@article{large_mathies_2014, title={Caenorhabditis elegans SWI/SNF subunits control sequential developmental stages in the somatic gonad}, volume={4}, number={3}, journal={G3-Genes Genomes Genetics}, author={Large, E. E. and Mathies, L. D.}, year={2014}, pages={471–483} }
 @article{stowe_tucker_thompson_piper_richards_rogers_mathies_melander_cavanagh_2012, title={Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems}, volume={35}, ISSN={["1525-6014"]}, DOI={10.3109/01480545.2011.614620}, abstractNote={Biofilm formation is a ubiquitous bacterial defense mechanism and has been shown to be a primary element in the antibiotic resistance of many human diseases, especially in the case of nosocomial infections. Recently, we have developed several compound libraries that are extremely effective at both dispersing preexisting biofilms and also inhibiting their initial formation. In addition to their antibiofilm properties, some of these molecules are able to resensitize resistant bacterial strains to previously ineffective antibiotics and are being assessed as adjuvants. In this study, we evaluated the toxic effects of three of our most effective 2-aminoimidazole compounds (dihydrosventrin, RA, and SPAR) using a rapid pipeline that combines a series of assays. A methylthiazolyldiphenyl-tetrazolium assay, using the HaCaT keratinocyte cell line was used to determine epidermal irritants and was combined with Caenorhabditis elegans fecundity assays that demonstrated the effects of environmental exposure to various concentrations of these molecules. In each case, the assays showed that the compounds did not exhibit toxicity until they reached well above their current biofilm dispersion/inhibition concentrations. The most effective antibiofilm compound also had significant effects when used in conjunction with several standard antibiotics against resistant bacteria. Consequently, it was further investigated using the C. elegans assay in combination with different antibiotics and was found to maintain the same low level of toxicity as when acting alone, bolstering its candidacy for further testing as an adjuvant.}, number={3}, journal={DRUG AND CHEMICAL TOXICOLOGY}, author={Stowe, Sean D. and Tucker, Ashley T. and Thompson, Richele and Piper, Amanda and Richards, Justin J. and Rogers, Steven A. and Mathies, Laura D. and Melander, Christian and Cavanagh, John}, year={2012}, month={Jul}, pages={310–315} }
 @article{large_mathies_2010, title={hunchback and Ikaros-like zinc finger genes control reproductive system development in Caenorhabditis elegans}, volume={339}, number={1}, journal={Developmental Biology}, author={Large, E. E. and Mathies, L. D.}, year={2010}, pages={51–64} }
 @article{richards_reyes_stowe_tucker_ballard_mathies_cavanagh_melander_2009, title={Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity}, volume={52}, ISSN={["1520-4804"]}, DOI={10.1021/jm900378s}, abstractNote={The synthesis and antibiofilm activities of sulfonamide, urea, and thiourea oroidin analogues are described. The most active derivative was able to selectively inhibit P. aeruginosa biofilm development and is also shown to be nontoxic upward of 1 mM to the development of C. elegans in comparison to other similar isosteric analogues and the natural product oroidin.}, number={15}, journal={JOURNAL OF MEDICINAL CHEMISTRY}, author={Richards, Justin J. and Reyes, Samuel and Stowe, Sean D. and Tucker, Ashley T. and Ballard, T. Eric and Mathies, Laura D. and Cavanagh, John and Melander, Christian}, year={2009}, month={Aug}, pages={4582–4585} }
 @article{kelleher_carvalho_doty_layton_cheng_mathies_pilgrims_haag_2008, title={Comparative genetics of sex determination: Masculinizing mutations in Caenorhabditis briggsae}, volume={178}, ISSN={["0016-6731"]}, DOI={10.1534/genetics.107.073668}, abstractNote={Abstract}, number={3}, journal={GENETICS}, author={Kelleher, Danielle F. and Carvalho, Carlos Egydio and Doty, Alana V. and Layton, Marnie and Cheng, Andy T. and Mathies, Laura D. and Pilgrims, Dave and Haag, Eric S.}, year={2008}, month={Mar}, pages={1415–1429} }
 @article{large_mathies_2007, title={Chromatin regulation and sex determination in Caenorhabditis elegans}, volume={23}, ISSN={["1362-4555"]}, DOI={10.1016/j.tig.2007.04.002}, abstractNote={Glioma-associated oncogene (GLI) transcription factors function downstream of the hedgehog signal transduction pathway to regulate the development of many animals. Although the nematode Caenorhabditis elegans lacks a hedgehog pathway, it does have a GLI protein that represses male development in favor of hermaphrodite development. As we discuss here, recent findings implicate two conserved transcription-repressor complexes in the repression of male-specific genes. This research indicates a possible conserved role for these complexes in either GLI-directed gene repression or sex determination.}, number={7}, journal={TRENDS IN GENETICS}, author={Large, Edward E. and Mathies, Laura D.}, year={2007}, month={Jul}, pages={314–317} }
 @article{welchman_mathies_ahringer_2007, title={Similar requirements for CDC-42 and the PAR-3/PAR-6/PKC-3 complex in diverse cell types}, volume={305}, ISSN={["1095-564X"]}, DOI={10.1016/j.ydbio.2007.02.022}, abstractNote={During animal development, a complex of Par3, Par6 and atypical protein kinase C (aPKC) plays a central role in cell polarisation. The small G protein Cdc42 also functions in cell polarity and has been shown in some cases to act by regulating the Par3 complex. However, it is not yet known whether Cdc42 and the Par3 complex widely function together in development or whether they have independent functions. For example, many studies have implicated Cdc42 in cell migrations, but the Par3 complex has only been little studied, with conflicting results. Here we examine the requirements for CDC-42 and the PAR-3/PAR-6/PKC-3 complex in a range of different developmental events. We found similar requirements in all tissues examined, including polarised growth of vulval precursors and seam cells, migrations of neuroblasts and axons, and the development of the somatic gonad. We also propose a novel role for primordial germ cells in mediating coalescence of the Caenorhabditis elegans gonad. These results indicate that CDC-42 and the PAR-3/PAR-6/aPKC complex function together in diverse cell types.}, number={1}, journal={DEVELOPMENTAL BIOLOGY}, author={Welchman, David P. and Mathies, Laura D. and Ahringer, Julie}, year={2007}, month={May}, pages={347–357} }
 @article{mathies_schvarzstein_morphy_blelloch_spence_kimble_2004, title={TRA-1/GLI controls development of somatic gonadal precursors in C-elegans}, volume={131}, number={17}, journal={Development (Cambridge, England)}, author={Mathies, L. D. and Schvarzstein, M. and Morphy, K. M. and Blelloch, R. and Spence, A. M. and Kimble, J.}, year={2004}, pages={4333–4343} }