@article{jordan_mamo_olivry_liu_bizikova_2024, title={Re-evaluating the prevalence of anti-desmocollin-1 IgA autoantibodies in canine pemphigus foliaceus}, volume={273}, ISSN={["1873-2534"]}, DOI={10.1016/j.vetimm.2024.110773}, abstractNote={Pemphigus foliaceus (PF) is an autoimmune skin disease of dogs characterized by intraepidermal pustules containing neutrophils and dissociated keratinocytes that develop in association with circulating and tissue-bound IgG autoantibodies. A subset of IgG autoantibodies in canine PF target desmocollin-1 (DSC1), a component of intercellular adhesion complexes within the epidermis. Passive transfer of IgG autoantibodies from canine PF sera to mice was previously shown to induce skin disease in the absence of infiltrating neutrophils. In attempts to identify a mechanism responsible for neutrophil recruitment, past studies evaluated the prevalence of IgA autoantibodies in canine PF sera where they were found in <20% of affected dogs. We re-evaluated the prevalence of anti-DSC1 IgA in canine PF due to concerns regarding the sensitivity of previously used methods. We hypothesized that anti-DSC1 IgA are present in most dogs with PF but have been under-detected due to competition with concurrent anti-DSC1 IgG for binding to their mutual antigenic target. Despite removing approximately 80% of IgG from patient sera using affinity chromatography, we did not detect an increase in anti-DSC1 IgA by performing indirect immunofluorescence on canine DSC1-transfected HEK293T cells. Taken together, our results do not support a role for pathogenic IgA in canine PF.}, journal={VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY}, author={Jordan, Tyler J. M. and Mamo, Lisa B. and Olivry, Thierry and Liu, Zhi and Bizikova, Petra}, year={2024}, month={Jul} } @article{berg_jacob_mamo_pluta_lunn_2023, title={Refrigerated multi-dose insulin vials remain sterile through 6 months of use}, volume={8}, ISSN={["1748-5827"]}, url={https://doi.org/10.1111/jsap.13664}, DOI={10.1111/jsap.13664}, abstractNote={ObjectivesTo evaluate sterility in refrigerated multi‐dose insulin vials through 6 months of routine aspiration.}, journal={JOURNAL OF SMALL ANIMAL PRACTICE}, author={Berg, A. S. and Jacob, M. E. and Mamo, L. B. and Pluta, D. H. and Lunn, K. F.}, year={2023}, month={Aug} } @article{herrmann_mamo_holmes_mohammed_murphy_bizikova_2022, title={Long-term effects of ciclosporin and oclacitinib on mediators of tolerance, regulatory T-cells, IL-10 and TGF-beta, in dogs with atopic dermatitis}, ISSN={["1365-3164"]}, DOI={10.1111/vde.13140}, abstractNote={Abstract}, journal={VETERINARY DERMATOLOGY}, author={Herrmann, Ina and Mamo, Lisa B. and Holmes, Jenny and Mohammed, Javid P. and Murphy, K. Marcia and Bizikova, Petra}, year={2022}, month={Dec} } @article{bizikova_linder_mamo_2022, title={Trunk-dominant and classic facial pemphigus foliaceus in dogs - comparison of anti-desmocollin-1 and anti-desmoglein-1 autoantibodies and clinical presentations}, ISSN={["1365-3164"]}, DOI={10.1111/vde.13094}, abstractNote={Abstract}, journal={VETERINARY DERMATOLOGY}, author={Bizikova, Petra and Linder, Keith E. and Mamo, Lisa B.}, year={2022}, month={Jun} } @article{levy_linder_mamo_herrmann_bizikova_2020, title={Cutaneous polyautoimmunity in two unrelated dogs: pemphigus foliaceus and generalized discoid lupus erythematosus}, volume={31}, ISSN={["1365-3164"]}, DOI={10.1111/vde.12851}, abstractNote={BackgroundPolyautoimmunity, the concurrent expression of two or more distinct autoimmune diseases (ADs) in a single individual, is a known phenomenon in humans and has been rarely reported in dogs. To the best of the authors’ knowledge, comorbid pemphigus foliaceus (PF) and generalized discoid lupus erythematosus (GDLE) has not been reported in dogs.}, number={4}, journal={VETERINARY DERMATOLOGY}, author={Levy, Britt J. and Linder, Keith E. and Mamo, Lisa B. and Herrmann, Ina and Bizikova, Petra}, year={2020}, month={Aug}, pages={325-+} } @article{levy_mamo_bizikova_2020, title={Detection of circulating anti-keratinocyte autoantibodies in feline pemphigus foliaceus}, volume={31}, ISSN={["1365-3164"]}, DOI={10.1111/vde.12861}, abstractNote={BackgroundCirculating anti‐keratinocyte immunoglobulin (Ig)G targeting desmosomal proteins have been identified in people and dogs with pemphigus foliaceus (PF). By contrast, detection attempts in PF‐affected cats have been largely unsuccessful.}, number={5}, journal={VETERINARY DERMATOLOGY}, author={Levy, Britt J. and Mamo, Lisa B. and Bizikova, Petra}, year={2020}, month={Oct}, pages={378-+} } @article{high_linder_mamo_levy_herrmann_bizikova_2020, title={Rapid response of hyperkeratotic erythema multiforme to oclacitinib in two dogs}, volume={31}, ISSN={["1365-3164"]}, DOI={10.1111/vde.12852}, abstractNote={BackgroundHyperkeratotic erythema multiforme (HKEM) is a clinically distinct dermatosis and poorly characterized syndrome, comprised of hyperkeratotic plaques with variable symmetry and apoptosis similar to “classic” erosive canine EM. Hyperkeratotic EM has a protracted clinical course and, although treatments with glucocorticoids, azathioprine and/or ciclosporin have been tried, rates of remission are low.}, number={4}, journal={VETERINARY DERMATOLOGY}, author={High, Endya J. and Linder, Keith E. and Mamo, Lisa B. and Levy, Britt J. and Herrmann, Ina and Bizikova, Petra}, year={2020}, month={Aug}, pages={330-+} } @article{bizikova_linder_wofford_mamo_dunston_olivry_2015, title={Canine epidermolysis bullosa acquisita: A retrospective study of 20 cases}, volume={26}, number={6}, journal={Veterinary Dermatology}, author={Bizikova, P. and Linder, K. E. and Wofford, J. A. and Mamo, L. B. and Dunston, S. M. and Olivry, T.}, year={2015}, pages={441-} } @article{bizikova_olivry_mamo_dunston_2014, title={Serum autoantibody profiles of IgA, IgE and IgM in canine pemphigus foliaceus}, volume={25}, ISSN={["1365-3164"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84911375280&partnerID=MN8TOARS}, DOI={10.1111/vde.12143}, abstractNote={BackgroundPemphigus foliaceus (PF) is the most common IgG‐mediated autoimmune skin disease in dogs. Studies of human PF have revealed the presence of other antigen‐specific autoantibody isotypes, thereby uncovering new avenues of investigation of the disease pathomechanism.}, number={5}, journal={VETERINARY DERMATOLOGY}, author={Bizikova, Petra and Olivry, Thierry and Mamo, Lisa B. and Dunston, Stanley M.}, year={2014}, month={Oct}, pages={471–E75} }