@misc{frye_cakir_rose_palmer_austin_curtin_arora_2021, title={Mitochondria May Mediate Prenatal Environmental Influences in Autism Spectrum Disorder}, volume={11}, ISSN={["2075-4426"]}, DOI={10.3390/jpm11030218}, abstractNote={We propose that the mitochondrion, an essential cellular organelle, mediates the long-term prenatal environmental effects of disease in autism spectrum disorder (ASD). Many prenatal environmental factors which increase the risk of developing ASD influence mitochondria physiology, including toxicant exposures, immune activation, and nutritional factors. Unique types of mitochondrial dysfunction have been associated with ASD and recent studies have linked prenatal environmental exposures to long-term changes in mitochondrial physiology in children with ASD. A better understanding of the role of the mitochondria in the etiology of ASD can lead to targeted therapeutics and strategies to potentially prevent the development of ASD.}, number={3}, journal={JOURNAL OF PERSONALIZED MEDICINE}, author={Frye, Richard E. and Cakir, Janet and Rose, Shannon and Palmer, Raymond F. and Austin, Christine and Curtin, Paul and Arora, Manish}, year={2021}, month={Mar} }
 @article{frye_cakir_rose_palmer_austin_curtin_2021, title={Physiological mediators of prenatal environmental influences in autism spectrum disorder}, ISSN={["1521-1878"]}, DOI={10.1002/bies.202000307}, abstractNote={Abstract}, journal={BIOESSAYS}, author={Frye, Richard E. and Cakir, Janet and Rose, Shannon and Palmer, Raymond F. and Austin, Christine and Curtin, Paul}, year={2021}, month={Jul} }
 @article{frye_cakir_rose_delhey_bennuri_tippett_melnyk_james_palmer_austin_et al._2021, title={Prenatal air pollution influences neurodevelopment and behavior in autism spectrum disorder by modulating mitochondrial physiology}, volume={26}, ISSN={["1476-5578"]}, DOI={10.1038/s41380-020-00885-2}, abstractNote={Abstract}, number={5}, journal={MOLECULAR PSYCHIATRY}, author={Frye, Richard E. and Cakir, Janet and Rose, Shannon and Delhey, Leanna and Bennuri, Sirish C. and Tippett, Marie and Melnyk, Stepan and James, S. Jill and Palmer, Raymond F. and Austin, Christine and et al.}, year={2021}, month={May}, pages={1561–1577} }
 @article{frye_cakir_rose_delhey_bennuri_tippett_palmer_austin_curtin_arora_2020, title={Early life metal exposure dysregulates cellular bioenergetics in children with regressive autism spectrum disorder}, volume={10}, ISSN={["2158-3188"]}, DOI={10.1038/s41398-020-00905-3}, abstractNote={Abstract}, number={1}, journal={TRANSLATIONAL PSYCHIATRY}, author={Frye, Richard E. and Cakir, Janet and Rose, Shannon and Delhey, Leanna and Bennuri, Sirish C. and Tippett, Marie and Palmer, Raymond F. and Austin, Christine and Curtin, Paul and Arora, Manish}, year={2020}, month={Jul} }
 @article{cakir_frye_walker_2020, title={The lifetime social cost of autism: 1990-2029}, volume={72}, ISSN={["1878-0237"]}, DOI={10.1016/j.rasd.2019.101502}, abstractNote={This cost of illness analysis computes a baseline and future estimate of lifetime social costs associated with autism spectrum disorder (ASD) for the 50 states in the United States (US). The number of cases of ASD are estimated, then multiplied by annual direct and indirect medical and non-medical costs identified in the peer-reviewed literature. This amount is then extrapolated across the number of years each cost type is expected to be incurred to calculate a total lifetime cost for each state in the US from 1990–2019, and to project future cost for 2020–2029. From 1990–2019, there have been an estimated 2 million new cases of (ASD), with social costs of more than $7 trillion. If the future prevalence of ASD remains unchanged over the next decade, there will be an estimated additional 1 million new cases, resulting in an additional $4 trillion to the United States in social costs, however if the rate of increase in prevalence continues, costs could reach nearly $15 trillion by 2029. The financial burden of ASD is significant and identifying the modifiable causes of ASD has the potential to provide tangible benefits.}, journal={RESEARCH IN AUTISM SPECTRUM DISORDERS}, author={Cakir, Janet and Frye, Richard E. and Walker, Stephen J.}, year={2020}, month={Apr} }