Jun Ninomiya-Tsuji

Also known as: Jun Tsuji

TAK1, MAP3K7, inflammatory signaling

Works (113)

Updated: March 4th, 2026 05:06

2025 article

TAK1 inhibition activates pore-forming proteins to block intracellular bacterial growth through modulating mitochondria

López-Pérez, W., González-Calderón, R. E., Sai, K., Rai, P., MacStudy, J. M., Sakamachi, Y., … Ninomiya-Tsuji, J. (2025, June 18). Cell Death and Disease, Vol. 16.

By: W. López-Pérez  n, R. González-Calderón n, K. Sai n, P. Rai *, J. MacStudy n, Y. Sakamachi n, C. Parsons n, S. Kathariou n, M. Fessler *, J. Ninomiya-Tsuji* 

MeSH headings : MAP Kinase Kinase Kinases / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / genetics; Mitochondria / metabolism; Mitochondria / drug effects; Reactive Oxygen Species / metabolism; Humans; Animals; Mice; Apoptosis; Necroptosis; Pyroptosis; Signal Transduction
topics (OpenAlex): Inflammasome and immune disorders; Cell death mechanisms and regulation
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 18, 2025

2024 article

Abstract 1191 TAK1 inhibition translocates pore-forming proteins, MLKL and gasdermins into mitochondria to generate reactive oxygen species

Gonzalez-Calderon, R., Lopez-Perez, W., Sai, K., & Ninomiya-Tsuji, J. (2024, March 1). Journal of Biological Chemistry, Vol. 300, pp. S555–S555.

By: R. Gonzalez-Calderon n, W. Lopez-Perez  n, K. Sai n & J. Ninomiya-Tsuji n 

topics (OpenAlex): RNA regulation and disease; interferon and immune responses
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2024

2024 article

Abstract 1192 The Mechanism and Roles of TAK1 hyperactivation in the Alzheimer's Disease Mouse Model

Nakanishi-Hester, A., Sai, K., & Ninomiya-Tsuji, J. (2024, March 1). Journal of Biological Chemistry, Vol. 300, pp. S556–S556.

By: A. Nakanishi-Hester n , K. Sai n & J. Ninomiya-Tsuji n 

topics (OpenAlex): Retinoids in leukemia and cellular processes
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2024

2024 article

Modulation of iron metabolism by new chemicals interacting with the iron regulatory system

Tsuji, Y., Ninomiya-Tsuji, J., Shen, M. Y. F., & DiFrancesco, B. R. (2024, November 29). Redox Biology, Vol. 79.

By: Y. Tsuji n , J. Ninomiya-Tsuji n , M. Shen* & B. DiFrancesco*

author keywords: Iron metabolism; IRP2; Reactive oxygen species; Oxidative stress; Ferritin; Transferrin receptor
MeSH headings : Humans; Iron / metabolism; Receptors, Transferrin / metabolism; Receptors, Transferrin / genetics; Reactive Oxygen Species / metabolism; Iron Regulatory Protein 2 / metabolism; Iron Regulatory Protein 2 / genetics; Ferritins / metabolism; Ferritins / genetics; Mitochondria / metabolism; Mitochondria / drug effects; Ferroptosis / drug effects; Ferroptosis / genetics; Iron-Regulatory Proteins / metabolism; Iron-Regulatory Proteins / genetics; Antigens, CD
topics (OpenAlex): Iron Metabolism and Disorders; Chromium effects and bioremediation; Radioactive element chemistry and processing
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Sources: Web Of Science, NC State University Libraries
Added: January 13, 2025

2023 article

Aberrantly activated TAK1 links neuroinflammation and neuronal loss in Alzheimer's disease mouse models

Sai, K., Nakanishi, A., Scofield, K. M., Tokarz, D. A., Linder, K. E., Cohen, T. J., & Ninomiya-Tsuji, J. (2023, March 13). Journal of Cell Science, Vol. 136.

By: K. Sai n, A. Nakanishi n , K. Scofield n, D. Tokarz n, K. Linder n, T. Cohen *, J. Ninomiya-Tsuji n 

author keywords: Alzheimer?s disease; Cell death; Inflammation; TAK1
MeSH headings : Animals; Mice; Alzheimer Disease / genetics; Calcium; Cytokines / metabolism; Neuroinflammatory Diseases; Signal Transduction / physiology
topics (OpenAlex): Neuroinflammation and Neurodegeneration Mechanisms; Alzheimer's disease research and treatments; Medicinal Plants and Neuroprotection
TL;DR: It is reported that compound stimulation with the neurotoxic factors TNF and glutamate aberrantly activates neuronal TAK1 (also known as MAP3K7), which promotes the pathogenesis of AD in mouse models and provides a molecular mechanism linking cytokines, Ca2+ signaling and neuronal necroptosis in AD. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 30, 2023

2021 article

TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization

López-Pérez, W., Sai, K., Sakamachi, Y., Parsons, C., Kathariou, S., & Ninomiya-Tsuji, J. (2021, June 14). Proceedings of the National Academy of Sciences, Vol. 118.

By: W. López-Pérez n, K. Sai n, Y. Sakamachi n, C. Parsons n, S. Kathariou n & J. Ninomiya-Tsuji n 

Contributors: W. López-Pérez n, K. Sai n, Y. Sakamachi n, C. Parsons n, S. Kathariou n & J. Ninomiya-Tsuji n 

author keywords: TAK1; ROS; mitochondria; intracellular bacteria
MeSH headings : Animals; Bacteria / growth & development; Caspase 3 / metabolism; Colony Count, Microbial; Hydrogen Sulfide / pharmacology; Intracellular Space / microbiology; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Mice; Mitochondria / metabolism; Reactive Oxygen Species / metabolism; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Salmonella / drug effects; Salmonella / growth & development; Yersinia / drug effects
topics (OpenAlex): Yersinia bacterium, plague, ectoparasites research; Immune Response and Inflammation; Vibrio bacteria research studies
TL;DR: A previously unrecognized host defense mechanism is revealed, which is initiated by host recognition of pathogen-induced impairment in a host protein, TAK1, but not directly of pathogens. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 12, 2021

2019 article

Coordinating Tissue Regeneration Through Transforming Growth Factor-β Activated Kinase 1 Inactivation and Reactivation

Hsieh, H. H. S., Agarwal, S., Cholok, D. J., Loder, S. J., Kaneko, K., Huber, A., … Levi, B. (2019, February 20). Stem Cells, Vol. 37, pp. 766–778.

By: H. Hsieh *, S. Agarwal *, D. Cholok *, S. Loder *, K. Kaneko *, A. Huber *, M. Chung *, K. Ranganathan * ...

Contributors: H. Hsieh *, S. Agarwal *, D. Cholok *, S. Loder *, K. Kaneko *, A. Huber *, M. Chung *, K. Ranganathan * ...

author keywords: Cellular proliferation; Differentiation; Progenitor cells; Proliferation; Stem; progenitor cell; Tissue regeneration
MeSH headings : Animals; Bone Regeneration / drug effects; Bone Regeneration / genetics; Cell Differentiation / drug effects; Cell Proliferation / drug effects; DNA Nucleotidyltransferases / genetics; DNA Nucleotidyltransferases / metabolism; Female; Founder Effect; Fractures, Bone / drug therapy; Fractures, Bone / enzymology; Fractures, Bone / genetics; Fractures, Bone / pathology; Gene Expression Regulation; Integrases / genetics; Integrases / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / genetics; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / enzymology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Osteoblasts / cytology; Osteoblasts / drug effects; Osteoblasts / enzymology; Primary Cell Culture; Protein Kinase Inhibitors / pharmacology; Signal Transduction; Skull / drug effects; Skull / injuries; Skull / metabolism; Wound Healing / drug effects; Wound Healing / genetics
topics (OpenAlex): Heterotopic Ossification and Related Conditions; Biomedical Ethics and Regulation
TL;DR: It is demonstrated that loss of transforming growth factor‐β activated kinase 1 (TAK1) signaling reduces inappropriate tissue formation (heterotopic ossification) through reduced cellular differentiation, and the importance of both the “drug on” and "drug off" states during regenerative therapy is revealed. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 22, 2019

2019 article

Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing

Sai, K., Parsons, C., House, J. S., Kathariou, S., & Ninomiya-Tsuji, J. (2019, April 11). The Journal of Cell Biology, Vol. 218, pp. 1994–2005.

By: K. Sai n, C. Parsons n, J. House n , S. Kathariou n & J. Ninomiya-Tsuji n 

Contributors: K. Sai n, C. Parsons n, J. House n , S. Kathariou n & J. Ninomiya-Tsuji n 

MeSH headings : Animals; Female; Humans; Listeria / growth & development; Listeria / immunology; Listeria / metabolism; Listeriosis / metabolism; Listeriosis / microbiology; Listeriosis / pathology; Listeriosis / prevention & control; Mice; Mice, Inbred C57BL; Mice, Knockout; Necroptosis; Protein Kinases / physiology; Receptor-Interacting Protein Serine-Threonine Kinases / genetics; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Receptor-Interacting Protein Serine-Threonine Kinases / physiology
topics (OpenAlex): Cell death mechanisms and regulation; Inflammasome and immune disorders; interferon and immune responses
TL;DR: The RIPK3-MLKL pathway protects epithelial cells from Listeria monocytogenes invasion but does not induce its oligomerization or necroptotic cell death, and instead targets intracellular bacteria and suppresses their replication. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2019

2018 article

Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death

Liu, X., Hayano, S., Pan, H., Inagaki, M., Ninomiya‐Tsuji, J., Sun, H., & Mishina, Y. (2018, February 22). Genesis, Vol. 56.

By: X. Liu *, S. Hayano *, H. Pan*, M. Inagaki n, J. Ninomiya‐Tsuji n , H. Sun *, Y. Mishina *

Contributors: X. Liu *, S. Hayano *, H. Pan*, M. Inagaki n, J. Ninomiya-Tsuji n , H. Sun *, Y. Mishina *

author keywords: apoptosis; facial prominence; MAP kinase; nasal septum; Smad signaling
MeSH headings : Animals; Apoptosis / genetics; Biomarkers; Bone Morphogenetic Protein Receptors, Type I / genetics; Bone Morphogenetic Protein Receptors, Type I / metabolism; Cell Death / genetics; Craniofacial Abnormalities / diagnosis; Craniofacial Abnormalities / genetics; Genetic Association Studies; Genotype; Gestational Age; Immunohistochemistry; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Transgenic; Mutation; Phenotype; Signal Transduction; Smad Proteins / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
topics (OpenAlex): Cleft Lip and Palate Research; Craniofacial Disorders and Treatments; Hedgehog Signaling Pathway Studies; Tumors and Oncological Cases
TL;DR: It is suggested that deletion of Tak1 aggravates the craniofacial deformities of the caBmpr1a mutants by increasing p53 and phospho‐p38 at different stage of embryogenesis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Erratum: Noncanonical cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1

Scientific Reports, 7(1).

By: S. Mihaly n, Y. Sakamachi n, J. Ninomiya-Tsuji n  & S. Morioka  n

topics (OpenAlex): Cell death mechanisms and regulation
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2017 article

Noncanonical cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1

Mihaly, S. R., Sakamachi, Y., Ninomiya-Tsuji, J., & Morioka, S. (2017, June 1). Scientific Reports, Vol. 7.

By: S. Mihaly n, Y. Sakamachi n, J. Ninomiya-Tsuji n  & S. Morioka n

Contributors: S. Mihaly n, Y. Sakamachi n, J. Ninomiya-Tsuji n  & S. Morioka n

topics (OpenAlex): Cell death mechanisms and regulation; Phagocytosis and Immune Regulation
TL;DR: This work identified a previously uncharacterized cell death pathway regulated by TAK1, which is unexpectedly provoked by inhibition of caspase activity and necroptosis cascades and surprisingly found that caspases and RIPK3 inhibitions do not completely suppress cell death in Tak1-deficient cells. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 article

TAK1 regulates resident macrophages by protecting lysosomal integrity

Sakamachi, Y., Morioka, S., Mihaly, S. R., Takaesu, G., Foley, J. F., Fessler, M. B., & Ninomiya-Tsuji, J. (2017, February 9). Cell Death and Disease, Vol. 8.

By: Y. Sakamachi n, S. Morioka n, S. Mihaly n, G. Takaesu  n, J. Foley *, M. Fessler *, J. Ninomiya-Tsuji n 

Contributors: Y. Sakamachi n, S. Morioka n, S. Mihaly n, G. Takaesu  n, J. Foley *, M. Fessler *, J. Ninomiya-Tsuji n 

MeSH headings : Animals; Cell Death / physiology; Cell Survival / physiology; Embryonic Development / physiology; Lung / metabolism; Lysosomes / metabolism; MAP Kinase Kinase Kinases / metabolism; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Protective Agents / metabolism; Receptors, Tumor Necrosis Factor, Type I / metabolism; Signal Transduction / physiology; Thymocytes / physiology; Thymus Gland / metabolism; Toll-Like Receptors / metabolism
topics (OpenAlex): Zebrafish Biomedical Research Applications; Immune Cell Function and Interaction; Immune cells in cancer
TL;DR: The results suggest that autocrine and potentially paracrine TNF kills Tak1-deficient macrophages during development, and reveal that TAK1 signaling maintains proper macrophage populations through protecting lysosomal integrity. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 article

TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1

Hashimoto, K., Simmons, A. N., Kajino-Sakamoto, R., Tsuji, Y., & Ninomiya-Tsuji, J. (2016, June 1). Antioxidants and Redox Signaling, Vol. 25, pp. 953–964.

By: K. Hashimoto n, A. Simmons n, R. Kajino-Sakamoto n, Y. Tsuji n  & J. Ninomiya-Tsuji n 

Contributors: K. Hashimoto n, A. Simmons n, R. Kajino-Sakamoto n, Y. Tsuji n  & J. Ninomiya-Tsuji n 

author keywords: intestine; TAK1; Nrf2; Keap1; p62/SQSTM
MeSH headings : Animals; Antioxidants / metabolism; Cell Line; Gene Expression Regulation; Humans; Intestinal Mucosa / metabolism; Kelch-Like ECH-Associated Protein 1 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Models, Biological; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress; Protein Binding; Proteolysis; Reactive Oxygen Species / metabolism; Sequestosome-1 Protein / metabolism
topics (OpenAlex): Genomics, phytochemicals, and oxidative stress; Glutathione Transferases and Polymorphisms; Plant Stress Responses and Tolerance
TL;DR: The results identify for the first time that TAK1 is a modulator of p62/SQSTM1-dependent Keap1 degradation and maintains the steady state-level of Nrf2, important for homeostatic antioxidant protection in the intestinal epithelium. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 journal article

TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus

Journal of Cell Science, 129(9), 1855–1865.

By: K. Sai n, S. Morioka  n, G. Takaesu  n, N. Muthusamy n, H. Ghashghaei n, H. Hanafusa *, K. Matsumoto *, J. Ninomiya-Tsuji n 

Contributors: K. Sai n, S. Morioka  n, G. Takaesu  n, N. Muthusamy n, H. Ghashghaei n, H. Hanafusa *, K. Matsumoto *, J. Ninomiya-Tsuji n 

author keywords: TAK1; Endoplasmic reticulum stress; Leptin; Hypothalamus; Obesity
MeSH headings : Animals; Dietary Fats / adverse effects; Dietary Fats / pharmacology; Endoplasmic Reticulum Stress; Hyperphagia / chemically induced; Hyperphagia / genetics; Hyperphagia / metabolism; Hyperphagia / pathology; Hypothalamus / metabolism; Hypothalamus / pathology; Leptin / genetics; Leptin / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Obesity / chemically induced; Obesity / genetics; Obesity / metabolism; Obesity / pathology; Sterol Regulatory Element Binding Proteins / genetics; Sterol Regulatory Element Binding Proteins / metabolism
topics (OpenAlex): Endoplasmic Reticulum Stress and Disease; RNA regulation and disease; Pancreatic function and diabetes
TL;DR: It is found that deletion of Tak1 increased ER volume and facilitated ER-stress tolerance in cultured cells, which was mediated by upregulation of sterol-regulatory-element-binding protein (SREBP)-dependent lipogenesis and central nervous system (CNS) deletion upregulated SREBP-target lipogenic genes and blocked ER stress in the hypothalamus. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2016 article

TAK1 regulates Paneth cell integrity partly through blocking necroptosis

Simmons, A. N., Kajino-Sakamoto, R., & Ninomiya-Tsuji, J. (2016, April 14). Cell Death and Disease, Vol. 7.

By: A. Simmons n, R. Kajino-Sakamoto  n & J. Ninomiya-Tsuji n 

Contributors: A. Simmons n, R. Kajino-Sakamoto  n & J. Ninomiya-Tsuji n 

MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Apoptosis / drug effects; Bacteria / drug effects; Bacteria / genetics; DNA, Bacterial / genetics; DNA, Bacterial / metabolism; Intestinal Mucosa / metabolism; Intestines / microbiology; Intestines / pathology; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88 / deficiency; Myeloid Differentiation Factor 88 / genetics; Myeloid Differentiation Factor 88 / metabolism; Necrosis; Paneth Cells / drug effects; Paneth Cells / metabolism; Paneth Cells / pathology; RNA, Messenger / metabolism; Reactive Oxygen Species / metabolism; Real-Time Polymerase Chain Reaction; Receptor-Interacting Protein Serine-Threonine Kinases / genetics; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Signal Transduction; Toll-Like Receptors / metabolism; Up-Regulation
topics (OpenAlex): Cell death mechanisms and regulation; Immune Response and Inflammation
TL;DR: It is found that depletion of gut bacteria or myeloid differentiation factor 88 (Myd88), a mediator of bacteria-derived cell signaling, reduced ROS but did not block Paneth cell loss, suggesting that gut bacteria are the cause of ROS accumulation but bacteria-induced ROS are not the cause. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 article

TAK1 regulates hepatic lipid homeostasis through SREBP

Morioka, S., Sai, K., Omori, E., Ikeda, Y., Matsumoto, K., & Ninomiya-Tsuji, J. (2016, March 14). Oncogene, Vol. 35, pp. 3829–3838.

By: S. Morioka n, K. Sai n, E. Omori n, Y. Ikeda  n, K. Matsumoto * & J. Ninomiya-Tsuji n 

Contributors: S. Morioka n, K. Sai n, E. Omori n, Y. Ikeda  n, K. Matsumoto * & J. Ninomiya-Tsuji n 

MeSH headings : Animals; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / metabolism; Cell Line; Fatty Liver / genetics; Fatty Liver / metabolism; Female; HEK293 Cells; Hep G2 Cells; Hepatocytes / metabolism; Homeostasis; Humans; Immunoblotting; Lipid Metabolism; Liver / metabolism; Liver Neoplasms / genetics; Liver Neoplasms / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Male; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Protein Binding; RNA Interference; Risk Factors; Sterol Regulatory Element Binding Proteins / genetics; Sterol Regulatory Element Binding Proteins / metabolism
topics (OpenAlex): Cholesterol and Lipid Metabolism; Peroxisome Proliferator-Activated Receptors; Drug Transport and Resistance Mechanisms
TL;DR: It is demonstrated that SREBPs are regulated by a previously uncharacterized mechanism through transforming growth factor-β activated kinase 1 (TAK1), a signaling molecule of inflammation, which critically contributes to the maintenance of liver homeostasis to prevent steatosis. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 article

Activated Macrophage Survival Is Coordinated by TAK1 Binding Proteins

Mihaly, S. R., Morioka, S., Ninomiya-Tsuji, J., & Takaesu, G. (2014, April 15). PLoS ONE, Vol. 9.

By: S. Mihaly n, S. Morioka n, J. Ninomiya-Tsuji n  & G. Takaesu  n

Contributors: S. Mihaly n, S. Morioka n, J. Ninomiya-Tsuji n  & G. Takaesu  n

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Cell Death / drug effects; Cell Death / immunology; Cell Survival / genetics; GTPase-Activating Proteins / antagonists & inhibitors; GTPase-Activating Proteins / genetics; GTPase-Activating Proteins / metabolism; Gene Deletion; Lipopolysaccharides / immunology; MAP Kinase Kinase Kinases / genetics; Macrophage Activation / genetics; Macrophage Activation / immunology; Macrophages / immunology; Macrophages / metabolism; Mice; Mice, Knockout
topics (OpenAlex): Immune Response and Inflammation; Immune cells in cancer
TL;DR: It is reported that TGFβ- activated kinase (TAK1) activators, TAK1-binding protein 1 (TAB1) and TAK2, are critical molecules in the regulation of activated macrophage survival, and shows that TAB1 and TAB2 were redundantly involved in LPS-induced Taker1 activation in macrophages. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 article

TAK1 Binding Protein 2 Is Essential for Liver Protection from Stressors

Ikeda, Y., Morioka, S., Matsumoto, K., & Ninomiya-Tsuji, J. (2014, February 3). PLoS ONE, Vol. 9.

By: Y. Ikeda  n, S. Morioka n, K. Matsumoto * & J. Ninomiya-Tsuji n 

Contributors: Y. Ikeda  n, S. Morioka n, K. Matsumoto * & J. Ninomiya-Tsuji n 

MeSH headings : Adaptor Proteins, Signal Transducing / physiology; Alkylating Agents / toxicity; Animals; Apoptosis / drug effects; Blotting, Western; Chemical and Drug Induced Liver Injury / etiology; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / prevention & control; Diethylnitrosamine / toxicity; Electrophoretic Mobility Shift Assay; Female; Hepatocytes / drug effects; Hepatocytes / metabolism; Hepatocytes / pathology; Integrases / metabolism; Lipopolysaccharides / toxicity; MAP Kinase Kinase Kinases / physiology; Male; Mice; Mice, Knockout; Mice, Transgenic; RNA, Messenger / genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction
topics (OpenAlex): interferon and immune responses; Immune Response and Inflammation
TL;DR: It is demonstrated that TAB2 is a sensor of stress conditions in the liver and functions to protect the liver by activating the TAK1 pathway, and a chemical stressor induced greatly exaggerated liver injury in hepatocyte-specific Tab2-deficient mice. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 article

TAK1 control of cell death

Mihaly, S. R., Ninomiya-Tsuji, J., & Morioka, S. (2014, August 22). Cell Death and Differentiation, Vol. 21, pp. 1667–1676.

By: S. Mihaly n, J. Ninomiya-Tsuji n  & S. Morioka n

Contributors: S. Mihaly n, J. Ninomiya-Tsuji n  & S. Morioka n

MeSH headings : Animals; Apoptosis / physiology; Cell Death; Cell Survival; Homeostasis; Humans; MAP Kinase Kinase Kinases / metabolism; Mice; Mitogen-Activated Protein Kinases / metabolism; NF-kappa B / metabolism; Necrosis / metabolism; Signal Transduction
topics (OpenAlex): interferon and immune responses; Cell death mechanisms and regulation
TL;DR: This review summarizes the consequences of TAK1 deficiency in different cell and tissue types from the perspective of cell death and also focuses on the mechanism by which Tak1 complex inhibits or promotes programmed cell death. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2014 journal article

TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation

The Journal of Cell Biology, 204(4), 607–623.

By: S. Morioka  n, P. Broglie  n, E. Omori n, Y. Ikeda  n, G. Takaesu  n, K. Matsumoto *, J. Ninomiya-Tsuji n 

Contributors: S. Morioka  n, P. Broglie  n, Omori, Y. Ikeda  n, G. Takaesu  n, K. Matsumoto *, J. Ninomiya-Tsuji n 

MeSH headings : Adaptor Proteins, Signal Transducing / physiology; Animals; Apoptosis / drug effects; Blotting, Western; Cell Cycle; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / pathology; Flow Cytometry; Humans; Immunoprecipitation; Integrases / metabolism; Lipopolysaccharides / toxicity; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Necrosis; Phosphorylation; RNA, Small Interfering / genetics; Receptor-Interacting Protein Serine-Threonine Kinases / antagonists & inhibitors; Receptor-Interacting Protein Serine-Threonine Kinases / physiology; Signal Transduction; Tumor Necrosis Factor-alpha / pharmacology
topics (OpenAlex): Cell death mechanisms and regulation; Immune Response and Inflammation
TL;DR: Activation of the TAK1 kinase drives RIPK3-dependent necrosis and inhibits apoptosis downstream of TNF-α stimulation. (via Semantic Scholar)
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Sources: Crossref, NC State University Libraries, ORCID
Added: February 24, 2020

2014 article

Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development

Lane, J., Yumoto, K., Azhar, M., Ninomiya-Tsuji, J., Inagaki, M., Hu, Y., … Kaartinen, V. (2014, December 15). Developmental Biology, Vol. 398, pp. 231–241.

By: J. Lane*, K. Yumoto*, M. Azhar *, J. Ninomiya-Tsuji n , M. Inagaki n, Y. Hu*, C. Deng *, J. Kim *, Y. Mishina *, V. Kaartinen *

Contributors: J. Lane*, K. Yumoto*, M. Azhar *, J. Ninomiya-Tsuji n , M. Inagaki n, Y. Hu*, C. Deng *, J. Kim *, Y. Mishina *, V. Kaartinen *

author keywords: TGF-beta 3 signaling; Palatogenesis; Tak1; Smad4; Trim33
MeSH headings : Animals; Apoptosis / genetics; Cell Fusion; Cell Proliferation; Crosses, Genetic; Embryo, Mammalian / metabolism; Enzyme Activation; Epithelial Cells / metabolism; Epithelium / metabolism; Female; Gene Deletion; Gene Expression Regulation, Developmental; MAP Kinase Kinase Kinases / metabolism; Male; Matrix Metalloproteinase 13 / metabolism; Mice, Knockout; Models, Biological; Mutation / genetics; Organ Specificity; Palate / abnormalities; Palate / embryology; Palate / enzymology; Palate / metabolism; Signal Transduction; Smad4 Protein / metabolism; Transcription Factors / metabolism; Transforming Growth Factor beta3 / metabolism
topics (OpenAlex): Cleft Lip and Palate Research; dental development and anomalies; Hedgehog Signaling Pathway Studies
TL;DR: The data reveal added complexity in TGF-β signaling during palatogenesis and demonstrate that functionally redundant pathways involving Smad4, Tak1 and Trim33 regulate palatal epithelial fusion. (via Semantic Scholar)
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Added: August 6, 2018

2013 article

Kinase-Independent Feedback of the TAK1/TAB1 Complex on BCL10 Turnover and NF-κB Activation

Moreno-García, M. E., Sommer, K., Rincon-Arano, H., Brault, M., Ninomiya-Tsuji, J., Matesic, L. E., & Rawlings, D. J. (2013, January 9). Molecular and Cellular Biology, Vol. 33, pp. 1149–1163.

By: M. Moreno-García*, K. Sommer *, H. Rincon-Arano*, M. Brault*, J. Ninomiya-Tsuji n , L. Matesic *, D. Rawlings *

Contributors: M. Moreno-García*, K. Sommer *, H. Rincon-Arano*, M. Brault*, J. Ninomiya-Tsuji n , L. Matesic *, D. Rawlings *

MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Animals; B-Lymphocytes / metabolism; CARD Signaling Adaptor Proteins / metabolism; Cell Line; Chickens; Endosomal Sorting Complexes Required for Transport / metabolism; HEK293 Cells; Humans; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Inbred C57BL; NF-kappa B / metabolism; Protein Kinase C / metabolism; Protein Kinase C beta; Proteolysis; Receptors, Antigen / metabolism; Signal Transduction; T-Lymphocytes / metabolism; Ubiquitin-Protein Ligases / metabolism; Ubiquitination
topics (OpenAlex): Immune Cell Function and Interaction; Immune Response and Inflammation
TL;DR: By directly promoting BCL10 degradation, TAK1 counterbalances NF-κB and JNK signals essential for the activation and survival of lymphocytes and CARMA1-addicted lymphoma types. (via Semantic Scholar)
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Added: August 6, 2018

2013 article

TGF-β-activated Kinase 1 (Tak1) Mediates Agonist-induced Smad Activation and Linker Region Phosphorylation in Embryonic Craniofacial Neural Crest-derived Cells

Yumoto, K., Thomas, P. S., Lane, J., Matsuzaki, K., Inagaki, M., Ninomiya-Tsuji, J., … Kaartinen, V. (2013, April 2). Journal of Biological Chemistry, Vol. 288, pp. 13467–13480.

By: K. Yumoto*, P. Thomas*, J. Lane*, K. Matsuzaki*, M. Inagaki n, J. Ninomiya-Tsuji n , G. Scott*, M. Ray* ...

Contributors: K. Yumoto*, P. Thomas*, J. Lane*, K. Matsuzaki*, M. Inagaki n, J. Ninomiya-Tsuji n , G. Scott*, M. Ray* ...

MeSH headings : Amino Acid Motifs; Animals; Cells, Cultured; Cleft Palate / enzymology; Cleft Palate / genetics; Ectoderm / cytology; Female; Gene Expression Regulation, Developmental; Head / embryology; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / physiology; Male; Mandible / abnormalities; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases / metabolism; Neural Crest / cytology; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases / metabolism; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta / metabolism; Signal Transduction; Smad Proteins / metabolism; Smad Proteins, Receptor-Regulated / metabolism; TGF-beta Superfamily Proteins / physiology; Wnt1 Protein / genetics; Wnt1 Protein / metabolism
topics (OpenAlex): Hedgehog Signaling Pathway Studies; Bone Metabolism and Diseases
TL;DR: It is suggested that in neural crest-derived ecto-mesenchymal cells, Tak1 provides a critical point of intersection in a complex dialogue between the canonical and noncanonical arms of TGF-β superfamily signaling required for normal craniofacial development. (via Semantic Scholar)
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Added: August 6, 2018

2012 journal article

Epithelial transforming growth factor  -activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species

Proceedings of the National Academy of Sciences, 109(9), 3365–3370.

By: E. Omori n, M. Inagaki n, Y. Mishina *, K. Matsumoto * & J. Ninomiya-Tsuji n 

Contributors: E. Omori n, M. Inagaki n, Y. Mishina *, K. Matsumoto * & J. Ninomiya-Tsuji n 

MeSH headings : Adaptor Proteins, Signal Transducing / deficiency; Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Enzyme Activation; Epidermis / enzymology; Epithelial Cells / enzymology; Intestinal Mucosa / enzymology; Keratinocytes / enzymology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; Phenotype; Phosphorylation; Protein Processing, Post-Translational; Reactive Oxygen Species / metabolism; Signal Transduction
topics (OpenAlex): Immune Response and Inflammation; Neutrophil, Myeloperoxidase and Oxidative Mechanisms
TL;DR: It is demonstrated that epithelial TAK1 activity is regulated through two unique, TAB1-dependent basal and TAB2-mediated stimuli-dependent mechanisms, which are dependent on each other. (via Semantic Scholar)
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Sources: Crossref, NC State University Libraries, ORCID
Added: August 28, 2020

2012 journal article

TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms

PLoS ONE, 7(11), e51073.

By: G. Takaesu *, M. Inagaki n, K. Takubo *, Y. Mishina *, P. Hess n , G. Dean  n, A. Yoshimura *, K. Matsumoto * ...

Contributors: G. Takaesu *, M. Inagaki n, K. Takubo *, Y. Mishina *, P. Hess n , G. Dean  n, A. Yoshimura *, K. Matsumoto *, T. Suda *, J. Ninomiya-Tsuji n 

Ed(s): M. Tjwa

MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Animals; Antigens, Surface / metabolism; Bone Marrow Cells / enzymology; Cell Death; Cell Proliferation; Chimerism; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / enzymology; Humans; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Receptors, Tumor Necrosis Factor, Type I / deficiency; Receptors, Tumor Necrosis Factor, Type I / metabolism; Time Factors; Tumor Necrosis Factor-alpha / metabolism
topics (OpenAlex): Hematopoietic Stem Cell Transplantation; Immune Cell Function and Interaction
TL;DR: The results indicate that TAB1- or TAB2-dependent activation of TAK1 is required for maintenance of the hematopoietic system through two mechanisms: one is prevention of TNF-dependent cell death and the other is T NF-independent maintenance of long-term HSC. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2012 article

TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration

Morioka, S., Inagaki, M., Komatsu, Y., Mishina, Y., Matsumoto, K., & Ninomiya-Tsuji, J. (2012, September 13). Blood, Vol. 120, pp. 3846–3857.

By: S. Morioka  n, M. Inagaki n, Y. Komatsu *, Y. Mishina *, K. Matsumoto * & J. Ninomiya-Tsuji n 

Contributors: S. Morioka  n, M. Inagaki n, Y. Komatsu *, Y. Mishina *, K. Matsumoto * & J. Ninomiya-Tsuji n 

MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Animals; Cell Movement / physiology; Cell Survival; Embryo, Mammalian; Endothelial Cells / metabolism; Flow Cytometry; Humans; Immunoblotting; Immunohistochemistry; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Neovascularization, Physiologic / physiology; RNA, Small Interfering; Signal Transduction / physiology; Umbilical Veins
topics (OpenAlex): Cell Adhesion Molecules Research; Angiogenesis and VEGF in Cancer
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Source: ORCID
Added: September 1, 2024

2011 article

Inhibition of autophagy by TAB2 and TAB3

Criollo, A., Niso‐Santano, M., Malik, S. A., Michaud, M., Morselli, E., Mariño, G., … Kroemer, G. (2011, November 11). The EMBO Journal, Vol. 30, pp. 4908–4920.

By: A. Criollo *, M. Niso‐Santano *, S. Malik *, M. Michaud*, E. Morselli *, G. Mariño *, S. Lachkar *, A. Arkhipenko * ...

Contributors: A. Criollo *, M. Niso-Santano *, S. Malik *, M. Michaud*, E. Morselli *, G. Mariño *, S. Lachkar *, A. Arkhipenko * ...

author keywords: Beclin 1 interactome; mTOR; p53; pifithrin alpha; rapamycin; stress response
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Apoptosis Regulatory Proteins / genetics; Apoptosis Regulatory Proteins / metabolism; Autophagy; Beclin-1; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / genetics; Membrane Proteins / metabolism; Protein Structure, Tertiary; Two-Hybrid System Techniques
topics (OpenAlex): Autophagy in Disease and Therapy; Cancer-related gene regulation; Polyamine Metabolism and Applications
TL;DR: The results point to the existence of an autophagy‐stimulatory ‘switch’ whereby TAB2 and TAB3 abandon inhibitory interactions with Beclin 1 to engage in a stimulatory liaison with TAK1. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2011 article

Non-canonical β-catenin degradation mediates reactive oxygen species-induced epidermal cell death

Omori, E., Matsumoto, K., & Ninomiya-Tsuji, J. (2011, March 7). Oncogene, Vol. 30, pp. 3336–3344.

By: E. Omori n, K. Matsumoto * & J. Ninomiya-Tsuji n 

Contributors: E. Omori n, K. Matsumoto * & J. Ninomiya-Tsuji n 

author keywords: apoptosis; beta-catenin; caspase; epidermis; reactive oxygen species
MeSH headings : Animals; Apoptosis / drug effects; Caspases / metabolism; Cell Adhesion / drug effects; Enzyme Activation / drug effects; Epidermal Cells; Epidermis / drug effects; Epidermis / enzymology; Epidermis / metabolism; HEK293 Cells; Humans; Mice; Reactive Oxygen Species / pharmacology; beta Catenin / metabolism
topics (OpenAlex): Ubiquitin and proteasome pathways; Cancer-related gene regulation
TL;DR: Results indicate that a feed-forward loop consisting of ROS, caspases activation and β-catenin degradation induces epidermal cell death. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2010 journal article

Ablation of TAK1 Upregulates Reactive Oxygen Species and Selectively Kills Tumor Cells

Cancer Research, 70(21), 8417–8425.

By: E. Omori n, K. Matsumoto  n, S. Zhu n, R. Smart n  & J. Ninomiya-Tsuji n 

Contributors: E. Omori n, K. Matsumoto  n, S. Zhu n, R. Smart n  & J. Ninomiya-Tsuji n 

MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; Blotting, Western; Carcinogens / toxicity; Cell Proliferation; Gene Deletion; Integrases / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Papilloma / chemically induced; Papilloma / metabolism; Papilloma / pathology; RNA, Messenger / genetics; RNA, Small Interfering / pharmacology; Reactive Oxygen Species / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Up-Regulation
topics (OpenAlex): interferon and immune responses; RNA regulation and disease
TL;DR: TAK1 kinase could be a new and effective molecular target for ROS-based tumor killing and is examined whether ablation of TAK1 in preexisting skin tumors could cause an increase in ROS and result in tumor cell death. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2010 article

Regulation of Genotoxic Stress Response by Homeodomain-interacting Protein Kinase 2 through Phosphorylation of Cyclic AMP Response Element-binding Protein at Serine 271

Sakamoto, K., Huang, B.-W., Iwasaki, K., Hailemariam, K., Ninomiya-Tsuji, J., & Tsuji, Y. (2010, June 24). Molecular Biology of the Cell, Vol. 21, pp. 2966–2974.

By: K. Sakamoto  n, B. Huang  n, K. Iwasaki  n, K. Hailemariam n, J. Ninomiya-Tsuji n  & Y. Tsuji n 

Contributors: K. Sakamoto  n, B. Huang  n, K. Iwasaki  n, K. Hailemariam n, J. Ninomiya-Tsuji n  & Y. Tsuji n 

MeSH headings : Animals; Antineoplastic Agents, Phytogenic / pharmacology; Blotting, Western; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / metabolism; CREB-Binding Protein / genetics; CREB-Binding Protein / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cell Line, Tumor; Cells, Cultured; Cyclic AMP Response Element-Binding Protein / genetics; Cyclic AMP Response Element-Binding Protein / metabolism; DNA Damage; Embryo, Mammalian / cytology; Etoposide / pharmacology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; HEK293 Cells; Humans; K562 Cells; Mice; Mice, Knockout; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; RNA Interference; Serine / genetics; Serine / metabolism; Transcription, Genetic / drug effects; Two-Hybrid System Techniques
topics (OpenAlex): Virus-based gene therapy research; Cancer-related Molecular Pathways; Cell death mechanisms and regulation
TL;DR: Homeodomain-interacting protein kinase 2 is a new CREB kinase for phosphorylation at Ser-271 but not Ser-133 in genotoxic stress and activates CREB transactivation function including brain-derived neurotrophic factor (BDNF) mRNA expression. (via Semantic Scholar)
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Added: August 6, 2018

2010 journal article

TGF-β–Activated Kinase 1 Signaling Maintains Intestinal Integrity by Preventing Accumulation of Reactive Oxygen Species in the Intestinal Epithelium

The Journal of Immunology, 185(8), 4729–4737.

By: R. Kajino-Sakamoto  n, E. Omori n, P. Nighot n, A. Blikslager n , K. Matsumoto * & J. Ninomiya-Tsuji n 

Contributors: R. Kajino-Sakamoto  n, E. Omori n, P. Nighot n, A. Blikslager n , K. Matsumoto * & J. Ninomiya-Tsuji n 

MeSH headings : Animals; Blotting, Western; Epithelium / enzymology; Epithelium / immunology; Gene Expression; Gene Expression Regulation / immunology; Immunity, Mucosal / physiology; Immunohistochemistry; Intestinal Mucosa / enzymology; Intestinal Mucosa / immunology; MAP Kinase Kinase Kinases / immunology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-E2-Related Factor 2 / immunology; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / immunology; Reactive Oxygen Species / immunology; Reactive Oxygen Species / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction
topics (OpenAlex): Helicobacter pylori-related gastroenterology studies; Genomics, phytochemicals, and oxidative stress
TL;DR: It is reported that TGF-β–activated kinase 1 (TAK1) is a key regulator of ROS in the intestinal epithelium and regulates ROS through transcription factor NF-E2–related factor 2, which is important for intestinal epithelial integrity. (via Semantic Scholar)
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Added: August 6, 2018

2009 article

Intestinal Epithelial-Derived TAK1 Signaling Is Essential for Cytoprotection against Chemical-Induced Colitis

Kim, J.-Y., Kajino-Sakamoto, R., Omori, E., Jobin, C., & Ninomiya-Tsuji, J. (2009, February 20). PLoS ONE, Vol. 4.

By: J. Kim n, R. Kajino-Sakamoto n, E. Omori n, C. Jobin * & J. Ninomiya-Tsuji n 

Contributors: J. Kim n, R. Kajino-Sakamoto n, E. Omori n, C. Jobin * & J. Ninomiya-Tsuji n 

MeSH headings : Animals; Apoptosis; Cell Proliferation; Colitis / chemically induced; Colitis / etiology; Cyclooxygenase 2; Dextran Sulfate; Interleukin-6; Intestinal Mucosa / metabolism; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Receptors, Tumor Necrosis Factor, Type I / deficiency; Signal Transduction
topics (OpenAlex): Immune Response and Inflammation; Helicobacter pylori-related gastroenterology studies
TL;DR: It is shown that TAK1 is essential for interleukin 1- and bacterial components-induced expression of cytoprotective factors and cell proliferation, which is pivotal for protecting the intestinal epithelium against injury. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2009 article

TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP

Morioka, S., Omori, E., Kajino, T., Kajino-Sakamoto, R., Matsumoto, K., & Ninomiya-Tsuji, J. (2009, May 4). Oncogene, Vol. 28, pp. 2257–2265.

By: S. Morioka*, E. Omori n, T. Kajino *, R. Kajino-Sakamoto n, K. Matsumoto * & J. Ninomiya-Tsuji n 

Contributors: S. Morioka*, E. Omori n, T. Kajino *, R. Kajino-Sakamoto n, K. Matsumoto * & J. Ninomiya-Tsuji n 

author keywords: TAK1; TRAIL; reactive oxygen species; cIAP; apoptosis
MeSH headings : Animals; Apoptosis / drug effects; Caspase 3 / metabolism; Cell Line; Cell Line, Tumor; Cell Survival / drug effects; Electrophoretic Mobility Shift Assay; Flow Cytometry; HeLa Cells; Humans; Immunoblotting; Inhibitor of Apoptosis Proteins / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Microscopy, Fluorescence; NF-kappa B / metabolism; RNA, Small Interfering / genetics; Reactive Oxygen Species / metabolism; Recombinant Proteins / pharmacology; TNF-Related Apoptosis-Inducing Ligand / genetics; TNF-Related Apoptosis-Inducing Ligand / pharmacology; Transfection
topics (OpenAlex): Cell death mechanisms and regulation; Immune Response and Inflammation
TL;DR: It is reported that deletion of TAK1 kinase greatly increased activation of caspase-3 and cell death after TRAIL stimulation in keratinocytes, fibroblasts and cancer cells, and inhibition of Tak1 can be an effective approach to increase TRAIL sensitivity. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2009 article

Transforming Growth Factor β-activated Kinase 1 (TAK1) Kinase Adaptor, TAK1-binding Protein 2, Plays Dual Roles in TAK1 Signaling by Recruiting Both an Activator and an Inhibitor of TAK1 Kinase in Tumor Necrosis Factor Signaling Pathway

Broglie, P., Matsumoto, K., Akira, S., Brautigan, D. L., & Ninomiya-Tsuji, J. (2009, December 3). Journal of Biological Chemistry, Vol. 285, pp. 2333–2339.

By: P. Broglie n, K. Matsumoto *, S. Akira *, D. Brautigan * & J. Ninomiya-Tsuji n 

Contributors: P. Broglie n, K. Matsumoto *, S. Akira *, D. Brautigan * & J. Ninomiya-Tsuji n 

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Cell Line, Transformed; Dermis / cytology; Fibroblasts / cytology; Fibroblasts / enzymology; Gene Deletion; JNK Mitogen-Activated Protein Kinases / metabolism; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System / drug effects; MAP Kinase Signaling System / physiology; Mice; NF-kappa B / metabolism; Phosphoprotein Phosphatases / metabolism; Phosphorylation / physiology; Tumor Necrosis Factor-alpha / metabolism; Tumor Necrosis Factor-alpha / pharmacology; Ubiquitin / metabolism; Ubiquitination / physiology
topics (OpenAlex): Immune Response and Inflammation; interferon and immune responses
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 journal article

203 TAK1 Is Essential for Intestinal Epithelial Cell Survival and Regulates Intestinal Integrity

Gastroenterology, 134(4), A-35-A-36.

By: R. Kajino-Sakamoto, M. Inagaki, J. Kim, S. Robine, K. Matsumoto, C. Jobin, J. Ninomiya-Tsuji* 

topics (OpenAlex): Inflammatory Bowel Disease; Cancer Immunotherapy and Biomarkers; Metastasis and carcinoma case studies
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2008 article

Enterocyte-Derived TAK1 Signaling Prevents Epithelium Apoptosis and the Development of Ileitis and Colitis

Kajino-Sakamoto, R., Inagaki, M., Lippert, E., Akira, S., Robine, S., Matsumoto, K., … Ninomiya-Tsuji, J. (2008, July 1). The Journal of Immunology, Vol. 181, pp. 1143–1152.

By: R. Kajino-Sakamoto  n, M. Inagaki n, E. Lippert*, S. Akira *, S. Robine *, K. Matsumoto *, C. Jobin *, J. Ninomiya-Tsuji n 

MeSH headings : Animals; Apoptosis; Colitis / immunology; Colitis / metabolism; Enterocytes / cytology; Enterocytes / immunology; Enterocytes / metabolism; Ileitis / immunology; Ileitis / metabolism; Intestinal Mucosa / immunology; Intestinal Mucosa / metabolism; MAP Kinase Kinase Kinases / immunology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Mice, Mutant Strains; Signal Transduction; Tumor Necrosis Factor-alpha / immunology; Tumor Necrosis Factor-alpha / metabolism
topics (OpenAlex): Immune Response and Inflammation; Helicobacter pylori-related gastroenterology studies
TL;DR: Enterocyte apoptosis and intestinal inflammation were strongly attenuated when enterocyte-specific constitutive TAK1-deleted mice were crossed to TNF receptor 1−/− mice, and it is proposed that aberration in Tak1 signaling might disrupt intestinal homeostasis and favor the development of inflammatory disease. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis

Journal of Immunology, 181(2), 1143–1152. http://www.scopus.com/inward/record.url?eid=2-s2.0-49049095991&partnerID=MN8TOARS

By: R. Kajino-Sakamoto, M. Inagaki, E. Lippert, S. Akira, S. Robine, K. Matsumoto, C. Jobin, J. Ninomiya-Tsuji 

Contributors: R. Kajino-Sakamoto, M. Inagaki, E. Lippert, S. Akira, S. Robine, K. Matsumoto, C. Jobin, J. Ninomiya-Tsuji 

www.scopus.com
Source: ORCID
Added: September 1, 2024

2008 article

Generation of a conditional mutant allele for Tab1 in mouse

Inagaki, M., Komatsu, Y., Scott, G., Yamada, Ray, M., Ninomiya‐Tsuji, J., & Mishina, Y. (2008, August 1). Genesis, Vol. 46, pp. 431–439.

By: M. Inagaki n, Y. Komatsu *, G. Scott*, . Yamada *, M. Ray*, J. Ninomiya‐Tsuji n , Y. Mishina *

Contributors: M. Inagaki n, Y. Komatsu *, G. Scott*, G. Yamada *, M. Ray*, J. Ninomiya-Tsuji n , Y. Mishina *

author keywords: conditional gene knockout; MAP kinase; BMP; Tab1; TGF-beta
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Animals; Exons; Gene Targeting; Integrases / metabolism; Mice; Mutation
topics (OpenAlex): Cell Adhesion Molecules Research
TL;DR: It is demonstrated that Cre‐mediated recombination using Sox2‐Cre, a Cre line expressed in the epiblast during early embryogenesis, results in deletion of the gene and protein and homozygous Cre‐recombined null embryos display an identical phenotype to conventional null embryos. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 article

TAB4 Stimulates TAK1-TAB1 Phosphorylation and Binds Polyubiquitin to Direct Signaling to NF-κB

Prickett, T. D., Ninomiya-Tsuji, J., Broglie, P., Muratore-Schroeder, T. L., Shabanowitz, J., Hunt, D. F., & Brautigan, D. L. (2008, May 5). Journal of Biological Chemistry, Vol. 283, pp. 19245–19254.

By: T. Prickett, J. Ninomiya-Tsuji n , P. Broglie n, T. Muratore-Schroeder*, J. Shabanowitz *, D. Hunt *, D. Brautigan *

Contributors: T. Prickett, J. Ninomiya-Tsuji n , P. Broglie n, T. Muratore-Schroeder*, J. Shabanowitz *, D. Hunt *, D. Brautigan *

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Amino Acid Motifs / genetics; Amino Acid Substitution; Humans; I-kappa B Kinase / genetics; I-kappa B Kinase / metabolism; Interleukin-1beta / metabolism; MAP Kinase Kinase 3 / genetics; MAP Kinase Kinase 3 / metabolism; MAP Kinase Kinase 6 / genetics; MAP Kinase Kinase 6 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mutation, Missense; NF-kappa B / genetics; NF-kappa B / metabolism; Phosphorylation; Protein Binding / genetics; Protein Structure, Tertiary / genetics; Signal Transduction / physiology; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Ubiquitin / genetics; Ubiquitin / metabolism; p38 Mitogen-Activated Protein Kinases / genetics; p38 Mitogen-Activated Protein Kinases / metabolism
topics (OpenAlex): interferon and immune responses; Immune Response and Inflammation
TL;DR: The results show that TAB4 binds TAK1 and polyubiquitin chains to promote specific sites of phosphorylation in TAK 1-TAB1, which activates IKK signaling to NF-κB. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 article

TAK1 Regulates Reactive Oxygen Species and Cell Death in Keratinocytes, Which Is Essential for Skin Integrity

Omori, E., Morioka, S., Matsumoto, K., & Ninomiya-Tsuji, J. (2008, July 8). Journal of Biological Chemistry, Vol. 283, pp. 26161–26168.

By: E. Omori n, S. Morioka  n, K. Matsumoto * & J. Ninomiya-Tsuji n 

Contributors: E. Omori n, S. Morioka  n, K. Matsumoto * & J. Ninomiya-Tsuji n 

MeSH headings : Animals; Antioxidants / metabolism; Cytochromes c / metabolism; Gene Expression Regulation; Inflammation; Keratinocytes / cytology; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Transgenic; Models, Biological; NF-kappa B / metabolism; Oxidative Stress; Proto-Oncogene Proteins c-jun / metabolism; Reactive Oxygen Species; Skin / metabolism
topics (OpenAlex): Immune Response and Inflammation; interferon and immune responses
TL;DR: It is shown that, in an in vivo setting, the antioxidant treatment could reduce an inflammatory condition in keratinocyte-specific Tak1 deletion mice and regulate ROS partially through c-Jun, which is important for preventing ROS-induced skin inflammation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2008 article

TAK1-binding Protein 1, TAB1, Mediates Osmotic Stress-induced TAK1 Activation but Is Dispensable for TAK1-mediated Cytokine Signaling

Inagaki, M., Omori, E., Kim, J.-Y., Komatsu, Y., Scott, G., Ray, M. K., … Ninomiya-Tsuji, J. (2008, October 2). Journal of Biological Chemistry, Vol. 283, pp. 33080–33086.

By: M. Inagaki n, E. Omori n, J. Kim n, Y. Komatsu *, G. Scott*, M. Ray*, . Yamada *, K. Matsumoto *, Y. Mishina *, J. Ninomiya-Tsuji n 

Contributors: M. Inagaki n, E. Omori n, J. Kim n, Y. Komatsu *, G. Scott*, M. Ray*, G. Yamada *, K. Matsumoto *, Y. Mishina *, J. Ninomiya-Tsuji n 

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Cell Line; Cytokines / metabolism; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Enzyme Activation / physiology; Fibroblasts / cytology; Fibroblasts / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Osmotic Pressure / physiology; Protein Structure, Tertiary / physiology; Signal Transduction / physiology
topics (OpenAlex): Immune Response and Inflammation; Neutrophil, Myeloperoxidase and Oxidative Mechanisms
TL;DR: It is found that TAK1 is spontaneously activated when the concentration is increased and that it is totally dependent on TAB1, and that the C-terminal 68 amino acids of TAB 1 were sufficient to mediate osmotic stress-induced TAK 1 activation. (via Semantic Scholar)
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Added: August 6, 2018

2007 article

Mitochondrial Dysfunction

Ninomiya‐Tsuji, J. (2007, October 23). Molecular and Biochemical Toxicology, Fourth Edition, pp. 319–332.

By: J. Ninomiya‐Tsuji n 

Contributors: J. Ninomiya-Tsuji n 

topics (OpenAlex): Mitochondrial Function and Pathology; Metabolism and Genetic Disorders
Source: ORCID
Added: September 1, 2024

2007 article

Osmotic stress blocks NF‐κB‐dependent inflammatory responses by inhibiting ubiquitination of IκB

HuangFu, W.-C., Matsumoto, K., & Ninomiya-Tsuji, J. (2007, November 13). FEBS Letters, Vol. 581, pp. 5549–5554.

By: W. HuangFu n, K. Matsumoto * & J. Ninomiya-Tsuji n 

Contributors: W. HuangFu n, K. Matsumoto * & J. Ninomiya-Tsuji n 

author keywords: NF-kappa B; cytokine; osmotic stress; inflammation
MeSH headings : Animals; Cells, Cultured; Humans; I-kappa B Kinase / metabolism; I-kappa B Proteins / antagonists & inhibitors; I-kappa B Proteins / metabolism; Inflammation / metabolism; Interleukin-1 / antagonists & inhibitors; Interleukin-1 / metabolism; Mice; Mice, Inbred C57BL; NF-KappaB Inhibitor alpha; NF-kappa B / antagonists & inhibitors; NF-kappa B / metabolism; Osmotic Pressure; Signal Transduction; Ubiquitination / physiology
topics (OpenAlex): Immune Response and Inflammation; interferon and immune responses
TL;DR: Osmotic stress‐mediated modification of the NF‐κB pathway, a central signaling pathway in inflammation, is investigated and blockage of IκBα ubiquitination is likely to be a major mechanism for inhibition of inflammation by hypertonic conditions. (via Semantic Scholar)
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Added: August 6, 2018

2007 article

TAK1 Is a Central Mediator of NOD2 Signaling in Epidermal Cells

Kim, J.-Y., Omori, E., Matsumoto, K., Núñez, G., & Ninomiya-Tsuji, J. (2007, October 26). Journal of Biological Chemistry, Vol. 283, pp. 137–144.

By: J. Kim n, E. Omori n, K. Matsumoto *, G. Núñez * & J. Ninomiya-Tsuji n 

Contributors: J. Kim n, E. Omori n, K. Matsumoto *, G. Núñez * & J. Ninomiya-Tsuji n 

MeSH headings : Acetylmuramyl-Alanyl-Isoglutamine / pharmacology; Animals; Cell Line; Cell Line, Tumor; Cells, Cultured; Chemokines, CXC / genetics; Chemokines, CXC / metabolism; Electrophoretic Mobility Shift Assay; Humans; Immunity, Innate / drug effects; Immunoblotting; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases / genetics; JNK Mitogen-Activated Protein Kinases / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Mutant Strains; Models, Biological; NF-kappa B / genetics; NF-kappa B / metabolism; Nod2 Signaling Adaptor Protein / genetics; Nod2 Signaling Adaptor Protein / metabolism; Receptor-Interacting Protein Serine-Threonine Kinase 2 / genetics; Receptor-Interacting Protein Serine-Threonine Kinase 2 / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction / drug effects; Transfection; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
topics (OpenAlex): Immune Response and Inflammation; Cell Adhesion Molecules Research
TL;DR: It is shown that transforming growth factor β-activated kinase 1 (TAK1) is an essential intermediate of NOD2 signaling and its ablation may impair the skin barrier function leading to inflammation. (via Semantic Scholar)
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Added: August 6, 2018

2007 article

TAK1 MAPK Kinase Kinase Mediates Transforming Growth Factor-β Signaling by Targeting SnoN Oncoprotein for Degradation

Kajino, T., Omori, E., Ishii, S., Matsumoto, K., & Ninomiya-Tsuji, J. (2007, February 4). Journal of Biological Chemistry, Vol. 282, pp. 9475–9481.

By: T. Kajino *, E. Omori n, S. Ishii, K. Matsumoto * & J. Ninomiya-Tsuji n 

Contributors: T. Kajino *, E. Omori n, S. Ishii, K. Matsumoto * & J. Ninomiya-Tsuji n 

MeSH headings : Cell Line, Transformed; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins / metabolism; MAP Kinase Kinase Kinases / physiology; Phosphorylation; Proto-Oncogene Proteins / metabolism; Signal Transduction / physiology; Transforming Growth Factor beta / physiology
topics (OpenAlex): Bone Metabolism and Diseases
TL;DR: The data suggest that TAK1 modulates TGF-β-dependent cellular responses by targeting SnoN for degradation, and this phosphorylation regulated the stability of SnoN. (via Semantic Scholar)
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Added: August 6, 2018

2006 journal article

Osmotic Stress Activates the TAK1-JNK Pathway While Blocking TAK1-mediated NF-κB Activation

Journal of Biological Chemistry, 281(39), 28802–28810.

By: W. HuangFu  n, E. Omori n, S. Akira *, K. Matsumoto * & J. Ninomiya-Tsuji n 

Contributors: W. HuangFu  n, E. Omori n, S. Akira *, K. Matsumoto * & J. Ninomiya-Tsuji n 

MeSH headings : Animals; Cell Line; Enzyme Activation; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / metabolism; Mice; NF-kappa B / metabolism; Osmosis; Protein Binding; Protein Kinases / chemistry; Protein Kinases / physiology; Protein Serine-Threonine Kinases / physiology; RNA, Small Interfering / metabolism
topics (OpenAlex): Immune Response and Inflammation; Melanoma and MAPK Pathways
TL;DR: It is found that TAK1 is essential for osmotic stress-induced activation of JNK but is not an exclusive mediator of p38 activation, and TAO2 (thousand-and-one amino acid kinase 2) associates with Tak1 and can inhibit TAK 1-mediated activation of NF-κB but not of J NK. (via Semantic Scholar)
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Sources: Crossref, NC State University Libraries, ORCID
Added: August 28, 2020

2006 article

Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappa B activation - TAO2 regulates TAK1 pathways

Journal of Biological Chemistry, Vol. 281, pp. 28802–28810.

By: W. Huangfu, E. Omori, S. Akira, K. Matsumoto & J. Ninomiya-Tsuji 

topics (OpenAlex):
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2006 article

Protein Phosphatase 6 Down-regulates TAK1 Kinase Activation in the IL-1 Signaling Pathway

Kajino, T., Ren, H., Iemura, S.-ichiro, Natsume, T., Stefansson, B., Brautigan, D. L., … Ninomiya-Tsuji, J. (2006, November 2). Journal of Biological Chemistry, Vol. 281, pp. 39891–39896.

By: T. Kajino *, H. Ren *, S. Iemura *, T. Natsume *, B. Stefansson *, D. Brautigan *, K. Matsumoto *, J. Ninomiya-Tsuji n 

Contributors: T. Kajino *, H. Ren *, S. Iemura *, T. Natsume *, B. Stefansson *, D. Brautigan *, K. Matsumoto *, J. Ninomiya-Tsuji n 

MeSH headings : Cells, Cultured; Down-Regulation / drug effects; Down-Regulation / physiology; Enzyme Activation / physiology; Enzyme Inhibitors / pharmacology; Humans; Interleukin-1 / physiology; Isoenzymes / antagonists & inhibitors; Isoenzymes / biosynthesis; Isoenzymes / physiology; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Kinase Kinases / physiology; Phosphoprotein Phosphatases / antagonists & inhibitors; Phosphoprotein Phosphatases / biosynthesis; Phosphoprotein Phosphatases / physiology; Phosphorylation / drug effects; Signal Transduction / drug effects; Signal Transduction / physiology; Up-Regulation / drug effects
topics (OpenAlex): Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Cytokine Signaling Pathways and Interactions
TL;DR: It is found that toxin inhibition of type 2A protein phosphatases greatly enhances interleukin 1 (IL-1)-dependent phosphorylation of Thr-187 in the TAK1 activation loop as well as the catalytic activity of Tak1. (via Semantic Scholar)
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Added: August 6, 2018

2006 article

TAK1 Is a Component of the Epstein-Barr Virus LMP1 Complex and Is Essential for Activation of JNK but Not of NF-κB

Uemura, N., Kajino, T., Sanjo, H., Sato, S., Akira, S., Matsumoto, K., & Ninomiya-Tsuji, J. (2006, January 31). Journal of Biological Chemistry, Vol. 281, pp. 7863–7872.

By: N. Uemura n, T. Kajino *, H. Sanjo *, S. Sato *, S. Akira *, K. Matsumoto *, J. Ninomiya-Tsuji n 

Contributors: N. Uemura n, T. Kajino *, H. Sanjo *, S. Sato *, S. Akira *, K. Matsumoto *, J. Ninomiya-Tsuji n 

MeSH headings : Animals; Cell Line; Cytoplasm / metabolism; Enzyme Activation; Enzyme Inhibitors / pharmacology; Fibroblasts / metabolism; Gene Deletion; Herpesvirus 4, Human / metabolism; Humans; Immunoblotting; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Transgenic; Models, Biological; Mutation; NF-kappa B / metabolism; Plasmids / metabolism; Signal Transduction; TNF Receptor-Associated Factor 6 / metabolism; Transfection; Viral Matrix Proteins / metabolism
topics (OpenAlex): Viral-associated cancers and disorders; Lymphoma Diagnosis and Treatment
TL;DR: Results suggest that an LMP1-associated complex containing TRAF6, TAB2, and TAK1 plays an essential role in the activation of JNK, however, TAK 1 is not an exclusive intermediate for NF-κB activation in L MP1 signaling. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2006 article

TAK1 Is a Master Regulator of Epidermal Homeostasis Involving Skin Inflammation and Apoptosis

Omori, E., Matsumoto, K., Sanjo, H., Sato, S., Akira, S., Smart, R. C., & Ninomiya-Tsuji, J. (2006, May 5). Journal of Biological Chemistry, Vol. 281, pp. 19610–19617.

By: E. Omori n, K. Matsumoto *, H. Sanjo *, S. Sato *, S. Akira *, R. Smart n , J. Ninomiya-Tsuji n 

Contributors: E. Omori n, K. Matsumoto *, H. Sanjo *, S. Sato *, S. Akira *, R. Smart n , J. Ninomiya-Tsuji n 

MeSH headings : Animals; Apoptosis; Cytokines / metabolism; Epidermis / metabolism; Gene Deletion; Homeostasis; Inflammation; Keratinocytes / cytology; Keratinocytes / metabolism; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Inbred C57BL; NF-kappa B / metabolism; Skin / pathology
topics (OpenAlex): Immune Response and Inflammation; Cell Adhesion Molecules Research
TL;DR: It is demonstrated that TAK1 is the major regulator of skin inflammation as well as keratinocyte death in vivo and is a master regulator of TNF signaling in skin and regulates skin inflammation and keratinocytes death. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2006 article

TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells

Sato, S., Sanjo, H., Tsujimura, T., Ninomiya-Tsuji, J., Yamamoto, M., Kawai, T., … Akira, S. (2006, August 7). International Immunology, Vol. 18, pp. 1405–1411.

By: S. Sato *, H. Sanjo, T. Tsujimura, J. Ninomiya-Tsuji , M. Yamamoto, T. Kawai, O. Takeuchi, S. Akira

Contributors: S. Sato *, H. Sanjo, T. Tsujimura, J. Ninomiya-Tsuji , M. Yamamoto, T. Kawai, O. Takeuchi, S. Akira

author keywords: IBD; regulatory T cells; signal transduction; TCR
MeSH headings : Aging / genetics; Aging / immunology; Aging / pathology; Animals; B-Lymphocytes / immunology; B-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; Colitis / genetics; Colitis / immunology; Colitis / pathology; Colitis / prevention & control; Humans; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / immunology; MAP Kinase Signaling System / genetics; MAP Kinase Signaling System / immunology; Mice; Mice, Knockout; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / pathology; Thymus Gland / immunology; Thymus Gland / pathology
topics (OpenAlex): Immune Cell Function and Interaction; Immune Response and Inflammation
TL;DR: The results show that TAK1, by controlling the generation of central Treg cells, is important for preventing spontaneously developing colitis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2006 journal article

Tab1

AfCS-Nature Molecule Pages, 3.

By: J. Ninomiya-Tsuji*  & K. Matsumoto

topics (OpenAlex): Cancer-related gene regulation; Signaling Pathways in Disease; Histone Deacetylase Inhibitors Research
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2006 journal article

Tak1

AfCS-Nature Molecule Pages, 1.

By: J. Ninomiya-Tsuji*  & K. Matsumoto

topics (OpenAlex): Ubiquitin and proteasome pathways; Hippo pathway signaling and YAP/TAZ; Histone Deacetylase Inhibitors Research
Sources: Crossref, NC State University Libraries
Added: August 28, 2020

2005 article

AMP-Activated Protein Kinase Activates p38 Mitogen-Activated Protein Kinase by Increasing Recruitment of p38 MAPK to TAB1 in the Ischemic Heart

Li, J., Miller, E. J., Ninomiya-Tsuji, J., Russell, R. R., & Young, L. H. (2005, September 23). Circulation Research, Vol. 97, pp. 872–879.

By: J. Li  n, E. Miller  n, J. Ninomiya-Tsuji n , R. Russell n & L. Young  n

Contributors: J. Li  n, E. Miller  n, J. Ninomiya-Tsuji n , R. Russell III n & L. Young  n

author keywords: ischemia; AMP-activated protein kinase; p38 MAPK mitogen-activated protein kinase; transforming growth factor-beta-activated protein kinase 1-binding protein 1; glucose transport
MeSH headings : AMP-Activated Protein Kinases; Aminoimidazole Carboxamide / analogs & derivatives; Aminoimidazole Carboxamide / pharmacology; Animals; Anisomycin / pharmacology; Cell Hypoxia; Enzyme Activation; Glucose / metabolism; Glucose Transporter Type 4 / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; MAP Kinase Kinase 3 / physiology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multienzyme Complexes / physiology; Myocardial Ischemia / enzymology; Protein Serine-Threonine Kinases / physiology; Protein Transport; Rats; Rats, Sprague-Dawley; Ribonucleotides / pharmacology; p38 Mitogen-Activated Protein Kinases / metabolism
topics (OpenAlex): Metabolism, Diabetes, and Cancer; Protein Kinase Regulation and GTPase Signaling; Calcium signaling and nucleotide metabolism
TL;DR: AMP-activated protein kinase has an important role in promoting p38 MAPK activation in the ischemic heart by inducing p38MAPK autophosphorylation through interaction with the scaffold protein TAB1. (via Semantic Scholar)
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Added: August 6, 2018

2005 article

Essential function for the kinase TAK1 in innate and adaptive immune responses

Sato, S., Sanjo, H., Takeda, K., Ninomiya-Tsuji, J., Yamamoto, M., Kawai, T., … Akira, S. (2005, September 25). Nature Immunology, Vol. 6, pp. 1087–1095.

By: S. Sato *, H. Sanjo *, K. Takeda *, J. Ninomiya-Tsuji n , M. Yamamoto *, T. Kawai *, K. Matsumoto *, O. Takeuchi *, S. Akira *

Contributors: S. Sato *, H. Sanjo *, K. Takeda *, J. Ninomiya-Tsuji n , M. Yamamoto *, T. Kawai *, K. Matsumoto *, O. Takeuchi *, S. Akira *

MeSH headings : Animals; B-Lymphocytes / drug effects; B-Lymphocytes / enzymology; B-Lymphocytes / immunology; CD40 Antigens / pharmacology; Embryo, Mammalian / cytology; Fibroblasts / drug effects; Fibroblasts / enzymology; Gene Deletion; Immunity, Innate; Interleukin-17 / pharmacology; Lymphopoiesis; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / physiology; Membrane Glycoproteins / immunology; Mice; Mice, Mutant Strains; NF-kappa B / pharmacology; Receptors, Antigen, B-Cell / agonists; Receptors, Antigen, B-Cell / immunology; Receptors, Cell Surface / immunology; Toll-Like Receptors; Tumor Necrosis Factor-alpha / pharmacology
topics (OpenAlex): Immune Response and Inflammation; interferon and immune responses
TL;DR: It is shown that TAK1 is key in the cellular response to a variety of stimuli and was indispensable for cellular responses to Toll-like receptor ligands, CD40 and B cell receptor crosslinking. (via Semantic Scholar)
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Added: August 6, 2018

2005 article

TAK1‐binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL‐1 signaling pathway

Kishida, S., Sanjo, H., Akira, S., Matsumoto, K., & Ninomiya‐Tsuji, J. (2005, March 31). Genes to Cells, Vol. 10, pp. 447–454.

By: S. Kishida n, H. Sanjo *, S. Akira *, K. Matsumoto * & J. Ninomiya‐Tsuji n 

Contributors: S. Kishida n, H. Sanjo *, S. Akira *, K. Matsumoto * & J. Ninomiya-Tsuji n 

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; I-kappa B Kinase; Interleukin-1 / metabolism; Mice; Mutation; NF-kappa B / metabolism; Protein Serine-Threonine Kinases / metabolism; Protein Structure, Tertiary; Signal Transduction / physiology; TNF Receptor-Associated Factor 6 / metabolism; Ubiquitin / metabolism
topics (OpenAlex): interferon and immune responses; Immune Response and Inflammation
TL;DR: TAK1‐binding protein 2 (TAB2) functions to facilitate TRAF6 ubiquitination and thereby mediates IL‐1‐induced cellular events, and a conserved ubiquitin binding domain in TAB2, the CUE domain, is important for this function. (via Semantic Scholar)
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Added: August 6, 2018

2005 article

Transforming Growth Factor β-Activated Kinase 1 Is a Key Mediator of Ovine Follicle-Stimulating Hormone β-Subunit Expression

Safwat, N., Ninomiya-Tsuji, J., Gore, A. J., & Miller, W. L. (2005, August 5). Endocrinology, Vol. 146, pp. 4814–4824.

By: N. Safwat n, J. Ninomiya-Tsuji n , A. Gore n & W. Miller n

Contributors: N. Safwat n, J. Ninomiya-Tsuji n , A. Gore n & W. Miller n

MeSH headings : Activins / pharmacology; Animals; Cell Line; Enzyme Activation / physiology; Follicle Stimulating Hormone, beta Subunit / antagonists & inhibitors; Follicle Stimulating Hormone, beta Subunit / biosynthesis; Follicle Stimulating Hormone, beta Subunit / genetics; Follicle Stimulating Hormone, beta Subunit / metabolism; Humans; Inhibin-beta Subunits / pharmacology; Kinetics; Lactones / pharmacology; Luciferases / genetics; MAP Kinase Kinase Kinases / metabolism; Phosphorylation; Recombinant Fusion Proteins / biosynthesis; Recombinant Proteins / pharmacology; Resorcinols / pharmacology; Sheep; Transfection; p38 Mitogen-Activated Protein Kinases / metabolism
topics (OpenAlex): Kruppel-like factors research; Reproductive Biology and Fertility
TL;DR: This study used 4.7 kb of the ovine FSHβ-promoter linked to luciferase (oFSHβLuc) plus a well-characterized activin-responsive construct, p3TPLuc, to investigate the hypothesis that Smad3, TGFβ-activated kinase 1 (TAK1), or both cause activationin-mediated induction of FSH. (via Semantic Scholar)
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Added: August 6, 2018

2004 article

Activation Mechanism of c-Jun Amino-terminal Kinase in the Course of Neural Differentiation of P19 Embryonic Carcinoma Cells

Akiyama, S., Yonezawa, T., Kudo, T.-aki, Li, M. G., Wang, H., Ito, M., … Kobayashi, T. (2004, June 25). Journal of Biological Chemistry, Vol. 279, pp. 36616–36620.

By: S. Akiyama *, T. Yonezawa *, T. Kudo *, M. Li*, H. Wang*, M. Ito *, K. Yoshioka *, J. Ninomiya-Tsuji n  ...

Contributors: S. Akiyama *, T. Yonezawa *, T. Kudo *, M. Li*, H. Wang*, M. Ito *, K. Yoshioka *, J. Ninomiya-Tsuji n  ...

MeSH headings : Animals; Blotting, Northern; Carcinoma, Embryonal / metabolism; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Nucleus / metabolism; Enzyme Activation; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Developmental; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 4; MAP Kinase Kinase Kinases / metabolism; Mice; Microscopy, Confocal; Mitogen-Activated Protein Kinases / metabolism; Neurons / metabolism; Phosphoprotein Phosphatases / metabolism; Precipitin Tests; Protein Phosphatase 2C; Signal Transduction; Transfection; Tretinoin / metabolism; Tubulin / metabolism
topics (OpenAlex): Melanoma and MAPK Pathways; Retinoids in leukemia and cellular processes
TL;DR: It is demonstrated that activities of MAPK kinase 4 and TAK1, one of the upstream kinases of MKK4, were enhanced in the neurally differentiating cells and suggest that two distinct TAK 1-MKK4-JNK signaling pathways are independently activated at the different intracellular locations and may participate in the regulation of the neural differentiation of P19 cells. (via Semantic Scholar)
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Added: August 6, 2018

2004 journal article

Involvement of ASK1 in Ca 2+ ‐induced p38 MAP kinase activation

EMBO Reports, 5(2), 161–166.

By: K. Takeda *, A. Matsuzawa *, H. Nishitoh *, K. Tobiume *, S. Kishida*, J. Ninomiya‐Tsuji* , K. Matsumoto *, H. Ichijo *

Contributors: K. Takeda *, A. Matsuzawa *, H. Nishitoh *, K. Tobiume *, S. Kishida*, J. Ninomiya-Tsuji* , K. Matsumoto *, H. Ichijo *

MeSH headings : Animals; Calcium / metabolism; Calcium / pharmacology; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Cells, Cultured; Fibroblasts / drug effects; Fibroblasts / metabolism; Glutathione Transferase / analysis; MAP Kinase Kinase Kinase 5 / metabolism; MAP Kinase Kinase Kinase 5 / physiology; MAP Kinase Signaling System / physiology; Marine Toxins / pharmacology; Mice; Mice, Inbred C57BL; Oxocins / pharmacology; Phosphorylation; Potassium Channels, Calcium-Activated / metabolism; RNA, Small Interfering / pharmacology; Synaptosomes / drug effects; Synaptosomes / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
topics (OpenAlex): Redox biology and oxidative stress; Genomics, phytochemicals, and oxidative stress; RNA regulation and disease
TL;DR: It is shown that Ca2+ signalling regulates the ASK1–p38 MAP kinase cascade, which is a critical intermediate of Ca2- signalling between CaMKII and p38 MAP Kinase. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 5, 2021

2004 article

Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK

Kanei-Ishii, C., Ninomiya-Tsuji, J., Tanikawa, J., Nomura, T., Ishitani, T., Kishida, S., … Ishii, S. (2004, April 1). Genes & Development, Vol. 18, pp. 816–829.

By: C. Kanei-Ishii*, J. Ninomiya-Tsuji* , J. Tanikawa *, T. Nomura*, T. Ishitani*, S. Kishida*, K. Kokura *, T. Kurahashi* ...

Contributors: C. Kanei-Ishii*, J. Ninomiya-Tsuji* , J. Tanikawa *, T. Nomura*, T. Ishitani*, S. Kishida*, K. Kokura *, T. Kurahashi* ...

MeSH headings : Animals; Carrier Proteins / metabolism; Chloramphenicol O-Acetyltransferase / metabolism; Down-Regulation; Glutathione Transferase / metabolism; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mitogen-Activated Protein Kinases / metabolism; Mitogens; Nuclear Proteins / metabolism; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases / metabolism; Protein-Tyrosine Kinases / metabolism; Proto-Oncogene Mas; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins c-myb / antagonists & inhibitors; Proto-Oncogene Proteins c-myb / metabolism; RNA, Small Interfering / pharmacology; Saccharomyces cerevisiae; Signal Transduction; Two-Hybrid System Techniques; Ubiquitin; Wnt Proteins; Wnt1 Protein; Zebrafish Proteins
topics (OpenAlex): Cancer-related gene regulation
Source: ORCID
Added: September 1, 2024

2003 article

A Resorcylic Acid Lactone, 5Z-7-Oxozeaenol, Prevents Inflammation by Inhibiting the Catalytic Activity of TAK1 MAPK Kinase Kinase

Ninomiya-Tsuji, J., Kajino, T., Ono, K., Ohtomo, T., Matsumoto, M., Shiina, M., … Matsumoto, K. (2003, May 1). Journal of Biological Chemistry, Vol. 278, pp. 18485–18490.

By: J. Ninomiya-Tsuji n , T. Kajino *, K. Ono, T. Ohtomo, M. Matsumoto, M. Shiina, M. Mihara, M. Tsuchiya, K. Matsumoto *

Contributors: J. Ninomiya-Tsuji n , T. Kajino *, K. Ono, T. Ohtomo, M. Matsumoto, M. Shiina, M. Mihara, M. Tsuchiya, K. Matsumoto *

MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Cell Line; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Activation; Female; Genes, Reporter; Genetic Vectors; Humans; Immunoblotting; Inflammation; Inhibitory Concentration 50; Interleukin-1 / metabolism; Isoenzymes / metabolism; Lactones / chemistry; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases / metabolism; Models, Chemical; Precipitin Tests; Prostaglandin-Endoperoxide Synthases / metabolism; Protein Binding; Signal Transduction; Time Factors; Transfection; Zearalenone / analogs & derivatives; Zearalenone / chemistry; Zearalenone / pharmacology; p38 Mitogen-Activated Protein Kinases
topics (OpenAlex): Bioactive Compounds and Antitumor Agents; Genomics, phytochemicals, and oxidative stress
TL;DR: 5Z-7-oxozeaenol blocks proinflammatory signaling by selectively inhibiting TAK1 MAPKKK, resulting in inhibition of cyclooxgenase-2 production in cell culture and in vivo. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2003 article

A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-β

Ono, K., Ohtomo, T., Ninomiya-Tsuji, J., & Tsuchiya, M. (2003, June 30). Biochemical and Biophysical Research Communications, Vol. 307, pp. 332–337.

By: K. Ono, T. Ohtomo, J. Ninomiya-Tsuji n  & M. Tsuchiya

Contributors: K. Ono, T. Ohtomo, J. Ninomiya-Tsuji n  & M. Tsuchiya

author keywords: transforming growth factor-beta; TGF-beta activated kinase 1; dominant negative inhibitor; fibrotic marker proteins
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Biomarkers; Carrier Proteins / metabolism; Cell Line; Collagen Type I / metabolism; Collagen Type IV / metabolism; Extracellular Matrix / metabolism; Fibronectins / metabolism; Fibrosis / metabolism; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Plasminogen Activator Inhibitor 1 / metabolism; Protein Binding; Signal Transduction / physiology; Transforming Growth Factor beta / metabolism; Two-Hybrid System Techniques
topics (OpenAlex): Cell Adhesion Molecules Research
TL;DR: A minimal portion of TAK1 lacking kinase activity that binds to TAB1 was designed as a Tak1 dominant negative inhibitor (TAK1-DN) that decreased the ECM protein production, indicating that TAK 1-DN retains the ability to intercept the TGF-beta signaling effectively. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2003 article

Regulation of Lymphoid Enhancer Factor 1/T-Cell Factor by Mitogen-Activated Protein Kinase-Related Nemo-Like Kinase-Dependent Phosphorylation in Wnt/β-Catenin Signaling

Ishitani, T., Ninomiya-Tsuji, J., & Matsumoto, K. (2003, January 29). Molecular and Cellular Biology, Vol. 23, pp. 1379–1389.

By: T. Ishitani*, J. Ninomiya-Tsuji*  & K. Matsumoto*

Contributors: T. Ishitani*, J. Ninomiya-Tsuji*  & K. Matsumoto*

MeSH headings : Amino Acid Sequence; Amino Acid Substitution; Cells, Cultured; Cytoskeletal Proteins / genetics; Cytoskeletal Proteins / metabolism; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Down-Regulation; Humans; Intracellular Signaling Peptides and Proteins; Lymphoid Enhancer-Binding Factor 1; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; Mutation; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins / metabolism; Sequence Homology, Amino Acid; Serine / metabolism; Signal Transduction; TCF Transcription Factors; Threonine / metabolism; Trans-Activators / genetics; Trans-Activators / metabolism; Transcription Factor 7-Like 2 Protein; Transcription Factors / genetics; Transcription Factors / metabolism; Two-Hybrid System Techniques; Valine; Wnt Proteins; Zebrafish Proteins; beta Catenin
topics (OpenAlex): Kruppel-like factors research; Cancer-related gene regulation
Source: ORCID
Added: September 1, 2024

2003 article

Regulation of the Interleukin-1-induced Signaling Pathways by a Novel Member of the Protein Phosphatase 2C Family (PP2Cε)

Li, M. G., Katsura, K., Nomiyama, H., Komaki, K.-ichiro, Ninomiya-Tsuji, J., Matsumoto, K., … Tamura, S. (2003, March 28). Journal of Biological Chemistry, Vol. 278, pp. 12013–12021.

By: M. Li*, K. Katsura*, H. Nomiyama *, K. Komaki*, J. Ninomiya-Tsuji n , K. Matsumoto *, T. Kobayashi*, S. Tamura*

Contributors: M. Li*, K. Katsura*, H. Nomiyama *, K. Komaki*, J. Ninomiya-Tsuji n , K. Matsumoto *, T. Kobayashi*, S. Tamura*

MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Escherichia coli; Gene Expression Regulation, Enzymologic; Genes, Reporter; In Vitro Techniques; Interleukin-1 / pharmacology; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 3; MAP Kinase Kinase 4; MAP Kinase Kinase 6; MAP Kinase Kinase Kinases / metabolism; Mice; Mitogen-Activated Protein Kinase Kinases / metabolism; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; Phosphoprotein Phosphatases / genetics; Phosphoprotein Phosphatases / metabolism; Phosphorylation; Point Mutation; Protein Phosphatase 2C; Protein-Tyrosine Kinases / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; Transcription Factor AP-1 / genetics; p38 Mitogen-Activated Protein Kinases
topics (OpenAlex): Protein Tyrosine Phosphatases; Cytokine Signaling Pathways and Interactions
TL;DR: Results suggest that, in the absence of IL-1-induced signal, PP2Cε contributes to keeping the TAK1 signaling pathway in an inactive state by associating with and dephosphorylating TAK 1. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2003 article

Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling

Ishitani, T., Takaesu, G., Ninomiya-Tsuji, J., Shibuya, H., Gaynor, R. B., & Matsumoto, K. (2003, November 21). The EMBO Journal, Vol. 22, pp. 6277–6288.

By: T. Ishitani*, G. Takaesu *, J. Ninomiya-Tsuji* , H. Shibuya *, R. Gaynor* & K. Matsumoto *

Contributors: T. Ishitani*, G. Takaesu *, J. Ninomiya-Tsuji* , H. Shibuya *, R. Gaynor* & K. Matsumoto *

MeSH headings : Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins / physiology; Cloning, Molecular; DNA Primers; Drosophila / genetics; Humans; Inflammation / genetics; Inflammation / prevention & control; Interleukin-1 / physiology; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; NF-kappa B / metabolism; Proteins / genetics; Recombinant Proteins / metabolism; Sequence Alignment; Sequence Homology, Amino Acid; Signal Transduction; TNF Receptor-Associated Factor 2; TNF Receptor-Associated Factor 6; Tumor Necrosis Factor-alpha / physiology
topics (OpenAlex): Immune Response and Inflammation; interferon and immune responses
Source: ORCID
Added: September 1, 2024

2003 article

TAB2 Is Essential for Prevention of Apoptosis in Fetal Liver but Not for Interleukin-1 Signaling

Sanjo, H., Takeda, K., Tsujimura, T., Ninomiya-Tsuji, J., Matsumoto, K., & Akira, S. (2003, January 29). Molecular and Cellular Biology, Vol. 23, pp. 1231–1238.

By: H. Sanjo *, K. Takeda *, T. Tsujimura *, J. Ninomiya-Tsuji* , K. Matsumoto * & S. Akira *

Contributors: H. Sanjo *, K. Takeda *, T. Tsujimura *, J. Ninomiya-Tsuji* , K. Matsumoto * & S. Akira *

MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Apoptosis / genetics; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cells, Cultured; Fetal Death / genetics; Fibroblasts / drug effects; Fibroblasts / physiology; Genetic Engineering / methods; Inflammation / metabolism; Interleukin-1 / metabolism; Interleukin-1 / pharmacology; Intracellular Signaling Peptides and Proteins; Liver / embryology; Liver / metabolism; Liver / pathology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Mutant Strains; Mitogen-Activated Protein Kinases / drug effects; Mitogen-Activated Protein Kinases / metabolism; NF-kappa B / drug effects; NF-kappa B / metabolism; Phosphorylation; Signal Transduction; Tumor Necrosis Factor-alpha / metabolism; Tumor Necrosis Factor-alpha / pharmacology
topics (OpenAlex): Peroxisome Proliferator-Activated Receptors; Immune Response and Inflammation
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 1, 2024

2003 article

TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway

Takaesu, G., Surabhi, R. M., Park, K.-J., Ninomiya-Tsuji, J., Matsumoto, K., & Gaynor, R. B. (2003, January 30). Journal of Molecular Biology, Vol. 326, pp. 105–115.

By: G. Takaesu *, R. Surabhi*, K. Park*, J. Ninomiya-Tsuji n , K. Matsumoto * & R. Gaynor*

Contributors: G. Takaesu *, R. Surabhi*, K. Park*, J. Ninomiya-Tsuji n , K. Matsumoto * & R. Gaynor*

author keywords: NF-kappa B; I kappa B kinase; TAK1; signal transduction; RNA interference
MeSH headings : Enzyme Activation / drug effects; Gene Expression; HeLa Cells; Humans; I-kappa B Kinase; Interleukin-1 / pharmacology; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; NF-kappa B / metabolism; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Proteins / genetics; Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; Signal Transduction / drug effects; TNF Receptor-Associated Factor 2; Transfection; Tumor Necrosis Factor-alpha / pharmacology
topics (OpenAlex): Immune Response and Inflammation; interferon and immune responses
TL;DR: Small interfering RNAs directed against IKKα, IKKβ and the upstream regulatory kinase TAK1 were utilized in order to better define their roles in cytokine-induced activation of the NF-κB pathway. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2002 article

Interleukin-1 (IL-1) Receptor-Associated Kinase-Dependent IL-1-Induced Signaling Complexes Phosphorylate TAK1 and TAB2 at the Plasma Membrane and Activate TAK1 in the Cytosol

Jiang, Z., Ninomiya-Tsuji, J., Qian, Y., Matsumoto, K., & Li, X. (2002, September 19). Molecular and Cellular Biology, Vol. 22, pp. 7158–7167.

By: Z. Jiang *, J. Ninomiya-Tsuji* , Y. Qian *, K. Matsumoto * & X. Li *

Contributors: Z. Jiang *, J. Ninomiya-Tsuji* , Y. Qian *, K. Matsumoto * & X. Li *

MeSH headings : Adaptor Proteins, Signal Transducing; Carrier Proteins / metabolism; Cell Line; Cell Membrane / metabolism; Cytosol / metabolism; Enzyme Activation; Humans; Interleukin-1 / metabolism; Interleukin-1 Receptor-Associated Kinases; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases / metabolism; Mitogen-Activated Protein Kinases / metabolism; NF-kappa B / metabolism; Phosphorylation; Protein Kinases / genetics; Protein Kinases / metabolism; Proteins / metabolism; Receptors, Interleukin-1 / metabolism; Signal Transduction; TNF Receptor-Associated Factor 6
topics (OpenAlex): Immune Response and Inflammation; interferon and immune responses
Source: ORCID
Added: September 1, 2024

2002 article

Receptor Activator of NF-κB Ligand (RANKL) Activates TAK1 Mitogen-Activated Protein Kinase Kinase Kinase through a Signaling Complex Containing RANK, TAB2, and TRAF6

Mizukami, J., Takaesu, G., Akatsuka, H., Sakurai, H., Ninomiya-Tsuji, J., Matsumoto, K., & Sakurai, N. (2002, February 1). Molecular and Cellular Biology, Vol. 22, pp. 992–1000.

By: J. Mizukami, G. Takaesu *, H. Akatsuka*, H. Sakurai *, J. Ninomiya-Tsuji* , K. Matsumoto *, N. Sakurai *

Contributors: J. Mizukami, G. Takaesu *, H. Akatsuka*, H. Sakurai *, J. Ninomiya-Tsuji* , K. Matsumoto *, N. Sakurai *

MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins / metabolism; Cell Line; Enzyme Activation; Genes, Reporter; Glycoproteins / metabolism; Humans; Ligands; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System / physiology; Macrophages / metabolism; Membrane Glycoproteins / metabolism; Mice; NF-kappa B / metabolism; Osteoprotegerin; Precipitin Tests; Proteins / metabolism; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear / metabolism; Receptors, Tumor Necrosis Factor / metabolism; TNF Receptor-Associated Factor 6; Transfection
topics (OpenAlex): Bone Metabolism and Diseases; Cytokine Signaling Pathways and Interactions
Source: ORCID
Added: September 1, 2024

2002 article

SEK‐1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans

Tanaka‐Hino, M., Sagasti, A., Hisamoto, N., Kawasaki, M., Nakano, S., Ninomiya‐Tsuji, J., … Matsumoto, K. (2002, January 1). EMBO Reports, Vol. 3, pp. 56–62.

By: M. Tanaka‐Hino*, A. Sagasti *, N. Hisamoto *, M. Kawasaki *, S. Nakano *, J. Ninomiya‐Tsuji* , C. Bargmann *, K. Matsumoto *

Contributors: M. Tanaka-Hino*, A. Sagasti *, N. Hisamoto *, M. Kawasaki *, S. Nakano *, J. Ninomiya-Tsuji* , C. Bargmann *, K. Matsumoto *

MeSH headings : Amino Acid Sequence; Animals; Body Patterning; Caenorhabditis elegans / embryology; Caenorhabditis elegans / enzymology; Caenorhabditis elegans / physiology; Caenorhabditis elegans Proteins / metabolism; Calcium Signaling / physiology; Cell Line; Gene Deletion; Humans; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases / metabolism; Mitogen-Activated Protein Kinase Kinases / genetics; Mitogen-Activated Protein Kinase Kinases / physiology; Molecular Sequence Data; Mutation; Neurons / cytology; Sequence Homology, Amino Acid
topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms; Neurobiology and Insect Physiology Research; Circadian rhythm and melatonin
Source: ORCID
Added: September 1, 2024

2002 article

Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis

Komatsu, Y., Shibuya, H., Takeda, N., Ninomiya-Tsuji, J., Yasui, T., Miyado, K., … Yamada. (2002, December 1). Mechanisms of Development, Vol. 119, pp. 239–249.

By: Y. Komatsu *, H. Shibuya *, N. Takeda *, J. Ninomiya-Tsuji n , T. Yasui*, K. Miyado *, T. Sekimoto*, N. Ueno *, K. Matsumoto *, . Yamada *

Contributors: Y. Komatsu *, H. Shibuya *, N. Takeda *, J. Ninomiya-Tsuji n , T. Yasui*, K. Miyado *, T. Sekimoto*, N. Ueno *, K. Matsumoto *, G. Yamada *

author keywords: bone morphogenetic protein; mitogen-activated protein kinase; mouse; signal transduction; TGF-beta activated kinase-1 binding protein-1; TGF-beta activated kinase-1; transforming growth factor-beta
MeSH headings : Adaptor Proteins, Signal Transducing; Alleles; Amino Acid Sequence; Animals; Blotting, Western; Cell Differentiation; Cell Division; Cloning, Molecular; Genotype; HIV Envelope Protein gp120 / genetics; HIV Envelope Protein gp120 / physiology; Heart / embryology; Homozygote; Humans; Immunoblotting; In Situ Hybridization; Luciferases / metabolism; Lung / embryology; MAP Kinase Kinase Kinases / metabolism; Mice; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oligonucleotides, Antisense / pharmacology; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / physiology; Recombination, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Tissue Distribution; Transfection; Transforming Growth Factor beta / metabolism
topics (OpenAlex): Cancer-related gene regulation
TL;DR: A possibility that TAB1 plays an important role in mammalian embryogenesis and is required for TAK1 activation in TGF-beta signaling is indicated. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2002 article

The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca2+ Pathway To Antagonize Wnt/β-Catenin Signaling

Ishitani, T., Kishida, S., Hyodo-Miura, J., Ueno, N., Yasuda, J., Waterman, M., … Matsumoto, K. (2002, December 13). Molecular and Cellular Biology, Vol. 23, pp. 131–139.

By: T. Ishitani*, S. Kishida*, J. Hyodo-Miura*, N. Ueno *, J. Yasuda *, M. Waterman *, H. Shibuya *, R. Moon *, J. Ninomiya-Tsuji* , K. Matsumoto*

Contributors: T. Ishitani*, S. Kishida*, J. Hyodo-Miura*, N. Ueno *, J. Yasuda *, M. Waterman *, H. Shibuya *, R. Moon *, J. Ninomiya-Tsuji* , K. Matsumoto*

MeSH headings : Adrenergic beta-Agonists / pharmacology; Animals; Calcium / metabolism; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases / genetics; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Cells, Cultured; Cytoskeletal Proteins / genetics; Cytoskeletal Proteins / metabolism; Frizzled Receptors; Humans; Intracellular Signaling Peptides and Proteins; Isoproterenol / pharmacology; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins / metabolism; Rats; Receptors, Adrenergic, beta-2 / drug effects; Receptors, Adrenergic, beta-2 / genetics; Receptors, Adrenergic, beta-2 / metabolism; Receptors, G-Protein-Coupled; Receptors, Neurotransmitter / genetics; Receptors, Neurotransmitter / metabolism; Recombinant Proteins / drug effects; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Signal Transduction; Trans-Activators / genetics; Trans-Activators / metabolism; Wnt Proteins; Wnt-5a Protein; beta Catenin
topics (OpenAlex): Cancer-related gene regulation; Genetics and Neurodevelopmental Disorders
Source: ORCID
Added: September 1, 2024

2001 article

A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK

Inoue, H., Tateno, M., Fujimura-Kamada, K., Takaesu, G., Adachi-Yamada, T., Ninomiya-Tsuji, J., … Matsumoto, K. (2001, October 1). The EMBO Journal, Vol. 20, pp. 5421–5430.

By: H. Inoue *, M. Tateno, K. Fujimura-Kamada, G. Takaesu, T. Adachi-Yamada, J. Ninomiya-Tsuji , K. Irie, Y. Nishida, K. Matsumoto

Contributors: H. Inoue *, M. Tateno, K. Fujimura-Kamada, G. Takaesu, T. Adachi-Yamada, J. Ninomiya-Tsuji , K. Irie, Y. Nishida, K. Matsumoto

MeSH headings : Adaptation, Biological; Amino Acid Sequence; Animals; Drosophila / enzymology; Environment; Enzyme Activation; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; Protein Serine-Threonine Kinases / metabolism; Sequence Homology, Amino Acid; p38 Mitogen-Activated Protein Kinases
topics (OpenAlex): Invertebrate Immune Response Mechanisms; Melanoma and MAPK Pathways; Microbial Metabolism and Applications
Source: ORCID
Added: September 1, 2024

2001 article

An Evolutionarily Conserved Motif in the TAB1 C-terminal Region Is Necessary for Interaction with and Activation of TAK1 MAPKKK

Ono, K., Ohtomo, T., Sato, S., Sugamata, Y., Suzuki, M., Hisamoto, N., … Matsumoto, K. (2001, June 1). Journal of Biological Chemistry, Vol. 276, pp. 24396–24400.

By: K. Ono, T. Ohtomo, S. Sato, Y. Sugamata, M. Suzuki*, N. Hisamoto *, J. Ninomiya-Tsuji* , M. Tsuchiya, K. Matsumoto *

Contributors: K. Ono, T. Ohtomo, S. Sato, Y. Sugamata, M. Suzuki*, N. Hisamoto *, J. Ninomiya-Tsuji* , M. Tsuchiya, K. Matsumoto *

MeSH headings : Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Caenorhabditis elegans / genetics; Cell Line; Conserved Sequence; Enzyme Activation; Evolution, Molecular; HIV Envelope Protein gp120 / chemistry; HIV Envelope Protein gp120 / genetics; HIV Envelope Protein gp120 / metabolism; MAP Kinase Kinase Kinases / metabolism; Molecular Sequence Data; Mutation; Phenylalanine / genetics; Protein Structure, Tertiary; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Sequence Homology, Amino Acid; Xenopus / genetics
topics (OpenAlex): Melanoma and MAPK Pathways; Cytokine Signaling Pathways and Interactions
Source: ORCID
Added: September 1, 2024

2001 article

IRAK-mediated Translocation of TRAF6 and TAB2 in the Interleukin-1-induced Activation of NFκB

Qian, Y., Commane, M., Ninomiya-Tsuji, J., Matsumoto, K., & Li, X. (2001, November 1). Journal of Biological Chemistry, Vol. 276, pp. 41661–41667.

By: Y. Qian *, M. Commane*, J. Ninomiya-Tsuji* , K. Matsumoto * & X. Li *

Contributors: Y. Qian *, M. Commane*, J. Ninomiya-Tsuji* , K. Matsumoto * & X. Li *

MeSH headings : Adaptor Proteins, Signal Transducing; Biological Transport; Carrier Proteins / metabolism; Cell Membrane / metabolism; Cytosol / metabolism; HIV Envelope Protein gp120 / metabolism; Interleukin-1 / pharmacology; Interleukin-1 Receptor-Associated Kinases; NF-kappa B / metabolism; Phosphorylation; Protein Kinases / chemistry; Protein Kinases / physiology; Proteins / metabolism; Recombinant Fusion Proteins / metabolism; TNF Receptor-Associated Factor 6; Transforming Growth Factor beta / pharmacology
topics (OpenAlex): Immune Response and Inflammation; Cytokine Signaling Pathways and Interactions
Source: ORCID
Added: September 1, 2024

2001 article

Interleukin-1 (IL-1) Receptor-Associated Kinase Leads to Activation of TAK1 by Inducing TAB2 Translocation in the IL-1 Signaling Pathway

Takaesu, G., Ninomiya-Tsuji, J., Kishida, S., Li, X., Stark, G. R., & Matsumoto, K. (2001, April 1). Molecular and Cellular Biology, Vol. 21, pp. 2475–2484.

By: G. Takaesu *, J. Ninomiya-Tsuji* , S. Kishida*, X. Li, G. Stark * & K. Matsumoto *

Contributors: G. Takaesu *, J. Ninomiya-Tsuji* , S. Kishida*, X. Li, G. Stark * & K. Matsumoto *

MeSH headings : Adaptor Proteins, Signal Transducing; Carrier Proteins / physiology; Cell Line; Enzyme Activation; Humans; Interleukin-1 / physiology; MAP Kinase Kinase Kinases / physiology; MAP Kinase Signaling System; Receptors, Interleukin-1 / physiology; Signal Transduction
topics (OpenAlex): Immune Response and Inflammation; interferon and immune responses
Source: ORCID
Added: September 1, 2024

2001 article

Regulation of the TAK1 Signaling Pathway by Protein Phosphatase 2C

Hanada, M., Ninomiya-Tsuji, J., Komaki, K.-ichiro, Ohnishi, M., Katsura, K., Kanamaru, R., … Tamura, S. (2001, February 1). Journal of Biological Chemistry, Vol. 276, pp. 5753–5759.

By: M. Hanada*, J. Ninomiya-Tsuji* , K. Komaki*, M. Ohnishi, K. Katsura, R. Kanamaru*, K. Matsumoto *, S. Tamura

Contributors: M. Hanada*, J. Ninomiya-Tsuji* , K. Komaki*, M. Ohnishi, K. Katsura, R. Kanamaru*, K. Matsumoto *, S. Tamura

MeSH headings : Adaptation, Biological / physiology; Animals; Binding Sites; COS Cells; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Cells, Cultured; Interleukin-1 / pharmacology; Isoenzymes / metabolism; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase 6; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases / metabolism; Phosphoprotein Phosphatases / metabolism; Protein Binding; Protein Phosphatase 2; Protein Phosphatase 2C; Saccharomyces cerevisiae Proteins; Transforming Growth Factor beta / pharmacology
topics (OpenAlex): Signaling Pathways in Disease; Melanoma and MAPK Pathways
Source: ORCID
Added: September 1, 2024

2001 article

The MAPK Kinase Kinase TAK1 Plays a Central Role in Coupling the Interleukin-1 Receptor to Both Transcriptional and RNA-targeted Mechanisms of Gene Regulation

Holtmann, H., Enninga, J., Kälble, S., Thiefes, A., Dörrie, A., Broemer, M., … Kracht, M. (2001, February 1). Journal of Biological Chemistry, Vol. 276, pp. 3508–3516.

By: H. Holtmann*, J. Enninga *, S. Kälble*, A. Thiefes*, A. Dörrie*, M. Broemer *, R. Winzen*, A. Wilhelm* ...

Contributors: H. Holtmann*, J. Enninga *, S. Kälble*, A. Thiefes*, A. Dörrie*, M. Broemer *, R. Winzen*, A. Wilhelm* ...

MeSH headings : Adaptor Proteins, Signal Transducing; Carrier Proteins / genetics; Carrier Proteins / physiology; Enzyme Activation; Gene Expression Regulation / physiology; Globins / genetics; Globins / metabolism; HeLa Cells; Humans; Interleukin-8 / biosynthesis; Interleukin-8 / genetics; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / physiology; Mitogen-Activated Protein Kinase Kinases / metabolism; Mitogen-Activated Protein Kinases / metabolism; Mutation; NF-kappa B / metabolism; Promoter Regions, Genetic / physiology; RNA Stability; RNA, Messenger / metabolism; Receptors, Interleukin-1 / physiology; Receptors, Interleukin-8A / genetics; Receptors, Interleukin-8A / metabolism; Transcription, Genetic / physiology; Transcriptional Activation; p38 Mitogen-Activated Protein Kinases
topics (OpenAlex): Immune Response and Inflammation; Cytokine Signaling Pathways and Interactions
Source: ORCID
Added: September 1, 2024

2000 journal article

ASK1 inhibits interleukin-1-induced NF-κB activity through disruption of TRAF6-TAK1 interaction

Journal of Biological Chemistry, 275(42), 32747–32752. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034693222&partnerID=MN8TOARS

By: Y. Mochida, K. Takeda, M. Saitoh, H. Nishitoh, T. Amagasa, J. Ninomiya-Tsuji , K. Matsumoto, H. Ichijo

Contributors: Y. Mochida, K. Takeda, M. Saitoh, H. Nishitoh, T. Amagasa, J. Ninomiya-Tsuji , K. Matsumoto, H. Ichijo

www.scopus.com
Source: ORCID
Added: September 1, 2024

2000 article

Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up‐regulated during postnatal mouse cerebral development

Dan, I., Watanabe, N. M., Kobayashi, T., Yamashita-Suzuki, K., Fukagaya, Y., Kajikawa, E., … Kusumi, A. (2000, March 3). FEBS Letters, Vol. 469, pp. 19–23.

By: I. Dan, N. Watanabe*, T. Kobayashi, K. Yamashita-Suzuki, Y. Fukagaya, E. Kajikawa, W. Kimura*, T. Nakashima * ...

Contributors: I. Dan, N. Watanabe*, T. Kobayashi, K. Yamashita-Suzuki, Y. Fukagaya, E. Kajikawa, W. Kimura*, T. Nakashima * ...

MeSH headings : Amino Acid Sequence; Animals; Brain / enzymology; Brain / growth & development; Cell Line; Cloning, Molecular; Enzyme Activation; Gene Expression Regulation, Developmental; Germinal Center Kinases; Mice; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; Nerve Tissue Proteins / chemistry; Nerve Tissue Proteins / genetics; Phylogeny; Protein Serine-Threonine Kinases / chemistry; Protein Serine-Threonine Kinases / genetics; RNA, Messenger / metabolism; Signal Transduction; Transfection; Up-Regulation
topics (OpenAlex): Melanoma and MAPK Pathways; Microtubule and mitosis dynamics; Protein Kinase Regulation and GTPase Signaling
Source: ORCID
Added: September 1, 2024

2000 journal article

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

Molecular Cell, 5(4), 649–658. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033634977&partnerID=MN8TOARS

By: G. Takaesu, S. Kishida, A. Hiyama, K. Yamaguchi, H. Shibuya, K. Irie, J. Ninomiya-Tsuji , K. Matsumoto

Contributors: G. Takaesu, S. Kishida, A. Hiyama, K. Yamaguchi, H. Shibuya, K. Irie, J. Ninomiya-Tsuji , K. Matsumoto

www.scopus.com
Source: ORCID
Added: September 1, 2024

2000 article

TAK1 Mitogen-activated Protein Kinase Kinase Kinase Is Activated by Autophosphorylation within Its Activation Loop

Kishimoto, K., Matsumoto, K., & Ninomiya-Tsuji, J. (2000, March 1). Journal of Biological Chemistry, Vol. 275, pp. 7359–7364.

By: K. Kishimoto*, K. Matsumoto * & J. Ninomiya-Tsuji* 

Contributors: K. Kishimoto*, K. Matsumoto * & J. Ninomiya-Tsuji* 

MeSH headings : Amino Acid Sequence; Cells, Cultured; Enzyme Activation; Humans; Interleukin-1 / pharmacology; MAP Kinase Kinase Kinases / chemistry; MAP Kinase Kinase Kinases / metabolism; Molecular Sequence Data; NF-kappa B / physiology; Phosphorylation; Structure-Activity Relationship
topics (OpenAlex): Melanoma and MAPK Pathways; Cell Adhesion Molecules Research; Protein Kinase Regulation and GTPase Signaling
Source: ORCID
Added: September 1, 2024

1999 article

A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons

Kawasaki, M., Hisamoto, N., Iino, Y., Yamamoto, M., Ninomiya‐Tsuji, J., & Matsumoto, K. (1999, July 1). The EMBO Journal, Vol. 18, pp. 3604–3615.

By: M. Kawasaki *, N. Hisamoto *, Y. Iino *, M. Yamamoto *, J. Ninomiya‐Tsuji*  & K. Matsumoto *

Contributors: M. Kawasaki *, N. Hisamoto *, Y. Lino *, M. Yamamoto *, J. Ninomiya-Tsuji*  & K. Matsumoto *

MeSH headings : Amino Acid Sequence; Animals; Axons / enzymology; Caenorhabditis elegans / cytology; Caenorhabditis elegans / enzymology; Caenorhabditis elegans / genetics; Caenorhabditis elegans / physiology; Caenorhabditis elegans Proteins; Calcium-Calmodulin-Dependent Protein Kinases / chemistry; Calcium-Calmodulin-Dependent Protein Kinases / genetics; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Cell Line; Enzyme Activation; Gene Deletion; Gene Expression; Genes, Fungal; Genes, Helminth; Genetic Complementation Test; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Motor Neurons / cytology; Motor Neurons / enzymology; Motor Neurons / physiology; Movement; Phylogeny; Protein Kinases / chemistry; Protein Kinases / genetics; Protein Kinases / metabolism; Signal Transduction; Substrate Specificity; gamma-Aminobutyric Acid / physiology
topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms; Circadian rhythm and melatonin; CRISPR and Genetic Engineering
Source: ORCID
Added: September 1, 2024

1999 article

Involvement of the p38 Mitogen-activated Protein Kinase Pathway in Transforming Growth Factor-β-induced Gene Expression

Hanafusa, H., Ninomiya-Tsuji, J., Masuyama, N., Nishita, M., Fujisawa, J.-ichi, Shibuya, H., … Nishida, E. (1999, September 1). Journal of Biological Chemistry, Vol. 274, pp. 27161–27167.

By: H. Hanafusa *, J. Ninomiya-Tsuji* , N. Masuyama*, M. Nishita *, J. Fujisawa *, H. Shibuya *, K. Matsumoto *, E. Nishida *

Contributors: H. Hanafusa *, J. Ninomiya-Tsuji* , N. Masuyama*, M. Nishita *, J. Fujisawa *, H. Shibuya *, K. Matsumoto *, E. Nishida *

MeSH headings : Activating Transcription Factor 2; Animals; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Calcium-Calmodulin-Dependent Protein Kinases / physiology; Cells, Cultured; Cyclic AMP Response Element-Binding Protein / metabolism; DNA-Binding Proteins / metabolism; Gene Expression Regulation; Genes, Tumor Suppressor; Leucine Zippers; MAP Kinase Kinase 6; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Protein Kinases / metabolism; Signal Transduction; Trans-Activators / metabolism; Transcription Factors / metabolism; Transforming Growth Factor beta / physiology; p38 Mitogen-Activated Protein Kinases
topics (OpenAlex): Protein Kinase Regulation and GTPase Signaling; Bone Metabolism and Diseases
Source: ORCID
Added: September 1, 2024

1999 article

MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans

Meneghini, M. D., Ishitani, T., Carter, J. C., Hisamoto, N., Ninomiya-Tsuji, J., Thorpe, C. J., … Bowerman, B. (1999, June 1). Nature, Vol. 399, pp. 793–797.

By: M. Meneghini *, T. Ishitani*, J. Carter*, N. Hisamoto *, J. Ninomiya-Tsuji* , C. Thorpe *, D. Hamill *, K. Matsumoto *, B. Bowerman *

Contributors: M. Meneghini *, T. Ishitani*, J. Carter*, N. Hisamoto *, J. Ninomiya-Tsuji* , C. Thorpe *, D. Hamill *, K. Matsumoto *, B. Bowerman *

MeSH headings : Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Caenorhabditis elegans / enzymology; Caenorhabditis elegans / genetics; Caenorhabditis elegans / metabolism; Caenorhabditis elegans Proteins; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cell Line; Cloning, Molecular; DNA-Binding Proteins / genetics; Down-Regulation; Enzyme Activation; Gene Expression Regulation, Developmental; Genes, Helminth; High Mobility Group Proteins / genetics; Humans; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 4; MAP Kinase Kinase Kinases; Membrane Proteins / genetics; Membrane Proteins / metabolism; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Potassium Channels, Voltage-Gated; Protein Kinases / metabolism; Protein Serine-Threonine Kinases / chemistry; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Proto-Oncogene Proteins / metabolism; Sequence Homology, Amino Acid; Signal Transduction; Wnt Proteins; Zebrafish Proteins
topics (OpenAlex): Genetics, Aging, and Longevity in Model Organisms; Nuclear Receptors and Signaling; RNA Research and Splicing
Source: ORCID
Added: September 1, 2024

1999 article

The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF

Ishitani, T., Ninomiya-Tsuji, J., Nagai, S.-ichi, Nishita, M., Meneghini, M., Barker, N., … Matsumoto, K. (1999, June 1). Nature, Vol. 399, pp. 798–802.

By: T. Ishitani*, J. Ninomiya-Tsuji* , S. Nagai*, M. Nishita *, M. Meneghini *, N. Barker *, M. Waterman *, B. Bowerman * ...

Contributors: T. Ishitani*, J. Ninomiya-Tsuji* , S. Nagai*, M. Nishita *, M. Meneghini *, N. Barker *, M. Waterman *, B. Bowerman * ...

MeSH headings : Animals; COS Cells; Caenorhabditis elegans; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Cytoskeletal Proteins / antagonists & inhibitors; Cytoskeletal Proteins / genetics; Cytoskeletal Proteins / metabolism; DNA / metabolism; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; Phosphorylation; Point Mutation; Protein Binding; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Signal Transduction; TCF Transcription Factors; Trans-Activators; Transcription Factor 7-Like 2 Protein; Transcription Factors / antagonists & inhibitors; Transcription Factors / genetics; Transcription Factors / metabolism; Transfection; Xenopus; Xenopus Proteins; beta Catenin
topics (OpenAlex): Reproductive Biology and Fertility; Genetics, Aging, and Longevity in Model Organisms
Source: ORCID
Added: September 1, 2024

1999 article

The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway

Ninomiya-Tsuji, J., Kishimoto, K., Hiyama, A., Inoue, J.-ichiro, Cao, Z., & Matsumoto, K. (1999, March 1). Nature, Vol. 398, pp. 252–256.

By: J. Ninomiya-Tsuji* , K. Kishimoto*, A. Hiyama*, J. Inoue *, Z. Cao & K. Matsumoto *

Contributors: J. Ninomiya-Tsuji* , K. Kishimoto*, A. Hiyama*, J. Inoue *, Z. Cao & K. Matsumoto *

MeSH headings : Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Cell Line; Enzyme Activation; I-kappa B Kinase; Interleukin-1 / metabolism; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes / metabolism; Mutagenesis; NF-kappa B / metabolism; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases / metabolism; Proteins / metabolism; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Serine / metabolism; Signal Transduction; TNF Receptor-Associated Factor 6; Threonine / metabolism; Transfection; NF-kappaB-Inducing Kinase
topics (OpenAlex): Immune Response and Inflammation; interferon and immune responses
Source: ORCID
Added: September 1, 2024

1999 article

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

Yamaguchi, K., Nagai, S.-I., Ninomiya-Tsuji, J., Nishita, M., Tamai, K., Irie, K., … Matsumoto, K. (1999, January 4). The EMBO Journal, Vol. 18, pp. 179–187.

By: K. Yamaguchi *, S. Nagai, J. Ninomiya-Tsuji , M. Nishita, K. Tamai, K. Irie, N. Ueno, E. Nishida, H. Shibuya, K. Matsumoto

Contributors: K. Yamaguchi *, S. Nagai, J. Ninomiya-Tsuji , M. Nishita, K. Tamai, K. Irie, N. Ueno, E. Nishida, H. Shibuya, K. Matsumoto

MeSH headings : Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Apoptosis / physiology; Binding Sites / genetics; Bone Morphogenetic Protein Receptors; Bone Morphogenetic Proteins / physiology; Carrier Proteins / physiology; Gene Expression Regulation, Developmental; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase Kinases; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases / physiology; Proteins / genetics; Proteins / physiology; Receptors, Cell Surface / physiology; Receptors, Growth Factor; Receptors, Steroid / physiology; Receptors, Thyroid Hormone / physiology; Saccharomyces cerevisiae / genetics; Sequence Deletion; Signal Transduction; X-Linked Inhibitor of Apoptosis Protein; Xenopus; Xenopus Proteins
topics (OpenAlex): Pluripotent Stem Cells Research
Source: ORCID
Added: September 1, 2024

1997 journal article

Functional analyses of mammalian protein kinase C isozymes in budding yeast and mammalian fibroblasts

Genes to Cells, 2(10), 601–614. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031240976&partnerID=MN8TOARS

By: S. Nomoto, Y. Watanabe, J. Ninomiya-Tsuji , L. Yang, K. Kiuchi, M. Hagiwara, H. Hidaka, K. Matsumoto, K. Irie

Contributors: S. Nomoto, Y. Watanabe, J. Ninomiya-Tsuji , L. Yang, K. Kiuchi, M. Hagiwara, H. Hidaka, K. Matsumoto, K. Irie

www.scopus.com
Source: ORCID
Added: September 1, 2024

1997 journal article

TGF-beta signaling

Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme, 42(10 Suppl), 1517–1524. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031183774&partnerID=MN8TOARS

By: J. Ninomiya-Tsuji , K. Matsumoto & H. Shibuya

Contributors: J. Ninomiya-Tsuji , K. Matsumoto & H. Shibuya

www.scopus.com
Source: ORCID
Added: September 1, 2024

1996 article

G1 phase-specific suppression of the Cdk2 activity by ginsenoside Rh2 in cultured murine cells

Ota, T., Maeda, M., Odashima, S., Ninomiya-Tsuji, J., & Tatsuka, M. (1996, November 1). Life Sciences, Vol. 60.

By: T. Ota*, M. Maeda*, S. Odashima*, J. Ninomiya-Tsuji*  & M. Tatsuka *

Contributors: T. Ota*, M. Maeda*, S. Odashima*, J. Ninomiya-Tsuji*  & M. Tatsuka *

MeSH headings : 3T3 Cells; Animals; CDC2-CDC28 Kinases; Cells, Cultured; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases / antagonists & inhibitors; G1 Phase / drug effects; Ginsenosides; Mice; Mice, Inbred BALB C; Protein Serine-Threonine Kinases / antagonists & inhibitors; Saponins / pharmacology; Tumor Cells, Cultured
topics (OpenAlex): Ginseng Biological Effects and Applications; Cancer-related Molecular Pathways; DNA Repair Mechanisms
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: September 1, 2024

1993 journal article

Augmentation by IL-1α of tumor necrosis factor-α cytotoxicity in cells transfected with adenovirus E1A

Journal of Immunology, 150(5), 1897–1907. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027223371&partnerID=MN8TOARS

By: Y. Tsuji, J. Ninomiya-Tsuji , S. Torti & F. Torti

Contributors: Y. Tsuji, J. Ninomiya-Tsuji , S. Torti & F. Torti

www.scopus.com
Source: ORCID
Added: September 1, 2024

1993 journal article

Selective loss of CDC2 and CDK2 induction by tumor necrosis factor-α in senescent human diploid fibroblasts

Experimental Cell Research, 209(2), 175–182. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027146392&partnerID=MN8TOARS

By: Y. Tsuji, J. Ninomiya-Tsuji , S. Torti & F. Torti

Contributors: Y. Tsuji, J. Ninomiya-Tsuji , S. Torti & F. Torti

www.scopus.com
Source: ORCID
Added: September 1, 2024

1993 journal article

Tumor necrosis factor-induced c-myc expression in the absence of mitogenesis is associated with inhibition of adipocyte differentiation

Proceedings of the National Academy of Sciences of the United States of America, 90(20), 9611–9615. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027491022&partnerID=MN8TOARS

By: J. Ninomiya-Tsuji , F. Torti & G. Ringold

Contributors: J. Ninomiya-Tsuji , F. Torti & G. Ringold

www.scopus.com
Source: ORCID
Added: September 1, 2024

1992 article

Cyclin-dependent kinase 2 (cdk2) in the murine cdc2 kinaseTS mutant

Yasuda, H., Nakata, T., Kamijo, M., Honda, R., Nakamura, M., Ninomiya-Tsuji, J., … Ohba, Y. (1992, September 1). Somatic Cell and Molecular Genetics, Vol. 18, pp. 403–408.

By: H. Yasuda*, T. Nakata*, M. Kamijo*, R. Honda*, M. Nakamura*, J. Ninomiya-Tsuji* , M. Yamashita *, Y. Nagahama*, Y. Ohba*

Contributors: H. Yasuda*, T. Nakata*, M. Kamijo*, R. Honda*, M. Nakamura*, J. Ninomiya-Tsuji* , M. Yamashita *, Y. Nagahama*, Y. Ohba*

MeSH headings : Animals; CDC2 Protein Kinase / metabolism; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Cyclins / metabolism; Hot Temperature; Mice; Mutation; Protein Kinases / metabolism; Protein Serine-Threonine Kinases
topics (OpenAlex): DNA Repair Mechanisms; Cancer-related Molecular Pathways; Cancer Genomics and Diagnostics
Source: ORCID
Added: September 1, 2024

1992 article

IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc

Shibuya, H., Yoneyama, M., Ninomiya-Tsuji, J., Matsumoto, K., & Taniguchi, T. (1992, July 1). Cell, Vol. 70, pp. 57–67.

By: H. Shibuya *, M. Yoneyama *, J. Ninomiya-Tsuji* , K. Matsumoto * & T. Taniguchi*

Contributors: H. Shibuya *, M. Yoneyama *, J. Ninomiya-Tsuji* , K. Matsumoto * & T. Taniguchi*

MeSH headings : Animals; CDC2 Protein Kinase / biosynthesis; Cell Cycle / genetics; Cell Line; Cyclins / biosynthesis; Epidermal Growth Factor / pharmacology; Gene Expression Regulation / drug effects; Genes, myc / physiology; Interleukin-2 / pharmacology; Mice; Signal Transduction; Transcriptional Activation
topics (OpenAlex): Lymphoma Diagnosis and Treatment; Chronic Lymphocytic Leukemia Research
Source: ORCID
Added: September 1, 2024

1992 journal article

New human gene encoding a positive modulator of HIV Tat-mediated transactivation

Nature, 357(6380), 700–702. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026689020&partnerID=MN8TOARS

By: H. Shibuya, K. Irie, J. Ninomiya-Tsuji , M. Goebl, T. Taniguchi & K. Matsumoto

Contributors: H. Shibuya, K. Irie, J. Ninomiya-Tsuji , M. Goebl, T. Taniguchi & K. Matsumoto

www.scopus.com
Source: ORCID
Added: September 1, 2024

1991 journal article

Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation

Proceedings of the National Academy of Sciences of the United States of America, 88(20), 9006–9010. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025946804&partnerID=MN8TOARS

By: J. Ninomiya-Tsuji , S. Nomoto, H. Yasuda, S. Reed & K. Matsumoto

Contributors: J. Ninomiya-Tsuji , S. Nomoto, H. Yasuda, S. Reed & K. Matsumoto

www.scopus.com
Source: ORCID
Added: September 1, 2024

1990 journal article

A temperature-sensitive cell-cycle mutant of mammalian cells, tsJT16, is defective in a function operating soon after growth stimulation

Cell Structure and Function, 15(1), 39–45. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025276307&partnerID=MN8TOARS

By: T. Takasuka, J. Ninomiya-Tsuji , M. Sakayama, S. Ishibashi & T. Ide

Contributors: T. Takasuka, J. Ninomiya-Tsuji , M. Sakayama, S. Ishibashi & T. Ide

www.scopus.com
Source: ORCID
Added: September 1, 2024

1990 article

Nonlethal G0-ts mutant tsJT60 becomes lethal at the nonpermissive temperature after transformation: A hint for new cancer chemotherapeutics.

Tai, Y. Y., Ninomiya-Tsuji, J., Furuoku, K., Ogawa, N., Ishibashi, S., Shiroki, K., … Ide, T. (1990, January 1). Cell Structure and Function, Vol. 15, pp. 385–391.

By: Y. Tai*, J. Ninomiya-Tsuji* , K. Furuoku*, N. Ogawa *, S. Ishibashi*, K. Shiroki*, K. Segawa*, N. Tsuchida, M. Shibuya*, T. Ide*

Contributors: Y. Tai*, J. Ninomiya-Tsuji* , K. Furuoku*, N. Ogawa *, S. Ishibashi*, K. Shiroki*, K. Segawa*, N. Tsuchida, M. Shibuya*, T. Ide*

MeSH headings : Adenovirus Early Proteins; Animals; Antigens, Polyomavirus Transforming / genetics; Antineoplastic Agents / pharmacology; Carcinogens / pharmacology; Cell Division; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic / chemically induced; Cell Transformation, Neoplastic / genetics; Cell Transformation, Viral; Drug Design; Genes, Lethal; Genes, myc; Genes, ras; Methylnitronitrosoguanidine / pharmacology; Mutation; Oncogene Proteins, Viral / genetics; Oncogenes; Oncogenic Viruses / physiology; Rats; Rats, Inbred F344; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / physiology; Resting Phase, Cell Cycle; Temperature
topics (OpenAlex): Virus-based gene therapy research; RNA Interference and Gene Delivery; CAR-T cell therapy research
Source: ORCID
Added: September 1, 2024

1988 article

A cell cycle G0-ts mutant, tsJT60, becomes lethal at the nonpermissive temperature after transformation with adenovirus 12 E1B 19K mutant

Tai, Y. Y., Goto, Y., Ninomiya-Tsuji, J., Kameoka, Y., Ishibashi, S., Shiroki, K., & Ide, T. (1988, November 1). Experimental Cell Research, Vol. 179, pp. 50–57.

By: Y. Tai*, Y. Goto*, J. Ninomiya-Tsuji* , Y. Kameoka*, S. Ishibashi*, K. Shiroki*, T. Ide*

Contributors: Y. Tai*, Y. Goto*, J. Ninomiya-Tsuji* , Y. Kameoka*, S. Ishibashi*, K. Shiroki*, T. Ide*

MeSH headings : Adenoviridae; Animals; Cell Division; Cell Fusion; Cell Line; Cell Transformation, Viral; DNA / metabolism; Fibroblasts / cytology; Genes, Lethal; Interphase; Mutation; Phenotype; Rats; Rats, Inbred F344; Temperature
topics (OpenAlex): Virus-based gene therapy research; Viral Infectious Diseases and Gene Expression in Insects; CAR-T cell therapy research
Source: ORCID
Added: September 1, 2024

1987 article

Bypass of the ts block of tsJT60, a G0-specific ts mutant from rat fibroblasts, by fetal bovine serum and epidermal growth factor.

Ninomiya-Tsuji, J., Nakahara, Y., Ito, C., Akiyama, T., Ishibashi, S., & Ide, T. (1987, January 1). Cell Structure and Function, Vol. 12, pp. 421–432.

By: J. Ninomiya-Tsuji* , Y. Nakahara*, C. Ito*, T. Akiyama *, S. Ishibashi* & T. Ide

Contributors: J. Ninomiya-Tsuji* , Y. Nakahara*, C. Ito*, T. Akiyama *, S. Ishibashi* & T. Ide

MeSH headings : Animals; Blood; Cattle; Cell Division / drug effects; Culture Media; DNA Replication / drug effects; Epidermal Growth Factor / pharmacology; Fetus; Interphase / drug effects; Kinetics; Mutation; Rats; Temperature
topics (OpenAlex): Virus-based gene therapy research; RNA Interference and Gene Delivery; RNA Research and Splicing
Source: ORCID
Added: September 1, 2024

1987 journal article

Colchicine activates cell cycle-dependent genes in growth-arrested rat 3Y1 cells

Experimental Cell Research, 173(1), 294–298.

By: M. Miura*, J. Ninomiya-Tsuji* , Y. Tsuji* , S. Ishibashi* & T. Ide*

Contributors: M. Miura*, J. Ninomiya-Tsuji* , Y. Tsuji* , S. Ishibashi* & T. Ide*

MeSH headings : Animals; Cell Cycle / drug effects; Colchicine / pharmacology; Gene Expression Regulation / drug effects; Histones / genetics; Ornithine Decarboxylase / genetics; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-myc; Rats
topics (OpenAlex): RNA regulation and disease; RNA Interference and Gene Delivery; Polyamine Metabolism and Applications
Sources: ORCID, Crossref, NC State University Libraries
Added: September 1, 2024

1987 journal article

Entrance of SV40-transformed Cells into g0 Phase as Revealed by a Study Using the g0-specific ts mutant tsjt60

Cancer Research, 47(22), 6028–6032. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023589313&partnerID=MN8TOARS

By: J. Ninomiya-Tsuji , S. Ishibashi & T. Ide

Contributors: J. Ninomiya-Tsuji , S. Ishibashi & T. Ide

www.scopus.com
Source: ORCID
Added: September 1, 2024

1987 article

Epidermal growth factor has a unique effect in combination with fetal bovine serum to bypass the ts-block of Go-specific ts mutant tsJT60

Ninomiya-Tsuji, J., Nakahara, Y., Ito, C., Akiyama, T., Ishibashi, S., & Ide, T. (1987, July 1). Experimental Cell Research, Vol. 171, pp. 86–93.

By: J. Ninomiya-Tsuji* , Y. Nakahara*, C. Ito*, T. Akiyama *, S. Ishibashi* & T. Ide*

Contributors: J. Ninomiya-Tsuji* , Y. Nakahara*, C. Ito*, T. Akiyama *, S. Ishibashi* & T. Ide*

MeSH headings : Animals; Blood; Cell Division; Cell Line; Culture Media; DNA / biosynthesis; Epidermal Growth Factor / pharmacology; Growth Substances / pharmacology; Insulin-Like Growth Factor I / metabolism; Interphase; Kinetics; Mutation; Rats; Temperature
topics (OpenAlex): Pancreatic function and diabetes; Receptor Mechanisms and Signaling; Reproductive Biology and Fertility
Source: ORCID
Added: September 1, 2024

1987 article

Induction of cellular DNA synthesis in G0-specific ts mutant, tsJT60, following Infection with SV40 and adenoviruses

Ninomiya-Tsuji, J., Goto, Y., Ishibashi, S., Shiroki, K., & Ide, T. (1987, August 1). Experimental Cell Research, Vol. 171, pp. 509–512.

By: J. Ninomiya-Tsuji* , Y. Goto*, S. Ishibashi*, K. Shiroki* & T. Ide*

Contributors: J. Ninomiya-Tsuji* , Y. Goto*, S. Ishibashi*, K. Shiroki* & T. Ide*

MeSH headings : Adenoviruses, Human / physiology; Animals; Cell Line; DNA / biosynthesis; Hot Temperature; Interphase; Mutation; Rats; Simian virus 40 / physiology
topics (OpenAlex): Virus-based gene therapy research; RNA Interference and Gene Delivery; CRISPR and Genetic Engineering
Source: ORCID
Added: September 1, 2024

1987 article

tsJT60, a cell cycle G0-ts mutant, becomes lethal at non-permissive temperature by transformation with adenovirus 5 when the expression of E1B gene is lacking

Goto, Y., Ninomiya-Tsuji, J., Tanonaka, K., Ishibashi, S., Shiroki, K., & Ide, T. (1987, June 1). Experimental Cell Research, Vol. 170, pp. 491–498.

By: Y. Goto*, J. Ninomiya-Tsuji* , K. Tanonaka *, S. Ishibashi*, K. Shiroki* & T. Ide*

Contributors: Y. Goto*, J. Ninomiya-Tsuji* , K. Tanonaka *, S. Ishibashi*, K. Shiroki* & T. Ide*

MeSH headings : Adenoviridae / physiology; Adenovirus Early Proteins; Animals; Cell Cycle; Cell Transformation, Viral; Genes, Lethal; Genetic Complementation Test; Interphase; Mutation; Oncogene Proteins, Viral / physiology; Rats; Temperature
topics (OpenAlex): Virus-based gene therapy research; Viral Infectious Diseases and Gene Expression in Insects; CRISPR and Genetic Engineering
Source: ORCID
Added: September 1, 2024

1986 article

Defect in prereplicative phase of G0-specific ts mutant, tsJT60

Ninomiya-Tsuji, J., Goto, Y., Ishibashi, S., & Ide, T. (1986, July 1). Experimental Cell Research, Vol. 165, pp. 191–198.

By: J. Ninomiya-Tsuji* , Y. Goto*, S. Ishibashi* & T. Ide*

Contributors: J. Ninomiya-Tsuji* , Y. Goto*, S. Ishibashi* & T. Ide*

MeSH headings : Animals; Cell Cycle; Cell Division; Cell Line; Interphase; Kinetics; Macromolecular Substances; Mutation; Polyribosomes / physiology; Proteins / analysis; RNA / analysis; Rats
topics (OpenAlex): Protein Structure and Dynamics; Enzyme Structure and Function; Bacterial Genetics and Biotechnology
Source: ORCID
Added: September 1, 2024

1986 article

Expression of growth-regulated genes in TSJT60 cells, a temperature-sensitive mutant of the cell cycle

Ide, T., Ninomiya-Tsuji, J., Ferrari, S., Philiponis, V., & Baserga, R. (1986, November 4). Biochemistry, Vol. 25, pp. 7041–7046.

By: T. Ide, J. Ninomiya-Tsuji* , S. Ferrari, V. Philiponis & R. Baserga

Contributors: T. Ide, J. Ninomiya-Tsuji* , S. Ferrari, V. Philiponis & R. Baserga

MeSH headings : Animals; Cell Cycle; Cell Line; Clone Cells; DNA Replication; Genes; Kinetics; Mutation; Oncogenes; Rats; Rats, Inbred F344; Temperature
topics (OpenAlex): Viral Infectious Diseases and Gene Expression in Insects; Heat shock proteins research; RNA Research and Splicing
Source: ORCID
Added: September 1, 2024

1986 article

Failure in S6 protein phosphorylation by serum stimulatio of senescent human diploid fibroblasts, TIG-1

Kihara, F., Ninomiya-Tsuji, J., Ishibashi, S., & Ide, T. (1986, November 1). Mechanisms of Ageing and Development, Vol. 37, pp. 27–40.

By: F. Kihara*, J. Ninomiya-Tsuji* , S. Ishibashi* & T. Ide*

Contributors: F. Kihara*, J. Ninomiya-Tsuji* , S. Ishibashi* & T. Ide*

MeSH headings : Blood; Cell Survival; Electrophoresis, Polyacrylamide Gel; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; Molecular Weight; Phosphorylation; Ribosomal Protein S6; Ribosomal Proteins / metabolism
topics (OpenAlex): Telomeres, Telomerase, and Senescence; Ubiquitin and proteasome pathways; Immunotherapy and Immune Responses
Source: ORCID
Added: September 1, 2024

1986 article

Isolation of ts mutant cells which arrest in G1/G0 phase at the non-permissive temperature in the presence of appropriate growth factors from a Fischer rat cell line, 3Y1

Tanonaka, K., Ninomiya-Tsuji, J., Ishibashi, S., & Ide, T. (1986, August 1). Experimental Cell Research, Vol. 165, pp. 337–344.

By: K. Tanonaka *, J. Ninomiya-Tsuji* , S. Ishibashi* & T. Ide*

Contributors: K. Tanonaka *, J. Ninomiya-Tsuji* , S. Ishibashi* & T. Ide*

MeSH headings : Animals; Cell Cycle; Cell Line; DNA Replication; Epidermal Growth Factor / physiology; Genetic Complementation Test; Growth Substances / physiology; Insulin / physiology; Mutation; Phenotype; Rats; Temperature
topics (OpenAlex): CRISPR and Genetic Engineering; Virus-based gene therapy research; Pancreatic function and diabetes
Source: ORCID
Added: September 1, 2024

1984 article

Isolation of a G0-specific ts mutant from a Fischer rat cell line, 3Y1

Ide, T., Ninomiya, J., & Ishibashi, S. (1984, January 1). Experimental Cell Research, Vol. 150, pp. 60–67.

By: T. Ide*, J. Ninomiya*  & S. Ishibashi*

Contributors: T. Ide*, J. Ninomiya*  & S. Ishibashi*

MeSH headings : Animals; Blood; Cell Count; Cell Division; Cell Line; Cell Separation; Clone Cells; Culture Media; DNA / biosynthesis; Interphase; Mutation; Phenotype; Rats; Temperature; Trypsin / pharmacology
topics (OpenAlex): CRISPR and Genetic Engineering; Genomics and Chromatin Dynamics; RNA Interference and Gene Delivery
Source: ORCID
Added: September 1, 2024

1984 journal article

Isolation of a G0-specific ts mutant from a Fischer rat cell line, 3Y1.

Exp. Cell Res.

Jun Ninomiya-Tsuji

Source: ORCID
Added: September 1, 2024

Employment

Updated: March 2nd, 2026 19:54

2013 - present

North Carolina State University Raleigh, NC, US
Professor Biological Sciences

2008 - 2013

North Carolina State University Raleigh, NC, US
Associate Professor Environmental and Molecular Toxicology

2002 - 2008

North Carolina State University Raleigh, NC, US
Assistant Professor Environmental and Molecular Toxicology

Funding History

Funding history based on the linked ORCID record. Updated: November 9th, 2021 11:45

grant January 1, 2021 - December 31, 2025
TAK1 signaling pathways
National Institute of General Medical Sciences
grant July 1, 2020 - June 30, 2023
Consequences and significance of TAK1 inhibition in macrophages
National Institute of General Medical Sciences
grant January 1, 2019
TAK1 as a target of Alzheimer’s disease
Alzheimer's Association
grant August 1, 2015 - July 31, 2019
TAK1 regulation of metabolism
National Institute of General Medical Sciences
grant August 1, 2013 - August 1, 2014
Role of TAB1-TAK1 Signaling in Tumor-Associated Macrophage Survival
National Cancer Institute
grant September 30, 2009 - August 31, 2012
TAK1 regulation of reactive oxygen species and inflammation
National Institute of General Medical Sciences
grant July 1, 2006 - June 1, 2008
Role of TAK1 in intestinal inflammation and cancer
Crohn's and Colitis Foundation of America
grant August 1, 2004 - April 30, 2007
ROLE OF TAK1 IN RANKL SIGNALING PATHWAY
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant April 1, 2004 - March 31, 2016
TAK1 signaling network in tissue homeostasis
National Institute of General Medical Sciences

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