@article{hobbs_davis_cooper_ueda_burke_sheats_2024, title={Hemadsorption extracorporeal therapy removes cytokines ex vivo in horses}, volume={85}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.24.01.0022}, abstractNote={Plasma cytokine adsorption has shown benefit as an adjunctive therapy in human sepsis but has yet to be investigated in horses. We hypothesized that ex vivo filtration of equine plasma with a novel cytokine adsorption device would significantly reduce concentrations of lipopolysaccharide-stimulated cytokines. We also hypothesized that the device would adsorb medications commonly used to treat sepsis.8 horses owned by North Carolina State University.Four liters of heparinized whole blood was collected from healthy adult horses (n = 8) and stimulated with lipopolysaccharide (100 ng/mL) for 6 hours (37 °C.) from June 4, 2023, to December 15, 2023. Plasma was filtered through a cytokine adsorption device or sham circuit. Samples were collected at 11 time points for multiplex cytokine analysis. Chemistry analysis was performed before and after filtration. To investigate the impact of the device on medication concentrations, equine plasma containing potassium penicillin, gentamicin, and flunixin meglumine was filtered through the cytokine adsorption device or sham for 6 hours. Drug concentrations before and after filtration were determined by ultra-high-performance liquid chromatography. Prefiltration versus postfiltration sample concentrations were analyzed by Student paired t test using GraphPad Prism 9.0 (P < .05).Filtration of lipopolysaccharide-stimulated equine plasma (n = 8) for 6 hours resulted in significant mean reductions in the cytokines IL-10, IL-5, IL-8, tumor necrosis factor-α (TNF-α), and IL-1β, as well as albumin. Drug concentrations of potassium penicillin, gentamicin, and flunixin meglumine were also significantly reduced by filtration.This work provides proof of concept for further investigation of extracorporeal cytokine adsorption as a potential adjunct treatment for equine sepsis.}, number={6}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Hobbs, Kallie J. and Davis, Jennifer L. and Cooper, Bethanie L. and Ueda, Yu and Burke, Megan J. and Sheats, Katie}, year={2024}, month={Jun} }
 @article{elane_bauck_hobbs_king_fields_ziegler_blikslager_2024, title={Review of venipuncture and intravenous catheterization techniques in pigs}, url={http://dx.doi.org/10.2460/javma.24.03.0169}, DOI={10.2460/javma.24.03.0169}, abstractNote={Abstract The number of companion pigs in the US is increasing, as is the frequency with which they present to primary companion care practices. However, pigs are often an understudied species in veterinary curricula, and many students graduate from veterinary school with minimal porcine handling experience. Coupled with the poor peripheral vascular access associated with pigs, this presents a challenge for many new graduates and other primary care veterinarians seeking to improve their knowledge of porcine handling, anatomy, and medical care. Furthermore, much of the available veterinary literature regarding porcine venous access is dated, limited to technical notes, or inaccessible to many primary care veterinarians. This review aims to supplement this lack of knowledge by discussing techniques in restraint, sedation, venipuncture, and catheterization of companion pigs as a reference for veterinarians and researchers alike.}, journal={Journal of the American Veterinary Medical Association}, author={Elane, George and Bauck, Anje G. and Hobbs, Kallie J. and King, Ailbhe and Fields, Claire and Ziegler, Amanda and Blikslager, Anthony}, year={2024}, month={Jun} }
 @article{ludwig_hobbs_mckinney-aguirre_gonzalez_2023, title={Biomarkers of Intestinal Injury in Colic}, volume={13}, ISSN={2076-2615}, url={http://dx.doi.org/10.3390/ani13020227}, DOI={10.3390/ani13020227}, abstractNote={Biomarkers are typically proteins, enzymes, or other molecular changes that are elevated or decreased in body fluids during the course of inflammation or disease. Biomarkers pose an extremely attractive tool for establishing diagnoses and prognoses of equine gastrointestinal colic, one of the most prevalent causes of morbidity and mortality in horses. This topic has received increasing attention because early diagnosis of some forms of severe colic, such as intestinal ischemia, would create opportunities for rapid interventions that would likely improve case outcomes. This review explores biomarkers currently used in equine medicine for colic, including acute phase proteins, proinflammatory cytokines, markers of endotoxemia, and tissue injury metabolites. To date, no single biomarker has been identified that is perfectly sensitive and specific for intestinal ischemia; however, L-lactate has been proven to be a very functional and highly utilized diagnostic tool. However, further exploration of other biomarkers discussed in this review may provide the key to accelerated identification, intervention, and better outcomes for horses suffering from severe colic.}, number={2}, journal={Animals}, publisher={MDPI AG}, author={Ludwig, Elsa K. and Hobbs, Kallie J. and McKinney-Aguirre, Caroline A. and Gonzalez, Liara M.}, year={2023}, month={Jan}, pages={227} }
 @article{hobbs_young_nannarone_luethy_hopster-iversen_mckenzie_ludwig_2023, title={Intravenous loss of over-the-wire catheter guidewires in 13 horses}, volume={12}, ISSN={["1939-1676"]}, url={https://doi.org/10.1111/jvim.16960}, DOI={10.1111/jvim.16960}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Hobbs, Kallie J. and Young, Kimberly A. S. and Nannarone, Sara and Luethy, Daniela and Hopster-Iversen, Charlotte and Mckenzie, Harold C. and Ludwig, Elsa K.}, year={2023}, month={Dec} }
 @article{hobbs_johnson_wiedmeyer_schultz_foote_2023, title={Plasma syndecan‐1 concentration as a biomarker for endothelial glycocalyx degradation in septic adult horses}, url={https://doi.org/10.1111/evj.13862}, DOI={10.1111/evj.13862}, abstractNote={Abstract}, journal={Equine Veterinary Journal}, author={Hobbs, Kallie J. and Johnson, Philip J. and Wiedmeyer, Charles E. and Schultz, Loren and Foote, Christopher A.}, year={2023}, month={May} }
 @article{elane_portela_hobbs_bauck_biedrzycki_2023, title={Sedated cesarean sections are associated with increased kid survival compared to general anesthesia in goats: retrospective cohort of 45 cases (2011–2021)}, volume={1}, url={http://dx.doi.org/10.2460/javma.22.10.0466}, DOI={10.2460/javma.22.10.0466}, abstractNote={Abstract}, journal={Journal of the American Veterinary Medical Association}, publisher={American Veterinary Medical Association (AVMA)}, author={Elane, George L. and Portela, Diego A. and Hobbs, Kallie J. and Bauck, Anje G. and Biedrzycki, Adam H.}, year={2023}, month={Jan}, pages={1–6} }
 @article{hobbs_luethy_davis_mallicote_torcivia_kulp_stefanovski_futterman_cooper_eps_2023, title={The effects of orally administered trazodone on ambulation and recumbency in healthy horses}, url={https://doi.org/10.1111/jvim.16821}, DOI={10.1111/jvim.16821}, abstractNote={Abstract}, journal={Journal of Veterinary Internal Medicine}, author={Hobbs, Kallie and Luethy, Daniela and Davis, Jennifer and Mallicote, Martha and Torcivia, Catherine and Kulp, Jeaneen and Stefanovski, Darko and Futterman, Catherine and Cooper, Freya and Eps, Andrew}, year={2023}, month={Sep} }
 @article{nakamae_hobbs_ziegler_rivero_kennedy_stockler_gomez_2022, title={Gastrointestinal foreign bodies in pet pigs: 17 cases}, volume={36}, url={http://dx.doi.org/10.1111/jvim.16429}, DOI={10.1111/jvim.16429}, abstractNote={Abstract}, number={3}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Nakamae, Yoko and Hobbs, Kallie J. and Ziegler, Jessie and Rivero, Luis A. and Kennedy, Shari and Stockler, Jenna and Gomez, Diego E.}, year={2022}, month={May}, pages={1185–1189} }
 @article{hobbs_porter_wait_dark_mackay_2022, title={Magnetic resonance imaging of the normal equine pituitary gland}, url={https://doi.org/10.1111/vru.13072}, DOI={10.1111/vru.13072}, abstractNote={Abstract}, journal={Veterinary Radiology & Ultrasound}, author={Hobbs, Kallie J. and Porter, Erin and Wait, Courtney and Dark, Michael and MacKay, Robert J.}, year={2022}, month={Jul} }
 @article{hobbs_wait_porter_luethy_2022, title={What Is Your Diagnosis?}, volume={6}, url={http://dx.doi.org/10.2460/javma.22.03.0117}, DOI={10.2460/javma.22.03.0117}, abstractNote={A 60-year-old uncircumcised male presented with asymptomatic growth on the glans penis of 7 years duration. There were no complaints or past history suggestive of sexually transmitted diseases (STDs). There was no history of trauma to penis, localized dermatoses, systemic diseases or any prolonged medications. There was no history of any significant illness in the partner. The condition was initially diagnosed clinically as a case of penile psoriasis and treated with potent topical corticosteroids. There was partial response to the treatment with some reduction in scaling, but the patch gradually increased in size and became elevated over the course of time. Over the past 1 year, the lesion started increasing in the size, developed verrucosity and thick mica-like scaling. On examination, there was hyperkeratotic, hypertrophic, verrucous plaque with thick scaling on the glans and rim of erythema. His S. VDRL and S. HIV tests were normal. Hematological, biochemical and radiological examination did not reveal any abnormality. Histopathological examination with hematoxylin and eosin staining showed irregular exo-endophytic hyperplasia of the epidermis with elongated downgrowths. There was prominent mitotic activity of the basal and suprabasal layers of the epidermis with mild atypia and pleomorphism of nuclei. The surface showed a marked thick, parakeratotic stratum corneum. A focally lichenoid lymphoplasmacytic}, journal={Journal of the American Veterinary Medical Association}, publisher={American Veterinary Medical Association (AVMA)}, author={Hobbs, Kallie J. and Wait, Courtney and Porter, Erin and Luethy, Daniela}, year={2022}, month={Jun}, pages={1–3} }
 @article{obstipation in pet pigs: 24 cases._2021, url={https://europepmc.org/articles/PMC8281943}, journal={The Canadian veterinary journal = La revue veterinaire canadienne}, year={2021}, month={Aug} }
 @article{presumptive fibrocartilaginous embolic myelopathy in a pot-bellied pig._2021, url={https://europepmc.org/articles/PMC7808203}, journal={The Canadian veterinary journal = La revue veterinaire canadienne}, year={2021}, month={Feb} }
 @article{hobbs_johnson_scharf_cross_wallace_2021, title={Use of a jugular vein model for the instruction of equine intravenous catheter placement by third‐and fourth‐year veterinary students}, url={https://doi.org/10.1111/eve.13260}, DOI={10.1111/eve.13260}, abstractNote={Summary}, journal={Equine Veterinary Education}, author={Hobbs, K. J. and Johnson, P. J. and Scharf, M. E. and Cross, D. T. and Wallace, L. L.}, year={2021}, month={May} }