@article{hovda_graham_love_2024, title={Ventricular arrhythmias during anesthesia in a juvenile German Shepherd Dog}, volume={262}, ISSN={["1943-569X"]}, DOI={10.2460/javma.23.09.0529}, number={2}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Hovda, Tyne and Graham, Lynelle and Love, Lydia}, year={2024}, month={Feb}, pages={263–265} }
 @article{wallace_love_gensler_jacob_robertson_messenger_2023, title={Comparative growth dynamics of bacterial and fungal contaminants in bupivacaine liposomal injectable suspension, bupivacaine 0.5%, and propofol}, volume={18}, ISSN={["1932-6203"]}, url={https://doi.org/10.1371/journal.pone.0281768}, DOI={10.1371/journal.pone.0281768}, abstractNote={Objective To determine whether bupivacaine liposomal injectable suspension (BLIS) supports microbial growth when artificially inoculated and to evaluate liposomal stability in the face of this extrinsic contamination as evidenced by changes in free bupivacaine concentrations. Study design A randomized, prospective in vitro study in which three vials of each BLIS, bupivacaine 0.5%, and propofol were individually inoculated with known concentrations of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans (n = 36) to quantify bacterial and fungal growth was conducted. Over 120 hours, aliquots from contaminated vials were withdrawn, plated, and incubated to determine microbial concentrations. High-pressure liquid chromatography (HPLC) was used to evaluate free bupivacaine concentrations over time in BLIS. Data were analyzed using a mixed effects model with multiple comparisons. Sample population Twelve vials of each BLIS, bupivacaine 0.5%, and propofol. Results BLIS did not support significant growth of Staphylococcus aureus or Candida albicans at any time. BLIS supported significant growth of Escherichia coli and Pseudomonas aeruginosa beginning at the 24 hour time point. Bupivacaine 0.5% did not support significant growth of any organisms. Propofol supported significant growth of all organisms. Free bupivacaine concentrations changed minimally over time. Conclusion Bacterial and fungal contaminant growth in artificially inoculated BLIS is organism dependent. BLIS supports significant growth of Escherichia coli and Pseudomonas aeruginosa. Extra-label handling of BLIS should only be undertaken with caution and with adherence to strict aseptic technique.}, number={2}, journal={PLOS ONE}, author={Wallace, Amber and Love, Lydia and Gensler, Catherine and Jacob, Megan and Robertson, James and Messenger, Kristen}, editor={Nevárez-Moorillón, Guadalupe VirginiaEditor}, year={2023}, month={Feb} }
 @article{hofmeister_love_2023, title={Patient safety culture is needed in veterinary medicine}, volume={261}, ISSN={["1943-569X"]}, DOI={10.2460/javma.23.07.0370}, abstractNote={Studies in human medicine indicate that between 22,000 and 400,000 people die every year as a direct result of medical errors. In veterinary medicine, 42% of human-caused incidents caused harm to the patient, including 5% resulting in death. In a university veterinary teaching hospital, there were 5.3 errors/1,000 patient visits, and 4 of these resulted in death. Veterinary medicine falls far behind other safety-critical industries in adopting a culture of patient safety. Organizations should respond in a just and effective way when errors occur. Psychological safety for team members to identify and speak up about areas of concern must be created and the results of improvements made based on these concerns shared within the professional group. If veterinary medicine is going to embrace patient safety culture, it needs to be included in the curriculum. Accrediting and licensing bodies need to require the teaching and application of principles of patient safety culture. Faculty must be trained to deliver patient safety-oriented care. Experts in human systems engineering should be brought in to educate veterinarians on how the systems we work in impact patient outcomes. If we are going to fulfill the promise of the Veterinarian's Oath, we must embrace patient safety culture and all the difficult changes it requires of our professional culture.}, number={12}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Hofmeister, Erik H. and Love, Lydia}, year={2023}, month={Dec}, pages={1908–1912} }
 @article{enomoto_love_madsen_wallace_messenger_2022, title={Pharmacokinetics of intravenous, oral transmucosal, and intranasal buprenorphine in healthy male dogs}, ISSN={["1365-2885"]}, DOI={10.1111/jvp.13056}, abstractNote={Abstract Effective management of pain in animals is of critical importance but options are limited for treating acute pain in dogs on an outpatient basis. The objective of this study was to compare the plasma concentrations and pharmacokinetics of a concentrated solution of buprenorphine, 1.8 mg/ml (Simbadol™) administered intravenously, intranasally, and via the oral transmucosal (OTM) route in healthy male dogs. Five healthy castrated adult male Beagle‐cross dogs were included in this randomized blocked crossover study. The dogs received 0.03 mg/kg body weight buprenorphine intravenously, intranasally, or via the OTM route, with a minimum 72‐h washout period between treatments. Blood samples were collected at multiple intervals up to 24 h post administration and buprenorphine plasma concentrations were determined by liquid chromatography tandem mass spectrometry. Non‐compartmental pharmacokinetic analysis revealed that the area under the curve of intravenous, intranasal, and OTM routes were 28.0 (15.1–41.3) h × ng/ml, 16.1 (3.4–28.7) h × ng/ml and 10.8 (8.8–11.8) h × ng/ml, respectively. The bioavailability of intranasal and OTM routes were 57.5 (22.7–93.7)% and 41.1 (25.5–69.4)%, respectively. Intranasal and OTM routes of administration of concentrated buprenorphine in dogs may allow for the provision of analgesic care at home.}, journal={JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS}, author={Enomoto, Hiroko and Love, Lydia and Madsen, Melanie and Wallace, Amber and Messenger, Kristen M.}, year={2022}, month={Apr} }
 @article{love_hedgpeth_robertson_marks_schoenfeld-tacher_2021, title={Assessment of Safety Culture at a Veterinary Teaching Hospital in the United States}, volume={8}, ISSN={["2297-1769"]}, DOI={10.3389/fvets.2021.638764}, abstractNote={This study assessed the fidelity of an existing questionnaire regarding attitudes toward safety culture in an academic veterinary hospital setting and gathered baseline data on these attitudes in a local population. A cross-sectional study design was used to evaluate perceptions held by veterinary teaching hospital employees. An established veterinary safety culture survey was modified and administered as a confidential online survey to faculty, house officers, and professional staff of a veterinary teaching hospital in the United States. Confirmatory and exploratory factor analysis were conducted to compare the adapted survey to the established version. Descriptive statistics were used to characterize baseline safety culture. The adapted survey exhibited factor groupings that were mostly in agreement with, but slightly different from, the original instrument. In general, survey respondents outlined positive attitudes toward the various domains of safety culture, though we identified opportunities for improvement in some areas. An adapted veterinary safety culture survey can be applied to a veterinary teaching hospital in the United States to assess baseline data surrounding the culture of safety and to identify opportunities for focused improvement efforts.}, journal={FRONTIERS IN VETERINARY SCIENCE}, author={Love, Lydia C. and Hedgpeth, Mari-Wells and Robertson, James B. and Marks, Steven L. and Schoenfeld-Tacher, Regina M.}, year={2021}, month={Mar} }
 @article{hovda_love_chiavaccini_2021, title={Risk factors associated with hypoxaemia in horses undergoing general anaesthesia: A retrospective study}, ISSN={["2042-3306"]}, DOI={10.1111/evj.13541}, abstractNote={BACKGROUND
Hypoxaemia is a common concern during equine general anaesthesia. The prevalence and predictors of hypoxaemia in horses undergoing elective anaesthesia in particular are poorly documented.


OBJECTIVES
To determine and compare the prevalence of hypoxaemia (defined as PaO2 ≤ 80 mmHg, on the lowest value recorded) in horses undergoing anaesthesia for exploratory laparotomy and elective procedures, and to identify risk factors in both subpopulations.


STUDY DESIGN
Retrospective cohort study.


METHODS
Data were collected from 774 records of 708 horses undergoing general anaesthesia between April 2017 and August 2020. Potential predictors of hypoxaemia in horses undergoing anaesthesia for exploratory laparotomy or elective procedures were investigated separately by univariable penalised maximum likelihood logistic regression, followed by multivariable analysis. The lowest recorded PaO2 was used as a single data point for the determination of hypoxaemia and arterial oxygen partial pressure to fractional inspired oxygen ratio analysis.


RESULTS
Hypoxaemia was recorded in 23% horses undergoing exploratory laparotomy compared to 3.8% horses undergoing elective anaesthesia (P < 0.001). Multivariable analysis showed that weight above 550 kg, large intestinal lesions, and peak inspiratory pressure (PIP) above 30 cmH2 O were significantly associated with hypoxaemia in horses undergoing exploratory laparotomy. Soft tissue procedures and PIP > 30 cmH2 O were significantly associated with hypoxaemia during elective anaesthesia.


MAIN LIMITATIONS
This study only considered the minimum PaO2 recorded during anaesthesia. Duration and treatment of hypoxaemia were not considered.


CONCLUSIONS
Based on the lowest PaO2 value during anaesthesia, in our population, horses undergoing anaesthesia for exploratory laparotomy were over six times more likely to become hypoxaemic than horses undergoing elective procedures. Bodyweight, type of procedure and high PIP were predictors of hypoxaemia.}, journal={EQUINE VETERINARY JOURNAL}, author={Hovda, Tyne and Love, Lydia and Chiavaccini, Ludovica}, year={2021}, month={Dec} }