@article{sharkey_twiddy_peterson_aroche_menegatti_daniele_2023, title={Towards electrochemical control of pH for regeneration of biosensors}, DOI={10.1109/BioSensors58001.2023.10281061}, abstractNote={Most affinity-based biosensors are designed to be single-use devices, based on the measurement of irreversible binding events, which makes longitudinal monitoring resource-intensive, and typically prohibits the measurement of analyte fluctuations over time using the same device. Selective reversal of biorecognition events, i.e., regeneration, may enable repeated and longitudinal use of affinity-based biosensors; however, typical regeneration methods utilize additional chemical reagents, requiring longer processing times and increasing the likelihood of operator error. The development of a “solid-state” regeneration method provides significant value for extending the utility of affinity-based biosensors, such as electrochemical immunosensors and aptasensors. Herein, we report the characterization of a method for electronically controlling pH without additional reagents. Palladium was used to induce pH swings in aqueous electrolytes and buffers by application of an electric potential. The developed system was able to affect acidic and basic pH changes of ± 4. The efficacy of this method was further demonstrated by reversing common affinity-binding complexes and compared to conventional glycine-based regeneration.}, journal={2023 IEEE BIOSENSORS CONFERENCE, BIOSENSORS}, author={Sharkey, Christopher and Twiddy, Jack and Peterson, Kaila L. and Aroche, Angelica F. and Menegatti, Stefano and Daniele, Michael A.}, year={2023} }
 @article{twiddy_peterson_maddocks_macpherson_pimentel_yates_armitano-lago_kiefer_pietrosimone_franz_et al._2022, title={A Low-Cost, Open Source Wireless Body Area Network for Clinical Gait Rehabilitation}, ISSN={["1930-0395"]}, DOI={10.1109/SENSORS52175.2022.9967362}, abstractNote={Wearable inertial sensors represent an opportunity to enable gait monitoring and feedback-based rehabilitation in real-world environments. Here, we describe the development of an inexpensive I MU-based wireless body area network capable of recording 9-axis motion data from 8 sites on the body simultaneously. This system can generate data comparable to existing commercial sensor networks and can distinguish varying loading conditions observed during real-time biofeedback-based human subject testing.}, journal={2022 IEEE SENSORS}, author={Twiddy, Jack and Peterson, Kaila and Maddocks, Grace and MacPherson, Ryan and Pimentel, Ricky and Yates, Max and Armitano-Lago, Cortney and Kiefer, Adam and Pietrosimone, Brian and Franz, Jason and et al.}, year={2022} }
 @article{songkakul_peterson_daniele_bozkurt_2021, title={Preliminary Evaluation of a Solar-Powered Wristband for Continuous Multi-Modal Electrochemical Monitoring}, ISSN={["1558-4615"]}, DOI={10.1109/EMBC46164.2021.9630105}, abstractNote={Continuous, non-invasive wearable measurement of metabolic biomarkers could provide vital insight into patient condition for personalized health and wellness monitoring. We present our efforts towards developing a wearable solar-powered electrochemical platform for multimodal sweat based metabolic monitoring. This wrist-worn wearable system consists of a flexible photovoltaic cell connected to a circuit board containing ultra low power circuitry for sensor data collection, energy harvesting, and wireless data transmission, all integrated into an elastic fabric wristband. The system continuously samples amperometric, potentiometric, temperature, and motion data and wirelessly transmits these to a data aggregator. The full wearable system is 7.5 cm long and 5 cm in diameter, weighs 22 grams, and can run directly from harvested light energy. Relatively low levels of light such as residential lighting (∼200 lux) are sufficient for continuous operation of the system. Excess harvested energy is stored in a small 37 mWh lithium polymer battery. The battery can be charged in ∼14 minutes under full sunlight and can power the system for ∼8 days when fully charged. The system has an average power consumption of 176 µW. The solar-harvesting performance of the system was characterized in a variety of lighting conditions, and the amperometric and potentiometric electrochemical capabilities of the system were validated in vitro.Clinical relevance—The presented solar-powered wearable system enables continuous wireless multi-modal electrochemical monitoring for uninterrupted sensing of metabolic biomarkers in sweat while harvesting energy from indoor lighting or sunlight.}, journal={2021 43RD ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE & BIOLOGY SOCIETY (EMBC)}, author={Songkakul, Tanner and Peterson, Kaila and Daniele, Michael and Bozkurt, Alper}, year={2021}, pages={7316–7319} }
 @article{richardson_maddocks_peterson_daniele_pavlidis_2021, title={Toward Subcutaneous Electrochemical Aptasensors for Neuropeptide Y}, ISSN={["1930-0395"]}, DOI={10.1109/SENSORS47087.2021.9639832}, abstractNote={Subcutaneous sensors, similar to the continuous glucose monitor, are advantageous for identifying healthy and pathological patterns of circulating biomarkers. A biosensor for the detection of neuropeptide Y (NPY), a marker of stress, has been designed and tested for operation in a flexible microneedle form factor. The biosensing principle used is affinity binding of NPY to a DNA aptamer-functionalized electrode. A gold microelectrode was functionalized by formation of a self- assembled monolayer (SAM) of a thiol-modified NPY-binding aptamer and poly(ethylene glycol) methyl ether thiol (PEG). The sensors were evaluated by cyclic voltammetry and electrochemical impedance spectroscopy, resulting in a response to NPY over 400 pM to 200 nM when tested in KCl and K3[Fe(CN)6]/K4[Fe(CN)6], and PBS.}, journal={2021 IEEE SENSORS}, author={Richardson, Hayley and Maddocks, Grace and Peterson, Kaila and Daniele, Michael and Pavlidis, Spyridon}, year={2021} }