Jiahui Zhang

College of Sciences

Works (5)

Updated: February 21st, 2024 05:01

2023 journal article

Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

ELIFE, 12.

By: T. Kandola*, S. Venkatesan *, J. Zhang n, B. Lerbakken*, A. Von Schulze *, J. Blanck*, J. Wu*, J. Unruh * ...

author keywords: amyloid; phase separation; Huntington's disease; polyglutamine; aging; S. cerevisiae
TL;DR: By uncovering the physical nature of the rate-limiting event for polyQ aggregation in cells, the findings elucidate the molecular etiology of polyQ diseases and show that self-poisoning can be exploited to block amyloid formation. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 19, 2024

2022 article

Novel eGZ-motif formed by regularly extruded guanine bases in a left-handed Z-DNA helix as a major motif behind CGG trinucleotide repeats

Fakharzadeh, A., Zhang, J., Roland, C., & Sagui, C. (2022, May 10). NUCLEIC ACIDS RESEARCH.

By: A. Fakharzadeh n, J. Zhang n, C. Roland n & C. Sagui n

MeSH headings : Base Pairing; DNA / chemistry; DNA / genetics; DNA, Z-Form; Guanine / chemistry; Nucleic Acid Conformation; Trinucleotide Repeats / genetics
TL;DR: Characterization of the stability and structural features (especially overall left-handedness, higher-temperature and steered MD simulations) identified two novel Z-DNA helices: the most stable one displays alternately extruded Gs, and is followed by a helix with symmetrically extruded ZZ junctions. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: May 23, 2022

2022 journal article

RNA as a Major-Groove Ligand: RNA-RNA and RNA-DNA Triplexes Formed by GAA and UUC or TTC Sequences

ACS OMEGA, 7(43), 38728–38743.

By: J. Zhang n, A. Fakharzadeh n, C. Roland n & C. Sagui n

TL;DR: An in silico investigation of all possible triplexes that form by attaching a third RNA strand to an RNA:RNA or DNA:DNA duplex, complementing previous DNA-based triplex studies and allowing for the emergence of a complete picture of the stability and structural characteristics of triPlexes based on the GAA and TTC/UUC sequences. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 21, 2022

2021 journal article

Construction of DNA/RNA Triplex Helices Based on GAA/TTC Trinucleotide Repeats

BIO-PROTOCOL, 11(18).

By: J. Zhang n, A. Fakharzadeh n, F. Pan *, C. Roland n & C. Sagui n

author keywords: DNA/RNA; Triplex helices; Molecular dynamics; Trinucleotide repeats
TL;DR: This protocol illustrates how to build up more generalized DNA triplexes and DNA/RNA mixed hybrids formed from GAA/TTC trinucleotide repeats, which underlie Friedreich's ataxia. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: October 26, 2021

2020 journal article

Atypical structures of GAA/TTC trinucleotide repeats underlying Friedreich's ataxia: DNA triplexes and RNA/DNA hybrids

NUCLEIC ACIDS RESEARCH, 48(17), 9899–9917.

By: J. Zhang n, A. Fakharzadeh n, F. Pan n, C. Roland n & C. Sagui n

MeSH headings : DNA / chemistry; Friedreich Ataxia / genetics; Humans; Nucleic Acid Heteroduplexes / chemistry; R-Loop Structures; Trinucleotide Repeats
TL;DR: A systematic in silico characterization of the possible DNA triplexes that could be assembled with GAA and TTC strands contributes to a systematic structural basis for the emerging field of quantitative R-loop biology. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 4, 2021

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2025) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.