Works (62)

Updated: February 10th, 2024 05:00

2024 journal article

Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs)

Exposome.

By: M. Chung*, J. House*, F. Akhtari*, K. Makris*, M. Langston*, K. Islam*, P. Holmes*, M. Chadeau-Hyam* ...

co-author countries: China 🇨🇳 Cyprus 🇨🇾 United Kingdom of Great Britain and Northern Ireland 🇬🇧 United States of America 🇺🇸
Source: ORCID
Added: January 26, 2024

2024 journal article

Guided optimization of ToxPi model weights using a Semi-Automated approach

COMPUTATIONAL TOXICOLOGY, 29.

By: J. Fleming n, J. House*, J. Chappel n, A. Motsinger-Reif* & D. Reif*

co-author countries: United States of America 🇺🇸
author keywords: Machine learning; Feature weighting; Exposure assessment; Chemical toxicity; Ordinal regression; Genetic algorithm
Sources: Web Of Science, ORCID
Added: January 16, 2024

2024 article

Interactive data sharing for multiple questionnaire-based exposome-wide association studies and exposome correlations in the Personalized Environment and Genes Study

Lloyd, D., House, J., Akhtari, F., Schmitt, C., Fargo, D., Scholl, E., … Motsinger-Reif, A. (2024, February 9).

By: D. Lloyd, J. House, F. Akhtari, C. Schmitt, D. Fargo, E. Scholl, J. Phillips, S. Choksi ...

Source: ORCID
Added: February 10, 2024

2024 article

Questionnaire-based exposome-wide association studies for common diseases in the Personalized Environment and Genes Study

Lloyd, D., House, J., Akhtari, F., Schmitt, C., Fargo, D., Scholl, E., … Motsinger-Reif, A. (2024, February 9).

By: D. Lloyd, J. House, F. Akhtari, C. Schmitt, D. Fargo, E. Scholl, J. Phillips, S. Choksi ...

Source: ORCID
Added: February 10, 2024

2023 article

A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo

Tsai, H.-H. D., House, J. S., Wright, F. A., Chiu, W. A., & Rusyn, I. (2023, April 20). TOXICOLOGICAL SCIENCES.

By: H. Tsai*, J. House*, F. Wright n, W. Chiu* & I. Rusyn*

co-author countries: United States of America 🇺🇸
author keywords: transcriptomic; petroleum; grouping; dose-response; HTTr; NAMs
MeSH headings : Humans; Transcriptome; Petroleum / toxicity; Endothelial Cells; Gene Expression Profiling; Cell Line
Sources: ORCID, Web Of Science
Added: May 22, 2023

2023 journal article

C/EBP beta deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors

INNATE IMMUNITY, 29(1-2), 14–24.

By: J. House n, S. Gray n, J. Owen n, D. Jima n, R. Smart n & J. Hall n

co-author countries: United States of America 🇺🇸
author keywords: C/EBP beta; cell death; keratinocytes; type I IFN response
MeSH headings : Animals; Mice; Caspase 3 / metabolism; Caspase 8 / metabolism; CCAAT-Enhancer-Binding Protein-beta / genetics; Immunity, Innate; Interferon Type I / metabolism; Keratinocytes; Receptors, Pattern Recognition / genetics; Receptors, Pattern Recognition / metabolism
Sources: Web Of Science, ORCID
Added: May 30, 2023

2023 article

Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Choudhary, P., Monasso, G. S., Karhunen, V., Ronkainen, J., Mancano, G., Howe, C. G., … Sebert, S. (2023, December 5). MOLECULAR PSYCHIATRY, Vol. 12.

By: P. Choudhary*, G. Monasso*, V. Karhunen*, J. Ronkainen*, G. Mancano*, C. Howe*, Z. Niu*, X. Zeng* ...

co-author countries: Australia 🇦🇺 Belgium 🇧🇪 Germany 🇩🇪 Spain 🇪🇸 Finland 🇫🇮 France 🇫🇷 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Greece 🇬🇷 Italy 🇮🇹 Netherlands 🇳🇱 Norway 🇳🇴 Sweden 🇸🇪 United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: January 16, 2024

2023 journal article

Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats

Metabolomics.

co-author countries: Canada 🇨🇦 United States of America 🇺🇸
Source: ORCID
Added: January 26, 2024

2023 journal article

ToxicR: A computational platform in R for computational toxicology and dose–response analyses

Computational Toxicology, 25, 100259.

By: M. Wheeler*, S. Lim*, J. House*, K. Shockley*, A. John Bailer*, J. Fostel, L. Yang, D. Talley ...

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: April 12, 2023

2022 journal article

143-OR: Mapping Genetic Determinants of Blood Glucose Control in the Action to Control Cardiovascular Risk in Diabetes Study Group (ACCORD)

Diabetes, 71(Supplement_1).

By: J. House*, D. Rotroff, V. Fonseca, J. Hempe, J. Mychaleckyj, A. Doria, J. Buse, A. Motsinger Reif

Sources: Crossref, ORCID
Added: April 21, 2023

2022 journal article

Abstract PR011: Characterization of the precancerous and cancer microenvironment in a zebrafish sarcoma model

Clinical Cancer Research, 28(18_Supplement), PR011–PR011.

By: H. Shive*, J. House*, J. Ferguson n, D. Jima n, A. Selmek* & D. Lloyd n

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: April 12, 2023

2022 journal article

Adrenal Stress Hormone Regulation of Hepatic Homeostatic Function After an Acute Ozone Exposure in Wistar-Kyoto Male Rats

Toxicological Sciences, 189(1), 73–90.

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Corticosterone; Homeostasis; Insulin; Male; Ozone / toxicity; RNA, Messenger; Rats; Rats, Inbred WKY
Sources: ORCID, Crossref
Added: April 11, 2023

2022 journal article

Clomifene and Assisted Reproductive Technology in Humans Are Associated with Sex-Specific Offspring Epigenetic Alterations in Imprinted Control Regions

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(18).

co-author countries: United States of America 🇺🇸
author keywords: differentially methylated regions; adverse offspring outcomes; infertility
MeSH headings : Child; Clomiphene; DNA Methylation; Female; Genomic Imprinting; Humans; Male; Reproductive Techniques, Assisted / adverse effects; Retrospective Studies
Sources: Web Of Science, ORCID
Added: October 3, 2022

2022 journal article

Comparison of National Vulnerability Indices Used by the Centers for Disease Control and Prevention for the COVID-19 Response

Public Health Reports, 137(4), 803–812.

co-author countries: United States of America 🇺🇸
author keywords: COVID-19; vulnerability; social vulnerability index; GIS; geographic information systems
MeSH headings : COVID-19 / epidemiology; COVID-19 / prevention & control; Centers for Disease Control and Prevention, U.S.; Humans; Pandemics / prevention & control; Public Health; United States / epidemiology
Sources: Web Of Science, ORCID, Crossref
Added: May 6, 2022

2022 article

Genomic map of candidate human imprint control regions: the imprintome

Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.

By: D. Jima n, D. Skaar n, A. Planchart n, A. Motsinger-Reif n, S. Cevik n, S. Park n, M. Cowley n, F. Wright n ...

co-author countries: United States of America 🇺🇸
author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 journal article

Grouping of UVCB Substances with Dose-Response Transcriptomics Data from Human Cell-Based Assays

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 39(3), 388–404.

By: J. House n, F. Grimm*, W. Klaren*, A. Dalzell*, S. Kuchi*, S. Zhang*, K. Lenz*, P. Boogaard ...

co-author countries: Belgium 🇧🇪 Germany 🇩🇪 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Netherlands 🇳🇱 United States of America 🇺🇸
MeSH headings : Biological Assay; Endothelial Cells; Humans; Induced Pluripotent Stem Cells; Petroleum; Transcriptome
Sources: Web Of Science, ORCID
Added: August 29, 2022

2022 journal article

LBMON114 Enrichment Of Rare Sequence Variants In Genes That Communicate Metabolic Signals To The GnRH System In Hypothalamic Amenorrhea

Journal of the Endocrine Society, 6(Supplement_1), A466–A467.

By: E. Brown, S. Shekhar, A. Delaney, A. Burkholder, L. Plummer, V. Mericq, P. Merino, R. Quinton ...

Sources: Crossref, ORCID
Added: April 12, 2023

2022 journal article

Longitudinal Serological Surveillance for COVID-19 Antibodies after Infection and Vaccination

Microbiology Spectrum, 10(5).

By: C. McGee*, M. Shi*, J. House*, A. Drude*, G. Gonzalez*, N. Martin*, S. Chen*, H. Rogers* ...

co-author countries: United States of America 🇺🇸

Ed(s): O. Laeyendecker

MeSH headings : Humans; COVID-19 / prevention & control; Pandemics; Ad26COVS1; Vaccination; Antibodies; Antibodies, Viral
Sources: Crossref, ORCID
Added: April 12, 2023

2022 journal article

Maternal Mediterranean Diet Adherence and Its Associations with Maternal Prenatal Stressors and Child Growth

CURRENT DEVELOPMENTS IN NUTRITION, 6(11).

By: S. Gonzalez-Nahm*, J. Marchesoni n, A. Maity n, R. Maguire n, J. House*, R. Tucker n, T. Atkinson n, S. Murphy*, C. Hoyo n

co-author countries: United States of America 🇺🇸
author keywords: Mediterranean diet; stressors; child weight; birth outcomes; maternal diet
Sources: Web Of Science, ORCID
Added: February 20, 2023

2022 journal article

Maternal Periconceptional Stressors, Mediterranean Diet Adherence, and Child Outcomes

Current Developments in Nutrition, 6, 650.

By: S. Gonzalez-Nahm*, J. Marchesoni n, A. Maity n, R. Maguire n, J. House*, R. Tucker n, T. Atkinson n, S. Murphy*, C. Hoyo n

co-author countries: United States of America 🇺🇸
Sources: Crossref, ORCID
Added: April 12, 2023

2022 journal article

Questionnaire-Based Polyexposure Assessment Outperforms Polygenic Scores for Classification of Type 2 Diabetes in a Multiancestry Cohort

Diabetes Care, 11, dc220295.

By: F. Akhtari*, D. Lloyd*, A. Burkholder*, X. Tong*, J. House*, E. Lee*, J. Buse*, S. Schurman* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Humans; Diabetes Mellitus, Type 2 / epidemiology; Diabetes Mellitus, Type 2 / genetics; Hypertension / complications; Environmental Exposure; Multifactorial Inheritance / genetics; Surveys and Questionnaires; Genome-Wide Association Study; Risk Factors
Sources: Crossref, ORCID
Added: April 12, 2023

2022 journal article

Questionnaire-based exposome-wide association studies (ExWAS) reveal expected and novel risk factors associated with cardiovascular outcomes in the Personalized Environment and Genes Study

Environmental Research, 212, 113463.

By: E. Lee*, F. Akhtari*, J. House*, R. Simpson*, C. Schmitt*, D. Fargo*, S. Schurman*, J. Hall*, A. Motsinger-Reif*

co-author countries: United States of America 🇺🇸
MeSH headings : Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / etiology; Coronary Artery Disease; Exposome; Heart Failure; Humans; Myocardial Infarction; Risk Factors; Stroke / epidemiology; Surveys and Questionnaires
Sources: ORCID, Crossref
Added: April 11, 2023

2022 journal article

Social isolation exacerbates acute ozone inhalation induced pulmonary and systemic health outcomes

Toxicology and Applied Pharmacology, 457, 116295.

By: A. Henriquez, S. Snow, T. Jackson, J. House*, D. Alewel, M. Schladweiler, M. Valdez, D. Freeborn ...

Sources: Crossref, ORCID
Added: April 12, 2023

2022 journal article

Stress Drivers of Glucose Dynamics during Ozone Exposure Measured Using Radiotelemetry in Rats

Environmental Health Perspectives, 130(12).

By: A. Henriquez*, S. Snow*, T. Jackson*, J. House*, A. Motsinger-Reif*, C. Ward-Caviness*, M. Schladweiler*, D. Alewel* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Rats; Male; Animals; Glucose; Receptors, Glucocorticoid; Blood Glucose Self-Monitoring; Irritants; Blood Glucose; Rats, Inbred WKY; Corticosterone; Ozone / toxicity; Air Pollutants / toxicity; Adrenergic Agents
Sources: Crossref, ORCID
Added: April 12, 2023

2021 journal article

Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome‐Wide Interaction Meta‐Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies

Clinical Pharmacology & Therapeutics, 110(3), 723–732.

By: C. McDonough*, H. Warren*, J. Jack n, A. Motsinger‐Reif*, N. Armstrong*, J. Bis*, J. House*, S. Singh* ...

co-author countries: Canada 🇨🇦 Finland 🇫🇮 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Italy 🇮🇹 United States of America 🇺🇸
MeSH headings : Black or African American / genetics; Aged; Antihypertensive Agents / therapeutic use; Blood Pressure / drug effects; Blood Pressure / genetics; Cardiovascular Diseases / chemically induced; Cardiovascular Diseases / genetics; Cardiovascular System / drug effects; Drug-Related Side Effects and Adverse Reactions / etiology; Drug-Related Side Effects and Adverse Reactions / genetics; Female; Genome-Wide Association Study / methods; Humans; Hypertension / drug therapy; Hypertension / genetics; Male; Middle Aged; Pharmacogenomic Testing / methods; Polymorphism, Single Nucleotide / genetics
Sources: Web Of Science, ORCID, Crossref
Added: August 23, 2021

2021 journal article

Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort

PEDIATRIC OBESITY, 16(7).

By: R. Maguire n, J. House n, D. Lloyd n, H. Skinner n, T. Allen*, A. Raffi n, D. Skaar n, S. Park n ...

co-author countries: United States of America 🇺🇸

Contributors: R. Maguire n, J. House n, D. Lloyd n, H. Skinner n, T. Allen*, A. Raffi n, D. Skaar n, S. Park n ...

author keywords: cytokines; maternal obesity; childhood obesity
MeSH headings : Black or African American; Body Mass Index; Child; Child, Preschool; Cohort Studies; Cytokines / blood; Female; Humans; Obesity, Maternal / epidemiology; Pediatric Obesity / epidemiology; Pregnancy; White People
Sources: Web Of Science, ORCID
Added: January 19, 2021

2021 article

Glucose dynamics during ozone exposure measured using radiotelemetry: Stress drivers

Henriquez, A. R., Snow, S. J., Jackson, T. W., House, J. S., Motsinger-Reif, A. A., Ward-Caviness, C. K., … Kodavanti, U. P. (2021, December 9). (Vol. 12). Vol. 12.

By: A. Henriquez*, S. Snow*, T. Jackson, J. House*, A. Motsinger-Reif*, C. Ward-Caviness*, M. Schladweiler*, D. Alewel* ...

co-author countries: United States of America 🇺🇸
Source: ORCID
Added: April 11, 2023

2021 journal article

Grouping of UVCB Substances with New Approach Methodologies (NAMs) Data

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 38(1), 123–137.

By: J. House n, F. Grimm*, W. Klaren*, A. Dalzell*, S. Kuchi*, S. Zhang*, K. Lenz*, P. Boogaard* ...

co-author countries: Belgium 🇧🇪 Germany 🇩🇪 United Kingdom of Great Britain and Northern Ireland 🇬🇧 Netherlands 🇳🇱 United States of America 🇺🇸

Contributors: J. House n, F. Grimm*, W. Klaren*, A. Dalzell*, S. Kuchi*, S. Zhang*, K. Lenz*, P. Boogaard* ...

MeSH headings : Animal Testing Alternatives / methods; Hazardous Substances / chemistry; Hazardous Substances / toxicity; Humans; Induced Pluripotent Stem Cells / drug effects; Petroleum / analysis; Petroleum / toxicity; Toxicity Tests / methods
Sources: Web Of Science, ORCID
Added: March 15, 2021

2021 journal article

High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs

PLOS GENETICS, 17(8).

By: F. Akhtari n, A. Green n, G. Small*, T. Havener*, J. House*, K. Roell n, D. Reif n, H. McLeod, T. Wiltshire*, A. Motsinger-Reif*

co-author countries: United States of America 🇺🇸

Ed(s): F. Vazquez

MeSH headings : Antineoplastic Agents / pharmacology; Biomarkers, Pharmacological / analysis; Cell Line, Tumor; Genome-Wide Association Study / methods; High-Throughput Screening Assays / methods; Humans; NAD(P)H Dehydrogenase (Quinone) / drug effects; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / metabolism
Sources: Web Of Science, ORCID
Added: August 27, 2021

2021 journal article

Lrp1 regulation of pulmonary function follow-up of human GWAS in mice

American Journal of Respiratory Cell and Molecular Biology, 64(3), 368–378.

By: C. Nichols*, J. House*, H. Li*, J. Ward, A. Wyss, J. Williams*, L. Deterding*, J. Bradbury* ...

co-author countries: France 🇫🇷 United States of America 🇺🇸

Contributors: C. Nichols*, J. House*, H. Li*, J. Ward, A. Wyss, J. Williams*, L. Deterding*, J. Bradbury* ...

MeSH headings : Animals; Bronchoalveolar Lavage Fluid; Genome-Wide Association Study; Humans; Lipopolysaccharides / pharmacology; Low Density Lipoprotein Receptor-Related Protein-1 / metabolism; Lung / physiology; Mice; Muscle, Smooth / drug effects; Muscle, Smooth / metabolism; Polymorphism, Single Nucleotide / genetics; Proteome / metabolism; Pyroglyphidae / physiology; Quantitative Trait Loci / genetics
Source: ORCID
Added: April 11, 2023

2021 journal article

Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST

Nutrients, 13(9), 3180.

co-author countries: United States of America 🇺🇸
MeSH headings : Child Behavior Disorders / etiology; DNA Methylation; Dental Anxiety / etiology; Diet / adverse effects; Dietary Carbohydrates / adverse effects; Female; Glycemic Load / physiology; Humans; Impulsive Behavior; Infant; Infant Behavior; Male; Maternal Nutritional Physiological Phenomena; Pregnancy; Prenatal Exposure Delayed Effects / metabolism; Sex Factors; Temperament
Source: ORCID
Added: April 11, 2023

2021 journal article

Peripheral metabolic effects of ozone exposure in healthy and diabetic rats on normal or high-cholesterol diet

Toxicology and Applied Pharmacology, 415, 115427.

By: S. Snow*, A. Henriquez*, A. Fisher*, B. Vallanat*, J. House*, M. Schladweiler*, C. Wood*, U. Kodavanti*

co-author countries: United States of America 🇺🇸

Contributors: S. Snow*, A. Henriquez*, A. Fisher*, B. Vallanat*, J. House*, M. Schladweiler*, C. Wood*, U. Kodavanti*

MeSH headings : Adipose Tissue, White / drug effects; Adipose Tissue, White / metabolism; Adipose Tissue, White / pathology; Air Pollutants / toxicity; Animals; Biomarkers / blood; Blood Glucose / drug effects; Blood Glucose / metabolism; Body Composition / drug effects; Cholesterol, Dietary / metabolism; Cholesterol, Dietary / toxicity; Diabetes Mellitus, Type 2 / blood; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / genetics; Diet, High-Fat / adverse effects; Disease Models, Animal; Energy Metabolism / drug effects; Gene Expression Regulation; Inhalation Exposure; Insulin / blood; Lipids / blood; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Ozone / toxicity; Rats, Wistar; Species Specificity
Sources: ORCID, Crossref
Added: April 11, 2023

2021 personal communication

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning

Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y.-H., Wright, F. A., … Reif, D. M. (2021, January).

co-author countries: United States of America 🇺🇸

Contributors: S. Marvel n, J. House*, M. Wheeler*, K. Song n, Y. Zhou n, F. Wright n, W. Chiu*, I. Rusyn*, A. Motsinger-Reif*, D. Reif n

MeSH headings : COVID-19 / epidemiology; Data Visualization; Health Status Indicators; Humans; Machine Learning; Models, Statistical; Vulnerable Populations
Sources: Web Of Science, ORCID
Added: March 22, 2021

2021 journal article

The Role of Hepatic Vagal Tone in Ozone-Induced Metabolic Dysfunction in the Liver

Toxicological Sciences, 181(2), 229–245.

By: C. Colonna*, A. Henriquez*, J. House*, A. Motsinger-Reif*, D. Alewel*, A. Fisher*, H. Ren*, S. Snow* ...

co-author countries: United States of America 🇺🇸

Contributors: C. Colonna*, A. Henriquez*, J. House*, A. Motsinger-Reif*, D. Alewel*, A. Fisher*, H. Ren*, S. Snow* ...

MeSH headings : Air Pollutants / toxicity; Animals; Liver; Male; Ozone / toxicity; Rats; Rats, Inbred WKY; Transcriptome
Source: ORCID
Added: April 11, 2023

2020 journal article

Associations between Maternal Cadmium Exposure with Risk of Preterm Birth and Low after Birth Weight Effect of Mediterranean Diet Adherence on Affected Prenatal Outcomes

TOXICS, 8(4).

By: S. Gonzalez-Nahm*, K. Nihlani*, J. S. House*, R. L. Maguire n, H. G. Skinner n & C. Hoyo n

co-author countries: United States of America 🇺🇸

Contributors: S. Gonzalez-Nahm*, K. Nihlani*, J. House*, R. Maguire n, H. Skinner n & C. Hoyo n

author keywords: cadmium; heavy metals; birth weight; preterm birth; diet pattern; Mediterranean diet; pregnancy
Sources: ORCID, Web Of Science
Added: January 19, 2021

2020 journal article

Fibrate pharmacogenomics: Expanding past the genome

Pharmacogenomics, 21(4), 293–306.

By: J. House* & A. Motsinger-Reif*

co-author countries: United States of America 🇺🇸

Contributors: J. House* & A. Motsinger-Reif*

MeSH headings : Cardiovascular Diseases / blood; Cardiovascular Diseases / drug therapy; Cardiovascular Diseases / genetics; Fibric Acids / therapeutic use; Genome / genetics; Genome-Wide Association Study / methods; Humans; Hypolipidemic Agents / therapeutic use; Pharmacogenetics / methods; Polymorphism, Single Nucleotide / genetics; Risk Factors; Triglycerides / blood
Source: ORCID
Added: April 11, 2023

2020 journal article

Low-Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells

SMALL, 16(21).

By: J. House n, E. Bouzos*, K. Fahy*, V. Francisco*, D. Lloyd n, F. Wright n, A. Motsinger-Reif*, P. Asuri*, K. Wheeler*

co-author countries: United States of America 🇺🇸

Contributors: J. House n, E. Bouzos*, K. Fahy*, V. Francisco*, D. Lloyd n, F. Wright n, A. Motsinger-Reif*, P. Asuri*, K. Wheeler*

author keywords: nanotoxicity; silver nanoparticles; transcriptomics
MeSH headings : Gene Expression / drug effects; Hepatocytes / drug effects; Humans; Metal Nanoparticles / chemistry; Silver; Surface Properties; Time Factors
Sources: Web Of Science, ORCID
Added: April 14, 2020

2020 article

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning

MedRxiv, Vol. 8.

By: S. Marvel n, J. House*, M. Wheeler*, K. Song n, Y. Zhou n, F. Wright n, W. Chiu*, I. Rusyn*, A. Motsinger-Reif*, D. Reif n

co-author countries: United States of America 🇺🇸

Contributors: S. Marvel n, J. House*, M. Wheeler*, K. Song n, Y. Zhou n, F. Wright n, W. Chiu*, I. Rusyn*, A. Motsinger-Reif*, D. Reif n

Source: ORCID
Added: August 21, 2020

2020 journal article

Tissue-Engineered Bone Tumor as a Reproducible Human in Vitro Model for Studies of Anticancer Drugs

TOXICOLOGICAL SCIENCES, 173(1), 65–76.

By: C. Sakolish*, J. House n, A. Chramiec*, Y. Liu*, Z. Chen*, S. Halligan*, G. Vunjak-Novakovic*, I. Rusyn*

co-author countries: United States of America 🇺🇸

Contributors: C. Sakolish*, J. House n, A. Chramiec*, Y. Liu*, Z. Chen*, S. Halligan*, G. Vunjak-Novakovic*, I. Rusyn*

author keywords: tissue chip; alternatives to animal testing < in vitro and alternatives; toxicogenomics < methods; safety evaluation; bone < systems toxicology
MeSH headings : Antineoplastic Agents / therapeutic use; Bone Neoplasms / drug therapy; Bone Neoplasms / metabolism; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cisplatin; Doxorubicin; Humans; Imidazoles; Osteoblasts; Pyrazines; Sarcoma, Ewing / drug therapy; Tissue Engineering / methods; Tumor Microenvironment; Vincristine
Sources: Web Of Science, ORCID
Added: February 3, 2020

2019 journal article

C/EBP beta suppresses keratinocyte autonomous type 1 IFN response and p53 to increase cell survival and susceptibility to UVB-induced skin cancer

CARCINOGENESIS, 40(9), 1099–1109.

By: H. Tam n, J. Hall n, Z. Messenger n, D. Jima n, J. House n, K. Linder n, R. Smart n

co-author countries: United States of America 🇺🇸

Contributors: H. Tam n, J. Hall n, Z. Messenger n, D. Jima n, J. House n, K. Linder n, R. Smart n

Sources: Web Of Science, ORCID
Added: November 18, 2019

2019 journal article

Cadmium exposure and MEG3 methylation differences between Whites and African Americans in the NEST Cohort

Environmental Epigenetics, 5(3).

co-author countries: United States of America 🇺🇸

Ed(s): M. Skinner

author keywords: maternal exposures; imprinted genes; offspring epigenetics; cadmium; CpG methylation; racial epigenetic outcome differences
Sources: ORCID, Crossref
Added: September 6, 2019

2019 journal article

Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization

PLOS ONE, 14(10).

co-author countries: United States of America 🇺🇸

Contributors: M. Onel*, B. Beykal*, K. Ferguson*, W. Chiu*, T. McDonald*, L. Zhou*, J. House n, F. Wright n ...

MeSH headings : Chemistry Techniques, Analytical / methods; Gas Chromatography-Mass Spectrometry; Petroleum / analysis; Principal Component Analysis; Reference Standards; Sample Size
Sources: Web Of Science, ORCID
Added: June 1, 2020

2019 journal article

Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 101, 91–102.

By: F. Grimm*, J. House n, M. Wilson*, O. Sirenko*, Y. Iwata*, F. Wright n, N. Ball, I. Rusyn*

co-author countries: United States of America 🇺🇸

Contributors: F. Grimm*, J. House n, M. Wilson*, O. Sirenko*, Y. Iwata*, F. Wright n, N. Ball, I. Rusyn*

author keywords: New assessment methodologies; Glycol ethers; In vitro; ToxPi; Read-across; Safety assessment
MeSH headings : Animals; Cell Line; Ethers / classification; Ethers / toxicity; Glycols / classification; Glycols / toxicity; Humans; Risk Assessment; Solvents / classification; Solvents / toxicity; Toxicity Tests
Sources: Web Of Science, ORCID
Added: April 22, 2019

2019 journal article

Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing

JOURNAL OF CELL BIOLOGY, 218(6), 1994–2005.

By: K. Sai n, C. Parsons n, J. House n, S. Kathariou n & J. Ninomiya-Tsuji n

co-author countries: United States of America 🇺🇸

Contributors: K. Sai n, C. Parsons n, J. House n, S. Kathariou n & J. Ninomiya-Tsuji n

MeSH headings : Animals; Female; Humans; Listeria / growth & development; Listeria / immunology; Listeria / metabolism; Listeriosis / metabolism; Listeriosis / microbiology; Listeriosis / pathology; Listeriosis / prevention & control; Mice; Mice, Inbred C57BL; Mice, Knockout; Necroptosis; Protein Kinases / physiology; Receptor-Interacting Protein Serine-Threonine Kinases / genetics; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Receptor-Interacting Protein Serine-Threonine Kinases / physiology
Sources: Web Of Science, ORCID
Added: June 24, 2019

2019 journal article

Ozone-Induced Dysregulation of Neuroendocrine Axes Requires Adrenal-Derived Stress Hormones

TOXICOLOGICAL SCIENCES, 172(1), 38–50.

co-author countries: Italy 🇮🇹 Japan 🇯🇵 United States of America 🇺🇸
author keywords: ozone; brainstem; hypothalamus; pituitary; adrenalectomy; neuroendocrine hormones
Sources: Web Of Science, ORCID
Added: November 18, 2019

2019 journal article

Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes

Toxicology and Applied Pharmacology, 381.

By: S. Burnett*, A. Blanchette*, F. Grimm*, J. House n, D. Reif n, F. Wright n, W. Chiu*, I. Rusyn*

co-author countries: United States of America 🇺🇸

Contributors: S. Burnett*, A. Blanchette*, F. Grimm*, J. House n, D. Reif n, F. Wright n, W. Chiu*, I. Rusyn*

author keywords: iPSC; In vitro; Alternative methods; Cardiotoxicity; High-content screening; Environmental chemicals
MeSH headings : Calcium / metabolism; Cardiotoxicity; Cells, Cultured; Drug Evaluation, Preclinical / methods; Female; Genotype; Humans; Induced Pluripotent Stem Cells / cytology; Male; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / metabolism; Phenotype; Racial Groups; Toxicity Tests / methods
Source: ORCID
Added: August 30, 2019

2018 journal article

A Human Population-Based Organotypic In Vitro Model for Cardiotoxicity Screening

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 35(4), 441–452.

By: F. Grimm*, A. Blanchette*, J. House n, K. Ferguson*, N. Hsieh*, C. Dalaijamts*, A. Wright*, B. Anson* ...

co-author countries: United States of America 🇺🇸

Contributors: F. Grimm*, A. Blanchette*, J. House n, K. Ferguson*, N. Hsieh*, C. Dalaijamts*, A. Wright*, B. Anson* ...

MeSH headings : Cardiotoxicity / genetics; Cardiovascular Agents / pharmacology; Cardiovascular Agents / toxicity; Cell Differentiation / drug effects; Cell Differentiation / genetics; Female; Healthy Volunteers; Humans; In Vitro Techniques; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / drug effects; Male; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Phenotype; Reproducibility of Results
Sources: Web Of Science, ORCID
Added: December 10, 2018

2018 journal article

C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event

Cell Death & Disease, 9(11).

By: Z. Messenger*, J. Hall*, D. Jima*, J. House*, H. Tam, D. Tokarz n, R. Smart*

co-author countries: United States of America 🇺🇸

Contributors: Z. Messenger*, J. Hall*, D. Jima*, J. House*, H. Tam, D. Tokarz n, R. Smart*

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / administration & dosage; Animals; Apoptosis / drug effects; Apoptosis / genetics; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / genetics; Cell Differentiation; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Gene Expression Regulation, Neoplastic; Genes, Lethal; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Mice; Mice, Knockout; Receptors, Death Domain / genetics; Receptors, Death Domain / metabolism; Signal Transduction; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / administration & dosage; Tetradecanoylphorbol Acetate / analogs & derivatives; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism; ras Proteins / genetics; ras Proteins / metabolism
Sources: Web Of Science, ORCID, Crossref
Added: October 29, 2018

2018 journal article

Periconceptional maternal mediterranean diet is associated with favorable offspring behaviors and altered CpG methylation of imprinted genes

Frontiers in Cell and Developmental Biology, 6(SEP), 107.

By: J. House n, M. Mendez*, R. Maguire n, S. Gonzalez-Nahm*, Z. Huang*, J. Daniels*, S. Murphy*, B. Fuemmeler*, F. Wright n, C. Hoyo n

co-author countries: United States of America 🇺🇸

Contributors: J. House n, M. Mendez*, R. Maguire n, S. Gonzalez-Nahm*, Z. Huang*, J. Daniels*, S. Murphy*, B. Fuemmeler*, F. Wright n, C. Hoyo n

Sources: NC State University Libraries, ORCID
Added: January 21, 2019

2018 journal article

Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse

MAMMALIAN GENOME, 29(1-2), 168–181.

By: A. Venkatratnam*, J. House n, K. Konganti*, C. McKenney n, D. Threadgill*, W. Chiu*, D. Aylor n, F. Wright n, I. Rusyn*

co-author countries: United States of America 🇺🇸

Contributors: A. Venkatratnam*, J. House n, K. Konganti*, C. McKenney n, D. Threadgill*, W. Chiu*, D. Aylor n, F. Wright n, I. Rusyn*

MeSH headings : Animals; Dose-Response Relationship, Drug; Genetics, Population; Kidney / drug effects; Kidney / metabolism; Liver / drug effects; Liver / metabolism; Mice; Transcription, Genetic / drug effects; Transcriptome / genetics; Trichloroacetic Acid / metabolism; Trichloroethylene / toxicity
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip

SCIENTIFIC REPORTS, 8(1).

By: C. Sakolish*, E. Weber*, E. Kelly*, J. Himmelfarb*, R. Mouneimne*, F. Grimm*, J. House n, T. Wade* ...

co-author countries: United States of America 🇺🇸

Contributors: C. Sakolish*, E. Weber*, E. Kelly*, J. Himmelfarb*, R. Mouneimne*, F. Grimm*, J. House n, T. Wade* ...

MeSH headings : Anti-Bacterial Agents / toxicity; Cell Culture Techniques / instrumentation; Cell Line; Cell Survival / drug effects; Drug Development / instrumentation; Drug Evaluation, Preclinical / instrumentation; Humans; Kidney Tubules, Proximal / cytology; Kidney Tubules, Proximal / drug effects; Kidney Tubules, Proximal / metabolism; Lab-On-A-Chip Devices; Polymyxin B / toxicity; Technology Transfer; Vitamin D / metabolism
Sources: Web Of Science, ORCID
Added: October 19, 2018

2017 journal article

A pipeline for high-throughput concentration response modeling of gene expression for toxicogenomics

Frontiers in Genetics, 8(NOV).

By: J. House n, F. Grimm*, D. Jima n, Y. Zhou n, I. Rusyn* & F. Wright n

co-author countries: United States of America 🇺🇸

Contributors: J. House n, F. Grimm*, D. Jima n, Y. Zhou n, I. Rusyn* & F. Wright n

Sources: ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Adrenal-derived stress hormones modulate ozone-induced lung injury and inflammation

TOXICOLOGY AND APPLIED PHARMACOLOGY, 329, 249–258.

By: A. Henriquez*, J. House n, D. Miller*, S. Snow*, A. Fisher*, H. Ren*, M. Schladweiler*, A. Ledbetter*, F. Wright n, U. Kodavanti*

co-author countries: United States of America 🇺🇸

Contributors: A. Henriquez*, J. House n, D. Miller*, S. Snow*, A. Fisher*, H. Ren*, M. Schladweiler*, A. Ledbetter*, F. Wright n, U. Kodavanti*

author keywords: Ozone; Lung; Stress hormones; Adrenalectomy; RNAseq
MeSH headings : Adrenal Cortex / metabolism; Adrenal Cortex / surgery; Adrenal Medulla / metabolism; Adrenal Medulla / surgery; Adrenalectomy; Animals; Corticosterone / blood; Cytokines / metabolism; Disease Models, Animal; Epinephrine / blood; Gene Expression Regulation; Inflammation Mediators / metabolism; Lung / metabolism; Lung / pathology; Lung Injury / blood; Lung Injury / chemically induced; Lung Injury / genetics; Lung Injury / prevention & control; Male; Neutrophils / metabolism; Oxidative Stress; Ozone; Pneumonia / blood; Pneumonia / chemically induced; Pneumonia / genetics; Pneumonia / pathology; Pneumonia / prevention & control; RNA, Messenger / genetics; RNA, Messenger / metabolism; Rats, Inbred WKY; Signal Transduction; Stress, Physiological / genetics; Transcription, Genetic
Sources: ORCID, Web Of Science
Added: August 6, 2018

2017 journal article

Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study

Journal of Allergy and Clinical Immunology, 140(1), 249–256.e14.

By: J. House*, A. Wyss*, J. Hoppin n, M. Richards*, S. Long*, D. Umbach*, P. Henneberger*, B. Freeman ...

co-author countries: United States of America 🇺🇸

Contributors: J. House*, A. Wyss*, J. Hoppin n, M. Richards*, S. Long*, D. Umbach*, P. Henneberger*, L. Beane Freeman ...

author keywords: Agriculture; agricultural workers' diseases; allergy and immunology; asthma; hygiene hypothesis; IgE; prenatal exposure delayed effects
MeSH headings : Aged; Asthma / epidemiology; Case-Control Studies; Environmental Exposure; Farms; Female; Humans; Hypersensitivity, Immediate / blood; Hypersensitivity, Immediate / epidemiology; Immunoglobulin E / blood; Iowa / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Odds Ratio; Pulmonary Disease, Chronic Obstructive / epidemiology; Smoking / epidemiology
Sources: ORCID, Web Of Science, Crossref
Added: August 6, 2018

2017 journal article

Raw milk consumption and other early-life farm exposures and adult pulmonary function in the Agricultural Lung Health Study

Thorax, 73(3), 279–282.

By: A. Wyss*, J. House n, J. Hoppin n, M. Richards*, J. Hankinson, S. Long*, P. Henneberger*, L. Beane Freeman* ...

co-author countries: United States of America 🇺🇸

Contributors: A. Wyss*, J. House n, J. Hoppin n, M. Richards*, J. Hankinson, S. Long*, P. Henneberger*, L. Beane Freeman* ...

author keywords: COPD epidemiology; Asthma Epidemiology; Allergic lung disease; Occupational Lung Disease; Respiratory Measurement
MeSH headings : Adult; Aged; Agriculture; Animals; Case-Control Studies; Child; Child, Preschool; Environmental Exposure; Farms / statistics & numerical data; Female; Humans; Lung / physiopathology; Male; Middle Aged; Milk / physiology; Prospective Studies; Respiratory Physiological Phenomena; Spirometry / methods; United States
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2017 journal article

Vagal innervation is required for pulmonary function phenotype in htr4 –/– mice

American Journal of Physiology - Lung Cellular and Molecular Physiology, 312(4), L520–L530.

By: J. House*, C. Nichols*, H. Li*, C. Brandenberger*, R. Virgincar*, L. DeGraff*, B. Driehuys*, D. Zeldin*, S. London*

co-author countries: Germany 🇩🇪 United States of America 🇺🇸

Contributors: J. House*, C. Nichols*, H. Li*, C. Brandenberger*, R. Virgincar*, L. Degraff*, B. Driehuys*, D. Zeldin*, S. London*

MeSH headings : Animals; Genotype; In Vitro Techniques; Lung / innervation; Lung / physiology; Mice, Inbred C57BL; Muscle Contraction / physiology; Phenotype; Pulmonary Ventilation / physiology; Receptors, Serotonin, 5-HT4 / deficiency; Receptors, Serotonin, 5-HT4 / metabolism; Respiration; Respiratory Function Tests; Respiratory Hypersensitivity / physiopathology; Trachea / physiology; Vagotomy; Vagus Nerve / physiology; Vagus Nerve / surgery
Source: ORCID
Added: April 11, 2023

2015 journal article

Genetic variation in HTR4 and lung function: GWAS follow-up in mouse.

FASEB Journal, 29(1), 323–335.

By: J. House*, H. Li*, L. DeGraff*, G. Flake*, D. Zeldin* & S. London*

co-author countries: United States of America 🇺🇸

Contributors: J. House*, H. Li*, L. DeGraff*, G. Flake*, D. Zeldin* & S. London*

MeSH headings : Airway Resistance / genetics; Airway Resistance / physiology; Allergens / administration & dosage; Animals; Antigens, Dermatophagoides / administration & dosage; Bleomycin / toxicity; Bronchial Hyperreactivity / chemically induced; Bronchial Hyperreactivity / genetics; Bronchial Hyperreactivity / physiopathology; Genome-Wide Association Study; Humans; Lung / immunology; Lung / physiology; Male; Mice; Mice, Knockout; Polymorphism, Single Nucleotide; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / genetics; Pulmonary Fibrosis / physiopathology; Receptors, Serotonin, 5-HT4 / deficiency; Receptors, Serotonin, 5-HT4 / genetics; Receptors, Serotonin, 5-HT4 / physiology; Respiratory Function Tests; Species Specificity
Source: ORCID
Added: April 11, 2023

2015 journal article

Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation.

Drug Metabolism and Disposition, 43(8), 1169–1180.

By: J. Graves*, A. Gruzdev*, J. Bradbury*, L. DeGraff*, H. Li*, J. House*, S. Hoopes*, M. Edin*, D. Zeldin*

co-author countries: United States of America 🇺🇸

Contributors: J. Graves*, A. Gruzdev*, J. Bradbury*, L. DeGraff*, H. Li*, J. House*, S. Hoopes*, M. Edin*, D. Zeldin*

MeSH headings : Animals; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System / biosynthesis; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; DNA Primers; DNA, Complementary / biosynthesis; DNA, Complementary / genetics; Female; Gene Expression Regulation, Enzymologic / genetics; Hypersensitivity / enzymology; Hypersensitivity / genetics; Kidney / enzymology; Lung / enzymology; Male; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections / enzymology; Pollen / immunology; Polymerase Chain Reaction; Tissue Distribution; Zea mays / immunology
Source: ORCID
Added: April 11, 2023

2014 journal article

ADAM19 and HTR4 variants and pulmonary function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.

Circulation: Cardiovascular Genetics, 7(3), 350–358.

By: S. London, W. Gao, S. Gharib, D. Hancock, J. Wilk, J. House*, R. Gibbs, D. Muzny ...

Contributors: S. London, W. Gao, S. Gharib, D. Hancock, J. Wilk, J. House*, R. Gibbs, D. Muzny ...

MeSH headings : ADAM Proteins / genetics; Aged; Aged, 80 and over; Aging / genetics; Cohort Studies; Female; Genetic Variation; Genome-Wide Association Study; Genomics; Heart Diseases / epidemiology; Heart Diseases / genetics; Heart Diseases / physiopathology; Humans; Lung / physiopathology; Male; Middle Aged; Polymorphism, Single Nucleotide; Sequence Analysis, DNA
Source: ORCID
Added: April 11, 2023

2011 journal article

C/EBP alpha Expression Is Downregulated in Human Nonmelanoma Skin Cancers and Inactivation of C/EBP alpha Confers Susceptibility to UVB-Induced Skin Squamous Cell Carcinomas

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(6), 1339–1346.

By: E. Thompson n, S. Zhu n, J. Hall n, J. House n, R. Ranjan n, J. Burr n, Y. He*, D. Owens*, R. Smart n

co-author countries: United States of America 🇺🇸

Contributors: E. Thompson n, S. Zhu n, J. Hall n, J. House n, R. Ranjan n, J. Burr n, Y. He*, D. Owens*, R. Smart n

MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / analysis; CCAAT-Enhancer-Binding Protein-alpha / physiology; Carcinoma, Squamous Cell / chemistry; Carcinoma, Squamous Cell / etiology; Cell Cycle; Cells, Cultured; Genes, p53; Humans; Keratosis, Actinic / metabolism; Male; Mice; Mice, Hairless; Mice, Inbred C57BL; Mutation; Neoplasms, Radiation-Induced / etiology; Precancerous Conditions / chemistry; Skin / metabolism; Skin / radiation effects; Skin Neoplasms / chemistry; Skin Neoplasms / etiology; Ultraviolet Rays / adverse effects
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

C/EBP alpha and C/EBP beta Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin

PLOS ONE, 5(3).

By: J. House n, S. Zhu n, R. Ranjan n, K. Linder n & R. Smart n

co-author countries: United States of America 🇺🇸

Contributors: J. House n, S. Zhu n, R. Ranjan n, K. Linder n & R. Smart n

MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / physiology; CCAAT-Enhancer-Binding Protein-beta / physiology; Cell Cycle; Cell Differentiation; Cell Proliferation; Epithelial Cells / cytology; Gene Expression Regulation; Genotype; Homozygote; Immunoblotting; Immunohistochemistry / methods; Keratinocytes / cytology; Mice; Sebaceous Glands / cytology; Skin / cytology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

C/EBP beta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf)

CELL DEATH AND DIFFERENTIATION, 15(11), 1734–1744.

By: S. Ewing n, S. Zhu n, F. Zhu n, J. House n & R. Smart n

co-author countries: United States of America 🇺🇸

Contributors: S. Ewing n, S. Zhu n, F. Zhu n, J. House n & R. Smart n

author keywords: apoptosis; p53; C/EBP beta; p19(Arf); DNA damage; keratinocytes
MeSH headings : Animals; Apoptosis / drug effects; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / metabolism; Carcinogens / toxicity; Cell Survival / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Cyclophosphamide / administration & dosage; Cyclophosphamide / pharmacology; DNA Damage; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Injections, Intraperitoneal; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Mice; Oncogene Protein p21(ras) / metabolism; Protein Processing, Post-Translational / drug effects; Repressor Proteins / metabolism; Transcriptional Activation / drug effects; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
Sources: ORCID, Web Of Science
Added: August 6, 2018

Employment

Updated: December 31st, 2019 09:04

2019 - present

National Institute of Environmental Health Sciences RTP, NC, US
Staff Scientist Biostatistics & Computational Biology Branch

2016 - 2019

North Carolina State University Raleigh, NC, US
Senior Research Scholar Bioinformatics Research Center

2011 - 2016

National Institute of Environmental Health Sciences Durham, NC, US
Post-doctoral Researcher

Education

Updated: February 19th, 2018 10:40

2006 - 2011

North Carolina State University Raleigh, NC, US
PhD Toxicology

1994 - 1997

North Carolina State University Raleigh, NC, US
M. Stat Statistics

1990 - 1994

University of Tennessee Knoxville, TN, US
B.S. Biology

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