@article{olivry_paps_amalric_2021, title={Transient and reversible reduction of stratum corneum filaggrin degradation products after allergen challenge in experimentally mite-sensitised atopic dogs}, volume={33}, ISSN={["1365-3164"]}, url={https://doi.org/10.1111/vde.13026}, DOI={10.1111/vde.13026}, abstractNote={BackgroundA defective skin barrier occurs in dogs with atopic dermatitis, and there is controversy over whether this defect pre‐exists, or is secondary to allergic inflammation.}, number={1}, journal={VETERINARY DERMATOLOGY}, publisher={Wiley}, author={Olivry, Thierry and Paps, Judy S. and Amalric, Nicolas}, year={2021}, month={Sep} }
 @article{mishra_wheeler_pitake_ding_jiang_fukuyama_paps_ralph_coyne_parkington_et al._2020, title={Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch}, volume={31}, ISSN={["2211-1247"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85082772179&partnerID=MN8TOARS}, DOI={10.1016/j.celrep.2020.03.036}, abstractNote={Chronic allergic itch is a common symptom affecting millions of people and animals, but its pathogenesis is not fully explained. Herein, we show that periostin, abundantly expressed in the skin of patients with atopic dermatitis (AD), induces itch in mice, dogs, and monkeys. We identify the integrin αVβ3 expressed on a subset of sensory neurons as the periostin receptor. Using pharmacological and genetic approaches, we inhibited the function of neuronal integrin αVβ3, which significantly reduces periostin-induced itch in mice. Furthermore, we show that the cytokine TSLP, the application of AD-causing MC903 (calcipotriol), and house dust mites all induce periostin secretion. Finally, we establish that the JAK/STAT pathway is a key regulator of periostin secretion in keratinocytes. Altogether, our results identify a TSLP-periostin reciprocal activation loop that links the skin to the spinal cord via peripheral sensory neurons, and we characterize the non-canonical functional role of an integrin in itch.}, number={1}, journal={CELL REPORTS}, author={Mishra, Santosh K. and Wheeler, Joshua J. and Pitake, Saumitra and Ding, Huiping and Jiang, Changyu and Fukuyama, Tomoki and Paps, Judy S. and Ralph, Patrick and Coyne, Jacob and Parkington, Michelle and et al.}, year={2020}, month={Apr} }
 @article{tamamoto‐mochizuki_paps_olivry_2019, title={Proactive maintenance therapy of canine atopic dermatitis with the anti‐
            IL
            ‐31 lokivetmab. Can a monoclonal antibody blocking a single cytokine prevent allergy flares?}, volume={30}, ISSN={0959-4493 1365-3164}, url={http://dx.doi.org/10.1111/vde.12715}, DOI={10.1111/vde.12715}, abstractNote={BackgroundOnce the signs of canine atopic dermatitis (AD) are controlled, the proactive application of topical glucocorticoids can delay disease flares.}, number={2}, journal={Veterinary Dermatology}, publisher={Wiley}, author={Tamamoto‐Mochizuki, Chie and Paps, Judy S. and Olivry, Thierry}, year={2019}, month={Jan}, pages={98–e26} }
 @article{banovic_olivry_baumer_paps_stahl_rogers_jacob_2018, title={Diluted sodium hypochlorite (bleach) in dogs: antiseptic efficacy, local tolerability and in vitro effect on skin barrier function and inflammation}, volume={29}, ISSN={["1365-3164"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85040710868&partnerID=MN8TOARS}, DOI={10.1111/vde.12487}, abstractNote={BackgroundDiluted sodium hypochlorite represents an inexpensive and widely available topical antiseptic, but there are no tolerability and efficacy data in veterinary dermatology.}, number={1}, journal={VETERINARY DERMATOLOGY}, author={Banovic, Frane and Olivry, Thierry and Baumer, Wolfgang and Paps, Judy and Stahl, Jessica and Rogers, Ana and Jacob, Megan}, year={2018}, month={Feb} }
 @article{widmer_ferrer_favrot_paps_huynh_olivry_2018, title={Glucocorticosteroids and ciclosporin do not significantly impact canine cutaneous microbiota}, volume={14}, ISSN={["1746-6148"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85042404405&partnerID=MN8TOARS}, DOI={10.1186/s12917-018-1370-y}, abstractNote={As prednisone and ciclosporin can have immunosuppressive effects and have been considered potential predisposing factors for skin infections, we investigated the impact of these drugs on the diversity of the cutaneous microbiota, the abundance of Malassezia and infection with Papillomaviruses. Six atopic, asymptomatic Maltese-beagle dogs were treated with ciclosporin for one month and then with prednisone for another month, with a one-month wash-out between treatments. The dogs were sampled on the abdomen and pinna before and after each treatment using a swab. Samples for Papillomavirus detection were obtained with cytobrush sticks. The bacterial microbiota was characterized using 16S amplicon high-throughput sequencing. Malassezia populations were quantified with nested real-time PCR targeting the ribosomal internal transcribed spacer 1. The diversity and composition of cutaneous microbiota was not impacted in a detectable manner by any of the treatments. As observed for the bacterial microbiota, Malassezia populations were not affected by treatment. Three dogs were positive for Papillomavirus at more than one timepoint, but an association with treatment was not apparent. Ciclosporin and prednisone at doses used for the treatment of atopic dermatitis do not impact the canine cutaneous microbiota in a detectable manner.}, number={1}, journal={BMC VETERINARY RESEARCH}, author={Widmer, Giovanni and Ferrer, Lluis and Favrot, Claude and Paps, Judy and Huynh, Kevin and Olivry, Thierry}, year={2018}, month={Feb} }
 @article{paps_baeumer_olivry_2016, title={Development of an Allergen-induced Atopic Itch Model in Dogs: A Preliminary Report}, volume={96}, ISSN={["1651-2057"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84959099997&partnerID=MN8TOARS}, DOI={10.2340/00015555-2243}, number={3}, journal={ACTA DERMATO-VENEREOLOGICA}, author={Paps, Judy S. and Baeumer, Wolfgang and Olivry, Thierry}, year={2016}, pages={400–401} }
 @article{olivry_mayhew_paps_linder_peredo_rajpal_hofland_cote-sierra_2016, title={Early Activation of Th2/Th22 Inflammatory and Pruritogenic Pathways in Acute Canine Atopic Dermatitis Skin Lesions}, volume={136}, ISSN={["1523-1747"]}, url={https://doi.org/10.1016/j.jid.2016.05.117}, DOI={10.1016/j.jid.2016.05.117}, abstractNote={Determining inflammation and itch pathway activation in patients with atopic dermatitis (AD) is fraught with the inability to precisely assess the age of skin lesions, thus affecting the analysis of time-dependent mediators. To characterize inflammatory events occurring during early experimental acute AD lesions, biopsy samples were collected 6, 24, and 48 hours after epicutaneous application of Dermatophagoides farinae house dust mites to sensitized atopic dogs. The skin transcriptome was assessed using a dog-specific microarray and quantitative PCR. Acute canine AD skin lesions had a significant up-regulation of genes encoding T helper (Th) 2 (e.g., IL4, IL5, IL13, IL31, and IL33), Th9 (IL9), and Th22 (IL22) cytokines as well as Th2-promoting chemokines such as CCL5 and CCL17. Proinflammatory (e.g., IL6, LTB, and IL18) cytokines were also up-regulated. Other known pruritogenic pathways were also activated: there was significant up-regulation of genes encoding proteases cathepsin S (CTSS), mast cell chymase (CMA1), tryptase (TPS1) and mastin, neuromedin-B (NMB), nerve growth factor (NGF), and leukotriene-synthesis enzymes (ALOX5, ALOX5AP, and LTA4H). Experimental acute canine house dust mite-induced AD lesions exhibit an activation of innate and adaptive immune responses and pruritogenic pathways similar to those seen in humans with acute AD, thereby validating this model to test innovative therapeutics modalities for this disease.}, number={10}, journal={JOURNAL OF INVESTIGATIVE DERMATOLOGY}, publisher={Elsevier BV}, author={Olivry, Thierry and Mayhew, David and Paps, Judy S. and Linder, Keith E. and Peredo, Carlos and Rajpal, Deepak and Hofland, Hans and Cote-Sierra, Javier}, year={2016}, month={Oct}, pages={1961–1969} }
 @article{pierezan_olivry_paps_lawhon_wu_steiner_suchodolski_hoffmann_2016, title={The skin microbiome in allergen-induced canine atopic dermatitis}, volume={27}, ISSN={["1365-3164"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84980351834&partnerID=MN8TOARS}, DOI={10.1111/vde.12366}, abstractNote={BackgroundStudies focusing on next‐generation sequencing of the bacterial 16S rRNA gene have allowed detailed surveys of skin bacterial populations (microbiota) of the skin.}, number={5}, journal={VETERINARY DERMATOLOGY}, author={Pierezan, Felipe and Olivry, Thierry and Paps, Judith S. and Lawhon, Sara D. and Wu, Jing and Steiner, Jorg M. and Suchodolski, Jan S. and Hoffmann, Aline Rodrigues}, year={2016}, month={Oct}, pages={332-+} }
 @article{olivry_bizikova_paps_dunston_lerner_yosipovitch_2013, title={Cowhage can induce itch in the atopic dog}, volume={22}, ISSN={["1600-0625"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84878344758&partnerID=MN8TOARS}, DOI={10.1111/exd.12158}, abstractNote={Abstract}, number={6}, journal={EXPERIMENTAL DERMATOLOGY}, author={Olivry, Thierry and Bizikova, Petra and Paps, Judy S. and Dunston, Stan and Lerner, Ethan A. and Yosipovitch, Gil}, year={2013}, month={Jun}, pages={435–437} }
 @article{olivry_linder_wang_bizikova_bernstein_dunston_paps_casal_2012, title={Deficient plakophilin-1 expression due to a mutation in PKP1 causes ectodermal dysplasia-skin fragility syndrome in Chesapeake Bay Retriever dogs}, volume={7}, number={2}, journal={PLoS One}, author={Olivry, T. and Linder, K. E. and Wang, P. and Bizikova, P. and Bernstein, J. A. and Dunston, S. M. and Paps, J. S. and Casal, M. L.}, year={2012} }
 @article{stahl_paps_bäumer_olivry_2012, title={Dermatophagoides farinae house dust mite allergen challenges reduce stratum corneum ceramides in an experimental dog model of acute atopic dermatitis}, volume={23}, ISSN={0959-4493}, url={http://dx.doi.org/10.1111/j.1365-3164.2012.01114.x}, DOI={10.1111/j.1365-3164.2012.01114.x}, abstractNote={Background –  Ceramides are essential stratum corneum (SC) lipids and they play a pivotal role in maintaining effective cutaneous barrier function.}, number={6}, journal={Veterinary Dermatology}, publisher={Wiley}, author={Stahl, Jessica and Paps, Judy and Bäumer, Wolfgang and Olivry, Thierry}, year={2012}, month={Nov}, pages={497–e97} }
 @article{olivry_linder_paps_bizikova_dunston_donne_mondoulet_2012, title={Validation of a novel epicutaneous delivery system for patch testing of house dust mite-hypersensitive dogs}, volume={23}, number={6}, journal={Veterinary Dermatology}, author={Olivry, T. and Linder, K. E. and Paps, J. S. and Bizikova, P. and Dunston, S. and Donne, N. and Mondoulet, L.}, year={2012} }
 @misc{olivry_paps_2011, title={Evaluation of the agreement between allergen-specific intradermal or IgE serological tests and a point-of-care immunodot assay in dogs with atopic dermatitis}, volume={22}, ISSN={["0959-4493"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-79955646421&partnerID=MN8TOARS}, DOI={10.1111/j.1365-3164.2010.00936.x}, abstractNote={Veterinary DermatologyVolume 22, Issue 3 p. 284-285 Letter to the Editor Evaluation of the agreement between allergen-specific intradermal or IgE serological tests and a point-of-care immunodot assay in dogs with atopic dermatitis Thierry Olivry, Thierry Olivry Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University,Raleigh, NC, USA Center for Comparative Medicine and Translational Research, North Carolina State University,Raleigh, NC, USASearch for more papers by this authorJudy Paps, Judy Paps Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University,Raleigh, NC, USASearch for more papers by this author Thierry Olivry, Thierry Olivry Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University,Raleigh, NC, USA Center for Comparative Medicine and Translational Research, North Carolina State University,Raleigh, NC, USASearch for more papers by this authorJudy Paps, Judy Paps Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University,Raleigh, NC, USASearch for more papers by this author First published: 11 November 2010 https://doi.org/10.1111/j.1365-3164.2010.00936.xCitations: 6 Thierry Olivry, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA. E-mail: [email protected] Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL No abstract is available for this article.Citing Literature Volume22, Issue3June 2011Pages 284-285 RelatedInformation}, number={3}, journal={VETERINARY DERMATOLOGY}, author={Olivry, Thierry and Paps, Judy}, year={2011}, month={Jun}, pages={284–285} }
 @article{baeumer_stahl_sander_petersen_paps_stark_kietzmann_olivry_2011, title={Lack of preventing effect of systemically and topically administered histamine H-1 or H-4 receptor antagonists in a dog model of acute atopic dermatitis}, volume={20}, ISSN={["0906-6705"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-79959528878&partnerID=MN8TOARS}, DOI={10.1111/j.1600-0625.2011.01268.x}, abstractNote={Abstract:}, number={7}, journal={EXPERIMENTAL DERMATOLOGY}, author={Baeumer, Wolfgang and Stahl, Jessica and Sander, Kerstin and Petersen, Lars J. and Paps, Judy and Stark, Holger and Kietzmann, Manfred and Olivry, Thierry}, year={2011}, month={Jul}, pages={577–581} }
 @article{olivry_wofford_paps_dunston_2011, title={Stratum corneum removal facilitates experimental sensitization to mite allergens in atopic dogs}, volume={22}, ISSN={["1365-3164"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-79952348135&partnerID=MN8TOARS}, DOI={10.1111/j.1365-3164.2010.00938.x}, abstractNote={Abstract}, number={2}, journal={VETERINARY DERMATOLOGY}, author={Olivry, Thierry and Wofford, Jessica and Paps, Judy S. and Dunston, Stanley M.}, year={2011}, month={Apr}, pages={188–196} }
 @article{ricci_hammerberg_paps_contiero_jackson_2010, title={A comparison of the clinical manifestations of feeding whole and hydrolysed chicken to dogs with hypersensitivity to the native protein}, volume={21}, ISSN={["1365-3164"]}, DOI={10.1111/j.1365-3164.2010.00871.x}, abstractNote={Abstract}, number={4}, journal={VETERINARY DERMATOLOGY}, author={Ricci, Rebecca and Hammerberg, Bruce and Paps, Judy and Contiero, Barbara and Jackson, Hilary}, year={2010}, month={Aug}, pages={358–366} }
 @article{bizikova_linder_paps_olivry_2010, title={Effect of a novel topical diester glucocorticoid spray on immediate- and late-phase cutaneous allergic reactions in Maltese-beagle atopic dogs: a placebo-controlled study}, volume={21}, number={1}, journal={Veterinary Dermatology}, author={Bizikova, P. and Linder, K. E. and Paps, J. and Olivry, T.}, year={2010}, pages={70–79} }
 @article{olivry_kurata_paps_masuda_2007, title={A blinded randomized controlled trial evaluating the usefulness of a novel diet (Aminoprotect Care) in dogs with spontaneous food allergy}, volume={69}, ISSN={["1347-7439"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-36248967710&partnerID=MN8TOARS}, DOI={10.1292/jvms.69.1025}, abstractNote={Aminoprotect Care (APC) is a novel diet composed of aminoacids, potato proteins and corn starch. The objectives of this study were to determine whether Maltese-Beagle atopic (MBA) dogs hypersensitive to corn exhibited clinical signs and changes in immunological markers after being fed APC. The study was designed as a blinded randomized controlled crossover experiment. Ten MBA dogs with signs of allergy within five days of ingesting corn were selected. Dogs were randomized to be fed either their maintenance diet with corn or APC for five days. After a washout of two weeks, diets were switched. Before and daily during each intervention, skin lesions were graded by an investigator while pruritus was assessed by another. Before and at the end of each intervention, the percentage of circulating CD4+CCR4+, corn-activated CD4+ T-lymphocytes and serum corn-specific IgE levels were measured and ratios of post:pre values calculated. During this trial, pruritus and skin lesions increased significantly in MBA dogs when ingesting corn while no such increase occurred when fed APC. Total, median and maximal pruritus values were significantly higher in MBA dogs ingesting corn compared to APC. There were no significant differences between interventions in the immunological parameters assessed. In summary, even though APC contains corn starch to which corn-sensitive MBA dogs often react, the ingestion of APC did not lead to significant increases in skin lesions or pruritus. Aminoprotect Care might prove valuable for management of food allergies. These experimental observations must be validated in large field studies.}, number={10}, journal={JOURNAL OF VETERINARY MEDICAL SCIENCE}, author={Olivry, Thierry and Kurata, Keigo and Paps, Judy S. and Masuda, Kenichi}, year={2007}, month={Oct}, pages={1025–1031} }
 @misc{olivry_paps_bizikova_murphy_jackson_zebala_2007, title={A pilot open trial evaluating the efficacy of low-dose aminopterin in the canine homologue of human atopic dermatitis}, volume={157}, ISSN={["1365-2133"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-35348885050&partnerID=MN8TOARS}, DOI={10.1111/j.1365-2133.2007.08133.x}, abstractNote={SIR, Methotrexate and aminopterin (AMT) are antifolate agents that also exhibit anti-inflammatory effects stemming from several mechanisms that include the extracellular release of adenosine, a potent anti-inflammatory autocoid. Because of such properties, methotrexate has been used in the last decade for treatment of inflammatory conditions such as psoriasis. Results from two open trials suggested that methotrexate benefited human patients with atopic dermatitis (AD). Compared with methotrexate, AMT appears to be more potent and to have a higher bioavailability and lower toxic effects. In this proof-of-concept open two-phase trial, we report the efficacy of AMT in the spontaneous canine model of human AD. In the first phase that lasted 4 weeks, nine dogs with perennial AD diagnosed with conventional methods were given oral AMT 0Æ010 mg kg once weekly. During this phase, subjects did not receive any other interventions outside of weekly antimicrobial shampoos and monthly flea preventatives. Before, and 2 and 4 weeks after beginning AMT, investigators graded skin lesions using the validated Canine Atopic Dermatitis Extent and Severity Index (CADESI). Additionally, owners rated the degree of pruritic manifestations using a 10-point visual analogue scale (PVAS). A global score (GS) combined previous grades as follows: GS = (CADESI · PVAS) ⁄100. At the end of this phase, investigators and owners evaluated subjectively the overall efficacy of AMT using a scale from 0 (no efficacy; < 10% reduction in signs) to 4 (very good efficacy; 75–90% reduction in signs). During the second phase, which could last up to 11 months, dogs received AMT 0Æ010 mg kg once weekly, but this dosage could be increased to 0Æ015 and 0Æ020 mg kg once weekly in case of need. In this extension phase, anti-infectious and ⁄or anti-inflammatory medications were allowed if necessary, and were recorded. Patients were seen monthly and evaluated as above. Weekly during the first month, and every 2–4 weeks thereafter, blood was drawn for full blood counts and serum chemistry panels. Eight of nine dogs completed the 4-week induction phase; one dog (no. 7) was withdrawn because of bacterial folliculitis. CADESI and GS values, but not PVAS numbers, were significantly lower after 4 weeks compared with pretreatment (repeated-measures ANOVA, P < 0Æ05; Fig. 1). After 4 weeks, the median reductions in CADESI, PVAS and GS were 36%, 2Æ8 ⁄10 points and 62%, respectively. At that time, a ‡ 50% reduction from baseline CADESI and GS values was achieved in three of eight and six of eight dogs, respectively (Table 1), and the overall efficacy rating was 2Æ2, a value slightly above the ‘fair efficacy; 25–50% reduction’ mark. Seven dogs continued to receive AMT for up to 40 weeks. One dog (no. 5) was withdrawn after 8 weeks because of lack of efficacy despite doubling the dosage of AMT. Altogether, six of seven dogs (86%) achieved a ‡ 80% reduction in baseline GS values at one time point during the extension phase (Tables 1 and 2), and the disease neared or was in complete Fig 1. Evolution of global scores over 4 weeks in nine dogs treated with aminopterin. In the upper panel, each line corresponds to a different patient. In the lower panel, boxes correspond to the 95% confidence interval, the line is the median and the whiskers highlight the range of values. CADESI, Canine Atopic Dermatitis Extent and Severity Index; PVAS, pruritus visual analogue scale.}, number={5}, journal={BRITISH JOURNAL OF DERMATOLOGY}, author={Olivry, T. and Paps, J. S. and Bizikova, P. and Murphy, K. M. and Jackson, H. A. and Zebala, J.}, year={2007}, month={Nov}, pages={1040–1042} }
 @article{tater_jackson_paps_hammerberg_2005, title={Effects of routine prophylactic vaccination or administration of aluminum adjuvant alone on allergen-specific serum IgE and IgG responses in allergic dogs}, volume={66}, ISSN={["0002-9645"]}, DOI={10.2460/ajvr.2005.66.1572}, abstractNote={Abstract}, number={9}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Tater, KC and Jackson, HA and Paps, J and Hammerberg, B}, year={2005}, month={Sep}, pages={1572–1577} }