Kymberly Mae Gowdy

Works (5)

Updated: August 5th, 2023 09:50

2021 article

Scavenger Receptor BI Attenuates IL-17A–Dependent Neutrophilic Inflammation in Asthma

Reece, S. W., Varikuti, S., Kilburg-Basnyat, B., Dunigan-Russell, K., Hodge, M. X., Luo, B., … Gowdy, K. M. (2021, March 1). American Journal of Respiratory Cell and Molecular Biology.

By: S. Reece *, S. Varikuti*, B. Kilburg-Basnyat *, K. Dunigan-Russell *, M. Hodge *, B. Luo *, J. Madenspacher*, S. Thomas * ...

author keywords: asthma; IL-17A; SR-BI receptor; neutrophilia; adrenal insufficiency
MeSH headings : Adrenal Insufficiency / complications; Adrenal Insufficiency / immunology; Animals; Asthma / immunology; Asthma / metabolism; Asthma / parasitology; Asthma / pathology; CD36 Antigens / deficiency; CD36 Antigens / metabolism; Hypersensitivity / complications; Inflammation / pathology; Interleukin-17 / metabolism; Lung / parasitology; Lung / pathology; Male; Mice, Inbred C57BL; Neutrophils / immunology; Neutrophils / pathology; Ovalbumin / immunology; Pyroglyphidae / physiology; Th17 Cells / immunology
topics (OpenAlex): Asthma and respiratory diseases; Receptor Mechanisms and Signaling; Allergic Rhinitis and Sensitization
TL;DR: Data indicate that SR-BI dampens pulmonary neutrophilic inflammation and IL-17A production in allergic asthma at least in part by maintaining adrenal function. (via Semantic Scholar)
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Source: Web Of Science
Added: June 28, 2021

2021 article

Sex Differences in Pulmonary Eicosanoids and Specialized Pro-Resolving Mediators in Response to Ozone Exposure

Yaeger, M. J., Reece, S. W., Kilburg-Basnyat, B., Hodge, M. X., Pal, A., Dunigan-Russell, K., … Gowdy, K. M. (2021, June 23). Toxicological Sciences, Vol. 183, pp. 170–183.

By: M. Yaeger *, S. Reece *, B. Kilburg-Basnyat *, M. Hodge*, A. Pal *, K. Dunigan-Russell *, B. Luo *, D. You n ...

author keywords: air pollution; lipids; lung; inflammation; sex differences
MeSH headings : Animals; Eicosanoids; Female; Lung; Male; Mice; Mice, Inbred C57BL; Ozone / toxicity; Sex Characteristics
topics (OpenAlex): Eicosanoids and Hypertension Pharmacology; Fatty Acid Research and Health; Sulfur Compounds in Biology
TL;DR: Data indicate that O3 drives an increased pulmonary inflammatory and bioactive lipid mediator response in females, and ovariectomy increases susceptibility to O3-induced pulmonary inflammation and injury, as well as decreases pulmonary DHA concentrations. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021

2020 article

Associations between maternal obesity, gestational cytokine levels and child obesity in the NEST cohort

Maguire, R. L., House, J. S., Lloyd, D. T., Skinner, H. G., Allen, T. K., Raffi, A. M., … Hoyo, C. (2020, December 30). Pediatric Obesity, Vol. 16.

By: R. Maguire n, J. House n , D. Lloyd n, H. Skinner n, T. Allen *, A. Raffi n, D. Skaar n , S. Park n ...

Contributors: R. Maguire n, J. House n , D. Lloyd n, H. Skinner n, T. Allen *, A. Raffi n, D. Skaar n , S. Park n ...

author keywords: cytokines; maternal obesity; childhood obesity
MeSH headings : Black or African American; Body Mass Index; Child; Child, Preschool; Cohort Studies; Cytokines / blood; Female; Humans; Obesity, Maternal / epidemiology; Pediatric Obesity / epidemiology; Pregnancy; White People
topics (OpenAlex): Reproductive System and Pregnancy; Gestational Diabetes Research and Management; Adipokines, Inflammation, and Metabolic Diseases
TL;DR: Although maternal systemic inflammation is hypothesized to link maternal pre‐pregnancy obesity to offspring metabolic dysfunction, patient empirical data are limited. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 19, 2021

2008 article

Modulation of pulmonary inflammatory responses and antimicrobial defenses in mice exposed to diesel exhaust

GOWDY, K., KRANTZ, Q., DANIELS, M., LINAK, W., JASPERS, I., & GILMOUR, M. (2008, February 20). Toxicology and Applied Pharmacology.

By: K. Gowdy n, Q. Krantz*, M. Daniels *, W. Linak*, I. Jaspers * & M. Gilmour*

author keywords: diesel exhaust; inflammation; lung; surfactant proteins; clara cell; mice
MeSH headings : Air Pollutants / toxicity; Animals; Cytokines / drug effects; Cytokines / metabolism; Female; Intercellular Adhesion Molecule-1 / drug effects; Intercellular Adhesion Molecule-1 / metabolism; Lung / drug effects; Lung / pathology; Mice; Mice, Inbred BALB C; Neutrophils / drug effects; Neutrophils / metabolism; Occupational Exposure / adverse effects; Pneumonia / chemically induced; Pulmonary Surfactant-Associated Protein A / drug effects; Pulmonary Surfactant-Associated Protein A / metabolism; Pulmonary Surfactant-Associated Protein D / drug effects; Pulmonary Surfactant-Associated Protein D / metabolism; Respiratory Tract Infections / etiology; Time Factors; Up-Regulation / drug effects; Uteroglobin / drug effects; Uteroglobin / metabolism; Vehicle Emissions / toxicity
topics (OpenAlex): Air Quality and Health Impacts; Energy and Environment Impacts; Noise Effects and Management
TL;DR: Exposure to moderate and high occupational levels of DE caused an increase in lung injury and inflammation, and a decrease in host defense molecules, which could result in increased susceptibility to respiratory pathogens. (via Semantic Scholar)
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11. Sustainable Cities and Communities (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 article

Diesel Exhaust Enhanced Susceptibility to Influenza Infection is Associated with Decreased Surfactant Protein Expression

Ciencewicki, J., Gowdy, K., Krantz, Q. T., Linak, W. P., Brighton, L., Gilmour, M. I., & Jaspers, I. (2007, January 1). Inhalation Toxicology.

By: J. Ciencewicki*, K. Gowdy n, Q. Krantz*, W. Linak *, L. Brighton*, M. Gilmour n, I. Jaspers *

MeSH headings : Animals; Female; Gene Expression Regulation / physiology; Genetic Predisposition to Disease; Humans; Influenza, Human / etiology; Influenza, Human / genetics; Influenza, Human / metabolism; Mice; Mice, Inbred BALB C; Pulmonary Surfactant-Associated Proteins / biosynthesis; Pulmonary Surfactant-Associated Proteins / genetics; Pulmonary Surfactant-Associated Proteins / physiology; Pulmonary Surfactants / metabolism; Vehicle Emissions / toxicity
topics (OpenAlex): Air Quality and Health Impacts; Energy and Environment Impacts; Climate Change and Health Impacts
TL;DR: Exposure to DE enhances the susceptibility to respiratory viral infections by reducing the expression and production of antimicrobial surfactant proteins, which are components of the interferon-independent antiviral defenses. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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