Ke Cheng

Cheng, X., Henick, B. S., & Cheng, K. (2024, February 23). Anticancer Therapy Targeting Cancer-Derived Extracellular Vesicles. ACS NANO. https://doi.org/10.1021/acsnano.3c06462

Liu, M., Hu, S., Yan, N., Popowski, K. D., & Cheng, K. (2024, January 11). Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity. NATURE NANOTECHNOLOGY, Vol. 1. https://doi.org/10.1038/s41565-023-01580-3

Wang, Z., Hu, S., Popowski, K. D., Liu, S., Zhu, D., Mei, X., … Cheng, K. (2024). Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2. NATURE COMMUNICATIONS, 15(1). https://doi.org/10.1038/s41467-024-45628-x

Wang, Z., Li, Z., Shi, W., Zhu, D., Hu, S., Dinh, P.-U. C., & Cheng, K. (2023). A SARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivated influenza A virus. SCIENCE ADVANCES, 9(25). https://doi.org/10.1126/sciadv.abo4100

Mei, X., Li, J., Wang, Z., Zhu, D., Huang, K., Hu, S., … Cheng, K. (2023). An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection. Nature Materials, 2. https://doi.org/10.1038/s41563-023-01475-7

Wang, X., Hu, S., Zhu, D., Li, J., Cheng, K., & Liu, G. (2023). Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials. NANO RESEARCH, 16(5), 7248–7259. https://doi.org/10.1007/s12274-023-5374-3

Zhu, D., Liu, S., Huang, K., Li, J., Mei, X., Li, Z., & Cheng, K. (2023). Intrapericardial long non-coding RNA–<i>Tcf21</i> antisense RNA inducing demethylation administration promotes cardiac repair. European Heart Journal, 44(19), 1748–1760. https://doi.org/10.1093/eurheartj/ehad114

Cheng, X., Hu, S., & Cheng, K. (2023, June 9). Microneedle Patch Delivery of PROTACs for Anti-Cancer Therapy. ACS NANO, Vol. 6. https://doi.org/10.1021/acsnano.3c03166

Luo, L., Li, Y., Bao, Z., Zhu, D., Chen, G., Li, W., … Li, Z. (2023, September 15). Pericardial Delivery of SDF-1 α Puerarin Hydrogel Promotes Heart Repair and Electrical Coupling. ADVANCED MATERIALS, Vol. 9. https://doi.org/10.1002/adma.202302686

Moatti, A., Cai, Y., Li, C., Popowski, K. D., Cheng, K., Ligler, F. S., & Greenbaum, A. (2023). Tissue clearing and three-dimensional imaging of the whole cochlea and vestibular system from multiple large-animal models. STAR PROTOCOLS, 4(2). https://doi.org/10.1016/j.xpro.2023.102220

Chee, E., Mihalko, E., Nellenbach, K., Sollinger, J., Huang, K., Hon, M., … Brown, A. (2023, October 17). Wound-triggered shape change microgels for the development of enhanced biomimetic function platelet-like particles. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol. 10. https://doi.org/10.1002/jbm.a.37625

Fan, M., Li, H., Shen, D., Wang, Z., Liu, H., Zhu, D., … Li, Z. (2022, September 4). Decoy Exosomes Offer Protection Against Chemotherapy-Induced Toxicity. ADVANCED SCIENCE, Vol. 9. https://doi.org/10.1002/advs.202203505

Hu, S., Zhu, D., Li, Z., & Cheng, K. (2022, September 23). Detachable Microneedle Patches Deliver Mesenchymal Stromal Cell Factor-Loaded Nanoparticles for Cardiac Repair. ACS NANO, Vol. 9. https://doi.org/10.1021/acsnano.2c03060

Fang, J., Li, J. J., Zhong, X., Zhou, Y., Lee, R. J., Cheng, K., & Li, S. (2022). Engineering stem cell therapeutics for cardiac repair. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 171, 56–68. https://doi.org/10.1016/j.yjmcc.2022.06.013

Wang, Z., Popowski, K. D., Zhu, D., Abad, B. L. de J., Wang, X., Liu, M., … Cheng, K. (2022, July 4). Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine. NATURE BIOMEDICAL ENGINEERING, Vol. 7. https://doi.org/10.1038/s41551-022-00902-5

Shi, W., Cheng, X., & Cheng, K. (2022). Gecko-Inspired Adhesives with Asymmetrically Tilting-Oriented Micropillars. LANGMUIR, 38(29). https://doi.org/10.1021/acs.langmuir.2c01002

Popowski, K. D., Moatti, A., Scull, G., Silkstone, D., Lutz, H., López de Juan Abad, B., … Cheng, K. (2022). Inhalable dry powder mRNA vaccines based on extracellular vesicles. Matter, 5(9), 2960–2974. https://doi.org/10.1016/j.matt.2022.06.012

Zhu, D., Liu, S., Huang, K., Wang, Z., Hu, S., Li, J., … Cheng, K. (2022). Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3. CIRCULATION RESEARCH, 131(10), E135–E150. https://doi.org/10.1161/CIRCRESAHA.122.321384

Li, J., Lv, Y., Zhu, D., Mei, X., Huang, K., Wang, X., … Wang, J. (2022). Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction. CHEMICAL ENGINEERING JOURNAL, 427. https://doi.org/10.1016/j.cej.2021.131581

Zhang, C., Zhang, W., Zhu, D., Li, Z., Wang, Z., Li, J., … Zhong, B. (2022). Nanoparticles functionalized with stem cell secretome and CXCR4-overexpressing endothelial membrane for targeted osteoporosis therapy. JOURNAL OF NANOBIOTECHNOLOGY, 20(1). https://doi.org/10.1186/s12951-021-01231-6

Huang, K., & Cheng, K. (2022). Sealing the heart from the inside out. Nature Biomedical Engineering, 7(2), 87–88. https://doi.org/10.1038/s41551-022-00981-4

Liu, Y., Menon, R., Putcha, A., Huang, K., Bonilla, L., Vora, R., … Bai, W. (2022, June 29). Skin-Interfaced Deep-Tissue Sensing Patch via Microneedle Waveguides. ADVANCED MATERIALS TECHNOLOGIES, Vol. 6. https://doi.org/10.1002/admt.202200468

Chingale, M., Cheng, K., & Huang, K. (2021). 3D Bioprinting Technology – One Step Closer Towards Cardiac Tissue Regeneration. Frontiers in Materials, 8. https://doi.org/10.3389/fmats.2021.804134

Yao, J., Huang, K., Zhu, D., Chen, T., Jiang, Y., Zhang, J., … Cheng, K. (2021). A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction. ACS NANO, 15(7), 11099–11111. https://doi.org/10.1021/acsnano.1c00628

Allen, T. A., Cullen, M. M., Hawkey, N., Mochizuki, H., Nguyen, L., Schechter, E., … Somarelli, J. A. (2021). A Zebrafish Model of Metastatic Colonization Pinpoints Cellular Mechanisms of Circulating Tumor Cell Extravasation. FRONTIERS IN ONCOLOGY, 11. https://doi.org/10.3389/fonc.2021.641187

Mei, X., Zhu, D., Li, J., Huang, K., Hu, S., Li, Z., … Cheng, K. (2021). A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs. MED, 2(11), 1253-+. https://doi.org/10.1016/j.medj.2021.10.001

Zhang, S., Zhu, D., Li, Z., Huang, K., Hu, S., Lutz, H., … Cheng, K. (2021). A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency. THERANOSTICS, 11(18), 8894–8908. https://doi.org/10.7150/thno.61690

Xie, M., Li, J., Zhang, S., Zhu, D., Mei, X., Wang, Z., … Cheng, K. (2021). A trifunctional contraceptive gel enhances the safety and quality of sexual intercourse. BIOACTIVE MATERIALS, 6(6), 1777–1788. https://doi.org/10.1016/j.bioactmat.2020.11.031

Zhang, S., Zhu, D., Mei, X., Li, Z., Li, J., Xie, M., … Cheng, K. (2021). [Review of Advances in biomaterials and regenerative medicine for primary ovarian insufficiency therapy]. BIOACTIVE MATERIALS, 6(7), 1957–1972. https://doi.org/10.1016/j.bioactmat.2020.12.008

Li, J., Hu, S., Zhu, D., Huang, K., Mei, X., Abad, B. L. de J., & Cheng, K. (2021). [Review of All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(8). https://doi.org/10.1161/JAHA.120.020402

Chingale, M., Zhu, D., Cheng, K., & Huang, K. (2021). Bioengineering Technologies for Cardiac Regenerative Medicine. Frontiers in Bioengineering and Biotechnology, 9. https://doi.org/10.3389/fbioe.2021.681705

Zhu, D., & Cheng, K. (2021). [Review of Cardiac Cell Therapy for Heart Repair: Should the Cells Be Left Out?]. CELLS, 10(3). https://doi.org/10.3390/cells10030641

Liu, M., Abad, B. L. de J., & Cheng, K. (2021). [Review of Cardiac fibrosis: Myofibroblast-mediated pathological regulation and drug delivery strategies]. ADVANCED DRUG DELIVERY REVIEWS, 173, 504–519. https://doi.org/10.1016/j.addr.2021.03.021

Carter, A., Popowski, K., Cheng, K., Greenbaum, A., Ligler, F. S., & Moatti, A. (2021, September 24). Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation. BIOELECTRICITY, Vol. 9. https://doi.org/10.1089/bioe.2021.0019

Popowski, K. D., Dinh, P.-U. C., George, A., Lutz, H., & Cheng, K. (2021). [Review of Exosome therapeutics for COVID-19 and respiratory viruses]. VIEW, 2(3). https://doi.org/10.1002/VIW.20200186

Hu, S., Li, Z., Shen, D., Zhu, D., Huang, K., Su, T., … Cheng, K. (2021). Exosome-eluting stents for vascular healing after ischaemic injury. NATURE BIOMEDICAL ENGINEERING, 5(10), 1174–1188. https://doi.org/10.1038/s41551-021-00705-0

Wang, X., Hu, S., Li, J., Zhu, D., Wang, Z., Cores, J., … Huang, K. (2021). Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair. ACS APPLIED MATERIALS & INTERFACES, 13(47), 55767–55779. https://doi.org/10.1021/acsami.1c08044

Hu, S., Qiao, L., & Cheng, K. (2021). Generation and Manipulation of Exosomes. CARDIAC REGENERATION, Vol. 2158, pp. 295–305. https://doi.org/10.1007/978-1-0716-0668-1_22

Allen, T. A., & Cheng, K. (2021). Imaging and Isolation of Extravasation-Participating Endothelial and Melanoma Cells During Angiopellosis. MELANOMA, Vol. 2265, pp. 417–425. https://doi.org/10.1007/978-1-0716-1205-7_30

Li, Z., Zhu, D., Hui, Q., Bi, J., Yu, B., Huang, Z., … Wang, X. (2021). Injection of ROS-Responsive Hydrogel Loaded with Basic Fibroblast Growth Factor into the Pericardial Cavity for Heart Repair. ADVANCED FUNCTIONAL MATERIALS, 31(15). https://doi.org/10.1002/adfm.202004377

Zhu, D., Li, Z., Huang, K., Caranasos, T. G., Rossi, J. S., & Cheng, K. (2021). Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair. NATURE COMMUNICATIONS, 12(1). https://doi.org/10.1038/s41467-021-21682-7

Hu, S., Wang, X., Li, Z., Zhu, D., Cores, J., Wang, Z., … Cheng, K. (2021). Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury. NANO TODAY, 39. https://doi.org/10.1016/j.nantod.2021.101210

Hsu, Y., Huang, K., & Cheng, K. (2021). Resuscitating the Field of Cardiac Regeneration: Seeking Answers from Basic Biology. Advanced Biology, 6(2), 2101133. https://doi.org/10.1002/adbi.202101133

Zheng, P., Fan, M., Liu, H., Zhang, Y., Dai, X., Li, H., … Li, Z. (2021). Self-Propelled and Near-Infrared-Phototaxic Photosynthetic Bacteria as Photothermal Agents for Hypoxia-Targeted Cancer Therapy. ACS NANO, 15(1), 1100–1110. https://doi.org/10.1021/acsnano.0c08068

Cheng, X., & Cheng, K. (2021). [Review of Visualizing cancer extravasation: from mechanistic studies to drug development]. CANCER AND METASTASIS REVIEWS, 40(1), 71–88. https://doi.org/10.1007/s10555-020-09942-2

Mahgoub, E. O., Razmara, E., Bitaraf, A., Norouzi, F.-S., Montazeri, M., Behzadi-Andouhjerdi, R., … Babashah, S. (2020). [Review of Advances of exosome isolation techniques in lung cancer]. MOLECULAR BIOLOGY REPORTS, 47(9), 7229–7251. https://doi.org/10.1007/s11033-020-05715-w

Huang, P., Wang, L., Li, Q., Tian, X., Xu, J., Xu, J., … Yang, Y. (2020). Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA H19. CARDIOVASCULAR RESEARCH, 116(2), 353–367. https://doi.org/10.1093/cvr/cvz139

Su, T., Huang, K., Mathews, K. G., Scharf, V. F., Hu, S., Li, Z., … Cheng, K. (2020). Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs. ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(11), 6309–6320. https://doi.org/10.1021/acsbiomaterials.0c00942

Hu, S., Li, Z., Lutz, H., Huang, K., Su, T., Cores, J., … Cheng, K. (2020). Dermal exosomes containing miR-218-5p promote hair regeneration by regulating beta-catenin signaling. SCIENCE ADVANCES, 6(30). https://doi.org/10.1126/sciadv.aba1685

Li, J., Hu, S., & Cheng, K. (2020). [Review of Engineering better stem cell therapies for treating heart diseases]. ANNALS OF TRANSLATIONAL MEDICINE, 8(8). https://doi.org/10.21037/atm.2020.03.44

Popowski, K., Lutz, H., Hu, S., George, A., Dinh, P.-U., & Cheng, K. (2020). [Review of Exosome therapeutics for lung regenerative medicine]. JOURNAL OF EXTRACELLULAR VESICLES, 9(1). https://doi.org/10.1080/20013078.2020.1785161

Dinh, P.-U. C., Paudel, D., Brochu, H., Popowski, K. D., Gracieux, M. C., Cores, J., … Cheng, K. (2020). Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis. NATURE COMMUNICATIONS, 11(1). https://doi.org/10.1038/s41467-020-14344-7

Liang, H., Li, Z., Ren, Z., Jia, Q., Guo, L., Li, S., … Cheng, K. (2020). Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis. NANO RESEARCH, 13(8), 2197–2202. https://doi.org/10.1007/s12274-020-2833-6

Mei, X., & Cheng, K. (2020). [Review of Recent Development in Therapeutic Cardiac Patches]. FRONTIERS IN CARDIOVASCULAR MEDICINE, 7. https://doi.org/10.3389/fcvm.2020.610364

Li, Z., Hu, S., Huang, K., Su, T., Cores, J., & Cheng, K. (2020). Targeted anti-IL-1 beta platelet microparticles for cardiac detoxing and repair. SCIENCE ADVANCES, 6(6). https://doi.org/10.1126/sciadv.aay0589

Qiao, L., Hu, S., Huang, K., Su, T., Li, Z., Vandergriff, A., … Cheng, K. (2020). Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs. THERANOSTICS, 10(8), 3474–3487. https://doi.org/10.7150/thno.39434

Shen, D., Li, Z., Hu, S., Huang, K., Su, T., Liang, H., … Cheng, K. (2019). Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells. NANO LETTERS, 19(3), 1883–1891. https://doi.org/10.1021/acs.nanolett.8b04970

Su, T., Huang, K., Ma, H., Liang, H., Dinh, P.-U., Chen, J., … Cheng, K. (2019). Biomimetics: Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury (Adv. Funct. Mater. 4/2019). Advanced Functional Materials, 29(4), 1970019. https://doi.org/10.1002/ADFM.201970019

Huang, K., Li, Z., Su, T., Shen, D., Hu, S., & Cheng, K. (2019). Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells. ADVANCED THERAPEUTICS, 2(10). https://doi.org/10.1002/adtp.201900009

Liu, F., Hu, S., Wang, S., & Cheng, K. (2019). [Review of Cell and biomaterial-based approaches to uterus regeneration]. REGENERATIVE BIOMATERIALS, 6(3), 141–148. https://doi.org/10.1093/rb/rbz021

Li, Z., Hu, S., & Cheng, K. (2019). [Review of Chemical Engineering of Cell Therapy for Heart Diseases]. ACCOUNTS OF CHEMICAL RESEARCH, 52(6), 1687–1696. https://doi.org/10.1021/acs.accounts.9b00137

Berry, J. L., Zhu, W., Tang, Y. L., Krishnamurthy, P., Ge, Y., Cooke, J. P., … Zhang, J. (2019). [Review of Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure]. CIRCULATION RESEARCH, 124(1), 161–169. https://doi.org/10.1161/CIRCRESAHA.118.314216

Liu, F., Hu, S., Yang, H., Li, Z., Huang, K., Su, T., … Cheng, K. (2019). Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome. ADVANCED HEALTHCARE MATERIALS, 8(14). https://doi.org/10.1002/adhm.201900411

Hu, S., Li, Z., Cores, J., Huang, K., Su, T., Dinh, P.-U., & Cheng, K. (2019). Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging. ACS NANO, 13(10), 11273–11282. https://doi.org/10.1021/acsnano.9b04384

Su, T., Huang, K., Ma, H., Liang, H., Dinh, P.-U., Chen, J., … Cheng, K. (2019). Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury. ADVANCED FUNCTIONAL MATERIALS, 29(4). https://doi.org/10.1002/adfm.201803567

Li, Z., Feng, X., Gao, S., Jin, Y., Zhao, W., Liu, H., … Zhang, J. (2019). Porous Organic Polymer-Coated Band-Aids for Phototherapy of Bacteria-Induced Wound Infection. ACS Applied Bio Materials, 2(2), 613–618. https://doi.org/10.1021/ACSABM.8B00676

Qiao, L., Hu, S., Liu, S., Zhang, H., Ma, H., Huang, K., … Cheng, K. (2019). microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential. JOURNAL OF CLINICAL INVESTIGATION, 129(6), 2237–2250. https://doi.org/10.1172/JCI123135

Huang, K., Hu, S., & Cheng, K. (2018). A New Era of Cardiac Cell Therapy: Opportunities and Challenges. Advanced Healthcare Materials, 8(2), 1801011. https://doi.org/10.1002/adhm.201801011

Hu, S., Ogle, B. M., & Cheng, K. (2018). [Review of Body builder: from synthetic cells to engineered tissues]. CURRENT OPINION IN CELL BIOLOGY, 54, 37–42. https://doi.org/10.1016/j.ceb.2018.04.010

Su, T., Huang, K., Daniele, M. A., Hensley, M. T., Young, A. T., Tang, J., … Cheng, K. (2018). Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction. ACS APPLIED MATERIALS & INTERFACES, 10(39), 33088–33096. https://doi.org/10.1021/acsami.8b13571

Tang, J., Wang, J., Huang, K., Ye, Y., Su, T., Qiao, L., … Cheng, K. (2018). Cardiac cell-integrated microneedle patch for treating myocardial infarction. SCIENCE ADVANCES, 4(11). https://doi.org/10.1126/sciadv.aat9365

Tang, J.-N., Cores, J., Huang, K., Cui, X.-L., Luo, L., Zhang, J.-Y., … Cheng, K. (2018). Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future. Stem Cells Translational Medicine, 7(4), 354–359. https://doi.org/10.1002/sctm.17-0196

Hu, Q., Sun, W., Wang, J., Ruan, H., Zhang, X., Ye, Y., … Gu, Z. (2018). Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy. NATURE BIOMEDICAL ENGINEERING, 2(11), 831–840. https://doi.org/10.1038/s41551-018-0310-2

Liang, H., Huang, K., Su, T., Li, Z., Hu, S., Dinh, P.-U., … Cheng, K. (2018). Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure. ACS Nano, 12(7), 6536–6544. https://doi.org/10.1021/ACSNANO.8B00553

Allen, T., Amu, E., Asad, D., & Cheng, K. (2018, July). Metastatic melanoma and cervical tumor cell clusters can exit blood vessels through angiopellosis augmenting tumor formation ability. CANCER RESEARCH, Vol. 78. https://doi.org/10.1158/1538-7445.AM2018-90

Cui, X., Tang, J., Hartanto, Y., Zhang, J., Bi, J., Dai, S., … Zhang, H. (2018). NIPAM-based Microgel Microenvironment Regulates the Therapeutic Function of Cardiac Stromal Cells. ACS APPLIED MATERIALS & INTERFACES, 10(44), 37783–37796. https://doi.org/10.1021/acsami.8b09757

Li, Z., Hu, S., & Cheng, K. (2018). [Review of Platelets and their biomimetics for regenerative medicine and cancer therapies]. JOURNAL OF MATERIALS CHEMISTRY B, 6(45), 7354–7365. https://doi.org/10.1039/c8tb02301h

Li, Z., Shen, D., Hu, S., Su, T., Huang, K., Liu, F., … Cheng, K. (2018). Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair. ACS NANO, 12(12), 12193–12200. https://doi.org/10.1021/acsnano.8b05892

Mihalko, E., Huang, K., Sproul, E., Cheng, K., & Brown, A. C. (2018). Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic. ACS Nano, 12(8), 7826–7837. https://doi.org/10.1021/ACSNANO.8B01977

Tang, J., Su, T., Huang, K., Dinh, P.-U., Wang, Z., Vandergriff, A., … Cheng, K. (2018). Targeted repair of heart injury by stem cells fused with platelet nanovesicles. NATURE BIOMEDICAL ENGINEERING, 2(1), 17–26. https://doi.org/10.1038/s41551-017-0182-x

Vandergriff, A., Huang, K., Shen, D., Hu, S., Hensley, M. T., Caranasos, T. G., … Cheng, K. (2018). Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide. THERANOSTICS, 8(7), 1869–1878. https://doi.org/10.7150/thno.20524

Tang, J., Vandergriff, A., Wang, Z., Hensley, M. T., Cores, J., Allen, T. A., … Cheng, K. (2017). A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart. Tissue Engineering Part C: Methods, 23(3), 146–155. https://doi.org/10.1089/ten.tec.2016.0492

Dinh, P.-U. C., Cores, J., Hensley, M. T., Vandergriff, A. C., Tang, J., Allen, T. A., … Cheng, K. (2017). Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies. Respiratory Research, 18(1). https://doi.org/10.1186/s12931-017-0611-0

Luo, L., Tang, J., Nishi, K., Yan, C., Dinh, P.-U., Cores, J., … Cheng, K. (2017). Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice. Circulation Research, 120(11), 1768–1775. https://doi.org/10.1161/circresaha.116.310374

Tang, J., Cui, X., Caranasos, T. G., Hensley, M. T., Vandergriff, A. C., Hartanto, Y., … Cheng, K. (2017). Heart Repair Using Nanogel-Encapsulated Human Cardiac Stem Cells in Mice and Pigs with Myocardial Infarction. ACS NANO, 11(10), 9738–9749. https://doi.org/10.1021/acsnano.7b01008

Hensley, M. T., Tang, J., Woodruff, K., Defrancesco, T., Tou, S., Williams, C. M., … al. (2017). Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy. Journal of Cellular and Molecular Medicine, 21(8), 1503–1512. https://doi.org/10.1111/jcmm.13077

Fagg, W. S., Liu, N., Yang, M.-J., Cheng, K., Chung, E., Kim, J.-S., … Fair, J. (2017). Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver. Cell Transplantation, 26(12), 1868–1877. https://doi.org/10.1177/0963689717737320

Cores, J., Hensley, M. T., Kinlaw, K., Rikard, S. M., Dinh, P.-U., Paudel, D., … Cheng, K. (2017). Safety and Efficacy of Allogeneic Lung Spheroid Cells in a Mismatched Rat Model of Pulmonary Fibrosis. STEM CELLS Translational Medicine, 6(10), 1905–1916. https://doi.org/10.1002/sctm.16-0374

Tang, J., Shen, D., Caranasos, T. G., Wang, Z., Vandergriff, A. C., Allen, T. A., … Cheng, K. (2017). Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome. Nature Communications, 8(1). https://doi.org/10.1038/ncomms13724

Wang, Z., Dong, N., Niu, Y., Zhang, Z., Zhang, C., Liu, M., … Cheng, K. (2017). Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 21(10), 2432–2440. https://doi.org/10.1111/jcmm.13165

Allen, T. A., Gracieux, D., Talib, M., Tokarz, D. A., Hensley, M. T., Cores, J., … Cheng, K. (2016). Angiopellosis as an Alternative Mechanism of Cell Extravasation. STEM CELLS, 35(1), 170–180. https://doi.org/10.1002/stem.2451

Shen, D., Tang, J., Hensley, M. T., Li, T., Caranasos, T. G., Zhang, T., … Cheng, K. (2016). Effects of Matrix Metalloproteinases on the Performance of Platelet Fibrin Gel Spiked With Cardiac Stem Cells in Heart Repair. STEM CELLS TRANSLATIONAL MEDICINE, 5(6), 793–803. https://doi.org/10.5966/sctm.2015-0194

Henry, E., Cores, J., Hensley, M. T., Anthony, S., Vandergriff, A., Andrade, J. B. M., … Cheng, K. (2015). Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents With Bleomycin-Induced Pulmonary Fibrosis. STEM CELLS TRANSLATIONAL MEDICINE, 4(11), 1265–1274. https://doi.org/10.5966/sctm.2015-0062

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Vandergriff, A. C., de Andrade, J. B. M., Tang, J., Hensley, M. T., Piedrahita, J. A., Caranasos, T. G., & Cheng, K. (2015). Intravenous Cardiac Stem Cell-Derived Exosomes Ameliorate Cardiac Dysfunction in Doxorubicin Induced Dilated Cardiomyopathy. Stem Cells International, 2015, 1–8. https://doi.org/10.1155/2015/960926

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Andrade, J. N. B. M., Tang, J., Hensley, M. T., Vandergriff, A., Cores, J., Henry, E., … Cheng, K. (2015). Rapid and Efficient Production of Coronary Artery Ligation and Myocardial Infarction in Mice Using Surgical Clips. PLOS ONE, 10(11). https://doi.org/10.1371/journal.pone.0143221

Yee, K., Malliaras, K., Kanazawa, H., Tseliou, E., Cheng, K., Luthringer, D. J., … Marban, E. (2014). Allogeneic Cardiospheres Delivered via Percutaneous Transendocardial Injection Increase Viable Myocardium, Decrease Scar Size, and Attenuate Cardiac Dilatation in Porcine Ischemic Cardiomyopathy. PLOS ONE, 9(12). https://doi.org/10.1371/journal.pone.0113805

Cheng, K., Ibrahim, A., Hensley, M. T., Sun, B., Liu, W., Smith, R. R., & Marban, E. (2014). CD90/Thy-1-negative cardiosphere-derived cells exhibit augmented regenerative potency in humans and mice with myocardial infarction. Journal of the American Heart Association, 3(5), 001260.

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Cingolani, E., Ionta, V., Cheng, K., Giacomello, A., Cho, H. C., & Marbán, E. (2014). Engineered Electrical Conduction Tract Restores Conduction in Complete Heart Block. Journal of the American College of Cardiology, 64(24), 2575–2585. https://doi.org/10.1016/j.jacc.2014.09.056

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Cheng, K., Malliaras, K., Smith, R. R., Shen, D., Sun, B., Blusztajn, A., … Marbán, E. (2014). Human Cardiosphere-Derived Cells From Advanced Heart Failure Patients Exhibit Augmented Functional Potency in Myocardial Repair. JACC: Heart Failure, 2(1), 49–61. https://doi.org/10.1016/j.jchf.2013.08.008

Xie, Y., Ibrahim, A., Cheng, K., Wu, Z., Liang, W., Malliaras, K., … Marbán, E. (2014). Importance of Cell-Cell Contact in the Therapeutic Benefits of Cardiosphere-Derived Cells. STEM CELLS, 32(9), 2397–2406. https://doi.org/10.1002/STEM.1736

Malliaras, K., Makkar, R. R., Smith, R. R., Cheng, K., Wu, E., Bonow, R. O., … Marbán, E. (2014). Intracoronary Cardiosphere-Derived Cells After Myocardial Infarction. Journal of the American College of Cardiology, 63(2), 110–122. https://doi.org/10.1016/j.jacc.2013.08.724

Cheng, K., Shen, D., Hensley, M. T., Middleton, R., Sun, B., Liu, W., … Marbán, E. (2014). Magnetic antibody-linked nanomatchmakers for therapeutic cell targeting. Nature Communications, 5(1). https://doi.org/10.1038/ncomms5880

Vandergriff, A. C., Hensley, T. M., Henry, E. T., Shen, D., Anthony, S., Zhang, J., & Cheng, K. (2014). Magnetic targeting of cardiosphere-derived stem cells with ferumoxytol nanoparticles for treating rats with myocardial infarction. BIOMATERIALS, 35(30), 8528–8539. https://doi.org/10.1016/j.biomaterials.2014.06.031

Cheng, K., Ibrahim, A., Hensley, M. T., Shen, D., Sun, B., Middleton, R., … Marban, E. (2014). Relative Roles of CD90 and c-Kit to the Regenerative Efficacy of Cardiosphere-Derived Cells in Humans and in a Mouse Model of Myocardial Infarction. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 3(5). https://doi.org/10.1161/jaha.114.001260

Aminzadeh, M. A., Tseliou, E., Sun, B., Cheng, K., Malliaras, K., Makkar, R. R., & Marban, E. (2014). Therapeutic efficacy of cardiosphere-derived cells in a transgenic mouse model of non-ischaemic dilated cardiomyopathy. European Heart Journal, 36(12), 751–762. https://doi.org/10.1093/eurheartj/ehu196

Malliaras, K., Zhang, Y., Seinfeld, J., Galang, G., Tseliou, E., Cheng, K., … Marbán, E. (2013). Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart. EMBO Molecular Medicine, 5(2), 191–209. https://doi.org/10.1002/emmm.201201737

Malliaras, K., Cheng, K., Smith, R. R., Wu, E., Bonow, R., Mendizabal, A., … Marbán, E. (2013). INTRACORONARY CARDIOSPHERE-DERIVED CELLS AFTER MYOCARDIAL INFARCTION: MAGNETIC RESONANCE IMAGING ANALYSIS OF REGENERATION AND DETERMINANTS OF EFFICACY IN THE FINAL 1-YEAR RESULTS OF THE CADUCEUS TRIAL. Journal of the American College of Cardiology, 61(10), E104. https://doi.org/10.1016/S0735-1097(13)60105-9

Malliaras, K., Smith, R. R., Kanazawa, H., Yee, K., Seinfeld, J., Tseliou, E., … Marbán, E. (2013). Validation of Contrast-Enhanced Magnetic Resonance Imaging to Monitor Regenerative Efficacy After Cell Therapy in a Porcine Model of Convalescent Myocardial Infarction. Circulation, 128(25), 2764–2775. https://doi.org/10.1161/circulationaha.113.002863

Cheng, K., Shen, D., Xie, Y., Cingolani, E., Malliaras, K., & Marbán, E. (2012). Brief Report: Mechanism of Extravasation of Infused Stem Cells. STEM CELLS, 30(12), 2835–2842. https://doi.org/10.1002/stem.1184

Li, T.-S., Cheng, K., Malliaras, K., Smith, R. R., Zhang, Y., Sun, B., … Marbán, E. (2012). Direct Comparison of Different Stem Cell Types and Subpopulations Reveals Superior Paracrine Potency and Myocardial Repair Efficacy With Cardiosphere-Derived Cells. Journal of the American College of Cardiology, 59(10), 942–953. https://doi.org/10.1016/j.jacc.2011.11.029

Shen, D., Cheng, K., & Marbán, E. (2012). Dose-dependent functional benefit of human cardiosphere transplantation in mice with acute myocardial infarction. Journal of Cellular and Molecular Medicine, 16(9), 2112–2116. https://doi.org/10.1111/j.1582-4934.2011.01512.x

Cheng, K., Blusztajn, A., Shen, D., Li, T.-S., Sun, B., Galang, G., … Marbán, L. (2012). Functional performance of human cardiosphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydrogel. Biomaterials, 33(21), 5317–5324. https://doi.org/10.1016/j.biomaterials.2012.04.006

Makkar, R. R., Smith, R. R., Cheng, K., Malliaras, K., Thomson, L. E. J., Berman, D., … Marbán, E. (2012). Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. The Lancet, 379(9819), 895–904. https://doi.org/10.1016/s0140-6736(12)60195-0

Cheng, K., Malliaras, K., Shen, D., Tseliou, E., Ionta, V., Smith, J., … Marbán, E. (2012). Intramyocardial Injection of Platelet Gel Promotes Endogenous Repair and Augments Cardiac Function in Rats With Myocardial Infarction. Journal of the American College of Cardiology, 59(3), 256–264. https://doi.org/10.1016/j.jacc.2011.10.858

Malliaras, K., Li, T.-S., Luthringer, D., Terrovitis, J., Cheng, K., Chakravarty, T., … Marbán, E. (2012). Safety and Efficacy of Allogeneic Cell Therapy in Infarcted Rats Transplanted With Mismatched Cardiosphere-Derived Cells. Circulation, 125(1), 100–112. https://doi.org/10.1161/circulationaha.111.042598

Lai, Y., Cheng, K., & Kisaalita, W. (2012). Three Dimensional Neuronal Cell Cultures More Accurately Model Voltage Gated Calcium Channel Functionality in Freshly Dissected Nerve Tissue. PLoS ONE, 7(9), e45074. https://doi.org/10.1371/journal.pone.0045074

Cheng, K., Shen, D., Smith, J., Galang, G., Sun, B., Zhang, J., & Marbán, E. (2012). Transplantation of platelet gel spiked with cardiosphere-derived cells boosts structural and functional benefits relative to gel transplantation alone in rats with myocardial infarction. Biomaterials, 33(10), 2872–2879. https://doi.org/10.1016/j.biomaterials.2011.12.040

Lai, Y., Asthana, A., Cheng, K., & Kisaalita, W. S. (2011). Neural Cell 3D Microtissue Formation Is Marked by Cytokines' Up-Regulation. PLoS ONE, 6(10), e26821. https://doi.org/10.1371/journal.pone.0026821

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Li, T.-S., Cheng, K., Lee, S.-T., Matsushita, S., Davis, D., Malliaras, K., … Marbán, E. (2010). Cardiospheres Recapitulate a Niche-Like Microenvironment Rich in Stemness and Cell-Matrix Interactions, Rationalizing Their Enhanced Functional Potency for Myocardial Repair. STEM CELLS, 28(11), 2088–2098. https://doi.org/10.1002/stem.532

Zhang, Y., Li, T.-S., Lee, S.-T., Wawrowsky, K. A., Cheng, K., Galang, G., … Marbán, E. (2010). Dedifferentiation and Proliferation of Mammalian Cardiomyocytes. PLoS ONE, 5(9), e12559. https://doi.org/10.1371/journal.pone.0012559

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Cheng, K., Li, T.-S., Malliaras, K., Davis, D. R., Zhang, Y., & Marbán Eduardo. (2010). Magnetic Targeting Enhances Engraftment and Functional Benefit of Iron-Labeled Cardiosphere-Derived Cells in Myocardial Infarction. Circulation Research, 106(10), 1570–1581. https://doi.org/10.1161/circresaha.109.212589

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