Kevin Bryant Flores

Works (41)

Updated: August 15th, 2023 21:15

2023 journal article

Estimation of Parameter Distributions for Reaction-Diffusion Equations with Competition using Aggregate Spatiotemporal Data

BULLETIN OF MATHEMATICAL BIOLOGY, 85(7).

By: K. Nguyen n, E. Rutter* & K. Flores n

author keywords: Glioblastoma multiforme; Random differential equation; Parameter estimation; k-Means clustering
MeSH headings : Humans; Mathematical Concepts; Models, Biological; Brain Neoplasms; Glioblastoma
Source: Web Of Science
Added: June 19, 2023

2022 journal article

Multitask neural networks for predicting bladder pressure with time series data

BIOMEDICAL SIGNAL PROCESSING AND CONTROL, 72.

By: S. Warrier n, E. Rutter* & K. Flores n

author keywords: Multitask neural networks; Recurrent neural networks; Time series data; Bladder dysfunction; Bladder contraction; Spectrogram
Source: Web Of Science
Added: November 29, 2021

2021 journal article

Deep Learning Approach to the Detection of Scattering Delay in Radar Images

JOURNAL OF STATISTICAL THEORY AND PRACTICE, 15(1).

By: J. Lagergren n, K. Flores n, M. Gilman n & S. Tsynkov n

author keywords: Radar imaging; Dispersive targets; Classification; Convolutional neural network
Sources: Web Of Science, ORCID
Added: January 4, 2021

2021 journal article

Deep learning and regression approaches to forecasting blood glucose levels for type 1 diabetes

BIOMEDICAL SIGNAL PROCESSING AND CONTROL, 69.

By: M. Zhang n, K. Flores n & H. Tran n

author keywords: Neural networks; Regression; Encoder decoder; Time series forecasting; Diabetes
Sources: Web Of Science, ORCID
Added: August 30, 2021

2021 review

Learning differential equation models from stochastic agent-based model simulations

[Review of ]. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 18(176).

By: J. Nardini n, R. Baker*, M. Simpson* & K. Flores n

author keywords: agent-based models; differential equations; equation learning; population dynamics; disease dynamics
MeSH headings : Learning; Models, Biological; Molecular Dynamics Simulation; Monte Carlo Method; Stochastic Processes
Source: Web Of Science
Added: April 12, 2021

2021 article

Predicting Inter-individual Variability During Lipid Resuscitation of Bupivacaine Cardiotoxicity in Rats: A Virtual Population Modeling Study

McDaniel, M., Flores, K. B., & Akpa, B. S. (2021, July 19). DRUGS IN R&D, Vol. 7.

By: M. McDaniel n, K. Flores n & B. Akpa n

MeSH headings : Anesthetics, Local / toxicity; Animals; Bupivacaine / toxicity; Cardiotoxicity; Lipids; Rats; Rats, Sprague-Dawley
Sources: Web Of Science, ORCID
Added: July 20, 2021

2021 journal article

Stoichiometric Ecotoxicology for a Multisubstance World

BIOSCIENCE, 71(2), 132–147.

By: A. Peace*, P. Frost*, N. Wagner*, M. Danger*, C. Accolla*, P. Antczak, B. Brooks*, D. Costello* ...

author keywords: nutrient ratios; elemental imbalances; toxicity; ecotoxicological models; multiple stressors
Source: Web Of Science
Added: May 24, 2021

2021 journal article

Topological data analysis distinguishes parameter regimes in the Anderson-Chaplain model of angiogenesis

PLOS COMPUTATIONAL BIOLOGY, 17(6).

MeSH headings : Algorithms; Animals; Blood Vessels / anatomy & histology; Blood Vessels / growth & development; Blood Vessels / physiology; Chemotaxis; Computational Biology; Computer Simulation; Humans; Models, Cardiovascular; Neoplasms / blood supply; Neovascularization, Pathologic; Neovascularization, Physiologic; Spatio-Temporal Analysis
Source: Web Of Science
Added: July 19, 2021

2020 review

A tutorial review of mathematical techniques for quantifying tumor heterogeneity

[Review of ]. MATHEMATICAL BIOSCIENCES AND ENGINEERING, 17(4), 3660–3709.

By: R. Everett*, K. Flores*, N. Henscheid, J. Lagergren*, K. Larripa, D. Li, J. Nardini*, P. Nguyen*, E. Pitman, E. Rutter*

author keywords: cancer heterogeneity; mathematical oncology; tumor growth; glioblastoma multiforme; virtual populations; nonlinear mixed effects; spatiotemporal data; Bayesian estimation; generative; adversarial networks; non-parametric estimation; variational autoencoders; machine learning
MeSH headings : Bayes Theorem; Humans; Machine Learning; Models, Theoretical; Neoplasms; Precision Medicine
Source: Web Of Science
Added: August 3, 2020

2020 journal article

Biologically-informed neural networks guide mechanistic modeling from sparse experimental data

PLOS COMPUTATIONAL BIOLOGY, 16(12).

MeSH headings : Computer Simulation; Machine Learning; Neural Networks, Computer; Nonlinear Dynamics
Source: Web Of Science
Added: January 4, 2021

2020 journal article

Deep learning-enabled analysis reveals distinct neuronal phenotypes induced by aging and cold-shock

BMC BIOLOGY, 18(1).

By: S. Saberi-Bosari n, K. Flores n & A. San-Miguel n

author keywords: Deep learning; Convolutional neural networks; Neurodegeneration; Neuronal beading; Aging; Machine learning; Phenotyping; C; elegans
MeSH headings : Aging / physiology; Animals; Caenorhabditis elegans / physiology; Cold-Shock Response / physiology; Deep Learning; Neurons / physiology; Phenotype
Sources: Web Of Science, ORCID
Added: October 26, 2020

2020 journal article

Learning Equations from Biological Data with Limited Time Samples

BULLETIN OF MATHEMATICAL BIOLOGY, 82(9).

By: J. Nardini n, J. Lagergren n, A. Hawkins-Daarud*, L. Curtin*, B. Morris*, E. Rutter*, K. Swanson*, K. Flores n

author keywords: Equation learning; Numerical differentiation; Sparse regression; Model selection; Partial differential equations; Parameter estimation; Population dynamics; Glioblastoma multiforme
MeSH headings : Computational Biology / methods; Glioblastoma; Humans; Learning; Mathematical Concepts; Models, Biological; Nonlinear Dynamics
Source: Web Of Science
Added: September 28, 2020

2020 journal article

Learning partial differential equations for biological transport models from noisy spatio-temporal data

By: J. Lagergren n, J. Nardini n, G. Michael Lavigne n, E. Rutter n & K. Flores n

author keywords: numerical differentiation; equation learning; sparse regression; partial differential equations; parameter estimation; biological transport
Source: Web Of Science
Added: March 30, 2020

2020 article

Lifelong Analysis of Key Aging Genes as Determinants of Lifespan in C. elegans

San Miguel, A., Ramirez, J., & Flores, K. (2020, April). FASEB JOURNAL, Vol. 34.

By: A. San Miguel n, J. Ramirez n & K. Flores n

Sources: Web Of Science, ORCID
Added: October 12, 2020

2018 article

Automated Object Tracing for Biomedical Image Segmentation Using a Deep Convolutional Neural Network

MEDICAL IMAGE COMPUTING AND COMPUTER ASSISTED INTERVENTION - MICCAI 2018, PT IV, Vol. 11073, pp. 686–694.

By: E. Rutter n, J. Lagergren n & K. Flores n

Source: Web Of Science
Added: August 12, 2019

2018 journal article

Detection of Bladder Contractions From the Activity of the External Urethral Sphincter in Rats Using Sparse Regression

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 26(8), 1636–1644.

By: E. Rutter n, C. Langdale*, J. Hokanson*, F. Hamilton n, H. Tran n, W. Grill*, K. Flores n

author keywords: LASSO; neural stimulation; bladder dysfunction; spectrogram
MeSH headings : Algorithms; Animals; Computer Simulation; Electromyography; Female; Models, Theoretical; Muscle Contraction / physiology; Pudendal Nerve; Rats; Rats, Wistar; Urethra / physiology; Urinary Bladder / physiology; Urinary Incontinence / rehabilitation
Sources: Crossref, ORCID
Added: July 20, 2019

2018 journal article

Estimating intratumoral heterogeneity from spatiotemporal data

JOURNAL OF MATHEMATICAL BIOLOGY, 77(6-7), 1999–2022.

By: E. Rutter n, H. Banks n & K. Flores n

author keywords: Glioblastoma multiforme; Random differential equation; Parameter estimation
MeSH headings : Antineoplastic Agents / therapeutic use; Brain Neoplasms / drug therapy; Brain Neoplasms / pathology; Cell Movement; Cell Proliferation; Computer Simulation; Glioblastoma / drug therapy; Glioblastoma / pathology; Humans; Mathematical Concepts; Models, Biological; Neoplasm Invasiveness / pathology; Phenotype; Probability; Spatio-Temporal Analysis; Tumor Burden / drug effects
Source: Web Of Science
Added: December 17, 2018

2018 journal article

Forecasting and Uncertainty Quantification Using a Hybrid of Mechanistic and Non-mechanistic Models for an Age-Structured Population Model

Bulletin of Mathematical Biology, 80(6), 1578–1595.

By: J. Lagergren n, A. Reeder n, F. Hamilton n, R. Smith n & K. Flores n

author keywords: State space reconstruction; Uncertainty quantification; Structured population model; Forecasting
MeSH headings : Animals; Bayes Theorem; Coleoptera / pathogenicity; Coleoptera / physiology; Forecasting / methods; Mathematical Concepts; Models, Biological; Multivariate Analysis; Population Dynamics / statistics & numerical data; Uncertainty
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2017 journal article

Continuous Structured Population Models for Daphnia magna

Bulletin of Mathematical Biology, 79(11), 2627–2648.

By: E. Rutter n, H. Banks n, G. LeBlanc n & K. Flores n

author keywords: Continuous structured population models; Inverse problems; Generalized least squares; Model selection; Information content; Residual plots
MeSH headings : Animals; Computer Simulation; Confidence Intervals; Daphnia / growth & development; Daphnia / physiology; Female; Fertility; Food; Least-Squares Analysis; Male; Mathematical Concepts; Models, Biological; Population Dynamics
Source: Crossref
Added: July 20, 2019

2017 journal article

Estimating the rate of prion aggregate amplification in yeast with a generation and structured population model

Inverse Problems in Science and Engineering, 26(2), 257–279.

author keywords: Structured population model; aggregate data; inverse problem; PDEs; prion; General biology and biomathematics
Source: Crossref
Added: July 20, 2019

2017 journal article

Hybrid modeling and prediction of dynamical systems

PLoS Computational Biology, 13(7).

By: F. Hamilton, A. Lloyd & K. Flores

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Statistical error model comparison for logistic growth of green algae (Raphidocelis subcapitata)

Applied Mathematics Letters, 64, 213–222.

By: H. Banks n, E. Collins n, K. Flores n, P. Pershad n, M. Stemkovski n & L. Stephenson n

author keywords: Algae growth models; Parameter estimation; Uncertainty quantification; Asymptotic theory
Sources: Crossref, Web Of Science
Added: August 6, 2018

2016 journal article

Build to understand: synthetic approaches to biology

Integrative Biology, 8(4), 394–408.

By: L. Wang*, F. Wu*, K. Flores n, Y. Lai* & X. Wang*

MeSH headings : Animals; Bacillus subtilis / genetics; Cell Communication; Computer Simulation; Feedback, Physiological; Gene Expression; Gene Regulatory Networks; Humans; Models, Genetic; N-Acetylmuramoyl-L-alanine Amidase / chemistry; Oscillometry; Stochastic Processes; Synthetic Biology / methods
Source: Crossref
Added: July 20, 2019

2016 journal article

On analytical and numerical approaches to division and label structured population models

APPLIED MATHEMATICS LETTERS, 60, 81–88.

By: H. Banks n, K. Flores n & S. Sindi*

author keywords: Division-structured population model; Heterogeneous cell populations; Protein dynamics
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Validation of a mathematical model for green algae (Raphidocelis Subcapitata) growth and implications for a coupled dynamical system with Daphnia magna

Applied Sciences-Basel, 6(5).

By: M. Stemkovski, R. Baraldi, K. Flores & H. Banks

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Correlation of parameter estimators for models admitting multiple parametrizations

International Journal of Pure and Applied Mathematics, 105(3), 497–522.

By: K. Adoteye, R. Baraldi, K. Flores, J. Nardini, H. Banks & W. Thompson

Source: Crossref
Added: August 18, 2019

2015 journal article

Estimation of time-varying mortality rates using continuous models for Daphnia magna

APPLIED MATHEMATICS LETTERS, 44, 12–16.

By: K. Adoteye n, H. Banks n, K. Flores n & G. LeBlanc n

author keywords: Structured population model; Leslie matrix model; Sinko-Streifer model; Daphnia magna; Time-dependent mortality rate
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Immuno-modulatory strategies for reduction of HIV reservoir cells

JOURNAL OF THEORETICAL BIOLOGY, 372, 146–158.

By: H. Banks n, K. Flores n, S. Hu n, E. Rosenberg*, M. Buzon*, X. Yu*, M. Lichterfeld*

author keywords: Immune response; Mathematical model; Inverse problem; Stability analysis
MeSH headings : Anti-HIV Agents / chemistry; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / virology; Cell Proliferation; Computer Simulation; HIV Infections / immunology; HIV Infections / therapy; HIV-1; Homeostasis; Humans; Models, Biological; Viral Load; Virus Latency
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Optimal design for minimizing uncertainty in dynamic equilibrium systems

Eurasian Journal of Mathematical and Computer Applications, 3(1), 23–47.

By: H. Banks, R. Baraldi & K. Flores

Source: NC State University Libraries
Added: July 10, 2019

2015 journal article

Optimal design of non-equilibrium experiments for genetic network interrogation

APPLIED MATHEMATICS LETTERS, 40, 84–89.

By: K. Adoteye n, H. Banks n & K. Flores n

author keywords: Optimal experimental design; Inverse problem; Uncertainty analysis; Brome mosaic virus; Synthetic biology; Genetic networks
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Statistical validation of structured population models for Daphnia magna

Mathematical Biosciences, 266, 73–84.

By: K. Adoteye n, H. Banks n, K. Cross n, S. Eytcheson n, K. Flores n, G. LeBlanc n, T. Nguyen n, C. Ross n ...

author keywords: Sensitivity analysis; Structured population model; Uncertainty quantification; Density-dependence; Multi-scale data; Daphnia magna
MeSH headings : Animals; Daphnia; Models, Statistical; Population Dynamics
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2015 journal article

The genomes of two key bumblebee species with primitive eusocial organization

Genome Biology, 16.

By: B. Sadd, S. Barribeau, G. Bloch, D. Graaf, P. Dearden, C. Elsik, J. Gadau, C. Grimmelikhuijzen ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

UNCERTAINTY QUANTIFICATION IN MODELING HIV VIRAL MECHANICS

MATHEMATICAL BIOSCIENCES AND ENGINEERING, 12(5), 937–964.

By: H. Banks n, R. Baraldi*, K. Cross*, K. Flores*, C. Mcchesney*, L. Poag*, E. Thorpe n

MeSH headings : Algorithms; Anti-HIV Agents / therapeutic use; CD4-Positive T-Lymphocytes / virology; Clinical Trials as Topic; HIV Infections / drug therapy; HIV Infections / physiopathology; HIV Infections / virology; HIV-1 / physiology; Humans; Least-Squares Analysis; Models, Biological; Models, Statistical; RNA, Viral / analysis; Reverse Transcriptase Inhibitors / therapeutic use; Uncertainty; Viral Load
Source: Web Of Science
Added: August 6, 2018

2014 conference paper

Uncertainty quantification for a model of HIV-1 patient response to antiretroviral therapy interruptions

2014 american control conference (acc), 2753–2758.

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

A mathematical model of RNA3 recruitment in the replication cycle of Brome Mosaic Virus

International Journal of Pure and Applied Mathematics, 89(2), 251–274.

By: T. Huffman, K. Link, J. Nardini, L. Poag, K. Flores, H. Banks, B. Blasco, J. Jungfleisch, J. Diez

Source: Crossref
Added: August 18, 2019

2013 journal article

A structured population modeling framework for quantifying and predicting gene expression noise in flow cytometry data

APPLIED MATHEMATICS LETTERS, 26(7), 794–798.

By: K. Flores n

author keywords: Structured population models; Distributed parameters; Gene regulatory networks; Gene expression noise; Synthetic biology
Source: Web Of Science
Added: August 6, 2018

2013 journal article

DATA AND IMPLICATION BASED COMPARISON OF TWO CHRONIC MYELOID LEUKEMIA MODELS

MATHEMATICAL BIOSCIENCES AND ENGINEERING, 10(5-6), 1501–1518.

By: R. Everett, Y. Zhao, K. Flores* & Y. Kuang

author keywords: Chronic myeloid leukemia; clinical data; drug resistance; cancer modeling
MeSH headings : Algorithms; Benzamides / administration & dosage; Computer Simulation; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl / metabolism; Hematopoietic Stem Cells / metabolism; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive / epidemiology; Leukemia, Myelogenous, Chronic, BCR-ABL Positive / physiopathology; Models, Biological; Mutation; Piperazines / administration & dosage; Pyrimidines / administration & dosage; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome
Source: Web Of Science
Added: August 6, 2018

2013 journal article

The Role of Methylation of DNA in Environmental Adaptation

Integrative and Comparative Biology, 53(2), 359–372.

By: K. Flores*, F. Wolschin* & G. Amdam

MeSH headings : Adaptation, Physiological / genetics; Animals; Base Sequence / genetics; Bees / genetics; Bees / physiology; DNA Methylation / genetics; Environment; Evolution, Molecular; Genetic Variation; Genome, Insect / genetics; Mutation / genetics; Phenotype
Source: Crossref
Added: July 20, 2019

2012 journal article

Genome-wide association between DNA methylation and alternative splicing in an invertebrate

BMC Genomics, 13(1), 480.

By: K. Flores*, F. Wolschin*, J. Corneveaux*, A. Allen*, M. Huentelman* & G. Amdam*

MeSH headings : Alternative Splicing; Animals; Base Sequence; Bees / genetics; Conserved Sequence; CpG Islands; DNA Methylation; Evolution, Molecular; Exons / genetics; Gene Expression Profiling; Genes, Insect; Genome-Wide Association Study; Molecular Sequence Data; Sequence Analysis, RNA; Transcriptome; Wasps / genetics
Source: Crossref
Added: July 20, 2019

2011 journal article

Deciphering a methylome: what can we read into patterns of DNA methylation?

Journal of Experimental Biology, 214(19), 3155–3163.

By: K. Flores* & G. Amdam*

author keywords: CG methylation; DNA sequencing; genome analysis; honeybee genome; epigenetics
MeSH headings : Animals; Bees / genetics; Computational Biology / methods; Cytosine / metabolism; DNA Methylation / genetics; Epigenomics / methods; Genome / genetics
Source: Crossref
Added: July 20, 2019

2010 journal article

The random walk of Azospirillum brasilense

Journal of Biological Dynamics, 4(1), 71–85.

By: K. Flores* & K. Hadeler*

MeSH headings : Azospirillum brasilense / physiology; Models, Biological; Movement
Source: Crossref
Added: July 20, 2019