergents did heat pretreatment at >100 degrees C allow the extensive enzymatic breakdown of PrPSc to a state where it is immunochemically undetectable, which could lead to the development of a method for the decontamination of medical and laboratory equipment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Keratinase in starter diets improves growth of broiler chicks
POULTRY SCIENCE, 82(4), 664–670.
author keywords: broiler; protease; keratinase; growth performance; starter feed
MeSH headings : Age Factors; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Body Weight / drug effects; Chickens / growth & development; Digestive System / chemistry; Dose-Response Relationship, Drug; Female; Male; Peptide Hydrolases / administration & dosage; Peptide Hydrolases / pharmacology; Random Allocation; Soybeans; Viscosity; Weight Gain / drug effects; Zea mays
TL;DR:
Results of these experiments indicate that the growth of broiler chickens can be significantly improved by dietary supplementation with PWD-1 keratinase.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Production and characterization of bio-immobilized keratinase in proteolysis and keratinolysis
ENZYME AND MICROBIAL TECHNOLOGY, 32(7), 812–819.
author keywords: keratinase; bio-immobililzation; streptavidin; fusion protein
TL;DR:
Extracellular production of keratinase–streptavidin fusion protein was accomplished by the cloning of Bacillus subtilis with a transforming plasmid carrying the kerA - stp fusion gene.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2001 article
Dr Milton L. Scott: A remembrance
World's Poultry Science Journal, Vol. 57, pp. 465–466.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Fermentation production of keratinase from Bacillus licheniformis PWD-1 and a recombinant B-subtilis FDB-29
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 22(6), 608–616.
author keywords: keratinase production; fermentation; Bacillus; recombinant strain
TL;DR:
After respective optimization of fermentation conditions, keratinase production by B. licheniformis PWD-1 is approximately 40% higher than thatBy B. subtilis FDB-29, a recombinant strain, and control of pH is not necessary.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
1998 patent
DNA encoding Bacillus lichenformis PWD-1 keratinase
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1997 article
Expression of the Bacillus licheniformis PWD-1 keratinase gene in B-subtilis
Lin, X., Wong, S. L., Miller, E. S., & Shih, J. C. H. (1997, August). JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, Vol. 19, pp. 134–138.
author keywords: keratinase; gene cloning; gene expression; Bacilli
MeSH headings : Bacillus / enzymology; Bacillus subtilis / genetics; Cloning, Molecular; Glucose / pharmacology; Peptide Hydrolases / biosynthesis; Peptide Hydrolases / genetics; Plasmids; Recombinant Proteins / biosynthesis
TL;DR:
The kerA gene which encodes the enzyme keratinase was isolated from the feather-degrading bacterium Bacillus licheniformis PWD-1 and transformants and was further characterized when glucose or casamino acids were supplemented into the feather medium.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1996 patent
Process and apparatus for anaerobic digestion
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1993 patent
Method and composition for maintaining animals on a keratin-containing diet
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1992 patent
Purified Bacillus licheniformis PWD-1 keratinase
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1991 patent
Method of degrading keratinaceous material and bacteria useful therefor
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1990 patent
Feather-lysate, a hydrolyzed feather feed ingredient and animal feeds containing the same
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1990 patent
Method of degrading keratinaceous material and bacteria useful therefore
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1983 journal article
GENETIC SELECTION, GENERAL CHARACTERIZATION, AND HISTOLOGY OF ATHEROSCLEROSIS-SUSCEPTIBLE AND ATHEROSCLEROSIS-RESISTANT JAPANESE QUAIL
ATHEROSCLEROSIS, 49(1), 41–53.
MeSH headings : Animals; Arteriosclerosis / genetics; Arteriosclerosis / pathology; Cholesterol, Dietary / administration & dosage; Coturnix; Disease Models, Animal; Female; Male; Quail; Selection, Genetic
TL;DR:
Characterization of the selected quail has shown that the RES birds were resistant to the disease and developed little atherosclerosis on a diet containing 1% cholesterol, and these two lines of quail may serve as a valid animal model for the study of the genetic and biochemical basis of cholesterol-induced Atherosclerosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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