Works (3)

Updated: July 5th, 2023 15:40

2016 journal article

The effect of high dose oral manganese exposure on copper, iron and zinc levels in rats

BIOMETALS, 29(3), 417–422.

By: C. Mercadante*, C. Herrera*, M. Pettiglio*, M. Foster n, L. Johnson n, D. Dorman n, T. Bartnikas*

author keywords: Manganese; Copper; Iron; Zinc; Exposure
MeSH headings : Administration, Oral; Animals; Copper / metabolism; Diet; Homeostasis / drug effects; Iron / metabolism; Male; Manganese / administration & dosage; Manganese / analysis; Manganese / toxicity; Rats; Rats, Inbred F344; Zinc / metabolism
TL;DR: While manganese exposure affected levels of all metals, particularly in the frontal cortex and liver, copper levels were most prominently affected and suggests an under-appreciated effect of manganae exposure on copper homeostasis which may contribute to the understanding of the pathophysiology of mangansese toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Pharmacokinetic Evaluation of the Equivalency of Gavage, Dietary, and Drinking Water Exposure to Manganese in F344 Rats


By: M. Foster n, T. Bartnikas n, L. Johnson n, C. Herrera n, M. Pettiglio n, A. Keene n, M. Taylor n, D. Dorman n

author keywords: manganese; pharmacokinetics; oral exposure; dose rate
MeSH headings : Administration, Oral; Animals; Body Burden; Chlorides / administration & dosage; Chlorides / pharmacokinetics; Chlorides / toxicity; Diet; Food Contamination; Male; Manganese Compounds / administration & dosage; Manganese Compounds / pharmacokinetics; Manganese Poisoning / etiology; Rats, Inbred F344; Risk Assessment; Tissue Distribution; Water Pollutants, Chemical / administration & dosage; Water Pollutants, Chemical / pharmacokinetics; Water Pollutants, Chemical / toxicity
TL;DR: Increased femur, striatum, cerebellum, frontal cortex, and olfactory bulb manganese concentrations were also seen following gavage suggesting that dose rate is an important factor in the pharmacokinetics of oral mangansese. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Interactive effects of pesticide mixtures, predators, and environmental regimes on the toxicity of two pesticides to red-eyed tree frog larvae

Environmental Toxicology and Chemistry, 32(10), 2379–2386.

By: L. Johnson, B. Welch & S. Whitfield

Source: NC State University Libraries
Added: August 6, 2018

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