Works (6)
Updated: July 5th, 2023 15:40
2019 journal article
Investigation of multiphasic 3D-bioplotted scaffolds for site-specific chondrogenic and osteogenic differentiation of human adipose-derived stem cells for osteochondral tissue engineering applications
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 108(5), 2017–2030.
author keywords: 3D-printing; chondrogenic differentiation; human adipose derived stem cells; osteochondral; osteogenic differentiation
MeSH headings : Adipose Tissue / metabolism; Biocompatible Materials / chemistry; Bone and Bones; Calcium Phosphates / chemistry; Calcium Phosphates / metabolism; Cartilage, Articular / metabolism; Cell Differentiation; Cells, Cultured; Chondrogenesis / physiology; Collagen Type I / genetics; Collagen Type I / metabolism; Extracellular Matrix / chemistry; Extracellular Matrix / metabolism; Humans; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Osteogenesis / physiology; Polyesters / chemistry; Polyesters / metabolism; Printing, Three-Dimensional; Tissue Engineering; Tissue Scaffolds / chemistry
TL;DR:
A scaffold that would induce site‐specific osteogenic and chondrogenic differentiation of human adipose‐derived stem cells (hASC) to generate a full osteochondral implant is created and holds great promise as cartilage morbidity is minimized since autologous cartilage harvest is not required.
(via Semantic Scholar)
open access via onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 6, 2020
2017 journal article
Comparison of simulated microgravity and hydrostatic pressure for chondrogenesis of hASC
Aerospace Medicine and Human Performance, 88(4), 377–384.
Source: NC State University Libraries
Added: August 6, 2018
2017 journal article
Effects of 3D-bioplotted polycaprolactone scaffold geometry on human adipose-derived stem cell viability and proliferation
RAPID PROTOTYPING JOURNAL, 23(3), 534–542.
Contributors: S. Mehendale n, n, M. Taylor n, E. Loboa n & R. Shirwaiker n
author keywords: 3D-Bioplotting; Human adipose-derived stem cells; Polycaprolactone; Tissue engineering scaffolds
TL;DR:
The design with the lowest porosity had the highest compression modulus after 14 days of culture, but resulted in the lowest hASC viability, which provided the basis for future studies which will use this optimal scaffold design to develop constructs for hASC-based osteochondral tissue engineering applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2017 journal article
Fabrication and Evaluation of Electrospun, 3D-Bioplotted, and Combination of Electrospun/3D-Bioplotted Scaffolds for Tissue Engineering Applications
BIOMED RESEARCH INTERNATIONAL, 2017.
Contributors: n, P. Huebner n, S. Cai n, M. Mohiti-Asli n, M. Taylor n, J. Spang *, R. Shirwaiker n , E. Loboa *
MeSH headings : Animals; Cells, Cultured; Extracellular Matrix / chemistry; Humans; Nanofibers / chemistry; Nanofibers / therapeutic use; Polyesters / chemistry; Polyesters / therapeutic use; Porosity; Printing, Three-Dimensional; Swine; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
The approach combining these two commonly used scaffold fabrication technologies allows for the creation of a scaffold with more close resemblance to heterogeneous tissue architecture, holding great potential for tissue engineering and regenerative medicine applications of osteochondral tissue and other heterogeneous tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Continuous-wave stimulated emission depletion microscope for imaging actin cytoskeleton in fixed and live cells
Sensors (Basel, Switzerland), 15(9), 24178–24190.
Source: NC State University Libraries
Added: August 6, 2018
2015 journal article
Extracellular Calcium Modulates Chondrogenic and Osteogenic Differentiation of Human Adipose-Derived Stem Cells: A Novel Approach for Osteochondral Tissue Engineering Using a Single Stem Cell Source
TISSUE ENGINEERING PART A, 21(17-18), 2323–2333.
MeSH headings : Adipose Tissue / cytology; Adult; Calcification, Physiologic / drug effects; Calcium / pharmacology; Calcium Phosphates / pharmacology; Cell Differentiation / drug effects; Cells, Cultured; Chondrogenesis / drug effects; Extracellular Space / chemistry; Gene Expression Regulation / drug effects; Glycosaminoglycans / metabolism; Humans; Immunohistochemistry; Lactic Acid / pharmacology; Osteogenesis / drug effects; Polyesters; Polymers / pharmacology; Stem Cells / cytology; Stem Cells / drug effects; Stem Cells / ultrastructure; Tissue Engineering / methods; Tissue Scaffolds; Young Adult
TL;DR:
This is the first study to report the effects of elevated calcium on chondrogenic differentiation of hASC, and to develop osteochondral nanofibrous scaffolds using a single cell source and controlled calcium release to induce site-specific differentiation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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