Karen Lynette Marcus

Works (4)

Updated: July 5th, 2023 15:37

2023 article

Acute radiotherapy-associated oral pain may promote tumor growth at distant sites

Meneses, C. S., Gidcumb, E. M., Marcus, K. L., Gonzalez, Y., Lai, Y. H., Mishra, S. K., … Nolan, M. W. (2023, May 19). Frontiers in Oncology, Vol. 13.

By: C. Meneses n, E. Gidcumb  n, K. Marcus n, Y. Gonzalez n, Y. Lai n , S. Mishra n, B. Lascelles n , M. Nolan n 

author keywords: pain; radiotherapy; sensory nerves; cancer; mouse; TRPV1
topics (OpenAlex): Oral health in cancer treatment; Cancer, Stress, Anesthesia, and Immune Response; Effects of Radiation Exposure
TL;DR: This research points towards radiation-induced activation of capsaicin-responsive (TRPV1) neurons as the cause for accelerated growth of tumors at distant (unirradiated) sites. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 12, 2023

2022 article

Stereotactic radiotherapy (10 Gy X 3) for canine nonlymphomatous intranasal tumors is associated with prolonged survival and minimal risk of severe radiotoxicity

Nolan, M. W., Berman, A. R., Watson-Skaggs, M. L., Quinn, C. N., Marcus, K. L., Russell, K., … Gieger, T. L. (2022, June 22). Journal of the American Veterinary Medical Association, Vol. 260, pp. 1496–1506.

By: M. Nolan n , A. Berman  n, M. Watson-Skaggs n, C. Quinn n, K. Marcus n, K. Russell n, H. Yoshikawa n, N. Olby n , T. Gieger n 

MeSH headings : Dogs; Animals; Retrospective Studies; Dog Diseases / surgery; Quality of Life; Radiosurgery / methods; Radiosurgery / veterinary; Chondrosarcoma / veterinary; Bone Neoplasms / veterinary; Death; Treatment Outcome
topics (OpenAlex): Veterinary Oncology Research; Salivary Gland Tumors Diagnosis and Treatment; Oral and Maxillofacial Pathology
TL;DR: Oncologic outcomes following administration of a uniform stereotactic radiotherapy protocol for canine intranasal tumors are described and any clinical or dosimetric factors were predictive of event-free or overall survival time (EFST or OST) are identified. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 13, 2023

2020 journal article

Early radiation‐induced oral pain signaling responses are reduced with pentoxifylline treatment

Veterinary Radiology & Ultrasound, 62(2), 255–263.

By: M. Price n, Y. Lai n , K. Marcus n, J. Robertson n , B. Lascelles n  & M. Nolan n 

author keywords: glossitis; mucositis; TNF‐ α TRPV1; TRPV4
MeSH headings : Animals; Capsaicin / pharmacology; Histamine / pharmacology; Mice; Pain / prevention & control; Pain / veterinary; Pentoxifylline / therapeutic use; Pilot Projects; Prospective Studies; Radiation-Protective Agents / therapeutic use; Radiotherapy / adverse effects; Sensory System Agents / pharmacology; Signal Transduction / drug effects; Stomatitis / complications; Stomatitis / drug therapy; Stomatitis / etiology; Tumor Necrosis Factor-alpha / analysis; Tumor Necrosis Factor-alpha / metabolism
topics (OpenAlex): Oral health in cancer treatment; Effects of Radiation Exposure; Head and Neck Cancer Studies
TL;DR: Although PTX treatment did not reduce glossitis severity or mitigate weight loss in mice with RIM/RAP, it did inhibit the upregulation of TNF-α's receptor that normally accompanies RIM, and it also reduced neuronal responsiveness to each of the aforementioned chemical stimuli. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: January 11, 2021

2017 article

Nocifensive Behaviors in Mice with Radiation-Induced Oral Mucositis

Nolan, M. W., Long, C. T., Marcus, K. L., Sarmadi, S., Roback, D. M., Fukuyama, T., … Lascelles, B. D. X. (2017, February 10). Radiation Research, Vol. 187, pp. 397–403.

By: M. Nolan* , C. Long, K. Marcus*, S. Sarmadi, D. Roback*, T. Fukuyama *, W. Baeumer*, B. Lascelles* 

MeSH headings : Animals; Behavior, Animal / radiation effects; Mice; Neurons / pathology; Neurons / radiation effects; Nociception / radiation effects; Radiation Injuries, Experimental / pathology; Radiation Injuries, Experimental / physiopathology; Stomatitis / pathology; Stomatitis / physiopathology; Trigeminal Ganglion / pathology
topics (OpenAlex): Oral health in cancer treatment; Effects of Radiation Exposure; Cancer, Stress, Anesthesia, and Immune Response
TL;DR: Data validate an appropriate model for cancer treatment related discomfort in humans and quantify resultant discomfort, and characterize peripheral sensitization following radiation-induced glossitis. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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