Ke Huang

Wei, S.-Y., Shelton, S. E., Chen, Y.-C., & Huang, K. (2025). In vivo trafficking of cancer-derived exosomes and their role in metastasis. Extracellular Vesicle. https://doi.org/10.1016/j.vesic.2024.100063

Yao, J., Li, J., Zhu, D., Li, Y., Tasoudis, P., Liu, S., … Huang, K. (2024). An infusible biologically active adhesive for chemotherapy-related heart failure in elderly rats. BIOACTIVE MATERIALS, 40, 571–581. https://doi.org/10.1016/j.bioactmat.2024.06.020

Li, J., Sun, S., Zhu, D., Mei, X., Lyu, Y., Huang, K., … Cheng, K. (2024). Inhalable Stem Cell Exosomes Promote Heart Repair After Myocardial Infarction. CIRCULATION, 150(9), 710–723. https://doi.org/10.1161/CIRCULATIONAHA.123.065005

Kwon, H.-jin, Wu, Y., Li, Y., Yuan, G., Lopez, R., Huang, K., & Bai, W. (2024, June 3). On-demand drug delivery bioelectronics through a water-processable low dimensional highly conductive MXene layer. LAB ON A CHIP, Vol. 6. https://doi.org/10.1039/d4lc00234b

Wu, Y., Li, Y., Liu, Y., Zhu, D., Xing, S., Lambert, N., … Bai, W. (2024). Orbit symmetry breaking in MXene implements enhanced soft bioelectronic implants. SCIENCE ADVANCES, 10(40). https://doi.org/10.1126/sciadv.adp8866

Wu, Y., Liu, Y., Li, Y., Wei, Z., Xing, S., Wang, Y., … Bai, W. (2024). Symmetry engineering in 2D bioelectronics facilitating augmented biosensing interfaces. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 121(48). https://doi.org/10.1073/pnas.2412684121

Mei, X., Li, J., Wang, Z., Zhu, D., Huang, K., Hu, S., … Cheng, K. (2023). An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection. Nature Materials, 2. https://doi.org/10.1038/s41563-023-01475-7

Zhu, D., Liu, S., Huang, K., Li, J., Mei, X., Li, Z., & Cheng, K. (2023). Intrapericardial long non-coding RNA–<i>Tcf21</i> antisense RNA inducing demethylation administration promotes cardiac repair. European Heart Journal, 44(19), 1748–1760. https://doi.org/10.1093/eurheartj/ehad114

Chen, J., Tang, X., Wang, Z., Perez, A., Yao, B., Huang, K., … King, M. W. W. (2023, June 26). Techniques for navigating postsurgical adhesions: Insights into mechanisms and future directions. BIOENGINEERING & TRANSLATIONAL MEDICINE, Vol. 6. https://doi.org/10.1002/btm2.10565

Chee, E., Mihalko, E., Nellenbach, K., Sollinger, J., Huang, K., Hon, M., … Brown, A. (2023). Wound‐triggered shape change microgels for the development of enhanced biomimetic function platelet‐like particles. Journal of Biomedical Materials Research Part A, 112(4), 613–624. https://doi.org/10.1002/jbm.a.37625

Chingale, M., Cheng, K., & Huang, K. (2021). 3D Bioprinting Technology – One Step Closer Towards Cardiac Tissue Regeneration. Frontiers in Materials, 8. https://doi.org/10.3389/fmats.2021.804134

Popowski, K. D., Moatti, A., Scull, G., Silkstone, D., Lutz, H., López de Juan Abad, B., … Cheng, K. (2022). Inhalable dry powder mRNA vaccines based on extracellular vesicles. Matter, 5(9), 2960–2974. https://doi.org/10.1016/j.matt.2022.06.012

Zhu, D., Liu, S., Huang, K., Wang, Z., Hu, S., Li, J., … Cheng, K. (2022). Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3. CIRCULATION RESEARCH, 131(10), E135–E150. https://doi.org/10.1161/CIRCRESAHA.122.321384

Cheng, G., Zhu, D., Huang, K., & Caranasos, T. G. (2022). Minimally invasive delivery of a hydrogel-based exosome patch to prevent heart failure. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 169, 113–121. https://doi.org/10.1016/j.yjmcc.2022.04.020

Huang, K., & Cheng, K. (2022). Sealing the heart from the inside out. Nature Biomedical Engineering, 7(2), 87–88. https://doi.org/10.1038/s41551-022-00981-4

Liu, Y., Menon, R., Putcha, A., Huang, K., Bonilla, L., Vora, R., … Bai, W. (2022, June 29). Skin-Interfaced Deep-Tissue Sensing Patch via Microneedle Waveguides. ADVANCED MATERIALS TECHNOLOGIES, Vol. 6. https://doi.org/10.1002/admt.202200468

Liu, Y., Menon, R., Putcha, A., Huang, K., Bonilla, L., Vora, R., … Bai, W. (2022). Skin‐Interfaced Deep‐Tissue Sensing Patch via Microneedle Waveguides (Adv. Mater. Technol. 9/2022). Advanced Materials Technologies, 7(9), 2270058. https://doi.org/10.1002/admt.202270058

Yao, J., Huang, K., Zhu, D., Chen, T., Jiang, Y., Zhang, J., … Cheng, K. (2021). A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction. ACS NANO, 15(7), 11099–11111. https://doi.org/10.1021/acsnano.1c00628

Mei, X., Zhu, D., Li, J., Huang, K., Hu, S., Li, Z., … Cheng, K. (2021). A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs. MED, 2(11), 1253-+. https://doi.org/10.1016/j.medj.2021.10.001

Zhang, S., Zhu, D., Li, Z., Huang, K., Hu, S., Lutz, H., … Cheng, K. (2021). A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency. THERANOSTICS, 11(18), 8894–8908. https://doi.org/10.7150/thno.61690

Li, J., Hu, S., Zhu, D., Huang, K., Mei, X., Abad, B. L. de J., & Cheng, K. (2021). [Review of All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 10(8). https://doi.org/10.1161/JAHA.120.020402

Chingale, M., Zhu, D., Cheng, K., & Huang, K. (2021). Bioengineering Technologies for Cardiac Regenerative Medicine. Frontiers in Bioengineering and Biotechnology, 9. https://doi.org/10.3389/fbioe.2021.681705

Liu, M., Lutz, H., Zhu, D., Huang, K., Li, Z., Dinh, P. U. C., … Cheng, K. (2021). Cardiac Repair: Bispecific Antibody Inhalation Therapy for Redirecting Stem Cells from the Lungs to Repair Heart Injury (Adv. Sci. 1/2021). Advanced Science, 8(1), 2170005. https://doi.org/10.1002/advs.202170005

Hu, S., Li, Z., Shen, D., Zhu, D., Huang, K., Su, T., … Cheng, K. (2021). Exosome-eluting stents for vascular healing after ischaemic injury. NATURE BIOMEDICAL ENGINEERING, 5(10), 1174–1188. https://doi.org/10.1038/s41551-021-00705-0

Wang, X., Hu, S., Li, J., Zhu, D., Wang, Z., Cores, J., … Huang, K. (2021). Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair. ACS APPLIED MATERIALS & INTERFACES, 13(47), 55767–55779. https://doi.org/10.1021/acsami.1c08044

Li, J., Lv, Y., Zhu, D., Mei, X., Huang, K., Wang, X., … Wang, J. (2022). Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction. CHEMICAL ENGINEERING JOURNAL, 427. https://doi.org/10.1016/j.cej.2021.131581

Zhu, D., Li, Z., Huang, K., Caranasos, T. G., Rossi, J. S., & Cheng, K. (2021). Minimally invasive delivery of therapeutic agents by hydrogel injection into the pericardial cavity for cardiac repair. NATURE COMMUNICATIONS, 12(1). https://doi.org/10.1038/s41467-021-21682-7

Hu, S., Li, Z., Shen, D., Zhu, D., Huang, K., Su, T., … Cheng, K. (2021). Publisher Correction: Exosome-eluting stents for vascular healing after ischaemic injury. Nature Biomedical Engineering, 5(10), 1239. https://doi.org/10.1038/s41551-021-00727-8

Hsu, Y., Huang, K., & Cheng, K. (2021). Resuscitating the Field of Cardiac Regeneration: Seeking Answers from Basic Biology. Advanced Biology, 6(2), 2101133. https://doi.org/10.1002/adbi.202101133

Huang, K., Ozpinar, E. W., Su, T., Tang, J., Shen, D., Qiao, L., … Cheng, K. (2020). An off-the-shelf artificial cardiac patch improves cardiac repair after myocardial infarction in rats and pigs. Science Translational Medicine, 12(538). https://doi.org/10.1126/scitranslmed.aat9683

Su, T., Huang, K., Mathews, K. G., Scharf, V. F., Hu, S., Li, Z., … Cheng, K. (2020). Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs. ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(11), 6309–6320. https://doi.org/10.1021/acsbiomaterials.0c00942

Hu, S., Li, Z., Lutz, H., Huang, K., Su, T., Cores, J., … Cheng, K. (2020). Dermal exosomes containing miR-218-5p promote hair regeneration by regulating beta-catenin signaling. SCIENCE ADVANCES, 6(30). https://doi.org/10.1126/sciadv.aba1685

Dinh, P.-U. C., Paudel, D., Brochu, H., Popowski, K. D., Gracieux, M. C., Cores, J., … Cheng, K. (2020). Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis. NATURE COMMUNICATIONS, 11(1). https://doi.org/10.1038/s41467-020-14344-7

Li, Z., Hu, S., Huang, K., Su, T., Cores, J., & Cheng, K. (2020). Targeted anti-IL-1 beta platelet microparticles for cardiac detoxing and repair. SCIENCE ADVANCES, 6(6). https://doi.org/10.1126/sciadv.aay0589

Qiao, L., Hu, S., Huang, K., Su, T., Li, Z., Vandergriff, A., … Cheng, K. (2020). Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs. THERANOSTICS, 10(8), 3474–3487. https://doi.org/10.7150/thno.39434

Shen, D., Li, Z., Hu, S., Huang, K., Su, T., Liang, H., … Cheng, K. (2019). Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells. NANO LETTERS, 19(3), 1883–1891. https://doi.org/10.1021/acs.nanolett.8b04970

Huang, K., Li, Z., Su, T., Shen, D., Hu, S., & Cheng, K. (2019). Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells. ADVANCED THERAPEUTICS, 2(10). https://doi.org/10.1002/adtp.201900009

Liu, F., Hu, S., Yang, H., Li, Z., Huang, K., Su, T., … Cheng, K. (2019). Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome. ADVANCED HEALTHCARE MATERIALS, 8(14). https://doi.org/10.1002/adhm.201900411

Dinh, P.-U., Paudel, D., Brochu, H., Cores, J., Huang, K., Hensley, M. T., … Cheng, K. (2019). Inhalation of Lung Spheroid Cell-Secretome and Exosomes Promotes Therapeutic Lung Repair in Rodent Models of Pulmonary Fibrosis. In A29 Emerging Concepts in Lung Fibrosis (Vol. 199, pp. 1225–1225). https://doi.org/10.1164/ajrccm-conference.2019.199.1_MeetingAbstracts.A1225

Hu, S., Li, Z., Cores, J., Huang, K., Su, T., Dinh, P.-U., & Cheng, K. (2019). Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging. ACS NANO, 13(10), 11273–11282. https://doi.org/10.1021/acsnano.9b04384

Qiao, L., Hu, S., Liu, S., Zhang, H., Ma, H., Huang, K., … Cheng, K. (2019). microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential. JOURNAL OF CLINICAL INVESTIGATION, 129(6), 2237–2250. https://doi.org/10.1172/JCI123135

Huang, K., Hu, S., & Cheng, K. (2018). A New Era of Cardiac Cell Therapy: Opportunities and Challenges. Advanced Healthcare Materials, 8(2), 1801011. https://doi.org/10.1002/adhm.201801011

Su, T., Huang, K., Daniele, M. A., Hensley, M. T., Young, A. T., Tang, J., … Cheng, K. (2018). Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction. ACS APPLIED MATERIALS & INTERFACES, 10(39), 33088–33096. https://doi.org/10.1021/acsami.8b13571

Tang, J., Wang, J., Huang, K., Ye, Y., Su, T., Qiao, L., … Cheng, K. (2018). Cardiac cell-integrated microneedle patch for treating myocardial infarction. SCIENCE ADVANCES, 4(11). https://doi.org/10.1126/sciadv.aat9365

Tang, J.-N., Cores, J., Huang, K., Cui, X.-L., Luo, L., Zhang, J.-Y., … Cheng, K. (2018). Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future. Stem Cells Translational Medicine, 7(4), 354–359. https://doi.org/10.1002/sctm.17-0196

Liang, H., Huang, K., Su, T., Li, Z., Hu, S., Dinh, P.-U., … Cheng, K. (2018). Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure. ACS Nano, 12(7), 6536–6544. https://doi.org/10.1021/acsnano.8b00553

Su, T., Huang, K., Ma, H., Liang, H., Dinh, P.-U., Chen, J., … Cheng, K. (2019). Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury. ADVANCED FUNCTIONAL MATERIALS, 29(4). https://doi.org/10.1002/adfm.201803567

Li, Z., Shen, D., Hu, S., Su, T., Huang, K., Liu, F., … Cheng, K. (2018). Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair. ACS NANO, 12(12), 12193–12200. https://doi.org/10.1021/acsnano.8b05892

Mihalko, E., Huang, K., Sproul, E., Cheng, K., & Brown, A. C. (2018). Targeted Treatment of Ischemic and Fibrotic Complications of Myocardial Infarction Using a Dual-Delivery Microgel Therapeutic. ACS Nano, 12(8), 7826–7837. https://doi.org/10.1021/acsnano.8b01977

Tang, J., Su, T., Huang, K., Dinh, P.-U., Wang, Z., Vandergriff, A., … Cheng, K. (2018). Targeted repair of heart injury by stem cells fused with platelet nanovesicles. Nature Biomedical Engineering, 2(1), 17–26. https://doi.org/10.1038/s41551-017-0182-x

Vandergriff, A., Huang, K., Shen, D., Hu, S., Hensley, M. T., Caranasos, T. G., … Cheng, K. (2018). Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide. THERANOSTICS, 8(7), 1869–1878. https://doi.org/10.7150/thno.20524

Su, T., Daniele, M. A., Erb, P. D., Huang, K., Hensley, M. T., Young, A. T., … Cheng, K. (2017). Hydrodynamically Controlled Fabrication of Three-dimensional Microvasculature for Engineering Thick Vascularized Cardiac Tissues. Tissue Engineering Part A, 23(S1), 134–134.