Jun Ninomiya-Tsuji
Also known as: Jun Tsuji
TAK1, MAP3K7, inflammatory signaling
Works (110)
Updated: December 4th, 2024 05:01
2024 article
TAK1 inhibition translocates pore-forming proteins, MLKL and gasdermins into mitochondria to generate reactive oxygen species
Gonzalez-Calderon, R., Lopez-Perez, W., Sai, K., & Ninomiya-Tsuji, J. (2024, March). JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 300, pp. S555–S555.
open access via www.jbc.org (publisher PDF)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2024
2024 article
The Mechanism and Roles of TAK1 hyperactivation in the Alzheimer's Disease Mouse Model
Nakanishi-Hester, A., Sai, K., & Ninomiya-Tsuji, J. (2024, March). JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 300, pp. S556–S556.
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2024
2023 journal article
Aberrantly activated TAK1 links neuroinflammation and neuronal loss in Alzheimer?s disease mouse models
JOURNAL OF CELL SCIENCE, 136(6).
author keywords: Alzheimer?s disease; Cell death; Inflammation; TAK1
MeSH headings : Animals; Mice; Alzheimer Disease / genetics; Calcium; Cytokines / metabolism; Neuroinflammatory Diseases; Signal Transduction / physiology
TL;DR:
It is reported that compound stimulation with the neurotoxic factors TNF and glutamate aberrantly activates neuronal TAK1 (also known as MAP3K7), which promotes the pathogenesis of AD in mouse models and provides a molecular mechanism linking cytokines, Ca2+ signaling and neuronal necroptosis in AD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 30, 2023
2021 journal article
TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(25).
Contributors: W. López-Pérez n, K. Sai n, Y. Sakamachi n, C. Parsons n, S. Kathariou n & n
author keywords: TAK1; ROS; mitochondria; intracellular bacteria
MeSH headings : Animals; Bacteria / growth & development; Caspase 3 / metabolism; Colony Count, Microbial; Hydrogen Sulfide / pharmacology; Intracellular Space / microbiology; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Mice; Mitochondria / metabolism; Reactive Oxygen Species / metabolism; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Salmonella / drug effects; Salmonella / growth & development; Yersinia / drug effects
TL;DR:
A previously unrecognized host defense mechanism is revealed, which is initiated by host recognition of pathogen-induced impairment in a host protein, TAK1, but not directly of pathogens.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 12, 2021
2019 journal article
Coordinating Tissue Regeneration Through Transforming Growth Factor-beta Activated Kinase 1 Inactivation and Reactivation
STEM CELLS, 37(6), 766–778.
Contributors: H. Hsieh, S. Agarwal *, D. Cholok *, S. Loder *, K. Kaneko *, A. Huber *, M. Chung *, K. Ranganathan *
author keywords: Cellular proliferation; Differentiation; Progenitor cells; Proliferation; Stem; progenitor cell; Tissue regeneration
MeSH headings : Animals; Bone Regeneration / drug effects; Bone Regeneration / genetics; Cell Differentiation / drug effects; Cell Proliferation / drug effects; DNA Nucleotidyltransferases / genetics; DNA Nucleotidyltransferases / metabolism; Female; Founder Effect; Fractures, Bone / drug therapy; Fractures, Bone / enzymology; Fractures, Bone / genetics; Fractures, Bone / pathology; Gene Expression Regulation; Integrases / genetics; Integrases / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / genetics; Male; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / enzymology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Osteoblasts / cytology; Osteoblasts / drug effects; Osteoblasts / enzymology; Primary Cell Culture; Protein Kinase Inhibitors / pharmacology; Signal Transduction; Skull / drug effects; Skull / injuries; Skull / metabolism; Wound Healing / drug effects; Wound Healing / genetics
TL;DR:
It is demonstrated that loss of transforming growth factor‐β activated kinase 1 (TAK1) signaling reduces inappropriate tissue formation (heterotopic ossification) through reduced cellular differentiation, and the importance of both the “drug on” and "drug off" states during regenerative therapy is revealed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 22, 2019
2019 journal article
Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing
JOURNAL OF CELL BIOLOGY, 218(6), 1994–2005.
Contributors: K. Sai n, C. Parsons n, J. House n , S. Kathariou n & n
MeSH headings : Animals; Female; Humans; Listeria / growth & development; Listeria / immunology; Listeria / metabolism; Listeriosis / metabolism; Listeriosis / microbiology; Listeriosis / pathology; Listeriosis / prevention & control; Mice; Mice, Inbred C57BL; Mice, Knockout; Necroptosis; Protein Kinases / physiology; Receptor-Interacting Protein Serine-Threonine Kinases / genetics; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Receptor-Interacting Protein Serine-Threonine Kinases / physiology
TL;DR:
The RIPK3-MLKL pathway protects epithelial cells from Listeria monocytogenes invasion but does not induce its oligomerization or necroptotic cell death, and instead targets intracellular bacteria and suppresses their replication.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2019
2018 journal article
Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death
GENESIS, 56(3).
Contributors: X. Liu *, S. Hayano *, H. Pan*, M. Inagaki n, n , H. Sun *, Y. Mishina *
author keywords: apoptosis; facial prominence; MAP kinase; nasal septum; Smad signaling
MeSH headings : Animals; Apoptosis / genetics; Biomarkers; Bone Morphogenetic Protein Receptors, Type I / genetics; Bone Morphogenetic Protein Receptors, Type I / metabolism; Cell Death / genetics; Craniofacial Abnormalities / diagnosis; Craniofacial Abnormalities / genetics; Genetic Association Studies; Genotype; Gestational Age; Immunohistochemistry; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Transgenic; Mutation; Phenotype; Signal Transduction; Smad Proteins / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
It is suggested that deletion of Tak1 aggravates the craniofacial deformities of the caBmpr1a mutants by increasing p53 and phospho‐p38 at different stage of embryogenesis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Erratum: Noncanonical cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGFβ-activated kinase 1
Scientific Reports, 7(1).
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2017 journal article
Noncanocial cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGF beta-activated kinase 1
SCIENTIFIC REPORTS, 7(1).
Contributors: S. Mihaly n, Y. Sakamachi n, n & S. Morioka n
TL;DR:
This work identified a previously uncharacterized cell death pathway regulated by TAK1, which is unexpectedly provoked by inhibition of caspase activity and necroptosis cascades and surprisingly found that caspases and RIPK3 inhibitions do not completely suppress cell death in Tak1-deficient cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
TAK1 regulates resident macrophages by protecting lysosomal integrity
CELL DEATH & DISEASE, 8(2).
Contributors: Y. Sakamachi n, S. Morioka n, S. Mihaly n, G. Takaesu n, J. Foley *, M. Fessler *, n
MeSH headings : Animals; Cell Death / physiology; Cell Survival / physiology; Embryonic Development / physiology; Lung / metabolism; Lysosomes / metabolism; MAP Kinase Kinase Kinases / metabolism; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Protective Agents / metabolism; Receptors, Tumor Necrosis Factor, Type I / metabolism; Signal Transduction / physiology; Thymocytes / physiology; Thymus Gland / metabolism; Toll-Like Receptors / metabolism
TL;DR:
The results suggest that autocrine and potentially paracrine TNF kills Tak1-deficient macrophages during development, and reveal that TAK1 signaling maintains proper macrophage populations through protecting lysosomal integrity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1
ANTIOXIDANTS & REDOX SIGNALING, 25(17), 953–964.
Contributors: K. Hashimoto n, A. Simmons*, R. Kajino-Sakamoto*, Y. Tsuji n & n
author keywords: intestine; TAK1; Nrf2; Keap1; p62/SQSTM
MeSH headings : Animals; Antioxidants / metabolism; Cell Line; Gene Expression Regulation; Humans; Intestinal Mucosa / metabolism; Kelch-Like ECH-Associated Protein 1 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Models, Biological; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress; Protein Binding; Proteolysis; Reactive Oxygen Species / metabolism; Sequestosome-1 Protein / metabolism
TL;DR:
The results identify for the first time that TAK1 is a modulator of p62/SQSTM1-dependent Keap1 degradation and maintains the steady state-level of Nrf2, important for homeostatic antioxidant protection in the intestinal epithelium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus
Journal of Cell Science, 129(9), 1855–1865.
Contributors: K. Sai n, S. Morioka n, G. Takaesu n, N. Muthusamy n, H. Ghashghaei n, H. Hanafusa *, K. Matsumoto *, n
author keywords: TAK1; Endoplasmic reticulum stress; Leptin; Hypothalamus; Obesity
MeSH headings : Animals; Dietary Fats / adverse effects; Dietary Fats / pharmacology; Endoplasmic Reticulum Stress; Hyperphagia / chemically induced; Hyperphagia / genetics; Hyperphagia / metabolism; Hyperphagia / pathology; Hypothalamus / metabolism; Hypothalamus / pathology; Leptin / genetics; Leptin / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Obesity / chemically induced; Obesity / genetics; Obesity / metabolism; Obesity / pathology; Sterol Regulatory Element Binding Proteins / genetics; Sterol Regulatory Element Binding Proteins / metabolism
TL;DR:
It is found that deletion of Tak1 increased ER volume and facilitated ER-stress tolerance in cultured cells, which was mediated by upregulation of sterol-regulatory-element-binding protein (SREBP)-dependent lipogenesis and central nervous system (CNS) deletion upregulated SREBP-target lipogenic genes and blocked ER stress in the hypothalamus.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2016 journal article
TAK1 regulates Paneth cell integrity partly through blocking necroptosis
CELL DEATH & DISEASE, 7(4).
Contributors: A. Simmons n, R. Kajino-Sakamoto n & n
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Apoptosis / drug effects; Bacteria / drug effects; Bacteria / genetics; DNA, Bacterial / genetics; DNA, Bacterial / metabolism; Intestinal Mucosa / metabolism; Intestines / microbiology; Intestines / pathology; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88 / deficiency; Myeloid Differentiation Factor 88 / genetics; Myeloid Differentiation Factor 88 / metabolism; Necrosis; Paneth Cells / drug effects; Paneth Cells / metabolism; Paneth Cells / pathology; RNA, Messenger / metabolism; Reactive Oxygen Species / metabolism; Real-Time Polymerase Chain Reaction; Receptor-Interacting Protein Serine-Threonine Kinases / genetics; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Signal Transduction; Toll-Like Receptors / metabolism; Up-Regulation
TL;DR:
It is found that depletion of gut bacteria or myeloid differentiation factor 88 (Myd88), a mediator of bacteria-derived cell signaling, reduced ROS but did not block Paneth cell loss, suggesting that gut bacteria are the cause of ROS accumulation but bacteria-induced ROS are not the cause.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2016 journal article
TAK1 regulates hepatic lipid homeostasis through SREBP
ONCOGENE, 35(29), 3829–3838.
Contributors: S. Morioka n, K. Sai n, E. Omori n, Y. Ikeda n, K. Matsumoto * & n
MeSH headings : Animals; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / metabolism; Cell Line; Fatty Liver / genetics; Fatty Liver / metabolism; Female; HEK293 Cells; Hep G2 Cells; Hepatocytes / metabolism; Homeostasis; Humans; Immunoblotting; Lipid Metabolism; Liver / metabolism; Liver Neoplasms / genetics; Liver Neoplasms / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Male; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Protein Binding; RNA Interference; Risk Factors; Sterol Regulatory Element Binding Proteins / genetics; Sterol Regulatory Element Binding Proteins / metabolism
TL;DR:
It is demonstrated that SREBPs are regulated by a previously uncharacterized mechanism through transforming growth factor-β activated kinase 1 (TAK1), a signaling molecule of inflammation, which critically contributes to the maintenance of liver homeostasis to prevent steatosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
Activated Macrophage Survival Is Coordinated by TAK1 Binding Proteins
PLOS ONE, 9(4).
Contributors: S. Mihaly n, S. Morioka n, n & G. Takaesu n
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Cell Death / drug effects; Cell Death / immunology; Cell Survival / genetics; GTPase-Activating Proteins / antagonists & inhibitors; GTPase-Activating Proteins / genetics; GTPase-Activating Proteins / metabolism; Gene Deletion; Lipopolysaccharides / immunology; MAP Kinase Kinase Kinases / genetics; Macrophage Activation / genetics; Macrophage Activation / immunology; Macrophages / immunology; Macrophages / metabolism; Mice; Mice, Knockout
TL;DR:
It is reported that TGFβ- activated kinase (TAK1) activators, TAK1-binding protein 1 (TAB1) and TAK2, are critical molecules in the regulation of activated macrophage survival, and shows that TAB1 and TAB2 were redundantly involved in LPS-induced Taker1 activation in macrophages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
TAK1 Binding Protein 2 Is Essential for Liver Protection from Stressors
PLOS ONE, 9(2).
Contributors: Y. Ikeda n, S. Morioka n, K. Matsumoto * & n
MeSH headings : Adaptor Proteins, Signal Transducing / physiology; Alkylating Agents / toxicity; Animals; Apoptosis / drug effects; Blotting, Western; Chemical and Drug Induced Liver Injury / etiology; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / prevention & control; Diethylnitrosamine / toxicity; Electrophoretic Mobility Shift Assay; Female; Hepatocytes / drug effects; Hepatocytes / metabolism; Hepatocytes / pathology; Integrases / metabolism; Lipopolysaccharides / toxicity; MAP Kinase Kinase Kinases / physiology; Male; Mice; Mice, Knockout; Mice, Transgenic; RNA, Messenger / genetics; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
It is demonstrated that TAB2 is a sensor of stress conditions in the liver and functions to protect the liver by activating the TAK1 pathway, and a chemical stressor induced greatly exaggerated liver injury in hepatocyte-specific Tab2-deficient mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 review
TAK1 control of cell death
[Review of ]. CELL DEATH AND DIFFERENTIATION, 21(11), 1667–1676.
Contributors: S. Mihaly n, n & S. Morioka n
MeSH headings : Animals; Apoptosis / physiology; Cell Death; Cell Survival; Homeostasis; Humans; MAP Kinase Kinase Kinases / metabolism; Mice; Mitogen-Activated Protein Kinases / metabolism; NF-kappa B / metabolism; Necrosis / metabolism; Signal Transduction
TL;DR:
This review summarizes the consequences of TAK1 deficiency in different cell and tissue types from the perspective of cell death and also focuses on the mechanism by which Tak1 complex inhibits or promotes programmed cell death.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2014 journal article
TAK1 kinase switches cell fate from apoptosis to necrosis following TNF stimulation
The Journal of Cell Biology, 204(4), 607–623.
Contributors: S. Morioka n, P. Broglie n, Omori, Y. Ikeda n, G. Takaesu n, K. Matsumoto *, n
MeSH headings : Adaptor Proteins, Signal Transducing / physiology; Animals; Apoptosis / drug effects; Blotting, Western; Cell Cycle; Chemical and Drug Induced Liver Injury / metabolism; Chemical and Drug Induced Liver Injury / pathology; Flow Cytometry; Humans; Immunoprecipitation; Integrases / metabolism; Lipopolysaccharides / toxicity; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Necrosis; Phosphorylation; RNA, Small Interfering / genetics; Receptor-Interacting Protein Serine-Threonine Kinases / antagonists & inhibitors; Receptor-Interacting Protein Serine-Threonine Kinases / physiology; Signal Transduction; Tumor Necrosis Factor-alpha / pharmacology
TL;DR:
Activation of the TAK1 kinase drives RIPK3-dependent necrosis and inhibits apoptosis downstream of TNF-α stimulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, ORCID
Added: February 24, 2020
2014 journal article
Tak1, Smad4 and Trim33 redundantly mediate TGF-beta 3 signaling during palate development
DEVELOPMENTAL BIOLOGY, 398(2), 231–241.
Contributors: J. Lane*, K. Yumoto*, M. Azhar *, n , M. Inagaki n, Y. Hu*, C. Deng *, J. Kim *, Y. Mishina *, V. Kaartinen *
author keywords: TGF-beta 3 signaling; Palatogenesis; Tak1; Smad4; Trim33
MeSH headings : Animals; Apoptosis / genetics; Cell Fusion; Cell Proliferation; Crosses, Genetic; Embryo, Mammalian / metabolism; Enzyme Activation; Epithelial Cells / metabolism; Epithelium / metabolism; Female; Gene Deletion; Gene Expression Regulation, Developmental; MAP Kinase Kinase Kinases / metabolism; Male; Matrix Metalloproteinase 13 / metabolism; Mice, Knockout; Models, Biological; Mutation / genetics; Organ Specificity; Palate / abnormalities; Palate / embryology; Palate / enzymology; Palate / metabolism; Signal Transduction; Smad4 Protein / metabolism; Transcription Factors / metabolism; Transforming Growth Factor beta3 / metabolism
TL;DR:
The data reveal added complexity in TGF-β signaling during palatogenesis and demonstrate that functionally redundant pathways involving Smad4, Tak1 and Trim33 regulate palatal epithelial fusion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
Kinase-Independent Feedback of the TAK1/TAB1 Complex on BCL10 Turnover and NF-kappa B Activation
MOLECULAR AND CELLULAR BIOLOGY, 33(6), 1149–1163.
Contributors: M. Moreno-García*, K. Sommer *, H. Rincon-Arano*, M. Brault*, n , L. Matesic *, D. Rawlings *
MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Animals; B-Lymphocytes / metabolism; CARD Signaling Adaptor Proteins / metabolism; Cell Line; Chickens; Endosomal Sorting Complexes Required for Transport / metabolism; HEK293 Cells; Humans; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Inbred C57BL; NF-kappa B / metabolism; Protein Kinase C / metabolism; Protein Kinase C beta; Proteolysis; Receptors, Antigen / metabolism; Signal Transduction; T-Lymphocytes / metabolism; Ubiquitin-Protein Ligases / metabolism; Ubiquitination
TL;DR:
By directly promoting BCL10 degradation, TAK1 counterbalances NF-κB and JNK signals essential for the activation and survival of lymphocytes and CARMA1-addicted lymphoma types.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2013 journal article
TGF-beta-activated Kinase 1 (Tak1) Mediates Agonist-induced Smad Activation and Linker Region Phosphorylation in Embryonic Craniofacial Neural Crest-derived Cells
JOURNAL OF BIOLOGICAL CHEMISTRY, 288(19), 13467–13480.
Contributors: K. Yumoto*, P. Thomas*, J. Lane*, K. Matsuzaki*, M. Inagaki n, n , G. Scott*, M. Ray*
MeSH headings : Amino Acid Motifs; Animals; Cells, Cultured; Cleft Palate / enzymology; Cleft Palate / genetics; Ectoderm / cytology; Female; Gene Expression Regulation, Developmental; Head / embryology; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / physiology; Male; Mandible / abnormalities; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases / metabolism; Neural Crest / cytology; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases / metabolism; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta / metabolism; Signal Transduction; Smad Proteins / metabolism; Smad Proteins, Receptor-Regulated / metabolism; TGF-beta Superfamily Proteins / physiology; Wnt1 Protein / genetics; Wnt1 Protein / metabolism
TL;DR:
It is suggested that in neural crest-derived ecto-mesenchymal cells, Tak1 provides a critical point of intersection in a complex dialogue between the canonical and noncanonical arms of TGF-β superfamily signaling required for normal craniofacial development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2012 journal article
Epithelial transforming growth factor -activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species
Proceedings of the National Academy of Sciences, 109(9), 3365–3370.
Contributors: E. Omori n, M. Inagaki n, Y. Mishina *, K. Matsumoto * & n
MeSH headings : Adaptor Proteins, Signal Transducing / deficiency; Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Enzyme Activation; Epidermis / enzymology; Epithelial Cells / enzymology; Intestinal Mucosa / enzymology; Keratinocytes / enzymology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Oxidation-Reduction; Oxidative Stress; Phenotype; Phosphorylation; Protein Processing, Post-Translational; Reactive Oxygen Species / metabolism; Signal Transduction
TL;DR:
It is demonstrated that epithelial TAK1 activity is regulated through two unique, TAB1-dependent basal and TAB2-mediated stimuli-dependent mechanisms, which are dependent on each other.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 28, 2020
2012 journal article
TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms
PLoS ONE, 7(11), e51073.
Contributors: G. Takaesu *, M. Inagaki n, K. Takubo *, Y. Mishina *, P. Hess n , G. Dean n, A. Yoshimura *, K. Matsumoto *, T. Suda *, n
Ed(s): M. Tjwa
MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Animals; Antigens, Surface / metabolism; Bone Marrow Cells / enzymology; Cell Death; Cell Proliferation; Chimerism; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / enzymology; Humans; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Receptors, Tumor Necrosis Factor, Type I / deficiency; Receptors, Tumor Necrosis Factor, Type I / metabolism; Time Factors; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
The results indicate that TAB1- or TAB2-dependent activation of TAK1 is required for maintenance of the hematopoietic system through two mechanisms: one is prevention of TNF-dependent cell death and the other is T NF-independent maintenance of long-term HSC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2012 journal article
TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration
Blood, 120(18), 3846–3857.
Contributors: S. Morioka n, M. Inagaki n, Y. Komatsu *, Y. Mishina *, K. Matsumoto * & n
Source: ORCID
Added: September 1, 2024
2011 journal article
Inhibition of autophagy by TAB2 and TAB3
EMBO JOURNAL, 30(24), 4908–4920.
Contributors: A. Criollo *, M. Niso-Santano *, S. Malik *, M. Michaud*, E. Morselli *, G. Mariño *, S. Lachkar *, A. Arkhipenko *
author keywords: Beclin 1 interactome; mTOR; p53; pifithrin alpha; rapamycin; stress response
TL;DR:
The results point to the existence of an autophagy‐stimulatory ‘switch’ whereby TAB2 and TAB3 abandon inhibitory interactions with Beclin 1 to engage in a stimulatory liaison with TAK1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2011 journal article
Non-canonical beta-catenin degradation mediates reactive oxygen species-induced epidermal cell death
ONCOGENE, 30(30), 3336–3344.
Contributors: E. Omori n, K. Matsumoto * & n
author keywords: apoptosis; beta-catenin; caspase; epidermis; reactive oxygen species
MeSH headings : Animals; Apoptosis / drug effects; Caspases / metabolism; Cell Adhesion / drug effects; Enzyme Activation / drug effects; Epidermal Cells; Epidermis / drug effects; Epidermis / enzymology; Epidermis / metabolism; HEK293 Cells; Humans; Mice; Reactive Oxygen Species / pharmacology; beta Catenin / metabolism
TL;DR:
Results indicate that a feed-forward loop consisting of ROS, caspases activation and β-catenin degradation induces epidermal cell death.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2010 journal article
Ablation of TAK1 Upregulates Reactive Oxygen Species and Selectively Kills Tumor Cells
Cancer Research, 70(21), 8417–8425.
Contributors: E. Omori n, K. Matsumoto n, S. Zhu n, R. Smart n & n
MeSH headings : 9,10-Dimethyl-1,2-benzanthracene / toxicity; Animals; Apoptosis; Blotting, Western; Carcinogens / toxicity; Cell Proliferation; Gene Deletion; Integrases / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Papilloma / chemically induced; Papilloma / metabolism; Papilloma / pathology; RNA, Messenger / genetics; RNA, Small Interfering / pharmacology; Reactive Oxygen Species / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Skin / metabolism; Skin / pathology; Skin Neoplasms / chemically induced; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Up-Regulation
TL;DR:
TAK1 kinase could be a new and effective molecular target for ROS-based tumor killing and is examined whether ablation of TAK1 in preexisting skin tumors could cause an increase in ROS and result in tumor cell death.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2010 journal article
Regulation of Genotoxic Stress Response by Homeodomain-interacting Protein Kinase 2 through Phosphorylation of Cyclic AMP Response Element-binding Protein at Serine 271
MOLECULAR BIOLOGY OF THE CELL, 21(16), 2966–2974.
Contributors: K. Sakamoto n, B. Huang n, K. Iwasaki n, K. Hailemariam n, n & Y. Tsuji n
MeSH headings : Animals; Antineoplastic Agents, Phytogenic / pharmacology; Blotting, Western; Brain-Derived Neurotrophic Factor / genetics; Brain-Derived Neurotrophic Factor / metabolism; CREB-Binding Protein / genetics; CREB-Binding Protein / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cell Line, Tumor; Cells, Cultured; Cyclic AMP Response Element-Binding Protein / genetics; Cyclic AMP Response Element-Binding Protein / metabolism; DNA Damage; Embryo, Mammalian / cytology; Etoposide / pharmacology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; HEK293 Cells; Humans; K562 Cells; Mice; Mice, Knockout; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; RNA Interference; Serine / genetics; Serine / metabolism; Transcription, Genetic / drug effects; Two-Hybrid System Techniques
TL;DR:
Homeodomain-interacting protein kinase 2 is a new CREB kinase for phosphorylation at Ser-271 but not Ser-133 in genotoxic stress and activates CREB transactivation function including brain-derived neurotrophic factor (BDNF) mRNA expression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2010 journal article
TGF-β–Activated Kinase 1 Signaling Maintains Intestinal Integrity by Preventing Accumulation of Reactive Oxygen Species in the Intestinal Epithelium
The Journal of Immunology, 185(8), 4729–4737.
Contributors: R. Kajino-Sakamoto n, E. Omori n, P. Nighot n, A. Blikslager n , K. Matsumoto * & n
MeSH headings : Animals; Blotting, Western; Epithelium / enzymology; Epithelium / immunology; Gene Expression; Gene Expression Regulation / immunology; Immunity, Mucosal / physiology; Immunohistochemistry; Intestinal Mucosa / enzymology; Intestinal Mucosa / immunology; MAP Kinase Kinase Kinases / immunology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-E2-Related Factor 2 / immunology; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / immunology; Reactive Oxygen Species / immunology; Reactive Oxygen Species / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction
TL;DR:
It is reported that TGF-β–activated kinase 1 (TAK1) is a key regulator of ROS in the intestinal epithelium and regulates ROS through transcription factor NF-E2–related factor 2, which is important for intestinal epithelial integrity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 6, 2018
2009 journal article
Intestinal Epithelial-Derived TAK1 Signaling Is Essential for Cytoprotection against Chemical-Induced Colitis
PLOS ONE, 4(2).
Contributors: J. Kim n, R. Kajino-Sakamoto n, E. Omori n, C. Jobin * & n
MeSH headings : Animals; Apoptosis; Cell Proliferation; Colitis / chemically induced; Colitis / etiology; Cyclooxygenase 2; Dextran Sulfate; Interleukin-6; Intestinal Mucosa / metabolism; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Knockout; Receptors, Tumor Necrosis Factor, Type I / deficiency; Signal Transduction
TL;DR:
It is shown that TAK1 is essential for interleukin 1- and bacterial components-induced expression of cytoprotective factors and cell proliferation, which is pivotal for protecting the intestinal epithelium against injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2009 journal article
TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP
ONCOGENE, 28(23), 2257–2265.
Contributors: S. Morioka*, E. Omori n, T. Kajino *, R. Kajino-Sakamoto n, K. Matsumoto * & n
author keywords: TAK1; TRAIL; reactive oxygen species; cIAP; apoptosis
MeSH headings : Animals; Apoptosis / drug effects; Caspase 3 / metabolism; Cell Line; Cell Line, Tumor; Cell Survival / drug effects; Electrophoretic Mobility Shift Assay; Flow Cytometry; HeLa Cells; Humans; Immunoblotting; Inhibitor of Apoptosis Proteins / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Microscopy, Fluorescence; NF-kappa B / metabolism; RNA, Small Interfering / genetics; Reactive Oxygen Species / metabolism; Recombinant Proteins / pharmacology; TNF-Related Apoptosis-Inducing Ligand / genetics; TNF-Related Apoptosis-Inducing Ligand / pharmacology; Transfection
TL;DR:
It is reported that deletion of TAK1 kinase greatly increased activation of caspase-3 and cell death after TRAIL stimulation in keratinocytes, fibroblasts and cancer cells, and inhibition of Tak1 can be an effective approach to increase TRAIL sensitivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2009 journal article
Transforming Growth Factor beta-activated Kinase 1 (TAK1) Kinase Adaptor, TAK1-binding Protein 2, Plays Dual Roles in TAK1 Signaling by Recruiting Both an Activator and an Inhibitor of TAK1 Kinase in Tumor Necrosis Factor Signaling Pathway
JOURNAL OF BIOLOGICAL CHEMISTRY, 285(4), 2333–2339.
Contributors: P. Broglie n, K. Matsumoto *, S. Akira *, D. Brautigan * & n
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Cell Line, Transformed; Dermis / cytology; Fibroblasts / cytology; Fibroblasts / enzymology; Gene Deletion; JNK Mitogen-Activated Protein Kinases / metabolism; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System / drug effects; MAP Kinase Signaling System / physiology; Mice; NF-kappa B / metabolism; Phosphoprotein Phosphatases / metabolism; Phosphorylation / physiology; Tumor Necrosis Factor-alpha / metabolism; Tumor Necrosis Factor-alpha / pharmacology; Ubiquitin / metabolism; Ubiquitination / physiology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2008 journal article
203 TAK1 Is Essential for Intestinal Epithelial Cell Survival and Regulates Intestinal Integrity
Gastroenterology, 134(4), A-35-A-36.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2008 journal article
Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis
JOURNAL OF IMMUNOLOGY, 181(2), 1143–1152.
Contributors: R. Kajino-Sakamoto n, M. Inagaki n, E. Lippert*, S. Akira *, S. Robine *, K. Matsumoto *, C. Jobin *, n
MeSH headings : Animals; Apoptosis; Colitis / immunology; Colitis / metabolism; Enterocytes / cytology; Enterocytes / immunology; Enterocytes / metabolism; Ileitis / immunology; Ileitis / metabolism; Intestinal Mucosa / immunology; Intestinal Mucosa / metabolism; MAP Kinase Kinase Kinases / immunology; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Mice, Mutant Strains; Signal Transduction; Tumor Necrosis Factor-alpha / immunology; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
Enterocyte apoptosis and intestinal inflammation were strongly attenuated when enterocyte-specific constitutive TAK1-deleted mice were crossed to TNF receptor 1−/− mice, and it is proposed that aberration in Tak1 signaling might disrupt intestinal homeostasis and favor the development of inflammatory disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2008 journal article
Generation of a conditional mutant allele for Tab1 in mouse
GENESIS, 46(8), 431–439.
Contributors: M. Inagaki n, Y. Komatsu *, G. Scott*, G. Yamada *, M. Ray*, n , Y. Mishina *
author keywords: conditional gene knockout; MAP kinase; BMP; Tab1; TGF-beta
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Animals; Exons; Gene Targeting; Integrases / metabolism; Mice; Mutation
TL;DR:
It is demonstrated that Cre‐mediated recombination using Sox2‐Cre, a Cre line expressed in the epiblast during early embryogenesis, results in deletion of the gene and protein and homozygous Cre‐recombined null embryos display an identical phenotype to conventional null embryos.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2008 journal article
TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappa B
JOURNAL OF BIOLOGICAL CHEMISTRY, 283(28), 19245–19254.
Contributors: T. Prickett *, n , P. Broglie n, T. Muratore-Schroeder*, J. Shabanowitz *, D. Hunt *, D. Brautigan *
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Amino Acid Motifs / genetics; Amino Acid Substitution; Humans; I-kappa B Kinase / genetics; I-kappa B Kinase / metabolism; Interleukin-1beta / metabolism; MAP Kinase Kinase 3 / genetics; MAP Kinase Kinase 3 / metabolism; MAP Kinase Kinase 6 / genetics; MAP Kinase Kinase 6 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mutation, Missense; NF-kappa B / genetics; NF-kappa B / metabolism; Phosphorylation; Protein Binding / genetics; Protein Structure, Tertiary / genetics; Signal Transduction / physiology; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Ubiquitin / genetics; Ubiquitin / metabolism; p38 Mitogen-Activated Protein Kinases / genetics; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
The results show that TAB4 binds TAK1 and polyubiquitin chains to promote specific sites of phosphorylation in TAK 1-TAB1, which activates IKK signaling to NF-κB.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2008 journal article
TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity
JOURNAL OF BIOLOGICAL CHEMISTRY, 283(38), 26161–26168.
Contributors: E. Omori n, S. Morioka n, K. Matsumoto * & n
MeSH headings : Animals; Antioxidants / metabolism; Cytochromes c / metabolism; Gene Expression Regulation; Inflammation; Keratinocytes / cytology; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Transgenic; Models, Biological; NF-kappa B / metabolism; Oxidative Stress; Proto-Oncogene Proteins c-jun / metabolism; Reactive Oxygen Species; Skin / metabolism
TL;DR:
It is shown that, in an in vivo setting, the antioxidant treatment could reduce an inflammatory condition in keratinocyte-specific Tak1 deletion mice and regulate ROS partially through c-Jun, which is important for preventing ROS-induced skin inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2008 journal article
TAK1-binding Protein 1, TAB1, Mediates Osmotic Stress-induced TAK1 Activation but Is Dispensable for TAK1-mediated Cytokine Signaling
JOURNAL OF BIOLOGICAL CHEMISTRY, 283(48), 33080–33086.
Contributors: M. Inagaki n, E. Omori n, J. Kim n, Y. Komatsu *, G. Scott*, M. Ray*, G. Yamada *, K. Matsumoto *, Y. Mishina *, n
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; Cell Line; Cytokines / metabolism; Embryo, Mammalian / cytology; Embryo, Mammalian / metabolism; Enzyme Activation / physiology; Fibroblasts / cytology; Fibroblasts / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Osmotic Pressure / physiology; Protein Structure, Tertiary / physiology; Signal Transduction / physiology
TL;DR:
It is found that TAK1 is spontaneously activated when the concentration is increased and that it is totally dependent on TAB1, and that the C-terminal 68 amino acids of TAB 1 were sufficient to mediate osmotic stress-induced TAK 1 activation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2007 book
Mitochondrial Dysfunction
In Molecular and Biochemical Toxicology, Fourth Edition (pp. 319–332).
Source: ORCID
Added: September 1, 2024
2007 journal article
Osmotic stress blocks NF-kappa B-dependent in inflammatory responses by inhibiting ubiquitination of I kappa B
FEBS LETTERS, 581(29), 5549–5554.
Contributors: W. HuangFu n, K. Matsumoto * & n
author keywords: NF-kappa B; cytokine; osmotic stress; inflammation
MeSH headings : Animals; Cells, Cultured; Humans; I-kappa B Kinase / metabolism; I-kappa B Proteins / antagonists & inhibitors; I-kappa B Proteins / metabolism; Inflammation / metabolism; Interleukin-1 / antagonists & inhibitors; Interleukin-1 / metabolism; Mice; Mice, Inbred C57BL; NF-KappaB Inhibitor alpha; NF-kappa B / antagonists & inhibitors; NF-kappa B / metabolism; Osmotic Pressure; Signal Transduction; Ubiquitination / physiology
TL;DR:
Osmotic stress‐mediated modification of the NF‐κB pathway, a central signaling pathway in inflammation, is investigated and blockage of IκBα ubiquitination is likely to be a major mechanism for inhibition of inflammation by hypertonic conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2007 journal article
TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation
JOURNAL OF BIOLOGICAL CHEMISTRY, 282(13), 9475–9481.
Contributors: T. Kajino *, E. Omori n, S. Ishii, K. Matsumoto * & n
MeSH headings : Cell Line, Transformed; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins / metabolism; MAP Kinase Kinase Kinases / physiology; Phosphorylation; Proto-Oncogene Proteins / metabolism; Signal Transduction / physiology; Transforming Growth Factor beta / physiology
TL;DR:
The data suggest that TAK1 modulates TGF-β-dependent cellular responses by targeting SnoN for degradation, and this phosphorylation regulated the stability of SnoN.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2007 journal article
TAK1 is a central mediator of NOD2 signaling in epidermal cells
JOURNAL OF BIOLOGICAL CHEMISTRY, 283(1), 137–144.
Contributors: J. Kim n, E. Omori n, K. Matsumoto *, G. Núñez * & n
MeSH headings : Acetylmuramyl-Alanyl-Isoglutamine / pharmacology; Animals; Cell Line; Cell Line, Tumor; Cells, Cultured; Chemokines, CXC / genetics; Chemokines, CXC / metabolism; Electrophoretic Mobility Shift Assay; Humans; Immunity, Innate / drug effects; Immunoblotting; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases / genetics; JNK Mitogen-Activated Protein Kinases / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Mutant Strains; Models, Biological; NF-kappa B / genetics; NF-kappa B / metabolism; Nod2 Signaling Adaptor Protein / genetics; Nod2 Signaling Adaptor Protein / metabolism; Receptor-Interacting Protein Serine-Threonine Kinase 2 / genetics; Receptor-Interacting Protein Serine-Threonine Kinase 2 / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction / drug effects; Transfection; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
It is shown that transforming growth factor β-activated kinase 1 (TAK1) is an essential intermediate of NOD2 signaling and its ablation may impair the skin barrier function leading to inflammation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2006 journal article
Osmotic Stress Activates the TAK1-JNK Pathway While Blocking TAK1-mediated NF-κB Activation
Journal of Biological Chemistry, 281(39), 28802–28810.
Contributors: W. HuangFu n, E. Omori n, S. Akira *, K. Matsumoto * & n
MeSH headings : Animals; Cell Line; Enzyme Activation; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / metabolism; Mice; NF-kappa B / metabolism; Osmosis; Protein Binding; Protein Kinases / chemistry; Protein Kinases / physiology; Protein Serine-Threonine Kinases / physiology; RNA, Small Interfering / metabolism
TL;DR:
It is found that TAK1 is essential for osmotic stress-induced activation of JNK but is not an exclusive mediator of p38 activation, and TAO2 (thousand-and-one amino acid kinase 2) associates with Tak1 and can inhibit TAK 1-mediated activation of NF-κB but not of J NK.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Crossref, NC State University Libraries, ORCID
Added: August 28, 2020
2006 journal article
Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappa B activation - TAO2 regulates TAK1 pathways
Journal of Biological Chemistry, 281(39), 28802–28810.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2006 journal article
Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway
JOURNAL OF BIOLOGICAL CHEMISTRY, 281(52), 39891–39896.
Contributors: T. Kajino *, H. Ren *, S. Iemura *, T. Natsume *, B. Stefansson *, D. Brautigan *, K. Matsumoto *, n
MeSH headings : Cells, Cultured; Down-Regulation / drug effects; Down-Regulation / physiology; Enzyme Activation / physiology; Enzyme Inhibitors / pharmacology; Humans; Interleukin-1 / physiology; Isoenzymes / antagonists & inhibitors; Isoenzymes / biosynthesis; Isoenzymes / physiology; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Kinase Kinases / physiology; Phosphoprotein Phosphatases / antagonists & inhibitors; Phosphoprotein Phosphatases / biosynthesis; Phosphoprotein Phosphatases / physiology; Phosphorylation / drug effects; Signal Transduction / drug effects; Signal Transduction / physiology; Up-Regulation / drug effects
TL;DR:
It is found that toxin inhibition of type 2A protein phosphatases greatly enhances interleukin 1 (IL-1)-dependent phosphorylation of Thr-187 in the TAK1 activation loop as well as the catalytic activity of Tak1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2006 journal article
TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappa B
JOURNAL OF BIOLOGICAL CHEMISTRY, 281(12), 7863–7872.
Contributors: N. Uemura n, T. Kajino *, H. Sanjo *, S. Sato *, S. Akira *, K. Matsumoto *, n
MeSH headings : Animals; Cell Line; Cytoplasm / metabolism; Enzyme Activation; Enzyme Inhibitors / pharmacology; Fibroblasts / metabolism; Gene Deletion; Herpesvirus 4, Human / metabolism; Humans; Immunoblotting; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Transgenic; Models, Biological; Mutation; NF-kappa B / metabolism; Plasmids / metabolism; Signal Transduction; TNF Receptor-Associated Factor 6 / metabolism; Transfection; Viral Matrix Proteins / metabolism
TL;DR:
Results suggest that an LMP1-associated complex containing TRAF6, TAB2, and TAK1 plays an essential role in the activation of JNK, however, TAK 1 is not an exclusive intermediate for NF-κB activation in L MP1 signaling.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2006 journal article
TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis
JOURNAL OF BIOLOGICAL CHEMISTRY, 281(28), 19610–19617.
Contributors: E. Omori n, K. Matsumoto *, H. Sanjo *, S. Sato *, S. Akira *, R. Smart n , n
MeSH headings : Animals; Apoptosis; Cytokines / metabolism; Epidermis / metabolism; Gene Deletion; Homeostasis; Inflammation; Keratinocytes / cytology; Keratinocytes / metabolism; MAP Kinase Kinase 4 / metabolism; MAP Kinase Kinase Kinases / physiology; Mice; Mice, Inbred C57BL; NF-kappa B / metabolism; Skin / pathology
TL;DR:
It is demonstrated that TAK1 is the major regulator of skin inflammation as well as keratinocyte death in vivo and is a master regulator of TNF signaling in skin and regulates skin inflammation and keratinocytes death.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2006 journal article
TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells
INTERNATIONAL IMMUNOLOGY, 18(10), 1405–1411.
Contributors: S. Sato *, H. Sanjo, T. Tsujimura, , M. Yamamoto, T. Kawai, O. Takeuchi, S. Akira
author keywords: IBD; regulatory T cells; signal transduction; TCR
MeSH headings : Aging / genetics; Aging / immunology; Aging / pathology; Animals; B-Lymphocytes / immunology; B-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; Colitis / genetics; Colitis / immunology; Colitis / pathology; Colitis / prevention & control; Humans; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / immunology; MAP Kinase Signaling System / genetics; MAP Kinase Signaling System / immunology; Mice; Mice, Knockout; T-Lymphocytes, Regulatory / immunology; T-Lymphocytes, Regulatory / pathology; Thymus Gland / immunology; Thymus Gland / pathology
TL;DR:
The results show that TAK1, by controlling the generation of central Treg cells, is important for preventing spontaneously developing colitis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2006 journal article
Tab1
AfCS-Nature Molecule Pages, 3.
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2006 journal article
Tak1
AfCS-Nature Molecule Pages, 1.
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2005 journal article
AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart
CIRCULATION RESEARCH, 97(9), 872–879.
Contributors: J. Li n, E. Miller n, n , R. Russell III & L. Young n
author keywords: ischemia; AMP-activated protein kinase; p38 MAPK mitogen-activated protein kinase; transforming growth factor-beta-activated protein kinase 1-binding protein 1; glucose transport
MeSH headings : AMP-Activated Protein Kinases; Aminoimidazole Carboxamide / analogs & derivatives; Aminoimidazole Carboxamide / pharmacology; Animals; Anisomycin / pharmacology; Cell Hypoxia; Enzyme Activation; Glucose / metabolism; Glucose Transporter Type 4 / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; MAP Kinase Kinase 3 / physiology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multienzyme Complexes / physiology; Myocardial Ischemia / enzymology; Protein Serine-Threonine Kinases / physiology; Protein Transport; Rats; Rats, Sprague-Dawley; Ribonucleotides / pharmacology; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
AMP-activated protein kinase has an important role in promoting p38 MAPK activation in the ischemic heart by inducing p38MAPK autophosphorylation through interaction with the scaffold protein TAB1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2005 journal article
Essential function for the kinase TAK1 in innate and adaptive immune responses
NATURE IMMUNOLOGY, 6(11), 1087–1095.
Contributors: S. Sato *, H. Sanjo *, K. Takeda *, n , M. Yamamoto *, T. Kawai *, K. Matsumoto *, O. Takeuchi *, S. Akira *
MeSH headings : Animals; B-Lymphocytes / drug effects; B-Lymphocytes / enzymology; B-Lymphocytes / immunology; CD40 Antigens / pharmacology; Embryo, Mammalian / cytology; Fibroblasts / drug effects; Fibroblasts / enzymology; Gene Deletion; Immunity, Innate; Interleukin-17 / pharmacology; Lymphopoiesis; MAP Kinase Kinase Kinases / deficiency; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / physiology; Membrane Glycoproteins / immunology; Mice; Mice, Mutant Strains; NF-kappa B / pharmacology; Receptors, Antigen, B-Cell / agonists; Receptors, Antigen, B-Cell / immunology; Receptors, Cell Surface / immunology; Toll-Like Receptors; Tumor Necrosis Factor-alpha / pharmacology
TL;DR:
It is shown that TAK1 is key in the cellular response to a variety of stimuli and was indispensable for cellular responses to Toll-like receptor ligands, CD40 and B cell receptor crosslinking.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2005 journal article
TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway
GENES TO CELLS, 10(5), 447–454.
Contributors: S. Kishida n, H. Sanjo *, S. Akira *, K. Matsumoto * & n
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / metabolism; Animals; I-kappa B Kinase; Interleukin-1 / metabolism; Mice; Mutation; NF-kappa B / metabolism; Protein Serine-Threonine Kinases / metabolism; Protein Structure, Tertiary; Signal Transduction / physiology; TNF Receptor-Associated Factor 6 / metabolism; Ubiquitin / metabolism
TL;DR:
TAK1‐binding protein 2 (TAB2) functions to facilitate TRAF6 ubiquitination and thereby mediates IL‐1‐induced cellular events, and a conserved ubiquitin binding domain in TAB2, the CUE domain, is important for this function.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2005 journal article
Transforming growth factor beta-activated kinase 1 is a key mediator of ovine follicle-stimulating hormone beta-subunit expression
ENDOCRINOLOGY, 146(11), 4814–4824.
MeSH headings : Activins / pharmacology; Animals; Cell Line; Enzyme Activation / physiology; Follicle Stimulating Hormone, beta Subunit / antagonists & inhibitors; Follicle Stimulating Hormone, beta Subunit / biosynthesis; Follicle Stimulating Hormone, beta Subunit / genetics; Follicle Stimulating Hormone, beta Subunit / metabolism; Humans; Inhibin-beta Subunits / pharmacology; Kinetics; Lactones / pharmacology; Luciferases / genetics; MAP Kinase Kinase Kinases / metabolism; Phosphorylation; Recombinant Fusion Proteins / biosynthesis; Recombinant Proteins / pharmacology; Resorcinols / pharmacology; Sheep; Transfection; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
This study used 4.7 kb of the ovine FSHβ-promoter linked to luciferase (oFSHβLuc) plus a well-characterized activin-responsive construct, p3TPLuc, to investigate the hypothesis that Smad3, TGFβ-activated kinase 1 (TAK1), or both cause activationin-mediated induction of FSH.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2004 journal article
Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells
JOURNAL OF BIOLOGICAL CHEMISTRY, 279(35), 36616–36620.
Contributors: S. Akiyama *, T. Yonezawa *, T. Kudo *, M. Li*, H. Wang*, M. Ito *, K. Yoshioka *, n
MeSH headings : Animals; Blotting, Northern; Carcinoma, Embryonal / metabolism; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Nucleus / metabolism; Enzyme Activation; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Developmental; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 4; MAP Kinase Kinase Kinases / metabolism; Mice; Microscopy, Confocal; Mitogen-Activated Protein Kinases / metabolism; Neurons / metabolism; Phosphoprotein Phosphatases / metabolism; Precipitin Tests; Protein Phosphatase 2C; Signal Transduction; Transfection; Tretinoin / metabolism; Tubulin / metabolism
TL;DR:
It is demonstrated that activities of MAPK kinase 4 and TAK1, one of the upstream kinases of MKK4, were enhanced in the neurally differentiating cells and suggest that two distinct TAK 1-MKK4-JNK signaling pathways are independently activated at the different intracellular locations and may participate in the regulation of the neural differentiation of P19 cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2004 journal article
Involvement of ASK1 in Ca 2+ ‐induced p38 MAP kinase activation
EMBO Reports, 5(2), 161–166.
Contributors: K. Takeda *, A. Matsuzawa *, H. Nishitoh *, K. Tobiume *, S. Kishida*, * , K. Matsumoto *, H. Ichijo *
MeSH headings : Animals; Calcium / metabolism; Calcium / pharmacology; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Cells, Cultured; Fibroblasts / drug effects; Fibroblasts / metabolism; Glutathione Transferase / analysis; MAP Kinase Kinase Kinase 5 / metabolism; MAP Kinase Kinase Kinase 5 / physiology; MAP Kinase Signaling System / physiology; Marine Toxins / pharmacology; Mice; Mice, Inbred C57BL; Oxocins / pharmacology; Phosphorylation; Potassium Channels, Calcium-Activated / metabolism; RNA, Small Interfering / pharmacology; Synaptosomes / drug effects; Synaptosomes / metabolism; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
It is shown that Ca2+ signalling regulates the ASK1–p38 MAP kinase cascade, which is a critical intermediate of Ca2- signalling between CaMKII and p38 MAP Kinase.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries, ORCID
Added: January 5, 2021
2004 journal article
Wnt-1 signal induces, phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK
Genes and Development, 18(7), 816–829.
Contributors: C. Kanei-Ishii*, * , J. Tanikawa *, T. Nomura*, T. Ishitani*, S. Kishida*, K. Kokura *, T. Kurahashi*
Source: ORCID
Added: September 1, 2024
2003 journal article
A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 307(2), 332–337.
author keywords: transforming growth factor-beta; TGF-beta activated kinase 1; dominant negative inhibitor; fibrotic marker proteins
MeSH headings : Adaptor Proteins, Signal Transducing; Animals; Biomarkers; Carrier Proteins / metabolism; Cell Line; Collagen Type I / metabolism; Collagen Type IV / metabolism; Extracellular Matrix / metabolism; Fibronectins / metabolism; Fibrosis / metabolism; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Plasminogen Activator Inhibitor 1 / metabolism; Protein Binding; Signal Transduction / physiology; Transforming Growth Factor beta / metabolism; Two-Hybrid System Techniques
TL;DR:
A minimal portion of TAK1 lacking kinase activity that binds to TAB1 was designed as a Tak1 dominant negative inhibitor (TAK1-DN) that decreased the ECM protein production, indicating that TAK 1-DN retains the ability to intercept the TGF-beta signaling effectively.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2003 journal article
A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase
JOURNAL OF BIOLOGICAL CHEMISTRY, 278(20), 18485–18490.
Contributors: n , T. Kajino *, K. Ono, T. Ohtomo, M. Matsumoto, M. Shiina, M. Mihara, M. Tsuchiya, K. Matsumoto *
MeSH headings : Animals; Anti-Inflammatory Agents / chemistry; Anti-Inflammatory Agents / pharmacology; Cell Line; Cells, Cultured; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Activation; Female; Genes, Reporter; Genetic Vectors; Humans; Immunoblotting; Inflammation; Inhibitory Concentration 50; Interleukin-1 / metabolism; Isoenzymes / metabolism; Lactones / chemistry; MAP Kinase Kinase Kinases / metabolism; MAP Kinase Signaling System; Membrane Proteins; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases / metabolism; Models, Chemical; Precipitin Tests; Prostaglandin-Endoperoxide Synthases / metabolism; Protein Binding; Signal Transduction; Time Factors; Transfection; Zearalenone / analogs & derivatives; Zearalenone / chemistry; Zearalenone / pharmacology; p38 Mitogen-Activated Protein Kinases
TL;DR:
5Z-7-oxozeaenol blocks proinflammatory signaling by selectively inhibiting TAK1 MAPKKK, resulting in inhibition of cyclooxgenase-2 production in cell culture and in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2003 journal article
Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/β-catenin signaling
Molecular and Cellular Biology, 23(4), 1379–1389.
Source: ORCID
Added: September 1, 2024
2003 journal article
Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2C epsilon)
JOURNAL OF BIOLOGICAL CHEMISTRY, 278(14), 12013–12021.
Contributors: M. Li*, K. Katsura*, H. Nomiyama *, K. Komaki*, n , K. Matsumoto *, T. Kobayashi*, S. Tamura*
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases / metabolism; Escherichia coli; Gene Expression Regulation, Enzymologic; Genes, Reporter; In Vitro Techniques; Interleukin-1 / pharmacology; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase 3; MAP Kinase Kinase 4; MAP Kinase Kinase 6; MAP Kinase Kinase Kinases / metabolism; Mice; Mitogen-Activated Protein Kinase Kinases / metabolism; Mitogen-Activated Protein Kinases / metabolism; Molecular Sequence Data; Phosphoprotein Phosphatases / genetics; Phosphoprotein Phosphatases / metabolism; Phosphorylation; Point Mutation; Protein Phosphatase 2C; Protein-Tyrosine Kinases / metabolism; Signal Transduction / drug effects; Signal Transduction / physiology; Transcription Factor AP-1 / genetics; p38 Mitogen-Activated Protein Kinases
TL;DR:
Results suggest that, in the absence of IL-1-induced signal, PP2Cε contributes to keeping the TAK1 signaling pathway in an inactive state by associating with and dephosphorylating TAK 1.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2003 journal article
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling
EMBO Journal, 22(23), 6277–6288.
Contributors: T. Ishitani*, G. Takaesu *, * , H. Shibuya *, R. Gaynor* & K. Matsumoto *
Source: ORCID
Added: September 1, 2024
2003 journal article
TAB2 is essential for prevention of apoptosis in fetal liver but not for interleukin-1 signaling
Molecular and Cellular Biology, 23(4), 1231–1238.
Contributors: H. Sanjo *, K. Takeda *, T. Tsujimura *, * , K. Matsumoto * & S. Akira *
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: September 1, 2024
2003 journal article
TAK1 is critical for I kappa B kinase-mediated activation of the NF-kappa B pathway
JOURNAL OF MOLECULAR BIOLOGY, 326(1), 105–115.
Contributors: G. Takaesu *, R. Surabhi*, K. Park*, n , K. Matsumoto * & R. Gaynor*
author keywords: NF-kappa B; I kappa B kinase; TAK1; signal transduction; RNA interference
MeSH headings : Enzyme Activation / drug effects; Gene Expression; HeLa Cells; Humans; I-kappa B Kinase; Interleukin-1 / pharmacology; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; NF-kappa B / metabolism; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Proteins / genetics; Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; Signal Transduction / drug effects; TNF Receptor-Associated Factor 2; Transfection; Tumor Necrosis Factor-alpha / pharmacology
TL;DR:
Small interfering RNAs directed against IKKα, IKKβ and the upstream regulatory kinase TAK1 were utilized in order to better define their roles in cytokine-induced activation of the NF-κB pathway.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2002 journal article
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol
Molecular and Cellular Biology, 22(20), 7158–7167.
Contributors: Z. Jiang *, * , Y. Qian *, K. Matsumoto * & X. Li *
Source: ORCID
Added: September 1, 2024
2002 journal article
Receptor activator of NF-κB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6
Molecular and Cellular Biology, 22(4), 992–1000.
Contributors: J. Mizukami, G. Takaesu *, H. Akatsuka*, H. Sakurai *, * , K. Matsumoto *, N. Sakurai *
Source: ORCID
Added: September 1, 2024
2002 journal article
SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans
EMBO Reports, 3(1), 56–62.
Contributors: M. Tanaka-Hino*, A. Sagasti *, N. Hisamoto *, M. Kawasaki *, S. Nakano *, * , C. Bargmann *, K. Matsumoto *
Source: ORCID
Added: September 1, 2024
2002 journal article
Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis
MECHANISMS OF DEVELOPMENT, 119(2), 239–249.
Contributors: Y. Komatsu *, H. Shibuya *, N. Takeda *, n , T. Yasui*, K. Miyado *, T. Sekimoto*, N. Ueno *, K. Matsumoto *, G. Yamada *
author keywords: bone morphogenetic protein; mitogen-activated protein kinase; mouse; signal transduction; TGF-beta activated kinase-1 binding protein-1; TGF-beta activated kinase-1; transforming growth factor-beta
MeSH headings : Adaptor Proteins, Signal Transducing; Alleles; Amino Acid Sequence; Animals; Blotting, Western; Cell Differentiation; Cell Division; Cloning, Molecular; Genotype; HIV Envelope Protein gp120 / genetics; HIV Envelope Protein gp120 / physiology; Heart / embryology; Homozygote; Humans; Immunoblotting; In Situ Hybridization; Luciferases / metabolism; Lung / embryology; MAP Kinase Kinase Kinases / metabolism; Mice; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Oligonucleotides, Antisense / pharmacology; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / physiology; Recombination, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Tissue Distribution; Transfection; Transforming Growth Factor beta / metabolism
TL;DR:
A possibility that TAB1 plays an important role in mammalian embryogenesis and is required for TAK1 activation in TGF-beta signaling is indicated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2002 journal article
The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca<sup>2+</sup> pathway to antagonize Wnt/β-catenin signaling
Molecular and Cellular Biology, 23(1), 131–139.
Contributors: T. Ishitani*, S. Kishida*, J. Hyodo-Miura*, N. Ueno *, J. Yasuda *, M. Waterman *, H. Shibuya *, R. Moon *, * , K. Matsumoto*
Source: ORCID
Added: September 1, 2024
2001 journal article
A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK
EMBO Journal, 20(19), 5421–5430.
Contributors: H. Inoue *, M. Tateno*, K. Fujimura-Kamada *, G. Takaesu *, T. Adachi-Yamada *, * , K. Irie *, Y. Nishida*, K. Matsumoto *
Source: ORCID
Added: September 1, 2024
2001 journal article
An Evolutionarily Conserved Motif in the TAB1 C-terminal Region is Necessary for Interaction with and Activation of TAK1 MAPKKK
Journal of Biological Chemistry, 276(26), 24396–24400.
Contributors: K. Ono, T. Ohtomo, S. Sato, Y. Sugamata, M. Suzuki*, N. Hisamoto *, * , M. Tsuchiya, K. Matsumoto *
Source: ORCID
Added: September 1, 2024
2001 journal article
IRAK-mediated Translocation of TRAF6 and TAB2 in the Interleukin-1-induced Activation of NFκB
Journal of Biological Chemistry, 276(45), 41661–41667.
Contributors: Y. Qian *, M. Commane*, * , K. Matsumoto * & X. Li *
Source: ORCID
Added: September 1, 2024
2001 journal article
Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway
Molecular and Cellular Biology, 21(7), 2475–2484.
Contributors: G. Takaesu *, * , S. Kishida*, X. Li, G. Stark * & K. Matsumoto *
Source: ORCID
Added: September 1, 2024
2001 journal article
Regulation of the TAK1 Signaling Pathway by Protein Phosphatase 2C
Journal of Biological Chemistry, 276(8), 5753–5759.
Contributors: M. Hanada*, * , K. Komaki*, M. Ohnishi, K. Katsura, R. Kanamaru*, K. Matsumoto *, S. Tamura
Source: ORCID
Added: September 1, 2024
2001 journal article
The MAPK Kinase Kinase TAK1 Plays a Central Role in Coupling the Interleukin-1 Receptor to Both Transcriptional and RNA-targeted Mechanisms of Gene Regulation
Journal of Biological Chemistry, 276(5), 3508–3516.
Contributors: H. Holtmann*, J. Enninga *, S. Kälble*, A. Thiefes*, A. Dörrie*, M. Broemer *, R. Winzen*, A. Wilhelm*
Source: ORCID
Added: September 1, 2024
2000 journal article
ASK1 inhibits interleukin-1-induced NF-κB activity through disruption of TRAF6-TAK1 interaction
Journal of Biological Chemistry, 275(42), 32747–32752. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034693222&partnerID=MN8TOARS
Source: ORCID
Added: September 1, 2024
2000 journal article
Molecular cloning of MINK, a novel member of mammalian GCK family kinases, which is up-regulated during postnatal mouse cerebral development
FEBS Letters, 469(1), 19–23.
Contributors: I. Dan, N. Watanabe*, T. Kobayashi, K. Yamashita-Suzuki, Y. Fukagaya, E. Kajikawa, W. Kimura*, T. Nakashima *
Source: ORCID
Added: September 1, 2024
2000 journal article
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
Molecular Cell, 5(4), 649–658. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033634977&partnerID=MN8TOARS
Source: ORCID
Added: September 1, 2024
2000 journal article
TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop
Journal of Biological Chemistry, 275(10), 7359–7364.
Contributors: K. Kishimoto*, K. Matsumoto * & *
Source: ORCID
Added: September 1, 2024
1999 journal article
A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons
EMBO Journal, 18(13), 3604–3615.
Contributors: M. Kawasaki *, N. Hisamoto *, Y. Lino, M. Yamamoto *, * & K. Matsumoto *
Source: ORCID
Added: September 1, 2024
1999 journal article
Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-β-induced gene expression
Journal of Biological Chemistry, 274(38), 27161–27167.
Contributors: H. Hanafusa *, * , N. Masuyama*, M. Nishita *, J. Fujisawa *, H. Shibuya *, K. Matsumoto *, E. Nishida *
Source: ORCID
Added: September 1, 2024
1999 journal article
Map kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans
Nature, 399(6738), 793–797.
Contributors: M. Meneghini *, T. Ishitani*, J. Carter*, N. Hisamoto *, * , C. Thorpe *, D. Hamill *, K. Matsumoto *, B. Bowerman *
Source: ORCID
Added: September 1, 2024
1999 journal article
The TAK1-NLK-MAPK-related pathway antagonizes signalling between β- catenin and transcription factor TCF
Nature, 399(6738), 798–802.
Contributors: T. Ishitani*, * , S. Nagai*, M. Nishita *, M. Meneghini *, N. Barker *, M. Waterman *, B. Bowerman *
Source: ORCID
Added: September 1, 2024
1999 journal article
The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
Nature, 398(6724), 252–256.
Contributors: * , K. Kishimoto*, A. Hiyama*, J. Inoue *, Z. Cao & K. Matsumoto *
Source: ORCID
Added: September 1, 2024
1999 journal article
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway
EMBO Journal, 18(1), 179–187.
Contributors: K. Yamaguchi *, S. Nagai, , M. Nishita, K. Tamai, K. Irie, N. Ueno, E. Nishida, H. Shibuya, K. Matsumoto
Source: ORCID
Added: September 1, 2024
1997 journal article
Functional analyses of mammalian protein kinase C isozymes in budding yeast and mammalian fibroblasts
Genes to Cells, 2(10), 601–614. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031240976&partnerID=MN8TOARS
Source: ORCID
Added: September 1, 2024
1997 journal article
TGF-beta signaling
Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme, 42(10 Suppl), 1517–1524. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031183774&partnerID=MN8TOARS
Source: ORCID
Added: September 1, 2024
1996 journal article
G<inf>1</inf> phase-specific suppression of the Cdk2 activity by ginsenoside Rh<inf>2</inf> in cultured murine cells
Life Sciences, 60(2).
Contributors: T. Ota*, M. Maeda*, S. Odashima*, * & M. Tatsuka *
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: September 1, 2024
1993 journal article
Augmentation by IL-1α of tumor necrosis factor-α cytotoxicity in cells transfected with adenovirus E1A
Journal of Immunology, 150(5), 1897–1907. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027223371&partnerID=MN8TOARS
Source: ORCID
Added: September 1, 2024
1993 journal article
Selective loss of CDC2 and CDK2 induction by tumor necrosis factor-α in senescent human diploid fibroblasts
Experimental Cell Research, 209(2), 175–182. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027146392&partnerID=MN8TOARS
Source: ORCID
Added: September 1, 2024
1993 journal article
Tumor necrosis factor-induced c-myc expression in the absence of mitogenesis is associated with inhibition of adipocyte differentiation
Proceedings of the National Academy of Sciences of the United States of America, 90(20), 9611–9615. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027491022&partnerID=MN8TOARS
Source: ORCID
Added: September 1, 2024
1992 journal article
Cyclin-dependent kinase 2 (cdk2) in the murine cdc2 kinase TS mutant
Somatic Cell and Molecular Genetics, 18(5), 403–408.
Contributors: H. Yasuda*, T. Nakata*, M. Kamijo*, R. Honda*, M. Nakamura*, * , M. Yamashita *, Y. Nagahama*, Y. Ohba*
Source: ORCID
Added: September 1, 2024
1992 journal article
IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc
Cell, 70(1), 57–67.
Contributors: H. Shibuya *, M. Yoneyama *, * , K. Matsumoto * & T. Taniguchi*
Source: ORCID
Added: September 1, 2024
1992 journal article
New human gene encoding a positive modulator of HIV Tat-mediated transactivation
Nature, 357(6380), 700–702. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026689020&partnerID=MN8TOARS
Source: ORCID
Added: September 1, 2024
1991 journal article
Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation
Proceedings of the National Academy of Sciences of the United States of America, 88(20), 9006–9010. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025946804&partnerID=MN8TOARS
Source: ORCID
Added: September 1, 2024
1990 journal article
A temperature-sensitive cell-cycle mutant of mammalian cells, tsJT16, is defective in a function operating soon after growth stimulation
Cell Structure and Function, 15(1), 39–45. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025276307&partnerID=MN8TOARS
Source: ORCID
Added: September 1, 2024
1990 journal article
Nonlethal G<inf>0</inf>-ts mutant tsJT60 becomes lethal at the nonpermissive temperature after transformation: A hint for new cancer chemotherapeutics
Cell Structure and Function, 15(6), 385–391.
Contributors: Y. Tai*, * , K. Furuoku*, N. Ogawa *, S. Ishibashi*, K. Shiroki*, K. Segawa*, N. Tsuchida, M. Shibuya*, T. Ide*
Source: ORCID
Added: September 1, 2024
1988 journal article
A cell cycle G<inf>0</inf>-ts mutant, tsJT60, becomes lethal at the nonpermissive temperature after transformation with adenovirus 12 E1B 19K mutant
Experimental Cell Research, 179(1), 50–57.
Source: ORCID
Added: September 1, 2024
1987 journal article
Bypass of the ts Block of tsJT60, a G<inf>0</inf>-Specific ts Mutant from Rat Fibroblasts, by Fetal Bovine Serum and Epidermal Growth Factor
Cell Structure and Function, 12(5), 421–432.
Contributors: , Y. Nakahara*, C. Ito*, T. Akiyama *, S. Ishibashi* & T. Ide
Source: ORCID
Added: September 1, 2024
1987 journal article
Colchicine activates cell cycle-dependent genes in growth-arrested rat 3Y1 cells
Experimental Cell Research, 173(1), 294–298.
Contributors: M. Miura*, * , Y. Tsuji *, S. Ishibashi* & T. Ide*
Source: ORCID
Added: September 1, 2024
1987 journal article
Entrance of SV40-transformed Cells into g0 Phase as Revealed by a Study Using the g0-specific ts mutant tsjt60
Cancer Research, 47(22), 6028–6032. http://www.scopus.com/inward/record.url?eid=2-s2.0-0023589313&partnerID=MN8TOARS
Source: ORCID
Added: September 1, 2024
1987 journal article
Epidermal growth factor has a unique effect in combination with fetal bovine serum to bypass the ts-block of G<inf>o</inf>-specific ts mutant tsJT60
Experimental Cell Research, 171(1), 86–93.
Contributors: * , Y. Nakahara*, C. Ito*, T. Akiyama *, S. Ishibashi* & T. Ide*
Source: ORCID
Added: September 1, 2024
1987 journal article
Induction of cellular DNA synthesis in G<inf>0</inf>-specific ts mutant, tsJT60, following Infection with SV40 and adenoviruses
Experimental Cell Research, 171(2), 509–512.
Source: ORCID
Added: September 1, 2024
1987 journal article
tsJT60, a cell cycle G0-ts mutant, becomes lethal at non-permissive temperature by transformation with adenovirus 5 when the expression of E1B gene is lacking
Experimental Cell Research, 170(2), 491–498.
Contributors: Y. Goto*, * , K. Tanonaka *, S. Ishibashi*, K. Shiroki* & T. Ide*
Source: ORCID
Added: September 1, 2024
1986 journal article
Defect in prereplicative phase of G0-specific ts mutant, tsJT60
Experimental Cell Research, 165(1), 191–198.
Source: ORCID
Added: September 1, 2024
1986 journal article
Expression of Growth-Regulated Genes in tsJT60 Cells, a Temperature-Sensitive Mutant of the Cell Cycle
Biochemistry, 25(22), 7041–7046.
Source: ORCID
Added: September 1, 2024
1986 journal article
Failure in S6 protein phosphorylation by serum stimulatio of senescent human diploid fibroblasts, TIG-1
Mechanisms of Ageing and Development, 37(1), 27–40.
Source: ORCID
Added: September 1, 2024
1986 journal article
Isolation of ts mutant cells which arrest in G1/G0 phase at the non-permissive temperature in the presence of appropriate growth factors from a Fischer rat cell line, 3Y1
Experimental Cell Research, 165(2), 337–344.
Contributors: K. Tanonaka *, * , S. Ishibashi* & T. Ide*
Source: ORCID
Added: September 1, 2024
1984 journal article
Isolation of a G0-specific ts mutant from a Fischer rat cell line, 3Y1
Experimental Cell Research, 150(1), 60–67.
Contributors: T. Ide*, J. Ninomiya* & S. Ishibashi*
Source: ORCID
Added: September 1, 2024
1984 journal article
Isolation of a G0-specific ts mutant from a Fischer rat cell line, 3Y1.
Exp. Cell Res.
Source: ORCID
Added: September 1, 2024
Employment
Updated: August 30th, 2024 11:58
2013 - present
North Carolina State University Raleigh, NC, US
Professor
Biological Sciences
2008 - 2013
North Carolina State University Raleigh, NC, US
Associate Professor
Environmental and Molecular Toxicology
2002 - 2008
North Carolina State University Raleigh, NC, US
Assistant Professor
Environmental and Molecular Toxicology
Funding History
Funding history based on the linked ORCID record. Updated: November 9th, 2021 11:45
grant
January 1, 2021 - December 31, 2025
TAK1 signaling pathways
National Institute of General Medical Sciences
grant
July 1, 2020 - June 30, 2023
Consequences and significance of TAK1 inhibition in macrophages
National Institute of General Medical Sciences
grant
January 1, 2019
TAK1 as a target of Alzheimer’s disease
Alzheimer's Association
grant
August 1, 2015 - July 31, 2019
TAK1 regulation of metabolism
National Institute of General Medical Sciences
grant
August 1, 2013 - August 1, 2014
Role of TAB1-TAK1 Signaling in Tumor-Associated Macrophage Survival
National Cancer Institute
grant
September 30, 2009 - August 31, 2012
TAK1 regulation of reactive oxygen species and inflammation
National Institute of General Medical Sciences
grant
July 1, 2006 - June 1, 2008
Role of TAK1 in intestinal inflammation and cancer
Crohn's and Colitis Foundation of America
grant
August 1, 2004 - April 30, 2007
ROLE OF TAK1 IN RANKL SIGNALING PATHWAY
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
April 1, 2004 - March 31, 2016
TAK1 signaling network in tissue homeostasis
National Institute of General Medical Sciences
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