Works (12)
Updated: August 18th, 2023 21:20
2007 journal article
Fine oil combustion particle bioavailable constituents induce molecular profiles of oxidative stress, altered function, and cellular injury in cardiomyocytes
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 70(21), 1824–1837.
MeSH headings : Animals; Carbon / toxicity; Cell Survival; Cells, Cultured; Coal Ash; Molecular Biology; Myocytes, Cardiac / drug effects; Oligonucleotide Array Sequence Analysis; Oxidative Stress / drug effects; Particulate Matter / toxicity; Rats; Rats, Sprague-Dawley
TL;DR:
Genomic alterations in pathways related to IGF-1, VEGF, IL-2, PI3/AKT, cardiovascular disease, and free radical scavenging were detected 1 h postexposure to ROFA-L.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
In situ pulmonary localization of air pollution particle-induced oxidative stress
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 70(22), 1929–1935.
MeSH headings : Air Pollutants / toxicity; Air Pollution / adverse effects; Animals; Carbon / toxicity; Coal Ash; Heme Oxygenase-1 / genetics; Heme Oxygenase-1 / metabolism; Luciferases / genetics; Luciferases / metabolism; Luminescence; Lung / drug effects; Lung / metabolism; Male; Membrane Proteins / genetics; Membrane Proteins / metabolism; Mice; Mice, Transgenic; Models, Animal; Oxidative Stress; Particulate Matter / toxicity; Power Plants
TL;DR:
The results suggest that the variability observed in the methods of detection for Luciferase may be due to a localization of cells expressing luciferase within tissue samples, demonstrating that the HO-1-luc transgenic mouse model is the preferred method to detect and pinpoint in vivo particle-induced, oxidative lung injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Residual oil fly ash induces cytotoxicity and mucin secretion by guinea pig tracheal epithelial cells via an oxidant-mediated mechanism
TOXICOLOGY AND APPLIED PHARMACOLOGY, 163(3), 221–230.
author keywords: mucin; cytotoxicity; residual oil fly ash; oxidant
MeSH headings : Animals; Antioxidants / pharmacology; Carbon / toxicity; Cell Survival / drug effects; Cells, Cultured; Coal Ash; Dust / adverse effects; Epithelial Cells / drug effects; Gene Expression / drug effects; Guinea Pigs; Industrial Waste; Metals / toxicity; Mucins / biosynthesis; Mucins / genetics; Mucins / metabolism; Oxidants / pharmacology; Particulate Matter; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Trachea / cytology; Trachea / drug effects; Trachea / metabolism
TL;DR:
ROFA enhances mucin secretion and generates toxicity in vitro to airway epithelium via a mechanism(s) involving generation of oxidant stress, perhaps related to depletion of cellular antioxidant capacity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 article
Residual oil fly ash (ROFA) increases mucin secretion and mucin gene expression in guinea pig airway epithelial cells in vitro.
American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A888.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Role of soluble metals in oil fly ash-induced airway epithelial injury and cytokine gene expression
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 277(3), L498–L510.
author keywords: particulate matter; airway epithelial cells; gene induction; oxidative stress
MeSH headings : Animals; Carbon / pharmacology; Cell Survival / drug effects; Cells, Cultured; Chemokine CXCL2; Coal Ash; Cytokines / genetics; Epithelial Cells / drug effects; Epithelial Cells / physiology; Gene Expression / drug effects; Interleukin-6 / genetics; Male; Metals / pharmacology; Monokines / genetics; Nitric Oxide Synthase / genetics; Nitric Oxide Synthase Type II; Particulate Matter; Rats; Rats, Sprague-Dawley; Solubility; Trachea / drug effects; Trachea / pathology; Trachea / physiopathology
TL;DR:
Generation of an oxidative stress was critical to induction of the ROFA- or vanadium-induced effects on airway epithelial gene expression, cytokine production, and cytotoxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 article
Exposure of differentiated rodent airway epithelial cells in vitro to particles of residual fly ash (ROFA) induces cytotoxicity and generation of reactive oxygen species.
Proceedings of the 10th International Colloquium on Lung Fibrosis, Vol. 10, p. 26.
Source: NC State University Libraries
Added: August 6, 2018
1998 article
Particles of Residual Oil Fly Ash (ROFA) induce toxicity and mucin hypersecretion in rodent airway epithelial cells in vitro via an oxidant-mediated mechanism.
Toxicology Letters, Vol. 95, p. 224.
Source: NC State University Libraries
Added: August 6, 2018
1998 article
Residual oil fly ash (ROFA) induces cytotoxicity and enhances mucin secretion by guinea pig airway epithelial cells in vitro via an oxidant mediated mechanism.
American Journal of Respiratory and Critical Care Medicine, Vol. 157, p. A150.
Source: NC State University Libraries
Added: August 6, 2018
1998 article
Vanadium content and related oxidative stress appear to determine airway epithelial cell responses to emission source particulate matter.
FASEB Journal, Vol. 12, p. A337.
Source: NC State University Libraries
Added: August 6, 2018
1997 article
Airway epithelial cell responses to fly ash (ROFA) particles: contribution of soluble transition metals.
American Journal of Respiratory and Critical Care Medicine, Vol. 155, p. A197.
Source: NC State University Libraries
Added: August 6, 2018
1996 article
Injury of rat tracheal epithelial cultures by exposure to residual oil fly ash (ROFA) involves generation of the hydroxyl radical.
American Journal of Respiratory and Critical Care Medicine, Vol. 153, p. A542.
Source: NC State University Libraries
Added: August 6, 2018
1996 article
Role or reactive oxygen and nitrogen species in the response of airway epithelium to particulates.
Proceedings of the 6th International Meeting of the Toxicology of Natural and Man-Made Fibrous and Non-Fibrous Particles., Vol. 6, p. 139.
Source: NC State University Libraries
Added: August 6, 2018
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