Katherine A. McCaffrey

Works (5)

Updated: July 5th, 2023 15:46

2013 journal article

Sex specific impact of perinatal bisphenol A (BPA) exposure over a range of orally administered doses on rat hypothalamic sexual differentiation

NEUROTOXICOLOGY, 36, 55–62.

By: K. McCaffrey n, B. Jones *, N. Mabrey n, B. Weiss *, S. Swan * & H. Patisaul n 

author keywords: Endocrine disruption; Estrogen; Hypothalamus; Sexually dimorphic; Dopamine
MeSH headings : Administration, Oral; Air Pollutants, Occupational / toxicity; Analysis of Variance; Animals; Benzhydryl Compounds / administration & dosage; Benzhydryl Compounds / toxicity; Calbindins / metabolism; Cell Count; Dose-Response Relationship, Drug; Female; Hypothalamus / drug effects; Hypothalamus / metabolism; Male; Phenols / administration & dosage; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Rats; Rats, Long-Evans; Sex Differentiation / physiology; Tyrosine 3-Monooxygenase / metabolism
TL;DR: It is demonstrated that early life oral exposure to BPA at levels well below the current No Observed Adverse Effect Level (NOAEL) of 50mg/kg/day can alter sex specific hypothalamic morphology in the rat. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Accumulation and Endocrine Disrupting Effects of the Flame Retardant Mixture Firemaster®550 in Rats: An Exploratory Assessment

Journal of Biochemical and Molecular Toxicology, 27(2), 124–136.

By: H. Patisaul n , S. Roberts*, N. Mabrey n, K. McCaffrey n, R. Gear*, J. Braun *, S. Belcher* , H. Stapleton *

Contributors: H. Patisaul n , S. Roberts*, N. Mabrey n, K. Mccaffrey n, R. Gear*, J. Braun *, S. Belcher* , H. Stapleton *

author keywords: Anxiety; Cardiac Hypertrophy; Endocrine Disruptor; Flame Retardants; Metabolic Syndrome; Metabolism; Obesity; Obesogen; Polybrominated Diphenyl Ethers; Rodents
MeSH headings : Animals; Cardiomegaly / blood; Cardiomegaly / chemically induced; Cardiomegaly / pathology; Endocrine System / metabolism; Endocrine System / pathology; Endocrine System / physiology; Female; Flame Retardants / adverse effects; Male; Maternal Exposure / adverse effects; Obesity / blood; Obesity / chemically induced; Obesity / pathology; Pregnancy; Prenatal Exposure Delayed Effects / blood; Prenatal Exposure Delayed Effects / pathology; Rats; Rats, Wistar; Thyroxine / blood
TL;DR: Results are the first to implicate FM 550 as an endocrine disruptor and an obesogen at environmentally relevant levels and induced phenotypic hallmarks associated with metabolic syndrome in the offspring. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2012 journal article

Ants of North Carolina: An updated list (Hymenoptera: Formicidae)

Zootaxa, (3552), 1–36.

By: B. Guenard, K. Mccaffrey, A. Lucky & R. Dunn 

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Disrupted Organization of RFamide Pathways in the Hypothalamus Is Associated with Advanced Puberty in Female Rats Neonatally Exposed to Bisphenol A

BIOLOGY OF REPRODUCTION, 87(2).

By: S. Losa-Ward n, K. Todd n, K. McCaffrey n, K. Tsutsui * & H. Patisaul n 

author keywords: endocrine disruptor; kisspeptin; puberty; RFRP
MeSH headings : Animals; Benzhydryl Compounds; Body Weight / drug effects; Estrogens, Non-Steroidal / toxicity; Female; Gonadotropin-Releasing Hormone / metabolism; Hypothalamus / drug effects; Kisspeptins / metabolism; Male; Neuropeptides / metabolism; Phenols / toxicity; Puberty, Precocious / blood; Puberty, Precocious / chemically induced; Rats; Rats, Transgenic; Rats, Wistar; Vagina / drug effects
TL;DR: Data suggest that BPA-induced premature puberty results from decreased inhibition of GnRH neurons, which are critical for initiating puberty and maintaining estrous cyclicity by stimulating gonadotropin-releasing hormone (GnRH) release. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Sexual Phenotype Differences in zic2 mRNA Abundance in the Preoptic Area of a Protogynous Teleost, Thalassoma bifasciatum

PLOS ONE, 6(8).

By: K. McCaffrey n, M. Hawkins n & J. Godwin n 

MeSH headings : Animals; Female; Fishes / genetics; Fishes / metabolism; Hypothalamus / metabolism; Male; RNA, Messenger / genetics; Sexual Behavior, Animal / physiology; Transcription Factors / genetics
TL;DR: Sexual phenotype differences in abundances of zic2 mRNA in the preoptic area of the hypothalamus, a region strongly implicated in sexual behavior and function, in an adult teleost, Thalassoma bifasciatum is described. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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