2014 journal article

A High-Temperature, High-Throughput Method for Monitoring Residual Formaldehyde in Vaccine Formulations

JALA, 19(3), 275–284.

By: K. Stallings n, R. Kitchener n & N. Hentz n

author keywords: vaccine; residual formaldehyde; formaldehyde assay; high-temperature assay
MeSH headings : Automation, Laboratory; Calibration; Carcinogens / analysis; Carcinogens / chemistry; Disinfectants / analysis; Disinfectants / chemistry; Drug Compounding; Drug Contamination / prevention & control; Drug Stability; Fluorescent Dyes / analysis; Fluorescent Dyes / chemistry; Formaldehyde / analysis; Formaldehyde / chemistry; High-Throughput Screening Assays; Hot Temperature; Hydralazine / chemistry; Hydrogen-Ion Concentration; Indicators and Reagents / chemistry; Influenza Vaccines / chemistry; Limit of Detection; Phthalazines / analysis; Phthalazines / chemistry; Quality Control; Reproducibility of Results; Spectrometry, Fluorescence; Triazoles / analysis; Triazoles / chemistry; Volatilization
TL;DR: An assay was developed that is capable of detecting levels of residual formaldehyde in influenza vaccine samples and has attained detection limits of 0.01 µg/mL residualformaldehyde, which is easily able to detect and quantify formaldehyde at levels used in many current vaccine formulations. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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