Kazunori Hashimoto

Works (6)

Updated: July 6th, 2023 21:16

2019 journal article

Iron-induced transferrin receptor-1 mRNA destabilization: A response to "Neither miR-7-5p nor miR-141-3p is a major mediator of iron-responsive transferrin receptor-1 mRNA degradation"

RNA, 25(11), 1416–1420.

By: M. Miyazawa*, A. Bogdan*, K. Hashimoto* & Y. Tsuji n 

MeSH headings : Iron; MicroRNAs; RNA Stability; RNA, Messenger; Receptors, Transferrin
TL;DR: There are several critical issues contained in the article by Connell and colleagues that require further consideration and the opportunity to reply here. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 28, 2019

2017 journal article

Arsenic-Induced Activation of the Homeodomain-Interacting Protein Kinase 2 (HIPK2) to cAMP-Response Element Binding Protein (CREB) Axis

JOURNAL OF MOLECULAR BIOLOGY, 429(1), 64–78.

By: K. Hashimoto n & Y. Tsuji n 

author keywords: ATF1; HIPK1; CCNA1; CBP; TAF4
MeSH headings : Arsenic / metabolism; Carrier Proteins / metabolism; Cell Line; Cyclic AMP Response Element-Binding Protein / metabolism; Gene Expression Profiling; Humans; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases / metabolism; Serine / metabolism; Transcriptional Activation
TL;DR: The results suggest that the HIPK2-phospho-Ser271 CREB axis is a new arsenic-responsive CREB activation mechanism in parallel with the PKA-ph phosphate-based activation mechanism of Ser133 CREB. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Nuclear lamins and progerin are dispensable for antioxidant Nrf2 response to arsenic and cadmium

CELLULAR SIGNALLING, 33, 69–78.

By: K. Hashimoto n, R. Majumdar n & Y. Tsuji n 

author keywords: HGPS; Nrf2; Lamin; Progerin; Arsenic; Cadmium
MeSH headings : Antioxidants / metabolism; Arsenic / toxicity; Cadmium / toxicity; Cell Line, Tumor; Cell Nucleus / metabolism; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Expression Profiling; Gene Knockdown Techniques; Heme Oxygenase-1 / metabolism; Humans; Kelch-Like ECH-Associated Protein 1 / metabolism; Lamin Type A / metabolism; Lamins / metabolism; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / drug effects; Oxidative Stress / genetics; Phosphorylation / drug effects; Progeria / metabolism; Progeria / pathology; Sequestosome-1 Protein / metabolism
TL;DR: The results suggest that the nuclear lamins and progerin have marginal roles in the activation of the antioxidant Nrf2 response to arsenic and cadmium. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 review

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

[Review of ]. TRENDS IN BIOCHEMICAL SCIENCES, 41(3), 274–286.

By: A. Bogdan n, M. Miyazawa n, K. Hashimoto n & Y. Tsuji n 

MeSH headings : Cell Death; Homeostasis; Humans; Iron / metabolism
TL;DR: New regulators of iron metabolism are highlighted, including iron-trafficking proteins [solute carrier family 39, SLC39, also known as ZRT/IRT-like protein, ZIP; and poly-(rC)-binding protein, PCBP] and a cargo receptor (NCOA4) that is crucial for release of ferritin-bound iron. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 review

Siderophores in Iron Metabolism: From Mechanism to Therapy Potential

[Review of ]. TRENDS IN MOLECULAR MEDICINE, 22(12), 1077–1090.

By: B. Wilson  n, A. Bogdan n, M. Miyazawa n, K. Hashimoto n & Y. Tsuji n 

MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / immunology; Bacteria / metabolism; Bacterial Infections / drug therapy; Bacterial Infections / immunology; Bacterial Infections / metabolism; Drug Discovery; Host-Pathogen Interactions / drug effects; Humans; Iron / immunology; Iron / metabolism; Lipocalin-2 / immunology; Lipocalin-2 / metabolism; Siderophores / immunology; Siderophores / metabolism
TL;DR: This review discusses the recently described molecular mechanisms of siderophore iron trafficking between host and bacteria, highlighting the therapeutic potential of exploiting pathogen sidersophore machinery for the treatment of antibiotic-resistant bacterial infections. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1

ANTIOXIDANTS & REDOX SIGNALING, 25(17), 953–964.

By: K. Hashimoto n, A. Simmons*, R. Kajino-Sakamoto*, Y. Tsuji n  & J. Ninomiya-Tsuji n 

Contributors: K. Hashimoto n, A. Simmons*, R. Kajino-Sakamoto*, Y. Tsuji n  & J. Ninomiya-Tsuji n 

author keywords: intestine; TAK1; Nrf2; Keap1; p62/SQSTM
MeSH headings : Animals; Antioxidants / metabolism; Cell Line; Gene Expression Regulation; Humans; Intestinal Mucosa / metabolism; Kelch-Like ECH-Associated Protein 1 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Models, Biological; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress; Protein Binding; Proteolysis; Reactive Oxygen Species / metabolism; Sequestosome-1 Protein / metabolism
TL;DR: The results identify for the first time that TAK1 is a modulator of p62/SQSTM1-dependent Keap1 degradation and maintains the steady state-level of Nrf2, important for homeostatic antioxidant protection in the intestinal epithelium. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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