Works (4)

Updated: July 5th, 2023 15:37

2023 journal article

Acute radiotherapy-associated oral pain may promote tumor growth at distant sites

FRONTIERS IN ONCOLOGY, 13.

By: C. Meneses n, E. Gidcumb n, K. Marcus n, Y. Gonzalez n, Y. Lai n, S. Mishra n, B. Lascelles n, M. Nolan n

author keywords: pain; radiotherapy; sensory nerves; cancer; mouse; TRPV1
TL;DR: This research points towards radiation-induced activation of capsaicin-responsive (TRPV1) neurons as the cause for accelerated growth of tumors at distant (unirradiated) sites. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: June 12, 2023

2022 journal article

Stereotactic radiotherapy (10 Gy X 3) for canine nonlymphomatous intranasal tumors is associated with prolonged survival and minimal risk of severe radiotoxicity

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 260(12), 1496–1506.

By: M. Nolan n, A. Berman n, M. Watson-Skaggs n, C. Quinn n, K. Marcus n, K. Russell n, H. Yoshikawa n, N. Olby n, T. Gieger n

MeSH headings : Dogs; Animals; Retrospective Studies; Dog Diseases / surgery; Quality of Life; Radiosurgery / methods; Radiosurgery / veterinary; Chondrosarcoma / veterinary; Bone Neoplasms / veterinary; Death; Treatment Outcome
TL;DR: Oncologic outcomes following administration of a uniform stereotactic radiotherapy protocol for canine intranasal tumors are described and any clinical or dosimetric factors were predictive of event-free or overall survival time (EFST or OST) are identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: February 13, 2023

2021 journal article

Early radiation-induced oral pain signaling responses are reduced with pentoxifylline treatment

VETERINARY RADIOLOGY & ULTRASOUND, 62(2), 255–263.

By: M. Price n, Y. Lai n, K. Marcus n, J. Robertson n, B. Lascelles n & M. Nolan n

author keywords: glossitis; mucositis; TNF‐ α TRPV1; TRPV4
MeSH headings : Animals; Capsaicin / pharmacology; Histamine / pharmacology; Mice; Pain / prevention & control; Pain / veterinary; Pentoxifylline / therapeutic use; Pilot Projects; Prospective Studies; Radiation-Protective Agents / therapeutic use; Radiotherapy / adverse effects; Sensory System Agents / pharmacology; Signal Transduction / drug effects; Stomatitis / complications; Stomatitis / drug therapy; Stomatitis / etiology; Tumor Necrosis Factor-alpha / analysis; Tumor Necrosis Factor-alpha / metabolism
TL;DR: Although PTX treatment did not reduce glossitis severity or mitigate weight loss in mice with RIM/RAP, it did inhibit the upregulation of TNF-α's receptor that normally accompanies RIM, and it also reduced neuronal responsiveness to each of the aforementioned chemical stimuli. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: January 11, 2021

2017 journal article

Nocifensive Behaviors in Mice with Radiation-Induced Oral Mucositis

RADIATION RESEARCH, 187(3), 397–403.

By: M. Nolan*, C. Long, K. Marcus*, S. Sarmadi, D. Roback*, T. Fukuyama*, W. Baeumer*, B. Lascelles

MeSH headings : Animals; Behavior, Animal / radiation effects; Mice; Neurons / pathology; Neurons / radiation effects; Nociception / radiation effects; Radiation Injuries, Experimental / pathology; Radiation Injuries, Experimental / physiopathology; Stomatitis / pathology; Stomatitis / physiopathology; Trigeminal Ganglion / pathology
TL;DR: Data validate an appropriate model for cancer treatment related discomfort in humans and quantify resultant discomfort, and characterize peripheral sensitization following radiation-induced glossitis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

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