Laura Kimberly Gardner

Works (3)

Updated: August 16th, 2023 21:15

2014 journal article

Intracellular Light-Activation of Riboswitch Activity

ChemBioChem, 15(9), 1346–1351.

By: S. Walsh n, L. Gardner n, A. Deiters n & G. Williams n 

author keywords: chemical biology; photocontrol; riboswitches; RNA; synthetic biology
MeSH headings : Cell Membrane Permeability; Gene Expression Regulation / drug effects; Gene Expression Regulation / radiation effects; Intracellular Space / drug effects; Intracellular Space / genetics; Intracellular Space / radiation effects; Ligands; Molecular Structure; Riboswitch / drug effects; Riboswitch / genetics; Riboswitch / radiation effects; Structure-Activity Relationship; Theophylline / chemistry; Theophylline / pharmacology; Ultraviolet Rays
topics (OpenAlex): Photochromic and Fluorescence Chemistry; Antimicrobial Peptides and Activities; RNA and protein synthesis mechanisms
TL;DR: By combining a riboswitch with a cell‐permeable photocaged small‐molecule ligand, an optochemical gene control element was constructed that enabled spatial and temporal control of gene expression in bacterial cells. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 review

Light-controlled synthetic gene circuits

[Review of ]. CURRENT OPINION IN CHEMICAL BIOLOGY, 16(3-4), 292–299.

By: L. Gardner n & A. Deiters n

MeSH headings : Animals; Cell Line; Gene Regulatory Networks / drug effects; Gene Regulatory Networks / radiation effects; Genetic Engineering / methods; Humans; Light; Photochemical Processes
topics (OpenAlex): bioluminescence and chemiluminescence research; Photoreceptor and optogenetics research; Advanced biosensing and bioanalysis techniques
TL;DR: Recent advancements in the area of light-controlled synthetic networks are described, which allows for the regulation of intermediate steps of complex dynamic pathways in mammalian cells such as those involved in kinase networks. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 journal article

Photochemical control of bacterial signal processing using a light-activated erythromycin

MOLECULAR BIOSYSTEMS, 7(9), 2554–2557.

By: L. Gardner n, Y. Zou n, A. Mara n, T. Cropp * & A. Deiters n

MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / genetics; Erythromycin / pharmacology; Escherichia coli / genetics; Escherichia coli / metabolism; Escherichia coli / radiation effects; Exoribonucleases / genetics; Exoribonucleases / metabolism; Light; Photochemistry / methods
topics (OpenAlex): Photoreceptor and optogenetics research; bioluminescence and chemiluminescence research; Photochromic and Fluorescence Chemistry
TL;DR: This work engineered the MphR(A)/promoter system to enable photochemical activation of gene expression in E. coli, and applied this photochemical gene switch to the construction of a light-triggered logic gate, aLight-controlled band-pass filter, as well as spatial and temporal control of geneexpression. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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