Lyndy Bleu Harden
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Works (14)
Updated: April 3rd, 2024 20:48
2024 journal article
Characteristics of antimicrobial resistance in <i>Escherichia coli</i> isolated from retail meat products in North Carolina
PLOS ONE, 19(1).
TL;DR:
The lack of an association between MDR E. coli in retail meat and antibiotic use claim, including those with no indication of antimicrobial use, suggests that additional research is required to understand the origin of resistance.
(via Semantic Scholar)
journals.plos.org (publisher PDF)
Sources: Web Of Science, NC State University Libraries
Added: February 26, 2024
2024 article
Serovar-level identification of bacterial foodborne pathogens from full-length 16S rRNA gene sequencing
Grinevich, D., Harden, L., Thakur, S., & Callahan, B. (2024, February 6). (M. G. I. Langille, Ed.). MSYSTEMS, Vol. 2.
Ed(s): M. Langille
author keywords: serotyping; food-borne pathogens; Salmonella; Escherichia coli; 16S rRNA; long-read sequencing
TL;DR:
A new computational technology is developed that allows the important foodborne pathogens Escherichia coli and Salmonella enterica to be serotyped (a subspecies level classification) from sequencing of a single-marker gene, and the 16S rRNA gene often used to surveil bacterial communities.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 7, 2024
2023 journal article
Detection of resistance and virulence plasmids in Campylobacter coli and Campylobacter jejuni isolated from North Carolina food animal production, 2018-2019
FOOD MICROBIOLOGY, 116.
author keywords: Antimicrobial resistance; Food -borne pathogen; Horizontal gene transfer; Transposons; Bioinformatics
TL;DR:
This study highlights the extensive distribution and diversity of Campylobacter plasmids in food animal production and their role in the dissemination of biomedically important genes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 2, 2023
2023 article
Draft Genome Sequences of Escherichia coli and Enterococcus faecalis Coisolated from Polymicrobial Extraintestinal Infections of Chickens and Turkeys
Walker, G. K., Harden, L., Suyemoto, M. M., Thakur, S., Jacob, M., & Borst, L. B. (2023, February 21). MICROBIOLOGY RESOURCE ANNOUNCEMENTS, Vol. 2.
TL;DR:
It is reported that draft genome sequences of 18 APEC and 18 E. faecalis strains coisolated from lesions of diseased poultry with colisepticemia are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 20, 2023
2023 article
Draft genome sequences of 12 Escherichia coli co-isolated with Enterococcus spp. from dogs with polybacterial bacteriuria at a veterinary hospital
Walker, G. K., Harden, L., Suyemoto, M. M., Thakur, S., Jacob, M., & Borst, L. B. (2023, August 8). MICROBIOLOGY RESOURCE ANNOUNCEMENTS, Vol. 8.
author keywords: E; coli; UPEC; canine urinary tract infection; polymicrobial infections
TL;DR:
The draft genome sequences of 12 UPEC co-isolated with Enterococcus spp.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023
2022 journal article
Evidence of sheep and abattoir environment as important reservoirs of multidrug-resistant Salmonella and extended-spectrum beta-lactamase Escherichia coli
International Journal of Food Microbiology, 363, 109516.
author keywords: Salmonella; Abattoir; Sheep; Antimicrobial susceptibility; Prevalence
MeSH headings : Abattoirs; Animals; Anti-Bacterial Agents / pharmacology; Cattle; Chickens; Cross-Sectional Studies; Drug Resistance, Multiple, Bacterial; Escherichia coli / genetics; Salmonella / genetics; Sheep; Swine; beta-Lactamases / genetics
TL;DR:
It is reaffirmed that sheep and their abattoir environment act as important reservoirs of AMR ESBL E. coli and MDR Salmonella in the U.S. and further studies are required to determine associated public health risks.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 5, 2022
2022 journal article
Genomics of human and chicken Salmonella isolates in Senegal: Broilers as a source of antimicrobial resistance and potentially invasive nontyphoidal salmonellosis infections
PLOS ONE, 17(3).
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Chickens; Drug Resistance, Bacterial / genetics; Drug Resistance, Multiple, Bacterial / genetics; Gastroenteritis / microbiology; Genomics; Humans; Microbial Sensitivity Tests; Phylogeny; Salmonella; Salmonella Infections / epidemiology; Salmonella Infections / microbiology; Senegal / epidemiology
TL;DR:
A whole-genome sequence analysis of 72 strains of Salmonella isolated from diarrheic human patients and chicken meat sold in multipurpose markets in Dakar, Senegal revealed frequent resistance to fluoroquinolones and the sulfamethoxazole-trimethoprim combination that are among the most used treatments for invasiveSalmonella.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 25, 2022
2022 journal article
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria
Scientific Reports, 12(1).
MeSH headings : Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Drug Resistance, Multiple, Bacterial / genetics; Escherichia coli / genetics; Escherichia coli Infections / drug therapy; Escherichia coli Infections / epidemiology; Escherichia coli Proteins / genetics; Female; Humans; Male; Microbial Sensitivity Tests; Nigeria / epidemiology; Tertiary Care Centers; beta-Lactamases / genetics; beta-Lactamases / metabolism
TL;DR:
The genetic diversity and MDR E. coli with the emergence of ST410 and ST101 clones is concerning because of the potential for rapid dissemination in hospitals and communities- further increasing the problems of antibiotic resistance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: September 28, 2022
2022 journal article
Multidrug resistance and virulence genes carried by mobile genomic elements in Salmonella enterica isolated from live food animals, processed, and retail meat in North Carolina, 2018-2019
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 378.
author keywords: Whole-genome sequencing; Plasmid assembly; Bioinformatics; Pathogen fitness; Food safety
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Cattle; Drug Resistance, Multiple, Bacterial / genetics; Genomics; Humans; Meat; Microbial Sensitivity Tests; North Carolina; Plasmids; Poultry; Salmonella Infections; Salmonella enterica; Swine; Virulence / genetics; Virulence Factors / genetics
TL;DR:
Plasmid-mediated virulence factors also appear to provide a fitness advantage, as the dominant S. enterica serotype Kentucky in chicken retail meat held the greatest diversity of plasmID-mediated colicin virulence genes which are often upregulated by environmental stressors and confer a competitive advantage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 15, 2022
2021 journal article
Colonization with multidrug-resistant Enterobacteriaceae among infants: an observational study in southern Sri Lanka
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL, 10(1).
author keywords: ESBL; CRE; Multidrug-resistant Enterobacteriaceae; Sri Lanka; Intestinal colonization
MeSH headings : Adult; Drug Resistance, Multiple, Bacterial; Enterobacteriaceae / drug effects; Enterobacteriaceae Infections / epidemiology; Female; Hospitals, Teaching; Humans; Infant, Newborn; Male; Pregnancy; Rectum / microbiology; Sri Lanka / epidemiology; Whole Genome Sequencing
TL;DR:
The results suggest that a substantial proportion of infants undergo MDRE intestinal colonization within 6 weeks of birth, potentially due to postnatal rather than intranatal transmission.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021
2021 journal article
Identification of CTX-M type ESBL E. coli from sheep and their abattoir environment using whole-genome sequencing
Pathogens, 10(11), 1480.
author keywords: abattoir environment; antimicrobial resistance; E. coli; ESBL; North Carolina; sheep; whole-genome sequencing
TL;DR:
This is the first comprehensive AMR and WGS report on ESBL E. coli from sheep and abattoir environments in the United States and associated AMR genes, point mutations, and plasmids.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 16, 2021
2021 journal article
Resistome of a carbapenemase-producing novel ST232 Klebsiella michiganensis isolate from urban hospital effluent in South Africa
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 24, 321–324.
author keywords: Klebsiella michiganensis; Genome; Carbapenemase; Hospital effluent; South Africa
MeSH headings : Bacterial Proteins; Drug Resistance, Bacterial / genetics; Hospitals, Urban; Klebsiella / drug effects; Klebsiella / genetics; South Africa; beta-Lactamases
TL;DR:
This study represents the first report of a blaOXA-181 carbapenemase-producing K. michiganensis isolate from hospital effluent in South Africa and presents a potential risk to informal communities that may use contaminated surface water domestically.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 26, 2021
2021 journal article
The effect of vegetation barriers at reducing the transmission of Salmonella and Escherichia coli from animal operations to fresh produce
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 347.
author keywords: Seasonality; Repetitive PCR; Dairy; Poultry; Distance; Wind
MeSH headings : Animals; Cattle; Dairying; Escherichia coli / growth & development; Escherichia coli / isolation & purification; Escherichia coli Infections / transmission; Escherichia coli Infections / veterinary; Farms; Feces / microbiology; Lettuce / microbiology; Solanum lycopersicum / microbiology; Poultry / microbiology; Salmonella / growth & development; Salmonella / isolation & purification; Salmonella Infections, Animal / transmission
TL;DR:
Data analysis suggests that the VB is an effective tool at reducing the transmission of E. coli and Salmonella from animal farms to fresh produce fields, and recommends the need for more effective bioremediation and prevention control measures to use in conjunction with VBs to reduce pathogen transmission.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021
2016 journal article
Efficacy of a single dose of trazodone hydrochloride given to cats prior to veterinary visits to reduce signs of transport- and examination-related anxiety
Journal of the American Veterinary Medical Association, 249(2), 202–207.
MeSH headings : Animal Welfare; Animals; Anti-Anxiety Agents / pharmacology; Anxiety / prevention & control; Behavior, Animal / drug effects; Cats; Cross-Over Studies; Trazodone / pharmacology
TL;DR:
Oral administration of a single dose of trazodone to cats prior to a veterinary visit resulted in fewer signs of transport- and examination-related anxiety than did a placebo and was generally well tolerated by most cats.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
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