Jiahui Zhang

College of Sciences

Works (5)

Updated: April 24th, 2025 11:45

2023 article

Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

Kandola, T., Venkatesan, S., Zhang, J., Lerbakken, B. T., Schulze, A. V., Blanck, J. F., … Halfmann, R. (2023, June 13). ELife, Vol. 12.

By: T. Kandola*, S. Venkatesan *, J. Zhang n, B. Lerbakken*, A. Schulze *, J. Blanck*, J. Wu*, J. Unruh * ...

author keywords: amyloid; phase separation; Huntington's disease; polyglutamine; aging; S. cerevisiae
MeSH headings : Polymers; Peptides / chemistry; Amyloid / chemistry; Amyloidogenic Proteins
topics (OpenAlex): Genetic Neurodegenerative Diseases; RNA Research and Splicing; Fungal and yeast genetics research; Metabolism and Genetic Disorders; Prion Diseases and Protein Misfolding
TL;DR: By uncovering the physical nature of the rate-limiting event for polyQ aggregation in cells, the findings elucidate the molecular etiology of polyQ diseases and show that self-poisoning can be exploited to block amyloid formation. (via Semantic Scholar)
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Added: February 19, 2024

2022 article

Novel eGZ-motif formed by regularly extruded guanine bases in a left-handed Z-DNA helix as a major motif behind CGG trinucleotide repeats

Fakharzadeh, A., Zhang, J., Roland, C., & Sagui, C. (2022, May 6). Nucleic Acids Research, Vol. 5.

By: A. Fakharzadeh n, J. Zhang n, C. Roland n  & C. Sagui n 

MeSH headings : Base Pairing; DNA / chemistry; DNA / genetics; DNA, Z-Form; Guanine / chemistry; Nucleic Acid Conformation; Trinucleotide Repeats / genetics
topics (OpenAlex): DNA and Nucleic Acid Chemistry; RNA and protein synthesis mechanisms; Genomics and Chromatin Dynamics
TL;DR: Characterization of the stability and structural features (especially overall left-handedness, higher-temperature and steered MD simulations) identified two novel Z-DNA helices: the most stable one displays alternately extruded Gs, and is followed by a helix with symmetrically extruded ZZ junctions. (via Semantic Scholar)
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Added: May 23, 2022

2022 article

RNA as a Major-Groove Ligand: RNA–RNA and RNA–DNA Triplexes Formed by GAA and UUC or TTC Sequences

Zhang, J., Fakharzadeh, A., Roland, C., & Sagui, C. (2022, October 24). ACS Omega, Vol. 7, pp. 38728–38743.

By: J. Zhang n, A. Fakharzadeh n, C. Roland n  & C. Sagui n 

topics (OpenAlex): Genetic Neurodegenerative Diseases; RNA and protein synthesis mechanisms; RNA Research and Splicing
TL;DR: An in silico investigation of all possible triplexes that form by attaching a third RNA strand to an RNA:RNA or DNA:DNA duplex, complementing previous DNA-based triplex studies and allowing for the emergence of a complete picture of the stability and structural characteristics of triPlexes based on the GAA and TTC/UUC sequences. (via Semantic Scholar)
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Added: November 21, 2022

2021 article

Construction of DNA/RNA Triplex Helices Based on GAA/TTC Trinucleotide Repeats

Zhang, J., Fakharzadeh, A., Pan, F., Roland, C., & Sagui, C. (2021, January 1). BIO-PROTOCOL, Vol. 11.

By: J. Zhang n, A. Fakharzadeh n, F. Pan *, C. Roland n  & C. Sagui n 

author keywords: DNA/RNA; Triplex helices; Molecular dynamics; Trinucleotide repeats
topics (OpenAlex): DNA and Nucleic Acid Chemistry; RNA and protein synthesis mechanisms; RNA Research and Splicing
TL;DR: This protocol illustrates how to build up more generalized DNA triplexes and DNA/RNA mixed hybrids formed from GAA/TTC trinucleotide repeats, which underlie Friedreich's ataxia. (via Semantic Scholar)
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Added: October 26, 2021

2020 article

Atypical structures of GAA/TTC trinucleotide repeats underlying Friedreich’s ataxia: DNA triplexes and RNA/DNA hybrids

Zhang, J., Fakharzadeh, A., Pan, F., Roland, C., & Sagui, C. (2020, August 5). Nucleic Acids Research, Vol. 48, pp. 9899–9917.

By: J. Zhang n, A. Fakharzadeh n, F. Pan n, C. Roland n  & C. Sagui n 

MeSH headings : DNA / chemistry; Friedreich Ataxia / genetics; Humans; Nucleic Acid Heteroduplexes / chemistry; R-Loop Structures; Trinucleotide Repeats
topics (OpenAlex): Genetic Neurodegenerative Diseases; DNA Repair Mechanisms; Mitochondrial Function and Pathology
TL;DR: A systematic in silico characterization of the possible DNA triplexes that could be assembled with GAA and TTC strands contributes to a systematic structural basis for the emerging field of quantitative R-loop biology. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 4, 2021

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