Lindsay Nichols

College of Sciences

2020 journal article

An artificial pathway for polyketide biosynthesis

Nature Catalysis, 3(7), 536–538.

By: A. Gayen n, L. Nichols n & G. Williams n

TL;DR: Some of the inefficiencies and limitations of these systems have been solved by designing an artificial pathway for carbon–carbon bond formation via iterative rounds of non-decarboxylative thio-Claisen reactions. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 3, 2020

2020 journal article

Synthetic biology enabling access to designer polyketides

Current Opinion in Chemical Biology, 58, 45–53.

By: A. Malico n, L. Nichols n & G. Williams n

author keywords: Polyketides; Synthetic biology; Metabolic engineering; Enzyme engineering; Natural products
MeSH headings : Genetic Engineering; Multigene Family; Polyketides / chemistry; Polyketides / metabolism; Synthetic Biology / methods
TL;DR: Recent successes in gene cluster discovery, host strain engineering, precursor-directed biosynthesis, combinatorial biosynthesis), polyketide tailoring, and high-throughput synthetic biology are discussed, as well as challenges and outlooks for rapidly generating useful target polyketides. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries
Added: December 22, 2020

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