Works (62)

Updated: April 3rd, 2024 21:11

2024 journal article

Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs)

Exposome.

By: M. Chung*, J. House*, F. Akhtari*, K. Makris*, M. Langston*, K. Islam*, P. Holmes*, M. Chadeau-Hyam* ...

TL;DR: This paper introduces the exposome-wide association study (ExWAS), an approach designed for systematic discovery of relationships between phenotypes and various exposures, identifying significant associations while controlling for multiple comparisons. (via Semantic Scholar)
Source: ORCID
Added: January 26, 2024

2024 journal article

Guided optimization of ToxPi model weights using a Semi-Automated approach

COMPUTATIONAL TOXICOLOGY, 29.

By: J. Fleming n, J. House*, J. Chappel n, A. Motsinger-Reif* & D. Reif*

author keywords: Machine learning; Feature weighting; Exposure assessment; Chemical toxicity; Ordinal regression; Genetic algorithm
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024

2024 journal article

Interactive data sharing for multiple questionnaire-based exposome-wide association studies and exposome correlations in the Personalized Environment and Genes Study

Exposome.

By: D. Lloyd*, J. House*, F. Akhtari*, C. Schmitt*, D. Fargo*, E. Scholl*, J. Phillips*, S. Choksi* ...

TL;DR: The PEGS Explorer web application is developed to explore exposure correlations in data from the diverse North Carolina-based Personalized Environment and Genes Study (PEGS) that were rigorously calculated to account for differing data types and previously published results from ExWAS. (via Semantic Scholar)
Source: ORCID
Added: February 10, 2024

2024 journal article

Questionnaire-based exposome-wide association studies for common diseases in the Personalized Environment and Genes Study

Exposome.

By: D. Lloyd*, J. House*, F. Akhtari*, C. Schmitt*, D. Fargo*, E. Scholl*, J. Phillips*, S. Choksi* ...

TL;DR: An exposome-wide association study to examine single exposure models and their associations with 11 common complex diseases, namely allergic rhinitis, asthma, bone loss, fibroids, high cholesterol, hypertension, iron-deficient anemia, ovarian cysts, lower GI polyps, migraines, and type 2 diabetes is performed. (via Semantic Scholar)
Source: ORCID
Added: February 10, 2024

2023 article

A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo

Tsai, H.-H. D., House, J. S., Wright, F. A., Chiu, W. A., & Rusyn, I. (2023, April 20). TOXICOLOGICAL SCIENCES.

By: H. Tsai*, J. House*, F. Wright n, W. Chiu* & I. Rusyn*

author keywords: transcriptomic; petroleum; grouping; dose-response; HTTr; NAMs
MeSH headings : Humans; Transcriptome; Petroleum / toxicity; Endothelial Cells; Gene Expression Profiling; Cell Line
TL;DR: This study found that two cell types-iPSC-derived-hepatocytes and -cardiomyocytes-contributed the most informative and protective PODs and may be used to inform selection of representative petroleum UVCBs for further toxicity evaluation in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: May 22, 2023

2023 journal article

C/EBP beta deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors

INNATE IMMUNITY, 29(1-2), 14–24.

By: J. House n, S. Gray n, J. Owen n, D. Jima n, R. Smart n & J. Hall n

author keywords: C/EBP beta; cell death; keratinocytes; type I IFN response
MeSH headings : Animals; Mice; Caspase 3 / metabolism; Caspase 8 / metabolism; CCAAT-Enhancer-Binding Protein-beta / genetics; Immunity, Innate; Interferon Type I / metabolism; Keratinocytes; Receptors, Pattern Recognition / genetics; Receptors, Pattern Recognition / metabolism
TL;DR: The conditional deletion of C/EBPβ transcription factor in mouse epidermis resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs) and the expression of cytosolic pattern recognition receptors (cPRRs), that recognize viral RNA and DNA, were significantly increased, and enriched in the RNAseq data set. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 30, 2023

2023 article

Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Choudhary, P., Monasso, G. S., Karhunen, V., Ronkainen, J., Mancano, G., Howe, C. G., … Sebert, S. (2023, December 5). MOLECULAR PSYCHIATRY, Vol. 12.

By: P. Choudhary*, G. Monasso*, V. Karhunen*, J. Ronkainen*, G. Mancano*, C. Howe*, Z. Niu*, X. Zeng* ...

TL;DR: MEA was found to be associated with DNA methylation at 473 cytosine-phosphate-guanine sites at birth, one in childhood, and four in adolescence, directionally consistent with MEA being inversely associated with behaviours including smoking and BMI. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024

2023 journal article

Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats

Metabolomics.

TL;DR: Transcriptomic signatures of multiple tissues and serum metabolomics are assessed to understand how neuroendocrine and adrenal-derived stress hormones contribute to multiorgan health outcomes and allows characterization of the systemic inhaled pollutant-induced stress response. (via Semantic Scholar)
Source: ORCID
Added: January 26, 2024

2023 journal article

ToxicR: A computational platform in R for computational toxicology and dose–response analyses

Computational Toxicology, 25, 100259.

By: M. Wheeler*, S. Lim*, J. House*, K. Shockley*, A. John Bailer*, J. Fostel, L. Yang, D. Talley ...

TL;DR: The Biostatistics and Computational Biology Branch of the National Institute of Environmental Health Sciences, in cooperation with the National Toxicology Program and US Environmental Protection Agency, developed ToxicR, an open-source R programming package that implements many of the standard analyses used by the NTP and EPA. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023

2022 journal article

143-OR: Mapping Genetic Determinants of Blood Glucose Control in the Action to Control Cardiovascular Risk in Diabetes Study Group (ACCORD)

Diabetes, 71(Supplement_1).

By: J. House*, D. Rotroff, V. Fonseca, J. Hempe, J. Mychaleckyj, A. Doria, J. Buse, A. Motsinger Reif

TL;DR: This work identified and replicated variants that merit further study in the development of precision medicine for treatment of T2D and stratified analyses highlight the potential importance of heterogeneity in these efforts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 21, 2023

2022 journal article

Abstract PR011: Characterization of the precancerous and cancer microenvironment in a zebrafish sarcoma model

Clinical Cancer Research, 28(18_Supplement), PR011–PR011.

By: H. Shive*, J. House*, J. Ferguson n, D. Jima n, A. Selmek* & D. Lloyd n

TL;DR: Using RNA-seq, the transcriptomes of microenvironmental cells from the zebrafish MPNST model are profiled and it is determined that the precancerous and cancerous microenvironments exhibit broad activation of inflammatory and immune-associated signaling networks. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023

2022 journal article

Adrenal Stress Hormone Regulation of Hepatic Homeostatic Function After an Acute Ozone Exposure in Wistar-Kyoto Male Rats

Toxicological Sciences, 189(1), 73–90.

MeSH headings : Animals; Corticosterone; Homeostasis; Insulin; Male; Ozone / toxicity; RNA, Messenger; Rats; Rats, Inbred WKY
TL;DR: The critical role of adrenal stress hormones in ozone-induced hepatic homeostasis is demonstrated and necessitate further research elucidating their role in propagating environmentally driven diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 11, 2023

2022 journal article

Clomifene and Assisted Reproductive Technology in Humans Are Associated with Sex-Specific Offspring Epigenetic Alterations in Imprinted Control Regions

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(18).

author keywords: differentially methylated regions; adverse offspring outcomes; infertility
MeSH headings : Child; Clomiphene; DNA Methylation; Female; Genomic Imprinting; Humans; Male; Reproductive Techniques, Assisted / adverse effects; Retrospective Studies
TL;DR: The results suggest that the increased risk of adverse outcomes in offspring conceived through ART may be due in part to altered methylation of ICRs, and larger studies utilizing epigenome-wide interrogation are warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 3, 2022

2022 journal article

Comparison of National Vulnerability Indices Used by the Centers for Disease Control and Prevention for the COVID-19 Response

Public Health Reports, 137(4), 803–812.

author keywords: COVID-19; vulnerability; social vulnerability index; GIS; geographic information systems
MeSH headings : COVID-19 / epidemiology; COVID-19 / prevention & control; Centers for Disease Control and Prevention, U.S.; Humans; Pandemics / prevention & control; Public Health; United States / epidemiology
TL;DR: The indices can empower local and state public health officials with additional information to focus resources and interventions on disproportionately affected populations to combat the ongoing pandemic and plan for future pandemics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: May 6, 2022

2022 article

Genomic map of candidate human imprint control regions: the imprintome

Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). EPIGENETICS, Vol. 6.

By: D. Jima n, D. Skaar n, A. Planchart n, A. Motsinger-Reif n, S. Cevik n, S. Park n, M. Cowley n, F. Wright n ...

author keywords: Epigenetics; genomic imprinting; foetal origins; whole genome; methylation; imprint control regions
MeSH headings : Adult; Humans; Genomic Imprinting; DNA Methylation; Chromosome Mapping; Alleles; Genomics
TL;DR: This draft of the human imprintome will allow for the systematic determination of the role of early-acquired imprinting dysregulation in the pathogenesis of human diseases and developmental and behavioural disorders. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 11, 2022

2022 journal article

Grouping of UVCB Substances with Dose-Response Transcriptomics Data from Human Cell-Based Assays

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 39(3), 388–404.

By: J. House n, F. Grimm*, W. Klaren*, A. Dalzell*, S. Kuchi*, S. Zhang*, K. Lenz*, P. Boogaard ...

MeSH headings : Biological Assay; Endothelial Cells; Humans; Induced Pluripotent Stem Cells; Petroleum; Transcriptome
TL;DR: The results further demonstrate the value of NAMs for grouping of UVCBs, identify informative cell lines, and provide data that could be used for justifying selection of substances for further testing that may be required for registration. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 29, 2022

2022 journal article

LBMON114 Enrichment Of Rare Sequence Variants In Genes That Communicate Metabolic Signals To The GnRH System In Hypothalamic Amenorrhea

Journal of the Endocrine Society, 6(Supplement_1), A466–A467.

By: E. Brown, S. Shekhar, A. Delaney, A. Burkholder, L. Plummer, V. Mericq, P. Merino, R. Quinton ...

TL;DR: These data suggest that RSVs in genes involved in phenotypes or signaling pathways that link metabolism to GnRH secretion may predispose to development of HA in the setting of decreased energy balance, but not for stress-related genes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023

2022 journal article

Longitudinal Serological Surveillance for COVID-19 Antibodies after Infection and Vaccination

Microbiology Spectrum, 10(5).

By: C. McGee*, M. Shi*, J. House*, A. Drude*, G. Gonzalez*, N. Martin*, S. Chen*, H. Rogers* ...

Ed(s): O. Laeyendecker

MeSH headings : Humans; COVID-19 / prevention & control; Pandemics; Ad26COVS1; Vaccination; Antibodies; Antibodies, Viral
TL;DR: It is concluded that, in a real-life setting, vaccination and social distancing behavior are positively correlated and the observed effect of vaccination in preventing COVID-19 may include both vaccine-mediated protection and the associated more cautious behavior exhibited by vaccinated individuals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023

2022 journal article

Maternal Mediterranean Diet Adherence and Its Associations with Maternal Prenatal Stressors and Child Growth

CURRENT DEVELOPMENTS IN NUTRITION, 6(11).

By: S. Gonzalez-Nahm*, J. Marchesoni n, A. Maity n, R. Maguire n, J. House*, R. Tucker n, T. Atkinson n, S. Murphy*, C. Hoyo n

author keywords: Mediterranean diet; stressors; child weight; birth outcomes; maternal diet
TL;DR: If replicated in larger studies, the data suggest that MDA provides a potent avenue by which effects of prenatal stressors on maternal and fetal outcomes can be mitigated to reduce ethnic disparities in childhood obesity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 20, 2023

2022 journal article

Maternal Periconceptional Stressors, Mediterranean Diet Adherence, and Child Outcomes

Current Developments in Nutrition, 6, 650.

By: S. Gonzalez-Nahm*, J. Marchesoni n, A. Maity n, R. Maguire n, J. House*, R. Tucker n, T. Atkinson n, S. Murphy*, C. Hoyo n

TL;DR: The data suggest that maternal Mediterranean diet adherence provides a potent avenue by which effects of prenatal stressors on maternal and fetal outcomes can be mitigated to reduce ethnic disparities in childhood obesity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023

2022 journal article

Questionnaire-Based Polyexposure Assessment Outperforms Polygenic Scores for Classification of Type 2 Diabetes in a Multiancestry Cohort

Diabetes Care, 11, dc220295.

By: F. Akhtari*, D. Lloyd*, A. Burkholder*, X. Tong*, J. House*, E. Lee*, J. Buse*, S. Schurman* ...

MeSH headings : Humans; Diabetes Mellitus, Type 2 / epidemiology; Diabetes Mellitus, Type 2 / genetics; Hypertension / complications; Environmental Exposure; Multifactorial Inheritance / genetics; Surveys and Questionnaires; Genome-Wide Association Study; Risk Factors
TL;DR: The findings in a multiancestry cohort elucidate how type 2 diabetes odds can be attributed to clinical, genetic, and environmental factors and emphasize the need for exposome data in disease-risk association studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023

2022 journal article

Questionnaire-based exposome-wide association studies (ExWAS) reveal expected and novel risk factors associated with cardiovascular outcomes in the Personalized Environment and Genes Study

Environmental Research, 212, 113463.

By: E. Lee*, F. Akhtari*, J. House*, R. Simpson*, C. Schmitt*, D. Fargo*, S. Schurman*, J. Hall*, A. Motsinger-Reif*

MeSH headings : Cardiovascular Diseases / epidemiology; Cardiovascular Diseases / etiology; Coronary Artery Disease; Exposome; Heart Failure; Humans; Myocardial Infarction; Risk Factors; Stroke / epidemiology; Surveys and Questionnaires
TL;DR: ExWAS analyses revealed novel associations that include blood type A (Rh-) with heart attack, and significant nonlinear effects of sleep disorder, regular intake of grapefruit, and a family history of blood clotting problems for multiple CVD outcomes, highlighting the importance of considering multiple exposures when examining CVD outcome. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 11, 2023

2022 journal article

Social isolation exacerbates acute ozone inhalation induced pulmonary and systemic health outcomes

Toxicology and Applied Pharmacology, 457, 116295.

By: A. Henriquez*, S. Snow*, T. Jackson*, J. House*, D. Alewel*, M. Schladweiler*, M. Valdez*, D. Freeborn* ...

TL;DR: Collectively, psychosocial stressors, especially SI, affected the neuroendocrine system and induced adverse metabolic and inflammatory effects that were exacerbated by ozone exposure. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023

2022 journal article

Stress Drivers of Glucose Dynamics during Ozone Exposure Measured Using Radiotelemetry in Rats

Environmental Health Perspectives, 130(12).

By: A. Henriquez*, S. Snow*, T. Jackson*, J. House*, A. Motsinger-Reif*, C. Ward-Caviness*, M. Schladweiler*, D. Alewel* ...

MeSH headings : Rats; Male; Animals; Glucose; Receptors, Glucocorticoid; Blood Glucose Self-Monitoring; Irritants; Blood Glucose; Rats, Inbred WKY; Corticosterone; Ozone / toxicity; Air Pollutants / toxicity; Adrenergic Agents
TL;DR: The temporality of neuroendocrine-stress–mediated biological sequalae responsible for ozone-induced glucose metabolic dysfunction and mechanism in a rodent model is demonstrated and may be useful in identifying interactions among irritant pollutants and stress-related illnesses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: April 12, 2023

2021 journal article

Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome‐Wide Interaction Meta‐Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies

Clinical Pharmacology & Therapeutics, 110(3), 723–732.

By: C. McDonough*, H. Warren*, J. Jack n, A. Motsinger‐Reif*, N. Armstrong*, J. Bis*, J. House*, S. Singh* ...

MeSH headings : Black or African American / genetics; Aged; Antihypertensive Agents / therapeutic use; Blood Pressure / drug effects; Blood Pressure / genetics; Cardiovascular Diseases / chemically induced; Cardiovascular Diseases / genetics; Cardiovascular System / drug effects; Drug-Related Side Effects and Adverse Reactions / etiology; Drug-Related Side Effects and Adverse Reactions / genetics; Female; Genome-Wide Association Study / methods; Humans; Hypertension / drug therapy; Hypertension / genetics; Male; Middle Aged; Pharmacogenomic Testing / methods; Polymorphism, Single Nucleotide / genetics
TL;DR: The NTM region is associated with increased risk for adverse cardiovascular outcomes and less BP reduction in β-blocker treated patients and no SNPs attained genome-wide significance for any other drugs classes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 23, 2021

2021 journal article

Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort

PEDIATRIC OBESITY, 16(7).

By: R. Maguire n, J. House n, D. Lloyd n, H. Skinner n, T. Allen*, A. Raffi n, D. Skaar n, S. Park n ...

Contributors: R. Maguire n, J. House n, D. Lloyd n, H. Skinner n, T. Allen*, A. Raffi n, D. Skaar n, S. Park n ...

author keywords: cytokines; maternal obesity; childhood obesity
MeSH headings : Black or African American; Body Mass Index; Child; Child, Preschool; Cohort Studies; Cytokines / blood; Female; Humans; Obesity, Maternal / epidemiology; Pediatric Obesity / epidemiology; Pregnancy; White People
TL;DR: Although maternal systemic inflammation is hypothesized to link maternal pre‐pregnancy obesity to offspring metabolic dysfunction, patient empirical data are limited. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 19, 2021

2021 article

Glucose dynamics during ozone exposure measured using radiotelemetry: Stress drivers

Henriquez, A. R., Snow, S. J., Jackson, T. W., House, J. S., Motsinger-Reif, A. A., Ward-Caviness, C. K., … Kodavanti, U. P. (2021, December 9). (Vol. 12). Vol. 12.

By: A. Henriquez*, S. Snow*, T. Jackson, J. House*, A. Motsinger-Reif*, C. Ward-Caviness*, M. Schladweiler*, D. Alewel* ...

TL;DR: The temporality of neuroendocrine-stress-mediated biological sequalae responsible for ozone-induced metabolic dysfunction as exposure occurs is demonstrated for the first time. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 11, 2023

2021 journal article

Grouping of UVCB Substances with New Approach Methodologies (NAMs) Data

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 38(1), 123–137.

By: J. House n, F. Grimm*, W. Klaren*, A. Dalzell*, S. Kuchi*, S. Zhang*, K. Lenz*, P. Boogaard* ...

Contributors: J. House n, F. Grimm*, W. Klaren*, A. Dalzell*, S. Kuchi*, S. Zhang*, K. Lenz*, P. Boogaard* ...

MeSH headings : Animal Testing Alternatives / methods; Hazardous Substances / chemistry; Hazardous Substances / toxicity; Humans; Induced Pluripotent Stem Cells / drug effects; Petroleum / analysis; Petroleum / toxicity; Toxicity Tests / methods
TL;DR: It is demonstrated that in vitro test-derived biological activity signatures, including bioactivity from human induced pluripotent stem cell and primary cells, can be used to inform groupings of UVCBs, to assist in identification of representative substances in each group for testing when needed, and to fill data gaps by read-across. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 15, 2021

2021 journal article

High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs

PLOS GENETICS, 17(8).

By: F. Akhtari n, A. Green n, G. Small*, T. Havener*, J. House*, K. Roell n, D. Reif n, H. McLeod, T. Wiltshire*, A. Motsinger-Reif*

Ed(s): F. Vazquez

MeSH headings : Antineoplastic Agents / pharmacology; Biomarkers, Pharmacological / analysis; Cell Line, Tumor; Genome-Wide Association Study / methods; High-Throughput Screening Assays / methods; Humans; NAD(P)H Dehydrogenase (Quinone) / drug effects; NAD(P)H Dehydrogenase (Quinone) / genetics; NAD(P)H Dehydrogenase (Quinone) / metabolism
TL;DR: The NAD(P)H quinone dehydrogenase 1 (NQO1) gene was found to be associated with the dose-response of arsenic trioxide, erlotinib, tramet inib, and a combination treatment of paclitaxel + epirubicin. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 27, 2021

2021 journal article

Lrp1 regulation of pulmonary function follow-up of human GWAS in mice

American Journal of Respiratory Cell and Molecular Biology, 64(3), 368–378.

By: C. Nichols*, J. House*, H. Li*, J. Ward, A. Wyss, J. Williams*, L. Deterding*, J. Bradbury* ...

Contributors: C. Nichols*, J. House*, H. Li*, J. Ward, A. Wyss, J. Williams*, L. Deterding*, J. Bradbury* ...

MeSH headings : Animals; Bronchoalveolar Lavage Fluid; Genome-Wide Association Study; Humans; Lipopolysaccharides / pharmacology; Low Density Lipoprotein Receptor-Related Protein-1 / metabolism; Lung / physiology; Mice; Muscle, Smooth / drug effects; Muscle, Smooth / metabolism; Polymorphism, Single Nucleotide / genetics; Proteome / metabolism; Pyroglyphidae / physiology; Quantitative Trait Loci / genetics
TL;DR: Investigation of the effect of genetic disruption of the Lrp1 gene in smooth muscle cells on pulmonary function in naïve animals and after exposure to bacterial lipopolysaccharide (LPS) or house dust mite extract (HDME) suggests dysregulation of LRP1 in smoother muscle cells affects baseline pulmonary function and airway responsiveness. (via Semantic Scholar)
Source: ORCID
Added: April 11, 2023

2021 journal article

Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST

Nutrients, 13(9), 3180.

MeSH headings : Child Behavior Disorders / etiology; DNA Methylation; Dental Anxiety / etiology; Diet / adverse effects; Dietary Carbohydrates / adverse effects; Female; Glycemic Load / physiology; Humans; Impulsive Behavior; Infant; Infant Behavior; Male; Maternal Nutritional Physiological Phenomena; Pregnancy; Prenatal Exposure Delayed Effects / metabolism; Sex Factors; Temperament
TL;DR: Findings highlight the importance of maternal dietary patterns on offspring neurodevelopment, offering avenues for prevention options for mothers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
5. Gender Equality (Web of Science)
Source: ORCID
Added: April 11, 2023

2021 journal article

Peripheral metabolic effects of ozone exposure in healthy and diabetic rats on normal or high-cholesterol diet

Toxicology and Applied Pharmacology, 415, 115427.

By: S. Snow*, A. Henriquez*, A. Fisher*, B. Vallanat*, J. House*, M. Schladweiler*, C. Wood*, U. Kodavanti*

Contributors: S. Snow*, A. Henriquez*, A. Fisher*, B. Vallanat*, J. House*, M. Schladweiler*, C. Wood*, U. Kodavanti*

MeSH headings : Adipose Tissue, White / drug effects; Adipose Tissue, White / metabolism; Adipose Tissue, White / pathology; Air Pollutants / toxicity; Animals; Biomarkers / blood; Blood Glucose / drug effects; Blood Glucose / metabolism; Body Composition / drug effects; Cholesterol, Dietary / metabolism; Cholesterol, Dietary / toxicity; Diabetes Mellitus, Type 2 / blood; Diabetes Mellitus, Type 2 / complications; Diabetes Mellitus, Type 2 / genetics; Diet, High-Fat / adverse effects; Disease Models, Animal; Energy Metabolism / drug effects; Gene Expression Regulation; Inhalation Exposure; Insulin / blood; Lipids / blood; Liver / drug effects; Liver / metabolism; Liver / pathology; Male; Ozone / toxicity; Rats, Wistar; Species Specificity
TL;DR: Findings indicate that peripheral metabolic alterations induced by diabetes and high-cholesterol diet can enhance susceptibility to the metabolic effects of inhaled pollutants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: April 11, 2023

2021 personal communication

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning

Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y.-H., Wright, F. A., … Reif, D. M. (2021, January).

Contributors: S. Marvel n, J. House*, M. Wheeler*, K. Song n, Y. Zhou n, F. Wright n, W. Chiu*, I. Rusyn*, A. Motsinger-Reif*, D. Reif n

MeSH headings : COVID-19 / epidemiology; Data Visualization; Health Status Indicators; Humans; Machine Learning; Models, Statistical; Vulnerable Populations
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 22, 2021

2021 journal article

The Role of Hepatic Vagal Tone in Ozone-Induced Metabolic Dysfunction in the Liver

Toxicological Sciences, 181(2), 229–245.

By: C. Colonna*, A. Henriquez*, J. House*, A. Motsinger-Reif*, D. Alewel*, A. Fisher*, H. Ren*, S. Snow* ...

Contributors: C. Colonna*, A. Henriquez*, J. House*, A. Motsinger-Reif*, D. Alewel*, A. Fisher*, H. Ren*, S. Snow* ...

MeSH headings : Air Pollutants / toxicity; Animals; Liver; Male; Ozone / toxicity; Rats; Rats, Inbred WKY; Transcriptome
TL;DR: Parasympathetic innervation modulated ozone-induced liver transcriptional responses for cell growth and regeneration without affecting stress-mediated metabolic changes, which could collectively contribute to adverse effects of air pollutants on the liver. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 11, 2023

2020 journal article

Associations between Maternal Cadmium Exposure with Risk of Preterm Birth and Low after Birth Weight Effect of Mediterranean Diet Adherence on Affected Prenatal Outcomes

TOXICS, 8(4).

By: S. Gonzalez-Nahm*, K. Nihlani*, J. S. House*, R. L. Maguire n, H. G. Skinner n & C. Hoyo n

Contributors: S. Gonzalez-Nahm*, K. Nihlani*, J. House*, R. Maguire n, H. Skinner n & C. Hoyo n

author keywords: cadmium; heavy metals; birth weight; preterm birth; diet pattern; Mediterranean diet; pregnancy
TL;DR: The findings suggest that adherence to a Mediterranean dietary pattern during pregnancy may not mitigate cadmium exposure effects, and that larger studies are required to clarify these findings. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: January 19, 2021

2020 journal article

Fibrate pharmacogenomics: Expanding past the genome

Pharmacogenomics, 21(4), 293–306.

By: J. House* & A. Motsinger-Reif*

Contributors: J. House* & A. Motsinger-Reif*

MeSH headings : Cardiovascular Diseases / blood; Cardiovascular Diseases / drug therapy; Cardiovascular Diseases / genetics; Fibric Acids / therapeutic use; Genome / genetics; Genome-Wide Association Study / methods; Humans; Hypolipidemic Agents / therapeutic use; Pharmacogenetics / methods; Polymorphism, Single Nucleotide / genetics; Risk Factors; Triglycerides / blood
TL;DR: Heterogeneity in response to fibrate treatment is well established, and this variation is heritable, but recent innovations in technological platforms and advances in statistical methodologies are revolutionizing the use and integration of other 'omes' in pharmacogenomics studies. (via Semantic Scholar)
Source: ORCID
Added: April 11, 2023

2020 journal article

Low-Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells

SMALL, 16(21).

By: J. House n, E. Bouzos*, K. Fahy*, V. Francisco*, D. Lloyd n, F. Wright n, A. Motsinger-Reif*, P. Asuri*, K. Wheeler*

Contributors: J. House n, E. Bouzos*, K. Fahy*, V. Francisco*, D. Lloyd n, F. Wright n, A. Motsinger-Reif*, P. Asuri*, K. Wheeler*

author keywords: nanotoxicity; silver nanoparticles; transcriptomics
MeSH headings : Gene Expression / drug effects; Hepatocytes / drug effects; Humans; Metal Nanoparticles / chemistry; Silver; Surface Properties; Time Factors
TL;DR: Universal to all surface coatings, AgNP-treated cells responded by inactivating proliferation and enabling cell cycle checkpoints, which provide a foundation for understanding hepatic response to low-dose AgNPs for future risk assessment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 14, 2020

2020 article

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning

MedRxiv, Vol. 8.

By: S. Marvel n, J. House*, M. Wheeler*, K. Song n, Y. Zhou n, F. Wright n, W. Chiu*, I. Rusyn*, A. Motsinger-Reif*, D. Reif n

Contributors: S. Marvel n, J. House*, M. Wheeler*, K. Song n, Y. Zhou n, F. Wright n, W. Chiu*, I. Rusyn*, A. Motsinger-Reif*, D. Reif n

TL;DR: The Pandemic Vulnerability Index (PVI) presents a visual synthesis of county-level vulnerability indicators that can be compared in a regional, state, or nationwide context to enable more effective and coordinated action to combat the pandemic. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: August 21, 2020

2020 journal article

Tissue-Engineered Bone Tumor as a Reproducible Human in Vitro Model for Studies of Anticancer Drugs

TOXICOLOGICAL SCIENCES, 173(1), 65–76.

By: C. Sakolish*, J. House n, A. Chramiec*, Y. Liu*, Z. Chen*, S. Halligan*, G. Vunjak-Novakovic*, I. Rusyn*

Contributors: C. Sakolish*, J. House n, A. Chramiec*, Y. Liu*, Z. Chen*, S. Halligan*, G. Vunjak-Novakovic*, I. Rusyn*

author keywords: tissue chip; alternatives to animal testing < in vitro and alternatives; toxicogenomics < methods; safety evaluation; bone < systems toxicology
MeSH headings : Antineoplastic Agents / therapeutic use; Bone Neoplasms / drug therapy; Bone Neoplasms / metabolism; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cisplatin; Doxorubicin; Humans; Imidazoles; Osteoblasts; Pyrazines; Sarcoma, Ewing / drug therapy; Tissue Engineering / methods; Tumor Microenvironment; Vincristine
TL;DR: It is shown that a bioengineered human bone tumor can be used as a microphysiological model for pre-clinical studies of anticancer drugs and has predictive power in preclinical studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 3, 2020

2019 journal article

C/EBP beta suppresses keratinocyte autonomous type 1 IFN response and p53 to increase cell survival and susceptibility to UVB-induced skin cancer

CARCINOGENESIS, 40(9), 1099–1109.

By: H. Tam n, J. Hall n, Z. Messenger n, D. Jima n, J. House n, K. Linder n, R. Smart n

Contributors: H. Tam n, J. Hall n, Z. Messenger n, D. Jima n, J. House n, K. Linder n, R. Smart n

TL;DR: A p53-C/E BPβ feedback loop, whereby C/EBPβ a transcriptional target of a p53 pathway, functions as a survival factor by negatively regulating p53 apoptotic activity in response to DNA damage is suggested. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 18, 2019

2019 journal article

Cadmium exposure and MEG3 methylation differences between Whites and African Americans in the NEST Cohort

Environmental Epigenetics, 5(3).

Ed(s): M. Skinner

author keywords: maternal exposures; imprinted genes; offspring epigenetics; cadmium; CpG methylation; racial epigenetic outcome differences
TL;DR: Data support that prenatal Cd exposure is associated with aberrant methylation of the imprint regulatory element for the MEG3 gene cluster at birth, and neither house-dust nor water are likely exposure sources, and ingestion via contaminated hands is also unlikely to be a significant exposure route in this population. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 6, 2019

2019 journal article

Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization

PLOS ONE, 14(10).

Contributors: M. Onel*, B. Beykal*, K. Ferguson*, W. Chiu*, T. McDonald*, L. Zhou*, J. House n, F. Wright n ...

MeSH headings : Chemistry Techniques, Analytical / methods; Gas Chromatography-Mass Spectrometry; Petroleum / analysis; Principal Component Analysis; Reference Standards; Sample Size
TL;DR: A framework with unsupervised and supervised analyses to optimally group complex substances based on their analytical features is proposed and a quantitative comparative assessment of clustering results via Fowlkes–Mallows index, and classification results via model accuracies in predicting the group of an unknown complex substance is presented. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 1, 2020

2019 journal article

Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers

REGULATORY TOXICOLOGY AND PHARMACOLOGY, 101, 91–102.

By: F. Grimm*, J. House n, M. Wilson*, O. Sirenko*, Y. Iwata*, F. Wright n, N. Ball, I. Rusyn*

Contributors: F. Grimm*, J. House n, M. Wilson*, O. Sirenko*, Y. Iwata*, F. Wright n, N. Ball, I. Rusyn*

author keywords: New assessment methodologies; Glycol ethers; In vitro; ToxPi; Read-across; Safety assessment
MeSH headings : Animals; Cell Line; Ethers / classification; Ethers / toxicity; Glycols / classification; Glycols / toxicity; Humans; Risk Assessment; Solvents / classification; Solvents / toxicity; Toxicity Tests
TL;DR: In this study, a suite of organotypic and population‐based in vitro models are applied for comprehensive bioactivity profiling of twenty E‐Series and P‐Series glycol ethers, solvents with a broad variation in toxicity ranging from relatively non‐toxic to reproductive and hematopoetic system toxicants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 22, 2019

2019 journal article

Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing

JOURNAL OF CELL BIOLOGY, 218(6), 1994–2005.

By: K. Sai n, C. Parsons n, J. House n, S. Kathariou n & J. Ninomiya-Tsuji n

Contributors: K. Sai n, C. Parsons n, J. House n, S. Kathariou n & J. Ninomiya-Tsuji n

MeSH headings : Animals; Female; Humans; Listeria / growth & development; Listeria / immunology; Listeria / metabolism; Listeriosis / metabolism; Listeriosis / microbiology; Listeriosis / pathology; Listeriosis / prevention & control; Mice; Mice, Inbred C57BL; Mice, Knockout; Necroptosis; Protein Kinases / physiology; Receptor-Interacting Protein Serine-Threonine Kinases / genetics; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Receptor-Interacting Protein Serine-Threonine Kinases / physiology
TL;DR: The RIPK3-MLKL pathway protects epithelial cells from Listeria monocytogenes invasion but does not induce its oligomerization or necroptotic cell death, and instead targets intracellular bacteria and suppresses their replication. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 24, 2019

2019 journal article

Ozone-Induced Dysregulation of Neuroendocrine Axes Requires Adrenal-Derived Stress Hormones

TOXICOLOGICAL SCIENCES, 172(1), 38–50.

author keywords: ozone; brainstem; hypothalamus; pituitary; adrenalectomy; neuroendocrine hormones
TL;DR: Findings show that short-term ozone inhalation promotes a shift in brainstem and hypothalamic gene expression that is dependent on the presence of circulating adrenal-derived stress hormones, and is likely to have profound downstream influence on systemic effects of ozone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 18, 2019

2019 journal article

Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes

Toxicology and Applied Pharmacology, 381.

By: S. Burnett*, A. Blanchette*, F. Grimm*, J. House n, D. Reif n, F. Wright n, W. Chiu*, I. Rusyn*

Contributors: S. Burnett*, A. Blanchette*, F. Grimm*, J. House n, D. Reif n, F. Wright n, W. Chiu*, I. Rusyn*

author keywords: iPSC; In vitro; Alternative methods; Cardiotoxicity; High-content screening; Environmental chemicals
MeSH headings : Calcium / metabolism; Cardiotoxicity; Cells, Cultured; Drug Evaluation, Preclinical / methods; Female; Genotype; Humans; Induced Pluripotent Stem Cells / cytology; Male; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / metabolism; Phenotype; Racial Groups; Toxicity Tests / methods
TL;DR: This study shows the feasibility of using an organotypic population-based human in vitro model to quantitatively assess chemicals for which little cardiotoxicity information is available, and shows reproducible inter-individual variability in both baseline and chemical-induced effects on iPSC-derived cardiomyocytes. (via Semantic Scholar)
Source: ORCID
Added: August 30, 2019

2018 journal article

A Human Population-Based Organotypic In Vitro Model for Cardiotoxicity Screening

ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 35(4), 441–452.

By: F. Grimm*, A. Blanchette, J. House, K. Ferguson, N. Hsieh, C. Dalaijamts, A. Wright, B. Anson ...

Contributors: F. Grimm*, A. Blanchette, J. House, K. Ferguson, N. Hsieh, C. Dalaijamts, A. Wright, B. Anson ...

MeSH headings : Cardiotoxicity / genetics; Cardiovascular Agents / pharmacology; Cardiovascular Agents / toxicity; Cell Differentiation / drug effects; Cell Differentiation / genetics; Female; Healthy Volunteers; Humans; In Vitro Techniques; Induced Pluripotent Stem Cells / cytology; Induced Pluripotent Stem Cells / drug effects; Male; Myocytes, Cardiac / drug effects; Myocytes, Cardiac / physiology; Phenotype; Reproducibility of Results
TL;DR: iPSC-derived cardiomyocytes exhibited reproducible donor-specific differences in baseline function and drug-induced effects, demonstrating the feasibility of using a panel of population-based organotypic cells from healthy donors as an animal replacement experimental model to quantify inter-individual variability in xenobiotic responses. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 10, 2018

2018 journal article

C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event

Cell Death & Disease, 9(11).

By: Z. Messenger*, J. Hall*, D. Jima*, J. House*, H. Tam, D. Tokarz*, R. Smart*

Contributors: Z. Messenger*, J. Hall*, D. Jima*, J. House*, H. Tam, D. Tokarz*, R. Smart*

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / administration & dosage; Animals; Apoptosis / drug effects; Apoptosis / genetics; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / genetics; Cell Differentiation; Cell Transformation, Neoplastic / genetics; Cell Transformation, Neoplastic / metabolism; Cell Transformation, Neoplastic / pathology; Gene Expression Regulation, Neoplastic; Genes, Lethal; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratinocytes / pathology; Mice; Mice, Knockout; Receptors, Death Domain / genetics; Receptors, Death Domain / metabolism; Signal Transduction; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Tetradecanoylphorbol Acetate / administration & dosage; Tetradecanoylphorbol Acetate / analogs & derivatives; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism; ras Proteins / genetics; ras Proteins / metabolism
TL;DR: The results show that oncogenic Ras tumors display a significant DNA damage/replicative stress phenotype and these tumors have acquired a dependence on C/EBPβ for their survival, making it a promising target for future potential anticancer therapies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 29, 2018

2018 journal article

Periconceptional maternal mediterranean diet is associated with favorable offspring behaviors and altered CpG methylation of imprinted genes

Frontiers in Cell and Developmental Biology, 6(SEP), 107.

TL;DR: In this ethnically diverse cohort, maternal adherence to a Mediterranean diet in early pregnancy was associated with favorable neurobehavioral outcomes in early childhood and with sex-dependent methylation differences of MEG3, IGF2, and SGCE/PEG10 DMRs. (via Semantic Scholar)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: January 21, 2019

2018 journal article

Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse

MAMMALIAN GENOME, 29(1-2), 168–181.

By: A. Venkatratnam*, J. House n, K. Konganti*, C. McKenney n, D. Threadgill*, W. Chiu*, D. Aylor n, F. Wright n, I. Rusyn*

Contributors: A. Venkatratnam*, J. House n, K. Konganti*, C. McKenney n, D. Threadgill*, W. Chiu*, D. Aylor n, F. Wright n, I. Rusyn*

MeSH headings : Animals; Dose-Response Relationship, Drug; Genetics, Population; Kidney / drug effects; Kidney / metabolism; Liver / drug effects; Liver / metabolism; Mice; Transcription, Genetic / drug effects; Transcriptome / genetics; Trichloroacetic Acid / metabolism; Trichloroethylene / toxicity
TL;DR: The usefulness of mouse population-based studies in assessing inter-individual variation in toxicological responses is highlighted, but it is cautioned that genetic mapping may be challenging because of the complexity in gene exposure–dose relationships. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip

SCIENTIFIC REPORTS, 8(1).

By: C. Sakolish*, E. Weber*, E. Kelly*, J. Himmelfarb*, R. Mouneimne*, F. Grimm*, J. House n, T. Wade* ...

Contributors: C. Sakolish*, E. Weber*, E. Kelly*, J. Himmelfarb*, R. Mouneimne*, F. Grimm*, J. House n, T. Wade* ...

MeSH headings : Anti-Bacterial Agents / toxicity; Cell Culture Techniques / instrumentation; Cell Line; Cell Survival / drug effects; Drug Development / instrumentation; Drug Evaluation, Preclinical / instrumentation; Humans; Kidney Tubules, Proximal / cytology; Kidney Tubules, Proximal / drug effects; Kidney Tubules, Proximal / metabolism; Lab-On-A-Chip Devices; Polymyxin B / toxicity; Technology Transfer; Vitamin D / metabolism
TL;DR: While the overall transferability of this advanced tissue chip platform was a success, the reproducibility with the original report was greatly dependent on the cell source, demonstrating critical importance of developing microphysiological platforms using renewable cell sources. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 19, 2018

2017 journal article

A pipeline for high-throughput concentration response modeling of gene expression for toxicogenomics

Frontiers in Genetics, 8(NOV).

By: J. House n, F. Grimm*, D. Jima n, Y. Zhou n, I. Rusyn* & F. Wright n

Contributors: J. House n, F. Grimm*, D. Jima n, Y. Zhou n, I. Rusyn* & F. Wright n

TL;DR: Using data from induced pluripotent stem cell-derived cardiomyocytes treated with chemicals at varying concentrations, a pipeline is made available for handling expression data generated by TempO-Seq to align reads, clean and normalize raw count data, identify differentially expressed genes, and calculate transcriptomic concentration–response points of departure. (via Semantic Scholar)
Sources: ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2017 journal article

Adrenal-derived stress hormones modulate ozone-induced lung injury and inflammation

TOXICOLOGY AND APPLIED PHARMACOLOGY, 329, 249–258.

By: A. Henriquez*, J. House n, D. Miller*, S. Snow*, A. Fisher*, H. Ren*, M. Schladweiler*, A. Ledbetter*, F. Wright n, U. Kodavanti*

Contributors: A. Henriquez*, J. House n, D. Miller*, S. Snow*, A. Fisher*, H. Ren*, M. Schladweiler*, A. Ledbetter*, F. Wright n, U. Kodavanti*

author keywords: Ozone; Lung; Stress hormones; Adrenalectomy; RNAseq
MeSH headings : Adrenal Cortex / metabolism; Adrenal Cortex / surgery; Adrenal Medulla / metabolism; Adrenal Medulla / surgery; Adrenalectomy; Animals; Corticosterone / blood; Cytokines / metabolism; Disease Models, Animal; Epinephrine / blood; Gene Expression Regulation; Inflammation Mediators / metabolism; Lung / metabolism; Lung / pathology; Lung Injury / blood; Lung Injury / chemically induced; Lung Injury / genetics; Lung Injury / prevention & control; Male; Neutrophils / metabolism; Oxidative Stress; Ozone; Pneumonia / blood; Pneumonia / chemically induced; Pneumonia / genetics; Pneumonia / pathology; Pneumonia / prevention & control; RNA, Messenger / genetics; RNA, Messenger / metabolism; Rats, Inbred WKY; Signal Transduction; Stress, Physiological / genetics; Transcription, Genetic
TL;DR: It is demonstrated that ozone‐induced lung injury and neutrophilic inflammation require the presence of circulating epinephrine and corticosterone, which transcriptionally regulates signaling mechanisms involved in this response. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: August 6, 2018

2017 journal article

Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study

Journal of Allergy and Clinical Immunology, 140(1), 249–256.e14.

By: J. House*, A. Wyss*, J. Hoppin n, M. Richards*, S. Long*, D. Umbach*, P. Henneberger*, B. Freeman ...

Contributors: J. House*, A. Wyss*, J. Hoppin n, M. Richards*, S. Long*, D. Umbach*, P. Henneberger*, L. Beane Freeman ...

author keywords: Agriculture; agricultural workers' diseases; allergy and immunology; asthma; hygiene hypothesis; IgE; prenatal exposure delayed effects
MeSH headings : Aged; Asthma / epidemiology; Case-Control Studies; Environmental Exposure; Farms; Female; Humans; Hypersensitivity, Immediate / blood; Hypersensitivity, Immediate / epidemiology; Immunoglobulin E / blood; Iowa / epidemiology; Male; Middle Aged; North Carolina / epidemiology; Odds Ratio; Pulmonary Disease, Chronic Obstructive / epidemiology; Smoking / epidemiology
TL;DR: In a large US farming population, early‐life farm exposures, particularly maternal farming activities while pregnant, were strongly associated with reduced risk of atopy in adults, suggesting that protective associations of early‐ life farming exposures on atopy endure across the life course. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Raw milk consumption and other early-life farm exposures and adult pulmonary function in the Agricultural Lung Health Study

Thorax, 73(3), 279–282.

By: A. Wyss*, J. House n, J. Hoppin n, M. Richards*, J. Hankinson, S. Long*, P. Henneberger*, L. Beane Freeman* ...

Contributors: A. Wyss*, J. House n, J. Hoppin n, M. Richards*, J. Hankinson, S. Long*, P. Henneberger*, L. Beane Freeman* ...

author keywords: COPD epidemiology; Asthma Epidemiology; Allergic lung disease; Occupational Lung Disease; Respiratory Measurement
MeSH headings : Adult; Aged; Agriculture; Animals; Case-Control Studies; Child; Child, Preschool; Environmental Exposure; Farms / statistics & numerical data; Female; Humans; Lung / physiopathology; Male; Middle Aged; Milk / physiology; Prospective Studies; Respiratory Physiological Phenomena; Spirometry / methods; United States
TL;DR: A novel association between raw milk consumption and higher pulmonary function that lasts into older adulthood is reported and did not find appreciable associations with other early-life farming exposures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Vagal innervation is required for pulmonary function phenotype in htr4 <sup>–/–</sup> mice

American Journal of Physiology - Lung Cellular and Molecular Physiology, 312(4), L520–L530.

By: J. House*, C. Nichols*, H. Li*, C. Brandenberger*, R. Virgincar*, L. DeGraff*, B. Driehuys*, D. Zeldin*, S. London*

Contributors: J. House*, C. Nichols*, H. Li*, C. Brandenberger*, R. Virgincar*, L. Degraff*, B. Driehuys*, D. Zeldin*, S. London*

MeSH headings : Animals; Genotype; In Vitro Techniques; Lung / innervation; Lung / physiology; Mice, Inbred C57BL; Muscle Contraction / physiology; Phenotype; Pulmonary Ventilation / physiology; Receptors, Serotonin, 5-HT4 / deficiency; Receptors, Serotonin, 5-HT4 / metabolism; Respiration; Respiratory Function Tests; Respiratory Hypersensitivity / physiopathology; Trachea / physiology; Vagotomy; Vagus Nerve / physiology; Vagus Nerve / surgery
TL;DR: It is reported here that the Htr4-/- phenotype in mouse is dependent on vagal innervation to the lung, and results suggest that HTR4's role in pulmonary function likely relates to neural innervation and control of breathing. (via Semantic Scholar)
Source: ORCID
Added: April 11, 2023

2015 journal article

Genetic variation in HTR4 and lung function: GWAS follow-up in mouse.

FASEB Journal, 29(1), 323–335.

By: J. House*, H. Li*, L. DeGraff*, G. Flake*, D. Zeldin* & S. London*

Contributors: J. House*, H. Li*, L. DeGraff*, G. Flake*, D. Zeldin* & S. London*

MeSH headings : Airway Resistance / genetics; Airway Resistance / physiology; Allergens / administration & dosage; Animals; Antigens, Dermatophagoides / administration & dosage; Bleomycin / toxicity; Bronchial Hyperreactivity / chemically induced; Bronchial Hyperreactivity / genetics; Bronchial Hyperreactivity / physiopathology; Genome-Wide Association Study; Humans; Lung / immunology; Lung / physiology; Male; Mice; Mice, Knockout; Polymorphism, Single Nucleotide; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / genetics; Pulmonary Fibrosis / physiopathology; Receptors, Serotonin, 5-HT4 / deficiency; Receptors, Serotonin, 5-HT4 / genetics; Receptors, Serotonin, 5-HT4 / physiology; Respiratory Function Tests; Species Specificity
TL;DR: The findings of altered baseline lung function and increased AHR in Htr4‐null mice support a causal relationship between genetic variation in HTR4 and pulmonary function identified in human GWAS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 11, 2023

2015 journal article

Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation.

Drug Metabolism and Disposition, 43(8), 1169–1180.

By: J. Graves*, A. Gruzdev*, J. Bradbury*, L. DeGraff*, H. Li*, J. House*, S. Hoopes*, M. Edin*, D. Zeldin*

Contributors: J. Graves*, A. Gruzdev*, J. Bradbury*, L. DeGraff*, H. Li*, J. House*, S. Hoopes*, M. Edin*, D. Zeldin*

MeSH headings : Animals; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System / biosynthesis; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; DNA Primers; DNA, Complementary / biosynthesis; DNA, Complementary / genetics; Female; Gene Expression Regulation, Enzymologic / genetics; Hypersensitivity / enzymology; Hypersensitivity / genetics; Kidney / enzymology; Lung / enzymology; Male; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections / enzymology; Pollen / immunology; Polymerase Chain Reaction; Tissue Distribution; Zea mays / immunology
TL;DR: New methods and results for quantitative polymerase chain reaction (qPCR) analysis for the seven genes of the mouse Cyp2j subfamily of cytochrome P450 CYP2J subfamily are reported, and the Cyp2 j isoforms determined are determined, which confirmed similar patterns of expression between the two qPCR methods. (via Semantic Scholar)
Source: ORCID
Added: April 11, 2023

2014 journal article

ADAM19 and HTR4 variants and pulmonary function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.

Circulation: Cardiovascular Genetics, 7(3), 350–358.

By: S. London, W. Gao, S. Gharib, D. Hancock, J. Wilk, J. House*, R. Gibbs, D. Muzny ...

Contributors: S. London, W. Gao, S. Gharib, D. Hancock, J. Wilk, J. House*, R. Gibbs, D. Muzny ...

MeSH headings : ADAM Proteins / genetics; Aged; Aged, 80 and over; Aging / genetics; Cohort Studies; Female; Genetic Variation; Genome-Wide Association Study; Genomics; Heart Diseases / epidemiology; Heart Diseases / genetics; Heart Diseases / physiopathology; Humans; Lung / physiopathology; Male; Middle Aged; Polymorphism, Single Nucleotide; Sequence Analysis, DNA
TL;DR: 1 common variant associated with FEV1/FVC independent of the sentinel ADAM19 GWAS hit is identified and supports the original HTR4 GWAS findings, and rare variants do not seem to underlie GWAS associations with pulmonary function for common variants in ADAM 19 and HTR 4. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: April 11, 2023

2011 journal article

C/EBP alpha Expression Is Downregulated in Human Nonmelanoma Skin Cancers and Inactivation of C/EBP alpha Confers Susceptibility to UVB-Induced Skin Squamous Cell Carcinomas

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(6), 1339–1346.

By: E. Thompson n, S. Zhu n, J. Hall n, J. House n, R. Ranjan n, J. Burr n, Y. He*, D. Owens*, R. Smart n

Contributors: E. Thompson n, S. Zhu n, J. Hall n, J. House n, R. Ranjan n, J. Burr n, Y. He*, D. Owens*, R. Smart n

MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / analysis; CCAAT-Enhancer-Binding Protein-alpha / physiology; Carcinoma, Squamous Cell / chemistry; Carcinoma, Squamous Cell / etiology; Cell Cycle; Cells, Cultured; Genes, p53; Humans; Keratosis, Actinic / metabolism; Male; Mice; Mice, Hairless; Mice, Inbred C57BL; Mutation; Neoplasms, Radiation-Induced / etiology; Precancerous Conditions / chemistry; Skin / metabolism; Skin / radiation effects; Skin Neoplasms / chemistry; Skin Neoplasms / etiology; Ultraviolet Rays / adverse effects
TL;DR: It is observed that C/EBPα is induced in normal human epidermal keratinocytes and in the epidermis of human subjects exposed to UVB radiation, and loss of C/ EBPα confers susceptibility toUVB-induced skin SCCs involving defective cell cycle arrest in response to UVBs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 journal article

C/EBP alpha and C/EBP beta Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin

PLOS ONE, 5(3).

By: J. House n, S. Zhu n, R. Ranjan n, K. Linder n & R. Smart n

Contributors: J. House n, S. Zhu n, R. Ranjan n, K. Linder n & R. Smart n

MeSH headings : Animals; CCAAT-Enhancer-Binding Protein-alpha / physiology; CCAAT-Enhancer-Binding Protein-beta / physiology; Cell Cycle; Cell Differentiation; Cell Proliferation; Epithelial Cells / cytology; Gene Expression Regulation; Genotype; Homozygote; Immunoblotting; Immunohistochemistry / methods; Keratinocytes / cytology; Mice; Sebaceous Glands / cytology; Skin / cytology
TL;DR: Results indicate that in adult mouse skin, C/EBPα and C-EBPβ are critically involved in regulating sebocyte differentiation and epidermal homeostasis involving the basal to spinous keratinocyte transition and basal cell cycle withdrawal. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 journal article

C/EBP beta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf)

CELL DEATH AND DIFFERENTIATION, 15(11), 1734–1744.

By: S. Ewing n, S. Zhu n, F. Zhu n, J. House n & R. Smart n

Contributors: S. Ewing n, S. Zhu n, F. Zhu n, J. House n & R. Smart n

author keywords: apoptosis; p53; C/EBP beta; p19(Arf); DNA damage; keratinocytes
MeSH headings : Animals; Apoptosis / drug effects; CCAAT-Enhancer-Binding Protein-beta / deficiency; CCAAT-Enhancer-Binding Protein-beta / metabolism; Carcinogens / toxicity; Cell Survival / drug effects; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Cyclophosphamide / administration & dosage; Cyclophosphamide / pharmacology; DNA Damage; Epidermal Cells; Epidermis / drug effects; Epidermis / metabolism; Injections, Intraperitoneal; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Mice; Oncogene Protein p21(ras) / metabolism; Protein Processing, Post-Translational / drug effects; Repressor Proteins / metabolism; Transcriptional Activation / drug effects; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism
TL;DR: Results suggest that inhibition of C/EBPβ may be a target for cancer cotherapy to increase the efficacy of alkylating chemotherapeutic agents and suggest that p19Arf represses p53 to promote cell survival downstream of DNA damage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 6, 2018

Employment

Updated: December 31st, 2019 09:04

2019 - present

National Institute of Environmental Health Sciences RTP, NC, US
Staff Scientist Biostatistics & Computational Biology Branch

2016 - 2019

North Carolina State University Raleigh, NC, US
Senior Research Scholar Bioinformatics Research Center

2011 - 2016

National Institute of Environmental Health Sciences Durham, NC, US
Post-doctoral Researcher

Education

Updated: February 19th, 2018 10:40

2006 - 2011

North Carolina State University Raleigh, NC, US
PhD Toxicology

1994 - 1997

North Carolina State University Raleigh, NC, US
M. Stat Statistics

1990 - 1994

University of Tennessee Knoxville, TN, US
B.S. Biology

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