Works (24)

Updated: July 22nd, 2023 21:17

2023 article

Tumor cells hijack enteric glia to activate colon cancer stem cells and stimulate tumorigenesis (vol 49, pg 172, 2019)

Vales, S., Bacola, G., Biraud, M., Bessard, A., Geraldo, F., Dougherty, K. A., … Van Landeghem, L. (2023, February). EBIOMEDICINE, Vol. 88.

By: S. Vales, G. Bacola*, M. Biraud*, A. Bessard, F. Geraldo, K. Dougherty, S. Lashani, C. Bossard ...

Sources: Web Of Science, ORCID
Added: February 27, 2023

2021 journal article

PCSK9 is not secreted from mature differentiated intestinal cells

JOURNAL OF LIPID RESEARCH, 62.

By: M. Francois*, A. Thedrez*, D. Garcon*, A. Ayer*, T. Sotin*, W. Dijk*, C. Blanchard*, G. Chadeuf* ...

author keywords: intestine; cholesterol metabolism; lipoprotein metabolism; Caco-2 cell; liver-specific knockout; portal blood; systemic blood; Ussing chambers; PCSK9
MeSH headings : Animals; Caco-2 Cells; Cell Differentiation; Cells, Cultured; Humans; Intestine, Small / cytology; Intestine, Small / metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Proprotein Convertase 9 / blood; Proprotein Convertase 9 / deficiency; Proprotein Convertase 9 / metabolism
Source: Web Of Science
Added: October 4, 2021

2020 article

A Glial Cell Inhibitor Blocks Epithelial Barrier Repair in a Pig Model of Intestinal Ischemia

Sheridan, A., Pridgen, T., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.

By: A. Sheridan*, T. Pridgen*, J. Odle*, L. Van Landeghem*, A. Blikslager* & A. Ziegler*

Sources: Web Of Science, ORCID
Added: October 12, 2020

2020 article

Effects of Oligosaccharide Supplementation on Intestinal Morphology and Enteric Glial Cell Marker Expression in a Neonatal Pig Model

Shapiro, L., Ziegler, A., Odle, J., Van Landeghem, L., & Blikslager, A. (2020, April). FASEB JOURNAL, Vol. 34.

By: L. Shapiro n, A. Ziegler n, J. Odle n, L. Van Landeghem n & A. Blikslager n

Sources: Web Of Science, ORCID
Added: October 12, 2020

2020 article

iDISCO Allows Complete Visualization and Analysis of Postnatal Enteric Nervous System Development in a Comparative Pig Model

Erwin, S., Touvron, M., Odle, J., Van Landeghem, L., Blikslager, A., & Ziegler, A. (2020, April). FASEB JOURNAL, Vol. 34.

By: S. Erwin n, M. Touvron*, J. Odle n, L. Van Landeghem n, A. Blikslager n & A. Ziegler n

Sources: Web Of Science, ORCID
Added: October 12, 2020

2019 journal article

Nuclear envelope deformation controls cell cycle progression in response to mechanical force

EMBO REPORTS, 20(9).

By: J. Aureille*, V. Buffiere-Ribot*, B. Harvey*, C. Boyault*, L. Pernet*, T. Andersen*, G. Bacola n, M. Balland* ...

author keywords: AP1; c-Jun; mechanotransduction; nuclear envelope; TEAD
MeSH headings : Cell Cycle / genetics; Cell Cycle / physiology; Cell Division / genetics; Cell Division / physiology; Cell Line; Cell Nucleus / genetics; Cell Nucleus / metabolism; Flow Cytometry; G1 Phase / genetics; G1 Phase / physiology; HeLa Cells; Humans; Mechanotransduction, Cellular / genetics; Mechanotransduction, Cellular / physiology; Microscopy, Atomic Force; Nuclear Envelope / genetics; Nuclear Envelope / metabolism; Plasmids / genetics; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; S Phase / genetics; S Phase / physiology; Transcription Factors / genetics; Transcription Factors / metabolism
Sources: Web Of Science, ORCID
Added: August 19, 2019

2018 journal article

Colorectal Cancer Cells Adhere to and Migrate Along the Neurons of the Enteric Nervous System

Cellular and Molecular Gastroenterology and Hepatology, 5(1), 31–49.

By: E. Duchalais*, C. Guilluy*, S. Nedellec*, M. Touvron*, A. Bessard*, Y. Touchefeu*, C. Bossard*, H. Boudin* ...

author keywords: Colorectal Cancer; Enteric Neurons; Adhesion; Migration
Source: Crossref
Added: February 21, 2020

2018 journal article

Enteric glia: Diversity or plasticity?

BRAIN RESEARCH, 1693, 140–145.

By: S. Vales*, M. Touvron n & L. Van Landeghem n

author keywords: Enteric glial cells; Enteric nervous system
MeSH headings : Animals; Enteric Nervous System / cytology; Humans; Nerve Net / cytology; Neuroglia / classification; Neuroglia / physiology
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Epithelial restitution defect in neonatal jejunum is rescued by juvenile mucosal homogenate in a pig model of intestinal ischemic injury and repair

PLOS ONE, 13(8), e0200674.

By: A. Ziegler n, T. Pridgen n, J. Mills n, L. Gonzalez n, L. Van Landeghem n, J. Odle n, A. Blikslager n

Ed(s): J. Karhausen

MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Epithelium / injuries; Epithelium / pathology; Intestinal Diseases / physiopathology; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Ischemia / physiopathology; Jejunum / injuries; Jejunum / physiology; Recovery of Function; Swine; Vascular Diseases / pathology; Vascular Diseases / prevention & control
Sources: Web Of Science, Crossref, ORCID
Added: October 16, 2018

2018 journal article

Sa1664 - The Lin28B-Imp1 Axis Directs a Post-Transcriptional Regulon of Oncogenic Signaling in the Intestine

Gastroenterology, 154(6), S-346.

By: P. Chatterji, K. Hamilton, S. Liang, S. Andres, H. Wijeratne, R. Mizuno, L. Simon, P. Hicks ...

Source: Crossref
Added: February 21, 2020

2018 journal article

Su1056 - Unraveling Post-Transcriptional Regulation of Intestinal Response to Acute Challenge by the RNA Binding Protein IMP1

Gastroenterology, 154(6), S-470.

By: P. Chatterji, L. Simon, S. Andres, R. Mizuno, E. Lundsmith, L. Chau, V. Giroux, A. Mah ...

Source: Crossref
Added: February 21, 2020

2017 journal article

Aging effects on intestinal homeostasis associated with expansion and dysfunction of intestinal epithelial stem cells

AGING-US, 9(8), 1898–1915.

author keywords: intestinal epithelial stem cells; aging; Sox9; organoid
MeSH headings : Age Factors; Aging / genetics; Aging / metabolism; Aging / pathology; Animals; Apoptosis; Cell Cycle; Cell Lineage; Cell Proliferation; Enterocytes / metabolism; Enterocytes / pathology; Epithelial Cells / metabolism; Epithelial Cells / pathology; Female; Gene Expression Regulation, Developmental; Genotype; Goblet Cells / metabolism; Goblet Cells / pathology; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Homeostasis; Intestinal Mucosa / metabolism; Intestinal Mucosa / pathology; Jejunum / metabolism; Jejunum / pathology; Lac Operon; Male; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Stress; Paneth Cells / metabolism; Paneth Cells / pathology; Phenotype; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; SOX9 Transcription Factor / genetics; SOX9 Transcription Factor / metabolism; Signal Transduction; Spheroids, Cellular; Stem Cells / metabolism; Stem Cells / pathology; Time Factors; Tissue Culture Techniques
Source: Web Of Science
Added: August 6, 2018

2016 journal article

The arachidonic acid metabolite 11β-ProstaglandinF2α controls intestinal epithelial healing: deficiency in patients with Crohn’s disease

Scientific Reports, 6(1).

By: S. Coquenlorge*, L. Van Landeghem*, J. Jaulin*, N. Cenac*, N. Vergnolle*, E. Duchalais*, M. Neunlist*, M. Rolli-Derkinderen*

MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Aldo-Keto Reductase Family 1 Member C3 / metabolism; Caco-2 Cells; Cells, Cultured; Coculture Techniques; Crohn Disease / metabolism; Dinoprost / metabolism; Eicosapentaenoic Acid / analogs & derivatives; Eicosapentaenoic Acid / metabolism; Epithelial Cells / cytology; Epithelial Cells / metabolism; Female; Humans; Hydroxyeicosatetraenoic Acids / metabolism; Intestinal Mucosa / metabolism; Intestines / cytology; Male; Middle Aged; Prostaglandin D2 / analogs & derivatives; Prostaglandin D2 / metabolism; Wound Healing; Young Adult
Source: Crossref
Added: August 28, 2020

2016 journal article

Tu1850 Direct Regulation of Crypt Autophagy and Intestinal Homeostasis via mRNA Binding Protein Imp1

Gastroenterology, 150(4), S960.

By: K. Hamilton, P. Chatterji, S. Andres, K. Whelan, E. Lundsmith, R. Mizuno, V. Giroux, A. Mah ...

Source: Crossref
Added: February 24, 2020

2014 journal article

Enteric Glial Cells: Recent Developments and Future Directions

Gastroenterology, 147(6), 1230–1237.

author keywords: Enteric Nervous System; Intestinal Epithelial Barrier; Enteric Neuron
MeSH headings : Enteric Nervous System / cytology; Homeostasis; Humans; Intestinal Diseases / pathology; Intestinal Mucosa / cytology; Intestinal Mucosa / innervation; Neuroglia / cytology
Source: Crossref
Added: August 28, 2020

2014 journal article

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

Nature Cell Biology, 16(4), 376–381.

By: C. Guilluy*, L. Osborne*, L. Van Landeghem*, L. Sharek*, R. Superfine*, R. Garcia-Mata*, K. Burridge*

MeSH headings : Cell Line; Cell Nucleus / genetics; Cell Nucleus / physiology; Chromatin / metabolism; Cytoskeletal Proteins; Cytoskeleton / metabolism; DNA / metabolism; Focal Adhesion Kinase 1 / antagonists & inhibitors; HeLa Cells; Histone Deacetylase Inhibitors / pharmacology; Humans; Hydroxamic Acids / pharmacology; Intracellular Signaling Peptides and Proteins / genetics; Intracellular Signaling Peptides and Proteins / metabolism; Mechanotransduction, Cellular / physiology; Membrane Proteins / genetics; Membrane Proteins / metabolism; Microtubule-Associated Proteins / genetics; Microtubule-Associated Proteins / metabolism; Nerve Tissue Proteins / metabolism; Nuclear Lamina / physiology; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Phosphorylation; Proto-Oncogene Proteins c-abl / antagonists & inhibitors; RNA Interference; RNA, Small Interfering; Stress, Mechanical
Source: Crossref
Added: August 28, 2020

2012 journal article

Ileocecal resection (ICR)-driven crypt fission requires intestinal epithelial IGF-1 receptor, is increased with delayed IGF-1 therapy, and results in sustained adaptive increases in body weight and intestinal length

Journal of the American College of Surgeons, 215(3), S77.

By: M. Stevenson*, J. Hawkins*, N. Sundaram*, P. Lund*, L. Van Landeghem* & M. Helmrath*

Source: Crossref
Added: January 21, 2021

2012 journal article

The digestive neuronal–glial–epithelial unit: a new actor in gut health and disease

Nature Reviews Gastroenterology & Hepatology, 10(2), 90–100.

MeSH headings : Animals; Cell Membrane Permeability / physiology; Cell Proliferation; Enteric Nervous System / cytology; Enteric Nervous System / physiology; Gastrointestinal Diseases / pathology; Gastrointestinal Diseases / physiopathology; Gastrointestinal Tract / cytology; Gastrointestinal Tract / physiology; Homeostasis / physiology; Humans; Intestinal Mucosa / cytology; Intestinal Mucosa / physiology; Neuroglia / cytology; Neuroglia / physiology; Neurons / cytology; Neurons / physiology; Wound Healing / physiology
Source: Crossref
Added: August 28, 2020

2011 journal article

Increased Expression of Insulin Receptor Isoform a (IR-a) and Insulin Receptor Substrate 1 (IRS1) in Poorly Differentiated Colon Cancer Cell Lines and APC MIN/+ Tumors

Gastroenterology, 140(5), S-822.

By: S. Bortvedt, M. Santoro, A. Mah, J. Simmons, L. Van Landeghem* & P. Lund

Source: Crossref
Added: August 28, 2020

2011 journal article

Insulin-Like Growth Factor-I Promotes Intestinal Stem Cell Expansion During Crypt Regeneration and Mucosal Healing Following Radiation

Gastroenterology, 140(5), S-39.

By: L. Van Landeghem*, M. Santoro, A. Krebs, A. Mah, J. Dehmer, A. Gracz, S. Magness, P. Lund

Source: Crossref
Added: August 28, 2020

2011 journal article

Serum amyloid factor A3: A putative marker of intestinal stem cell expansion

Journal of the American College of Surgeons, 213(3), S78.

By: J. Dehmer*, K. Speck*, L. Van Landeghem*, J. Hawkins*, P. Lund* & M. Helmrath*

Source: Crossref
Added: August 28, 2020

2010 journal article

MS516 Unusual Sterolic Mixture, and 24-isopropylcholesterol, from the sponge Ciocalypta sp. reduce cholesterol uptake and basolateral secretion in Caco2 cells

Atherosclerosis Supplements, 11(2), 213.

By: Q. Do, L. Landeghem, G. Wielgosz-Collin, M. Takoudju, J. Huvelin, J. Kornprobst, J. Bard, G. Barnathan, H. Nazih

Source: Crossref
Added: February 12, 2021

2009 journal article

Unusual sterolic mixture, and 24-isopropylcholesterol, from the spongeCiocalyptasp. reduce cholesterol uptake and basolateral secretion in Caco-2 cells

Journal of Cellular Biochemistry, 106(4), 659–665.

By: H. Do, L. Van Landeghem*, G. Wielgosz-Collin*, M. Takoudju*, J. Huvelin*, J. Kornprobst*, J. Bard*, G. Barnathan*, H. Nazih*

author keywords: STEROLS; CHOLESTEROL; 24-ISOPROPYLCHOLESTEROL; INTESTINAL CHOLESTEROL ABSORPTION; CACO-2 CELLS; MARINE SPONGE; HALICHONDRIIDAE; ABCA1; ACAT-2
MeSH headings : Animals; Caco-2 Cells; Cholesterol / metabolism; Dehydrocholesterols / pharmacology; Humans; Intestinal Absorption / drug effects; Porifera; RNA, Messenger / analysis; Sitosterols / pharmacology; Sterol O-Acyltransferase / genetics; Sterols / pharmacology
Source: Crossref
Added: January 24, 2021

2008 journal article

T1820 Enteric Glial Cells Promote Wound Healing of Intestinal Epithelial Barrier in Part Via a FAK-Dependent Pathway

Gastroenterology, 134(4), A-570.

By: L. Van Landeghem*, P. Derkinderen, P. Aubert, H. Enslen, I. Guisle-Marsollier, J. Léger, J. Galmiche, T. Savidge, M. Neunlist

Source: Crossref
Added: August 28, 2020