Laura Elizabeth Griffin

Works (11)

Updated: August 24th, 2023 10:30

2023 journal article

Bioavailable Microbial Metabolites of Flavanols Demonstrate Highly Individualized Bioactivity on In Vitro & beta;-Cell Functions Critical for Metabolic Health

Bioavailable Microbial Metabolites of Flavanols Demonstrate Highly Individualized Bioactivity on In Vitro & beta;-Cell Functions Critical for Metabolic Health. METABOLITES, 13(7).

By: E. Krueger *, L. Griffin n, J. Beales*, T. Lloyd *, N. Brown *, W. Elison *, C. Kay n , A. Neilson n , J. Tessem *

author keywords: gut microbiome; phytochemicals; flavanol metabolites; glucose sensitivity; responder analysis; personalized nutrition
TL;DR: It is concluded that metabolite bioactivity on GSIS capacity is less related to flavanol supplementation or antibiotic treatment and may be more associated with the unique microbiome or metabolome of each animal, suggesting flavanol metabolite activities are individualized and point to the need for personalized nutrition practices. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 14, 2023

2021 journal article

Fasting and postprandial trimethylamine <i>N ‐oxide in sedentary and endurance‐trained males following a short‐term high‐fat diet

Physiological Reports, 9(16).

By: C. Steele *, M. Baugh *, L. Griffin n, A. Neilson n , B. Davy *, M. Hulver *, K. Davy*

author keywords: endurance-trained; high-fat diet; sedentary; trimethylamine N-oxide
MeSH headings : Adolescent; Adult; Cardiometabolic Risk Factors; Diet, High-Fat / adverse effects; Dietary Fats / metabolism; Endurance Training; Fasting / metabolism; Humans; Male; Methylamines / blood; Postprandial Period; Sedentary Behavior
TL;DR: Plasma TMAO and TMA‐moiety concentrations were measured using isocratic ultraperformance liquid chromatography‐tandem mass spectrometry and VO2max was significantly higher in the endurance‐trained compared with sedentary males, and future studies are needed to identify the effects of endurance training on T MAO production. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: September 7, 2021

2021 journal article

Microbial Metabolites of Flavanols in Urine are Associated with Enhanced Anti-Proliferative Activity in Bladder Cancer Cells In Vitro

Nutrition and Cancer, 74(1), 194–210.

By: L. Griffin n, S. Kohrt *, A. Rathore n, C. Kay n , M. Grabowska * & A. Neilson n 

MeSH headings : Animals; Chromatography, Liquid; Gastrointestinal Microbiome; Polyphenols / analysis; Rats; Tandem Mass Spectrometry; Urinary Bladder Neoplasms / drug therapy
TL;DR: It is suggested that microbial metabolites may be the primary compounds responsible for chemoprevention in uroepithelial cell following flavanol consumption, highlighting the potential for exploiting knowledge about individual genetics, microbiome profiles, flavonoid metabolism profiles, tumor characteristics, etc. to design personalized dietary interventions for cancer prevention and/or adjuvant therapy to reduce bladder cancer incidence and improve outcomes. (via Semantic Scholar)
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Added: February 10, 2021

2020 journal article

Diet-induced obesity in genetically diverse collaborative cross mouse founder strains reveals diverse phenotype response and amelioration by quercetin treatment in 129S1/SvImJ, PWK/EiJ, CAST/PhJ, and WSB/EiJ mice

The Journal of Nutritional Biochemistry, 87, 108521.

By: L. Griffin n, L. Essenmacher *, K. Racine n, L. Iglesias-Carres  n, J. Tessem *, S. Smith *, A. Neilson n 

author keywords: Natural products; Genetic diversity; Diabetes; Flavonoids; Personalized nutrition; Interindividual variation
MeSH headings : Animals; Anti-Obesity Agents / therapeutic use; Collaborative Cross Mice / genetics; Collaborative Cross Mice / physiology; Diet, High-Fat / adverse effects; Disease Models, Animal; Female; Genetic Variation; Male; Obesity / drug therapy; Obesity / etiology; Obesity / genetics; Quercetin / therapeutic use; Sex Factors
TL;DR: How diverse mouse strains respond to diet-induced obesity when fed a representative flavonoid is explored to justify use of genetically diverse Collaborative Cross and Diversity Outbred models which are emerging as invaluable tools in the field of personalized nutrition. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: January 11, 2021

2020 journal article

Modulating Phenolic Bioaccessibility and Glycemic Response of Starch-Based Foods in Wistar Rats by Physical Complexation between Starch and Phenolic Acid

Journal of Agricultural and Food Chemistry, 68(46), 13257–13266.

By: M. Li n, L. Griffin n, S. Corbin n, A. Neilson n  & M. Ferruzzi n

author keywords: LC-MS; in vitro bioaccessibility; cellular uptake efficiency; postprandial glycemic response; Caco-2 human intestinal cells; starch-phenolic complexes
MeSH headings : Animals; Blood Glucose / metabolism; Caco-2 Cells; Glycemic Index; Humans; Hydroxybenzoates / metabolism; Intestines; Male; Phenols / metabolism; Rats; Rats, Wistar; Solanum tuberosum / metabolism; Starch / analysis; Starch / metabolism; Zea mays / metabolism
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Added: January 4, 2021

2020 article

Supplemental treatment options for diabetes: how flavanol metabolites improve beta-cell function

Lloyd, T., Griffin, L., Krueger, E., Beales, J., Barlow, A., Sheets, J., … Tessem, J. (2020, April). FASEB JOURNAL, Vol. 34.

By: T. Lloyd *, L. Griffin n, E. Krueger *, J. Beales*, A. Barlow*, J. Sheets*, I. Ekpo*, M. Ross* ...

TL;DR: Data is presented regarding the in vitro effects of these absorbed gut bacteria derived flavanoids on INS‐1 832/13 β‐cell insulin secretion and proliferation and further light is shed on the potential ability of flavanoid and their gut bacteriaderived metabolites to enhance functional β‐ cell mass. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020

2019 journal article

A Mediterranean diet does not alter plasma trimethylamine<i>N</i>-oxide concentrations in healthy adults at risk for colon cancer

Food & Function, 10(4), 2138–2147.

By: L. Griffin*, Z. Djuric *, C. Angiletta*, C. Mitchell *, M. Baugh *, K. Davy*, A. Neilson* 

MeSH headings : Adult; Aged; Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; Bacteria / metabolism; Betaine / blood; Choline / blood; Colonic Neoplasms / blood; Colonic Neoplasms / diet therapy; Colonic Neoplasms / metabolism; Colonic Neoplasms / microbiology; Diet, Mediterranean; Fasting; Female; Gastrointestinal Microbiome; Humans; Male; Methylamines / blood; Middle Aged
TL;DR: It is suggested that broad dietary pattern intervention over six months may not be sufficient for reducing TMAO concentrations in an otherwise healthy population, and disruption of the conversion of dietary TMA to T MAO should be the focus of future studies. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: April 20, 2020

2019 journal article

Comparison of Common Analytical Methods for the Quantification of Total Polyphenols and Flavanols in Fruit Juices and Ciders

Journal of Food Science, 84(8), 2147–2158.

By: S. Ma *, C. Kim*, A. Neilson n , L. Griffin n, G. Peck *, S. O'Keefe*, A. Stewart* 

author keywords: BSA precipitation; DMAC; flavanols; Folin-Ciocalteu; Lowenthal permanganate titration
MeSH headings : Flavanones / analysis; Food Analysis / methods; Fruit / chemistry; Fruit and Vegetable Juices / analysis; Malus / chemistry; Polyphenols / analysis
TL;DR: Results obtained can help manufacturers of fruit‐based products choose the most appropriate analytical method for polyphenol quantification as part of a quality assurance program or to convey information on dietarypolyphenol content to consumers. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 5, 2019

2019 journal article

Flavanol Polymerization Is a Superior Predictor of α-Glucosidase Inhibitory Activity Compared to Flavanol or Total Polyphenol Concentrations in Cocoas Prepared by Variations in Controlled Fermentation and Roasting of the Same Raw Cocoa Beans

Antioxidants, 8(12), 635.

By: K. Racine*, B. Wiersema *, L. Griffin n, L. Essenmacher *, A. Lee *, H. Hopfer *, J. Lambert *, A. Stewart *, A. Neilson n 

author keywords: flavan-3-ol; procyanidin; alpha-glucosidase; melanoidin; Maillard reaction
TL;DR: It is demonstrated that cocoa powders are potent inhibitors of α-glucosidase, and non-traditional compositional markers may be better predictors of enzyme inhibitory activity than cocoa native flavanols. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: January 27, 2020

2019 journal article

Flavanol supplementation protects against obesity-associated increases in systemic interleukin-6 levels without inhibiting body mass gain in mice fed a high-fat diet

Nutrition Research, 66, 32–47.

By: L. Griffin*, D. Fausnacht *, J. Tuzo*, A. Addington *, K. Racine*, H. Zhang*, M. Hughes *, K. England* ...

author keywords: Mean degree of polymerization (mDP); Flavanols; Procyanidins (PCs); Glucose intolerance; Cytokines
MeSH headings : Adipose Tissue / chemistry; Animals; Body Composition / drug effects; Diet, High-Fat / adverse effects; Dietary Supplements; Eating / drug effects; Flavonols / administration & dosage; Glucose Intolerance / prevention & control; Grape Seed Extract / chemistry; Inflammation / prevention & control; Insulin Resistance; Interleukin-6 / analysis; Male; Mice; Mice, Inbred C57BL; Obesity / physiopathology; Pinus / chemistry; Plant Bark / chemistry; Weight Gain / drug effects
TL;DR: Overall, low-dose flavanol extract supplementation, regardless of mean degrees of polymerization, blunted cytokine production despite increased weight gain, suggesting flavanols may be used as complementary interventions to ameliorate increased inflammatory tone in the contexts of obesity and diabetes. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: July 22, 2019

2019 journal article

Preference for and sensitivity to flavanol mean degree of polymerization in model wines is correlated with body composition

Appetite, 144, 104442.

By: L. Griffin n, C. Diako *, L. Miller *, A. Neilson n , C. Ross * & A. Stewart* 

author keywords: Astringency; Preference; BMI; Body fat percentage; PROP
MeSH headings : Adipose Tissue; Adult; Body Composition / physiology; Body Mass Index; Body Weight / physiology; Female; Food Preferences / drug effects; Food Preferences / physiology; Humans; Male; Middle Aged; Polymerization; Polyphenols / administration & dosage; Propylthiouracil / administration & dosage; Taste / drug effects; Taste / physiology; Taste Buds / drug effects; Taste Threshold / drug effects; Wine / analysis; Young Adult
TL;DR: The data suggest that weight status in adults is a greater predictor of liking of flavanol-rich foods than bitterness sensitivity (as determined by PROP classification), and that reduced perception of bitterness and astringency associated with weight gain may impact selection and preference for these foods. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: December 9, 2019

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