Works (60)

Updated: April 4th, 2024 17:45

2010 journal article

Expression of IL-4/IL-13 receptors in differentiating human airway epithelial cells

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 299(5), L681–L693.

By: S. White*, L. Martin n, R. Stern*, B. Laxman* & B. Marroquin*

author keywords: interleukin-4; interleukin-13; eotaxin-3; migration
MeSH headings : Animals; Cell Differentiation / physiology; Cell Movement; Cells, Cultured; Chemokine CCL26; Chemokines, CC / genetics; Chemokines, CC / metabolism; Epithelial Cells / cytology; Epithelial Cells / physiology; Humans; Protein Subunits / genetics; Protein Subunits / metabolism; Receptors, Interleukin-13 / genetics; Receptors, Interleukin-13 / metabolism; Receptors, Interleukin-4 / genetics; Receptors, Interleukin-4 / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / physiology; Stress, Mechanical
TL;DR: Substantial differences in IL-4/IL-13 receptor subunit expression and responsiveness toIL-4 based on the extent of airway epithelial cell differentiation are demonstrated and it is suggested that these differences may have functional consequences in airway inflammation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Susceptibility of Inflamed Alveolar and Airway Epithelial Cells to Injury Induced by Diesel Exhaust Particles of Varying Organic Carbon Content

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 73(8), 565–580.

By: N. Manzo n, R. Slade*, J. Richards*, J. McGee*, L. Martin n & J. Dye*

MeSH headings : Actins / metabolism; Air Pollutants / chemistry; Air Pollutants / toxicity; Animals; Carbon / toxicity; Cells, Cultured; Glutathione / metabolism; Heme Oxygenase-1 / metabolism; L-Lactate Dehydrogenase / metabolism; Mice; Particulate Matter / chemistry; Particulate Matter / toxicity; Pulmonary Alveoli / drug effects; Respiratory Mucosa / cytology; Respiratory Mucosa / drug effects; Vehicle Emissions / toxicity
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Insulin receptor substrate-1/2 mediates IL-4-induced migration of human airway epithelial cells

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 297(1), L164–L173.

By: S. White, L. Martin*, M. Abe, B. Marroquin, R. Stern & X. Fu*

author keywords: epithelium; interleukin-4; STAT6; IRS-1; IRS-2
MeSH headings : Air; Cell Differentiation / drug effects; Cell Line; Cell Movement / drug effects; DNA, Complementary / genetics; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Genes, Dominant; Humans; Insulin Receptor Substrate Proteins / metabolism; Interleukin-4 / pharmacology; Lung / cytology; Lung / pathology; Phosphorylation / drug effects; RNA, Small Interfering / metabolism; STAT6 Transcription Factor / metabolism
TL;DR: It is demonstrated that IL-4 can accelerate migration of differentiated AEC after injury, and this reparative response does not require STAT6 activation, but rather requires IRS-1 and/or IRS-2. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

IL-13-induced proliferation of airway epithelial cells: mediation by intracellular growth factor mobilization and ADAM17

Respiratory Research, 8.

By: B. Booth, T. Sandifer, E. Martin & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2007 patent

Method and compositions for altering mucus secretion

Washington, DC: U.S. Patent and Trademark Office.

By: Y. Li, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Differential Muc2 and Muc5ac secretion by stimulated guinea pig tracheal epithelial cells in vitro

Respiratory Research, 7, 35.

By: B. Chorley, A. Crews, Y. Li, K. Adler, M. Minnicozzi & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2006 patent

Methods for regulating inflammatory mediators and peptides useful therein

Washington, DC: U.S. Patent and Trademark Office.

By: S. Takashi, I. Parikh, K. Adler, L. Martin & L. Y.

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Pulmonary lesions in cats with diabetes mellitus

JOURNAL OF VETERINARY INTERNAL MEDICINE, 20(1), 47–51.

By: A. Mexas n, R. Hess*, E. Hawkins n & L. Martin n

author keywords: complications of diabetes mellitus; feline; lung histopathology
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 patent

Culture system for mouse tracheal epithelial cells

Washington, DC: U.S. Patent and Trademark Office.

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure

FASEB Journal, 19(7).

By: B. Fischer, J. Cuellar, A. Byrd, A. Rice, J. Bonner, L. Martin, J. Voynow

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Human neutrophil elastase induces hypersecretion of mucin from well-differentiated human bronchial epithelial cells in vitro via a protein kinase C delta-mediated mechanism

AMERICAN JOURNAL OF PATHOLOGY, 167(3), 651–661.

By: J. Park n, F. He n, L. Martin n, Y. Li n, B. Chorley n & K. Adler n

MeSH headings : Bronchi / cytology; Bronchi / drug effects; Bronchi / metabolism; Cell Differentiation; Cells, Cultured; Enzyme Activation / drug effects; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Humans; Isoenzymes / metabolism; Leukocyte Elastase / pharmacology; Mucins / metabolism; Protein Kinase C / metabolism; Protein Kinase C / physiology; Protein Kinase C-delta; Protein Kinase Inhibitors / pharmacology
TL;DR: The results suggest HNE stimulation of mucin release by human airway epithelial cells involves intracellular activation of PKC, specifically the delta isoform. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 171(4), 305–314.

By: H. Deshmukh n, L. Case n, S. Wesselkamper n, M. Borchers n, L. Martin n, H. Shertzer n, J. Nadel n, G. Leikauf n

author keywords: bronchitis; emphysema; human bronchial epithelial cells; mucin
MeSH headings : Acrolein / pharmacology; Blotting, Western; Cells, Cultured; ErbB Receptors / drug effects; ErbB Receptors / metabolism; Glutathione / metabolism; Humans; Metalloproteases / metabolism; Mitogen-Activated Protein Kinases / metabolism; Mucin 5AC; Mucins / drug effects; Mucins / genetics; Mucins / metabolism; Oxidative Stress / physiology; Polymerase Chain Reaction / methods; RNA, Messenger / biosynthesis; RNA, Messenger / drug effects; Up-Regulation / drug effects
TL;DR: Together, data suggest that acrolein induces MUC5AC expression via an initial ligand-dependent activation of EGFR mediated by ADAM17 and MMP9 and TIMP3 transcription, and that a prolonged effect of acrole in NCI-H292 cells may be mediated by altering MMP 9 and TIMp3 transcription. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Modeling the airway epithelium in allergic asthma: Interleukin-13-induced effects in differentiated murine tracheal epithelial cells

In Vitro Cellular & Developmental Biology. Animal, 41(7), 217–224.

By: S. Lankford, M. Macchione, A. Crews, S. McKane, N. Akley & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Viability of glycerol-preserved and cryopreserved anuran skin

In Vitro Cellular & Developmental Biology. Animal, 41(09-Aug), 258–263.

By: S. Willens, M. Stoskopf, L. Martin & G. Lewbart

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

A MARCKS-related peptide blocks mucus hypersecretion in a mouse model of asthma

NATURE MEDICINE, 10(2), 193–196.

By: M. Singer*, L. Martin n, B. Vargaftig*, J. Park n, A. Gruber, Y. Li n, K. Adler n

MeSH headings : Animals; Asthma / metabolism; Bronchi / cytology; Bronchi / metabolism; Bronchi / pathology; Bronchial Provocation Tests; Cytoplasmic Granules / metabolism; Cytoplasmic Granules / ultrastructure; Disease Models, Animal; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mucins / metabolism; Mucus / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Ovalbumin / administration & dosage; Ovalbumin / immunology; Peptide Fragments / administration & dosage; Peptide Fragments / chemistry; Peptide Fragments / pharmacology; Peptides / administration & dosage; Peptides / chemistry; Peptides / pharmacology; Proteins / chemistry; Proteins / genetics; Proteins / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / metabolism
TL;DR: It is shown that the intratracheal instillation of this peptide blocks mucus hypersecretion in a mouse model of asthma, and a pivotal role for MARCKS protein, specifically its N-terminal region, in modulating this secretory process in mammalian airways is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 patent

Blocking peptide for inflammatory cell secretion

Washington, DC: U.S. Patent and Trademark Office.

By: L. Martin, K. Adler & Y. Li

Source: NC State University Libraries
Added: August 6, 2018

2003 article

A myristoylated peptide directed against the N-terminal region of MARCKS protein inhibits mucin secretion in ovalbumin sensitized/challenged mice in vivo.

American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A17.

By: B. Vargaftig, M. Singer, L. Martin, Y. Li & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2003 article

Differential effects of albuterol isomers on normal human bronchial epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A205.

By: B. Chorley, L. Martin, A. Crews, Y. Li & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Effects of TNF alpha on expression of ICAM-1 in human airway epithelial cells in vitro: Oxidant-mediated pathways and transcription factors

FREE RADICAL BIOLOGY AND MEDICINE, 35(9), 1158–1167.

By: T. Krunkosky n, L. Martin n, B. Fischer n, J. Voynow* & K. Adler n

author keywords: intercellular adhesion molecule 1; normal human bronchial epithelial cells; nuclear factor kappa beta; CAAT/enhancer binding protein; free radicals
MeSH headings : Antioxidants / pharmacology; Antioxidants / toxicity; Bronchi / cytology; CCAAT-Enhancer-Binding Proteins / metabolism; Cell Line; Consensus Sequence / genetics; Cysteine Endopeptidases / metabolism; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Gene Expression Regulation / drug effects; Humans; Intercellular Adhesion Molecule-1 / genetics; Leupeptins / pharmacology; Multienzyme Complexes / antagonists & inhibitors; Multienzyme Complexes / metabolism; NF-kappa B / metabolism; Oxidants / metabolism; Promoter Regions, Genetic / genetics; Proteasome Endopeptidase Complex; Pyrrolidines / pharmacology; Pyrrolidines / toxicity; RNA, Messenger / genetics; RNA, Messenger / metabolism; Reactive Oxygen Species / metabolism; Response Elements / genetics; Signal Transduction / drug effects; Thiocarbamates / pharmacology; Thiocarbamates / toxicity; Thiourea / analogs & derivatives; Thiourea / pharmacology; Thiourea / toxicity; Transcription Factors / metabolism; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: Results suggest that although TNFα enhances binding of C/EBP and NFκB complexes in NHBE cells, C-EBP binding seems to involve an oxidant-dependent mechanism, whereas activation of NFκBs complexes utilizes the ubiquitin-proteasome pathway, a mechanism that seems to be unaltered by the presence of antioxidants. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 article

Human neutrophil elastase provokes release of MUC5B mucin from normal bronchial epithelial cells in vitro via a PKC-dependent mechanism.

American Journal of Respiratory and Critical Care Medicine, Vol. 167, p. A203.

By: J. Park, F. He, Y. Li, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

PI3K signaling is required for prostaglandin-induced mucosal recovery in ischemia-injured porcine ileum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 284(1), G46–G56.

By: D. Little*, R. Dean, K. Young*, S. McKane n, L. Martin n, S. Jones*, A. Blikslager*

author keywords: phosphatidylinositol 3-kinase; tight junction; occludin; zonula occludens-1
MeSH headings : 16,16-Dimethylprostaglandin E2 / pharmacology; Animals; Anti-Ulcer Agents / pharmacology; Electric Impedance; Epoprostenol / analogs & derivatives; Epoprostenol / pharmacology; Female; Humans; Ileum / metabolism; Intestinal Mucosa / enzymology; Intestinal Mucosa / ultrastructure; Ischemia / metabolism; Male; Membrane Proteins / metabolism; Microscopy, Electron; Occludin; Osmotic Pressure; Phosphatidylinositol 3-Kinases / metabolism; Phosphoproteins / metabolism; Platelet Aggregation Inhibitors / pharmacology; Recovery of Function / physiology; Signal Transduction / drug effects; Signal Transduction / physiology; Swine; Tight Junctions / enzymology; Urea / pharmacology; Zonula Occludens-1 Protein
TL;DR: These experiments suggest that PGs stimulate recovery of paracellular resistance via a mechanism involving transepithelial osmotic gradients and PI3K-dependent restoration of tight junction protein distribution. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2003 article

Proliferation of the airway epithelium in asthma - Are inflammatory cells required?

Booth, B. W., Newcomb, D. C., McKane, S. A., Crews, A. L., Adler, K. B., Bonner, J. C., & Martin, L. D. (2003, March). CHEST, Vol. 123, pp. 384S–385S.

By: B. Booth n, D. Newcomb n, S. McKane n, A. Crews n, K. Adler n, J. Bonner*, L. Martin n

MeSH headings : Asthma / pathology; Asthma / physiopathology; Cell Physiological Phenomena; Humans; In Vitro Techniques; Inflammation / pathology; Inflammation / physiopathology; Respiratory Mucosa / pathology; Respiratory Mucosa / physiopathology
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 article

IL-13 induces intracellular translocation and release of TGF? in human bronchial epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 165, p. A814.

By: B. Booth, K. Adler & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2002 journal article

Secretion-competent mouse tracheal epithelial cell culture from the genetically altered mouse - Pathway analysis via gene array

Chest, 121(3), 79S.

By: L. Martin n, K. Adler n, N. Akley n, A. Crews n & L. Sharova*

TL;DR: This work presents a new Epithelial Repair Model of In Vitro Gene Expression in an http://chestjournal.chestpubs.org/content/121/3_suppl/79S.xhtml ( distributed without the prior written permission of the copyright holder). (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

2001 article

Autocrine production of TGFa mediates interleukin 13-induced proliferation of human airway epithelial cells during development of a mucous phenotype in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 163, p. A738.

By: B. Booth, J. Bonner, K. Adler & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2001 article

Differentiation of murine tracheal epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 163, p. A225.

By: M. Macchione, N. Akley, K. Adler & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Encapsulation, permeability, and cellular uptake characteristics of hollow nanometer-sized conductive polymer capsules

JOURNAL OF PHYSICAL CHEMISTRY B, 105(37), 8872–8876.

By: S. Marinakos n, M. Anderson n, J. Ryan n, L. Martin n & D. Feldheim n

Source: Web Of Science
Added: August 6, 2018

2001 journal article

Enhanced expression of mucin genes in a guinea pig model of allergic asthma

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 25(5), 644–651.

By: Y. Li n, L. Martin n, M. Minnicozzi n, S. Greenfeder n, J. Fine n, C. Pettersen n, B. Chorley n, K. Adler n

MeSH headings : Amino Acid Sequence; Animals; Antineoplastic Agents / pharmacology; Asthma / physiopathology; Base Sequence; Bronchial Hyperreactivity / physiopathology; Cells, Cultured; Chemokine CCL11; Chemokines, CC / genetics; Cloning, Molecular; Conserved Sequence; Disease Models, Animal; Eosinophils / immunology; Gene Expression / physiology; Guinea Pigs; Histamine / pharmacology; Hypersensitivity / physiopathology; Inflammation Mediators / pharmacology; Molecular Sequence Data; Mucin 5AC; Mucin-2; Mucins / genetics; Ovalbumin / immunology; Ovalbumin / pharmacology; RNA, Messenger / analysis; Respiratory Mucosa / cytology; Respiratory Mucosa / physiology; Trachea / cytology; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: Results of these studies suggest that the OVA-sensitized guinea pig responds to allergic challenge with enhanced expression of genes that likely play a role in increased airway inflammation and mucin overproduction, and enhanced mucin gene expression appears to occur before eosinophil infiltration. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 chapter

Interleukin-13 induced mucous cell hyperplasia in airway epithelium.

In Cilia and mucus: from development to respiratory disease. (pp. 253–263).

By: L. Martin, M. Macchione, J. Bonner, B. Booth, N. Akley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Interleukin-13 induces proliferation of human airway epithelial cells in vitro via a mechanism mediated by transforming growth factor-alpha

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 25(6), 739–743.

MeSH headings : Bronchi / cytology; Bronchi / drug effects; Cell Division / drug effects; Cells, Cultured / cytology; Cells, Cultured / drug effects; Enzyme Inhibitors / pharmacology; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; ErbB Receptors / antagonists & inhibitors; ErbB Receptors / physiology; Humans; Interleukin-13 / pharmacology; Models, Biological; Quinazolines; Signal Transduction / drug effects; Signal Transduction / physiology; Transforming Growth Factor alpha / antagonists & inhibitors; Transforming Growth Factor alpha / immunology; Transforming Growth Factor alpha / metabolism; Tyrphostins / pharmacology
TL;DR: This study provides the first experimental evidence that IL-13 can initiate a proliferative response of human airway epithelium in the absence of inflammatory cells or other cell types. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 article

Interleukin-13, a mediator of subepithelial fibrosis, enhances growth factor production and proliferation in human airway epithelial cells

Booth, B., Bonner, J., Akley, N., Macchione, M., Adler, K., & Martin, L. D. (2001, July). CHEST, Vol. 120, pp. 15S–15S.

By: B. Booth n, J. Bonner*, N. Akley n, M. Macchione n, K. Adler n & L. Martin n

TL;DR: Injured airways with regions of regenerating/differentiating cells and regions of normal fully differentiated cells have been mimicked by examining the effects of IL-13 on normal human bronchial epithelial cells during mucociliary differentiation in air/liquid interface culture. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 article

MARCKS protein interaction with the cellular contractile machinery may regulate mucin secretion by human airway epithelium.

American Journal of Respiratory and Critical Care Medicine, Vol. 163, p. A225.

By: Y. Li, C. Pettersen, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

MARCKS protein is a key molecule regulating mucin secretion by human airway epithelial cells in vitro

JOURNAL OF BIOLOGICAL CHEMISTRY, 276(44), 40982–40990.

By: Y. Li*, L. Martin*, G. Spizz & K. Adler*

MeSH headings : Actins / metabolism; Amino Acid Sequence; Cyclic GMP-Dependent Protein Kinases / metabolism; Cytoplasm / metabolism; Down-Regulation; Enzyme Activation; Epithelial Cells / enzymology; Epithelial Cells / metabolism; Exocytosis; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Molecular Sequence Data; Mucins / metabolism; Myosins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Phosphorylation; Protein Kinase C / metabolism; Proteins / physiology; Trachea / cytology; Trachea / enzymology; Trachea / metabolism
TL;DR: Several novel intracellular targets for pharmacological intervention in disorders involving aberrant secretion of respiratory mucin are suggested and may relate to other lesions involving exocytosis of membrane-bound granules in various cells and tissues. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2001 chapter

MARCKS protein: a potential modulator of airway mucin secretion.

In Cilia and mucus: from development to respiratory disease. (pp. 179–193).

By: Y. Li, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Vanadium stimulates human bronchial epithelial cells to produce heparin-binding epidermal growth factor-like growth factor - A mitogen for lung fibroblasts

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 24(2), 123–131.

By: L. Zhang n, A. Rice n, K. Adler n, P. Sannes n, L. Martin n, W. Gladwell n, J. Koo n, T. Gray n, J. Bonner n

MeSH headings : Blotting, Northern; Blotting, Western; Bronchi / drug effects; Bronchi / metabolism; Cells, Cultured; DNA Primers / chemistry; Enzyme Inhibitors / pharmacology; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor / biosynthesis; Epidermal Growth Factor / genetics; Epithelial Cells / drug effects; Epithelial Cells / metabolism; ErbB Receptors / antagonists & inhibitors; Fibroblast Growth Factor 2 / metabolism; Fibroblasts / drug effects; Heparin-binding EGF-like Growth Factor; Humans; Immunoenzyme Techniques; Intercellular Signaling Peptides and Proteins; Lung / physiology; Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Protein Tyrosine Phosphatases / antagonists & inhibitors; RNA, Messenger / metabolism; Receptors, Platelet-Derived Growth Factor / antagonists & inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Vanadium / pharmacology; p38 Mitogen-Activated Protein Kinases
TL;DR: It is reported that conditioned medium from normal human bronchial epithelial cells (NHBECs) contains mitogenic activity for human lung fibroblasts that is blocked by the epidermal growth factor receptor (EGF-R) tyrosine kinase inhibitor AG1478 and by neutralizing antibodies raised against heparin-binding epidermis growth factor-like growth factor (HB-EGF). (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2000 chapter

Air-liquid interface culture systems for exposure of differentiated cells to oxidant stress.

In Models and methods in cell signaling and gene expression applications to oxidative stress research. (pp. 15–30).

By: F. He, K. Adler, N. Akley, B. Fischer, N. Jiang, T. Krunkosky, L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Differential generation of intracellular oxidants by TNF? and exogenous superoxide affords distinct expression of IL-6 in human airway epithelium in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 161, p. A152.

By: L. Martin, T. Krunkosky & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro - Signaling pathways controlling surface and gene expression

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 22(6), 685–692.

By: T. Krunkosky n, B. Fischer n, L. Martin n, N. Jones n, N. Akley n & K. Adler n

MeSH headings : Antibodies, Monoclonal; Bronchi / cytology; Cell Line; Epithelial Cells / enzymology; Epithelial Cells / immunology; Flow Cytometry; Gene Expression / immunology; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1 / genetics; Intercellular Adhesion Molecule-1 / immunology; L-Lactate Dehydrogenase / metabolism; NF-kappa B / genetics; NF-kappa B / metabolism; Promoter Regions, Genetic / physiology; RNA Processing, Post-Transcriptional / physiology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Respiratory Mucosa / cytology; Signal Transduction / immunology; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: The intracellular signaling pathway leading to enhanced expression appeared to involve activation of a phospholipase C that hydrolyzes phosphatidylcholine (PC-PLC) becaus... (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 article

Induction of heparin-binding epidermal growth factor (HB-EGF) mRNA in normal human bronchial epithelial cells by metal-induced oxidative stress.

American Journal of Respiratory and Critical Care Medicine, Vol. 161, p. A149.

By: J. Bonner, L. Zhang, P. Sannes, L. Martin, W. Gladwell, J. Koo, T. Gray, K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Interaction of TGF? and EGF receptor mediates IL-13 induced mucous cell hyperplasia in human airway epithelium in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 161, p. A779.

By: L. Martin, J. Bonner, M. Macchione, B. Booth, N. Akley & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2000 article

MARCKS protein: a key intracellular molecule controlling mucin secretion by human airway goblet cells.

American Journal of Respiratory and Critical Care Medicine, Vol. 161, p. A259.

By: Y. Li, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Mechanisms of human neutrophil elastase-induced mucin hypersecretion by human airway epithelial cells in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 161, p. A155.

By: F. He, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2000 article

Myristoylated alanine-rich C-kinase substrate protein: A major intracellular regulatory molecule controlling secretion of mucin by human airway goblet cells.

Chest, Vol. 117, pp. 266S–267S.

By: K. Adler, Y. Li & L. Martin

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

Residual oil fly ash induces cytotoxicity and mucin secretion by guinea pig tracheal epithelial cells via an oxidant-mediated mechanism

TOXICOLOGY AND APPLIED PHARMACOLOGY, 163(3), 221–230.

By: N. Jiang n, K. Dreher*, J. Dye*, Y. Li n, J. Richards*, L. Martin n, K. Adler n

author keywords: mucin; cytotoxicity; residual oil fly ash; oxidant
MeSH headings : Animals; Antioxidants / pharmacology; Carbon / toxicity; Cell Survival / drug effects; Cells, Cultured; Coal Ash; Dust / adverse effects; Epithelial Cells / drug effects; Gene Expression / drug effects; Guinea Pigs; Industrial Waste; Metals / toxicity; Mucins / biosynthesis; Mucins / genetics; Mucins / metabolism; Oxidants / pharmacology; Particulate Matter; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Trachea / cytology; Trachea / drug effects; Trachea / metabolism
TL;DR: ROFA enhances mucin secretion and generates toxicity in vitro to airway epithelium via a mechanism(s) involving generation of oxidant stress, perhaps related to depletion of cellular antioxidant capacity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 article

Response of human airway epithelium in vitro to inflammatory mediators - Dependence on the state of cellular differentiation

Martin, L. D., Norford, D., Voynow, J., & Adler, K. B. (2000, May). CHEST, Vol. 117, pp. 267S–267S.

By: L. Martin n, D. Norford*, J. Voynow* & K. Adler n

TL;DR: The data suggest that the response of the airway epithelium to inflammatory mediators may be markedly different in undifferentiated vs fully differentiated cells, and these responses may play a role in further exacerbation of airway inflammation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 article

Cloning and expression of guinea pig MUC2 and MUC5AC genes.

American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A852.

By: Y. Li, S. Greenfeder, L. Martin, M. Minnicozzi, J. Voynow & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1999 article

Myristoylated alanine-rich C kinase substrate (MARCKS) is produced by human airway epithelial cells and is phosphorylated by PKC and PKG.

American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A723.

By: Y. Li, F. He, L. Martin, T. Krunkosky, T. Lincoln, T. Cornwell, K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1999 article

TNF? effects on human airway epithelial cells in vitro: molecular mechanisms of enhanced mucin production/secretion and ICAM-I expression.

404nOtfound, Vol. 8, p. S55.

By: K. Adler, L. Martin, J. Voynow & T. Krunkosky

Source: NC State University Libraries
Added: August 6, 2018

1999 article

TNF?-induced ICAM-1 expression in airway epithelium: involvement of IkB?.

American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A184.

By: T. Krunkosky, L. Martin, Y. Li & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1999 article

Transcription factor activation during oxidant-regulated interleukin-6 expression in normal human bronchial epithelium in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A447.

By: L. Martin, T. Krunkosky & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Effects of inflammatory mediators and drugs on mucus secretion and mucociliary function.

404nOtfound, 149, 245–248.

By: K. Adler, B. Fischer, L. Martin & J. Voynow

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Intracellular reactive oxygen and nitrogen species as signaling molecules in airway epithelium.

Environmental Health Perspectives, 106, 1197–1203.

By: L. Martin, T. Krunkosky, J. Voynow & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1998 chapter

Oxidant-regulated gene expression in inflammatory lung disease.

In Acute respiratory distress syndrome: cellular and molecular mechanisms and clinical management. (pp. 187–195).

By: L. Martin n, T. Krunkosky n, J. Voynow* & K. Adler n

TL;DR: Acute respiratory distress syndrome is characterized by severe hypoxemia, diffuse pulmonary infiltrates and poor lung compliance in the absence of left heart failure. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1998 article

The role of reactive oxygen and nitrogen species in airway epithelial gene expression

Martin, L. D., Krunkosky, T. M., Voynow, J. A., & Adler, K. B. (1998, October). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 106, pp. 1197–1203.

By: L. Martin n, T. Krunkosky n, J. Voynow n & K. Adler n

author keywords: reactive oxygen/nitrogen species; signal transduction; intracellular oxidants; ICAM-1; IL-6; TNF-alpha
Source: Web Of Science
Added: August 6, 2018

1997 review

Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators

[Review of ]. EUROPEAN RESPIRATORY JOURNAL, 10(9), 2139–2146.

By: L. Martin n, L. Rochelle n, B. Fischer n, T. Krunkosky n & K. Adler n

author keywords: airway; cytokines; eicosanoids; epithelium; inflammation; reactive oxygen/nitrogen species
MeSH headings : Animals; Cytokines / metabolism; Epithelium / metabolism; Humans; Inflammation / metabolism; Inflammation / physiopathology; Inflammation Mediators / metabolism; Lipid Metabolism; Reactive Oxygen Species / metabolism; Respiratory System / metabolism; Respiratory System / pathology
TL;DR: The production of cytokines by the airway epithelium is shown to play a role in causing inflammation associated with respiratory diseases, and molecular mechanisms governing the expression of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleUKin-8 ( IL-8) are discussed. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1997 article

Mechanisms of TNF?-induced ICAM-1 expression in airway epithelium.

American Journal of Respiratory and Critical Care Medicine, Vol. 155, p. A207.

By: T. Krunkosky, L. Martin, B. Fischer & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1997 article

TNF? and oxidant-induced expression of Interleukin-6 in normal human bronchial epithelium in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 155, p. A206.

By: L. Martin, T. Krunkosky, L. Rochelle & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1997 article

The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates

Martin, L. D., Krunkosky, T. M., Dye, J. A., Fischer, B. M., Jiang, N. F., Rochelle, L. G., … Adler, K. B. (1997, September). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 105, pp. 1301–1307.

By: L. Martin n, T. Krunkosky n, J. Dye n, B. Fischer n, N. Jiang n, L. Rochelle n, N. Akley n, K. Dreher n, K. Adler n

author keywords: reactive oxygen/nitrogen species; signal transduction; airway inflammation; mucin hypersecretion; ICAM-1; TNF-alpha
Source: Web Of Science
Added: August 6, 2018

1996 article

Role or reactive oxygen and nitrogen species in the response of airway epithelium to particulates.

Proceedings of the 6th International Meeting of the Toxicology of Natural and Man-Made Fibrous and Non-Fibrous Particles., Vol. 6, p. 139.

By: K. Adler, T. Krunkosky, B. Fischer, L. Rochelle, L. Martin, K. Dreher, N. Jiang, J. Dye

Source: NC State University Libraries
Added: August 6, 2018

1996 article

Tumor necrosis factor alpha (TNF?) provokes expression of intercellular adhesion molecule-1 (ICAM-1) on human bronchial epithelial cells in primary culture.

American Journal of Respiratory and Critical Care Medicine, Vol. 153, p. A27.

By: T. Krunkosky, B. Fischer, L. Martin & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

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