Development of an ultrasound-guided transgluteal injection of the pudendal nerve in cats: a cadaveric study
}, volume={49}, ISSN={["1467-2995"]}, url={https://doi.org/10.1016/j.vaa.2021.11.004}, DOI={10.1016/j.vaa.2021.11.004}, abstractNote={To develop an ultrasound-guided interfascial plane technique for injection of the pudendal nerve near its sacral origin in cats.Prospective, randomized, anatomical study.A group of 12 feline cadavers.Gross and ultrasound anatomy of the ischiorectal fossa, the pudendal nerve relationship with parasacral structures, and the interfascial plane were described. Computed tomography was employed to describe a cranial transgluteal approach to the pudendal nerve. Bilateral ultrasound-guided injections were performed in eight cadavers using low [(LV) 0.1 mL kg-1] or high volume [(HV) 0.2 mL kg-1] of ropivacaine-dye solution. Dissections were performed to determine successful staining of the pudendal nerve (>1 cm) and inadvertent staining of the sciatic nerve, and any rectal, urethral, or intravascular puncture. Pudendal nerve staining in groups LV and HV were compared using Fisher's exact and Wilcoxon rank-sum test as appropriate (p = 0.05).The pudendal nerve and its rectal perineal and sensory branches coursed through the ischiorectal fossa, dorsomedial to the ischiatic spine. The pudendal nerve was not identified ultrasonographically, but the target plane was identified between the sacral transverse process, the ischiatic spine, the pelvic fascia and the rectum, and it was filled with dye solution. Both branches of the pudendal nerve were completely stained 75% and 87.5% in groups LV and HV, respectively (p = 1.00). The dorsal aspect of the sciatic nerve was partially stained in 37% of injections in group HV. Rectal or urethral puncture and intravascular injection were not observed.In cats, ultrasound-guided cranial transgluteal injection successfully stained the pudendal nerve in at least 75% of attempts, regardless of injectate volume. Group HV had a greater probability of sciatic nerve staining.}, number={2}, journal={VETERINARY ANAESTHESIA AND ANALGESIA}, author={Briley, Jessica D. and Keenihan, Erin K. and Mathews, Kyle G. and Chiavaccini, Ludovica}, year={2022}, month={Mar}, pages={189–196} } @article{downey_mathews_borst_2022, title={Cranial internal hemipelvectomy (iliectomy) with limb sparing for a dog with ilial chondrosarcoma: A case report}, volume={10}, ISSN={["2050-0904"]}, DOI={10.1002/ccr3.5262}, abstractNote={Abstract}, number={1}, journal={CLINICAL CASE REPORTS}, author={Downey, Amy C. and Mathews, Kyle G. and Borst, Luke}, year={2022}, month={Jan} } @article{vlaming_mathews_hash_keenihan_sommer_borst_vaden_2022, title={Creation of a Continent Urinary Bladder Reservoir Vascularized by Omentum as a Possible Surgical Option for Canine Trigonal/Urethral Urothelial Carcinoma}, volume={35}, ISSN={["1521-0553"]}, DOI={10.1080/08941939.2020.1864797}, abstractNote={Abstract Surgical procedures that maintain continence with minimal complication following resection of trigono-urethral urothelial carcinoma (UC) are limited in canines; therefore, palliative options are often pursued. A feasible tumor resection option may improve disease control and survival. The study’s objective was to evaluate a continent urine reservoir created from the urinary bladder body and vascularized solely by omentum. We hypothesized that a viable urine reservoir could be created, and staged omentalization would provide improved vascularity. Nine normal female Beagles were randomized to one of three groups. Group A urinary bladders were transected cranial to the ureteral papillae to create a closed bladder vesicle which was concomitantly omentalized. Group B underwent omentalization two weeks prior to vesicle creation. Based on Group A and B results, Group C underwent neoureterocystostomy and omentalization followed by neoreservoir formation and tube cystostomy 2 weeks later. Serial ultrasounds and histopathology confirmed adequate omental neovascularization in Groups B and C with continent Group C neoreservoirs maintained for 2 months. Some pylectasia and ureteral dilation was documented in all Group C dogs at variable timepoints. Progressive hydroureteronephrosis developed in 2/6 kidneys. Transient azotemia was noted in only 1 Group C dog, although all developed treatable urinary tract infections. The sample size is limited, and the efficacy of this technique in providing disease control for UC is unknown. However, this novel option could allow for primary UC resection while providing continence and limiting complications. Postoperative local or systemic adjuvant therapy, ultrasonographic neoreservoir monitoring, and BRAF analysis would be indicated.}, number={3}, journal={JOURNAL OF INVESTIGATIVE SURGERY}, author={Vlaming, Annemarieke and Mathews, Kyle G. and Hash, Jonathan A. and Keenihan, Erin K. and Sommer, Samantha and Borst, Luke and Vaden, Shelly L.}, year={2022}, month={Feb}, pages={481–495} } @article{vaden_mathews_yoo_williams_harris_secoura_robertson_gleason_reynolds_piedrahita_2022, title={The use of autologous skeletal muscle progenitor cells for adjunctive treatment of presumptive urethral sphincter mechanism incompetence in female dogs}, volume={8}, ISSN={["1939-1676"]}, url={http://dx.doi.org/10.1111/jvim.16505}, DOI={10.1111/jvim.16505}, abstractNote={Abstract}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, publisher={Wiley}, author={Vaden, Shelly L. and Mathews, Kyle G. and Yoo, James and Williams, James Koudy and Harris, Tonya and Secoura, Patty and Robertson, James and Gleason, Katherine L. and Reynolds, Hannah and Piedrahita, Jorge}, year={2022}, month={Aug} } @article{diamond_scharf_chiu_hash_mathews_2021, title={A randomized, prospective, comparative trial of a variable-angle versus fixed-angle endoscope for exploratory thoracoscopy in canine cadavers}, volume={50}, ISSN={["1532-950X"]}, DOI={10.1111/vsu.13449}, abstractNote={Abstract}, journal={VETERINARY SURGERY}, author={Diamond, Danielle M. and Scharf, Valery F. and Chiu, King Wa and Hash, Jonathan A. and Mathews, Kyle G.}, year={2021}, month={Jul}, pages={O17–O25} } @article{stoneburner_naughton_sherman_mathews_2021, title={Evaluation of a stimulus attenuation strategy to reduce stress in hospitalized cats}, volume={41}, ISSN={["1878-7517"]}, DOI={10.1016/j.jveb.2020.07.008}, abstractNote={Hospitalized cats are constantly exposed to unfamiliar and potentially anxiety-producing visual and auditory stimuli. Critical care areas may require heterospecific housing of dogs and cats. For boarding, many veterinary hospitals do not have feline-only wards. In all these conditions, cats are often housed in areas with high volumes of foot traffic and high levels of ambient noise. Attempts to reduce visual stimuli have been carried out. In veterinary hospitals, towels are often hung over the front of the cage. In the shelter environment, when a cardboard box “hide” was provided within the cage, a decrease in behavioral signs of stress has been documented. Unfortunately, these masking devices are not always a practical option in a medical setting because patients are not visible to the technical staff who need to monitor them on a frequent or continual basis. In addition, hiding structures may result in tangling of intravenous lines and monitoring devices. Boxes need to be discarded or sent home after each use; towels need to be disinfected. The aim of this study was to investigate the effect on cat behavior of a cage-front stimulus attenuation strategy that could be easily adapted to any cage. Thirty privately owned cats were individually placed in one of two conjoined cages (left and right), connected via a communicating tunnel inside an isolated study room. Each cage had a cage door. The left or right “start side” was randomly assigned. A previously recorded video of the sights and sounds of a veterinary inpatient ward was projected onto a screen directly in front of the cages for 70 minutes. During this time, starting at the same time each day for 6 consecutive days, each cat was video recorded the entire 70 minutes. On each day, cats could choose between 2 of the following cage front conditions in accordance with a predetermined protocol: unshielded cage front and cage front covered with either a clear plexiglass sheet, or an opaque plexiglass sheet. Time spent on each side was calculated from video recordings of the cats. Two cat-stress scores, established by Kessler and Turner's noninvasive Cat-Stress-Scoring system, were calculated based on each cat's behavior during the first and last 15 minutes of each observation period. The results revealed that, regardless of cage fronts being compared, cats with higher stress scores in the first 15 minutes of the observation spent significantly more time behind the cage front option that allowed for the greatest buffering of external stimuli. In addition, regardless of cage front, cats had a slight preference for the right-sided cage and for the cage they were placed in. Age, sex, and time of the day had no significant influence on cage front preference. These results indicate that cats that experienced elevated levels of stress in a veterinary hospital may benefit from the use of a simple stimulus abatement strategy to attenuate visual and auditory stimuli. Use of a plexiglass sheet at cage front still allows for visualization of the patient by the technical staff.}, journal={JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH}, author={Stoneburner, Regan M. and Naughton, Brian and Sherman, Barbara and Mathews, Kyle G.}, year={2021}, pages={33–38} } @article{zhang_lanzoni_hani_overi_cardinale_simpson_pitman_allen_yi_wang_et al._2021, title={Patch grafting, strategies for transplantation of organoids into solid organs such as liver}, volume={277}, ISSN={["1878-5905"]}, DOI={10.1016/j.biomaterials.2021.121067}, abstractNote={Epithelial cell therapies have been at an impasse because of inefficient methods of transplantation to solid organs. Patch grafting strategies were established enabling transplantation of ≥107th organoids/patch of porcine GFP+ biliary tree stem/progenitors into livers of wild type hosts. Grafts consisted of organoids embedded in soft (~100 Pa) hyaluronan hydrogels, both prepared in serum-free Kubota's Medium; placed against target sites; covered with a silk backing impregnated with more rigid hyaluronan hydrogels (~700 Pa); and use of the backing to tether grafts with sutures or glue to target sites. Hyaluronan coatings (~200-300 Pa) onto the serosal surface of the graft served to minimize adhesions with neighboring organs. The organ's clearance of hyaluronans enabled restoration of tissue-specific paracrine and systemic signaling, resulting in return of normal hepatic histology, with donor parenchymal cells uniformly integrated amidst host cells and that had differentiated to mature hepatocytes and cholangiocytes. Grafts containing donor mature hepatocytes, partnered with endothelia, and in the same graft biomaterials as for stem/progenitor organoids, did not engraft. Engraftment occurred if porcine liver-derived mesenchymal stem cells (MSCs) were co-transplanted with donor mature cells. RNA-seq analyses revealed that engraftment correlated with expression of matrix-metalloproteinases (MMPs), especially secreted isoforms that were found expressed strongly by organoids, less so by MSCs, and minimally, if at all, by adult cells. Engraftment with patch grafting strategies occurred without evidence of emboli or ectopic cell distribution. It was successful with stem/progenitor organoids or with cells with a source(s) of secreted MMP isoforms and offers significant potential for enabling cell therapies for solid organs.}, journal={BIOMATERIALS}, author={Zhang, Wencheng and Lanzoni, Giacomo and Hani, Homayoun and Overi, Diletta and Cardinale, Vincenzo and Simpson, Sean and Pitman, Wendy and Allen, Amanda and Yi, Xianwen and Wang, Xicheng and et al.}, year={2021}, month={Oct} } @article{su_huang_mathews_scharf_hu_li_frame_cores_dinh_daniele_et al._2020, title={Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs}, volume={6}, ISSN={["2373-9878"]}, DOI={10.1021/acsbiomaterials.0c00942}, abstractNote={The vascularized cardiac patch strategy is promising for ischemic heart repair after myocardial infarction (MI), but current fabrication processes are quite complicated. Vascularized cardiac patches that can promote concurrent restoration of both the myocardium and vasculature at the injured site in a large animal model remain elusive. The safety and therapeutic benefits of a cardiac stromal cell patch integrated with engineered biomimetic microvessels (BMVs) were determined for treating MI. By leveraging a microfluidic method employing hydrodynamic focusing, we constructed the endothelialized microvessels and then encapsulated them together with therapeutic cardiosphere-derived stromal cells (CSCs) in a fibrin gel to generate a prevascularized cardiac stromal cell patch (BMV-CSC patch). We showed that BMV-CSC patch transplantation significantly promoted cardiac function, reduced scar size, increased viable myocardial tissue, promoted neovascularization, and suppressed inflammation in rat and porcine MI models, demonstrating enhanced therapeutic efficacy compared to conventional cardiac stromal cell patches. BMV-CSC patches did not increase renal and hepatic toxicity or exhibit immunogenicity. We noted a significant increase in endogenous progenitor cell recruitment to the peri-infarct region of the porcine hearts treated with BMV-CSC patch as compared to those that received control treatments. These findings establish the BMV-CSC patch as a novel engineered-tissue therapeutic for ischemic tissue repair.}, number={11}, journal={ACS BIOMATERIALS SCIENCE & ENGINEERING}, author={Su, Teng and Huang, Ke and Mathews, Kyle G. and Scharf, Valery F. and Hu, Shiqi and Li, Zhenhua and Frame, Brianna N. and Cores, Jhon and Dinh, Phuong-Uyen and Daniele, Michael A. and et al.}, year={2020}, month={Nov}, pages={6309–6320} } @article{dickson_scharf_nelson_petrovitch_keenihan_mathews_2020, title={Computed tomography in two recumbencies aides in the identification of pulmonary bullae in dogs with spontaneous pneumothorax}, volume={61}, ISSN={["1740-8261"]}, DOI={10.1111/vru.12905}, abstractNote={Abstract}, number={6}, journal={VETERINARY RADIOLOGY & ULTRASOUND}, author={Dickson, Rachel and Scharf, Valery F. and Nelson, Nathan C. and Petrovitch, Nicholas and Keenihan, Erin K. and Mathews, Kyle G.}, year={2020}, month={Nov}, pages={641–648} } @article{carroll_mathews_2020, title={Ligation of the Maxillary Artery Prior to Caudal Maxillectomy in the Dog-A Description of the Technique, Retrospective Evaluation of Blood Loss, and Cadaveric Evaluation of Maxillary Artery Anatomy}, volume={7}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2020.588945}, abstractNote={Two different surgical techniques have been described for performing caudal maxillectomies in dogs including the intraoral (IO) and combined dorsolateral and intraoral (DL-IO) approach. Hemorrhage is the most common intraoperative complication reported during these procedures as maxillary arterial ligation is not performed until after all osteotomies and mobilization of tumor-bearing bone. The objectives of this study were to describe a modified approach for caudal maxillectomy in the dog involving preligation of the maxillary artery, to retrospectively evaluate the ability of this modified approach to limit hemorrhage in a cohort of 22 dogs, and to clarify the vascular anatomy of the maxillary artery and its branches in relation to associated nerves. Medical records were retrospectively reviewed for cases that had caudal maxillectomy via a combined approach (with or without preligation of the maxillary artery) from January 1, 2004 to December 31, 2019. Twenty-two cases were identified, six without, and 16 with arterial preligation, respectively. Osteotomies were completed with a high-speed handpiece and rotary bur (n = 18), or oscillating bone saw (n = 4). All six (100%) dogs in the traditional DL-IO group developed hypotension under general anesthesia. Four (67%) of these required intraoperative blood transfusions, one of which required an additional postoperative blood transfusion. In contrast, only one of 16 (6%) dogs in the modified DL-IO group required an intraoperative blood transfusion, and only three (19%) developed hypotension. Moreover, a significant association was detected between postoperative PCV and the two different surgical approaches (P = 0.021). These results demonstrate the effectiveness of preligation of the maxillary artery in preventing hemorrhage in caudal maxillectomies in dogs and this represents an improvement in outcome over previously reported studies. Decreased intraoperative hemorrhage may improve surgical exposure and decrease overall patient morbidity.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Carroll, Kenneth A. and Mathews, Kyle G.}, year={2020}, month={Nov} } @article{griffin_culp_giuffrida_ellis_tuohy_perry_gedney_lux_milovancev_wallace_et al._2020, title={Lower urinary tract transitional cell carcinoma in cats: Clinical findings, treatments, and outcomes in 118 cases}, volume={34}, ISSN={["1939-1676"]}, DOI={10.1111/jvim.15656}, abstractNote={Abstract}, number={1}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Griffin, Maureen A. and Culp, William T. N. and Giuffrida, Michelle A. and Ellis, Peter and Tuohy, Joanne and Perry, James A. and Gedney, Allison and Lux, Cassie N. and Milovancev, Milan and Wallace, Mandy L. and et al.}, year={2020}, month={Jan}, pages={274–282} } @article{rivas_seiler_robertson_ryu_mathews_2019, title={Ability of positive and negative contrast computed tomographic peritoneography to delineate canine liver lobe fissures}, volume={48}, ISSN={["1532-950X"]}, DOI={10.1111/vsu.13318}, abstractNote={Abstract}, number={8}, journal={VETERINARY SURGERY}, author={Rivas, Luis R. and Seiler, Gabriela S. and Robertson, Ian D. and Ryu, Hongyu and Mathews, Kyle G.}, year={2019}, month={Nov}, pages={1444–1449} } @article{schick_hayes_singh_mathews_higginbotham_sherwood_2019, title={Development and validation of a hemangiosarcoma likelihood prediction model in dogs presenting with spontaneous hemoabdomen: The HeLP score}, volume={29}, ISSN={["1476-4431"]}, DOI={10.1111/vec.12838}, abstractNote={Abstract}, number={3}, journal={JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE}, author={Schick, Ashley R. and Hayes, Galina M. and Singh, Ameet and Mathews, Kyle G. and Higginbotham, Mary Lynn and Sherwood, J. Matthew}, year={2019}, pages={239–245} } @article{putterman_trumpatori_mathews_2019, title={Successful vascularized jejunal patch graft to treat severe orad duodenal injury secondary to foreign body obstruction in a dog}, volume={48}, ISSN={["1532-950X"]}, DOI={10.1111/vsu.13174}, abstractNote={Abstract}, number={7}, journal={VETERINARY SURGERY}, author={Putterman, Allison B. and Trumpatori, Brian and Mathews, Kyle G.}, year={2019}, month={Oct}, pages={1338–1343} } @article{park_grimes_wallace_sterman_mankin_campbell_flannery_milovancev_mathews_schmiedt_2018, title={Lung lobe torsion in dogs: 52 cases (2005-2017)}, volume={47}, ISSN={["1532-950X"]}, DOI={10.1111/vsu.13108}, abstractNote={Abstract}, number={8}, journal={VETERINARY SURGERY}, author={Park, Karen M. and Grimes, Janet A. and Wallace, Mandy L. and Sterman, Allyson A. and Mankin, Kelley M. Thieman and Campbell, Bonnie G. and Flannery, Erin E. and Milovancev, Milan and Mathews, Kyle G. and Schmiedt, Chad W.}, year={2018}, month={Nov}, pages={1002–1008} } @article{gookin_mathews_cullen_seiler_2018, title={Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation}, volume={13}, ISSN={["1932-6203"]}, DOI={10.1371/journal.pone.0191076}, abstractNote={Mucocele formation is characterized by secretion of abnormally thick mucus by the gallbladder epithelium of dogs that may cause obstruction of the bile duct or rupture of the gallbladder. The disease is increasingly recognized and is associated with a high morbidity and mortality. The cause of gallbladder mucocele formation in dogs is unknown. There is a strong breed predisposition and affected dogs have a high incidence of concurrent endocrinopathy or hyperlipidemia. These observations suggest a significant influence of both genetic and metabolic factors on disease pathogenesis. In this study, we investigated a theory that mucocele formation is associated with a syndrome of metabolic disruption. We surmised that a global, untargeted metabolomics approach could provide unique insight into the systemic pathogenesis of gallbladder mucocele formation and identify specific compounds as candidate biomarkers or treatment targets. Moreover, concurrent examination of the serum and hepatic duct bile metabolome would enable the construction of mechanism-based theories or identification of specific compounds responsible for altered function of the gallbladder epithelium. Abnormalities observed in dogs with gallbladder mucocele formation, including a 33-fold decrease in serum adenosine 5’-monophosphate (AMP), lower quantities of precursors required for synthesis of energy transporting nucleotides, and increases in citric acid cycle intermediates, suggest excess metabolic energy and a carbon surplus. Altered quantities of compounds involved in protein translation and RNA turnover, together with accumulation of gamma-glutamylated and N-acetylated amino acids in serum suggest abnormal regulation of protein and amino acid metabolism. Increases in lathosterol and 7α-hydroxycholesterol suggest a primary increase in cholesterol synthesis and diversion to bile acid formation. A number of specific biomarker compounds were identified for their ability to distinguish between control dogs and those that formed a gallbladder mucocele. Particularly noteworthy was a significant decrease in quantity of biologically active compounds that stimulate biliary ductal fluid secretion including adenosine, cAMP, taurolithocholic acid, and taurocholic acid. These findings support the presence of significant metabolic disruption in dogs with mucocele formation. A targeted, quantitative analysis of the identified serum biomarkers is warranted to determine their utility for diagnosis of this disease. Finally, repletion of compounds whose biological activity normally promotes biliary ductal secretion should be examined for any therapeutic impact for resolution or prevention of mucocele formation.}, number={1}, journal={PLOS ONE}, author={Gookin, Jody L. and Mathews, Kyle G. and Cullen, John and Seiler, Gabriela}, year={2018}, month={Jan} } @article{phillips_ellison_mathews_aronson_schmiedt_robello_selmic_gregory_2018, title={Validation of a model of feline ureteral obstruction as a tool for teaching microsurgery to veterinary surgeons}, volume={47}, ISSN={["1532-950X"]}, DOI={10.1111/vsu.12769}, abstractNote={Abstract}, number={3}, journal={VETERINARY SURGERY}, author={Phillips, Heidi and Ellison, Gary W. and Mathews, Kyle G. and Aronson, Lillian R. and Schmiedt, Chad W. and Robello, Gil and Selmic, Laura E. and Gregory, Clare R.}, year={2018}, month={Apr}, pages={357–366} } @article{paradise_mathews_cohen_2017, title={IMAGING DIAGNOSIS-USE OF RADIOGRAPHY, COMPUTED TOMOGRAPHY, AND ENDOSCOPY IN THE DIAGNOSIS OF ESOPHAGEAL PERFORATION BY AN EXTRA-LUMINAL TRACHEAL RING PROSTHESIS IN A GOLDEN RETRIEVER}, volume={58}, ISSN={["1740-8261"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84979243547&partnerID=MN8TOARS}, DOI={10.1111/vru.12400}, abstractNote={A 6‐year‐old neutered male, Golden retriever presented with regurgitation and excitement‐induced coughing. Two years prior, extra‐thoracic tracheal collapse was diagnosed and extra‐luminal tracheal ring prostheses were placed. Radiographs at presentation showed mineralized and undulant cervical tracheal cartilages. A dorsally broad‐based soft tissue opacity bulged into the caudal cervical tracheal lumen. Esophageal dysmotility and barium accumulation were identified at this level on contrast esophography. Computed tomography showed migration of a prosthetic tracheal ring, resulting in perforation of the esophagus. Hair, foreign material, and dynamic tracheal narrowing were identified on esophagoscopy and tracheoscopy, respectively. Esophagostomy and foreign body removal were performed.}, number={4}, journal={VETERINARY RADIOLOGY & ULTRASOUND}, author={Paradise, Hayley and Mathews, Kyle G. and Cohen, Eli B.}, year={2017}, pages={E37–E41} } @article{risselada_mathews_griffith_2016, title={Effect of feline skin specimen preparation on postexcision and postfixation tissue shrinkage}, volume={18}, ISSN={["1532-2750"]}, DOI={10.1177/1098612x15602951}, abstractNote={Objectives This study was performed to assess skin–muscle–fascia specimen shrinkage and donor site changes, and to compare three techniques of specimen preparation for their effect on specimen shrinkage postexcision and after formalin fixation in feline cadaveric specimens. }, number={12}, journal={JOURNAL OF FELINE MEDICINE AND SURGERY}, author={Risselada, Marije and Mathews, Kyle G. and Griffith, Emily}, year={2016}, month={Dec}, pages={970–975} } @article{risselada_mathews_griffith_2016, title={The effect of specimen preparation on post-excision and post-fixation dimensions, translation, and distortion of canine cadaver skin-muscle-fascia specimens}, volume={45}, DOI={10.1111/vsu.12481}, abstractNote={ObjectiveTo assess the effect of various tissue apposition techniques on specimens after formalin fixation, and to assess canine cadaveric composite skin‐muscle‐fascia specimen changes after excision without and with addition of a tumor model.}, number={5}, journal={Veterinary Surgery}, author={Risselada, M. and Mathews, K. G. and Griffith, E.}, year={2016}, pages={563–570} } @article{bray_worley_henderson_boston_mathews_romanelli_bacon_liptak_scase_2014, title={Hemipelvectomy: Outcome in 84 Dogs and 16 Cats. A Veterinary Society of Surgical Oncology Retrospective Study}, volume={43}, ISSN={["1532-950X"]}, DOI={10.1111/j.1532-950x.2013.12080.x}, abstractNote={ObjectiveTo report clinical findings, perioperative complications and long‐term outcome in dogs and cats that had hemipelvectomy surgery for treatment of neoplasia.}, number={1}, journal={VETERINARY SURGERY}, author={Bray, Jonathan P. and Worley, Deanna R. and Henderson, Ralph A. and Boston, Sarah E. and Mathews, Kyle G. and Romanelli, Giorgio and Bacon, Nicholas J. and Liptak, Julius M. and Scase, Tim J.}, year={2014}, month={Jan}, pages={27–37} } @article{balakrishnan_pritchard_ericson_grindem_phillips_jennings_mathews_tran_birkenheuer_breitschwerdt_et al._2014, title={Prostatitis, Steatitis, and Diarrhea in a Dog following Presumptive Flea-Borne Transmission of Bartonella henselae}, volume={52}, ISSN={0095-1137 1098-660X}, url={http://dx.doi.org/10.1128/JCM.00942-14}, DOI={10.1128/jcm.00942-14}, abstractNote={ABSTRACT}, number={9}, journal={Journal of Clinical Microbiology}, publisher={American Society for Microbiology}, author={Balakrishnan, N. and Pritchard, J. and Ericson, M. and Grindem, C. and Phillips, K. and Jennings, S. and Mathews, K. and Tran, H. and Birkenheuer, A. J. and Breitschwerdt, Edward and et al.}, editor={Munson, E.Editor}, year={2014}, month={Jun}, pages={3447–3452} } @article{rowe_mathews_linder_tate_2014, title={The Effect of Photodynamic Therapy on Cisterna Chyli Patency in Rats}, volume={43}, ISSN={["1532-950X"]}, DOI={10.1111/j.1532-950x.2014.12222.x}, abstractNote={ObjectiveTo radiographically and histologically evaluate the effects of photodynamic therapy on the cisterna chyli in rats.}, number={6}, journal={VETERINARY SURGERY}, author={Rowe, Eric A. and Mathews, Kyle G. and Linder, Keith E. and Tate, Lloyd P.}, year={2014}, month={Aug}, pages={642–649} } @article{stern_tou_barker_hill_lodge_mathews_keene_2013, title={Hybrid cutting balloon dilatation for treatment of cor triatriatum sinister in a cat}, volume={15}, ISSN={["1875-0834"]}, DOI={10.1016/j.jvc.2013.03.001}, abstractNote={A hybrid surgical approach and balloon dilatation were performed successfully in a cat with cor triatriatum sinister and clinical signs of congestive heart failure. Left lateral thoracotomy was used to access the heart and cutting balloon followed by standard balloon dilatation were utilized to dilate the perforation in the anomalous left atrial membrane. Clinical signs resolved completely after dilation of the anomalous left atrial membrane. Based upon the outcome of this case, balloon dilatation appears to be a viable treatment option for cats affected with cor triatriatum sinister.}, number={3}, journal={JOURNAL OF VETERINARY CARDIOLOGY}, author={Stern, Joshua A. and Tou, Sandra P. and Barker, Piers C. A. and Hill, Kevin D. and Lodge, Andrew J. and Mathews, Kyle G. and Keene, Bruce W.}, year={2013}, month={Sep}, pages={205–210} } @article{visser_keene_mathews_browne_chanoit_2013, title={Outcomes and Complications Associated With Epicardial Pacemakers in 28 Dogs and 5 Cats}, volume={42}, ISSN={["1532-950X"]}, DOI={10.1111/j.1532-950x.2013.12020.x}, abstractNote={Abstract}, number={5}, journal={VETERINARY SURGERY}, author={Visser, Lance C. and Keene, Bruce W. and Mathews, Kyle G. and Browne, William J. and Chanoit, Guillaume}, year={2013}, month={Jun}, pages={544–550} } @article{chanoit_mathews_keene_small_linder_2012, title={Surgical treatment of a pulmonary artery vascular hamartoma in a dog}, volume={240}, ISSN={0003-1488}, url={http://dx.doi.org/10.2460/javma.240.7.858}, DOI={10.2460/javma.240.7.858}, abstractNote={Abstract}, number={7}, journal={Journal of the American Veterinary Medical Association}, publisher={American Veterinary Medical Association (AVMA)}, author={Chanoit, Guillaume and Mathews, Kyle G. and Keene, Bruce W. and Small, Merrilee T. and Linder, Keith}, year={2012}, month={Apr}, pages={858–862} } @article{szabo_jermyn_neel_mathews_2011, title={Evaluation of Postceliotomy Peritoneal Drain Fluid Volume, Cytology, and Blood-to-Peritoneal Fluid Lactate and Glucose Differences in Normal Dogs}, volume={40}, ISSN={["1532-950X"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-79957929895&partnerID=MN8TOARS}, DOI={10.1111/j.1532-950x.2011.00799.x}, abstractNote={Objective: To describe peritoneal drain fluid volume, fluid cytology, and blood‐to‐peritoneal fluid lactate and glucose concentration differences after exploratory celiotomy in normal dogs.}, number={4}, journal={VETERINARY SURGERY}, author={Szabo, Stephanie D. and Jermyn, Kieri and Neel, Jennifer and Mathews, Kyle G.}, year={2011}, month={Jun}, pages={444–449} } @article{trumpatori_carter_hash_davidson_mathews_roe_lascelles_2010, title={Evaluation of a Midhumeral Block of the Radial, Ulnar, Musculocutaneous and Median (RUMM Block) Nerves for Analgesia of the Distal Aspect of the Thoracic Limb in Dogs}, volume={39}, ISSN={0161-3499}, url={http://dx.doi.org/10.1111/j.1532-950x.2010.00712.x}, DOI={10.1111/j.1532-950x.2010.00712.x}, abstractNote={OBJECTIVE To evaluate a technique for midhumeral peripheral nerve blockade in the dog. STUDY DESIGN Cadaveric technique development; in vivo placebo-controlled, prospective crossover study. ANIMALS Canine cadavers (n=38) and 8 clinically healthy, adult hound dogs. METHODS A technique for peripheral block of the radial, ulnar, musculocutaneous, and median nerves (RUMM block) was evaluated using cadaver limbs. Eight purpose-bred, research dogs were anesthetized; a RUMM block was performed on each thoracic limb. One limb from each dog randomly received 0.5% bupivacaine and the opposite limb was assigned to receive sterile saline solution as a control. After recovery from anesthesia, skin sensation at selected dermatomes was evaluated for 24 hours using a mechanical stimulus. Weight-bearing, conscious proprioception, and withdrawal reflex were also evaluated. One month after initial testing, each dog was reanesthetized and each limb received the opposite treatment. RESULTS Sensory thresholds were significantly increased over baseline measurements when compared with control limbs for all nerves. Complete sensory block was achieved in radial (15/16), ulnar (3/16), musculocutaneous (8/16), and median (11/16) nerves, using a mechanical stimulus of analgesia. Complete simultaneous block of all nerves was only obtained in 1 of 16 limbs. CONCLUSION RUMM block resulted in desensitization of the skin in the associated dermatomes for 4-10 hours. Complete sensory block of the dermatomes supplied by the radial nerve was most consistent. CLINICAL RELEVANCE RUMM block may be an effective technique to provide adjunctive analgesia for dogs undergoing surgery of the distal aspect of the thoracic limb.}, number={7}, journal={Veterinary Surgery}, publisher={Wiley}, author={Trumpatori, Brian J. and Carter, Jennifer E. and Hash, Jon and Davidson, Gigi S. and Mathews, Kyle G. and Roe, Simon C. and Lascelles, B. Duncan X.}, year={2010}, month={Jul}, pages={785–796} } @article{mathews_riley_lascelles_dernell_2010, title={Preparation of canine and feline cadavers for surgical laboratories}, volume={39}, ISSN={0161-3499 1532-950X}, url={http://dx.doi.org/10.1111/j.1532-950X.2009.00586.x}, DOI={10.1111/j.1532-950x.2009.00586.x}, abstractNote={CANINE AND feline cadavers are frequently used for teaching surgical skills to veterinarians and veterinary students. Use of cadavers reduces the need to use live animals in teaching laboratories, while giving the participant a more realistic experience than if models alone were used. Cadavers obtained from cooperating shelters or client-based donation programs allow use of tissues that would otherwise be disposed. Ethically sourced cadavers also eliminate costs associated with purchasing formalin-fixed specimens from commercial sources, and eliminate exposure of laboratory instructors and participants to formaldehyde; however, whole nonfixed cadavers undergo autolysis, which can be objectionable to participants, especially for reconstructive laboratories involving entry into the thoracic or abdominal cavities. We have used a technique of cadaveric evisceration and freezing shortly after death to eliminate these concerns. Cadavers prepared in this manner are suitable for a wide variety of oncologic, orthopedic, and other laboratories. Viscera can also be harvested, washed, and frozen for future use.}, number={2}, journal={Vet Surg}, publisher={Wiley}, author={Mathews, K.G. and Riley, K. and Lascelles, B.D. and Dernell, W.S.}, year={2010}, month={Feb}, pages={224–5} } @article{mathews_linder_davidson_goldman_papich_2009, title={Assessment of clotrimazole gels for in vitro stability and in vivo retention in the frontal sinus of dogs}, volume={70}, ISSN={["0002-9645"]}, DOI={10.2460/ajvr.70.5.640}, abstractNote={Abstract}, number={5}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Mathews, Kyle G. and Linder, Keith E. and Davidson, Gigi S. and Goldman, Rebecca B. and Papich, Mark G.}, year={2009}, month={May}, pages={640–647} } @article{arnold_mathews_roe_mente_seaboch_2009, title={Biomechanical Comparison of Four Soft Tissue Replacement Materials: An In Vitro Evaluation of Single and Multilaminate Porcine Small Intestinal Submucosa, Canine Fascia Lata, and Polypropylene Mesh}, volume={38}, ISSN={["1532-950X"]}, DOI={10.1111/j.1532-950X.2009.00577.x}, abstractNote={Objective— To compare mechanical performance of 4 soft tissue replacement materials.}, number={7}, journal={VETERINARY SURGERY}, author={Arnold, Gregory A. and Mathews, Kyle G. and Roe, Simon and Mente, Peter and Seaboch, Tim}, year={2009}, month={Oct}, pages={834–844} } @article{mitsui_mathews_linder_kruse_roe_2009, title={Effects of fascial abrasion, fasciotomy, and fascial excision on cutaneous wound healing in cats}, volume={70}, ISSN={0002-9645}, url={http://dx.doi.org/10.2460/ajvr.70.4.532}, DOI={10.2460/ajvr.70.4.532}, abstractNote={Abstract}, number={4}, journal={American Journal of Veterinary Research}, publisher={American Veterinary Medical Association (AVMA)}, author={Mitsui, Akiko and Mathews, Kyle G. and Linder, Keith E. and Kruse, Meghan A. and Roe, Simon C.}, year={2009}, month={Apr}, pages={532–538} } @article{cruse_vaden_mathews_hill_robertson_2009, title={Use of Computed Tomography (CT) Scanning and Colorectal New Methylene Blue Infusion in Evaluation of an English Bulldog with a Rectourethral Fistula}, volume={23}, ISSN={["1939-1676"]}, DOI={10.1111/j.1939-1676.2009.0320.x}, abstractNote={Rectourethral fistulas are uncommonly reported in veterinary medicine having only been reported in 13 dogs.1-11 Seven were English Bulldogs and 3 were Miniature Poodles. The diagnosis of a rectourethral fistula is challenging. Survey radiography, double contrast cystography, pneumocystography, and colonoscopy are unreliable modalities for the diagnosis of a fistula.6-9 Four of the 13 previously reported dogs required more than 1 contrast imaging study to confirm the presence of a rectourethral fistula.2, 4, 7, 9 In 1 affected dog, 4 contrast cystourethrograms were performed over a 7-year period before identifying the fistula.4 To date, no case report in the veterinary literature has described use of computed tomography (CT) scanning or new methylene bluea as alternate methods for the diagnosis of rectourethral fistulas. Most rectourethral fistulas in people are acquired secondary to trauma, pelvic surgery, inflammatory bowel disease, or malignancy.12 The diagnosis can be made by witnessing fecaluria or by using advanced diagnostic procedures. Some physicians prefer the aid of contrast cystourethrography13, 14 whereas others have reported the usefulness of CT scanning for both establishing the diagnosis and for surgical planning.15 CT scanning for the detection of anorectal anomalies was first described in infants and has since become a valuable diagnostic tool.16, 17 To date, the most commonly utilized diagnostic techniques in people include cystourethroscopy, advanced imaging such as CT scanning or magnetic resonance imaging, and radiographic contrast imaging.13-19 This report describes the successful use of CT and cystourethrography to diagnose a rectourethral fistula in an English Bulldog. Whereas cystourethrography was used to determine that a fistula was present, the exact anatomic location could not be verified. In contrast, the CT scan was very useful in establishing an accurate anatomic localization of the fistula and surgical planning for repair. In addition, this report describes a technique of colorectal infusion of new methylene blue during cystourethroscopy, which may be a useful adjunctive procedure to verify the presence of an abnormal communication between the urinary and gastrointestinal tracts. A 1-year-old 26.1 kg male castrated English Bulldog was presented to the North Carolina State University Veterinary Teaching Hospital (NCSU-VTH) with a 4-month history of recurrent urinary tract infections. The owner reported pollakiuria, stranguria, and hematuria. Upon initial presentation to the referring veterinarian, gross hematuria, bacteriuria, and pyuria were detected in a voided urine sample. Clinical signs transiently abated after treatment with amoxicillin-clavulanic acidb (15 mg/kg PO q12h for 14 days). Approximately 21 days after initial presentation, a urine sample collected by cystocentesis grew Escherichia coli and Proteus mirabilis that were susceptible to amoxicillin-clavulanic acid. Although abdominal radiographs were unremarkable, small cystoliths, bilateral renal mineralization, and a thickened bladder wall were detected on abdominal ultrasonography. Urinary crystalline material analyzed by the Minnesota Urolith Centerc was identified as magnesium ammonium phosphate. Ninety days after initial presentation, urinalysis of a catheterized sample indicated hematuria and bacteriuria. Microbial culture of the same sample resulted in growth of Klebsiella pneumoniae and E. coli. Based on susceptibility test results, the dog was treated with amoxicillin-clavulanic acid (14 mg/kg PO q12h for 6 weeks) and marbofloxacin (8 mg/kg PO q24h for 6 weeks). At presentation to the NCSU-VTH, no abnormalities were detected during physical examination. Results of a CBC and biochemical profile were unremarkable. Urinalysis of a sample collected by cystocentesis indicated urine specific gravity of 1.014, urine pH of 8.0, trace bacteruria, and 0–5 white blood cells per high-power field. An aliquot of the same urine sample was submitted for microbial culture and resulted in light growth of a resistant strain of Enterococcus faecium. Abdominal ultrasonography identified a thickened irregular urinary bladder wall and small cystic calculi. A hyperemic bladder and urethral mucosa consistent with urinary tract inflammation, as well as particulate matter were identified during cystourethroscopy. Analysis of the particulate matter by the Minnesota Urolith Center identified a gelatinous material not consistent with urinary calculi, but rather a conglomerate of fungal hyphae, bacterial rods and cocci, and cellular material. A positive contrast retrograde urethrocystogram was performed after cystourethroscopy with fluoroscopic guidance. Approximately 20 mL of iohexold (240 mg/mL diluted with 0.9% saline to a concentration of 120 mg/mL) was infused over a 3–5-minute period through an 8-french Foley catheter placed into the urethra. The catheter balloon was positioned and inflated approximately 1 in. distal to the ischiatic tuberosity. At the level of the prostate gland, contrast medium exited the urethra within a tract that extended caudally and emptied into the rectum, indicating the presence of a rectourethral fistula. The dog represented 7 days later for surgical correction of the rectourethral fistula. Based on the owner's desire for a minimally invasive approach, initially laparoscopy was performed. Laparoscopic exploration of the area dorsal to the urethra failed to identify an obvious fistula, and the procedure was converted to a standard ventral midline laparotomy. A red rubber urinary catheter was placed to fill the bladder with saline. Pressure was applied to the urinary bladder while digitally obstructing the urethra in an attempt to force saline into the fistula as an aid to its identification. No abnormal tissue could be identified. Because of the potential risk to neurovascular structures associated with further dissection, and the potential morbidity associated with pelvic osteotomies, the decision was made to recover the animal from anesthesia and attempt to further characterize the anatomic location of the fistula with additional diagnostic techniques at a future date. The dog was discharged from the hospital the next day with instructions to be given amoxicillin-clavulanic acid (14 mg/kg PO q12h for 10 days). Thirty days after the initial surgery, colonoscopy was performed using a 1,680 mm length flexible Olympuse colonoscope with an outer diameter of 12.2 mm in an attempt to locate the fistula. Patient preparation consisted of a combination of a 24-hour fast, oral polyethylene glycol solution,f and warm water enemas. During colonoscopy, many small raised areas consistent with lymphoid follicles were noted, but a fistula was not visualized. After colonoscopy, cystourethroscopy was performed with a 600 mm length flexible Storzg cystoscope with an outer diameter of 3.8 mm. In another attempt to identify the location of the fistula, new methylene blue was instilled into the colon during urethroscopsy. A 24-french Foley catheter was advanced approximately 10 in. aborally into the descending colon. A 2nd 24-french Foley catheter was positioned in at the level of the rectum. The balloon of each catheter was filled with 30 mm 0.9% saline. Thirty milliliters of new methylene blue was diluted 1 : 1 with 0.9% saline to a total volume of 60 mm and instilled through the distal catheter, over a period of 10–15 seconds, into the space between the 2 catheter balloons where the fistula was believed to be located. The urine in the urethra became blue-tinged within minutes confirming translocation of the new methylene blue from the colon into the urethra. At the level of the prostatic urethra, several small depressions of the urethral mucosa were noted (Fig 1). Although the largest of these depressions was believed to be associated with the fistula, there was no definitive evidence of new methylene blue entering the urethra through these areas. Thus, the new methylene blue was useful in confirming the presence of the fistula but did not identify its location. (A) Cystourethroscopy before new methylene blue infusion. There are several small depressions and one larger depression in the urethral mucosa. The larger depression is believed to be associated with the fistula. (B) Cystourethroscopy after new methylene blue infusion. The urine became blue-tinged consistent with passage of new methylene blue from the colon to the urethra. 101 × 76 mm (300 × 300 DPI). After cystourethroscopy, CTh scanning was performed in conjunction with a positive contrast retrograde urethrogram. Iohexol was diluted and administered at a concentration of 80 mg of iodine per milliliter through an 8-french Foley catheter placed in the urethra. Contrast medium was present within the urethra, urinary bladder, colon, and rectum. A fistulous tract oriented in a caudodorsal direction connecting the urethra to the rectum immediately caudal to the prostate was readily apparent (2, 3). Retrograde urography. One millimeter transverse image of intrapelvic urethra and rectum immediately cranial to the coxofemoral joints. The white arrow is the urethra. The black arrow is the fistulous tract extending caudodorsally on the right. Contrast medium within the terminal colon is readily apparent. 101 × 76 mm (300 × 300 DPI). Sagittal CT reconstruction. There is contrast medium within the tract between the urethra and rectum. White arrows are urethra. Black arrows are the fistulous tract. 101 × 76 mm (300 × 300 DPI). The CT scan allowed more accurate anatomic localization and the dog was returned to surgery in a 2nd attempt to ligate the fistula, this time using a perineal approach. A lumen was identified and catheterized with an 8-french red rubber catheter directed toward the urethra. Both the rectal end and urethral end of the fistula were ligated and oversewn. A total of 6 urine samples were obtained by cystocentesis and submitted for microbial culture over the next year while the dog was not receiving antibiotics. All were negative for bacterial growth. A 1-year follow-up conversation with the owner indicated that the dog no longer had any clinical signs related to the lower urinary tract. Rectourethral fistulas are persistent communications between the rectum and urethra. Of the 13 dogs reported with rectourethral fistulas, 11 were suspected to be congenital in nature.2-10 The exact embryologic formation of a rectourethral fistula is not known. During normal canine development, the urorectal fold contacts the cloacal membrane, which subsequently ruptures, resulting in separate urogenital and digestive orifices. The caudal portion of the urogenital orifice further differentiates into the urethra. Fistulas can occur either secondary to failure of the urorectal septum to separate the cloaca into ventral urethrovesical and dorsal rectal segments or due to rupture of the cloacal membrane before contacting the urorectal fold.3, 20 Additionally, infectious or inflammatory processes can occur in utero that could lead to perforation of the rectum and subsequent fistula formation.10 In both humans and dogs with rectourethral fistulas, the most common presenting clinical signs are caused by recurrent cystitis and include dysuria, hematuria, pollakiuria, or stranguria.3-10, 13, 21 Ten of the 13 canine rectourethral fistulas reports included aerobic urine culture results. Aerobic culture yielded growth of ≥ 2 bacterial species in 6 of these reports.2, 4, 6, 8-10 The most common bacterial organisms reported were E. coli and Proteus spp.1-10 Neither of the dogs with acquired fistulas had positive aerobic urine cultures.1, 11 In 1 study of dogs with recurrent or persistent urinary tract infections, approximately 25% of the urine specimens yielded the growth of ≥ 2 bacterial species by aerobic bacterial culture, as was noted in the dog of this report.12 The presence of multiple organisms on urine culture specimen may raise clinical suspicion of systemic immunocompromise, anatomic defects along the lower urinary tract, or external contamination of the urine sample. Rectourethral fistula is an uncommon anatomic defect that can lead to recurrent or persistent urinary tract infections. In this dog, the fistula was oriented in a cranioventral to caudodorsal direction running between the prostatic urethra and the caudoventral rectum. This orientation made identification of the fistula at surgery difficult because it was closely associated with the dorsal aspect of the urethra cranioventrally. After CT scan, a different surgical approach was used and resulted in successful repair of the fistula. To the authors' knowledge, this is the 1st report of CT scanning and colorectal infusion of new methylene blue during cystourethroscopy for the evaluation of rectourethral fistulas in a dog, although these techniques have been described in humans.18, 22 Since evaluating the dog of this case report, we have performed colorectal infusion of new methylene blue in 2 additional young dogs that were presented for evaluation of recurrent urinary tract infections. Neither of these dogs had any discoloration of the urine after infusion with new methylene blue nor did they have fistulas. The infusion is an easily performed technique that can be incorporated into cystourethroscopy to identify if there is an abnormal communication between the urethra and rectum or colon. Specific patient preparation for this technique includes enemas to evacuate the descending colon and the placement of 2 Foley catheters. Although the location of the fistula may not be readily identifiable, a color change of the urine indicates the presence of an abnormal communication between the urinary and gastrointestinal tracts. In the dog of this report, advanced imaging was needed for precise anatomical localization. CT scanning may be useful to accurately localize the fistula, which can aid surgical planning and successful repair. aNew Methylene Blue 1% solution, Taylor Pharmaceuticals, Decatur, IL bClavamox; Pfizer Animal Health, Exton, PA cUniversity of Minnesota, St Paul, MN dOmnipaque 240 mg/mL, GE Healthcare, Princeton, NJ eOlympus America Inc, Center Valley, PA fGoLYTELY (PEG-3350 and electrolytes), Braintree Laboratories Inc, Braintree, MA gKarl Storz Endoscope, Roswell, GA hSiemens Sensation 16, Siemens Medical Solutions USA Inc, Malvern, PA This study was not supported by a grant.}, number={4}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Cruse, A. M. and Vaden, S. L. and Mathews, K. G. and Hill, T. L. and Robertson, I. D.}, year={2009}, pages={931–934} } @article{vince_lascelles_mathews_altier_roe_2008, title={Evaluation of wraps covering the distal aspect of pelvic limbs for prevention of bacterial strike-through in an ex vivo canine model}, volume={37}, ISSN={["0161-3499"]}, url={https://dx.doi.org/10.1111/j.1532-950X.2008.00395.x}, DOI={10.1111/j.1532-950X.2008.00395.x}, abstractNote={Objective—To determine differences in bacterial strike‐through for materials commonly used to cover the distal aspect of the pelvic limb during operative site preparation.}, number={4}, journal={VETERINARY SURGERY}, author={Vince, Kent J. and Lascelles, B. Duncan X. and Mathews, Kyle G. and Altier, Craig and Roe, Simon C.}, year={2008}, month={Jun}, pages={406–411} } @article{trumpatori_geissler_mathews_2007, title={Parotid duct sialolithiasis in a dog}, volume={43}, ISSN={["1547-3317"]}, DOI={10.5326/0430045}, abstractNote={Computed tomography was used to evaluate a 7-year-old English bulldog with a history of facial swelling and to aid in the diagnosis of parotid duct sialolithiasis. Removal of the sialolith with repair of the duct was not possible because of ductal fibrosis. Histological evaluation revealed glandular atrophy and fibrosis with lymphoplasmacytic inflammation. The parotid duct was ulcerated and fibrotic, with a mixed inflammatory infiltrate. Surgical excision of the parotid duct and salivary gland was curative.}, number={1}, journal={JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION}, author={Trumpatori, Brian J. and Geissler, Kyleigh and Mathews, Kyle G.}, year={2007}, pages={45–51} } @article{fujii_keene_mathews_atkins_defrancesco_hardie_wakao_2006, title={Coil occlusion of residual shunts after surgical closure of patent ductus arteriosus}, volume={35}, ISSN={["0161-3499"]}, DOI={10.1111/j.1532-950X.2006.00222.x}, abstractNote={Objective— To describe use of coil embolization to occlude residual flow through a patent ductus arteriosus (PDA) after incomplete surgical ligation.}, number={8}, journal={VETERINARY SURGERY}, author={Fujii, Yoko and Keene, Bruce W. and Mathews, Kyle G. and Atkins, Clarke E. and Defrancesco, Teresa C. and Hardie, Elizabeth M. and Wakao, Yoshito}, year={2006}, month={Dec}, pages={781–785} } @article{davis_roe_mathews_mente_2006, title={Median sternotomy closure in dogs: A mechanical comparison of technique stability}, volume={35}, ISSN={["0161-3499"]}, DOI={10.1111/j.1532-950X.2006.00143.x}, abstractNote={Objective— To evaluate the mechanical properties of canine median sternotomy closure using double‐loop cerclage compared with other commonly used cerclage sternotomy closure patterns.}, number={3}, journal={VETERINARY SURGERY}, author={Davis, KM and Roe, SC and Mathews, KG and Mente, PL}, year={2006}, month={Apr}, pages={271–277} } @article{mathews_hardie_murphy_2006, title={Subtotal Ear Canal Ablation in 18 Dogs and One Cat With Minimal Distal Ear Canal Pathology}, volume={42}, ISSN={0587-2871 1547-3317}, url={http://dx.doi.org/10.5326/0420371}, DOI={10.5326/0420371}, abstractNote={A modified technique for performing total ear canal ablations is described. This technique requires less dissection than the standard technique and maintains a portion of the distal vertical ear canal. Subtotal ear canal ablations were performed in 18 dogs and one cat for the treatment of otitis externa or masses of the horizontal ear canal. Animals with otitis externa had minimal involvement of the distal ear canal. Dermatological problems associated with the remaining ear canal and pinnae occurred in eight animals and resolved with medical management. Normal ear carriage was maintained in all animals with erect ears. Further investigation is required before the procedure can be recommended as a treatment for otitis externa not caused by masses or anatomical abnormalities of the horizontal ear canal in dogs with pendulous ears.}, number={5}, journal={Journal of the American Animal Hospital Association}, publisher={American Animal Hospital Association}, author={Mathews, Kyle G. and Hardie, Elizabeth M. and Murphy, K. Marcia}, year={2006}, month={Sep}, pages={371–380} } @article{kyles_hardie_wooden_adin_stone_gregory_mathews_cowgill_vaden_nyland_et al._2005, title={Clinical, clinicopathologic, radiographic, and ultrasonographic abnormalities in cats with ureteral calculi: 163 cases (1984-2002)}, volume={226}, ISSN={["0003-1488"]}, DOI={10.2460/javma.2005.226.932}, abstractNote={Abstract}, number={6}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Kyles, AE and Hardie, EM and Wooden, BG and Adin, CA and Stone, EA and Gregory, CR and Mathews, KG and Cowgill, LD and Vaden, S and Nyland, TG and et al.}, year={2005}, month={Mar}, pages={932–936} } @article{kyles_hardie_wooden_adin_stone_gregory_mathews_cowgill_vaden_nyland_et al._2005, title={Management and outcome of cats with ureteral calculi: 153 cases (1984-2002)}, volume={226}, ISSN={["0003-1488"]}, DOI={10.2460/javma.2005.226.937}, abstractNote={Abstract}, number={6}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Kyles, AE and Hardie, EM and Wooden, BG and Adin, CA and Stone, EA and Gregory, CR and Mathews, KG and Cowgill, LD and Vaden, S and Nyland, TG and et al.}, year={2005}, month={Mar}, pages={937–944} } @article{wang_mathews_robertson_stebbins_trumpatori_2005, title={The effects of patient positioning and slice selection on canine acetabular angle assessment with computed tomography}, volume={46}, ISSN={1058-8183 1740-8261}, url={http://dx.doi.org/10.1111/j.1740-8261.2005.00007.x}, DOI={10.1111/j.1740-8261.2005.00007.x}, abstractNote={Acetabular angles (AAs) and dorsal acetabular rim angles acquired by computed tomographic (CT) imaging have been used to assess patient response to juvenile pubic symphysiodesis surgery. The purpose of this study was to evaluate the effects of patient positioning and slice selection on these angles, and an attempt was made to devise a repeatable method of measuring these angles that would eliminate positioning effects. We found significant variation in AAs with small differences in pelvic tilt and slice selection. Dorsal acetabular rim angles were not affected. As a result of positioning differences from one CT study to the next, every attempt should be made to standardize pelvic tilt, or eliminate its effect on AAs by standardizing gantry angle in relation to an anatomic landmark that will not change over time. The floor of the sacral vertebral canal may be a reasonable landmark for this purpose and deserves further study.}, number={1}, journal={Veterinary Radiology