@article{gould_grady_tolbert_2024, title={pH-independent effects of acid suppressants in dogs and cats: a One Health perspective and case for further investigation}, volume={85}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.24.07.0194}, abstractNote={Our understanding of the use of acid-suppressant drugs (ASDs) in companion animals is largely centered around the treatment of acid-related disorders including gastroesophageal reflux and gastrointestinal ulceration. The companion article by Grady et al, JAVMA, October 2024, summarizes our current knowledge of the efficacy of and indications for ASDs for the treatment of acid-related disorders. Far less is understood about both the benefits of and potential for adverse effects of ASDs outside of the parietal cell including those directed toward inflammation and immunomodulation, tumorigenesis, fibrosis, and oxidative stress. In this Currents in One Health article, we summarize the pH-independent properties of ASDs as demonstrated in studies conducted largely in humans and rodents. The objective of this review is to highlight and increase awareness of the pH-independent effects of ASDs to elucidate the need for further veterinary research in this area.}, number={10}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Gould, Emily N. and Grady, Kylie and Tolbert, M. Katherine}, year={2024}, month={Oct} }
 @article{grady_ernst_secoura_price_birkenheuer_vaden_lidbury_gould_steiner_tolbert_2023, title={Gastric <scp>pH</scp> and serum gastrin concentration in age‐matched healthy dogs and dogs with chronic kidney disease}, volume={37}, ISSN={0891-6640 1939-1676}, url={http://dx.doi.org/10.1111/jvim.16907}, DOI={10.1111/jvim.16907}, abstractNote={AbstractBackgroundGastric hyperacidity and hypergastrinemia are purported to cause gastric ulceration in dogs with chronic kidney disease (CKD); however, no published studies have evaluated gastric pH with serum gastrin concentrations in dogs with CKD.HypothesisTo compare mean intragastric pH, mean percent pH distribution, and serum gastrin concentrations in dogs with CKD to age‐matched, healthy dogs. We hypothesized there would be no difference in mean gastric pH or serum gastrin between groups.AnimalsThirteen dogs with CKD; 10 aged‐matched healthy dogs.MethodsProspective, case‐control study. Serum chemistry, complete blood count, urinalysis, and serum gastrin concentrations were evaluated in all dogs before radiographic‐assisted gastric placement of a pH capsule. Forty‐eight‐hour continuous gastric pH monitoring was performed in all dogs. Serum gastrin concentration, mean pH, and mean percentage time that gastric pH was strongly acidic (pH <1 and pH <2) were compared between groups using a repeated measures mixed‐model ANOVA.ResultsNo significant differences were observed between groups for any pH measurements, including mean ± SD gastric pH (CKD, 2.37 ± 0.87; healthy, 2.39 ± 0.99; P > .05). Serum gastrin concentrations were not significantly different between groups (median [range]: CKD, 10.5 ng/dL [<10‐17.1]; healthy, 10.9 ng/dL [<10‐15]; P > .05).Conclusions and Clinical ImportanceOur client‐owned dogs with CKD did not have lower gastric pH or higher serum gastrin concentrations compared to healthy dogs. Our results suggest that prophylactic gastric acid suppression in dogs with CKD is not warranted unless other clinical indications for use are present.}, number={6}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Grady, Kylie and Ernst, Eli and Secoura, Patricia L. and Price, Josh and Birkenheuer, Adam and Vaden, Shelly L. and Lidbury, Jonathan and Gould, Emily and Steiner, Joerg M. and Tolbert, M. Katherine}, year={2023}, month={Oct}, pages={2119–2124} }
 @article{cameron_grady_kent_sousa_2023, title={Mild to moderate increases in activity are associated with increased seizure incidence in dogs with idiopathic epilepsy receiving anti-epileptic drugs}, ISSN={["1748-5827"]}, DOI={10.1111/jsap.13655}, abstractNote={ObjectiveEpilepsy is a chronic disorder, and approximately 25% to 30% of dogs with epilepsy are refractory to anti‐epileptic drugs. As increased activity has been shown to reduce seizure frequency in people with epilepsy, the goal of this study was to evaluate the relationship between deviation from baseline activity and seizure incidence in dogs with epilepsy.Materials and MethodsActivity and seizure data were obtained using a canine activity monitoring device and owner observed seizure logs in 53 dogs with idiopathic epilepsy receiving anti‐epileptic drugs. Each dog's activity was individually measured, and 14‐day baseline averages were calculated. Logistic regression was performed to evaluate how an observed increase in activity, ranging from 0% to 50%, above baseline activity, affects the incidence of a seizure in the following 24 hours.ResultsA total of 8540 activity days and 365 seizure days were used in the final analysis with an average of 11 seizures per dog (range 0 to 30 seizures). Seizure incidence was significantly more likely when activity was 10%, 20%, or 30% above baseline activity in the 24 hours before the day of a documented seizure [95% confidence interval (1.02 to 1.60), P=0.033; 95% confidence interval (1.08 to 1.80), P=0.010; 95% confidence interval (1.13 to 2.07), P=0.005, respectively]. However, when activity levels were 40% and 50% above baseline, the effect diminished (95% confidence interval (0.74 to 1.70), P=0.532; or 95% confidence interval (0.56 to 1.66), P=0.988, respectively).Clinical SignificanceDifferently than in humans, this study demonstrated that a mild to moderate increase in activity resulted in a higher seizure incidence within 24 hours in dogs with epilepsy.}, journal={JOURNAL OF SMALL ANIMAL PRACTICE}, author={Cameron, S. and Grady, K. M. and Kent, S. P. and Sousa, M. M.}, year={2023}, month={Aug} }