Kristen M Messenger

Works (62)

Updated: July 9th, 2024 05:02

2024 journal article

Pharmacokinetics of a continuous intravenous infusion of hydromorphone in healthy dogs

FRONTIERS IN VETERINARY SCIENCE, 11.

By: C. Wimbish n, A. Lynch n , H. Knych *, Y. Ueda n  & K. Messenger n

author keywords: constant rate infusion; hydromorphone; dog; pharmacokinetics; pain; opioid
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 8, 2024

2024 article

Pharmacokinetics of intranasal and intramuscular flunixin in healthy grower pigs

Wiloch, E. E., Enomoto, H., Smith, L., Baynes, R. E., & Messenger, K. M. (2024, January 11). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 1.

By: E. Wiloch n, H. Enomoto n, L. Smith n, R. Baynes n  & K. Messenger n

author keywords: analgesia; flunixin; intranasal; pharmacokinetics; swine
TL;DR: Intranasal flunixin has similar, although variable, pharmacokinetic parameters to the intramuscular route, making it a viable route of administration for use in grower swine, according to this study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 16, 2024

2024 article

Pharmacokinetics of subcutaneous ketamine administration via the Omnipod® system in dogs

Colon, C., Early, P., Munana, K., Olby, N., Mariani, C., Mancini, S., … Messenger, K. (2024, March 27). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 3.

By: C. Colon  n, P. Early n, K. Munana n , N. Olby n , C. Mariani n , S. Mancini n, G. Fefer n, Z. Li * ...

author keywords: analgesia; canine; ketamine; novel; veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2024 journal article

Single- and multiple-dose pharmacokinetics of sotalol hydrochloride in healthy cats

JOURNAL OF VETERINARY CARDIOLOGY, 51, 86–96.

By: S. Salmon*, A. Coleman *, C. Lynn *, J. Sanders * & K. Messenger n

author keywords: Antiarrhythmic; Potassium-channel blocker; Beta-adrenergic block-er; Feline; Tachyarrhythmia
TL;DR: Oral sotalol administration resulted in plasma concentrations reportedly efficacious in other species, with good to excellent oral bioavailability, and urinary excretion appears to be a major route of elimination in healthy cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 29, 2024

2024 journal article

Systemic absorption of triamcinolone acetonide is increased from intrasynovial versus extrasynovial sites and induces hyperglycemia, hyperinsulinemia, and suppression of the hypothalamic-pituitary-adrenal axis

FRONTIERS IN VETERINARY SCIENCE, 11.

By: K. Hallowell n, K. Dembek n, C. Horne n, H. Knych *, K. Messenger n & L. Schnabel n

author keywords: corticosteroids; triamcinolone; insulin; cortisol; sacroiliac; horse
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 11, 2024

2023 journal article

Comparative growth dynamics of bacterial and fungal contaminants in bupivacaine liposomal injectable suspension, bupivacaine 0.5%, and propofol

PLOS ONE, 18(2).

By: A. Wallace n, L. Love n, C. Gensler n, M. Jacob n, J. Robertson n  & K. Messenger n

Ed(s): G. Nevárez-Moorillón

MeSH headings : Propofol / pharmacology; Bupivacaine / pharmacology; Prospective Studies; Anesthetics; Escherichia coli; Anesthetics, Local / pharmacology
TL;DR: Bacterial and fungal contaminant growth in artificially inoculated BLIS is organism dependent and extra-label handling of BLIS should only be undertaken with caution and with adherence to strict aseptic technique. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 17, 2023

2023 journal article

Efficacy of inguinal buffered lidocaine and intranasal flunixin meglumine on mitigating physiological and behavioral responses to pain in castrated piglets

FRONTIERS IN PAIN RESEARCH, 4.

By: M. Lopez-Soriano n , V. Merenda  n, S. Anderson n, P. Trindade *, M. Leidig, K. Messenger n, J. Ferreira  n, M. Pairis-Garcia n 

Contributors: M. Lopez-Soriano n , V. Merenda  n, S. Anderson n, P. Trindade *, M. Leidig, K. Messenger n, J. Ferreira  n, M. Pairis-Garcia n 

author keywords: swine; local anesthetic; non-steroidal anti-inflammatory drug (NSAID); cortisol; castration; pain scale; animal welfare; Unesp-Botucatu pig composite acute pain scale (UPAPS)
TL;DR: Intranasal FM was able to effectively reduce the physiological piglet's response immediately post-castration and Inguinal buffered lidocaine had no effect on the either physiological or behavioral response to pain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 3, 2023

2023 article

Pharmacokinetics and efficacy of orally administered acetaminophen (paracetamol) in adult horses with experimentally induced endotoxemia

Mercer, M. A., Davis, J. L., McKenzie, H. C., Messenger, K. M., Schaefer, E., Council-Troche, R. M. A., & Werre, S. R. (2023, February 24). JOURNAL OF VETERINARY INTERNAL MEDICINE.

By: M. Mercer *, J. Davis *, H. McKenzie *, K. Messenger n, E. Schaefer*, R. Council-Troche *, S. Werre *

author keywords: acetaminophen; fever; horse; pyrexia
MeSH headings : Horses; Animals; Acetaminophen / therapeutic use; Acetaminophen / pharmacology; Endotoxemia / drug therapy; Endotoxemia / veterinary; Cross-Over Studies; Chromatography, Liquid / veterinary; Tandem Mass Spectrometry / veterinary; Horse Diseases
TL;DR: Acetaminophen is an option for antipyresis in clinical cases, particularly when administration of traditional NSAIDs is contraindicated, as reported by previous studies in healthy horses. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 13, 2023

2023 journal article

Pharmacokinetics and pharmacodynamics of intramuscular alfaxalone in central bearded dragons (Pogona vitticeps): effect of injection site

VETERINARY ANAESTHESIA AND ANALGESIA, 50(3), 280–288.

By: S. Shippy *, H. Allgood*, K. Messenger n, J. Hernandez *, B. Gatson, M. Bustamante *, A. Alexander *, J. Wellehan Jr, A. Johnson*

author keywords: alfaxalone; bearded dragon; injectable anes-thesia; pharmacokinetics; Pogona vitticeps; sedation
MeSH headings : Animals; Anesthetics / pharmacology; Cross-Over Studies; Injections, Intramuscular / veterinary; Prospective Studies
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 26, 2023

2022 article

Ceftazidime pharmacokinetics in dogs after intravenous injection and delivered with the RxActuator Mini-Infuser infusion pump

Papich, M. G., Madsen, M., Messenger, K., & Enomoto, H. (2022, May 6). JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, Vol. 5.

By: M. Papich n , M. Madsen n, K. Messenger n & H. Enomoto n

author keywords: antimicrobial; canine; cephalosporin; half-life; mean inhibitory concentration
MeSH headings : Animals; Ceftazidime / pharmacokinetics; Dogs; Humans; Infusion Pumps / veterinary; Infusions, Intravenous / veterinary; Injections, Intravenous / veterinary
TL;DR: This study demonstrated the successful application of the RxActuator Mini-Infuser wearable SC constant rate infusion pump for delivering an antimicrobial needed for serious, and sometimes resistant, infections in dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 7, 2022

2022 journal article

Interleukin-1 beta in tendon injury enhances reparative gene and protein expression in mesenchymal stem cells

FRONTIERS IN VETERINARY SCIENCE, 9.

By: D. Koch n, A. Berglund n, K. Messenger n, J. Gilbertie n, I. Ellis n & L. Schnabel n

author keywords: tendon; cytokine; ultrafiltration probe; mesenchymal stem cell; licensing
TL;DR: The defined temporal cytokine microenvironment in a surgically induced model of equine tendon injury and changes in MSC gene and protein expression following in vitro inflammatory licensing with cytokines of similar concentration as identified in vivo support the need to further study the benefit of MSCs administered within the inflamed tendon microenvironment or exogenously licensed with IL-1β in vitro prior to treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 12, 2022

2022 article

Intravenous dexmedetomidine, morphine, or a combination can result in gallbladder wall thickening; with no significant association with plasma histamine concentrations

Bini, G., Cohen, E. B., Chiavaccini, L., Messenger, K. M., & Bailey, K. M. (2022, January 10). VETERINARY RADIOLOGY & ULTRASOUND, Vol. 1.

By: G. Bini *, E. Cohen n , L. Chiavaccini*, K. Messenger n & K. Bailey n

author keywords: canine; dexmedetomidine; gallbladder; histamine; morphine; sonography; ultrasound
MeSH headings : Animals; Dexmedetomidine / pharmacology; Dogs; Gallbladder / diagnostic imaging; Histamine; Morphine / pharmacology; Pilot Projects; Prospective Studies
TL;DR: Gallbladder wall thickening was observed in at least one dog in each group, therefore caution is recommended for gallbladders wall thickness ultrasonographic interpretation in dogs when these drugs have been administered, and the association between histamine plasma concentration and gallbladder thickness was compared with a mixed-effects model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 11, 2022

2022 journal article

Novel subcutaneous cytarabine infusion with the Omnipod system in dogs with meningoencephalomyelitis of unknown etiology

AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(9).

By: S. Mancini n, P. Early n, B. Slater n, N. Olby n , C. Mariani n , K. Munana n , C. Woelfel n, J. Schacher n, L. Zhong  n, K. Messenger n

MeSH headings : Animals; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Cytarabine / therapeutic use; Dogs; Half-Life; Humans; Infusions, Intravenous / veterinary; North Carolina
TL;DR: An SC continuous-rate infusion of cytarabine via the Omnipod system is feasible in dogs and was able to achieve a steady-state concentration of more than 1 μg/mL 4 to 10 hours postinitiation of cyTarabine and a Cmax of 7,510 ng/mL, comparable to values reported previously with IV continuous- rate infusion administration in healthy research Beagles and dogs with meningoencephalomyelitis of unknown etiology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 1, 2022

2022 article

Pharmacokinetic/pharmacodynamic modeling of ketoprofen and flunixin at piglet castration and tail-docking

Nixon, E., Chittenden, J. T., Baynes, R. E., & Messenger, K. M. (2022, July 14). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 7.

By: E. Nixon n , J. Chittenden*, R. Baynes n  & K. Messenger n

author keywords: NSAID; pain; pharmacodynamics; pharmacokinetics; piglet
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal; Clonixin / analogs & derivatives; Dinoprostone; Hydrocortisone; Ketoprofen / pharmacology; Ketoprofen / therapeutic use; Male; Orchiectomy / veterinary; Pain / veterinary; Swine; Tail
TL;DR: Flunixin may be the best NSAID to use in mitigating castration and tail‐docking pain at the current label dose of ketoprofen. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 16, 2022

2022 article

Pharmacokinetics of intravenous, oral transmucosal, and intranasal buprenorphine in healthy male dogs

Enomoto, H., Love, L., Madsen, M., Wallace, A., & Messenger, K. M. (2022, April 21). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS.

By: H. Enomoto n, L. Love n, M. Madsen n, A. Wallace n & K. Messenger n

author keywords: buprenorphine; dog; intranasal; oral transmucosal; pharmacokinetics; Simbadol (TM)
MeSH headings : Administration, Intravenous / veterinary; Administration, Mucosal; Administration, Oral; Analgesics; Animals; Biological Availability; Buprenorphine / pharmacokinetics; Cross-Over Studies; Dogs; Male
TL;DR: Intranasal and OTM routes of administration of concentrated buprenorphine in dogs may allow for the provision of analgesic care at home. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 2, 2022

2022 journal article

Preliminary evaluation of the effects of grapiprant compared with carprofen on acute pain and inflammation following ovariohysterectomy in dogs

AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(7).

By: B. Southern n, S. Long n, D. Barnes n, H. Enomoto n & K. Messenger n

MeSH headings : Acute Pain / drug therapy; Acute Pain / veterinary; Animals; Carbazoles / therapeutic use; Dinoprostone; Dog Diseases / drug therapy; Dogs; Female; Hysterectomy / veterinary; Imidazoles; Inflammation / drug therapy; Inflammation / veterinary; Ovariectomy / veterinary; Pain, Postoperative / drug therapy; Pain, Postoperative / veterinary; Pyridines; Sulfonylurea Compounds
TL;DR: Results of this preliminary study suggested both carprofen and grapiprant may be effective for postoperative pain following OVH in dogs; however, additional studies are warranted to determine grapipant's effectiveness in a larger and more diverse population of dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 27, 2022

2022 journal article

The effect of a ketamine constant rate infusion on cardiovascular variables in sheep anesthetized at the minimum alveolar concentration of sevoflurane that blunts adrenergic responses

AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(3), 205–211.

By: K. Chang *, M. Barletta *, K. Messenger n, D. Sakai *, R. Reed * & J. Quandt *

MeSH headings : Adrenergic Agents / pharmacology; Anesthesia / veterinary; Anesthetics, Inhalation; Animals; Cross-Over Studies; Ketamine; Sevoflurane; Sheep
TL;DR: Ketamine, at the dose administered, did not significantly increase the CI in sheep when determined by partial carbon dioxide rebreathing and there was no significant difference observed between the current and prior study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: March 7, 2022

2021 journal article

Comparative effects of nonsteroidal anti-inflammatory drugs at castration and tail-docking in neonatal piglets

PLOS ONE, 16(11).

By: E. Nixon n , A. Carlson  n, P. Routh n, L. Hernandez n, G. Almond n , R. Baynes n , K. Messenger n

Ed(s): J. Loor

MeSH headings : Animal Husbandry / methods; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal / therapeutic use; Castration / adverse effects; Castration / methods; Clonixin / analogs & derivatives; Clonixin / therapeutic use; Dinoprostone / analysis; Extracellular Fluid / chemistry; Hydrocortisone / blood; Ketoprofen / therapeutic use; Male; Meloxicam / therapeutic use; Pain / drug therapy; Pain / etiology; Pain Management; Swine; Tail
TL;DR: It is demonstrated that management strategies including administration of intramuscular flunixin or ketoprofen to reduce pain associated with processing will likely improve piglet health and welfare in the United States. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
13. Climate Action (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 1, 2021

2021 journal article

Effects of housing environment on oral absorption of acetaminophen in healthy Beagles

AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(1), 80–85.

By: M. Madsen n, H. Enomoto n, K. Messenger n & M. Papich n 

MeSH headings : Acetaminophen; Animals; Cross-Over Studies; Dogs; Gastric Emptying; Housing
TL;DR: It is suggested that in dogs, housing environment (normal environment vs a cage in an unfamiliar environment) did not significantly affect oral absorption and, by extension, gastric emptying of acetaminophen. (via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 7, 2022

2021 journal article

In vivo assessment of a delayed release formulation of larazotide acetate indicated for celiac disease using a porcine model

PLOS ONE, 16(4).

By: H. Enomoto n, J. Yeatts n, L. Carbajal n, B. Krishnan, J. Madan, S. Laumas, A. Blikslager n , K. Messenger n

MeSH headings : Administration, Oral; Animals; Celiac Disease / drug therapy; Drug Liberation; Duodenum / metabolism; Jejunum / metabolism; Oligopeptides / administration & dosage; Oligopeptides / pharmacokinetics; Oligopeptides / therapeutic use; Swine
TL;DR: The data shows that LA is available in detectable concentrations at the site of CeD, with a sensitive liquid chromatography/tandem mass spectrometry method developed to quantify LA concentrations in porcine intestinal fluid samples. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 17, 2021

2021 journal article

Larazotide acetate induces recovery of ischemia-injured porcine jejunum via repair of tight junctions

PLOS ONE, 16(4).

By: Z. Slifer n, L. Hernandez n, T. Pridgen n, A. Carlson  n, K. Messenger n, J. Madan, B. Krishnan, S. Laumas, A. Blikslager n 

MeSH headings : Animals; Disease Models, Animal; Female; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Ischemia / drug therapy; Ischemia / metabolism; Jejunum / blood supply; Jejunum / drug effects; Jejunum / metabolism; Male; Oligopeptides / pharmacology; Oligopeptides / therapeutic use; Permeability / drug effects; Swine; Tight Junctions / drug effects; Tight Junctions / metabolism
TL;DR: It is concluded that LA stimulates repair of ischemic-injured epithelium at the level of the tight junctions, at an optimal dose of 1 μM LA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2021 article

Pharmacokinetic and safety assessment of carboplatin-impregnated calcium sulfate hemihydrate beads in eight rats

Belda, B., Ramos-Vara, J., Messenger, K. M., & Risselada, M. (2021, August 10). VETERINARY SURGERY.

By: B. Belda*, J. Ramos-Vara*, K. Messenger n & M. Risselada*

MeSH headings : Animals; Calcium Sulfate; Carboplatin / toxicity; Male; Platinum; Rats; Rats, Sprague-Dawley
TL;DR: Piled CI-CSH bead implantation is well tolerated in rats with similar elution profile as previously described and minimal Pt was detected systemically suggesting Pt release does not match bead dissolution. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 23, 2021

2021 article

Use of extracorporeal therapy in a dog with heatstroke

Tracy, A., Lynch, A., Messenger, K., Vaden, S., & Vigani, A. (2021, December 14). JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, Vol. 12.

By: A. Tracy n, A. Lynch n , K. Messenger n, S. Vaden n & A. Vigani*

author keywords: cytokines; extracorporeal therapy; heatstroke; hemodialysis; hemoperfusion
MeSH headings : Acute Kidney Injury / veterinary; Animals; Cytokines; Dog Diseases / therapy; Dogs; Heat Stroke / therapy; Heat Stroke / veterinary; Hemoperfusion / veterinary; Male
TL;DR: To the authors' knowledge, this represents the first clinical use of ECT consisting of HD and cytokine adsorption in the management of severe heat-related illness in a dog. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 20, 2021

2020 journal article

Comparative Plasma and Interstitial Fluid Pharmacokinetics of Meloxicam, Flunixin, and Ketoprofen in Neonatal Piglets

FRONTIERS IN VETERINARY SCIENCE, 7.

By: E. Nixon n , G. Almond n , R. Baynes n  & K. Messenger n

author keywords: piglet; pain; welfare; castration; NSAID; pharmacokinetics; interstitial fluid
TL;DR: If drug concentrations in the ISF are more closely related to efficacy than the plasma, then the delay between the Tmax in plasma and ISF may be relevant to the timing of castration in order to provide the greatest analgesic effect. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 30, 2020

2020 journal article

Determination of the minimum alveolar concentration of sevoflurane that blunts adrenergic responses and the effect of a constant rate infusion of ketamine in sheep

RESEARCH IN VETERINARY SCIENCE, 128, 230–235.

By: M. Barletta *, J. Quandt *, R. Reed *, E. Hofmeister * & K. Messenger n

author keywords: Ketamine; MAC-BAR; sevoflurane; sheep; sparing effect
MeSH headings : Adrenergic Agents / administration & dosage; Adrenergic Agents / pharmacology; Anesthesia / veterinary; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Cross-Over Studies; Drug Synergism; Female; Ketamine / administration & dosage; Ketamine / blood; Ketamine / pharmacology; Pulmonary Alveoli / chemistry; Pulmonary Alveoli / drug effects; Sevoflurane / administration & dosage; Sevoflurane / adverse effects; Sevoflurane / pharmacokinetics; Sheep
TL;DR: The MAC-BAR of sevoflurane in sheep was determined and the effect of higher doses of ketamine on inhalational anesthetic agents and their potential adverse effects are warranted. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: February 27, 2020

2020 journal article

Efficacy of a single session in-series hemoperfusion and hemodialysis in the management of carprofen overdose in two dogs

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 30(2), 226–231.

By: M. Fick  n, K. Messenger n & A. Vigani n

author keywords: canine; extracorporeal; nonsteroidal anti-inflammatory; toxicosis; veterinary
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / toxicity; Carbazoles / blood; Carbazoles / toxicity; Charcoal / therapeutic use; Dog Diseases / therapy; Dogs; Hemoperfusion / veterinary; Humans; Poisoning / veterinary; Renal Dialysis / veterinary
TL;DR: It is suggested that the efficacy of hemoperfusion in removing carprofen is short-lived, and extending the treatment beyond the first hour does not produce any therapeutic benefit, and hourly replacement of the charcoal filter should be considered. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 20, 2020

2020 journal article

Pharmacokinetics, sedation and hemodynamic changes following the administration of oral transmucosal detomidine gel in cats

JOURNAL OF FELINE MEDICINE AND SURGERY, 22(12), 1184–1190.

By: P. Smith, M. Tolbert *, E. Gould *, A. Taylor, H. Knych * & K. Messenger n

author keywords: Detomidine gel; alpha-2 agonist; buccal; oral transmucosal; pharmacokinetics
MeSH headings : Administration, Oral; Animals; Blood Pressure / drug effects; Cats / physiology; Conscious Sedation / veterinary; Female; Gels; Heart Rate / drug effects; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / pharmacokinetics; Imidazoles / administration & dosage; Imidazoles / pharmacokinetics; Male; Respiratory Rate / drug effects
TL;DR: The pharmacokinetic profile supports short-term, minimally invasive sedation in this species and is warranted for use in debilitated cats, or prior to general anesthesia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 3, 2020

2020 journal article

Sterility and concentration of liposomal bupivacaine single-use vial when used in a multiple-dose manner

VETERINARY SURGERY, 49(4), 772–777.

By: A. Carlson  n, E. Nixon n , M. Jacob n & K. Messenger n

MeSH headings : Anesthesia, Local / methods; Anesthesia, Local / veterinary; Anesthetics, Local / analysis; Anesthetics, Local / therapeutic use; Bupivacaine / analysis; Bupivacaine / therapeutic use; Drug Contamination; Drug Storage
TL;DR: Single-use liposomal bupivacaine liposome injectable suspension used in a multiple-dose fashion for 5 days yielded no bacterial growth and remained sterile for 5 days when aseptic technique was used. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 27, 2020

2019 journal article

Effect of fentanyl on the induction dose and minimum infusion rate of alfaxalone preventing movement in dogs

VETERINARY ANAESTHESIA AND ANALGESIA, 46(2), 173–181.

By: K. Bennett *, R. Seddighi *, K. Moorhead *, K. Messenger n, S. Cox *, X. Sun *, K. Pasloske, B. Pypendop *, T. Doherty *

author keywords: alfaxalone; anesthesia; dogs; fentanyl; minimum infusion rate
MeSH headings : Anesthesia, Intravenous / veterinary; Anesthetics, Combined; Anesthetics, Intravenous / blood; Anesthetics, Intravenous / pharmacokinetics; Anesthetics, Intravenous / pharmacology; Animals; Cross-Over Studies; Dogs / physiology; Dogs / surgery; Dose-Response Relationship, Drug; Female; Fentanyl / blood; Fentanyl / pharmacokinetics; Fentanyl / pharmacology; Movement / drug effects; Pregnanediones / blood; Pregnanediones / pharmacokinetics; Pregnanediones / pharmacology
TL;DR: Fentanyl, at the doses studied, significantly decreased the alfaxalone induction dose and MIRNM in dogs, and ALF and AHF decreased the MIR NM by 44 ± 8% and 62 ± 5%, respectively. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 18, 2019

2019 journal article

Pharmacokinetics and pharmacodynamics of alfaxalone after a single intramuscular or intravascular injection in mallard ducks (Anas platyrhynchos)

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 42(6), 713–721.

By: T. Kruse *, K. Messenger n, A. Bowman *, T. Aarnes *, T. Wittum * & M. Flint *

author keywords: alfaxalone; Anas platyrhynchos; mallard duck; pharmacodynamics; pharmacokinetic
MeSH headings : Anesthetics / administration & dosage; Anesthetics / blood; Anesthetics / pharmacokinetics; Animals; Area Under Curve; Ducks / blood; Female; Half-Life; Injections, Intramuscular; Injections, Intravenous; Male; Pregnanediones / administration & dosage; Pregnanediones / blood; Pregnanediones / pharmacokinetics
TL;DR: Based on sedation levels and duration, alfaxalone administered at dosages of 10 mg/kg IV or IM in mallard ducks does not induce clinically acceptable anesthesia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: September 16, 2019

2019 journal article

Pharmacokinetics of levofloxacin following oral administration of a generic levofloxacin tablet and intravenous administration to dogs

AMERICAN JOURNAL OF VETERINARY RESEARCH, 80(10), 957–962.

By: M. Madsen n, K. Messenger n & M. Papich n 

MeSH headings : Administration, Intravenous; Administration, Oral; Animals; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid / veterinary; Cross-Over Studies; Dogs / metabolism; Female; Half-Life; Levofloxacin / administration & dosage; Levofloxacin / pharmacokinetics; Male; Tablets
TL;DR: In these dogs, levofloxacin was well absorbed when administered orally, and a dose of approximately 25 mg/kg was sufficient to reach pharmacokinetic-pharmacodynamic targets for treating infections with susceptible Enterobacteriaceae or Pseudomonas aeruginosa. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020

2018 journal article

Effect of fentanyl on the induction dose and minimum infusion rate of alfaxalone preventing movement in female dogs

Veterinary Anaesthesia and Analgesia, 45(6), 885.e2.

By: K. Bennett *, R. Seddighi *, K. Moorhead *, K. Messenger n, S. Cox *, X. Sun *, K. Pasloske, T. Doherty*

Source: Crossref
Added: February 24, 2020

2018 journal article

Pharmacokinetics and pharmacodynamic effects in koi carp (Cyprinus carpio) following immersion in propofol

VETERINARY ANAESTHESIA AND ANALGESIA, 45(4), 529–538.

By: A. Oda n, K. Messenger n, L. Carbajal n, L. Posner n, B. Gardner  n, S. Hammer n, A. Cerreta  n, G. Lewbart n , K. Bailey n

author keywords: fish; immersion; koi carp; pharmacodynamics; pharmacokinetics; propofol
MeSH headings : Anesthesia Recovery Period; Animals; Carps / metabolism; Chromatography, High Pressure Liquid / veterinary; Deep Sedation / methods; Deep Sedation / veterinary; Heart Rate / drug effects; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / blood; Hypnotics and Sedatives / pharmacokinetics; Hypnotics and Sedatives / pharmacology; Immersion; Propofol / administration & dosage; Propofol / blood; Propofol / pharmacokinetics; Propofol / pharmacology
TL;DR: Measurable PPCs were achieved in koi carp anesthetized with propofol by immersion, but recovery time was not. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018

2018 chapter

Recovery of horses from general anesthesia following induction with either propofol or midazolam followed by ketamine

In Journal of the American Veterinary Medical Association (Vol. 253, pp. 101–107).

By: M. Jarrett, K. Bailey*, K. Messenger*, T. Prange*, B. Gaines & L. Posner*

MeSH headings : Anesthesia Recovery Period; Anesthesia, General / veterinary; Anesthetics, Intravenous / administration & dosage; Anesthetics, Intravenous / pharmacokinetics; Animals; Female; Horses / blood; Ketamine / administration & dosage; Ketamine / pharmacokinetics; Male; Midazolam / administration & dosage; Midazolam / pharmacokinetics; Propofol / administration & dosage; Propofol / pharmacokinetics; Prospective Studies; Random Allocation; Treatment Outcome
TL;DR: It is suggested that for horses undergoing short periods of general anesthesia, recovery quality may be better following induction with propofol and ketamine, compared with midazolam and ketamines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

The pharmacokinetics and analgesic effects of extended-release buprenorphine administered subcutaneously in healthy dogs

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 41(4), 502–512.

By: M. Barletta *, S. Ostenkamp n, A. Taylor  n, J. Quandt *, B. Lascelles  n & K. Messenger n

author keywords: buprenorphine; dog; extended-release; pharmacodynamics; pharmacokinetics
MeSH headings : Analgesia / methods; Analgesia / veterinary; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Analgesics, Opioid / pharmacology; Animals; Buprenorphine / administration & dosage; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Buprenorphine / pharmacology; Delayed-Action Preparations; Dogs; Female; Injections, Subcutaneous / veterinary; Male
TL;DR: Results showed that ER-buprenorphine administered at a dose of 0.2 mg/kg resulted in prolonged and sustained plasma concentrations and antinociceptive effects up to 72 hr after drug administration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2018 journal article

The pharmacokinetics of cytarabine administered subcutaneously, combined with prednisone, in dogs with meningoencephalomyelitis of unknown etiology

Journal of Veterinary Pharmacology & Therapeutics, 41(5), 638–643.

By: B. Pastina n, P. Early n, R. Bergman*, J. Nettifee n , A. Maller*, K. Bray *, R. Waldron*, A. Castel * ...

Contributors: B. Pastina n, P. Early n, R. Bergman*, J. Nettifee n , A. Maller*, K. Bray *, R. Waldron*, A. Castel * ...

author keywords: canine; cytarabine; MUE; Pharmacokinetics; sparse sampling; subcutaneous; canine; cytarabine; MUE; pharmacokinetics; sparse sampling; subcutaneous
MeSH headings : Animals; Antimetabolites, Antineoplastic / administration & dosage; Antimetabolites, Antineoplastic / blood; Antimetabolites, Antineoplastic / pharmacokinetics; Antimetabolites, Antineoplastic / therapeutic use; Cytarabine / administration & dosage; Cytarabine / blood; Cytarabine / pharmacokinetics; Cytarabine / therapeutic use; Dog Diseases / drug therapy; Dogs; Drug Combinations; Encephalomyelitis / drug therapy; Encephalomyelitis / veterinary; Female; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / blood; Immunosuppressive Agents / pharmacokinetics; Immunosuppressive Agents / therapeutic use; Injections, Subcutaneous; Male; Meningoencephalitis / drug therapy; Meningoencephalitis / veterinary; Prednisone / administration & dosage; Prednisone / blood; Prednisone / pharmacokinetics; Prednisone / therapeutic use
TL;DR: The pharmacokinetics of CA in dogs with MUE after a single 50 mg/m2 SC injection in dogs was similar to what has been previously reported in healthy beagles; there was moderate variability in the population estimates in this clinical population of dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 19, 2018

2017 journal article

Determination of MACBAR of sevoflurane and evaluation of the effects of a ketamine constant rate infusion on sevoflurane MACBAR in sheep

Veterinary Anaesthesia and Analgesia, 44(1), 195.e3.

By: M. Barletta *, K. Messenger n, E. Hofmeister * & J. Quandt *

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 24, 2020

2017 journal article

Evaluation of cardiovascular variables in sheep anesthetized with sevoflurane in combination with ketamine CRI

Veterinary Anaesthesia and Analgesia, 44(5), 1262.e11–1262.e12.

By: M. Barletta *, K. Messenger n, M. Smith *, M. Thoresen *, J. Peroni * & J. Quandt *

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Crossref
Added: February 24, 2020

2017 journal article

Evaluation of serum cytokines in cats with and without degenerative joint disease and associated pain

Veterinary Immunology and Immunopathology, 183, 49–59.

By: M. Gruen n , K. Messenger n, A. Thomson  n, E. Griffith n, L. Aldrich  n, S. Vaden n, B. Lascelles  n

author keywords: Biomarker; Immunoassay; Multiplex; Arthritis
MeSH headings : Animals; Cat Diseases / blood; Cat Diseases / physiopathology; Cats; Cytokines / blood; Female; Male; Osteoarthritis / blood; Osteoarthritis / diagnostic imaging; Osteoarthritis / physiopathology; Osteoarthritis / veterinary; Pain / veterinary; Radiography / veterinary
TL;DR: Evaluating the concentration of cytokines and chemokines in serum samples obtained from cats with and without degenerative joint disease and associated pain showed that cats with higher radiographic degenerative joints disease scores have higher serum concentrations of IL-4 and IL-8, while Cats with higher orthopedic exam pain scores haveHigher concentrations ofIL-8. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: July 20, 2019

2017 journal article

Oral transmucosal detomidine gel in New Zealand white rabbits (Oryctolagus cuniculus)

Journal of the American Association for Laboratory Animal Science, 56(4), 436–442.

By: M. Williams , C. Long, J. Durrant, G. McKeon, H. Shive, E. Griffith, K. Messenger, R. Fish

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Pharmacokinetic comparison of two buprenorphine formulations after buccal administration in healthy male cats

JOURNAL OF FELINE MEDICINE AND SURGERY, 20(4), 312–318.

By: B. Gulledge*, K. Messenger n, K. Cornell*, H. Lindell * & C. Schmiedt *

MeSH headings : Administration, Buccal; Analgesics, Opioid / administration & dosage; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Buprenorphine / administration & dosage; Buprenorphine / pharmacokinetics; Cats; Cross-Over Studies; Half-Life; Male; Pain / drug therapy; Pain / veterinary; Pain Measurement / veterinary; Random Allocation
TL;DR: A buprenorphine solution prepared from sublingual tablets is absorbed after buccal administration in healthy cats and the extent of absorption is significantly less than that of the commercially available formulation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Pharmacokinetics and pharmacodynamics of an extended-release buprenorphine formulation in dogs

Veterinary Anaesthesia and Analgesia, 44(1), 195.e6.

By: S. Ostenkamp n, M. Barletta*, J. Quandt *, D. Lascelles n  & K. Messenger n

Source: Crossref
Added: January 25, 2020

2017 journal article

Pharmacokinetics, sedation, and hemodynamic changes following administration of oral transmucosal detomidine gel in cats

Veterinary Anaesthesia and Analgesia, 44(1), 195.e5–195.e6.

By: P. Smith  n, K. Messenger n, E. Gould *, H. Knych * & M. Tolbert *

Source: Crossref
Added: February 24, 2020

2017 journal article

Plasma propofol concentrations and pharmacodynamic effects in koi carp ( Cyprinus carpio ) following exposure via immersion

Veterinary Anaesthesia and Analgesia, 44(5), 1262.e4–1262.e5.

By: A. Oda n, K. Messenger n, L. Carbajal n, B. Gardner  n, S. Hammer n, A. Cerreta  n, G. Lewbart n , L. Posner n, K. Bailey  n

Sources: Crossref, NC State University Libraries
Added: January 25, 2020

2016 journal article

A comparison of serum and plasma cytokine values using a multiplexed assay in cats

Veterinary Immunology and Immunopathology, 182, 69–73.

By: M. Gruen n , K. Messenger n, A. Thomson n, E. Griffith n, H. Paradise  n, S. Vaden n, B. Lascelles  n

author keywords: Biomarker; Immunoassay; Feline
MeSH headings : Animals; Biomarkers / blood; Blood Chemical Analysis / methods; Cats / blood; Cats / immunology; Cytokines / blood; Immunoassay / methods; Plasma / immunology
TL;DR: While serum and plasma agreement was generally good, detection was improved using serum samples, and alterations of cytokine concentrations have been associated with joint deterioration and pain in humans, similar changes have not been investigated in cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Assessment of in vitro release of carboplatin from six carrier media

AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(12), 1381–1386.

By: M. Risselada*, D. Marcellin-Little*, K. Messenger*, E. Griffith*, G. Davidson* & M. Papich* 

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Carboplatin / administration & dosage; Delayed-Action Preparations / administration & dosage; Drug Carriers / administration & dosage; Gelatin; Gels; Hemostatics; Microspheres; Neoplasms / drug therapy; Neoplasms / veterinary; Polymers
TL;DR: The poloxamer copolymer gel and hemostatic gelatin sponge released carboplatin rapidly in vitro, whereas calcium sulfate beads did not. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Cytokine and chemokine profiles of aqueous humor and serum in horses with uveitis measured using multiplex bead immunoassay analysis

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 182, 43–51.

By: E. Curto n, K. Messenger n, J. Salmon n & B. Gilger n 

author keywords: Uveitis; Multiplex; Horse; Cytokine; Chemokine; Leptospirosis
MeSH headings : Animals; Aqueous Humor / immunology; Biomarkers / blood; Biomarkers / metabolism; Chemokines / blood; Chemokines / metabolism; Cytokines / blood; Cytokines / metabolism; Horse Diseases / blood; Horse Diseases / diagnosis; Horse Diseases / immunology; Horses; Immunoassay; Inflammation Mediators / blood; Inflammation Mediators / metabolism; Leptospirosis / blood; Leptospirosis / immunology; Leptospirosis / veterinary; Uveitis / blood; Uveitis / immunology; Uveitis / veterinary
TL;DR: The anti-inflammatory cytokine IL-10 and the pro- inflammatory cytokine IP-10 appear to play an important role in ERU. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Pharmacokinetics of detomidine following intravenous or oral-transmucosal administration and sedative effects of the oral-transmucosal treatment in dogs

AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(4), 413–420.

By: K. Messenger*, M. Hopfensperger, H. Knych & M. Papich* 

MeSH headings : Administration, Mucosal; Administration, Oral; Animals; Biological Availability; Chromatography, Liquid; Dexmedetomidine / administration & dosage; Dexmedetomidine / blood; Dexmedetomidine / pharmacokinetics; Dogs / metabolism; Female; Gels; Half-Life; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / blood; Hypnotics and Sedatives / pharmacokinetics; Imidazoles / administration & dosage; Imidazoles / blood; Imidazoles / pharmacokinetics; Infusions, Intravenous / veterinary; Male; Mass Spectrometry
TL;DR: Detomidine gel administered by the OTM route provided sedation suitable for a short, minimally invasive procedure in healthy dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Plasma and serum concentrations of cytarabine administered via continuous intravenous infusion to dogs with meningoencephalomyelitis of unknown etiology

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 40(4), 411–414.

By: P. Early n, K. Crook, L. Williams *, E. Davis *, K. Munana n , M. Papich n , K. Messenger n

Contributors: P. Early n, K. Crook, L. Williams *, E. Davis *, K. Muñana n , M. Papich n , K. Messenger n

MeSH headings : Animals; Area Under Curve; Cytarabine / administration & dosage; Cytarabine / pharmacokinetics; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Encephalomyelitis / blood; Encephalomyelitis / drug therapy; Encephalomyelitis / veterinary; Infusions, Intravenous / veterinary
TL;DR: The steady-state achieved with cytarabine CRI produces a consistent and prolonged exposure in plasma and serum, which is likely to produce equilibrium between blood and the central nervous system in dogs with a clinical diagnosis of MUE. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Carprofen pharmacokinetics in plasma and in control and inflamed canine tissue fluid using in vivo ultrafiltration

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 39(1), 32–39.

By: K. Messenger n, J. Wofford n & M. Papich n 

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / blood; Anti-Inflammatory Agents, Non-Steroidal / metabolism; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Area Under Curve; Body Fluids / chemistry; Carbazoles / blood; Carbazoles / metabolism; Carbazoles / pharmacokinetics; Carrageenan / toxicity; Dinoprostone / metabolism; Dog Diseases / blood; Dog Diseases / chemically induced; Dog Diseases / metabolism; Dogs; Half-Life; Inflammation / chemically induced; Inflammation / metabolism; Inflammation / veterinary; Ultrafiltration / veterinary
TL;DR: In vivo ultrafiltration is a reliable method to determine unbound carprofen in ISF, and that disposition of unbound drug into tissue is much higher than predicted from un bound drug concentration in plasma, however, concentrations and pharmacokinetic parameter estimates are not significantly different in inflamed vs. un-inflamed tissues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 chapter

Non-Steroidal Anti-Inflammatory Drugs

In Veterinary Anesthesia and Analgesia (pp. 227–243).

By: M. Papich  n & K. Messenger n

Source: Crossref
Added: July 27, 2019

2015 journal article

Oral Transmucosal Detomidine Gel for the Sedation of the Domestic Ferret (Mustela putorius furo)

Journal of Exotic Pet Medicine, 24(4), 446–454.

By: B. Phillips n, C. Harms n  & K. Messenger n

author keywords: ferret; detomidine; transmucosal; sedation; alpha-2-receptor agonist
TL;DR: TM detomidine effectively sedated domestic ferrets for physical examination and venipuncture in a teaching laboratory setting and scored significantly increased throughout the study period. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2014 journal article

Evaluation of the Effect of Orally Administered Acid Suppressants on Intragastric pH in Cats

JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(1), 104–112.

By: S. Parkinson*, K. Tolbert *, K. Messenger n, A. Odunayo *, M. Brand*, G. Davidson n, E. Peters*, A. Reed, M. Papich n 

author keywords: Bravo monitoring; Famotidine; Feline; Omeprazole
MeSH headings : Animals; Antacids / administration & dosage; Antacids / pharmacokinetics; Antacids / pharmacology; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / pharmacology; Area Under Curve; Cats / physiology; Cross-Over Studies; Famotidine / pharmacology; Half-Life; Hydrogen-Ion Concentration; Monitoring, Physiologic / instrumentation; Monitoring, Physiologic / veterinary; Ointments; Omeprazole / administration & dosage; Omeprazole / pharmacokinetics; Omeprazole / pharmacology; Stomach / physiology; Tablets
TL;DR: Fractionated enteric‐coated OT is an effective acid suppressant despite disruption of the enteric coating and both omeprazole formulations provide superior acid suppression in cats compared to famotidine or placebo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Meloxicam pharmacokinetics using nonlinear mixed-effects modeling in ferrets after single subcutaneous administration

Journal of Veterinary Pharmacology and Therapeutics, 37(4), 382–387.

By: S. Chinnadurai n, K. Messenger n, M. Papich n  & C. Harms n 

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / administration & dosage; Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics; Female; Ferrets / blood; Ferrets / metabolism; Half-Life; Injections, Subcutaneous; Male; Meloxicam; Sex Factors; Thiazines / administration & dosage; Thiazines / pharmacokinetics; Thiazoles / administration & dosage; Thiazoles / pharmacokinetics
TL;DR: Sex differences in the pharmacokinetic behavior of meloxicam should be taken into consideration when treating ferrets, as these animals are considered effective in other species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Suspected carprofen toxicosis caused by coprophagia in a dog

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 243(5), 709–711.

By: R. Hutchins n, K. Messenger* & S. Vaden*

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Carbazoles / adverse effects; Coprophagia; Dog Diseases / chemically induced; Dogs; Female
TL;DR: Findings for the dog of this report suggested that carprofen toxicosis can be caused by consumption of feces of another dog receiving the drug. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

The use of oral transmucosal detomidine hydrochloride gel to facilitate handling in dogs

JOURNAL OF VETERINARY BEHAVIOR-CLINICAL APPLICATIONS AND RESEARCH, 8(3), 114–123.

By: M. Hopfensperger n, K. Messenger n, M. Papich n  & B. Sherman n

author keywords: detomidine; alpha-2 agonist; sedation; anxiety; dogs; oral transmucosal
TL;DR: Although further evaluation is warranted for use in client-owned dogs, OTM detomidine gel offers a novel sedative and anxiolytic option to facilitate handling of canine subjects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

The pharmacokinetics of cytarabine in dogs when administered via subcutaneous and continuous intravenous infusion routes

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(4), 408–411.

By: K. Crook n, P. Early n, K. Messenger n, K. Munana n , R. Gallagher  n & M. Papich n 

Contributors: K. Crook n, P. Early n, K. Messenger n, K. Muñana n , R. Gallagher  n & M. Papich n 

MeSH headings : Animals; Antimetabolites, Antineoplastic / administration & dosage; Antimetabolites, Antineoplastic / blood; Antimetabolites, Antineoplastic / pharmacokinetics; Area Under Curve; Cross-Over Studies; Cytarabine / administration & dosage; Cytarabine / blood; Cytarabine / pharmacokinetics; Dogs / blood; Dogs / metabolism; Half-Life; Infusions, Intravenous / veterinary; Injections, Subcutaneous / veterinary
TL;DR: The steady state achieved with the cyTarabine CRI may produce a more prolonged exposure of cytarabine at cytotoxic levels in plasma compared to the concentrations after SC administration, as these are two routes of administration commonly employed in the treatment of meningitis of unknown etiology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

The pharmacokinetics of midazolam after intravenous, intramuscular, and rectal administration in healthy dogs

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(5), 471–477.

By: M. Schwartz n, K. Munana n , J. Nettifee-Osborne n, K. Messenger n & M. Papich n 

Contributors: M. Schwartz n, K. Muñana n , J. Nettifee-Osborne n, K. Messenger n & M. Papich n 

MeSH headings : Administration, Rectal; Animals; Anticonvulsants / administration & dosage; Anticonvulsants / blood; Anticonvulsants / pharmacokinetics; Chromatography, High Pressure Liquid; Dogs; Female; Injections, Intramuscular / veterinary; Injections, Intravenous / veterinary; Male; Midazolam / administration & dosage; Midazolam / blood; Midazolam / pharmacokinetics
TL;DR: It is suggested that IM midazolam might be useful in treating seizures in dogs when venous access is unavailable, but higher doses may be needed to account for intermediate bioavailability. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Distribution of enrofloxacin and its active metabolite, using an in vivo ultrafiltration sampling technique after the injection of enrofloxacin to pigs

Journal of Veterinary Pharmacology and Therapeutics, 35(5), 452–459.

By: K. Messenger n, M. Papich*  & A. Blikslager* 

Contributors: K. Messenger n, M. Papich*  & A. Blikslager* 

MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / blood; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacokinetics; Area Under Curve; Bacteria / drug effects; Ciprofloxacin / blood; Ciprofloxacin / metabolism; Ciprofloxacin / pharmacokinetics; Enrofloxacin; Fluoroquinolones / administration & dosage; Fluoroquinolones / blood; Fluoroquinolones / metabolism; Fluoroquinolones / pharmacokinetics; Half-Life; Injections, Subcutaneous; Microbial Sensitivity Tests; Swine / blood
TL;DR: It is demonstrated that the concentration of biologically active enrofloxacin in tissues exceeds the concentration predicted by the unbound fraction in pig plasma, and is sufficient for the pathogens that cause respiratory infections in pigs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2011 journal article

Intravenous and sublingual buprenorphine in horses: pharmacokinetics and influence of sampling site

Veterinary Anaesthesia and Analgesia.

By: K. Messenger, J. Davis, D. Lafevers, B. Barlow & L. Posner

Source: NC State University Libraries
Added: July 28, 2019

2011 journal article

Pharmacokinetics of intravenous and intramuscular buprenorphine in the horse

Journal of Veterinary Pharmacology and Therapeutics, 35(1), 52–58.

By: J. Davis n, K. Messenger*, D. Lafevers*, B. Barlow n & L. Posner*

MeSH headings : Analgesics, Opioid / administration & dosage; Analgesics, Opioid / blood; Analgesics, Opioid / pharmacokinetics; Animals; Area Under Curve; Buprenorphine / administration & dosage; Buprenorphine / blood; Buprenorphine / pharmacokinetics; Cross-Over Studies; Female; Half-Life; Horses / blood; Horses / metabolism; Injections, Intramuscular; Injections, Intravenous; Male
TL;DR: Buprenorphine has a moderate T(1/2) in the horse and was detected at concentrations expected to be therapeutic in other species after i.v. and i.m. administration of 0.005 mg/kg. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Pharmacokinetics of lidocaine and its active metabolite monoethylglycinexylidide after a single intravenous administration in chickens (Gallus domesticus) anesthetized with isoflurane

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 35(6), 604–607.

By: A. Da Cunha *, K. Messenger*, R. Stout, S. Barker, J. Nevarez, P. Queiroz-Williams, T. Tully

MeSH headings : Anesthesia, Inhalation; Anesthetics, Inhalation / pharmacology; Anesthetics, Local / administration & dosage; Anesthetics, Local / blood; Anesthetics, Local / metabolism; Anesthetics, Local / pharmacokinetics; Animals; Area Under Curve; Chickens / blood; Female; Half-Life; Injections, Intravenous; Isoflurane / pharmacology; Lidocaine / administration & dosage; Lidocaine / analogs & derivatives; Lidocaine / blood; Lidocaine / metabolism; Lidocaine / pharmacokinetics
Source: Web Of Science
Added: August 6, 2018

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