Kymberly Mae Gowdy

Works (5)

Updated: August 5th, 2023 09:50

2021 journal article

Scavenger Receptor BI Attenuates IL-17A-Dependent Neutrophilic Inflammation in Asthma

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 64(6), 698–708.

By: S. Reece *, S. Varikuti*, B. Kilburg-Basnyat *, K. Dunigan-Russell, M. Hodge *, B. Luo *, J. Madenspacher*, S. Thomas * ...

author keywords: asthma; IL-17A; SR-BI receptor; neutrophilia; adrenal insufficiency
MeSH headings : Adrenal Insufficiency / complications; Adrenal Insufficiency / immunology; Animals; Asthma / immunology; Asthma / metabolism; Asthma / parasitology; Asthma / pathology; CD36 Antigens / deficiency; CD36 Antigens / metabolism; Hypersensitivity / complications; Inflammation / pathology; Interleukin-17 / metabolism; Lung / parasitology; Lung / pathology; Male; Mice, Inbred C57BL; Neutrophils / immunology; Neutrophils / pathology; Ovalbumin / immunology; Pyroglyphidae / physiology; Th17 Cells / immunology
TL;DR: Data indicate that SR-BI dampens pulmonary neutrophilic inflammation and IL-17A production in allergic asthma at least in part by maintaining adrenal function. (via Semantic Scholar)
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Source: Web Of Science
Added: June 28, 2021

2021 journal article

Sex Differences in Pulmonary Eicosanoids and Specialized Pro-Resolving Mediators in Response to Ozone Exposure

TOXICOLOGICAL SCIENCES, 183(1), 170–183.

By: M. Yaeger *, S. Reece *, B. Kilburg-Basnyat *, M. Hodge*, A. Pal *, K. Dunigan-Russell, B. Luo *, D. You n ...

author keywords: air pollution; lipids; lung; inflammation; sex differences
MeSH headings : Animals; Eicosanoids; Female; Lung; Male; Mice; Mice, Inbred C57BL; Ozone / toxicity; Sex Characteristics
TL;DR: Data indicate that O3 drives an increased pulmonary inflammatory and bioactive lipid mediator response in females, and ovariectomy increases susceptibility to O3-induced pulmonary inflammation and injury, as well as decreases pulmonary DHA concentrations. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021

2020 journal article

Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort

PEDIATRIC OBESITY, 16(7).

By: R. Maguire n, J. House n , D. Lloyd n, H. Skinner n, T. Allen *, A. Raffi n, D. Skaar n , S. Park n ...

Contributors: R. Maguire n, J. House n , D. Lloyd n, H. Skinner n, T. Allen *, A. Raffi n, D. Skaar n , S. Park n ...

author keywords: cytokines; maternal obesity; childhood obesity
MeSH headings : Black or African American; Body Mass Index; Child; Child, Preschool; Cohort Studies; Cytokines / blood; Female; Humans; Obesity, Maternal / epidemiology; Pediatric Obesity / epidemiology; Pregnancy; White People
TL;DR: Although maternal systemic inflammation is hypothesized to link maternal pre‐pregnancy obesity to offspring metabolic dysfunction, patient empirical data are limited. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 19, 2021

2008 journal article

Modulation of pulmonary inflammatory responses and antimicrobial defenses in mice exposed to diesel exhaust

TOXICOLOGY AND APPLIED PHARMACOLOGY, 229(3), 310–319.

By: K. Gowdy n, Q. Krantz*, M. Daniels *, W. Linak*, I. Jaspers * & M. Gilmour *

author keywords: diesel exhaust; inflammation; lung; surfactant proteins; clara cell; mice
MeSH headings : Air Pollutants / toxicity; Animals; Cytokines / drug effects; Cytokines / metabolism; Female; Intercellular Adhesion Molecule-1 / drug effects; Intercellular Adhesion Molecule-1 / metabolism; Lung / drug effects; Lung / pathology; Mice; Mice, Inbred BALB C; Neutrophils / drug effects; Neutrophils / metabolism; Occupational Exposure / adverse effects; Pneumonia / chemically induced; Pulmonary Surfactant-Associated Protein A / drug effects; Pulmonary Surfactant-Associated Protein A / metabolism; Pulmonary Surfactant-Associated Protein D / drug effects; Pulmonary Surfactant-Associated Protein D / metabolism; Respiratory Tract Infections / etiology; Time Factors; Up-Regulation / drug effects; Uteroglobin / drug effects; Uteroglobin / metabolism; Vehicle Emissions / toxicity
TL;DR: Exposure to moderate and high occupational levels of DE caused an increase in lung injury and inflammation, and a decrease in host defense molecules, which could result in increased susceptibility to respiratory pathogens. (via Semantic Scholar)
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11. Sustainable Cities and Communities (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Diesel exhaust enhanced susceptibility to influenza infection is associated with decreased surfactant protein expression

INHALATION TOXICOLOGY, 19(14), 1121–1133.

By: J. Ciencewicki*, K. Gowdy n, Q. Krantz*, W. Linak *, L. Brighton*, M. Gilmour  n, I. Jaspers

MeSH headings : Animals; Female; Gene Expression Regulation / physiology; Genetic Predisposition to Disease; Humans; Influenza, Human / etiology; Influenza, Human / genetics; Influenza, Human / metabolism; Mice; Mice, Inbred BALB C; Pulmonary Surfactant-Associated Proteins / biosynthesis; Pulmonary Surfactant-Associated Proteins / genetics; Pulmonary Surfactant-Associated Proteins / physiology; Pulmonary Surfactants / metabolism; Vehicle Emissions / toxicity
TL;DR: Exposure to DE enhances the susceptibility to respiratory viral infections by reducing the expression and production of antimicrobial surfactant proteins, which are components of the interferon-independent antiviral defenses. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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