John House

Chung, M. K., House, J. S., Akhtari, F. S., Makris, K. C., Langston, M. A., Islam, K. T., … Zhu, Y. (2024). Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs). Exposome. https://doi.org/10.1093/exposome/osae001

Fleming, J. F., House, J. S., Chappel, J. R., Motsinger-Reif, A. A., & Reif, D. M. (2024). Guided optimization of ToxPi model weights using a Semi-Automated approach. COMPUTATIONAL TOXICOLOGY, 29. https://doi.org/10.1016/j.comtox.2023.100294

Lloyd, D., House, J. S., Akhtari, F. S., Schmitt, C. P., Fargo, D. C., Scholl, E. H., … Motsinger-Reif, A. A. (2024). Interactive data sharing for multiple questionnaire-based exposome-wide association studies and exposome correlations in the Personalized Environment and Genes Study. Exposome. https://doi.org/10.1093/exposome/osae003

Lloyd, D., House, J. S., Akhtari, F. S., Schmitt, C. P., Fargo, D. C., Scholl, E. H., … Motsinger-Reif, A. A. (2024). Questionnaire-based exposome-wide association studies for common diseases in the Personalized Environment and Genes Study. Exposome. https://doi.org/10.1093/exposome/osae002

Tsai, H.-H. D., House, J. S., Wright, F. A., Chiu, W. A., & Rusyn, I. (2023, April 20). A tiered testing strategy based on in vitro phenotypic and transcriptomic data for selecting representative petroleum UVCBs for toxicity evaluation in vivo. TOXICOLOGICAL SCIENCES. https://doi.org/10.1093/toxsci/kfad041

House, J. S., Gray, S., Owen, J. R., Jima, D. D., Smart, R. C., & Hall, J. R. (2023). C/EBP beta deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors. INNATE IMMUNITY, 29(1-2), 14–24. https://doi.org/10.1177/17534259231162192

Choudhary, P., Monasso, G. S., Karhunen, V., Ronkainen, J., Mancano, G., Howe, C. G., … Sebert, S. (2023, December 5). Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence. MOLECULAR PSYCHIATRY, Vol. 12. https://doi.org/10.1038/s41380-023-02331-5

Jackson, T. W., House, J. S., Henriquez, A. R., Schladweiler, M. C., Jackson, K. M. P., Fisher, A. A., … Kodavanti, U. P. (2023). Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats. Metabolomics. https://doi.org/10.1007/s11306-023-02043-5

Wheeler, M. W., Lim, S., House, J. S., Shockley, K. R., John Bailer, A., Fostel, J., … Motsinger-Reif, A. A. (2023). ToxicR: A computational platform in R for computational toxicology and dose–response analyses. Computational Toxicology, 25, 100259. https://doi.org/10.1016/j.comtox.2022.100259

House, J. S., Rotroff, D. M., Fonseca, V., Hempe, J. M., Mychaleckyj, J., Doria, A., … Motsinger Reif, A. (2022). 143-OR: Mapping Genetic Determinants of Blood Glucose Control in the Action to Control Cardiovascular Risk in Diabetes Study Group (ACCORD). Diabetes, 71(Supplement_1). https://doi.org/10.2337/db22-143-OR

Shive, H. R., House, J. S., Ferguson, J. L., Jima, D. D., Selmek, A. A., & Lloyd, D. T. (2022). Abstract PR011: Characterization of the precancerous and cancer microenvironment in a zebrafish sarcoma model. Clinical Cancer Research, 28(18_Supplement), PR011–PR011. https://doi.org/10.1158/1557-3265.SARCOMAS22-PR011

Jackson, T. W., Henriquez, A. R., Snow, S. J., Schladweiler, M. C., Fisher, A. A., Alewel, D. I., … Kodavanti, U. P. (2022). Adrenal Stress Hormone Regulation of Hepatic Homeostatic Function After an Acute Ozone Exposure in Wistar-Kyoto Male Rats. Toxicological Sciences, 189(1), 73–90. https://doi.org/10.1093/toxsci/kfac065

Lloyd, D. T., Skinner, H. G., Maguire, R., Murphy, S. K., Motsinger-Reif, A. A., Hoyo, C., & House, J. S. (2022). Clomifene and Assisted Reproductive Technology in Humans Are Associated with Sex-Specific Offspring Epigenetic Alterations in Imprinted Control Regions. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(18). https://doi.org/10.3390/ijms231810450

Wolkin, A., Collier, S., House, J. S., Reif, D., Motsinger-Reif, A., Duca, L., & Sharpe, J. D. (2022). Comparison of National Vulnerability Indices Used by the Centers for Disease Control and Prevention for the COVID-19 Response. Public Health Reports, 137(4), 803–812. https://doi.org/10.1177/00333549221090262

Jima, D. D., Skaar, D. A., Planchart, A., Motsinger-Reif, A., Cevik, S. E., Park, S. S., … Hoyo, C. (2022, June 25). Genomic map of candidate human imprint control regions: the imprintome. EPIGENETICS, Vol. 6. https://doi.org/10.1080/15592294.2022.2091815

House, J. S., Grimm, F. A., Klaren, W. D., Dalzell, A., Kuchi, S., Zhang, S.-D., … Wright, F. A. (2022). Grouping of UVCB Substances with Dose-Response Transcriptomics Data from Human Cell-Based Assays. ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 39(3), 388–404. https://doi.org/10.14573/altex.2107051

Brown, E., Shekhar, S., Delaney, A., Burkholder, A. B., Plummer, L., Mericq, V., … Hall, J. (2022). LBMON114 Enrichment Of Rare Sequence Variants In Genes That Communicate Metabolic Signals To The GnRH System In Hypothalamic Amenorrhea. Journal of the Endocrine Society, 6(Supplement_1), A466–A467. https://doi.org/10.1210/jendso/bvac150.970

McGee, C., Shi, M., House, J., Drude, A., Gonzalez, G., Martin, N., … Garantziotis, S. (2022). Longitudinal Serological Surveillance for COVID-19 Antibodies after Infection and Vaccination. Microbiology Spectrum, 10(5). https://doi.org/10.1128/spectrum.02026-22

Gonzalez-Nahm, S., Marchesoni, J., Maity, A., Maguire, R. L., House, J. S., Tucker, R., … Hoyo, C. (2022). Maternal Mediterranean Diet Adherence and Its Associations with Maternal Prenatal Stressors and Child Growth. CURRENT DEVELOPMENTS IN NUTRITION, 6(11). https://doi.org/10.1093/cdn/nzac146

Gonzalez-Nahm, S., Marchesoni, J., Maity, A., Maguire, R., House, J., Tucker, R., … Hoyo, C. (2022). Maternal Periconceptional Stressors, Mediterranean Diet Adherence, and Child Outcomes. Current Developments in Nutrition, 6, 650. https://doi.org/10.1093/cdn/nzac061.034

Akhtari, F. S., Lloyd, D., Burkholder, A., Tong, X., House, J. S., Lee, E. Y., … Motsinger-Reif, A. A. (2022). Questionnaire-Based Polyexposure Assessment Outperforms Polygenic Scores for Classification of Type 2 Diabetes in a Multiancestry Cohort. Diabetes Care, 11, dc220295. https://doi.org/10.2337/dc22-0295

Lee, E. Y., Akhtari, F., House, J. S., Simpson, R. J., Jr., Schmitt, C. P., Fargo, D. C., … Motsinger-Reif, A. A. (2022). Questionnaire-based exposome-wide association studies (ExWAS) reveal expected and novel risk factors associated with cardiovascular outcomes in the Personalized Environment and Genes Study. Environmental Research, 212, 113463. https://doi.org/10.1016/j.envres.2022.113463

Henriquez, A. R., Snow, S. J., Jackson, T. W., House, J. S., Alewel, D. I., Schladweiler, M. C., … Kodavanti, U. P. (2022). Social isolation exacerbates acute ozone inhalation induced pulmonary and systemic health outcomes. Toxicology and Applied Pharmacology, 457, 116295. https://doi.org/10.1016/j.taap.2022.116295

Henriquez, A. R., Snow, S. J., Jackson, T. W., House, J. S., Motsinger-Reif, A. A., Ward-Caviness, C. K., … Kodavanti, U. P. (2022). Stress Drivers of Glucose Dynamics during Ozone Exposure Measured Using Radiotelemetry in Rats. Environmental Health Perspectives, 130(12). https://doi.org/10.1289/EHP11088

McDonough, C. W., Warren, H. R., Jack, J. R., Motsinger‐Reif, A. A., Armstrong, N. D., Bis, J. C., … Cooper‐DeHoff, R. M. (2021). Adverse Cardiovascular Outcomes and Antihypertensive Treatment: A Genome‐Wide Interaction Meta‐Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies. Clinical Pharmacology & Therapeutics, 110(3), 723–732. https://doi.org/10.1002/cpt.2355

Maguire, R. L., House, J. S., Lloyd, D. T., Skinner, H. G., Allen, T. K., Raffi, A. M., … Hoyo, C. (2021). Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort. PEDIATRIC OBESITY, 16(7). https://doi.org/10.1111/ijpo.12763

Henriquez, A. R., Snow, S. J., Jackson, T. W., House, J. S., Motsinger-Reif, A. A., Ward-Caviness, C. K., … Kodavanti, U. P. (2021, December 9). Glucose dynamics during ozone exposure measured using radiotelemetry: Stress drivers (Vol. 12). Vol. 12. https://doi.org/10.1101/2021.12.09.471963

House, J. S., Grimm, F. A., Klaren, W. D., Dalzell, A., Kuchi, S., Zhang, S.-D., … Rusyn, I. (2021). Grouping of UVCB Substances with New Approach Methodologies (NAMs) Data. ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 38(1), 123–137. https://doi.org/10.14573/altex.2006262

Akhtari, F. S., Green, A. J., Small, G. W., Havener, T. M., House, J. S., Roell, K. R., … Motsinger-Reif, A. A. (2021). High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs. PLOS GENETICS, 17(8). https://doi.org/10.1371/journal.pgen.1009732

Nichols, C. E., House, J. S., Li, H., Ward, J. M., Wyss, A., Williams, J. G., … London, S. J. (2021). Lrp1 regulation of pulmonary function follow-up of human GWAS in mice. American Journal of Respiratory Cell and Molecular Biology, 64(3), 368–378. https://doi.org/10.1165/rcmb.2019-0444OC

Alick, C. L., Maguire, R. L., Murphy, S. K., Fuemmeler, B. F., Hoyo, C., & House, J. S. (2021). Periconceptional Maternal Diet Characterized by High Glycemic Loading Is Associated with Offspring Behavior in NEST. Nutrients, 13(9), 3180. https://doi.org/10.3390/nu13093180

Snow, S. J., Henriquez, A. R., Fisher, A., Vallanat, B., House, J. S., Schladweiler, M. C., … Kodavanti, U. P. (2021). Peripheral metabolic effects of ozone exposure in healthy and diabetic rats on normal or high-cholesterol diet. Toxicology and Applied Pharmacology, 415, 115427. https://doi.org/10.1016/j.taap.2021.115427

Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y.-H., Wright, F. A., … Reif, D. M. (2021, January). The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning. https://doi.org/10.1289/EHP8690

Colonna, C. H., Henriquez, A. R., House, J. S., Motsinger-Reif, A. A., Alewel, D. I., Fisher, A., … Kodavanti, U. P. (2021). The Role of Hepatic Vagal Tone in Ozone-Induced Metabolic Dysfunction in the Liver. Toxicological Sciences, 181(2), 229–245. https://doi.org/10.1093/toxsci/kfab025

Gonzalez-Nahm, S., Nihlani, K., S. House, J., L. Maguire, R., G. Skinner, H., & Hoyo, C. (2020). Associations between Maternal Cadmium Exposure with Risk of Preterm Birth and Low after Birth Weight Effect of Mediterranean Diet Adherence on Affected Prenatal Outcomes. TOXICS, 8(4). https://doi.org/10.3390/toxics8040090

House, J. S., & Motsinger-Reif, A. A. (2020). Fibrate pharmacogenomics: Expanding past the genome. Pharmacogenomics, 21(4), 293–306. https://doi.org/10.2217/pgs-2019-0140

House, J. S., Bouzos, E., Fahy, K. M., Francisco, V. M., Lloyd, D. T., Wright, F. A., … Wheeler, K. E. (2020). Low-Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells. SMALL, 16(21). https://doi.org/10.1002/smll.202000299

Marvel, S. W., House, J. S., Wheeler, M., Song, K., Zhou, Y., Wright, F. A., … Reif, D. M. (2020). The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring county-level vulnerability using visualization, statistical modeling, and machine learning. MedRxiv, Vol. 8. https://doi.org/10.1101/2020.08.10.20169649

Sakolish, C., House, J. S., Chramiec, A., Liu, Y., Chen, Z., Halligan, S. P., … Rusyn, I. (2020). Tissue-Engineered Bone Tumor as a Reproducible Human in Vitro Model for Studies of Anticancer Drugs. TOXICOLOGICAL SCIENCES, 173(1), 65–76. https://doi.org/10.1093/toxsci/kfz220

Tam, H. W., Hall, J. R., Messenger, Z. J., Jima, D. D., House, J. S., Linder, K., & Smart, R. C. (2019). C/EBP beta suppresses keratinocyte autonomous type 1 IFN response and p53 to increase cell survival and susceptibility to UVB-induced skin cancer. CARCINOGENESIS, 40(9), 1099–1109. https://doi.org/10.1093/carcin/bgz012

House, J. S., Hall, J., Park, S. S., Planchart, A., Money, E., Maguire, R. L., … Hoyo, C. (2019). Cadmium exposure and MEG3 methylation differences between Whites and African Americans in the NEST Cohort. Environmental Epigenetics, 5(3). https://doi.org/10.1093/eep/dvz014

Onel, M., Beykal, B., Ferguson, K., Chiu, W. A., McDonald, T. J., Zhou, L., … Pistikopoulos, E. N. (2019). Grouping of complex substances using analytical chemistry data: A framework for quantitative evaluation and visualization. PLOS ONE, 14(10). https://doi.org/10.1371/journal.pone.0223517

Grimm, F. A., House, J. S., Wilson, M. R., Sirenko, O., Iwata, Y., Wright, F. A., … Rusyn, I. (2019). Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers. REGULATORY TOXICOLOGY AND PHARMACOLOGY, 101, 91–102. https://doi.org/10.1016/j.yrtph.2018.11.011

Sai, K., Parsons, C., House, J. S., Kathariou, S., & Ninomiya-Tsuji, J. (2019). Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing. JOURNAL OF CELL BIOLOGY, 218(6), 1994–2005. https://doi.org/10.1083/jcb.201810014

Henriquez, A. R., House, J. S., Snow, S. J., Miller, C. N., Schladweiler, M. C., Fisher, A., … Kodavanti, U. P. (2019). Ozone-Induced Dysregulation of Neuroendocrine Axes Requires Adrenal-Derived Stress Hormones. TOXICOLOGICAL SCIENCES, 172(1), 38–50. https://doi.org/10.1093/toxsci/kfz182

Burnett, S. D., Blanchette, A. D., Grimm, F. A., House, J. S., Reif, D. M., Wright, F. A., … Rusyn, I. (2019). Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes. Toxicology and Applied Pharmacology, 381. https://doi.org/10.1016/j.taap.2019.114711

Grimm, F. A., Blanchette, A., House, J. S., Ferguson, K., Hsieh, N.-H., Dalaijamts, C., … Rusyn, I. (2018). A Human Population-Based Organotypic In Vitro Model for Cardiotoxicity Screening. ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION, 35(4), 441–452. https://doi.org/10.14573/altex.1805301

Messenger, Z. J., Hall, J. R., Jima, D. D., House, J. S., Tam, H. W., Tokarz, D. A., & Smart, R. C. (2018). C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event. Cell Death & Disease, 9(11). https://doi.org/10.1038/s41419-018-1103-y

House, J. S., Mendez, M., Maguire, R. L., Gonzalez-Nahm, S., Huang, Z., Daniels, J., … Hoyo, C. (2018). Periconceptional maternal mediterranean diet is associated with favorable offspring behaviors and altered CpG methylation of imprinted genes. Frontiers in Cell and Developmental Biology, 6(SEP), 107. https://doi.org/10.3389/fcell.2018.00107

Venkatratnam, A., House, J. S., Konganti, K., McKenney, C., Threadgill, D. W., Chiu, W. A., … Rusyn, I. (2018). Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse. MAMMALIAN GENOME, 29(1-2), 168–181. https://doi.org/10.1007/s00335-018-9734-y

Sakolish, C., Weber, E. J., Kelly, E. J., Himmelfarb, J., Mouneimne, R., Grimm, F. A., … Rusyn, I. (2018). Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip. SCIENTIFIC REPORTS, 8(1). https://doi.org/10.1038/s41598-018-33099-2

House, J. S., Grimm, F. A., Jima, D. D., Zhou, Y. H., Rusyn, I., & Wright, F. A. (2017). A pipeline for high-throughput concentration response modeling of gene expression for toxicogenomics. Frontiers in Genetics, 8(NOV). https://doi.org/10.3389/fgene.2017.00168

Henriquez, A., House, J., Miller, D. B., Snow, S. J., Fisher, A., Ren, H., … Kodavanti, U. P. (2017). Adrenal-derived stress hormones modulate ozone-induced lung injury and inflammation. TOXICOLOGY AND APPLIED PHARMACOLOGY, 329, 249–258. https://doi.org/10.1016/j.taap.2017.06.009

House, J. S., Wyss, A. B., Hoppin, J. A., Richards, M., Long, S., Umbach, D. M., … S.J. (2017). Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study. Journal of Allergy and Clinical Immunology, 140(1), 249–256.e14. https://doi.org/10.1016/j.jaci.2016.09.036

Wyss, A. B., House, J. S., Hoppin, J. A., Richards, M., Hankinson, J. L., Long, S., … London, S. J. (2017). Raw milk consumption and other early-life farm exposures and adult pulmonary function in the Agricultural Lung Health Study. Thorax, 73(3), 279–282. https://doi.org/10.1136/thoraxjnl-2017-210031

House, J. S., Nichols, C. E., Li, H., Brandenberger, C., Virgincar, R. S., DeGraff, L. M., … London, S. J. (2017). Vagal innervation is required for pulmonary function phenotype in htr4 <sup>–/–</sup> mice. American Journal of Physiology - Lung Cellular and Molecular Physiology, 312(4), L520–L530. https://doi.org/10.1152/ajplung.00495.2016

House, J. S., Li, H., DeGraff, L. M., Flake, G., Zeldin, D. C., & London, S. J. (2015). Genetic variation in HTR4 and lung function: GWAS follow-up in mouse. FASEB Journal, 29(1), 323–335. https://doi.org/10.1096/fj.14-253898

Graves, J. P., Gruzdev, A., Bradbury, J. A., DeGraff, L. M., Li, H., House, J. S., … Zeldin, D. C. (2015). Quantitative Polymerase Chain Reaction Analysis of the Mouse Cyp2j Subfamily: Tissue Distribution and Regulation. Drug Metabolism and Disposition, 43(8), 1169–1180. https://doi.org/10.1124/dmd.115.064139

London, S. J., Gao, W., Gharib, S. A., Hancock, D. B., Wilk, J. B., House, J. S., … J. (2014). ADAM19 and HTR4 variants and pulmonary function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study. Circulation: Cardiovascular Genetics, 7(3), 350–358. https://doi.org/10.1161/circgenetics.113.000066

Thompson, E. A., Zhu, S., Hall, J. R., House, J. S., Ranjan, R., Burr, J. A., … Smart, R. C. (2011). C/EBP alpha Expression Is Downregulated in Human Nonmelanoma Skin Cancers and Inactivation of C/EBP alpha Confers Susceptibility to UVB-Induced Skin Squamous Cell Carcinomas. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 131(6), 1339–1346. https://doi.org/10.1038/jid.2011.31

House, J. S., Zhu, S., Ranjan, R., Linder, K., & Smart, R. C. (2010). C/EBP alpha and C/EBP beta Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin. PLOS ONE, 5(3). https://doi.org/10.1371/journal.pone.0009837

Ewing, S. J., Zhu, S., Zhu, F., House, J. S., & Smart, R. C. (2008). C/EBP beta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf). CELL DEATH AND DIFFERENTIATION, 15(11), 1734–1744. https://doi.org/10.1038/cdd.2008.105