Jiahui Zhang
College of Sciences
Works (5)
Updated: February 21st, 2024 05:01
2023 journal article
Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal
ELIFE, 12.
author keywords: amyloid; phase separation; Huntington's disease; polyglutamine; aging; S. cerevisiae
TL;DR:
By uncovering the physical nature of the rate-limiting event for polyQ aggregation in cells, the findings elucidate the molecular etiology of polyQ diseases and show that self-poisoning can be exploited to block amyloid formation.
(via Semantic Scholar)
open access via github.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 19, 2024
2022 article
Novel eGZ-motif formed by regularly extruded guanine bases in a left-handed Z-DNA helix as a major motif behind CGG trinucleotide repeats
Fakharzadeh, A., Zhang, J., Roland, C., & Sagui, C. (2022, May 10). NUCLEIC ACIDS RESEARCH.
MeSH headings : Base Pairing; DNA / chemistry; DNA / genetics; DNA, Z-Form; Guanine / chemistry; Nucleic Acid Conformation; Trinucleotide Repeats / genetics
TL;DR:
Characterization of the stability and structural features (especially overall left-handedness, higher-temperature and steered MD simulations) identified two novel Z-DNA helices: the most stable one displays alternately extruded Gs, and is followed by a helix with symmetrically extruded ZZ junctions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: May 23, 2022
2022 journal article
RNA as a Major-Groove Ligand: RNA-RNA and RNA-DNA Triplexes Formed by GAA and UUC or TTC Sequences
ACS OMEGA, 7(43), 38728–38743.
TL;DR:
An in silico investigation of all possible triplexes that form by attaching a third RNA strand to an RNA:RNA or DNA:DNA duplex, complementing previous DNA-based triplex studies and allowing for the emergence of a complete picture of the stability and structural characteristics of triPlexes based on the GAA and TTC/UUC sequences.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: November 21, 2022
2021 journal article
Construction of DNA/RNA Triplex Helices Based on GAA/TTC Trinucleotide Repeats
BIO-PROTOCOL, 11(18).
author keywords: DNA/RNA; Triplex helices; Molecular dynamics; Trinucleotide repeats
TL;DR:
This protocol illustrates how to build up more generalized DNA triplexes and DNA/RNA mixed hybrids formed from GAA/TTC trinucleotide repeats, which underlie Friedreich's ataxia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 26, 2021
2020 journal article
Atypical structures of GAA/TTC trinucleotide repeats underlying Friedreich's ataxia: DNA triplexes and RNA/DNA hybrids
NUCLEIC ACIDS RESEARCH, 48(17), 9899–9917.
MeSH headings : DNA / chemistry; Friedreich Ataxia / genetics; Humans; Nucleic Acid Heteroduplexes / chemistry; R-Loop Structures; Trinucleotide Repeats
TL;DR:
A systematic in silico characterization of the possible DNA triplexes that could be assembled with GAA and TTC strands contributes to a systematic structural basis for the emerging field of quantitative R-loop biology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: January 4, 2021
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