Kristen Bagley

Works (3)

Updated: July 5th, 2023 15:36

2021 article

Single-minded 2 is required for left-right asymmetric stomach morphogenesis

Wyatt, B. H., Amin, N. M., Bagley, K., Wcisel, D. J., Dush, M. K., Yoder, J. A., & Nascone-Yoder, N. M. (2021, July 1). Development, Vol. 9.

By: B. Wyatt n, N. Amin n, K. Bagley n, D. Wcisel n, M. Dush n, J. Yoder n , N. Nascone-Yoder n 

author keywords: right asymmetry; Stomach; Morphogenesis; Pitx2; Sim2; Down syndrome; Frog
MeSH headings : Animals; Anura; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Body Patterning; Embryo, Nonmammalian; Endoderm / embryology; Endoderm / metabolism; Gene Expression Regulation, Developmental; Homeodomain Proteins / genetics; Homeodomain Proteins / metabolism; Morphogenesis; Stomach / embryology; Transcription Factors / genetics; Transcription Factors / metabolism
topics (OpenAlex): Congenital heart defects research; Developmental Biology and Gene Regulation
TL;DR: It is demonstrated that sim2 functions downstream of LR patterning cues to regulate key cellular properties and behaviors in the left stomach epithelium that drive asymmetric curvature, and has implications for dose-dependent roles of laterality factors in non-laterality-related birth defects. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021

2017 article

Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity

Pohl, C. S., Medland, J. E., Mackey, E., Edwards, L. L., Bagley, K. D., DeWilde, M. P., … Moeser, A. J. (2017, June 1). Neurogastroenterology & Motility, Vol. 29.

By: C. Pohl*, J. Medland n, E. Mackey n, L. Edwards n , K. Bagley n, M. DeWilde*, K. Williams*, A. Moeser *

author keywords: developmental origins of health and disease; early life adversity; intestinal permeability; large animal model; mast cell; mast cell plexitis; translational research
MeSH headings : Animals; Cell Count; Colon / pathology; Diarrhea / etiology; Disease Models, Animal; Enteric Nervous System / pathology; Female; Ileum / metabolism; Ileum / pathology; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Intestinal Mucosa / physiopathology; Intestines / pathology; Intestines / physiopathology; Male; Mast Cells / metabolism; Mast Cells / physiology; Stress, Psychological / complications; Sus scrofa; Tryptases / metabolism; Weaning
topics (OpenAlex): Animal Behavior and Welfare Studies; Gastrointestinal motility and disorders; Dermatology and Skin Diseases
TL;DR: Early life adversity is a risk factor for development of gastrointestinal disorders later in life and the underlying mechanisms through which ELA and sex interact to influence disease susceptibility remains poorly understood. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 article

Stomach curvature is generated by left-right asymmetric gut morphogenesis

Davis, A., Amin, N. M., Johnson, C., Bagley, K., Ghashghaei, H. T., & Nascone-Yoder, N. (2017, February 27). Development, Vol. 144, pp. 1477–1483.

By: A. Davis n, N. Amin n, C. Johnson n, K. Bagley n, H. Ghashghaei n & N. Nascone-Yoder n 

author keywords: Left-right; Asymmetry; Stomach; Gut; Morphogenesis; Pitx2; Xenopus; Mouse
MeSH headings : Animals; Body Patterning; Endoderm / embryology; Endoderm / metabolism; Epithelium / embryology; Epithelium / metabolism; Homeodomain Proteins / metabolism; Mice; Rotation; Signal Transduction; Stomach / anatomy & histology; Stomach / embryology; Transcription Factors / metabolism; Xenopus / embryology
topics (OpenAlex): Congenital heart defects research; Digestive system and related health; Developmental Biology and Gene Regulation
TL;DR: It is shown that the mechanisms that drive the curvature of the stomach are intrinsic to the gut tube itself, and this findings have implications for how LR patterning manifests distinct types of morphological asymmetries in different contexts. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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