Laurianne Chantal Van Landeghem
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Works (30)
Updated: November 23rd, 2024 05:02
2024 journal article
Prebiotic galactooligosaccharide improves piglet growth performance and intestinal health associated with alterations of the hindgut microbiota during the peri-weaning period
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, 15(1).
author keywords: Galactooligosaccharide; Gut microbiome; Intestinal villi; Prebiotics; Weaning
open access via jasbsci.biomedcentral.com (publisher PDF)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 15, 2024
2024 journal article
Protocol Protocol to culture enteric glial cells from the submucosal and myenteric plexi of neonatal and juvenile pig colons
STAR PROTOCOLS, 5(2).
Sources: Web Of Science, NC State University Libraries
Added: June 24, 2024
2023 article
Effects of Prebiotic Galactooligosaccharide (GOS) on Hindgut Microbial Composition of Pigs During the Peri-Weaning Period
Boston, T. E., Wang, F., Xi, L., Kim, S. W., Fellner, V., Scott, M. F., … Odle, J. (2023, November 6). JOURNAL OF ANIMAL SCIENCE, Vol. 101, pp. 187–188.
author keywords: microbiome; prebiotics; weaning
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023
2023 article
Effects of Prebiotic Galactooligosaccharide (Gos) on Piglet Growth and Jejunal Morphology During the Peri-Weaning Period
Boston, T. E., Wang, F., Xi, L., Kim, S. W., Fellner, V., Scott, M. F., … Odle, J. (2023, October 28). JOURNAL OF ANIMAL SCIENCE, Vol. 101, pp. 276–277.
author keywords: intestinal villi; galactooligosaccharides; prebiotics; weaning
Sources: Web Of Science, NC State University Libraries
Added: December 18, 2023
2023 journal article
Enteric glial cell network function is required for epithelial barrier restitution following intestinal ischemic injury in the early postnatal period
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 326(3), G228–G246.
author keywords: enteric glia; epithelial restitution; intestinal barrier; intestinal ischemia; restitution
TL;DR:
A neonatal phenotype characterized by a complete lack of coordinated reparative signaling in the mucosal microenvironment is confirmed and important evidence is reported that the subepithelial EGC network changes significantly over the early postnatal period and that proximity of a specific functional population of EGC to wounded intestinal epithelium contributes to intestinal barrier restitution following ischemic injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 12, 2024
2023 article
Mini-Review: Enteric glia of the tumor microenvironment: An affair of corruption
Mariant, C. L., Bacola, G., & Van Landeghem, L. (2023, September 25). NEUROSCIENCE LETTERS, Vol. 814.
author keywords: Enteric glial cell; Colon cancer; Tumor microenvironment; Cancer stem cell; Intestinal stem cell
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
16. Peace, Justice and Strong Institutions
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 4, 2024
2023 article
Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis (vol 49, pg 172, 2019)
Vales, S., Bacola, G., Biraud, M., Bessard, A., Geraldo, F., Dougherty, K. A., … Van Landeghem, L. (2023, February). EBIOMEDICINE, Vol. 88.
TL;DR:
This research attacked the mode of action of EMTs through a probabilistic route called “ ‘spiking’ the Tournaisian nervous system’ through a number of different mechanisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 27, 2023
2021 journal article
PCSK9 is not secreted from mature differentiated intestinal cells
JOURNAL OF LIPID RESEARCH, 62.
author keywords: intestine; cholesterol metabolism; lipoprotein metabolism; Caco-2 cell; liver-specific knockout; portal blood; systemic blood; Ussing chambers; PCSK9
MeSH headings : Animals; Caco-2 Cells; Cell Differentiation; Cells, Cultured; Humans; Intestine, Small / cytology; Intestine, Small / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Proprotein Convertase 9 / blood; Proprotein Convertase 9 / deficiency; Proprotein Convertase 9 / metabolism
TL;DR:
The data demonstrate that mature enterocytes do not secrete PCSK9 and reinforce the central role of the liver in the regulation the concentration of circulating PCSK 9 and consequently of cellular LDL receptors and direct comparison of systemic versus portal blood PC SK9 concentrations confirmed the inability of the small intestine to secretePCSK9 into the portal compartment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 4, 2021
2020 article
A Glial Cell Inhibitor Blocks Epithelial Barrier Repair in a Pig Model of Intestinal Ischemia
Sheridan, A., Pridgen, T., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.
TL;DR:
It is hypothesized that EGC inhibition in juveniles will block epithelial barrier repair after ischemic injury mimicking the neonatal phenotype, and the development of glial‐epithelial crosstalk in barrier repair will ultimately guide novel clinical solutions to improve outcomes in neonatal patients affected by intestinal injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 12, 2020
2020 article
Effects of Oligosaccharide Supplementation on Intestinal Morphology and Enteric Glial Cell Marker Expression in a Neonatal Pig Model
Shapiro, L., Ziegler, A., Odle, J., Van Landeghem, L., & Blikslager, A. (2020, April). FASEB JOURNAL, Vol. 34.
TL;DR:
Test the effects of dietary oligosaccharides on postnatal changes in the EGC network and intestinal morphology in a neonatal pig model to find increased mucosal expression of EGC markers earlier in postnatal development in the high oligOSaccharide group, as well as histological changes consistent with enhanced rates of gut maturation in pigs fed a high oligosACcharide diet.
(via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 12, 2020
2020 article
iDISCO Allows Complete Visualization and Analysis of Postnatal Enteric Nervous System Development in a Comparative Pig Model
Erwin, S., Touvron, M., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 12, 2020
2019 journal article
Nuclear envelope deformation controls cell cycle progression in response to mechanical force
EMBO REPORTS, 20(9).
author keywords: AP1; c-Jun; mechanotransduction; nuclear envelope; TEAD
MeSH headings : Cell Cycle / genetics; Cell Cycle / physiology; Cell Division / genetics; Cell Division / physiology; Cell Line; Cell Nucleus / genetics; Cell Nucleus / metabolism; Flow Cytometry; G1 Phase / genetics; G1 Phase / physiology; HeLa Cells; Humans; Mechanotransduction, Cellular / genetics; Mechanotransduction, Cellular / physiology; Microscopy, Atomic Force; Nuclear Envelope / genetics; Nuclear Envelope / metabolism; Plasmids / genetics; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; S Phase / genetics; S Phase / physiology; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
It is shown that applying compressive force on the nucleus in the absence of myosin II‐mediated tension is sufficient to restore G1 to S transition and reveal that the nuclear envelope can operate as a mechanical sensor whose deformation controls cell growth in response to tension.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 19, 2019
2018 journal article
Enteric glia: Diversity or plasticity?
BRAIN RESEARCH, 1693, 140–145.
author keywords: Enteric glial cells; Enteric nervous system
MeSH headings : Animals; Enteric Nervous System / cytology; Humans; Nerve Net / cytology; Neuroglia / classification; Neuroglia / physiology
TL;DR:
The development of tools and techniques to better appraise enteric glial cells heterogeneity and plasticity will undoubtedly unveil critical regulatory mechanisms implicated in gut health and disease, as well as disorders of the gut-brain axis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2018 journal article
Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair
PLOS ONE, 13(8), e0200674.
Contributors: A. Ziegler n , T. Pridgen n, J. Mills n, L. Gonzalez n , n, J. Odle n , A. Blikslager n
Ed(s): J. Karhausen
MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Epithelium / injuries; Epithelium / pathology; Intestinal Diseases / physiopathology; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Ischemia / physiopathology; Jejunum / injuries; Jejunum / physiology; Recovery of Function; Swine; Vascular Diseases / pathology; Vascular Diseases / prevention & control
TL;DR:
Findings support the hypothesis that a defect in mucosal repair in neonates is due to immature repair mechanisms within the mucosal compartment, and ex vivo exogenous application of injured juvenile mucosal homogenate produced a significant increase in TEER and enhanced histological restitution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: October 16, 2018
2018 journal article
Sa1664 - The Lin28B-Imp1 Axis Directs a Post-Transcriptional Regulon of Oncogenic Signaling in the Intestine
Gastroenterology, 154(6), S-346.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: February 21, 2020
2018 journal article
Su1056 - Unraveling Post-Transcriptional Regulation of Intestinal Response to Acute Challenge by the RNA Binding Protein IMP1
Gastroenterology, 154(6), S-470.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: February 21, 2020
2017 journal article
Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells
AGING-US, 9(8), 1898–1915.
author keywords: intestinal epithelial stem cells; aging; Sox9; organoid
MeSH headings : Age Factors; Aging / genetics; Aging / metabolism; Aging / pathology; Animals; Apoptosis; Cell Cycle; Cell Lineage; Cell Proliferation; Enterocytes / metabolism; Enterocytes / pathology; Epithelial Cells / metabolism; Epithelial Cells / pathology; Female; Gene Expression Regulation, Developmental; Genotype; Goblet Cells / metabolism; Goblet Cells / pathology; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Homeostasis; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Jejunum / metabolism; Jejunum / pathology; Lac Operon; Male; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Stress; Paneth Cells / metabolism; Paneth Cells / pathology; Phenotype; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; SOX9 Transcription Factor / genetics; SOX9 Transcription Factor / metabolism; Signal Transduction; Spheroids, Cellular; Stem Cells / metabolism; Stem Cells / pathology; Time Factors; Tissue Culture Techniques
TL;DR:
New, direct evidence for aging associated IESC dysfunction is provided, and potential biomarkers and targets for translational studies to assess and maintain IesC function during aging are defined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System
Cellular and Molecular Gastroenterology and Hepatology, 5(1), 31–49.
author keywords: Colorectal Cancer; Enteric Neurons; Adhesion; Migration
TL;DR:
The data show that the enteric neuronal network guides tumor cell migration, partly via L1CAM and N-cadherin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 21, 2020
2016 journal article
The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn’s disease
Scientific Reports, 6(1).
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Aldo-Keto Reductase Family 1 Member C3 / metabolism; Caco-2 Cells; Cells, Cultured; Coculture Techniques; Crohn Disease / metabolism; Dinoprost / metabolism; Eicosapentaenoic Acid / analogs & derivatives; Eicosapentaenoic Acid / metabolism; Epithelial Cells / cytology; Epithelial Cells / metabolism; Female; Humans; Hydroxyeicosatetraenoic Acids / metabolism; Intestinal Mucosa / metabolism; Intestines / cytology; Male; Middle Aged; Prostaglandin D2 / analogs & derivatives; Prostaglandin D2 / metabolism; Wound Healing; Young Adult
TL;DR:
CD EGC presented impaired ability to promote IEB functions through defect in L-PGDS-AKR1C3-11βPGF2α dependent pathway, which is similar to that presented by healthy EGC.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2016 journal article
Tu1850 Direct Regulation of Crypt Autophagy and Intestinal Homeostasis via mRNA Binding Protein Imp1
Gastroenterology, 150(4), S960.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: February 24, 2020
2014 journal article
Enteric Glial Cells: Recent Developments and Future Directions
Gastroenterology, 147(6), 1230–1237.
author keywords: Enteric Nervous System; Intestinal Epithelial Barrier; Enteric Neuron
MeSH headings : Enteric Nervous System / cytology; Homeostasis; Humans; Intestinal Diseases / pathology; Intestinal Mucosa / cytology; Intestinal Mucosa / innervation; Neuroglia / cytology
TL;DR:
Emerging concepts as to how EGCs regulate neuromediator expression, exert neuroprotective roles, and even act as neuronal as well as glial progenitors in the enteric nervous system are summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2014 journal article
Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus
Nature Cell Biology, 16(4), 376–381.
MeSH headings : Cell Line; Cell Nucleus / genetics; Cell Nucleus / physiology; Chromatin / metabolism; Cytoskeletal Proteins; Cytoskeleton / metabolism; DNA / metabolism; Focal Adhesion Kinase 1 / antagonists & inhibitors; HeLa Cells; Histone Deacetylase Inhibitors / pharmacology; Humans; Hydroxamic Acids / pharmacology; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Mechanotransduction, Cellular / physiology; Membrane Proteins / genetics; Membrane Proteins / metabolism; Microtubule-Associated Proteins / genetics; Microtubule-Associated Proteins / metabolism; Nerve Tissue Proteins / metabolism; Nuclear Lamina / physiology; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Phosphorylation; Proto-Oncogene Proteins c-abl / antagonists & inhibitors; RNA Interference; RNA, Small Interfering; Stress, Mechanical
TL;DR:
The results demonstrate that mechanotransduction is not restricted to cell surface receptors and adhesions but can occur in the nucleus, and applying force on nesprin-1 triggers nuclear stiffening that does not involve chromatin or nuclear actin, but requires an intact nuclear lamina and emerin, a protein of the inner nuclear membrane.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
Ileocecal resection (ICR)-driven crypt fission requires intestinal epithelial IGF-1 receptor, is increased with delayed IGF-1 therapy, and results in sustained adaptive increases in body weight and intestinal length
Journal of the American College of Surgeons, 215(3), S77.
TL;DR:
Obese patients were more likely older, black or Hispanic, living in lower income neighborhoods, and using Medicaid, and more likely to undergo laparoscopic appendectomy than non-obese patients.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: January 21, 2021
2012 journal article
The digestive neuronal–glial–epithelial unit: a new actor in gut health and disease
Nature Reviews Gastroenterology & Hepatology, 10(2), 90–100.
MeSH headings : Animals; Cell Membrane Permeability / physiology; Cell Proliferation; Enteric Nervous System / cytology; Enteric Nervous System / physiology; Gastrointestinal Diseases / pathology; Gastrointestinal Diseases / physiopathology; Gastrointestinal Tract / cytology; Gastrointestinal Tract / physiology; Homeostasis / physiology; Humans; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Neuroglia / cytology; Neuroglia / physiology; Neurons / cytology; Neurons / physiology; Wound Healing / physiology
TL;DR:
Findings demonstrating that the ENS is a key regulator of IEB function and is actively involved in pathologies associated with altered barrier function are summarized.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Increased Expression of Insulin Receptor Isoform a (IR-a) and Insulin Receptor Substrate 1 (IRS1) in Poorly Differentiated Colon Cancer Cell Lines and APC MIN/+ Tumors
Gastroenterology, 140(5), S-822.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Insulin-Like Growth Factor-I Promotes Intestinal Stem Cell Expansion During Crypt Regeneration and Mucosal Healing Following Radiation
Gastroenterology, 140(5), S-39.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2011 journal article
Serum amyloid factor A3: A putative marker of intestinal stem cell expansion
Journal of the American College of Surgeons, 213(3), S78.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2010 journal article
MS516 Unusual Sterolic Mixture, and 24-isopropylcholesterol, from the sponge Ciocalypta sp. reduce cholesterol uptake and basolateral secretion in Caco2 cells
Atherosclerosis Supplements, 11(2), 213.
Source: Crossref
Added: February 12, 2021
2009 journal article
Unusual sterolic mixture, and 24-isopropylcholesterol, from the spongeCiocalyptasp. reduce cholesterol uptake and basolateral secretion in Caco-2 cells
Journal of Cellular Biochemistry, 106(4), 659–665.
author keywords: STEROLS; CHOLESTEROL; 24-ISOPROPYLCHOLESTEROL; INTESTINAL CHOLESTEROL ABSORPTION; CACO-2 CELLS; MARINE SPONGE; HALICHONDRIIDAE; ABCA1; ACAT-2
MeSH headings : Animals; Caco-2 Cells; Cholesterol / metabolism; Dehydrocholesterols / pharmacology; Humans; Intestinal Absorption / drug effects; Porifera; RNA, Messenger / analysis; Sitosterols / pharmacology; Sterol O-Acyltransferase / genetics; Sterols / pharmacology
TL;DR:
A new sterol, 24‐isopropylcholesterol, is added to sterols that may reduce intestinal cholesterol absorption and increase the expression of ABCA1 mRNA in Caco‐2 cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Crossref
Added: January 24, 2021
2008 journal article
T1820 Enteric Glial Cells Promote Wound Healing of Intestinal Epithelial Barrier in Part Via a FAK-Dependent Pathway
Gastroenterology, 134(4), A-570.
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: Crossref
Added: August 28, 2020
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