@article{zhang_zheng_lee_hoover_king_chen_zhao_lin_yu_zhu_et al._2023, title={Continuous Glucose Monitoring Enabled by Fluorescent Nanodiamond Boronic Hydrogel}, volume={10}, url={http://dx.doi.org/10.1002/advs.202203943}, DOI={10.1002/advs.202203943}, abstractNote={Abstract Continuous monitoring of glucose allows diabetic patients to better maintain blood glucose level by altering insulin dosage or diet according to prevailing glucose values and thus to prevent potential hyperglycemia and hypoglycemia. However, current continuous glucose monitoring (CGM) relies mostly on enzyme electrodes or micro‐dialysis probes, which suffer from insufficient stability, susceptibility to corrosion of electrodes, weak or inconsistent correlation, and inevitable interference. A fluorescence‐based glucose sensor in the skin will likely be more stable, have improved sensitivity, and can resolve the issues of electrochemical interference from the tissue. This study develops a fluorescent nanodiamond boronic hydrogel system in porous microneedles for CGM. Fluorescent nanodiamond is one of the most photostable fluorophores with superior biocompatibility. When surface functionalized, the fluorescent nanodiamond can integrate with boronic polymer and form a hydrogel, which can produce fluorescent signals in response to environmental glucose concentration. In this proof‐of‐concept study, the strategy for building a miniatured device with fluorescent nanodiamond hydrogel is developed. The device demonstrates remarkable long‐term photo and signal stability in vivo with both small and large animal models. This study presents a new strategy of fluorescence based CGM toward treatment and control of diabetes.}, number={7}, journal={Advanced Science}, publisher={Wiley}, author={Zhang, Jian and Zheng, Yongjun and Lee, Jimmy and Hoover, Alex and King, Sarah Ann and Chen, Lifeng and Zhao, Jing and Lin, Qiuning and Yu, Cunjiang and Zhu, Linyong and et al.}, year={2023}, month={Mar} }
 @article{zhang_zheng_lee_hua_li_panchamukhi_yue_gou_xia_zhu_et al._2021, title={A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing}, url={https://doi.org/10.1038/s41467-021-21964-0}, DOI={10.1038/s41467-021-21964-0}, abstractNote={Abstract Effective healing of skin wounds is essential for our survival. Although skin has strong regenerative potential, dysfunctional and disfiguring scars can result from aberrant wound repair. Skin scarring involves excessive deposition and misalignment of ECM (extracellular matrix), increased cellularity, and chronic inflammation. Transforming growth factor-β (TGFβ) signaling exerts pleiotropic effects on wound healing by regulating cell proliferation, migration, ECM production, and the immune response. Although blocking TGFβ signaling can reduce tissue fibrosis and scarring, systemic inhibition of TGFβ can lead to significant side effects and inhibit wound re-epithelization. In this study, we develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-β inhibitor to achieve spatiotemporal specificity for skin wounds. The material enhances skin wound closure while effectively suppressing scar formation in murine skin wounds and large animal preclinical models. Our study presents a strategy for scarless wound repair.}, journal={Nature Communications}, author={Zhang, Jian and Zheng, Yongjun and Lee, Jimmy and Hua, Jieyu and Li, Shilong and Panchamukhi, Ananth and Yue, Jiping and Gou, Xuewen and Xia, Zhaofan and Zhu, Linyong and et al.}, year={2021}, month={Mar} }
 @article{zhang_jia_kim_yang_wang_shen_xu_yang_wu_2018, title={Construction of versatile multilayered composite nanoparticles from a customized nanogel template}, volume={3}, DOI={10.1016/j.bioactmat.2017.06.003}, abstractNote={We present a highly adaptable design platform for multi-responsive, multilayered composite nanoparticles (MC-NPs) with fine-tunable functional layers. A flexible disulfide-linked nanogel template is obtained by a controlled in-situ gelation method, enabling a high degree of control over each successive layer. From this template, we optimize "smart" biomaterials with biofunctional surfaces, tunable drug release kinetics, and magnetic or pH-responsive functionality, fabricated into MC-NPs for targeted drug release and periosteum-mimetic structures for controlled rhBMP-2 release towards bone tissue formation in-vivo. Such a versatile platform for the design of MC-NPs is a powerful tool that shows considerable therapeutic potential in clinical fields such as oncology and orthopedics.}, number={1}, journal={Bioactive Materials}, publisher={Elsevier BV}, author={Zhang, Jian and Jia, Jinpeng and Kim, Jimin P. and Yang, Fei and Wang, Xing and Shen, Hong and Xu, Sijia and Yang, Jian and Wu, Decheng}, year={2018}, month={Mar}, pages={87–96} }
 @article{zhang_jia_kim_shen_yang_zhang_xu_bi_wang_yang_et al._2017, title={Ionic Colloidal Molding as a Biomimetic Scaffolding Strategy for Uniform Bone Tissue Regeneration}, volume={29}, DOI={10.1002/adma.201605546}, abstractNote={Inspired by the highly ordered nanostructure of bone, nanodopant composite biomaterials are gaining special attention for their ability to guide bone tissue regeneration through structural and biological cues. However, bone malformation in orthopedic surgery is a lingering issue, partly due to the high surface energy of traditional nanoparticles contributing to aggregation and inhomogeneity. Recently, carboxyl‐functionalized synthetic polymers have been shown to mimic the carboxyl‐rich surface motifs of non‐collagenous proteins in stabilizing hydroxyapatite and directing intrafibrillar mineralization in‐vitro. Based on this biomimetic approach, it is herein demonstrated that carboxyl functionalization of poly(lactic‐co‐glycolic acid) can achieve great material homogeneity in nanocomposites. This ionic colloidal molding method stabilizes hydroxyapatite precursors to confer even nanodopant packing, improving therapeutic outcomes in bone repair by remarkably improving mechanical properties of nanocomposites and optimizing controlled drug release, resulting in better cell in‐growth and osteogenic differentiation. Lastly, better controlled biomaterial degradation significantly improved osteointegration, translating to highly regular bone formation with minimal fibrous tissue and increased bone density in rabbit radial defect models. Ionic colloidal molding is a simple yet effective approach of achieving materials homogeneity and modulating crystal nucleation, serving as an excellent biomimetic scaffolding strategy to rebuild natural bone integrity.}, number={17}, journal={Advanced Materials}, publisher={Wiley}, author={Zhang, Jian and Jia, Jinpeng and Kim, Jimin P. and Shen, Hong and Yang, Fei and Zhang, Qiang and Xu, Meng and Bi, Wenzhi and Wang, Xing and Yang, Jian and et al.}, year={2017}, month={Feb}, pages={1605546} }
 @article{zhang_wang_wang_yang_wu_2015, title={Controlled cross-linking strategy for formation of hydrogels, microgels and nanogels}, volume={213}, DOI={10.1016/j.jconrel.2015.05.038}, journal={Journal of Controlled Release}, publisher={Elsevier BV}, author={Zhang, Jian and Wang, Xing and Wang, Linlin and Yang, Fei and Wu, Decheng}, year={2015}, month={Sep}, pages={e25} }
 @article{zhang_yang_shen_wu_2012, title={Controlled Formation of Microgels/Nanogels from a Disulfide-Linked Core/Shell Hyperbranched Polymer}, volume={1}, DOI={10.1021/mz300489n}, abstractNote={A general approach to controlled formation of microgels/nanogels is developed for producing hydrogel particles with customizable structures and properties, especially for fabricating multilayered hydrogel particles with flexibly designable structures and properties of each layer. An inverse emulsion technique is adopted to obtain micro- or nanodroplets of a disulfide-linked core/shell hyperbranched polymer. Then pH of the droplets is manipulated to trigger and control in situ core/shell separation of the polymer, dissociation of the shells, and cross-linking of the cores, in the confined space at micro/nanoscales. Loose and compact microgels/nanogels with diverse properties like particle size and swelling capacity are yielded via adjusting the gelation time. Multilayered hydrogel particles with each tailor-made layer are further prepared using the controlled in situ gelation method in association with a seed emulsion technique.}, number={11}, journal={ACS Macro Letters}, publisher={American Chemical Society (ACS)}, author={Zhang, Jian and Yang, Fei and Shen, Hong and Wu, Decheng}, year={2012}, month={Oct}, pages={1295–1299} }