Works (5)

Updated: July 17th, 2023 21:18

2022 journal article

Allogeneic and xenogeneic lymphoid reconstitution in a RAG2(-/-)IL2RG(y/-) severe combined immunodeficient pig: A preclinical model for intrauterine hematopoietic transplantation


By: R. Sper n, J. Proctor n, O. Lascina n, L. Guo n, K. Polkoff n, T. Kaeser n, S. Simpson n, L. Borst n ...

author keywords: severe combined immunodeficiency; pig; xenotransplantation; allotransplantation; hematopoietic; RAG2; IL2RG; transgenic
TL;DR: The data shows that the pig thymus provides a microenvironment conducive to engraftment, survival and development of human T-cells and provides evidence that the developing T-cell compartment can be populated to a significant extent by human cells in large animals. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: November 14, 2022

2022 journal article

LGR5 is a conserved marker of hair follicle stem cells in multiple species and is present early and throughout follicle morphogenesis


By: K. Polkoff n, N. Gupta n, A. Green n, Y. Murphy n, J. Chung n, K. Gleason n, S. Simpson*, D. Walker n, B. Collins n, J. Piedrahita n

MeSH headings : Animals; Animals, Genetically Modified; Biomarkers / metabolism; Hair Follicle / metabolism; Humans; Morphogenesis; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Skin; Stem Cells / metabolism; Swine
TL;DR: It is demonstrated that LGR5 is a marker of hair follicle stem cells across species in homeostasis and development and the strong similarities and important differences in expression patterns, gene expression profiles, and developmental processes between species are reported. (via Semantic Scholar)
Source: Web Of Science
Added: June 20, 2022

2022 article

The use of autologous skeletal muscle progenitor cells for adjunctive treatment of presumptive urethral sphincter mechanism incompetence in female dogs

Vaden, S. L., Mathews, K. G., Yoo, J., Williams, J. K., Harris, T., Secoura, P., … Piedrahita, J. (2022, August 5). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 8.

By: S. Vaden n, K. Mathews n, J. Yoo*, J. Williams*, T. Harris n, P. Secoura n, J. Robertson n, K. Gleason n, H. Reynolds n, J. Piedrahita n

Contributors: J. Robertson n

author keywords: canine; regenerative medicine; stem cell; urinary incontinence
MeSH headings : Animals; Dog Diseases / surgery; Dogs; Female; Muscle, Skeletal; Stem Cells; Urethra / surgery; Urinary Incontinence / therapy; Urinary Incontinence / veterinary
TL;DR: Urethral submucosal injection of autologous skeletal muscle progenitor cells (skMPC) can be used adjunctively to improve continence in dogs with difficult to manage USMI. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 26, 2022

2020 journal article

In Vitro Validation of Transgene Expression in Gene-Edited Pias Using CRISPR Transcriptional Activators

CRISPR JOURNAL, 3(5), 409–418.

By: K. Polkoff n, J. Chung n, S. Simpson*, K. Gleason n & J. Piedrahita n

MeSH headings : Animals; Animals, Genetically Modified / genetics; CRISPR-Associated Protein 9 / genetics; CRISPR-Associated Protein 9 / metabolism; Cells, Cultured; Clustered Regularly Interspaced Short Palindromic Repeats; Gene Editing / methods; Gene Expression; Nuclear Transfer Techniques; RNA, Guide, Kinetoplastida / genetics; RNA, Guide, Kinetoplastida / metabolism; Swine; Trans-Activators / genetics; Trans-Activators / metabolism; Transgenes
TL;DR: It is shown that CRISPR-dCas9 transcriptional activators can be used to validate functional transgene insertion in nonexpressing easily cultured cells such as fibroblasts and is a tool that could be used across disciplines and animal species to save time and resources by verifying expected outcomes of gene edits before generating live animals. (via Semantic Scholar)
Source: Web Of Science
Added: November 24, 2020

2018 journal article

High mobility group A2 (HMGA2) deficiency in pigs leads to dwarfism, abnormal fetal resource allocation, and cryptorchidism

Proceedings of the National Academy of Sciences, 115(21), 5420–5425.

By: J. Chung n, X. Zhang n, B. Collins n, R. Sper n, K. Gleason n, S. Simpson n, S. Koh n, J. Sommer n ...

author keywords: HMGA2; dwarfism; swine; gene editing; organ size
MeSH headings : Animals; Cryptorchidism / etiology; Cryptorchidism / pathology; Dwarfism / etiology; Dwarfism / pathology; Female; Fetal Diseases / etiology; Fetal Diseases / pathology; Genotype; HMGA2 Protein / deficiency; HMGA2 Protein / genetics; Litter Size; Male; Nuclear Transfer Techniques / veterinary; Pregnancy; Reproduction; Swine; Swine Diseases / etiology; Swine Diseases / pathology
TL;DR: The results show that the effect of HMGA2 with respect to growth regulation is highly conserved among mammals and opens up the possibility of regulating body and organ size in a variety of mammalian species including food and companion animals. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

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