@article{cooks_duke_flood-grady_vilaro_ghosh_parker_te_george_lok_williams_et al._2022, title={Can virtual human clinicians help close the gap in colorectal cancer screening for rural adults in the United States? The influence of rural identity on perceptions of virtual human clinicians}, volume={30}, ISSN={["2211-3355"]}, DOI={10.1016/j.pmedr.2022.102034}, abstractNote={Rural adults experience disparities in colorectal cancer screening, a trend even more distinct among rural Black adults. Healthcare disruptions caused by COVID-19 exacerbated inequities, heightening attention on virtual communication strategies to increase screening. Yet little is known about how rural adults perceive virtual human clinicians (VHCs). Given that identifying as rural influences perceived source credibility often through appearance judgments, the goal of this pilot was to explore how to develop VHCs that individuals highly identified with rurality find attractive. Between November 2018 and April 2019, we tested a culturally tailored, VHC-led telehealth intervention delivering evidence-based colorectal cancer prevention education with White and Black adults (N = 2079) in the United States recruited through an online panel who were non-adherent to screening guidelines and between 50 and 73 years of age. Participants were randomized on three factors (VHC race-matching, VHC gender-matching, Intervention type). Ordinal logistic regression models examined VHC appearance ratings. Participants with a high rural identity (AOR = 1.12, CI = [1.02, 1.23], p =.02) rated the VHCs more attractive. High rural belonging influenced VHC attractiveness for Black participants (AOR = 1.22, CI = [1.03, 1.44], p =.02). Also, Black participants interacting with a Black VHC and reporting high rural self-concept rated the VHC as more attractive (AOR = 2.22, CI = [1.27, 3.91], p =.01). Findings suggest adults for whom rural identity is important have more positive impressions of VHC attractiveness. For patients with strong rural identities, enhancing VHC appearance is critical to tailoring colorectal cancer prevention interventions.}, journal={PREVENTIVE MEDICINE REPORTS}, author={Cooks, Eric J. and Duke, Kyle A. and Flood-Grady, Elizabeth and Vilaro, Melissa J. and Ghosh, Rashi and Parker, Naomi and Te, Palani and George, Thomas J. and Lok, Benjamin C. and Williams, Maribeth and et al.}, year={2022}, month={Dec} }
 @article{neil_parker_strekalova_duke_george_krieger_2022, title={Communicating risk to promote colorectal cancer screening: a multi-method study to test tailored versus targeted message strategies}, ISSN={["1465-3648"]}, DOI={10.1093/her/cyac002}, abstractNote={Abstract}, journal={HEALTH EDUCATION RESEARCH}, author={Neil, Jordan M. and Parker, Naomi D. and Strekalova, Yulia A. Levites and Duke, Kyle and George, Thomas and Krieger, Janice L.}, year={2022}, month={Mar} }
 @article{seifu_mt-isa_duke_gamalo-siebers_wang_dong_kolassa_2022, title={Design of paediatric trials with benefit-risk endpoints using a composite score of adverse events of interest (AEI) and win-statistics}, ISSN={["1520-5711"]}, DOI={10.1080/10543406.2022.2153202}, abstractNote={ABSTRACT A fundamental problem in the regulatory evaluation of a therapy is assessing whether the benefit outweighs the associated risks. This work proposes designing a trial that assesses a composite endpoint consisting of benefit and risk, hence, making the core of the design of the study, to assess benefit and risk. The proposed benefit risk measure consists of efficacy measure(s) and a risk measure that is based on a composite score obtained from pre-defined adverse events of interest (AEI). This composite score incorporates full aspects of adverse events of interest (i.e. the incidence, severity, and duration of the events). We call this newly proposed score the AEI composite score. After specifying the priorities between the components of the composite endpoint, a win-statistic (i.e. win ratio, win odds, or net benefit) is used to assess the difference between treatments in this composite endpoint. The power and sample size requirements of such a trial design are explored via simulation. Finally, using Dupixent published adult study results, we show how we can design a paediatric trial where the primary outcome is a composite of prioritized outcomes consisting of efficacy endpoints and the AEI composite score endpoint. The resulting trial design can potentially substantially reduce sample size compared to a trial designed to assess the co-primary efficacy endpoints, therefore it may address the challenge of slow enrollment and patient availability for paediatric studies.}, journal={JOURNAL OF BIOPHARMACEUTICAL STATISTICS}, author={Seifu, Yodit and Mt-Isa, Shahrul and Duke, Kyle and Gamalo-Siebers, Margaret and Wang, William and Dong, Gaohong and Kolassa, John}, year={2022}, month={Dec} }
 @article{cooks_duke_neil_vilaro_wilson-howard_modave_george_odedina_lok_carek_et al._2022, title={Telehealth and racial disparities in colorectal cancer screening: A pilot study of how virtual clinician characteristics influence screening intentions}, volume={6}, ISSN={["2059-8661"]}, DOI={10.1017/cts.2022.386}, abstractNote={Abstract}, number={1}, journal={JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE}, author={Cooks, Eric J. and Duke, Kyle A. and Neil, Jordan M. and Vilaro, Melissa J. and Wilson-Howard, Danyell and Modave, Francois and George, Thomas J. and Odedina, Folakemi T. and Lok, Benjamin C. and Carek, Peter and et al.}, year={2022}, month={Apr} }
 @article{zalake_tavassoli_duke_george_modave_neil_krieger_lok_2021, title={Internet-based tailored virtual human health intervention to promote colorectal cancer screening: design guidelines from two user studies}, volume={15}, ISSN={["1783-8738"]}, DOI={10.1007/s12193-020-00357-5}, abstractNote={Abstract}, number={2}, journal={JOURNAL ON MULTIMODAL USER INTERFACES}, author={Zalake, Mohan and Tavassoli, Fatemeh and Duke, Kyle and George, Thomas and Modave, Francois and Neil, Jordan and Krieger, Janice and Lok, Benjamin}, year={2021}, month={Jun}, pages={147–162} }