Johnny T. Ottesen

Works (4)

Updated: April 5th, 2024 11:25

2023 journal article

Toward an optimal contraception dosing strategy

PLOS COMPUTATIONAL BIOLOGY, 19(4).

By: B. Gavina *, V. Reyes *, M. Olufsen  n, S. Lenhart* & J. Ottesen*

MeSH headings : Female; Humans; Progesterone / pharmacology; Luteinizing Hormone; Estradiol; Anovulation; Estrogens; Contraception
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Source: Web Of Science
Added: May 22, 2023

2022 journal article

Postural orthostatic tachycardia syndrome explained using a baroreflex response model

JOURNAL OF THE ROYAL SOCIETY INTERFACE, 19(193).

By: J. Geddes n, J. Ottesen*, J. Mehlsen * & M. Olufsen n

author keywords: POTS; baroreflex; autonomic dysfunction; head-up tilt; mathematical modelling
MeSH headings : Baroreflex / physiology; Blood Pressure / physiology; Heart Rate / physiology; Humans; Postural Orthostatic Tachycardia Syndrome; Posture / physiology
TL;DR: It is demonstrated that modulation of parameters characterizing BR sensitivity allows us to predict the persistent increase in HR and the low-frequency BP and HR oscillations observed in POTS patients and that it is possible to simulate patients with neuropathic and hyperadrenergic POTS. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: September 12, 2022

2019 journal article

Cardiovascular dynamics during head-up tilt assessed via pulsatile and non-pulsatile models

Journal of Mathematical Biology, 79(3), 987–1014.

By: N. Williams*, R. Brady *, S. Gilmore  n, P. Gremaud n, H. Tran n , J. Ottesen*, J. Mehlsen *, M. Olufsen n

author keywords: Cardiovascular dynamics modeling; Head-up tilt; Pulsatile versus non-pulsatile modeling; Parameter estimation; Orthostatic intolerance
MeSH headings : Adult; Blood Pressure; Cardiac Output / physiology; Heart Rate; Hemodynamics; Humans; Male; Models, Cardiovascular; Pulsatile Flow; Supine Position; Tilt-Table Test; Vascular Resistance / physiology
TL;DR: It is shown that mathematical modeling can be used to predict changes in cardiac contractility, vascular resistance, and arterial compliance, quantities that cannot be measured but are useful to assess the system’s state. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 19, 2019

2019 article

Parameter subset selection techniques for problems in mathematical biology

Olsen, C. H., Ottesen, J. T., Smith, R. C., & Olufsen, M. S. (2019, April). BIOLOGICAL CYBERNETICS, Vol. 113, pp. 121–138.

By: C. Olsen n, J. Ottesen*, R. Smith n  & M. Olufsen n

author keywords: Parameter identifiability; Parameter subset selection; Parameter estimation; Modeling
MeSH headings : Algorithms; Blood Circulation; Blood Pressure; Computational Biology; Humans; Models, Biological; Models, Theoretical; Nonlinear Dynamics
TL;DR: This study demonstrates that methods based on local sensitivities are preferable in terms of computational cost and model fit when good initial parameter values are available, but that global methods should be considered when initial parameter value is not known or poorly understood. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

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