Works (47)

2019 journal article

Coordinating Tissue Regeneration Through Transforming Growth Factor-beta Activated Kinase 1 Inactivation and Reactivation

STEM CELLS, 37(6), 766–778.

By: H. Hsieh, S. Agarwal, D. Cholok, S. Loder, K. Kaneko, A. Huber, M. Chung, K. Ranganathan ...

Source: Web Of Science
Added: July 22, 2019

2019 journal article

Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing

JOURNAL OF CELL BIOLOGY, 218(6), 1994–2005.

By: K. Sai, C. Parsons, J. House, S. Kathariou & J. Ninomiya-Tsuji

Source: Web Of Science
Added: June 24, 2019

2018 journal article

Compound mutations in Bmpr1a and Tak1 synergize facial deformities via increased cell death

Genesis, 56(3).

By: X. Liu, S. Hayano, H. Pan, M. Inagaki, J. Ninomiya-Tsuji, H. Sun, Y. Mishina

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Noncanocial cell death program independent of caspase activation cascade and necroptotic modules is elicited by loss of TGF beta-activated kinase 1

Scientific Reports, 7.

By: S. Mihaly, Y. Sakamachi, J. Ninomiya-Tsuji & S. Morioka

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

TAK1 regulates resident macrophages by protecting lysosomal integrity

Cell Death & Disease, 8.

By: Y. Sakamachi, S. Morioka, S. Mihaly, G. Takaesu, J. Foley, M. Fessler, J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus

Journal of Cell Science, 129(9), 1855–1865.

By: K. Sai, S. Morioka, G. Takaesu, N. Muthusamy, H. Ghashghaei, H. Hanafusa, K. Matsumoto, J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

TAK1 regulates Paneth cell integrity partly through blocking necroptosis

Cell Death & Disease, 7.

By: A. Simmons, R. Kajino-Sakamoto & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

TAK1 regulates hepatic lipid homeostasis through SREBP

Oncogene, 35(29), 3829–3838.

By: S. Morioka, K. Sai, E. Omori, Y. Ikeda, K. Matsumoto & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

TAK1 regulates the Nrf2 antioxidant system through modulating p62/SQSTM1

Antioxidants & Redox Signaling, 25(17), 953–964.

By: K. Hashimoto, A. Simmons, R. Kajino-Sakamoto, Y. Tsuji & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Tak1, Smad4 and Trim33 redundantly mediate TGF-beta 3 signaling during palate development

Developmental Biology, 298(2), 231–241.

By: J. Lane, K. Yumoto, M. Azhar, J. Ninomiya-Tsuji, M. Inagaki, Y. Hu, C. Deng, J. Kim, Y. Mishina, V. Kaartinen

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Activated macrophage survival is coordinated by TAK1 binding proteins

PLoS One, 9(4).

By: S. Mihaly, S. Morioka, J. Ninomiya-Tsuji & G. Takaesu

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

TAK1 binding protein 2 is essential for liver protection from stressors

PLoS One, 9(2).

By: Y. Ikeda, S. Morioka, K. Matsumoto & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2014 review

TAK1 control of cell death

Cell Death and Differentiation.

By: S. Mihaly, J. Ninomiya-Tsuji & S. Morioka

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-kappa B activation

Molecular and Cellular Biology, 33(6), 1149–1163.

By: M. Moreno-Garcia, K. Sommer, H. Rincon-Arano, M. Brault, J. Ninomiya-Tsuji, L. Matesic, D. Rawlings

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

TGF-beta-activated kinase 1 (Tak1) mediates agonist-induced smad activation and linker region phosphorylation in embryonic craniofacial neural crest-derived cells

Journal of Biological Chemistry, 288(19), 13467–13480.

By: K. Yumoto, P. Thomas, J. Lane, K. Matsuzaki, M. Inagaki, J. Ninomiya-Tsuji, G. Scott, M. Ray ...

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

TAK1 (MAP3K7) signaling regulates hematopoietic stem cells through TNF-dependent and -independent mechanisms

PLoS One, 7(11).

By: G. Takaesu, M. Inagaki, K. Takubo, Y. Mishina, P. Hess, G. Dean, A. Yoshimura, K. Matsumoto, T. Suda, J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Inhibition of autophagy by TAB2 and TAB3

EMBO Journal, 30(24), 4908–4920.

By: A. Criollo, M. Niso-Santano, S. Malik, M. Michaud, E. Morselli, G. Marino, S. Lachkar, A. Arkhipenko ...

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Non-canonical beta-catenin degradation mediates reactive oxygen species-induced epidermal cell death

Oncogene, 30(30), 3336–3344.

By: E. Omori, K. Matsumoto & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells

Cancer Research, 70(21), 8417–8425.

By: E. Omori, K. Matsumoto, S. Zhu, R. Smart & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271

Molecular Biology of the Cell, 21(16), 2966–2974.

By: K. Sakamoto, B. Huang, K. Iwasaki, K. Hailemariam, J. Ninomiya-Tsuji & Y. Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium

Journal of Immunology, 185(8), 4729–4737.

By: R. Kajino-Sakamoto, E. Omori, P. Nighot, A. Blikslager, K. Matsumoto & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Transforming growth factor beta-activated Kinase 1 (TAK1) kinase adaptor, TAK1-binding protein 2, plays dual roles in TAK1 signaling by recruiting both an activator and an Inhibitor of TAK1 kinase in tumor necrosis factor signaling pathway

Journal of Biological Chemistry, 285(4), 2333–2339.

By: P. Broglie, K. Matsumoto, S. Akira, D. Brautigan & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Intestinal epithelial-derived TAK1 signaling Is essential for cytoprotection against chemical-induced colitis

PLoS One, 4(2).

By: J. Kim, R. Kajino-Sakamoto, E. Omori, C. Jobin & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP

Oncogene, 28(23), 2257–2265.

By: S. Morioka, E. Omori, T. Kajino, R. Kajino-Sakamoto, K. Matsumoto & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis

Journal of Immunology, 181(2), 1143–1152.

By: R. Kajino-Sakamoto, M. Inagaki, E. Lippert, S. Akira, S. Robine, K. Matsumoto, C. Jobin, J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Generation of a conditional mutant allele for Tab1 in mouse

Genesis (New York, N.Y. : 2000), 46(8), 431–439.

By: M. Inagaki, Y. Komatsu, G. Scott, G. Yamada, M. Ray, J. Ninomiya-Tsuji, Y. Mishina

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

TAB4 stimulates TAK1-TAB1 phosphorylation and binds polyubiquitin to direct signaling to NF-kappa B

Journal of Biological Chemistry, 283(28).

By: T. Prickett, J. Ninomiya-Tsuji, P. Broglie, T. Muratore-Schroeder, J. Shabanowitz, D. Hunt, D. Brautigan

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

TAK1 is a central mediator of NOD2 signaling in epidermal cells

Journal of Biological Chemistry, 283(1), 137–144.

By: J. Kim, E. Omori, K. Matsumoto, G. Nunez & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity

Journal of Biological Chemistry, 283(38), 26161–26168.

By: E. Omori, S. Morioka, K. Matsumoto & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but Is dispensable for TAK1-mediated cytokine signaling

Journal of Biological Chemistry, 283(48), 33080–33086.

By: M. Inagaki, E. Omori, J. Kim, Y. Komatsu, G. Scott, M. Ray, G. Yamada, K. Matsumoto, Y. Mishina, J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Osmotic stress blocks NF-kappa B-dependent in inflammatory responses by inhibiting ubiquitination of I kappa B

FEBS Letters, 581(29), 5549–5554.

By: W. HuangFu, K. Matsumoto & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

TAK1 MAPK kinase kinase mediates transforming growth factor-beta signaling by targeting SnoN oncoprotein for degradation

Journal of Biological Chemistry, 282(13), 9475–9481.

By: T. Kajino, E. Omori, S. Ishii, K. Matsumoto & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappa B activation - TAO2 regulates TAK1 pathways

Journal of Biological Chemistry, 281(39), 28802–28810.

By: W. Huangfu, E. Omori, S. Akira, K. Matsumoto & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway

Journal of Biological Chemistry, 281(52), 39891–39896.

By: T. Kajino, H. Ren, S. Iemura, T. Natsume, B. Stefansson, D. Brautigan, K. Matsumoto, J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappa B

Journal of Biological Chemistry, 281(12), 7863–7872.

By: N. Uemura, T. Kajino, H. Sanjo, S. Sato, S. Akira, K. Matsumoto, J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

Journal of Biological Chemistry, 281(28), 19610–19617.

By: E. Omori, K. Matsumoto, H. Sanjo, S. Sato, S. Akira, R. Smart, J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells

International Immunology, 18(10), 1405–1411.

By: S. Sato, H. Sanjo, T. Tsujimura, J. Ninomiya-Tsuji, M. Yamamoto, T. Kawai, O. Takeuchi, S. Akira

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

AMP-activated protein kinase activates p38 mitogen-activated protein kinase by increasing recruitment of p38 MAPK to TAB1 in the ischemic heart

Circulation Research, 97(9), 872–879.

By: J. Li, E. Miller, J. Ninomiya-Tsuji, R. Russell & L. Young

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Essential function for the kinase TAK1 in innate and adaptive immune responses

Nature Immunology, 6(11), 1087–1095.

By: S. Sato, H. Sanjo, K. Takeda, J. Ninomiya-Tsuji, M. Yamamoto, T. Kawai, K. Matsumoto, O. Takeuchi, S. Akira

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

TAK1-binding protein 2 facilitates ubiquitination of TRAF6 and assembly of TRAF6 with IKK in the IL-1 signaling pathway

Genes To Cells, 10(5), 447–454.

By: S. Kishida, H. Sanjo, S. Akira, K. Matsumoto & J. Ninomiya-Tsuji

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Transforming growth factor beta-activated kinase 1 is a key mediator of ovine follicle-stimulating hormone beta-subunit expression

Endocrinology, 146(11), 4814–4824.

By: N. Safwat, J. Ninomiya-Tsuji, A. Gore & W. Miller

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells

Journal of Biological Chemistry, 279(35), 36616–36620.

By: S. Akiyama, T. Yonezawa, T. Kudo, M. Li, H. Wang, M. Ito, K. Yoshioka, J. Ninomiya-Tsuji ...

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

A A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta

Biochemical and Biophysical Research Communications, 307(2), 332–337.

By: K. Ono, T. Ohtomo, J. Ninomiya-Tsuji & M. Tsuchiya

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

A A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase

Journal of Biological Chemistry, 278(20), 18485–18490.

By: J. Ninomiya-Tsuji, T. Kajino, K. Ono, T. Ohtomo, M. Matsumoto, M. Shiina, M. Mihara, M. Tsuchiya, K. Matsumoto

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2C epsilon)

Journal of Biological Chemistry, 278(14), 12013–12021.

By: M. Li, K. Katsura, H. Nomiyama, K. Komaki, J. Ninomiya-Tsuji, K. Matsumoto, T. Kobayashi, S. Tamura

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

TAK1 is critical for I kappa B kinase-mediated activation of the NF-kappa B pathway

Journal of Molecular Biology, 326(1), 105–115.

By: G. Takaesu, R. Surabhi, K. Park, J. Ninomiya-Tsuji, K. Matsumoto & R. Gaynor

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis

Mechanisms of Development, 119(2), 239–249.

By: Y. Komatsu, H. Shibuya, N. Takeda, J. Ninomiya-Tsuji, T. Yasui, K. Miyado, T. Sekimoto, N. Ueno, K. Matsumoto, G. Yamada

Source: NC State University Libraries
Added: August 6, 2018