Works (16)

Updated: April 10th, 2024 05:00

2024 article

Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity

Liu, M., Hu, S., Yan, N., Popowski, K. D., & Cheng, K. (2024, January 11). NATURE NANOTECHNOLOGY, Vol. 1.

By: M. Liu*, S. Hu*, N. Yan*, K. Popowski n & K. Cheng*

TL;DR: The delivery of IL-12 mRNA encapsulated in extracellular vesicles to lungs via inhalation is reported on and the immunotherapeutic potential of targeted cytokine mRNA therapy is demonstrated, showing the potential for locally delivered cytokine-based immunotherapies to address orthotopic and metastatic lung tumours. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID
Added: January 29, 2024

2024 journal article

Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2

NATURE COMMUNICATIONS, 15(1).

By: Z. Wang n, S. Hu*, K. Popowski n, S. Liu*, D. Zhu*, X. Mei n, J. Li*, Y. Hu* ...

Sources: Web Of Science, ORCID
Added: April 8, 2024

2023 journal article

An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection

Nature Materials, 2.

By: X. Mei n, J. Li n, Z. Wang n, D. Zhu n, K. Huang n, S. Hu n, K. Popowski n, K. Cheng

TL;DR: A physical barrier against SARS-CoV-2 infection based on an inhalable bioadhesive hydrogel, named spherical hydrogels inhalation for enhanced lung defence (SHIELD), which is conveniently delivered via a dry powder inhaler and made with food-grade materials and does not affect normal respiratory functions. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: March 6, 2023

2023 journal article

Tissue clearing and three-dimensional imaging of the whole cochlea and vestibular system from multiple large-animal models

STAR PROTOCOLS, 4(2).

By: A. Moatti n, Y. Cai n, C. Li n, K. Popowski n, K. Cheng n, F. Ligler*, A. Greenbaum n

author keywords: imaged cochleae using open -source software.; several mm; larger animal inner; open -source software
TL;DR: A protocol that enables three-dimensional (3D) characterization of intact inner ears from large-animal models is presented and a pipeline to count hair cells in antibody-stained and 3D imaged cochleae using open-source software is detailed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: September 5, 2023

2022 article

Decoy Exosomes Offer Protection Against Chemotherapy-Induced Toxicity

Fan, M., Li, H., Shen, D., Wang, Z., Liu, H., Zhu, D., … Li, Z. (2022, September 4). ADVANCED SCIENCE, Vol. 9.

By: M. Fan*, H. Li*, D. Shen*, Z. Wang*, H. Liu*, D. Zhu n, Z. Wang n, L. Li* ...

author keywords: cardio-oncology; cardiotoxicity; chemotherapy; exosome; tetrahedral DNA nanostructure
MeSH headings : Humans; Exosomes / genetics; Exosomes / metabolism; Cardiotoxicity / etiology; Cardiotoxicity / prevention & control; Cardiotoxicity / metabolism; Quality of Life; Neoplasms; Antineoplastic Agents / toxicity; Antineoplastic Agents / metabolism; Chemical and Drug Induced Liver Injury / metabolism
TL;DR: This decoy exosome strategy serves as a promising therapy to reduce chemo‐induced toxicity and can also promote macrophage polarization into the M2 type for tissue repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: September 12, 2022

2022 article

Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine

Wang, Z., Popowski, K. D., Zhu, D., Abad, B. L. de J., Wang, X., Liu, M., … Cheng, K. (2022, July 4). NATURE BIOMEDICAL ENGINEERING, Vol. 7.

By: Z. Wang n, K. Popowski n, D. Zhu n, B. Abad n, X. Wang n, M. Liu n, H. Lutz n, N. De Naeyer* ...

MeSH headings : Animals; Antibodies, Neutralizing; CD8-Positive T-Lymphocytes; COVID-19 / prevention & control; COVID-19 Vaccines; Exosomes; Humans; Mice; Mice, Inbred BALB C; SARS-CoV-2; Viral Vaccines
TL;DR: The design and preclinical testing of an inhalable virus-like-particle as a COVID-19 vaccine that, after lyophilisation, is stable at room temperature for over three months and elicits systemic and mucosal immune responses in small animals is reported. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: July 11, 2022

2022 journal article

Inhalable dry powder mRNA vaccines based on extracellular vesicles

Matter, 5(9), 2960–2974.

By: K. Popowski n, A. Moatti n, G. Scull n, D. Silkstone n, H. Lutz n, B. López de Juan Abad n, A. George n, E. Belcher n ...

TL;DR: The results suggest that extracellular vesicles can serve as an inhaled mRNA drug-delivery system that is superior to synthetic liposomes. (via Semantic Scholar)
Sources: Web Of Science, ORCID, Crossref
Added: October 17, 2022

2022 journal article

Inhalable exosomes outperform liposomes as mRNA and protein drug carriers to the lung

Extracellular Vesicle.

By: K. Popowski n, B. Juan Abad n, A. George n, D. Silkstone n, E. Belcher n, J. Chung n, A. Ghodsi n, H. Lutz n ...

TL;DR: Inhaled Lung-Exo can deliver mRNA and protein drugs with enhanced pulmonary bioavailability and therapeutic efficacy, and is compared against commercially standard biological extracellular vesicles (HEK-ExO) and LNPs (Lipo), where Lung- exo exhibited superior mRNA andprotein cargo distribution to and retention in the bronchioles and parenchyma following nebulization administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: June 16, 2022

2022 journal article

Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction

CHEMICAL ENGINEERING JOURNAL, 427.

By: J. Li n, Y. Lv*, D. Zhu n, X. Mei n, K. Huang n, X. Wang n, Z. Li n, S. Zhang n ...

Contributors: J. Li n, Y. Lv*, D. Zhu n, X. Mei n, K. Huang n, X. Wang n, Z. Li n, S. Zhang n ...

author keywords: Mesenchymal stem cells; Hydrogel; Myocardial infarction; Intrapericardial; Intramyocardial
TL;DR: Intrapericardial cavity injection gave a promising solution for the low retention issue of MSCs in the infarcted heart and the feasibility and safety of IPC injection were demonstrated in a porcine model with minimally invasive procedure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: January 3, 2022

2021 journal article

Advanced Nanobiomedical Approaches to Combat Coronavirus Disease of 2019

Advanced NanoBiomed Research, 1(3), 2000063.

By: H. Lutz n, K. Popowski n, P. Dinh n & K. Cheng n

author keywords: coronavirus disease; exosomes; nanomedicine; severe acute respiratory syndrome coronavirus 2; therapeutics; vaccines
TL;DR: A review of nanobiomedical techniques for combatting COVID‐19 in terms of vaccines and therapeutics finds some vaccine candidates of key interest are whole inactivated viruses, adeno‐associated viruses, virus‐like particles, and lipid nanoparticles. (via Semantic Scholar)
Source: ORCID
Added: June 8, 2022

2021 journal article

Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19

Nature Nanotechnology, 6(8), 942–951.

By: Z. Li n, Z. Wang n, P. Dinh n, D. Zhu n, K. Popowski n, H. Lutz n, S. Hu n, M. Lewis* ...

Contributors: Z. Li n, Z. Wang n, P. Dinh n, D. Zhu n, K. Popowski n, H. Lutz n, S. Hu n, M. Lewis* ...

MeSH headings : Administration, Inhalation; Angiotensin-Converting Enzyme 2 / metabolism; Animals; COVID-19 / virology; Cell-Derived Microparticles / metabolism; Cell-Derived Microparticles / transplantation; Disease Models, Animal; Humans; Lung Injury / prevention & control; Lung Injury / virology; Macaca fascicularis; Mice; Nanostructures / administration & dosage; Protein Binding; SARS-CoV-2 / drug effects; SARS-CoV-2 / metabolism; Spheroids, Cellular / metabolism; Spike Glycoprotein, Coronavirus / metabolism; Viral Load / drug effects; COVID-19 Drug Treatment
TL;DR: It is shown that nanovesicles coated with lung spheroid cell membranes expressing angiotensin-converting enzyme 2 can bind the spike protein of SARS-CoV-2, neutralizing the virus and preventing lung cell infections in murine and non-human primate models. (via Semantic Scholar)
Source: ORCID
Added: June 18, 2021

2021 article

Enhancement of Bone Regeneration Through the Converse Piezoelectric Effect, A Novel Approach for Applying Mechanical Stimulation

Carter, A., Popowski, K., Cheng, K., Greenbaum, A., Ligler, F. S., & Moatti, A. (2021, September 24). BIOELECTRICITY, Vol. 9.

By: A. Carter n, K. Popowski n, K. Cheng n, A. Greenbaum n, F. Ligler n & A. Moatti n

author keywords: converse piezoelectric effect; mechanical stimulation; bone regeneration
TL;DR: The potential of the converse piezoelectric effect to enhance bone regeneration is highlighted by discussing the activation of beneficial cellular pathways, the properties of piezOElectric biomaterials, and the potential for the more effective administration of the Converse pieZoelectrics effect using wireless control. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID
Added: September 25, 2021

2021 review

Exosome therapeutics for COVID-19 and respiratory viruses

[Review of ]. VIEW, 2(3).

By: K. Popowski n, P. Dinh n, A. George n, H. Lutz n & K. Cheng n

author keywords: COVID-19; exosomes; respiratory viruses; SARS-CoV-2
TL;DR: The relationship between exosomes and respiratory viruses is reviewed, potential exosome therapeutics for viral infections are described, and progress toward clinical translation for lung‐derived exosomal therapeutics is summarized. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: July 19, 2021

2020 journal article

Exosome and Biomimetic Nanoparticle Therapies for Cardiac Regenerative Medicine

Current Stem Cell Research & Therapy, 15(8), 674–684.

By: S. Stine n, K. Popowski n, T. Su n & K. Cheng n

author keywords: Exosomes; regenerative medicine; biomimetic nanoparticles; drug delivery; extracellular vesicles; mesenchymal stem cells; secretome
MeSH headings : Biomimetics; Exosomes; Heart Diseases / therapy; Nanoparticles; Regenerative Medicine; Reproducibility of Results
TL;DR: Current research on exosome therapeutics and the application of biomimetic nanoparticles in cardiac regenerative medicine, as well as applications for exosomes expansion and delivery on a larger and more clinical scale are summarized. (via Semantic Scholar)
Source: ORCID
Added: June 8, 2022

2020 review

Exosome therapeutics for lung regenerative medicine

[Review of ]. JOURNAL OF EXTRACELLULAR VESICLES, 9(1).

By: K. Popowski n, H. Lutz n, S. Hu n, A. George n, P. Dinh n & K. Cheng n

author keywords: Exosome; regenerative medicine; lung spheroid cell; stem cell
TL;DR: The uses of exosomes as a therapy and their roles in lung regenerative medicine, as well as current challenges in exosome therapies are underline. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID
Added: July 20, 2020

2020 journal article

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis

NATURE COMMUNICATIONS, 11(1).

By: P. Dinh n, D. Paudel n, H. Brochu n, K. Popowski n, M. Gracieux n, J. Cores n, K. Huang n, M. Hensley n ...

MeSH headings : Administration, Inhalation; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Alveolar Epithelial Cells / pathology; Animals; Apoptosis / drug effects; Bleomycin / toxicity; Cell Proliferation; Disease Models, Animal; Exosomes / metabolism; Exosomes / transplantation; Humans; Idiopathic Pulmonary Fibrosis / chemically induced; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Idiopathic Pulmonary Fibrosis / therapy; Lung / cytology; Lung / metabolism; Lung Injury / chemically induced; Lung Injury / metabolism; Lung Injury / pathology; Lung Injury / therapy; Mesenchymal Stem Cells / metabolism; Mice; Myofibroblasts / cytology; Proteomics; Silicon Dioxide / toxicity; Spheroids, Cellular / metabolism
TL;DR: It is shown that the secretome and exosomes of lung spheroid cells is effective as inhalation treatment in rodent models of lung injury and fibrosis and superior to the counterparts derived from mesenchymal stem cells. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: March 23, 2020

Employment

Updated: May 16th, 2023 15:35

2023 - present

Immorna Biotherapeutics Raleigh, US
Scientist

Education

Updated: May 16th, 2023 15:36

2018 - 2023

North Carolina State University Raleigh, North Carolina, US
PhD Comparative Biomedical Sciences

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