Works (9)

Updated: July 5th, 2023 15:55

2009 journal article

Atmospheric pressure infrared (10.6 mu m) laser desorption electrospray ionization (IR-LDESI) coupled to a LTQ Fourier transform ion cyclotron resonance mass spectrometer

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 23(13), 1989–1992.

By: J. Sampson n & D. Muddiman n

MeSH headings : Animals; Cattle; Molecular Weight; Proteins / chemistry; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectroscopy, Fourier Transform Infrared / instrumentation; Spectroscopy, Fourier Transform Infrared / methods
TL;DR: The implementation of a CO(2) laser emitting infrared laser irradiation at 10.6 microm onto the versatile atmospheric pressure ionization platform is presented and Multiply charged proteins ranging in molecular mass from 8.6 to 17 kDa were detected from liquid-state samples without the addition of matrix. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Generation of Multiply Charged Peptides and Proteins by Radio Frequency Acoustic Desorption and Ionization for Mass Spectrometric Detection

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 20(4), 597–600.

By: R. Dixon n, J. Sampson n & D. Muddiman n

MeSH headings : Electrodes; Equipment Design; Mass Spectrometry / instrumentation; Mass Spectrometry / methods; Natriuretic Peptide, Brain / chemistry; Peptides / chemistry; Proteins / chemistry; Quartz / chemistry; Ubiquitin / chemistry
TL;DR: The design and implementation of a radio frequency acoustic desorption ionization (RADIO) source has been demonstrated and intact and dissociated species observed during MS and MS/MS experiments, respectively are confirmed. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Intact and Top-Down Characterization of Biomolecules and Direct Analysis Using Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Coupled to FT-ICR, Mass Spectrometry

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 20(4), 667–673.

By: J. Sampson n, K. Murray* & D. Muddiman n

MeSH headings : Amino Acid Sequence; Animals; Carbohydrates / chemistry; Cattle; Chickens; Egg Yolk / chemistry; Horses; Lipids / chemistry; Milk / chemistry; Molecular Sequence Data; Mucins / chemistry; Mucins / metabolism; Myoglobin / chemistry; Polysaccharides / chemistry; Polysaccharides / metabolism; Proteins / chemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods
TL;DR: Three of the four classes of biological macromolecules have been ionized and detected using MALDESI with minimal sample preparation and Sequencing of O-linked glycans, cleaved from mucin using reductive β-elimination chemistry, is also demonstrated. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Tandem Mass Spectrometry of Thiolate-Protected Au Nanoparticles NaxAu25(SC2H4Ph)(18-y)(S(C2H4O)(5)CH3)(y)

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131(38), 13844–13851.

By: C. Fields-Zinna n, J. Sampson n, M. Crowe n, J. Tracy n, J. Parker n, A. deNey n, D. Muddiman n, R. Murray n

Contributors: C. Fields Zinna n, J. Sampson n, M. Crowe n, J. Tracy n, J. Parker n, A. Deney n, D. Muddiman n, R. Murray n

MeSH headings : Crystallography, X-Ray; Gold / chemistry; Metal Nanoparticles / chemistry; Sulfhydryl Compounds / chemistry; Tandem Mass Spectrometry
TL;DR: The first collision-induced dissociation tandem mass spectrometry (CID MS/MS) of a thiolate-protected Au nanoparticle that has a crystallographically determined structure is reported, and previously unreported results show that even soft ionization sources can result in Au nanoparticles fragmentation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Ambient aerodynamic ionization source for remote analyte sampling and mass spectrometric analysis

ANALYTICAL CHEMISTRY, 80(13), 5266–5271.

By: R. Dixon n, J. Sampson n, A. Hawkridge n & D. Muddiman n

MeSH headings : Acetaminophen / antagonists & inhibitors; Acetaminophen / chemistry; Caffeine / analysis; Caffeine / chemistry; Natriuretic Peptide, Brain / analysis; Natriuretic Peptide, Brain / chemistry; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Ubiquitin / analysis; Ubiquitin / chemistry
TL;DR: This novel aerodynamic device, herein termed remote analyte sampling, transport, and ionization relay (RASTIR) was used to remotely sample neutral species in the ambient and entrain them into an electrospray plume where they were subsequently ionized and detected using a linear ion trap Fourier transform mass spectrometer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Construction of a versatile high precision ambient Ionization source for direct analysis and imaging

Journal of the American Society for Mass Spectrometry, 19(10), 1527–1534.

By: J. Sampson n, A. Hawkridge n & D. Muddiman n

MeSH headings : Bradykinin / chemistry; Cations / chemistry; Humans; Lasers; Melitten / chemistry; Muramidase / chemistry; Myoglobin / chemistry; Spectrometry, Mass, Electrospray Ionization / instrumentation; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Ubiquitin / chemistry
TL;DR: The design and construction of a high precision ambient ionization source matrix-assisted laser desorption electrospray ionization (MALDESI) and the computer controlled high precision motion control system and high repetition rate Explorer laser are demonstrated during MALDESI-FT-ICR analysis. (via Semantic Scholar)
Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2008 journal article

Development and characterization of an ionization technique for analysis of biological macromolecules: Liquid matrix-assisted laser desorption electrospray ionization

ANALYTICAL CHEMISTRY, 80(17), 6773–6778.

By: J. Sampson n, A. Hawkridge n & D. Muddiman n

MeSH headings : Organic Chemicals / chemistry; Peptides / analysis; Proteins / analysis; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Surface Properties
TL;DR: An increase in ion abundance and a concurrent decrease in surface tension with an increase in the applied potential are demonstrated and a singly charged radical cation of an electrochemically active species indicating oxidation occurs for analytes and therefore water is observed. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2007 journal article

Direct characterization of intact polypeptides by matrix-assisted laser desorption electrospray ionization quadrupole Fourier transform ion cyclotron resonance mass spectrometry

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 21(7), 1150–1154.

By: J. Sampson n, A. Hawkridge n & D. Muddiman n

MeSH headings : Cyclotrons; Microchemistry / methods; Molecular Weight; Peptides / chemistry; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods
TL;DR: The ability of MALDESI-QFT-ICR MS to directly analyze and provide high mass measurement accuracy (approximately 1 part-per-million) of a polypeptide using internal calibration is demonstrated and the potential of this system for the top-down characterization of multiply charged polyPEptide cations is shown. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2006 journal article

Generation and detection of multiply-charged peptides and proteins by matrix-assisted laser desorption electrospray ionization (MALDESI) Fourier transform ion cyclotron resonance mass spectrometry

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 17(12), 1712–1716.

By: J. Sampson n, A. Hawkridge n & D. Muddiman n

MeSH headings : Algorithms; Cyclotrons; Peptide Mapping / methods; Peptides / analysis; Proteins / analysis; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Spectroscopy, Fourier Transform Infrared / methods; Static Electricity
TL;DR: Analysis of peptides and proteins resulted in high resolving power single-acquisition FT-ICR mass spectra with average charge-states highly correlated to those obtained by nanoESI, thus, providing strong evidence that the ESI process dictates the observed charge-state distribution. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

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