Kazuhito Sai

Works (4)

Updated: July 11th, 2023 21:14
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2023 journal article

Aberrantly activated TAK1 links neuroinflammation and neuronal loss in Alzheimer?s disease mouse models

JOURNAL OF CELL SCIENCE, 136(6).

By: K. Sai n, A. Nakanishi n, K. Scofield n, D. Tokarz n, K. Linder n, T. Cohen *, J. Ninomiya-Tsuji  n

author keywords: Alzheimer?s disease; Cell death; Inflammation; TAK1
MeSH headings : Animals; Mice; Alzheimer Disease / genetics; Calcium; Cytokines / metabolism; Neuroinflammatory Diseases; Signal Transduction / physiology
Sources: Web Of Science, ORCID
Added: May 30, 2023

2021 journal article

TAK1 inhibition elicits mitochondrial ROS to block intracellular bacterial colonization

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(25).

By: W. Lopez-Perez n, K. Sai n, Y. Sakamachi n, C. Parsons n, S. Kathariou n & J. Ninomiya-Tsuji  n

author keywords: TAK1; ROS; mitochondria; intracellular bacteria
MeSH headings : Animals; Bacteria / growth & development; Caspase 3 / metabolism; Colony Count, Microbial; Hydrogen Sulfide / pharmacology; Intracellular Space / microbiology; MAP Kinase Kinase Kinases / antagonists & inhibitors; MAP Kinase Kinase Kinases / metabolism; Mice; Mitochondria / metabolism; Reactive Oxygen Species / metabolism; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Salmonella / drug effects; Salmonella / growth & development; Yersinia / drug effects
Source: Web Of Science
Added: July 12, 2021

2019 journal article

Necroptosis mediators RIPK3 and MLKL suppress intracellular Listeria replication independently of host cell killing

JOURNAL OF CELL BIOLOGY, 218(6), 1994–2005.

By: K. Sai n, C. Parsons n, J. House n , S. Kathariou n & J. Ninomiya-Tsuji  n

MeSH headings : Animals; Female; Humans; Listeria / growth & development; Listeria / immunology; Listeria / metabolism; Listeriosis / metabolism; Listeriosis / microbiology; Listeriosis / pathology; Listeriosis / prevention & control; Mice; Mice, Inbred C57BL; Mice, Knockout; Necroptosis; Protein Kinases / physiology; Receptor-Interacting Protein Serine-Threonine Kinases / genetics; Receptor-Interacting Protein Serine-Threonine Kinases / metabolism; Receptor-Interacting Protein Serine-Threonine Kinases / physiology
Sources: Web Of Science, ORCID
Added: June 24, 2019

2016 journal article

TAK1 regulates hepatic lipid homeostasis through SREBP

ONCOGENE, 35(29), 3829–3838.

By: S. Morioka n, K. Sai n, E. Omori n, Y. Ikeda  n, K. Matsumoto * & J. Ninomiya-Tsuji  n

MeSH headings : Animals; Carcinoma, Hepatocellular / genetics; Carcinoma, Hepatocellular / metabolism; Cell Line; Fatty Liver / genetics; Fatty Liver / metabolism; Female; HEK293 Cells; Hep G2 Cells; Hepatocytes / metabolism; Homeostasis; Humans; Immunoblotting; Lipid Metabolism; Liver / metabolism; Liver Neoplasms / genetics; Liver Neoplasms / metabolism; MAP Kinase Kinase Kinases / genetics; MAP Kinase Kinase Kinases / metabolism; Male; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Protein Binding; RNA Interference; Risk Factors; Sterol Regulatory Element Binding Proteins / genetics; Sterol Regulatory Element Binding Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018