Works (6)
Updated: July 6th, 2023 21:16
2019 journal article
Iron-induced transferrin receptor-1 mRNA destabilization: A response to "Neither miR-7-5p nor miR-141-3p is a major mediator of iron-responsive transferrin receptor-1 mRNA degradation"
RNA, 25(11), 1416–1420.
MeSH headings : Iron; MicroRNAs; RNA Stability; RNA, Messenger; Receptors, Transferrin
TL;DR:
There are several critical issues contained in the article by Connell and colleagues that require further consideration and the opportunity to reply here.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 28, 2019
2017 journal article
Nuclear lamins and progerin are dispensable for antioxidant Nrf2 response to arsenic and cadmium
CELLULAR SIGNALLING, 33, 69–78.
author keywords: HGPS; Nrf2; Lamin; Progerin; Arsenic; Cadmium
MeSH headings : Antioxidants / metabolism; Arsenic / toxicity; Cadmium / toxicity; Cell Line, Tumor; Cell Nucleus / metabolism; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Expression Profiling; Gene Knockdown Techniques; Heme Oxygenase-1 / metabolism; Humans; Kelch-Like ECH-Associated Protein 1 / metabolism; Lamin Type A / metabolism; Lamins / metabolism; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / drug effects; Oxidative Stress / genetics; Phosphorylation / drug effects; Progeria / metabolism; Progeria / pathology; Sequestosome-1 Protein / metabolism
TL;DR:
The results suggest that the nuclear lamins and progerin have marginal roles in the activation of the antioxidant Nrf2 response to arsenic and cadmium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Arsenic-Induced Activation of the Homeodomain-Interacting Protein Kinase 2 (HIPK2) to cAMP-Response Element Binding Protein (CREB) Axis
JOURNAL OF MOLECULAR BIOLOGY, 429(1), 64–78.
author keywords: ATF1; HIPK1; CCNA1; CBP; TAF4
MeSH headings : Arsenic / metabolism; Carrier Proteins / metabolism; Cell Line; Cyclic AMP Response Element-Binding Protein / metabolism; Gene Expression Profiling; Humans; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases / metabolism; Serine / metabolism; Transcriptional Activation
TL;DR:
The results suggest that the HIPK2-phospho-Ser271 CREB axis is a new arsenic-responsive CREB activation mechanism in parallel with the PKA-ph phosphate-based activation mechanism of Ser133 CREB.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 review
Siderophores in Iron Metabolism: From Mechanism to Therapy Potential
[Review of ]. TRENDS IN MOLECULAR MEDICINE, 22(12), 1077–1090.
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / immunology; Bacteria / metabolism; Bacterial Infections / drug therapy; Bacterial Infections / immunology; Bacterial Infections / metabolism; Drug Discovery; Host-Pathogen Interactions / drug effects; Humans; Iron / immunology; Iron / metabolism; Lipocalin-2 / immunology; Lipocalin-2 / metabolism; Siderophores / immunology; Siderophores / metabolism
TL;DR:
This review discusses the recently described molecular mechanisms of siderophore iron trafficking between host and bacteria, highlighting the therapeutic potential of exploiting pathogen sidersophore machinery for the treatment of antibiotic-resistant bacterial infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1
ANTIOXIDANTS & REDOX SIGNALING, 25(17), 953–964.
Contributors: n, A. Simmons*, R. Kajino-Sakamoto*, Y. Tsuji n & J. Ninomiya-Tsuji n
author keywords: intestine; TAK1; Nrf2; Keap1; p62/SQSTM
MeSH headings : Animals; Antioxidants / metabolism; Cell Line; Gene Expression Regulation; Humans; Intestinal Mucosa / metabolism; Kelch-Like ECH-Associated Protein 1 / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Mice; Mice, Knockout; Models, Biological; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress; Protein Binding; Proteolysis; Reactive Oxygen Species / metabolism; Sequestosome-1 Protein / metabolism
TL;DR:
The results identify for the first time that TAK1 is a modulator of p62/SQSTM1-dependent Keap1 degradation and maintains the steady state-level of Nrf2, important for homeostatic antioxidant protection in the intestinal epithelium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018
2015 review
Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease
[Review of ]. TRENDS IN BIOCHEMICAL SCIENCES, 41(3), 274–286.
MeSH headings : Cell Death; Homeostasis; Humans; Iron / metabolism
TL;DR:
New regulators of iron metabolism are highlighted, including iron-trafficking proteins [solute carrier family 39, SLC39, also known as ZRT/IRT-like protein, ZIP; and poly-(rC)-binding protein, PCBP] and a cargo receptor (NCOA4) that is crucial for release of ferritin-bound iron.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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